In the rat, the magnitude of the hypoglycaemic response to a dose of tolbutamide (50 mg/kg per os) which does not depress blood glucose levels to the point where adrenal compensatory mechanisms are stimulated is unaffected by adrenalectomy. On the other hand, when a dose is given which induces a greater hypoglycaemia (100 mg/kg per os) a very significant difference between adrenalectomized and sham-operated animals is observed, the adrenalectomized rats displaying a far greater sensitivity to the hypoglycaemic action of this compound. In intact rats, the hypoglycaemia induced by tolbutamide (100 mg/kg per os) is lessened by pretreatment of the animals with Dibenzyline (4 mg/kg) but enhanced by the prior injection of dihydroergotamine (2 mg/kg). Larger doses of dihydroergotamine alone cause a reduction in glucose levels of tail blood which is greater than that found in carotid blood samples withdrawn at the same times.
{"title":"THE EFFECT OF ADRENALECTOMY, DIHYDROERGOTAMINE, AND DIBENZYLINE ON THE SENSITIVITY OF RATS TO TOLBUTAMIDE.","authors":"R. Hawkins, R. E. Haist","doi":"10.1139/O63-246","DOIUrl":"https://doi.org/10.1139/O63-246","url":null,"abstract":"In the rat, the magnitude of the hypoglycaemic response to a dose of tolbutamide (50 mg/kg per os) which does not depress blood glucose levels to the point where adrenal compensatory mechanisms are stimulated is unaffected by adrenalectomy. On the other hand, when a dose is given which induces a greater hypoglycaemia (100 mg/kg per os) a very significant difference between adrenalectomized and sham-operated animals is observed, the adrenalectomized rats displaying a far greater sensitivity to the hypoglycaemic action of this compound. In intact rats, the hypoglycaemia induced by tolbutamide (100 mg/kg per os) is lessened by pretreatment of the animals with Dibenzyline (4 mg/kg) but enhanced by the prior injection of dihydroergotamine (2 mg/kg). Larger doses of dihydroergotamine alone cause a reduction in glucose levels of tail blood which is greater than that found in carotid blood samples withdrawn at the same times.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"9 1","pages":"2189-95"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83389688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"URINARY AND FECAL CONVERSION PRODUCTS OF 16-OXOESTRADIOL-17-BETA-16-C14 IN THE DOMESTIC FOWL.","authors":"L AINSWORTH, R H COMMON","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2045-55"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23667094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cellular elements of blood obtained from birds with virus-induced erythroblastosis rapidly incorporated radioactivity when incubated in vitro with Fe59Cl3. This effect was not seen until primitive red cells entered the circulating blood. Little of the iron that was incorporated reached heme. Instead most of it was retained by a heat-resistant component which was precipitable with 35% ammonium sulphate and had properties suggestive of a ferritin-like substance. Plasma from leukemic blood had a slight promoting effect on incorporation of Fe59 into normal blood cells in vitro when compared with normal plasma.Blood cells from birds in which the bone marrow was rendered hyperactive with phenylhydrazine also incorporated Fe59 in vitro, a large proportion of this reaching heme. Incorporation into the heme fraction was also observed in blood cells from erythroblastosis-infected birds treated with phenylhydrazine, indicating that heme synthesis was not completely blocked in these birds.
{"title":"IN VITRO UPTAKE OF FE59 BY BLOOD CELLS FROM NORMAL BIRDS AND BIRDS WITH ERYTHROBLASTOSIS.","authors":"R. Bather, S. Dzuibalo, L. E. Darcelcq","doi":"10.1139/O63-235","DOIUrl":"https://doi.org/10.1139/O63-235","url":null,"abstract":"The cellular elements of blood obtained from birds with virus-induced erythroblastosis rapidly incorporated radioactivity when incubated in vitro with Fe59Cl3. This effect was not seen until primitive red cells entered the circulating blood. Little of the iron that was incorporated reached heme. Instead most of it was retained by a heat-resistant component which was precipitable with 35% ammonium sulphate and had properties suggestive of a ferritin-like substance. Plasma from leukemic blood had a slight promoting effect on incorporation of Fe59 into normal blood cells in vitro when compared with normal plasma.Blood cells from birds in which the bone marrow was rendered hyperactive with phenylhydrazine also incorporated Fe59 in vitro, a large proportion of this reaching heme. Incorporation into the heme fraction was also observed in blood cells from erythroblastosis-infected birds treated with phenylhydrazine, indicating that heme synthesis was not completely blocked in these birds.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"142 1","pages":"2057-64"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76528122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alcohol injected intraperitoneally in a dose of 0.4 g/kg causes a small but significant elevation in the metabolic rate of anaesthetized rats. This effect appears to be masked in unanaesthetized rats, particularly with larger doses, presumably because of the sedative effect of the ethanol. Pretreatment with iproniazid (100 ing/kg) or phenoxybenzamine (10 mg/kg) failed to enhance or to block, respectively, the initial elevation in oxygen consumption induced by ethanol. These results suggest that the initial increase in oxygen consumption is brought about by some mechanism other than the release of adrenaline or of noradrenaline. Calculations suggest that this increase could be accounted for by preferential oxidation of ethanol in place of its caloric equivalent as glucose.
{"title":"THE EFFECT OF ETHANOL ON THE METABOLIC RATE OF RATS.","authors":"H. Kalant, R. Hawkins, G. S. Watkin","doi":"10.1139/O63-247","DOIUrl":"https://doi.org/10.1139/O63-247","url":null,"abstract":"Alcohol injected intraperitoneally in a dose of 0.4 g/kg causes a small but significant elevation in the metabolic rate of anaesthetized rats. This effect appears to be masked in unanaesthetized rats, particularly with larger doses, presumably because of the sedative effect of the ethanol. Pretreatment with iproniazid (100 ing/kg) or phenoxybenzamine (10 mg/kg) failed to enhance or to block, respectively, the initial elevation in oxygen consumption induced by ethanol. These results suggest that the initial increase in oxygen consumption is brought about by some mechanism other than the release of adrenaline or of noradrenaline. Calculations suggest that this increase could be accounted for by preferential oxidation of ethanol in place of its caloric equivalent as glucose.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"4 1","pages":"2197-203"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84321354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PARTIAL PURIFICATION AND PROPERTIES OF PROLYL-RNA SYNTHETASE OF RAT LIVER.","authors":"M J FRASER, D B KLASS","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2123-40"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23666649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE METABOLISM OF MUCOPOLYSACCHARIDES. I. ADRENAL STEROIDS AND THE SYNTHESIS OF GLUCOSAMINE-6-PHOSPHATE.","authors":"T S FOSTER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2141-6"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23666650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE SERUM GLYCOPROTEIN RESPONSE FOLLOWING X-IRRADIATION AND PRIMARY IMMUNIZATION IN THE RABBIT.","authors":"H E WEIMER, M B RITTENBERG, E L NELSON","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2147-56"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23666651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
16-Oxoestradiol-17β-16-C14 was injected intravenously into non-laying hens and the urine and feces for succeeding days were collected separately. Estrogen extracts were prepared using enzymic hydro...
{"title":"URINARY AND FECAL CONVERSION PRODUCTS OF 16-OXOESTRADIOL-17-BETA-16-C14 IN THE DOMESTIC FOWL.","authors":"L. Ainsworth, R. Common","doi":"10.1139/O63-234","DOIUrl":"https://doi.org/10.1139/O63-234","url":null,"abstract":"16-Oxoestradiol-17β-16-C14 was injected intravenously into non-laying hens and the urine and feces for succeeding days were collected separately. Estrogen extracts were prepared using enzymic hydro...","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"1 1","pages":"2045-55"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79779364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"POTASSIUM MOVEMENTS IN RAT UTERUS STUDIED IN VITRO. I. EFFECTS OF TEMPERATURE.","authors":"E E DANIEL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2065-84"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23666646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"POTASSIUM MOVEMENTS IN RAT UTERUS STUDIED IN VITRO. II. EFFECTS OF METABOLIC INHIBITORS, OUABAIN, AND ALTERED POTASSIUM CONCENTRATION.","authors":"E E DANIEL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2085-105"},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23666647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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