{"title":"ABSORPTION OF INJECTED OXIMES.","authors":"E E DUKE, C A DECANDOLE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2473-8"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23684165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EFFECTS OF PARATHYROID EXTRACT ON THE STOMACH OF THE CHICK.","authors":"L F BELANGER, B B MIGICOVSKY","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2547-9"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23684174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Concentrations in the blood of rabbits of 1,1′-trimethylene bis (4-formylpyridinium bromide) dioxime (TMB4), of 2-formyl-1-methylpyridinium chloride oxime (PAM Cl), and of 2-formyl-1-methylpyridinium methanesulphonate oxime (P2S) were measured at short intervals during the period immediately following intravenous or intramuscular injection. Dose for dose the concentration in the blood of TMB4 was found to be at least twofold higher than the concentration of either of the others. The rate of absorption from an intramuscular injection was the same for all three oximes, the peak concentration being reached in approximately 9 minutes.Other experiments, in which P2S was injected by the intrapulmonary route, showed no advantage in this species as regards speed of absorption over the intramuscular route.
{"title":"ABSORPTION OF INJECTED OXIMES.","authors":"E. Duke, C. A. Decandole","doi":"10.1139/O63-276","DOIUrl":"https://doi.org/10.1139/O63-276","url":null,"abstract":"Concentrations in the blood of rabbits of 1,1′-trimethylene bis (4-formylpyridinium bromide) dioxime (TMB4), of 2-formyl-1-methylpyridinium chloride oxime (PAM Cl), and of 2-formyl-1-methylpyridinium methanesulphonate oxime (P2S) were measured at short intervals during the period immediately following intravenous or intramuscular injection. Dose for dose the concentration in the blood of TMB4 was found to be at least twofold higher than the concentration of either of the others. The rate of absorption from an intramuscular injection was the same for all three oximes, the peak concentration being reached in approximately 9 minutes.Other experiments, in which P2S was injected by the intrapulmonary route, showed no advantage in this species as regards speed of absorption over the intramuscular route.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"14 1","pages":"2473-8"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89607194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EFFECT OF INSULIN ON THE DISTRIBUTION OF GLUCOSE BETWEEN THE BLOOD PLASMA AND THE LIVER IN ALLOXAN-DIABETIC AND ADRENALECTOMIZED RATS.","authors":"G HETENYI, F K KOPSTICK, L J RETELSTORF","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2431-9"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23684162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COMPONENT FATTY ACIDS OF THE MILK OF THE GREY (ATLANTIC) SEAL.","authors":"R G ACKMAN, R D BURGHER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2501-5"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23684168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE ROLE OF SODIUM IONS IN THE METABOLISM OF ACETYLCHOLINE.","authors":"R I BIRKS","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"41 ","pages":"2573-97"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23684177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A discussion of the factors involved in the physiological synthesis of acetylcholine in nerve endings, and of the action thereon of hemicholinium No. 3.
讨论了神经末梢乙酰胆碱生理合成的相关因素及3号半胆碱的作用。
{"title":"SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN NERVOUS TISSUE.","authors":"F. C. Macintosh","doi":"10.1139/O63-288","DOIUrl":"https://doi.org/10.1139/O63-288","url":null,"abstract":"A discussion of the factors involved in the physiological synthesis of acetylcholine in nerve endings, and of the action thereon of hemicholinium No. 3.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"14 1","pages":"2555-71"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90196714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In diabetic rats the concentration of glucose in the liver was less than in the plasma. The relative accumulation of glucose in the liver cell after the injection of insulin was also found to be significantly less in previously untreated diabetic than in normal rats. Pretreatment with insulin restored the response to normal. Experiments with labeled glucose indicated that the rate at which glucose is carried through the hepatic cell membrane is very high compared to the rate at which glucose is being formed in the liver cells in diabetic rats. The relatively small ;)mount of glucose acciimiilati~~g after insulin in livers of diabetic rats originates from the plasma. In adrenalectomized rats which have very little liver g.l,cogen, the relative accumulation of glucose in liver cells, following the inject1o11 of i~~bulin, was less than that in normals. These experiments indicate that in normal rats a large part of the glucose retained in the liver after the injection of i~isuli~l originates from non-labeled endogenous hepatic sources, presumably glycogen. In an earlier series of experinlents it was found that in rats the hepatic cell water contains glucose at a concentration 2075 higher than that of plasma water (1). 'The findings, that r at liver tissue contains about as much glucose as plasnia, have been confirnled (2, 3, 5). This concentration ratio has been reported to be increased by insulin (1). This observation was proposed as an explailatiorl for tlle mechanisill by which insulin increases the tracer-deternliiled apparent distribution space in normal, but not in diabetic dogs (4). The objchctive of the experiineilts presented below was to investigate whether diabetic rats respond differently to insulin than do normals with regard to the hepatic accuin~ilatio~l of glucose; and if so, to determine tlle nature of the difference. Methods
{"title":"THE EFFECT OF INSULIN ON THE DISTRIBUTION OF GLUCOSE BETWEEN THE BLOOD PLASMA AND THE LIVER IN ALLOXAN-DIABETIC AND ADRENALECTOMIZED RATS.","authors":"G. Hetenyi, F. K. Kopstick, L. J. Retelstorf","doi":"10.1139/O63-273","DOIUrl":"https://doi.org/10.1139/O63-273","url":null,"abstract":"In diabetic rats the concentration of glucose in the liver was less than in the plasma. The relative accumulation of glucose in the liver cell after the injection of insulin was also found to be significantly less in previously untreated diabetic than in normal rats. Pretreatment with insulin restored the response to normal. Experiments with labeled glucose indicated that the rate at which glucose is carried through the hepatic cell membrane is very high compared to the rate at which glucose is being formed in the liver cells in diabetic rats. The relatively small ;)mount of glucose acciimiilati~~g after insulin in livers of diabetic rats originates from the plasma. In adrenalectomized rats which have very little liver g.l,cogen, the relative accumulation of glucose in liver cells, following the inject1o11 of i~~bulin, was less than that in normals. These experiments indicate that in normal rats a large part of the glucose retained in the liver after the injection of i~isuli~l originates from non-labeled endogenous hepatic sources, presumably glycogen. In an earlier series of experinlents it was found that in rats the hepatic cell water contains glucose at a concentration 2075 higher than that of plasma water (1). 'The findings, that r at liver tissue contains about as much glucose as plasnia, have been confirnled (2, 3, 5). This concentration ratio has been reported to be increased by insulin (1). This observation was proposed as an explailatiorl for tlle mechanisill by which insulin increases the tracer-deternliiled apparent distribution space in normal, but not in diabetic dogs (4). The objchctive of the experiineilts presented below was to investigate whether diabetic rats respond differently to insulin than do normals with regard to the hepatic accuin~ilatio~l of glucose; and if so, to determine tlle nature of the difference. Methods","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"53 1","pages":"2431-9"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77767651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rectal temperature in male rats fell slowly and gradually from ad libitum and pair-led control levels throughout a thiamine depletion period. During this period, food consumption dropped suddenly and sharply to a minimal level. A single oral dose of 50 μg of thiamine hydrochloride produced, within 4 hours, a significant rise (to less than control levels) in rectal temperature and an increase in food consumption within 24 hours. The increase in temperature was independent of the ingestion of food since diet was withheld during the 4 hours following thiamine administration. Subsequent feeding of control diet (containing thiamine) had not further increased the "4-hour" temperature after 24 hours. With continued feeding of control diet, rectal temperature rose to control levels after 3 days. On subsequent withdrawal of dietary thiamine from the deficient group, temperature and food consumption fell as before. When the animals were again repleted with 50 μg thiamine and deficient diet was continued, temperatur...
{"title":"FOOD CONSUMPTION AND RECTAL TEMPERATURE IN RATS DURING THIAMINE DEFICIENCY AND REPLETION.","authors":"M. J. Veen, G. Russel, G. Beaton","doi":"10.1139/O63-275","DOIUrl":"https://doi.org/10.1139/O63-275","url":null,"abstract":"Rectal temperature in male rats fell slowly and gradually from ad libitum and pair-led control levels throughout a thiamine depletion period. During this period, food consumption dropped suddenly and sharply to a minimal level. A single oral dose of 50 μg of thiamine hydrochloride produced, within 4 hours, a significant rise (to less than control levels) in rectal temperature and an increase in food consumption within 24 hours. The increase in temperature was independent of the ingestion of food since diet was withheld during the 4 hours following thiamine administration. Subsequent feeding of control diet (containing thiamine) had not further increased the \"4-hour\" temperature after 24 hours. With continued feeding of control diet, rectal temperature rose to control levels after 3 days. On subsequent withdrawal of dietary thiamine from the deficient group, temperature and food consumption fell as before. When the animals were again repleted with 50 μg thiamine and deficient diet was continued, temperatur...","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"84 1","pages":"2463-71"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75416974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Injection of the catecholamines, and particularly adrenaline, has been found always to depress synaptic transmission in a sympathetic ganglion. Although an adrenaline-like substance is released upon preganglionic stimulation, this is not believed to have any physiological significance.
{"title":"THE ACTION OF CATECHOLAMINES IN SYMPATHETIC GANGLIA.","authors":"M. C. Weir, H. Mclennan","doi":"10.1139/Y63-293","DOIUrl":"https://doi.org/10.1139/Y63-293","url":null,"abstract":"Injection of the catecholamines, and particularly adrenaline, has been found always to depress synaptic transmission in a sympathetic ganglion. Although an adrenaline-like substance is released upon preganglionic stimulation, this is not believed to have any physiological significance.","PeriodicalId":9531,"journal":{"name":"Canadian journal of biochemistry and physiology","volume":"15 1","pages":"2627-36"},"PeriodicalIF":0.0,"publicationDate":"1963-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73507596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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