Pub Date : 2019-12-17DOI: 10.19080/ctoij.2019.15.555911
Dalia Aly Mohamed Aly Abou Taleb
The commonest abnormality is a hematoma, producing a rounded lesion which, in the early stages is , ill defined but which later becomes better defined. Blood clots adjacent to the inner wall of the haematoma may mimic a solid lesion. Associated to this there may be skin thickening, focally increased reflectivity and trabecular distortion, producing quite marked focal attenuation. Eventually a scar results, seen sonographically as a narrow band of attenuation extending down from the skin deeper in the tissue, perhaps persisting trabecular distortion and skin thickening.
{"title":"Post-operative Post Irradiation using Ultrasound Breast Tumor","authors":"Dalia Aly Mohamed Aly Abou Taleb","doi":"10.19080/ctoij.2019.15.555911","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555911","url":null,"abstract":"The commonest abnormality is a hematoma, producing a rounded lesion which, in the early stages is , ill defined but which later becomes better defined. Blood clots adjacent to the inner wall of the haematoma may mimic a solid lesion. Associated to this there may be skin thickening, focally increased reflectivity and trabecular distortion, producing quite marked focal attenuation. Eventually a scar results, seen sonographically as a narrow band of attenuation extending down from the skin deeper in the tissue, perhaps persisting trabecular distortion and skin thickening.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83540512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-12DOI: 10.19080/ctoij.2019.15.555909
S. Demiral
Glomus jugulare tumors (GJTs), also referred to as chemodectomas or paragangliomas are typically benign, highly vascular tumors which are derived from the paraganglionic cells [1-5]. While GJTs arise from the glomus bodies found along the Jacobson nerve (tympanic branch of the glossopharyngeal nerve) or Arnold nerve (auricular branch of the vagus nerve) located within the jugular foramen, glomus tympanicum tumors arise from glomus bodies found along the Jacobson nerve located within the middle ear and cochlear promontory. These rare and highly vascular tumors typically follow an indolent disease course with a low tendency for metastatic spread, however, a wide spectrum of symptoms including pulsatile tinnitus, otalgia, ear fullness, headache, vertigo, dizziness, dysphagia, dysphonia, conductive or sensorineural hearing loss may occur in the setting of mass effect or invasion of nearby critical structures such as the internal carotid artery, jugular bulb, or lower cranial nerves [1-6].
{"title":"Assessment of Target definition based on Multimodality Imaging for Radiosurgical Management of Glomus Jugulare Tumors (gjts)","authors":"S. Demiral","doi":"10.19080/ctoij.2019.15.555909","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555909","url":null,"abstract":"Glomus jugulare tumors (GJTs), also referred to as chemodectomas or paragangliomas are typically benign, highly vascular tumors which are derived from the paraganglionic cells [1-5]. While GJTs arise from the glomus bodies found along the Jacobson nerve (tympanic branch of the glossopharyngeal nerve) or Arnold nerve (auricular branch of the vagus nerve) located within the jugular foramen, glomus tympanicum tumors arise from glomus bodies found along the Jacobson nerve located within the middle ear and cochlear promontory. These rare and highly vascular tumors typically follow an indolent disease course with a low tendency for metastatic spread, however, a wide spectrum of symptoms including pulsatile tinnitus, otalgia, ear fullness, headache, vertigo, dizziness, dysphagia, dysphonia, conductive or sensorineural hearing loss may occur in the setting of mass effect or invasion of nearby critical structures such as the internal carotid artery, jugular bulb, or lower cranial nerves [1-6].","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"159 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73050398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-06DOI: 10.19080/ctoij.2019.15.555908
M. Faisaluddin, P. Iftikhar, Roopam Bansal, Azeem Husain Arast, Javidulla Khan, Azadeh Khayat, A. Jain
Background: Chemotherapy is the foundation for the treatment of various cancers. The advent of targeted treatment and chemotherapy has excited clinicians and scientists to perform clinical trials and studies. With limited medical care resources, bibliometric studies can help guide both researchers and research funding organizations to reallocate and increase the research activity.
{"title":"A Bibliometric Analysis of the Top 100 Most-Cited Articles in Chemotherapy (1910- 2019)","authors":"M. Faisaluddin, P. Iftikhar, Roopam Bansal, Azeem Husain Arast, Javidulla Khan, Azadeh Khayat, A. Jain","doi":"10.19080/ctoij.2019.15.555908","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555908","url":null,"abstract":"Background: Chemotherapy is the foundation for the treatment of various cancers. The advent of targeted treatment and chemotherapy has excited clinicians and scientists to perform clinical trials and studies. With limited medical care resources, bibliometric studies can help guide both researchers and research funding organizations to reallocate and increase the research activity.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88459263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-07DOI: 10.19080/ctoij.2019.15.555907
T. Nageeti
Despite of the use of combined treatment modalities including surgery, radiotherapy, and chemotherapy for the management of high-grade gliomas, the prognosis is still poor with a median survival of 14.6 months following combined treatment [1]. These tumours exhibit an infiltrative growth and it is necessary to control the peripheral infiltrating parts of microscopic tumor, which is usually not visible on imaging, as well as the visible tumor on diagnostic imaging. Therefore, it very important to target both areas with deliver different dose levels trying to spare the critical structures while maximize the dose to the area at risk [2-7]. Intensity modulated radiotherapy (IMRT) is advantageous owing to its better dose distribution and better sparing of normal tissues when compared with traditional 3D radiation treatment [8-11]. Volumetric-modulated arc therapy (VMAT) is a special kind of rotational IMRT [12]. In VMAT during rotation of the gantry, the dose rate and shape Abstract
{"title":"Dosimetric Comparison of Simultaneous Integrated vs. Sequential Boost in Radiotherapy for High Grade Gliomas","authors":"T. Nageeti","doi":"10.19080/ctoij.2019.15.555907","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555907","url":null,"abstract":"Despite of the use of combined treatment modalities including surgery, radiotherapy, and chemotherapy for the management of high-grade gliomas, the prognosis is still poor with a median survival of 14.6 months following combined treatment [1]. These tumours exhibit an infiltrative growth and it is necessary to control the peripheral infiltrating parts of microscopic tumor, which is usually not visible on imaging, as well as the visible tumor on diagnostic imaging. Therefore, it very important to target both areas with deliver different dose levels trying to spare the critical structures while maximize the dose to the area at risk [2-7]. Intensity modulated radiotherapy (IMRT) is advantageous owing to its better dose distribution and better sparing of normal tissues when compared with traditional 3D radiation treatment [8-11]. Volumetric-modulated arc therapy (VMAT) is a special kind of rotational IMRT [12]. In VMAT during rotation of the gantry, the dose rate and shape Abstract","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"284 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74394430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-24DOI: 10.19080/ctoij.2019.15.555906
Stewart D Rose
A plant-based diet is valuable in the primary and secondary prevention of colorectal cancer. Epidemiological studies show a 46%-88% reduced risk of colorectal cancer for those following a plant-based diet. In light of evidence, the World Health Organization International Agency for Research on Cancer (IARC) has classified processed meat as a carcinogen and red meat as a probable carcinogen and has since reaffirmed their decision in light of more recent studies. The pathogenic mechanisms by which processed and red meat can cause colon cancer to have been determined. Several exogenous carcinogens are contained in meat and others are formed as a byproduct of its preparation. Bacterial flora produces several carcinogens endogenously in response to processed and red meat intake. Some of the ways plant foods and their phytonutrients protect against colon cancer are also now understood. The chemoprotective mechanisms of plant foods are through the direct actions of phytochemicals, through the action of fiber, and as a result of the anti-inflammatory environment produced by the colonic flora. While colonoscopy and FIT-DNA tests remain very valuable for secondary prevention, a plant-based diet can provide both primary and secondary prevention of colorectal cancer. Making prevention of colon cancer with a plant-based diet all the more desirable is that it is also a safe and efficacious prophylaxis and treats common comorbidities such as coronary artery disease and type II diabetes.
{"title":"Colorectal Cancer Prevention with a Plant-Based diet","authors":"Stewart D Rose","doi":"10.19080/ctoij.2019.15.555906","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555906","url":null,"abstract":"A plant-based diet is valuable in the primary and secondary prevention of colorectal cancer. Epidemiological studies show a 46%-88% reduced risk of colorectal cancer for those following a plant-based diet. In light of evidence, the World Health Organization International Agency for Research on Cancer (IARC) has classified processed meat as a carcinogen and red meat as a probable carcinogen and has since reaffirmed their decision in light of more recent studies. The pathogenic mechanisms by which processed and red meat can cause colon cancer to have been determined. Several exogenous carcinogens are contained in meat and others are formed as a byproduct of its preparation. Bacterial flora produces several carcinogens endogenously in response to processed and red meat intake. Some of the ways plant foods and their phytonutrients protect against colon cancer are also now understood. The chemoprotective mechanisms of plant foods are through the direct actions of phytochemicals, through the action of fiber, and as a result of the anti-inflammatory environment produced by the colonic flora. While colonoscopy and FIT-DNA tests remain very valuable for secondary prevention, a plant-based diet can provide both primary and secondary prevention of colorectal cancer. Making prevention of colon cancer with a plant-based diet all the more desirable is that it is also a safe and efficacious prophylaxis and treats common comorbidities such as coronary artery disease and type II diabetes.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80199124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-14DOI: 10.19080/ctoij.2019.15.555904
Rawan Khalid Abdulgadir Salih
Gastric cancer is a major health problem worldwide [1,2]. It is now the fifth common cancer and the second leading cause of cancer-related mortality in the world, accounting for more the 10% of the annual cancer deaths globally [3-6]. There is global variation in the incidence of gastric cancers with higher incidence in Southeast Asia specially Korea and Japan and much lower incidence in Africa, Australia and USA. The treatment of gastric cancer depends upon the stage of the disease. One of the commonest staging systems is the American Joint Committee on Cancer (AJCC) gastric cancer staging system AJCC 7th edition, known as the TNM classification [7,8]. In stage I to III, radical surgery in the form of gastrectomy and lymph nodes dissection is the mainstay of the treatment and the aim is cure of the disease. In stage IV, palliative treatment is recommended.
{"title":"Laparoscopy-Assisted Versus Open Gastrectomy for Gastric Cancer: A Comprehensive Systematic Review and Meta-Analysis Based on Randomized Controlled Trials","authors":"Rawan Khalid Abdulgadir Salih","doi":"10.19080/ctoij.2019.15.555904","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555904","url":null,"abstract":"Gastric cancer is a major health problem worldwide [1,2]. It is now the fifth common cancer and the second leading cause of cancer-related mortality in the world, accounting for more the 10% of the annual cancer deaths globally [3-6]. There is global variation in the incidence of gastric cancers with higher incidence in Southeast Asia specially Korea and Japan and much lower incidence in Africa, Australia and USA. The treatment of gastric cancer depends upon the stage of the disease. One of the commonest staging systems is the American Joint Committee on Cancer (AJCC) gastric cancer staging system AJCC 7th edition, known as the TNM classification [7,8]. In stage I to III, radical surgery in the form of gastrectomy and lymph nodes dissection is the mainstay of the treatment and the aim is cure of the disease. In stage IV, palliative treatment is recommended.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85250615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-26DOI: 10.19080/ctoij.2019.15.555903
B. Saberi
Systemic chemotherapy would be challenging to treat brain tumors. Achieving the required concentrations of the chemotherapeutic agents in the brain would be influenced by some factors like the volume of distribution of the agent in the brain parenchyma, the ability of the agent to cross the blood brain barrier and active amount of the drug which can be transported out of the brain. Because of difficulties to reach the specific sites of the brain, drug delivering in systemic chemotherapy for brain tumors would encounter various failures [1]. Also, there are other barriers which influence drug delivering to the brain including blood-cerebrospinal fluid barrier, brain-cerebrospinal fluid barrier and the brain tumor barrier. A monolayer of brain capillary endothelial cells is the main part of the blood brain barrier. The interaction between endothelial and astrocyte cells and the tight junctions between endothelial cells, restrict the brain penetration by the chemotherapeutic agents [2]. Lacking intercellular fenestrations and having low ionic permeability and high electrical resistance in the endothelial cells of brain capillaries, make many of water-soluble agents to be unable to reach the brain.
{"title":"Blood Brain Barrier (Bbb) Role in Delivering the Chemotherapeutic Agents to the Brain in the Treatment of Brain Tumors","authors":"B. Saberi","doi":"10.19080/ctoij.2019.15.555903","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555903","url":null,"abstract":"Systemic chemotherapy would be challenging to treat brain tumors. Achieving the required concentrations of the chemotherapeutic agents in the brain would be influenced by some factors like the volume of distribution of the agent in the brain parenchyma, the ability of the agent to cross the blood brain barrier and active amount of the drug which can be transported out of the brain. Because of difficulties to reach the specific sites of the brain, drug delivering in systemic chemotherapy for brain tumors would encounter various failures [1]. Also, there are other barriers which influence drug delivering to the brain including blood-cerebrospinal fluid barrier, brain-cerebrospinal fluid barrier and the brain tumor barrier. A monolayer of brain capillary endothelial cells is the main part of the blood brain barrier. The interaction between endothelial and astrocyte cells and the tight junctions between endothelial cells, restrict the brain penetration by the chemotherapeutic agents [2]. Lacking intercellular fenestrations and having low ionic permeability and high electrical resistance in the endothelial cells of brain capillaries, make many of water-soluble agents to be unable to reach the brain.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73174786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-03DOI: 10.19080/ctoij.2019.15.555902
N. Hamed
{"title":"Important considerations before Initiation of Ibrutinib Treatment","authors":"N. Hamed","doi":"10.19080/ctoij.2019.15.555902","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555902","url":null,"abstract":"","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72697685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-29DOI: 10.19080/ctoij.2019.15.555901
B. Cristea
Aim: Surgery is the cornerstone in the treatment of gastric cancer and includes conventional open gastrectomy and minimally invasive techniques. Preoperative criteria should be established in order to decrease the rate of conversion to open surgery. To evaluate such criteria, we must focus on computer tomography and upper endoscopy workup. Methods: This is a hospital-based observational retrospective study including 205 patients treated in Fundeni Clinical Institute, during the interval of 2008-2014. The patients were diagnosed with advanced gastric cancer according to endoscopic, computer-tomographic and histopathologic techniques. None of the patients received any neoadjuvant chemotherapy. 144 of patients underwent a curative surgical resection with D2 lymphadenectomy. Results: Minimally invasive surgery was performed on 51 patients; other 26 patients were initially treated by MIS but during operation they were converted to open surgery. Open surgery was performed on 128 patients. Risk factors that led to converting an initially MIS intervention to open intervention comprise: Borrmann 1 (p=0.0275) identified by endoscopy, metastasis (p=0.0416), peritoneal carcinomatosis (p=0.0156) identified by CT scan. On the contrary, endoscopic staging Borrmann 3 proved to be a preventing factor against surgical conversion (p=0.0169). Conclusion: A multivariate analysis of all prospective clinical, endoscopic and tomographic parameters is required to identify the patients with gastric cancer that could benefit more from the robotic platform. Endoscopic parameters as the distance from cardia, distance to pylorus, the invasion of more than one gastric wall, the invasion of both vertical and horizontal portion, might constitute criteria for the selection of surgical methods.
{"title":"How to Decide about Robotic Surgery in Patients with Locally Advanced Gastric Cancer?","authors":"B. Cristea","doi":"10.19080/ctoij.2019.15.555901","DOIUrl":"https://doi.org/10.19080/ctoij.2019.15.555901","url":null,"abstract":"Aim: Surgery is the cornerstone in the treatment of gastric cancer and includes conventional open gastrectomy and minimally invasive techniques. Preoperative criteria should be established in order to decrease the rate of conversion to open surgery. To evaluate such criteria, we must focus on computer tomography and upper endoscopy workup. Methods: This is a hospital-based observational retrospective study including 205 patients treated in Fundeni Clinical Institute, during the interval of 2008-2014. The patients were diagnosed with advanced gastric cancer according to endoscopic, computer-tomographic and histopathologic techniques. None of the patients received any neoadjuvant chemotherapy. 144 of patients underwent a curative surgical resection with D2 lymphadenectomy. Results: Minimally invasive surgery was performed on 51 patients; other 26 patients were initially treated by MIS but during operation they were converted to open surgery. Open surgery was performed on 128 patients. Risk factors that led to converting an initially MIS intervention to open intervention comprise: Borrmann 1 (p=0.0275) identified by endoscopy, metastasis (p=0.0416), peritoneal carcinomatosis (p=0.0156) identified by CT scan. On the contrary, endoscopic staging Borrmann 3 proved to be a preventing factor against surgical conversion (p=0.0169). Conclusion: A multivariate analysis of all prospective clinical, endoscopic and tomographic parameters is required to identify the patients with gastric cancer that could benefit more from the robotic platform. Endoscopic parameters as the distance from cardia, distance to pylorus, the invasion of more than one gastric wall, the invasion of both vertical and horizontal portion, might constitute criteria for the selection of surgical methods.","PeriodicalId":9575,"journal":{"name":"Cancer Therapy & Oncology International Journal","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90838062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：