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Temporal Trends in Type 1, Type 2, and Gestational Diabetes in Pregnancy: Impact of Rural Residence, Ethnicity, and Material Deprivation 妊娠期 1 型、2 型和妊娠糖尿病的时间趋势:农村居民、种族和物质匮乏的影响
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.007
Deliwe P. Ngwezi MBChB, PhD , Anamaria Savu PhD , Roseanne O. Yeung MD, FRCPC, MPH , Sonia Butalia BSc, MD, FRCPC, MSc (Epi) , Padma Kaul PhD

Objective

Our aim in this study was to implement a newly validated algorithm to identify pregnant women with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM), and to identify temporal trends in rates over the last decade. We also compared obstetric and neonatal outcomes of pregnancies with and without diabetes mellitus (DM).

Methods

Among women with live births between 2005 and 2018 in Alberta, we calculated yearly rates of T1DM, T2DM, and GDM, overall, and stratified by ethnicity, urban or rural residence, material deprivation score, and maternal age.

Results

Between 2005 and 2018, GDM rates increased from 42.3 to 101.8 per 1,000 deliveries (p<0.0001), T2DM rates increased from 2.6 to 6.4 per 1,000 deliveries (p<0.0001), whereas T1DM remained constant at 3.0 per 1,000 deliveries each year (p=0.4301). Higher GDM and T2DM rates were observed among Chinese and South Asian women, respectively, and among women who were materially deprived and living in urban areas. Women with T2DM were older and had the highest rates of pre-existing hypertension (16%). In contrast, women with T1DM were younger and had the highest rates of gestational hypertension (12%), pre-eclampsia (12%), and cesarean section deliveries (62%). Children of women with T1DM had the highest rates of large for gestational age (46%), neonatal hypoglycemia (41.1%), respiratory distress syndrome (7.7%), and jaundice (29.3%).

Conclusions

Diabetes-in-pregnancy rates have more than doubled over the last decade, driven primarily by increases in GDM and T2DM. These trends may have significant implications for the future health of mothers and children in Alberta.

目标本研究旨在采用一种新验证的算法来识别患有 1 型糖尿病 (T1DM)、2 型糖尿病 (T2DM) 和妊娠糖尿病 (GDM) 的孕妇,并确定过去十年中患病率的时间趋势。我们还比较了有糖尿病(DM)和无糖尿病(DM)妊娠的产科和新生儿结局。方法在艾伯塔省 2005 年至 2018 年间的活产妇女中,我们计算了 T1DM、T2DM 和 GDM 的年总体发病率,并按种族、城市或农村居住地、物质匮乏评分和产妇年龄进行了分层。结果2005年至2018年期间,GDM率从每1,000例分娩中42.3例增加到101.8例(p<0.0001),T2DM率从每1,000例分娩中2.6例增加到6.4例(p<0.0001),而T1DM每年保持在每1,000例分娩中3.0例(p=0.4301)。华裔和南亚裔妇女的 GDM 和 T2DM 发生率较高,物质匮乏和居住在城市地区的妇女的 GDM 和 T2DM 发生率也较高。患有 T2DM 的妇女年龄较大,原有高血压的比例最高(16%)。相比之下,患有 T1DM 的妇女更年轻,妊娠高血压(12%)、先兆子痫(12%)和剖腹产(62%)的发病率最高。患有 T1DM 的妇女所生子女的胎龄过大(46%)、新生儿低血糖(41.1%)、呼吸窘迫综合征(7.7%)和黄疸(29.3%)发生率最高。这些趋势可能会对艾伯塔省母亲和儿童未来的健康产生重大影响。
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引用次数: 0
Validity of Alternative Claims-based Algorithms for Type 1, Type 2, and Gestational Diabetes in Pregnancy 基于索赔的 1 型、2 型和妊娠期糖尿病替代算法的有效性
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.003
Deliwe P. Ngwezi MBChB, PhD , Anamaria Savu PhD , Roseanne O. Yeung MD, FRCPC, MPH , Sonia Butalia BSc, MD, FRCPC, MSc (Epi) , Padma Kaul PhD

Objective

Our aim in this study was to evaluate the accuracy of alternative algorithms for identifying pre-existing type 1 or 2 diabetes (T1DM or T2DM) and gestational diabetes mellitus (GDM) in pregnant women.

Methods

Data from a clinical registry of pregnant women presenting to an Edmonton diabetes clinic between 2002 and 2009 were linked and administrative health records. Three algorithms for identifying women with T1DM, T2DM, and GDM based on International Classification of Diseases---tenth revision (ICD-10) codes were assessed: delivery hospitalization records (Algorithm #1), outpatient clinics during pregnancy (Algorithm #2), and delivery hospitalization plus outpatient clinics during pregnancy (Algorithm #3). In a subset of women with clinic visits between 2005 and 2009, we examined the performance of an additional Algorithm #4 based on Algorithm #3 plus outpatient clinics in the 2 years before pregnancy. Using the diabetes clinical registry as the “gold standard,” we calculated true positive rates and agreement levels for the algorithms.

Results

The clinical registry included data on 928 pregnancies, of which 90 were T1DM, 89 were T2DM, and 749 were GDM. Algorithm #3 had the highest true positive rate for the detection of T1DM, T2DM, and GDM of 94%, 72%, and 99.9%, respectively, resulting in an overall agreement of 97% in diagnosis between the administrative databases and the clinical registry. Algorithm #4 did not provide much improvement over Algorithm #3 in overall agreement.

Conclusions

An algorithm based on ICD-10 codes in the delivery hospitalization and outpatient clinic records during pregnancy can be used to accurately identify women with T1DM, T2DM, and GDM.

方法 将 2002 年至 2009 年期间在埃德蒙顿糖尿病诊所就诊的孕妇的临床登记数据与行政健康记录联系起来。根据国际疾病分类--第十次修订版(ICD-10)代码评估了三种识别 T1DM、T2DM 和 GDM 妇女的算法:分娩住院记录(算法 #1)、孕期门诊(算法 #2)和分娩住院加孕期门诊(算法 #3)。在 2005 年至 2009 年期间就诊的妇女子集中,我们根据算法 3 加上怀孕前两年的门诊情况,检查了附加算法 4 的性能。以糖尿病临床登记为 "金标准",我们计算了算法的真阳性率和一致性水平。结果临床登记包括 928 例妊娠的数据,其中 90 例为 T1DM,89 例为 T2DM,749 例为 GDM。3号算法对T1DM、T2DM和GDM的检测真阳性率最高,分别为94%、72%和99.9%,因此行政数据库和临床登记的总体诊断一致性为97%。结论基于孕期分娩住院和门诊记录中的 ICD-10 编码的算法可用于准确识别 T1DM、T2DM 和 GDM 妇女。
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引用次数: 0
Dominican Adolescents’ Preferences for Content, Design, and Functionality of a Mobile Application for Type 1 Diabetes Mellitus Self-management 多米尼加青少年对 1 型糖尿病自我管理移动应用程序的内容、设计和功能的偏好
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.006
Arelis Moore PhD, MD, MPH, MEd , Jenny Cepeda MD , Breauna Franklin BS , Gabriela Abreu MD , Shelby Dorth , Ethan Barkley BS

Objective

The purpose of this interdisciplinary study was to determine Dominican adolescents’ preferences for the content, functionality (i.e. food’s glycemic index list, and amount of insulin based on foods’ carbohydrate count), and design of a culturally and linguistically relevant mobile application (app) for type 1 diabetes mellitus (T1DM) self-management. The app would facilitate T1DM self-management education and support by addressing providers’ challenges in monitoring patients’ disease progression and promoting patient adherence to recommended lifestyle changes. Findings inform an app development process that considers the linguistic and cultural values, norms, and structures of people with T1DM and their providers in the Dominican Republic.

Methods

Phone interviews were conducted with 23 adolescents (14 to 18 years of age), using a semistructured questionnaire. The research team conducted the data analysis using NVivo through a deductive and inductive approach.

Results

The findings suggest that, regardless of the context, adolescents with T1DM desire similar features and functionalities in a self-management app. Overall, participants preferred an app with a graphic format that has accessible information, a straightforward design, and instructional videos. Participants also desired that an app provide information and reminders about proper eating and insulin administration timing and be a vehicle to access a social network to foster mutual support and encouragement.

Conclusions

Our study highlights adolescents’ perspectives on components for inclusion in an app for T1DM self-management. Participants' recommendations for the app’s potential usability, contents, and design features will be used to guide the development of a new app to promote engagement and foster better health outcomes.

本跨学科研究旨在确定多米尼加青少年对 1 型糖尿病(T1DM)自我管理移动应用程序(App)的内容、功能(即食物的血糖生成指数列表和基于食物碳水化合物数量的胰岛素用量)和设计的偏好。该应用程序将通过解决医疗服务提供者在监测患者疾病进展和促进患者坚持建议的生活方式改变方面的难题,促进 T1DM 自我管理教育和支持。研究结果为应用程序的开发过程提供了参考,该过程考虑了多米尼加共和国 T1DM 患者及其服务提供者的语言和文化价值观、规范和结构。研究小组通过演绎和归纳的方法使用 NVivo 进行了数据分析。结果研究结果表明,无论在什么情况下,患有 T1DM 的青少年都希望自我管理应用程序具有类似的特点和功能。总体而言,参与者倾向于使用具有可获取信息的图形格式、简单明了的设计和教学视频的应用程序。此外,参与者还希望应用程序能提供有关正确饮食和胰岛素用药时间的信息和提醒,并能成为访问社交网络以促进相互支持和鼓励的工具。参与者就应用程序的潜在可用性、内容和设计特点提出的建议将用于指导新应用程序的开发,以促进参与并取得更好的健康结果。
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引用次数: 0
The Association of Children and Their Educational Attainment With Diabetes-related Complications and Mortality Among Older Adults With Type 2 Diabetes: A Nationwide Cohort Study 子女及其受教育程度与 2 型糖尿病老年患者中糖尿病相关并发症和死亡率的关系:一项全国性队列研究
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.004
Emma Neble Larsen BSc , Mathilde Marie Brünnich Sloth BSc , Jannie Nielsen PhD , Merete Osler MD, PhD , Terese Sara Høj Jørgensen PhD

Objective

Socioeconomic resources and family support have been shown to improve adherence to treatment in people with type 2 diabetes (T2D) and are associated with a lower risk of diabetes-related complications and death. We investigated the associations of having children and their educational level with diabetes-related complications and death among older adults with T2D.

Methods

We included 74,588 adults who were at least 65 years of age at the time of T2D diagnosis over the period from 2000 to 2018 in Denmark and grouped them based on having children (yes [reference]/no), and their children’s highest educational level (low/medium/high [reference]). Multistate models were performed with 3 states: T2D diagnosis, diabetes-related complications, and death. All models were stratified by other chronic diseases at baseline (yes/no).

Results

During follow-up (mean, 5.5 years), 14.6% of the adults developed a complication and 24.8% died with or without complications. Not having children was associated with a higher hazard of death without complications among adults without (hazard ratio [HR], 1.25; 95% confidence interval [CI], 1.17 to 1.33) and with (HR, 1.10; 95% CI, 1.02 to 1.18) other chronic diseases and after complications among adults without other chronic diseases (HR, 1.25; 95% CI, 1.12 to 1.38). Having children with a lower educational level was associated with a higher hazard of complications (HRlow, 1.14; 95% CI, 1.05 to 1.24; HRmedium, 1.11; 95% CI, 1.05 to 1.17), death without complications (HRlow, 1.26; 95% CI, 1.17 to 1.36; HRmedium, 1.07; 95% CI, 1.02 to 1.14), and after complications (HRlow, 1.22; 95% CI, 1.07 to 1.39) among adults without other chronic diseases.

Conclusions

Among adults without other chronic diseases, having no children or having children with lower educational levels was associated with a higher hazard of death. Among these adults, having children with lower educational levels was also associated with a higher hazard of diabetes-related complications.

目的社会经济资源和家庭支持已被证明可提高 2 型糖尿病(T2D)患者的治疗依从性,并与较低的糖尿病相关并发症和死亡风险有关。方法我们纳入了丹麦 2000 年至 2018 年期间确诊 T2D 时年龄至少为 65 岁的 74588 名成年人,并根据是否有子女(有 [参考] / 无)及其子女的最高教育水平(低/中/高 [参考])对他们进行了分组。多态模型包含 3 个状态:T2D诊断、糖尿病相关并发症和死亡。结果在随访期间(平均 5.5 年),14.6% 的成年人出现并发症,24.8% 的成年人在出现或未出现并发症的情况下死亡。在没有其他慢性疾病(危险比[HR],1.25;95% 置信区间[CI],1.17 至 1.33)和患有其他慢性疾病(危险比[HR],1.10;95% 置信区间[CI],1.02 至 1.18)的成年人中,没有子女与无并发症死亡的较高风险相关,而在没有其他慢性疾病的成年人中,有子女与并发症后死亡的较高风险相关(危险比[HR],1.25;95% 置信区间[CI],1.12 至 1.38)。子女受教育水平较低与较高的并发症(HRlow,1.14;95% CI,1.05 至 1.24;HRmedium,1.11;95% CI,1.05 至 1.17)、无并发症死亡(HRlow,1.26;95% CI,1.17 至 1.36;HRmedium,1.07;95% CI,1.02 至 1.结论在没有其他慢性疾病的成年人中,没有子女或子女受教育程度较低与较高的死亡风险有关。在这些成年人中,子女受教育水平较低的人患糖尿病相关并发症的风险也较高。
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引用次数: 0
Socioeconomic Disparities in Glycemic Management in Children and Youth With Type 1 Diabetes: A Retrospective Cohort Study 1 型糖尿病儿童和青少年血糖管理中的社会经济差异:回顾性队列研究
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.005
Suzanne Simba MSc , Julia E. Von Oettingen MD, PhD, MMSc , Elham Rahme PhD , Jennifer M. Ladd MD, MSc , Meranda Nakhla MD, MSc , Patricia Li MD, MSc

Objective

In Canada, few studies have addressed health inequalities in type 1 diabetes (T1D) outcomes. In this study, we examined the relationship between socioeconomic status (SES) and glycemic management in children with T1D and determine whether technology use (insulin pumps or continuous glucose monitoring [CGM]), diabetes-related physician visits, and depressive symptoms modified the association.

Methods

This work was a retrospective cohort study using the Montréal Children’s Hospital Pediatric Diabetes Database of children 0 to 18 years old, diagnosed with T1D for ≥1 year, and with a hospital visit between November 2019 and October 2020. Main exposure was SES measured by the Material and Social Deprivation Index (least, moderately, or most deprived). We determined the association between SES and mean glycated hemoglobin (A1C; main outcome) in the year after the index visit using multivariable linear regression, adjusting for age, sex, diabetes duration, technology use, diabetes-related physician visits, and depressive symptoms (subgroup). We examined interaction terms for technology use, diabetes-related physician visits, and depressive symptoms.

Results

The study cohort included 306 children (mean age 13.6 years, mean A1C 8.5%). Children in the most-deprived compared with least-deprived quintiles had higher mean A1C; effect modification was significant with CGM only. Children not using CGM in the most-deprived compared with least-deprived quintiles had higher mean A1C (0.52%; 95% confidence interval, 0.14% to 0.86%), whereas the association was not significant for children using CGM.

Conclusions

Lower SES was associated with higher A1C; these disparities were not observed among CGM users. Further research is required to determine strategies to promote CGM access among children of lower SES in the Canadian health-care context.

目标在加拿大,很少有研究涉及 1 型糖尿病(T1D)结果中的健康不平等问题。在这项研究中,我们考察了社会经济地位(SES)与 T1D 儿童血糖管理之间的关系,并确定技术使用(胰岛素泵或连续血糖监测[CGM])、糖尿病相关就诊和抑郁症状是否会改变这种关系。这项工作是一项回顾性队列研究,使用蒙特利尔儿童医院儿科糖尿病数据库,研究对象为 0 至 18 岁、确诊 T1D ≥ 1 年、在 2019 年 11 月至 2020 年 10 月期间到医院就诊的儿童。主要暴露因素是以物质和社会贫困指数(最贫困、中度贫困或最贫困)衡量的SES。我们使用多变量线性回归法确定了 SES 与指数就诊后一年内平均糖化血红蛋白(A1C;主要结果)之间的关系,并对年龄、性别、糖尿病病程、技术使用情况、糖尿病相关就诊情况和抑郁症状(亚组)进行了调整。我们研究了技术使用、糖尿病相关就诊和抑郁症状的交互项。结果研究队列包括 306 名儿童(平均年龄 13.6 岁,平均 A1C 为 8.5%)。与最贫困五分位数的儿童相比,最贫困五分位数的儿童平均 A1C 更高;仅 CGM 的效应修正显著。与最贫困五分位数相比,最贫困五分位数中未使用 CGM 的儿童的平均 A1C 更高(0.52%;95% 置信区间,0.14% 至 0.86%),而使用 CGM 的儿童的相关性不显著。需要进一步研究,以确定在加拿大医疗保健环境中促进较低社会经济地位儿童使用 CGM 的策略。
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引用次数: 0
The Reponic Classification of Insulin 胰岛素的 Reponic 分类
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.05.007
Joshua Moen PhD, MPH
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引用次数: 0
Collaboration and Partnership in a 5-Level Engagement Framework for Diabetic Foot Ulcer Management: A Patient-oriented Scoping Review 糖尿病足溃疡管理五级参与框架中的合作与伙伴关系:以患者为导向的范围界定综述
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.07.002
Virginie Blanchette PhD, DPM , Shweta Todkar PhD , Magali Brousseau-Foley MD, DPM, MSc , Nathalie Rheault MSI , Tom Weisz BA, DCh , Marie-Eve Poitras PhD, RN , Jean-Sébastien Paquette MD, MSc , Marie-Claude Tremblay PhD , Idevânia G. Costa PhD, RN , Maman Joyce Dogba PhD , Anik Giguere PhD , Charles de Mestral MD, PhD , France Légaré MD, PhD

Objective

The management of diabetic foot ulcers (DFUs) is complex, and patient engagement is essential for DFU healing, but it often comes down to the patient's consultation. Therefore, we sought to document patients’ engagement in terms of collaboration and partnership for DFUs in 5 levels (direct care, organizational, policy level, research, and education), as well as strategies for patient engagement using an adapted engagement framework.

Methods

We conducted a scoping review of the literature from inception to April 2022 using the Joanna Briggs Institute method and a patient-oriented approach. We also consulted DFU stakeholders to obtain feedback on the findings. The data were extracted using PROGRESS+ factors for an equity lens. The effects of engagement were described using Bodenheimer’s quadruple aims for value-based care.

Results

Of 4,211 potentially eligible records, 15 studies met our eligibility criteria, including 214 patients involved in engagement initiatives. Most studies were recent (9 of 15 since 2020) and involved patient engagement at the direct medical care level (8 of 15). Self-management (7 of 15) was the principal way to clinically engage the patients. None of the studies sought to define the direct influence of patient engagement on health outcomes.

Conclusions

Very few studies described patients’ characteristics. Engaged patients were typically men from high-income countries, in their 50s, with poorly managed type 2 diabetes. We found little rigorous research of patient engagement at all levels for DFUs. There is an urgent need to improve the reporting of research in this area and to engage a diversity of patients.

目标糖尿病足溃疡(DFU)的治疗非常复杂,患者的参与对 DFU 的愈合至关重要,但这往往取决于患者的咨询。因此,我们试图从 5 个层面(直接护理、组织、政策层面、研究和教育)记录患者在糖尿病足溃疡的合作和伙伴关系方面的参与情况,并使用经过调整的参与框架记录患者参与的策略。方法我们采用乔安娜-布里格斯研究所的方法和以患者为导向的方法,对从开始到 2022 年 4 月的文献进行了范围界定综述。我们还咨询了 DFU 的利益相关者,以获得他们对研究结果的反馈意见。我们使用 PROGRESS+ 因素从公平视角提取数据。结果 在 4211 份可能符合条件的记录中,有 15 项研究符合我们的资格标准,其中包括 214 名参与倡议的患者。大多数研究都是近期进行的(自 2020 年以来的 15 项研究中有 9 项),涉及患者在直接医疗护理层面的参与(15 项研究中有 8 项)。患者参与临床治疗的主要方式是自我管理(15 项研究中的 7 项)。结论很少有研究描述患者的特征。参与研究的患者通常是来自高收入国家、50 多岁、2 型糖尿病控制不佳的男性。我们发现,几乎没有针对各级 DFU 患者参与情况的严谨研究。我们迫切需要改进该领域的研究报告,并让更多患者参与进来。
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引用次数: 1
Moving Beyond One-size-fits-all Solutions: The Importance of Adopting a Health Equity Lens for Addressing the Diabetes Epidemic 超越一刀切的解决方案:采用健康公平视角应对糖尿病流行的重要性。
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.jcjd.2023.10.402
Ghazal S. Fazli MPH, PhD , Lorraine L. Lipscombe MDCM, MSc, FRCPC
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引用次数: 0
SINGLE CENTER EXPERIENCE IN TRANSVENOUS LEAD EXTRACTION AND MANAGEMENT OF TRICUSPID VALVE DISEASE 三尖瓣病经静脉取铅及处理的单中心经验
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-10-25 DOI: 10.1016/j.jcjd.2023.10.079
M. Zaitouni, B. Mondesert, A. Raymond-Paquin, M. Dubuc, B. Thibault, A. Asgar, M. Pellerin, D. Bouchard, P. Garceau
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引用次数: 0
EARLY SUCCESS OF THE TAILORING POST DISCHARGE PROGRAM (TPD) INDICATES FEASIBILITY AND SAFETY OF EARLY DISCHARGE FOR LOW-RISK ACS PATIENTS: A MANITOBA ACS NETWORK INITIATIVE 量身定制出院后计划(TPD)的早期成功表明低风险ACS患者早期出院的可行性和安全性:曼尼托巴ACS网络倡议
IF 2.5 4区 医学 Q2 Medicine Pub Date : 2023-10-25 DOI: 10.1016/j.jcjd.2023.10.036
S. Liu, A. de Haan, D. Kent, L. Avery, T. Nguyen, C. Schaap, J. Cloutier, J. Ducas
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引用次数: 0
期刊
Canadian Journal of Diabetes
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