Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3776
E. A. Zakharyan, A. Ushakov
Aim. To determine the relationship between the serum level of neu-regulin-1 (NRG-1) and the severity of coronary artery (CA) atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease (CAD).Material and methods. The study included 264 people, of which 220 were patients diagnosed with coronary CAD. The patients underwent coronary angiography using the Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX) score and echocardiography. The patients were divided into groups according to SYNTAX score: group 1 — with moderate CA atherosclerosis (≤22 (n=124); group 2 — with severe CA atherosclerosis (23-32) (n=53); group 3 — with extremely severe CA atherosclerosis (≥33) (n=43). Group 4 was represented by healthy volunteers (n=44). All subjects underwent a study of the serum NRG-1 (ng/ml) level. Statistical processing of the results was carried out using Statistica 10.0 software. Differences were considered significant at p<0,05.Results. Significantly higher NRG-1 values were obtained in the control group compared to patients with CAD (p<0,001). An inverse correlation was found between the NRG-1 concentration and the severity of CA atherosclerosis (p<0,001). A decrease in NRG-1 concentration is associated with a high functional class of = heart failure (p<0,01) and low left ventricular ejection fraction (p<0,001). The significance of NRG-1 differences between groups of patients with a history of myocardial infarction (p<0,001), angina pectoris (p<0,01), permanent atrial fibrillation (p<0,01), chronic left ventricular aneurysm (p<0,01) and repeated myocardial infarction (p<0,05) in comparison with patients without these pathologies.Conclusion. The identified correlations between the NRG-1 concentration and CAD, as well as the clinical and paraclinical characteristics of patients, makes it possible to consider NRG-1 as a reliable biomarker of CA and heart failure severity and may form the basis for the development of novel diagnostic approaches.
{"title":"Serum levels of neuregulin-1 in patients with coronary artery disease: clinical and pathogenetic aspects","authors":"E. A. Zakharyan, A. Ushakov","doi":"10.15829/1728-8800-2024-3776","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3776","url":null,"abstract":"Aim. To determine the relationship between the serum level of neu-regulin-1 (NRG-1) and the severity of coronary artery (CA) atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease (CAD).Material and methods. The study included 264 people, of which 220 were patients diagnosed with coronary CAD. The patients underwent coronary angiography using the Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX) score and echocardiography. The patients were divided into groups according to SYNTAX score: group 1 — with moderate CA atherosclerosis (≤22 (n=124); group 2 — with severe CA atherosclerosis (23-32) (n=53); group 3 — with extremely severe CA atherosclerosis (≥33) (n=43). Group 4 was represented by healthy volunteers (n=44). All subjects underwent a study of the serum NRG-1 (ng/ml) level. Statistical processing of the results was carried out using Statistica 10.0 software. Differences were considered significant at p<0,05.Results. Significantly higher NRG-1 values were obtained in the control group compared to patients with CAD (p<0,001). An inverse correlation was found between the NRG-1 concentration and the severity of CA atherosclerosis (p<0,001). A decrease in NRG-1 concentration is associated with a high functional class of = heart failure (p<0,01) and low left ventricular ejection fraction (p<0,001). The significance of NRG-1 differences between groups of patients with a history of myocardial infarction (p<0,001), angina pectoris (p<0,01), permanent atrial fibrillation (p<0,01), chronic left ventricular aneurysm (p<0,01) and repeated myocardial infarction (p<0,05) in comparison with patients without these pathologies.Conclusion. The identified correlations between the NRG-1 concentration and CAD, as well as the clinical and paraclinical characteristics of patients, makes it possible to consider NRG-1 as a reliable biomarker of CA and heart failure severity and may form the basis for the development of novel diagnostic approaches.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"44 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2023-3836
S. Orlov, R. Shepel, D. V. Voshev, D. O. Savchenko, D. A. Gellekh, А. B. Gorlov, K. Mezhidov, M. V. Turlay, A. V. Sentsova, L. M. Zhamalov, A. Kontsevaya, O. Drapkina
The distribution of publications posted in the Elibrary for the period from January 1, 2012 to December 31, 2022, in the structure of a cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation made it possible to establish areas of scientific interest and identify gaps in specific areas and indicators characterizing its current and future development.Aim. To distribute scientific publications according to the relevant segments of the cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation.Material and methods. A database of 41824 publications was used, for which a triple review was carried out with the involvement of 9 experts selected according to appropriate criteria for level of education, work experience in the healthcare system, and academic credentials. At the first two stages, publications not related to primary health care, as well as duplicate publications, were excluded. At the final stage of reviewing, a selective analysis of publications was carried out, assessing the correctness of their distribution into the corresponding taxa of the cognitive matrix, followed by adjustment (if necessary).Results. A cognitive matrix of taxonomic characteristics has been generated for the analysis and assessment of primary health care in the Russian Federation, containing 30339 publications distributed across relevant domains, subdomains and primary health care indicators. The matrix is also presented in a heat map format, allowing an assessment of the most studied taxa of primary health care, as well as highlighting those areas in primary health care in which more research should be carried out to provide a basis and methodology for making informed decisions on its development.Conclusion. Systematized and ordered publications can serve as a basis for a wide range of users in the preparation of systematic reviews and other publications on specific domains, subdomains, primary health care indicators and universal health coverage principles. This study has shown the high efficiency of the cognitive matrix of taxonomic characteristics as a unified tool for aggregation or decomposition of features characterizing the development of primary health care in the Russian Federation.
{"title":"Cognitive-matrix analysis of research on primary health care development in the Russian Federation for the period from 2012 to 2022","authors":"S. Orlov, R. Shepel, D. V. Voshev, D. O. Savchenko, D. A. Gellekh, А. B. Gorlov, K. Mezhidov, M. V. Turlay, A. V. Sentsova, L. M. Zhamalov, A. Kontsevaya, O. Drapkina","doi":"10.15829/1728-8800-2023-3836","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3836","url":null,"abstract":"The distribution of publications posted in the Elibrary for the period from January 1, 2012 to December 31, 2022, in the structure of a cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation made it possible to establish areas of scientific interest and identify gaps in specific areas and indicators characterizing its current and future development.Aim. To distribute scientific publications according to the relevant segments of the cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation.Material and methods. A database of 41824 publications was used, for which a triple review was carried out with the involvement of 9 experts selected according to appropriate criteria for level of education, work experience in the healthcare system, and academic credentials. At the first two stages, publications not related to primary health care, as well as duplicate publications, were excluded. At the final stage of reviewing, a selective analysis of publications was carried out, assessing the correctness of their distribution into the corresponding taxa of the cognitive matrix, followed by adjustment (if necessary).Results. A cognitive matrix of taxonomic characteristics has been generated for the analysis and assessment of primary health care in the Russian Federation, containing 30339 publications distributed across relevant domains, subdomains and primary health care indicators. The matrix is also presented in a heat map format, allowing an assessment of the most studied taxa of primary health care, as well as highlighting those areas in primary health care in which more research should be carried out to provide a basis and methodology for making informed decisions on its development.Conclusion. Systematized and ordered publications can serve as a basis for a wide range of users in the preparation of systematic reviews and other publications on specific domains, subdomains, primary health care indicators and universal health coverage principles. This study has shown the high efficiency of the cognitive matrix of taxonomic characteristics as a unified tool for aggregation or decomposition of features characterizing the development of primary health care in the Russian Federation.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"69 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3884
M. Skhirtladze, E. A. Losik, E. Bueverova, A. S. Cherenda
Introduction. Left ventricular noncompaction (LVNC) is a rare heterogeneous pathology characterized by a two-layered structure with a predominance of non-compact layer in the form of multiple trabeculations and pockets between them, communicating with the left ventricular cavity. One of the rare LVNC phenotypes is a combination with congenital heart defects, including atrial septal defect (ASD).Brief description. The article presents a case report describing the difficulties of selecting antiarrhythmic therapy in a patient with LVNC and ASD, complicated by arrhythmias due to heart failure. The diagnosis of LVNC was confirmed by the Petersen criterion using magnetic resonance imaging.Discussion. Cardiac arrhythmias in patients with LVNC and congenital heart defects, as a result of both anatomical and hemodynamic causes of electrical heart instability, constitute a danger of thromboembolism and sudden cardiac death, and also contribute to heart failure progression. The case is of interest due to the rare combination of LVNC and ASD, complicated by frequent episodes atrial fibrillation and premature ventricular contractions in the form of parasystoles, as well as difficulties in selecting antiarrhythmic therapy. Pulmonary vein cryoballoon ablation eliminated the source of atrial fibrillation. Ventricular ectopic activity was stopped using the anticonvulsant drug carbamazepine.
{"title":"Difficulties in selecting antiarrhythmic therapy in a patient with left ventricular noncompaction and atrial septal defect: a case report","authors":"M. Skhirtladze, E. A. Losik, E. Bueverova, A. S. Cherenda","doi":"10.15829/1728-8800-2024-3884","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3884","url":null,"abstract":"Introduction. Left ventricular noncompaction (LVNC) is a rare heterogeneous pathology characterized by a two-layered structure with a predominance of non-compact layer in the form of multiple trabeculations and pockets between them, communicating with the left ventricular cavity. One of the rare LVNC phenotypes is a combination with congenital heart defects, including atrial septal defect (ASD).Brief description. The article presents a case report describing the difficulties of selecting antiarrhythmic therapy in a patient with LVNC and ASD, complicated by arrhythmias due to heart failure. The diagnosis of LVNC was confirmed by the Petersen criterion using magnetic resonance imaging.Discussion. Cardiac arrhythmias in patients with LVNC and congenital heart defects, as a result of both anatomical and hemodynamic causes of electrical heart instability, constitute a danger of thromboembolism and sudden cardiac death, and also contribute to heart failure progression. The case is of interest due to the rare combination of LVNC and ASD, complicated by frequent episodes atrial fibrillation and premature ventricular contractions in the form of parasystoles, as well as difficulties in selecting antiarrhythmic therapy. Pulmonary vein cryoballoon ablation eliminated the source of atrial fibrillation. Ventricular ectopic activity was stopped using the anticonvulsant drug carbamazepine.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"38 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3890
F. B. Shukurov, R. Myasnikov, O. Kulikova, D. A. Nefedova, D. Feshchenko, D. Vasiliev
The revascularization strategy for severe calcification is one of the most pressing problems of modern percutaneous coronary interventions, since it is observed more and more often and significantly complicates traditional endovascular treatment. Currently, the method of choice for severe coronary calcification is rotational atherectomy, which allows modification of atheromatous mass with an increase in the vessel lumen to allow satisfactory balloon angioplasty and stenting. This article presents a case of a patient at very high cardiovascular risk with a burdened coronary history and severe clinical symptoms of exertional angina while receiving the optimal multiagent therapy. The examination revealed a multivessel coronary calcification, but the patient was denied coronary artery bypass grafting due to high perioperative risks. SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery score) score I – 25,5 points, SYNTAX score II — 40,4% and 70,1% for percutaneous coronary intervention and coronary bypass surgery, respectively, European System for Cardiac Operative Risk Evaluation (EuroSCORE II) — 4,95%. Attempts at traditional percutaneous intervention were unsuccessful and the patient underwent endovascular rotational atherectomy followed by stenting of affected coronary segments, against the background of which there was an improvement in exercise tolerance with a decrease in angina class.
{"title":"Endovascular rotational atherectomy for multivessel coronary calcification involving the main trunk of left coronary artery and the left anterior descending artery","authors":"F. B. Shukurov, R. Myasnikov, O. Kulikova, D. A. Nefedova, D. Feshchenko, D. Vasiliev","doi":"10.15829/1728-8800-2024-3890","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3890","url":null,"abstract":"The revascularization strategy for severe calcification is one of the most pressing problems of modern percutaneous coronary interventions, since it is observed more and more often and significantly complicates traditional endovascular treatment. Currently, the method of choice for severe coronary calcification is rotational atherectomy, which allows modification of atheromatous mass with an increase in the vessel lumen to allow satisfactory balloon angioplasty and stenting. This article presents a case of a patient at very high cardiovascular risk with a burdened coronary history and severe clinical symptoms of exertional angina while receiving the optimal multiagent therapy. The examination revealed a multivessel coronary calcification, but the patient was denied coronary artery bypass grafting due to high perioperative risks. SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery score) score I – 25,5 points, SYNTAX score II — 40,4% and 70,1% for percutaneous coronary intervention and coronary bypass surgery, respectively, European System for Cardiac Operative Risk Evaluation (EuroSCORE II) — 4,95%. Attempts at traditional percutaneous intervention were unsuccessful and the patient underwent endovascular rotational atherectomy followed by stenting of affected coronary segments, against the background of which there was an improvement in exercise tolerance with a decrease in angina class.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"168 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2023-3712
R. Shepel, A. A. Svishcheva, V. P. Lusnikov, A. Kontsevaya, O. Drapkina
Aim. To analyze hospitalizations and outpatient visits to primary health care facilities of patients aged 18 years and older with chronic coronary artery disease (CAD) by federal districts and the constituent entities of the Russian Federation from the perspective of the World Health Organization concept for diseases treating mainly on an outpatient basis.Material and methods. We used data from Federal Statistical Monitoring for 2022 on the number of diseases, hospitalizations and the number of outpatient visits of patients aged 18 years and older with an established diagnosis of CAD (ICD 10:I25).Results. In the Central, Southern and Northwestern Federal Districts, the hospitalizations and outpatient visits of the adult population with chronic CAD were higher, and in the North Caucasus, Far Eastern and Ural Federal Districts — below the Russian average level. In the Volga Federal District, the outpatient visits with chronic CAD were higher than the Russian average, and the hospitalizations were below the Russian average. In the Siberian Federal District, the outpatient visits were lower, and the hospitalizations were higher than the Russian average level. When analyzing the ratio of hospitalization rate to the number of outpatient visits of the adult population with an established chronic CAD in the primary health care unit, characterizing the availability, quality and efficiency of outpatient care, the highest indicator was recorded in the Siberian Federal District, while its heterogeneity within the federal district was the highest in comparison with other federal districts. Its lowest was recorded in the Southern Federal District, while heterogeneity within the federal district was the lowest in comparison with other federal districts. The values of this parameter varied from 3,67 in the Kurgan Oblast to 38,33 in the Republic of Tuva.Conclusion. Accounting for diseases treating primarily on an outpatient basis can become one of the tools for assessing the quality of adult primary health care. However, before including this indicator in the criteria for assessing the quality of medical services, a deeper understanding of the reasons influencing its change is required.
{"title":"Chronic coronary artery disease: regional characteristics of outpatient visits and hospitalizations of the Russian adult population","authors":"R. Shepel, A. A. Svishcheva, V. P. Lusnikov, A. Kontsevaya, O. Drapkina","doi":"10.15829/1728-8800-2023-3712","DOIUrl":"https://doi.org/10.15829/1728-8800-2023-3712","url":null,"abstract":"Aim. To analyze hospitalizations and outpatient visits to primary health care facilities of patients aged 18 years and older with chronic coronary artery disease (CAD) by federal districts and the constituent entities of the Russian Federation from the perspective of the World Health Organization concept for diseases treating mainly on an outpatient basis.Material and methods. We used data from Federal Statistical Monitoring for 2022 on the number of diseases, hospitalizations and the number of outpatient visits of patients aged 18 years and older with an established diagnosis of CAD (ICD 10:I25).Results. In the Central, Southern and Northwestern Federal Districts, the hospitalizations and outpatient visits of the adult population with chronic CAD were higher, and in the North Caucasus, Far Eastern and Ural Federal Districts — below the Russian average level. In the Volga Federal District, the outpatient visits with chronic CAD were higher than the Russian average, and the hospitalizations were below the Russian average. In the Siberian Federal District, the outpatient visits were lower, and the hospitalizations were higher than the Russian average level. When analyzing the ratio of hospitalization rate to the number of outpatient visits of the adult population with an established chronic CAD in the primary health care unit, characterizing the availability, quality and efficiency of outpatient care, the highest indicator was recorded in the Siberian Federal District, while its heterogeneity within the federal district was the highest in comparison with other federal districts. Its lowest was recorded in the Southern Federal District, while heterogeneity within the federal district was the lowest in comparison with other federal districts. The values of this parameter varied from 3,67 in the Kurgan Oblast to 38,33 in the Republic of Tuva.Conclusion. Accounting for diseases treating primarily on an outpatient basis can become one of the tools for assessing the quality of adult primary health care. However, before including this indicator in the criteria for assessing the quality of medical services, a deeper understanding of the reasons influencing its change is required.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"57 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3874
I. Samorodskaya, M. Bubnova, O. A. Akulova
Aim. To assess the changes of mortality from acute coronary artery disease (CAD) in the Russian regions during the coronavirus disease 2019 (COVID-19) pandemic in 2020-2022 in comparison with the prepandemic period (2017-2019).Material and methods. Rosstat data on the average annual population and mortality rate in one-year age groups for 82 regions Russian were used. In the brief Nomenclature of Causes of Death of Rosstat, the codes of the International Classification of Diseases, 10th revision (ICD-10) are grouped as follows: I21.0-9 (acute primary) myocardial infarction (MI), I22.0-9 (recurrent MI), I20, I24.1-9 (other types of acute coronary artery disease), U07.1 and U07.2 (coronavirus disease 2019 (COVID-19)). The regional average standardized mortality rates (SMR; M±SD) were calculated using the European population standard using the direct standardization method per 100 thousand population. Comparisons were made using the nonparametric Wilcoxon t-test (differences were considered significant at p<0,05).Results. A decrease in the regional average SMR (per 100 thousand population) in the pandemic compared to the pre-pandemic period was revealed: from the sum of all acute CAD types — from 51,24±31,98 to 50,21±33,38 and from repeated MI — from 7,65±5,42 to 4,80±4,84; increase in SMR from acute MI — from 24,00±10,1 to 25,57±11,55, from other acute CAD types — from 19,58±25,23 to 19,83±26,21. Significant regional variability was noted in both the dynamics of the SMR from three acute CAD types, as well as the minimum and maximum SMR. Only in 2 regions in the pandemic period there was an increase in SMR from each of the three acute CAD types compared to the pre-pandemic period. In 18 regions, there was a decrease in SMR from each of the three forms, and in the rest, multidirectional changes were noted. There was no correlation between SMR for COVID-19 and SMR for acute CAD (r=0,034; p=0,76).Conclusion. The COVID-19 pandemic did not have a significant impact on the regional average SMR from acute CAD. The significant decrease in SMR from recurrent MI is likely due to choice of the initial cause of death.
{"title":"Has COVID-19 affected regional mortality from acute coronary artery disease? (comparison of two periods of 2017-2019 and 2020-2022)","authors":"I. Samorodskaya, M. Bubnova, O. A. Akulova","doi":"10.15829/1728-8800-2024-3874","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3874","url":null,"abstract":"Aim. To assess the changes of mortality from acute coronary artery disease (CAD) in the Russian regions during the coronavirus disease 2019 (COVID-19) pandemic in 2020-2022 in comparison with the prepandemic period (2017-2019).Material and methods. Rosstat data on the average annual population and mortality rate in one-year age groups for 82 regions Russian were used. In the brief Nomenclature of Causes of Death of Rosstat, the codes of the International Classification of Diseases, 10th revision (ICD-10) are grouped as follows: I21.0-9 (acute primary) myocardial infarction (MI), I22.0-9 (recurrent MI), I20, I24.1-9 (other types of acute coronary artery disease), U07.1 and U07.2 (coronavirus disease 2019 (COVID-19)). The regional average standardized mortality rates (SMR; M±SD) were calculated using the European population standard using the direct standardization method per 100 thousand population. Comparisons were made using the nonparametric Wilcoxon t-test (differences were considered significant at p<0,05).Results. A decrease in the regional average SMR (per 100 thousand population) in the pandemic compared to the pre-pandemic period was revealed: from the sum of all acute CAD types — from 51,24±31,98 to 50,21±33,38 and from repeated MI — from 7,65±5,42 to 4,80±4,84; increase in SMR from acute MI — from 24,00±10,1 to 25,57±11,55, from other acute CAD types — from 19,58±25,23 to 19,83±26,21. Significant regional variability was noted in both the dynamics of the SMR from three acute CAD types, as well as the minimum and maximum SMR. Only in 2 regions in the pandemic period there was an increase in SMR from each of the three acute CAD types compared to the pre-pandemic period. In 18 regions, there was a decrease in SMR from each of the three forms, and in the rest, multidirectional changes were noted. There was no correlation between SMR for COVID-19 and SMR for acute CAD (r=0,034; p=0,76).Conclusion. The COVID-19 pandemic did not have a significant impact on the regional average SMR from acute CAD. The significant decrease in SMR from recurrent MI is likely due to choice of the initial cause of death.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3784
G. Gimatdinova, O. Danilova, I. Davydkin, U. Dzhulakyan, E. V. Usenko
Aim. To study the possibilities of instrumental research methods in relation to the earliest detection of cardiovascular events in oncohematological patients receiving antitumor immunochemotherapy, as well as to determine the requirements for documenting adverse events.Material and methods. For the study, 63 patients were prospectively selected with a diagnosis of indolent non-Hodgkin lymphoma, who were indicated for antitumor immunochemotherapy. The patients were examined in three stages (before treatment, after 3 and 6 cycles of therapy) and divided into 2 groups by simple randomization. Cardiovascular toxicity in the main group of patients was assessed using 3D transthoracic echocardiography, analysis of left ventricular (LV) global longitudinal systolic strain and electrocardiography. The control group underwent a standard 3D echocardiography with analysis of LV ejection fraction. Clinical manifestations of cardiovascular events were assessed in all patients during treatment.Results. According to the study, significant changes were obtained in LV ejection fraction on the third visit — a decrease from 58,9±1,07 to 48,1±0,73% (p<0,05) and from 57,7±1,13 to 49,4±0,58% (p<0,05) in patients of the main and control groups and global longitudinal LV strain from |21,1±1,18 to |14,0±1,61 |% (p<0,05) in patients of the main group. A mixed clinical phenotype of cardiovascular toxicity was the most common among all patients. An integrated approach to the early diagnosis of cardiovascular events makes it possible to identify a larger percentage of patients with subclinical myocardial dysfunction.Conclusion. The long period of latent cardiovascular toxicity emphasizes the need for early verification of cardiovascular complications of antitumor therapy and expansion of the established paraclinical diagnostic minimum. In addition, taking into account the accumulated experience, recommendations are presented for the preparation of medical documentation in order to ensure the safety and quality of care.
{"title":"Diagnostic capabilities of instrumental methods for studying early cardiovascular adverse events in patients with lymphoproliferative disorders, quality and safety issues","authors":"G. Gimatdinova, O. Danilova, I. Davydkin, U. Dzhulakyan, E. V. Usenko","doi":"10.15829/1728-8800-2024-3784","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3784","url":null,"abstract":"Aim. To study the possibilities of instrumental research methods in relation to the earliest detection of cardiovascular events in oncohematological patients receiving antitumor immunochemotherapy, as well as to determine the requirements for documenting adverse events.Material and methods. For the study, 63 patients were prospectively selected with a diagnosis of indolent non-Hodgkin lymphoma, who were indicated for antitumor immunochemotherapy. The patients were examined in three stages (before treatment, after 3 and 6 cycles of therapy) and divided into 2 groups by simple randomization. Cardiovascular toxicity in the main group of patients was assessed using 3D transthoracic echocardiography, analysis of left ventricular (LV) global longitudinal systolic strain and electrocardiography. The control group underwent a standard 3D echocardiography with analysis of LV ejection fraction. Clinical manifestations of cardiovascular events were assessed in all patients during treatment.Results. According to the study, significant changes were obtained in LV ejection fraction on the third visit — a decrease from 58,9±1,07 to 48,1±0,73% (p<0,05) and from 57,7±1,13 to 49,4±0,58% (p<0,05) in patients of the main and control groups and global longitudinal LV strain from |21,1±1,18 to |14,0±1,61 |% (p<0,05) in patients of the main group. A mixed clinical phenotype of cardiovascular toxicity was the most common among all patients. An integrated approach to the early diagnosis of cardiovascular events makes it possible to identify a larger percentage of patients with subclinical myocardial dysfunction.Conclusion. The long period of latent cardiovascular toxicity emphasizes the need for early verification of cardiovascular complications of antitumor therapy and expansion of the established paraclinical diagnostic minimum. In addition, taking into account the accumulated experience, recommendations are presented for the preparation of medical documentation in order to ensure the safety and quality of care.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"32 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3767
V. Gafarov, E. Gromova, E. Kashtanova, I. Gagulin, Y. Polonskaya, A. Gafarova, Yulia I. Ragino
Aim. To study the association of interleukin-6 (IL-6) levels with depression and stress at work among young people (25-44 years old) in Novosibirsk.Material and methods. A random representative sample of young people (25-44 years old) in Novosibirsk was surveyed (975 people of both sexes; response rate, 71%) in 2013-2016 on the basis of Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics (FWNR-2024-0002). All respondents signed informed consent. The World Health Organization MONICA-Psychosocial (MOPSY) scale was used to assess depression. Work-related stress was determined using the Karasek’s scale included in the program protocol. Quantitative determination of IL-6 was carried out in the laboratory of clinical biochemical and hormonal studies of therapeutic diseases of the Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics.Results. High level of depression among people of both sexes aged 25-44 years were 11,9% (among men — 8,5%, among women — 14,6%). The level of IL-6 was higher in individuals of both sexes with high level of depression — 1,33 [0,72;3,92] pg/ml than without depression — 1,16 [0,63;2,37] pg/ml) (p=0,002). In women with high level of depression, IL-6 value was higher (1,31 [0,72;3,86] pg/ml) than in those without depression (1 [0,53;2,03] pg/ml) or a moderate depression — 1,06 [0,58;2,14] pg/ml, (p=0,002). The level of IL-6 was higher among people of both sexes who had changed occupation within the last 12 months (1,4 [0,67;3,58] pg/ml) than among those who had no changes — 1,12 [0,63;2,04] pg/ml. Among participants who assessed their work responsibility as very high, the median levels of serum IL-6 were higher (1,7 [0,72;5,48] pg/ml), than among people with high work load (1,37 [0,58;5,18] pg/ml), as well as with a moderate (1,21 [0,63;2,5] pg/ml) and a slight (1,09 [0,63;1,98] pg/ml) work load.Conclusion. A significantly higher level of IL-6 was found in depression and workplace stress among young people (25-44 years old) compared to people without depression and not experiencing workplace stress.
{"title":"Acute phase mediator interleukin-6 and depression, work-related stress among young people (25-44 years old)","authors":"V. Gafarov, E. Gromova, E. Kashtanova, I. Gagulin, Y. Polonskaya, A. Gafarova, Yulia I. Ragino","doi":"10.15829/1728-8800-2024-3767","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3767","url":null,"abstract":"Aim. To study the association of interleukin-6 (IL-6) levels with depression and stress at work among young people (25-44 years old) in Novosibirsk.Material and methods. A random representative sample of young people (25-44 years old) in Novosibirsk was surveyed (975 people of both sexes; response rate, 71%) in 2013-2016 on the basis of Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics (FWNR-2024-0002). All respondents signed informed consent. The World Health Organization MONICA-Psychosocial (MOPSY) scale was used to assess depression. Work-related stress was determined using the Karasek’s scale included in the program protocol. Quantitative determination of IL-6 was carried out in the laboratory of clinical biochemical and hormonal studies of therapeutic diseases of the Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics.Results. High level of depression among people of both sexes aged 25-44 years were 11,9% (among men — 8,5%, among women — 14,6%). The level of IL-6 was higher in individuals of both sexes with high level of depression — 1,33 [0,72;3,92] pg/ml than without depression — 1,16 [0,63;2,37] pg/ml) (p=0,002). In women with high level of depression, IL-6 value was higher (1,31 [0,72;3,86] pg/ml) than in those without depression (1 [0,53;2,03] pg/ml) or a moderate depression — 1,06 [0,58;2,14] pg/ml, (p=0,002). The level of IL-6 was higher among people of both sexes who had changed occupation within the last 12 months (1,4 [0,67;3,58] pg/ml) than among those who had no changes — 1,12 [0,63;2,04] pg/ml. Among participants who assessed their work responsibility as very high, the median levels of serum IL-6 were higher (1,7 [0,72;5,48] pg/ml), than among people with high work load (1,37 [0,58;5,18] pg/ml), as well as with a moderate (1,21 [0,63;2,5] pg/ml) and a slight (1,09 [0,63;1,98] pg/ml) work load.Conclusion. A significantly higher level of IL-6 was found in depression and workplace stress among young people (25-44 years old) compared to people without depression and not experiencing workplace stress.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3782
A. S. Tereshchenko, E. V. Merkulov
The literature review is devoted to the pathophysiology and clinical picture of migraine, targets of therapy and drugs used, and the connection between the pathogenesis of migraine with aura and patent foramen ovale is discussed. The results of clinical studies show a positive effect of endovascular patent foramen ovale closure on the course of migraine in the form of a decrease in the intensity, frequency of attacks and the number of headache-free days, as well as in some cases complete relief of the disease. Further study of the topic is promising, but requires careful study design and long-term follow-up of patients.
{"title":"Migraine and endovascular closure of patent foramen ovale as a method of its treatment: a literature review","authors":"A. S. Tereshchenko, E. V. Merkulov","doi":"10.15829/1728-8800-2024-3782","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3782","url":null,"abstract":"The literature review is devoted to the pathophysiology and clinical picture of migraine, targets of therapy and drugs used, and the connection between the pathogenesis of migraine with aura and patent foramen ovale is discussed. The results of clinical studies show a positive effect of endovascular patent foramen ovale closure on the course of migraine in the form of a decrease in the intensity, frequency of attacks and the number of headache-free days, as well as in some cases complete relief of the disease. Further study of the topic is promising, but requires careful study design and long-term follow-up of patients.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"39 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.15829/1728-8800-2024-3866
A. O. Shevchenko, Y. Yufereva, Yu. A. Gerasimova, R. G. Timofeev, R. A. Faradzhov
Aim. To establish the prevalence and markers of masked hypertension (HTN) in apparently healthy young people.Material and methods. The cross-sectional study included young people (20-30 years old) with health group I or II, with clinical blood pressure (BP) <140/90 mm Hg. All participants underwent 24-hour blood pressure monitoring, assessment of traditional cardiovascular risk factors and ways of coping with stress.Results. A total of 347 participants were included (mean age, 22 (21-23) years; male, 101 (29,1%)). After 24-hour blood pressure monitoring, masked HTN was detected in 46 (13,3%) participants. Multivariate analysis found following markers of masked HTN: office systolic blood pressure (adjusted odds ratio (AOR) 1,109; p<0,001), resting heart rate (AOR 1,051; p=0,021), body mass index ≥25 kg/m2 (AOR 2,345; p=0,039), two models of coping with stress — distancing (AOR 1,071; p=0,001) and self-control (AOR 0,951; p=0,012). These parameters are included in the formula for calculating the masked HTN probability.Conclusion. Masked HTN occurs in 13,3% of apparently healthy young people. Associations of masked HTN with strategies for coping with stress have been established, which allows them to be regarded as novel markers of masked HTN. The method described in the article makes it possible to identify masked HTN with a high probability in young people.
{"title":"Stress coping strategies — novel markers in the diagnosis of masked hypertension in young people","authors":"A. O. Shevchenko, Y. Yufereva, Yu. A. Gerasimova, R. G. Timofeev, R. A. Faradzhov","doi":"10.15829/1728-8800-2024-3866","DOIUrl":"https://doi.org/10.15829/1728-8800-2024-3866","url":null,"abstract":"Aim. To establish the prevalence and markers of masked hypertension (HTN) in apparently healthy young people.Material and methods. The cross-sectional study included young people (20-30 years old) with health group I or II, with clinical blood pressure (BP) <140/90 mm Hg. All participants underwent 24-hour blood pressure monitoring, assessment of traditional cardiovascular risk factors and ways of coping with stress.Results. A total of 347 participants were included (mean age, 22 (21-23) years; male, 101 (29,1%)). After 24-hour blood pressure monitoring, masked HTN was detected in 46 (13,3%) participants. Multivariate analysis found following markers of masked HTN: office systolic blood pressure (adjusted odds ratio (AOR) 1,109; p<0,001), resting heart rate (AOR 1,051; p=0,021), body mass index ≥25 kg/m2 (AOR 2,345; p=0,039), two models of coping with stress — distancing (AOR 1,071; p=0,001) and self-control (AOR 0,951; p=0,012). These parameters are included in the formula for calculating the masked HTN probability.Conclusion. Masked HTN occurs in 13,3% of apparently healthy young people. Associations of masked HTN with strategies for coping with stress have been established, which allows them to be regarded as novel markers of masked HTN. The method described in the article makes it possible to identify masked HTN with a high probability in young people.","PeriodicalId":9545,"journal":{"name":"Cardiovascular Therapy and Prevention","volume":"42 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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