Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

英文中文

Systematic review and meta-analysis of Densiron-68 anatomic outcomes and complications in the surgical management of retinal detachment 视网膜脱离手术治疗中Densiron-68解剖结果和并发症的系统回顾和荟萃分析。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.05.018

Grace S. Yin , Alexa Fine , Marko M. Popovic , Peter J. Kertes , Rajeev H. Muni

Objective

To summarize the anatomical reattachment rates, functional outcomes, and complications associated with Densiron-68 in retinal detachment (RD) surgery.

Methods

Following a systematic literature search, primary studies evaluating outcomes associated with Densiron-68 in adult RD surgery between January 2000 and May 2022 were included. Exclusion criteria included secondary studies, non-English language, and those in pediatric populations. The primary endpoints of interest were anatomical reattachment rate, and reported complications associated with Densiron-68.

Results

Twenty-eight studies (927 eyes) were included. Mean follow-up time was 41.9 weeks (IQR: 32.4–52.0 weeks). The weighted mean preoperative and postoperative BCVA was 1.38 ± 0.64 logMAR (20/500 Snellen) and 0.86 ± 0.55 logMAR (20/150 Snellen), respectively (p < 0.001). Anatomical reattachment rate after a single surgery was 72.5% overall (n = 672 eyes), with most redetachments occurring while Densiron-68 was in situ (46%; n = 81/255 eyes). Postoperatively, 29 complications were identified. The three most common were raised intraocular pressure (IOP) (n = 251 eyes; 27.1%), intraocular inflammation (n = 182 eyes; 19.6%), and emulsification (n = 160 eyes; 17.3%). Densiron-68 was significantly associated with an increased risk of elevated intraocular pressure postoperatively than traditional silicone oil (RR: 1.83 95% CI: 1.25–2.67; p = 0.001). The overall GRADE certainty of evidence for included studies was determined to be low due to the risk of bias, moderate imprecision in results due to wide confidence intervals, small studies, and few events within comparative studies, and moderate to high heterogeneity impacting consistency of evidence.

Conclusions

Densiron-68 is a heavy silicone oil with clinical utility in retinal detachment surgery that has good primary anatomical reattachment rates and overall improvement in BCVA preoperatively to postoperatively. The authors highlight the anatomical and functional outcomes of Densiron-68 and the reported range of complications associated with its use, of which the majority were reversible or treatable with appropriate therapies.

目的：总结Densiron-68在视网膜脱离（RD）手术中的解剖再附着率、功能结局和并发症。方法：通过系统的文献检索，纳入2000年1月至2022年5月成人RD手术中评估Densiron-68相关结果的初步研究。排除标准包括次要研究、非英语语言研究和儿科人群研究。主要研究终点为解剖再附着率和Densiron-68相关并发症。结果：纳入28项研究（927只眼）。平均随访时间41.9周（IQR: 32.4-52.0周）。加权平均术前、术后BCVA分别为1.38±0.64 logMAR （20/500 Snellen）和0.86±0.55 logMAR (20/150 Snellen) （p < 0.001）。单次手术后解剖再附着率为72.5% （n = 672只眼），大多数再附着发生在Densiron-68原位时(46%；n = 81/255眼)。术后共发现29例并发症。最常见的三种是眼压升高(n = 251眼；27.1%)，眼内炎症(n = 182眼；19.6%)，乳化术(n = 160眼；17.3%)。与传统硅油相比，Densiron-68与术后眼压升高的风险显著相关(RR: 1.83 95% CI: 1.25-2.67； = 0.001页)。由于存在偏倚风险，纳入研究的证据总体GRADE确定性为低；由于置信区间较宽，研究规模较小，比较研究中事件较少，结果存在中度不精确；中等至高度异质性影响证据的一致性。结论：Densiron-68是一种重质硅油，在视网膜脱离手术中具有临床应用价值，具有良好的原发性解剖再附着率和术前至术后BCVA的整体改善。作者强调了Densiron-68的解剖和功能结果，以及报道的与使用相关的并发症范围，其中大多数是可逆的或通过适当的治疗可以治疗的。

{"title":"Systematic review and meta-analysis of Densiron-68 anatomic outcomes and complications in the surgical management of retinal detachment","authors":"Grace S. Yin , Alexa Fine , Marko M. Popovic , Peter J. Kertes , Rajeev H. Muni","doi":"10.1016/j.jcjo.2025.05.018","DOIUrl":"10.1016/j.jcjo.2025.05.018","url":null,"abstract":"<div><h3>Objective</h3><div>To summarize the anatomical reattachment rates, functional outcomes, and complications associated with Densiron-68 in retinal detachment (RD) surgery.</div></div><div><h3>Methods</h3><div>Following a systematic literature search, primary studies evaluating outcomes associated with Densiron-68 in adult RD surgery between January 2000 and May 2022 were included. Exclusion criteria included secondary studies, non-English language, and those in pediatric populations. The primary endpoints of interest were anatomical reattachment rate, and reported complications associated with Densiron-68.</div></div><div><h3>Results</h3><div>Twenty-eight studies (927 eyes) were included. Mean follow-up time was 41.9 weeks (IQR: 32.4–52.0 weeks). The weighted mean preoperative and postoperative BCVA was 1.38 <strong>±</strong> 0.64 logMAR (20/500 Snellen) and 0.86 <strong>±</strong> 0.55 logMAR (20/150 Snellen), respectively (<em>p</em> < 0.001). Anatomical reattachment rate after a single surgery was 72.5% overall (n = 672 eyes), with most redetachments occurring while Densiron-68 was in situ (46%; n = 81/255 eyes). Postoperatively, 29 complications were identified. The three most common were raised intraocular pressure (IOP) (n = 251 eyes; 27.1%), intraocular inflammation (n = 182 eyes; 19.6%), and emulsification (n = 160 eyes; 17.3%). Densiron-68 was significantly associated with an increased risk of elevated intraocular pressure postoperatively than traditional silicone oil (RR: 1.83 95% CI: 1.25–2.67; <em>p</em> = 0.001). The overall GRADE certainty of evidence for included studies was determined to be low due to the risk of bias, moderate imprecision in results due to wide confidence intervals, small studies, and few events within comparative studies, and moderate to high heterogeneity impacting consistency of evidence.</div></div><div><h3>Conclusions</h3><div>Densiron-68 is a heavy silicone oil with clinical utility in retinal detachment surgery that has good primary anatomical reattachment rates and overall improvement in BCVA preoperatively to postoperatively. The authors highlight the anatomical and functional outcomes of Densiron-68 and the reported range of complications associated with its use, of which the majority were reversible or treatable with appropriate therapies.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 6","pages":"Pages e821-e835"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geographic atrophy in Korean patients with dry age-related macular degeneration: incidence, phenotypes, and progression 韩国干性年龄相关性黄斑变性患者的地理萎缩：发病率、表型和进展。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.05.026

Ye Eun Han , Hoon Il Choi , Junyeop Lee , Yoon Jeon Kim , Joo Yong Lee , Srinivas R. Sadda , Young Hee Yoon

Objective

To evaluate the characteristics of geographic atrophy (GA) in Korean patients, including incidence, phenotypes, progression patterns, and factors associated with progression rates.

Design

Retrospective longitudinal cohort study.

Participants

Korean patients with intermediate and advanced (prevalent GA) dry AMD, followed for ≥3 years.

Methods

GA incidence was defined as the percentage of new GA emerging from the intermediate dry AMD group during the follow-up. Baseline phenotypes were evaluated in the prevalent GA group at the initial visit using fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence (FAF). Progression patterns were assessed by growth rates (mm²/year and mm/year using square-root treansformation [SQRT]), and the centripetal growth direction (foveal involvement of extrafoveal lesions). Linear regression was used to identify factors associated with progression rates.

Results

In intermediate dry AMD group (395 eyes/241 patients), GA incidence was 6.8%, while wet conversion was 14.4%, during 60.5 ± 13.5 months. In prevalent GA group (70 eyes/46 patients), the mean lesion size was 7.2 ± 7.1 mm² (2.4 ± 1.3 mm [SQRT]), with bilateral involvement in 68.6%, banded/diffuse FAF patterns in 81.4%, extrafoveal and multifocal locations in 51.4% and 84.3%, and drusen and reticular pseudodrusen in 87.1% and 34.3%. The progression rate was 2.0 ± 1.3 mm²/year (0.3 ± 0.2 mm/year [SQRT]), with 69.4% exhibiting centripetal direction during 61.2 ± 14.5 months. Large lesion size, banded/diffuse FAF patterns, and extrafoveal locations were positively associated with progression rates (p = 0.006, 0.007, and 0.008).

Conclusions

The 5-year incidence of GA in Korean patients with intermediate dry AMD was 6.8%, approximately half of the rate of wet conversion. The mean GA progression rate was 2.0 mm²/year (0.3 mm/year [SQRT]). Risk factors for fast progression were banded/diffuse FAF patterns, extrafoveal locations, and large lesion size.

目的：评估韩国患者的地理萎缩（GA）特征，包括发病率、表型、进展模式和与进展率相关的因素。设计：回顾性纵向队列研究。参与者：韩国中晚期（普遍GA）干性AMD患者，随访≥3年。方法：GA发生率定义为中度干性AMD组随访期间新发GA的百分比。在首次就诊时，使用眼底摄影、光谱域光学相干断层扫描和眼底自体荧光（FAF）评估普遍GA组的基线表型。通过生长速率（毫米/年，平方根转变）和向心生长方向（中央凹累及中央凹外病变）来评估进展模式。线性回归用于确定与进展率相关的因素。结果：中度干性AMD组（395眼/241例）GA发生率为6.8%，湿性AMD发生率为14.4%，时间为60.5±13.5个月。常见GA组（70眼/46例）平均病变大小为7.2±7.1 mm2，双侧受累占68.6%，带状/弥漫性FAF占81.4%，中央凹外和多灶分别占51.4%和84.3%，结节和网状假性结节分别占87.1%和34.3%。进展率为0.3±0.2 mm/年，其中69.4%在44.3±23.0个月内表现为向心方向。大的病灶大小、带状/弥漫性FAF模式和中央凹外位置与进展率呈正相关（p = 0.008、0.006和0.007）。结论：韩国中度干性AMD患者5年GA发生率为6.8%，约为湿性AMD患者5年GA发生率的一半。GA进展率为0.3±0.2 mm/年。快速进展的危险因素是大的病变，带状/弥漫性FAF模式，和中央凹外的位置。

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引用次数: 0

Renal cell carcinoma metastasis to an eyelid: systemic cancer history imperative when assessing new eyelid lesions 肾细胞癌转移到眼睑：当评估新的眼睑病变时，系统性癌症病史是必要的。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.06.024

Sina Tangestanipour , Sara Jessica Brade , Lisa Jagan , Vladimir Kratky

引用次数: 0

Anti-MOG optic neuritis following SARS-CoV-2 vaccination: a case report SARS-CoV-2疫苗接种后抗mog视神经炎1例报告

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.06.018

Logan C. Barr , Ryan H. Kirkpatrick , Jacob Rullo

引用次数: 0

Pigmented paravenous chorioretinal atrophy 色素静脉旁绒毛膜视网膜萎缩。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.07.004

Sara Fard, Melis Kabaalioglu Guner, Wei Wang

引用次数: 0

One-week response of retinal hemangioblastomas to oral belzutifan 视网膜血管母细胞瘤对口服贝祖替芬一周的反应。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.08.014

Taweevat Attaseth, Yu-Bai Chou, Carol L. Shields

引用次数: 0

Exploring the gender gap in Canadian ophthalmology applicants: a mixed methods study. 探讨加拿大眼科申请者的性别差异：一项混合方法研究。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-11-29 DOI: 10.1016/j.jcjo.2025.11.011

Mostafa Bondok, Mohamed S Bondok, Michael Knafo, Christine Law, Nawaaz Nathoo, Lars J Grimm, Anuradha Mishra

Purpose: To examine and compare medical students' perceptions of ophthalmology as a career, with a focus on women and under-represented students.

Study design: Phase 1 of a multi-institutional, explanatory sequential mixed-methods study.

Methods: Medical students from 4 geographically representative Canadian institutions with varying levels of ophthalmology exposure completed a 17-item survey assessing perceptions, barriers, and facilitators to pursuing ophthalmology. Quantitative data were analyzed using nonparametric tests and ordinal logistic regression to assess associations between both demographics and context-specific factors and survey responses. Open-ended qualitative responses were analyzed thematically using Braun and Clarke's framework.

Results: A total of 314 students participated, including 213 (67.8%) women, 125 (39.8%) visible minorities, and 73 (23.3%) Canadian immigrants. Negative perceptions of pursuing ophthalmology increased during medical school, with 29.9% of students expressing a negative view at the start of medical school compared to 45.5% at the time of the survey-a 52.1% relative increase (p = 0.007). Only 30.9% viewed the field as racially diverse, and 26.8% as gender balanced. Analysis of the qualitative responses showed that barriers to pursuing ophthalmology included intense competition, limited early exposure, lack of mentorship, perceived exclusivity based on personal connections, high research expectations, and difficulties with parallel planning.

Conclusions: Increased early exposure, improved mentorship opportunities, and promoting diversity may support greater gender and racial representation in ophthalmology.

目的：检查和比较医学生对眼科作为职业的看法，重点关注女性和代表性不足的学生。研究设计：一项多机构、解释性顺序混合方法研究的第一阶段。方法：来自加拿大4个具有地理代表性的机构的医学生，他们接受过不同程度的眼科教育，完成了一项17项调查，评估了他们对眼科的认知、障碍和促进因素。使用非参数检验和有序逻辑回归分析定量数据，以评估人口统计学和特定环境因素与调查反应之间的关联。使用Braun和Clarke的框架对开放式定性回答进行主题分析。结果：共有314名学生参与，其中女性213人（67.8%），少数族裔125人（39.8%），加拿大移民73人（23.3%）。对攻读眼科的负面看法在医学院期间有所增加，29.9%的学生在医学院开始时表达了负面看法，而调查时为45.5%，相对增加了52.1% （p = 0.007）。只有30.9%的人认为该领域种族多元化，26.8%的人认为性别平衡。对定性反应的分析表明，从事眼科研究的障碍包括激烈的竞争、有限的早期接触、缺乏指导、基于个人关系的排他性、高研究期望以及并行规划的困难。结论：增加早期接触，改善指导机会，促进多样性可能会支持眼科中更多的性别和种族代表性。

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引用次数: 0

Localized conjunctival amyloidosis masquerading as chronic papillary conjunctivitis. 局部结膜淀粉样变伪装成慢性乳头状结膜炎。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-11-29 DOI: 10.1016/j.jcjo.2025.11.010

Grace Lin, Alexandre Odashiro, Marie-Claude Robert

引用次数: 0

Risk of oculomotor and trochlear nerve palsies following COVID-19 vaccination. COVID-19疫苗接种后动眼神经和滑车神经麻痹的风险。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-11-27 DOI: 10.1016/j.jcjo.2025.10.004

Alexander Kwok, Muhammad Z Chauhan, Qais Dihan, Omar Solyman, Paul H Phillips, Abdelrahman M Elhusseiny

Objective: To investigate the prevalence and risk of new-onset oculomotor and trochlear nerve palsy following coronavirus disease (COVID-19) vaccination.

Design: This retrospective, cross-sectional study analyzed data from the COVID-19 Research Network of TriNetX.

Participants: We identified patients who received COVID-19, influenza, or tetanus, diphtheria, and pertussis (Tdap) vaccinations or who had COVID-19 infection.

Methods: We calculated the relative risk (RR) across groups. We performed propensity score matching to balance the cohorts. Significance tests were paired and 2-sided, with 95% confidence intervals (CI) and p < 0.05. The primary outcome was new oculomotor or trochlear nerve palsies within 21 days of vaccination.

Results: Among >6,500,000 vaccinated patients (mean age: 46.7 ± 21.4 years), 11 and 15 developed oculomotor and trochlear nerve palsy, respectively, within 21 days of the first COVID-19 dose. The RR for oculomotor palsy after the first COVID-19 dose was similar to influenza (RR, 1.00, 95% CI, 0.416 - 2.40; p = 0.99), Tdap (RR, 0.99, 95% CI, 0.41 - 2.40; p = 0.99), and second COVID-19 dose vaccinations (RR, 1.00, 95% CI, 0.41- 2.40; p = 0.99), but lower than COVID-19 infection (RR, 0.16, 95% CI, 0.08 - 0.33; p < 0.0001). Trochlear nerve palsy risk was comparable across all groups.

Conclusions: The risk of oculomotor and trochlear nerve palsies after COVID-19 vaccination is similar to other vaccines. The risk of oculomotor nerve palsy is lower after vaccination than after COVID-19 infection. No evidence suggests a causal relationship between COVID-19 vaccination and these cranial neuropathies.

目的：了解新型冠状病毒肺炎（COVID-19）疫苗接种后新发动眼神经和滑车神经麻痹的患病率及风险。设计：本回顾性横断面研究分析了TriNetX COVID-19研究网络的数据。参与者：我们使用通用程序技术代码确定了接受COVID-19、流感或破伤风、白喉和百日咳（Tdap）疫苗接种或COVID-19感染的患者。方法：计算各组间的相对危险度（RR）。我们进行倾向评分匹配来平衡队列。显著性检验采用配对和双侧检验，置信区间为95%，p < 0.05。主要结局是接种疫苗后21天内出现新的动眼神经或滑车神经麻痹。结果：在bb650万例接种疫苗的患者中（平均年龄46.7±21.4岁），在首次接种后21天内分别有11例和15例发生动眼神经麻痹和滑车神经麻痹。第一次接种COVID-19疫苗后动眼性麻痹的RR与流感（RR, 1.00, 95%可信区间[CI]， 0.416 ~ 2.40; p = 0.99）、Tdap （RR, 0.99, 95% CI, 0.41 ~ 2.40; p = 0.99）和第二次接种COVID-19疫苗（RR, 1.00, 95% CI, 0.41 ~ 2.40; p = 0.999）相似，但低于COVID-19感染（RR, 0.169, 95% CI, 0.08 ~ 0.33; p < 0.0001）。滑车神经麻痹的风险在所有组间具有可比性。结论：COVID-19疫苗接种后发生动眼神经麻痹和滑车神经麻痹的风险与其他疫苗相似。接种疫苗后发生动眼神经麻痹的风险低于感染COVID-19后。没有证据表明COVID-19疫苗接种与这些颅神经病变之间存在因果关系。

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引用次数: 0

Combined consecutive bilateral occlusive vasculitis and CMV retinitis in immunosuppression with JAK Inhibitor. JAK抑制剂免疫抑制合并双侧连续闭塞性血管炎和巨细胞病毒性视网膜炎1例。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-11-27 DOI: 10.1016/j.jcjo.2025.10.005

Yacine Zaffour, Christof Hänsli, Evangelina Esposito, Sébastien Olivier, Marie-Josée Aubin

引用次数: 0

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