Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

英文中文

Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database 从FDA不良事件数据库中调查药物性视神经发育不全和视隔发育不良。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.05.005

Ayesh Ali , Jamal O. Azhari , Ryan Gise , Omar Solyman , Paul H. Phillips , Abdelrahman M. Elhusseiny

Objective

To identify potential teratogenic medication associated with optic nerve hypoplasia (ONH) and/or septo-optic dysplasia (SOD), by screening the Food and Drug Administration Adverse Events Reporting System (FAERS) database.

Design

Retrospective pharmacovigilance study using disproportionality signal detection methods.

Participants

Adverse event reports submitted to FAERS between Q1 2004 and Q3 2024. Reports were included if ONH or SOD was listed as an adverse event and drug exposure occurred in utero.

Methods

A qualitative assessment evaluated patient demographics, and a disproportionality analysis covered pharmacovigilance signal detection and drug-event reporting frequencies. Pharmacovigilance algorithms that were applied to determine the statistical significance of signals included the proportional reporting ratio (PRR), chi-squared with Yates’ correction (χ²), reporting odds ratio (ROR), empirical Bayes geometric mean (EBGM), and information component (IC).

Results

A total of 103 adverse event reports for ONH and/or SOD were identified. The 75 cases reporting prenatal medication exposure were included. Twenty-three reports were of male patients, 13 reports of female patients, and 39 of unspecified gender. Thirty drugs were implicated as primary suspect drugs. Diazepam was the most reported primary suspect medication (n = 15; 20%) followed by methadone and citalopram (n = 8; 11%). The disproportionality analysis showed a positive signal with one medication: diazepam (n = 15; PRR = 82.24; χ² = 1008.66, ROR 95% CI: 102.55 [56.75–185.33], EBGM [EBGM05]: 48.45 [28.16], IC [IC05]: 4.46 [3.67]).

Conclusions

A possible association was found between prenatal diazepam exposure and ONH/SOD. Further investigation is required to confirm this relationship and drug safety profiles.

目的：通过筛选美国食品和药物管理局不良事件报告系统（FAERS）数据库，确定与视神经发育不全（ONH）和/或视隔-视神经发育不良（SOD）相关的潜在致畸药物。设计：采用歧化信号检测方法进行回顾性药物警戒研究。参与者：2004年第一季度至2024年第三季度期间向FAERS提交的不良事件报告。如果ONH或SOD被列为不良事件，并且药物暴露发生在子宫内，则纳入报告。方法：定性评估患者人口统计学特征，歧化分析包括药物警戒信号检测和药物事件报告频率。用于确定信号统计学显著性的药物警戒算法包括比例报告比（PRR）、叶茨校正卡方（χ2）、报告优势比（ROR）、经验贝叶斯几何平均（EBGM）和信息分量（IC）。结果：共发现103例ONH和/或SOD不良事件报告。包括75例报告产前药物暴露的病例。23例为男性患者，13例为女性患者，39例性别不详。30种毒品被认为是主要的嫌疑毒品。地西泮是报告最多的主要可疑药物(n = 15；20%)，其次是美沙酮和西酞普兰(n = 8；11%)。歧化分析显示一种药物：地西泮(n = 15；PRR = 82.24;1008.66χ2 = ROR 95% CI: 102.55 (56.75 - -185.33), EBGM [EBGM05]: 48.45 (28.16), IC [IC05]: 4.46[3.67])。结论：产前地西泮暴露与ONH/SOD之间可能存在关联。需要进一步的调查来证实这种关系和药物安全性概况。

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引用次数: 0

Flieringa scleral fixation ring-assisted Descemet membrane endothelial keratoplasty in complex eyes 巩膜固定环辅助下角膜内皮移植术在复杂眼中的应用。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.07.003

Gabriele Gallo Afflitto , Shafi Balal , Francesco Aiello , Vincenzo Maurino

引用次数: 0

Relapse of B-cell acute lymphoblastic leukemia revealed by multiple ocular locations 多眼部位显示的b细胞急性淋巴细胞白血病复发。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.06.012

Lauriana Solecki , Anne Sophie Gauthier , Arnaud Sauer

引用次数: 0

Anterior chamber paracentesis for increased intraocular pressure with intravitreal injections: systematic review and meta-analysis 前房穿刺术治疗玻璃体内注射升高眼压：系统回顾和荟萃分析。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.06.003

Michele Zaman , Sarah Alowedi , Sanjay Sharma

Objective

Intravitreal injections (IVIs) can cause a transient asymptomatic spike in intraocular pressure (IOP), which may cause irreversible damage to the patient’s optic nerve. Anterior chamber paracentesis (ACP) is a well-established method to lower IOP. We aim to systematically review the literature, assessing the safety and efficacy of ACP for increased IOP with IVI of antivascular endothelial growth factor medications.

Methods

The following databases were used: MEDLINE, EMBASE, and CINAHL. Articles were included if they had human participants and discussed the use of ACP for increased IOP during IVIs. Key terms searched were anterior chamber paracentesis, intravitreal injections, and intraocular pressure.

Results

Our search captured 236 articles, and ultimately 13 studies were included in our review. Six studies were included in our meta-analysis of studies that reported the IOP after 30 minutes post-ACP. Ten included studies reported that ACP is a safe and effective procedure that lowers the IOP of patients during the IVI process. The overall pooled effect size is significant for IOP measurements 30 minutes after ACP is −1.54 with a 95% CI of −2.20 to −0.88 mm Hg, 5 minutes after ACP is −2.37 with a 95% CI of −2.77 to −1.97 mm Hg and 2 minutes after ACP is −5.09 with a 95% CI of −8.48 to −1.70 mm Hg.

Conclusions

In conclusion, performing an ACP is a safe and effective way to reduce the transient spike in IOP after IVIs. However, this procedure is not without the potential for complications.

目的：玻璃体内注射（IVIs）可引起短暂的无症状眼压（IOP）峰值，这可能对患者视神经造成不可逆的损害。前房穿刺术（ACP）是一种行之有效的降低IOP的方法。我们的目的是系统地回顾文献，评估ACP对抗血管内皮生长因子药物IVI升高IOP的安全性和有效性。方法：采用MEDLINE、EMBASE、CINAHL数据库。如果有人类参与者的文章被纳入，并且讨论了在ivi期间使用ACP提高IOP。搜索的关键词是前房穿刺术、玻璃体内注射和眼压。结果：我们检索了236篇文章，最终纳入了13项研究。我们的荟萃分析纳入了6项报告acp后30分钟IOP的研究。10项纳入的研究报告ACP是一种安全有效的手术，可在IVI过程中降低患者的IOP。整个混合效应的大小是重要的眼压测量30分钟后ACP是-1.54,95%可信区间为-2.20至-0.88毫米汞柱,5分钟后ACP是-2.37 95%可信区间为-2.77至-1.97毫米汞柱和2分钟后ACP是-5.09,95%可信区间-8.48到-1.70毫米Hg.Conclusions:总之,执行ACP是安全的和有效的方法来减少新后眼压的瞬时峰值。然而，这种手术并非没有潜在的并发症。

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引用次数: 0

Management of orbital invasion at the caruncle by conjunctival squamous cell carcinoma 结膜鳞状细胞癌侵犯眼眶的治疗。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.08.016

Maria Valeria Da Silva , Normand Laperriere , Hatem Krema

引用次数: 0

Geographic distribution of ophthalmology residency matches: a comparison of pre- and post-virtual interview cycles in Canada. 眼科住院医师匹配的地理分布：加拿大虚拟面试前后周期的比较。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.11.005

Daiana R Pur, Karanvir Gill, Amadeo R Rodriguez

Objective: To determine the impact of virtual interviews on the geographic distribution of matched ophthalmology residency applicants.

Design: A retrospective database review.

Participants: A total of 334 residents commencing ophthalmology training from 2016 to 2024 in 15 Canadian ophthalmology residency programs.

Methods: We gathered publicly available information to compare match outcomes pre-virtual (2016-2019) to virtual interviews (2020-2024). Variables collected included resident names, medical school, and residency program location. Chi-squared tests were conducted to determine whether there was a significant difference in the proportion of applicants matching in the same region, province, and institution as their medical schools in pre-virtual versus virtual interview cycles.

Results: A total of 292 residents (88% completion rate) were identified. Home program matches were similar between the pre-virtual (51.18%) and virtual cohorts (49.70%). Same-province but different-school matches decreased slightly (18.90% pre-virtual vs 16.36% virtual), while same-region but different-province matches (6.30% vs 6.06%) were similar. Conversely, inter-regional matches increased from 23.62% pre-virtual to 27.88% virtual. Chi-squared analysis showed no statistically significant difference in geographic placement between the two groups (χ² = 0.80; p = 0.85).

Conclusions: The transition to virtual interviews in Canadian ophthalmology residency programs did not significantly alter the geographic distribution of matched applicants. While concerns exist that virtual interviews might limit applicants' ability to explore programs outside their home institutions, our findings suggest that other virtual engagement methods, such as online networking, mentorship programs, and social media, may have helped maintain geographic mobility. Future studies could assess whether these trends persist over time and whether similar strategies could enhance applicant program exposure in other specialties.

目的：探讨虚拟面试对匹配眼科住院医师申请人地理分布的影响。设计：回顾性数据库审查。参与者：从2016年到2024年，共有334名住院医师在加拿大15个眼科住院医师项目中接受眼科培训。方法：我们收集公开信息，比较虚拟前（2016-2019）和虚拟面试（2020-2024）的比赛结果。收集的变量包括住院医师姓名、医学院和住院医师项目所在地。进行卡方检验以确定在虚拟前与虚拟面试周期中，申请人在同一地区、省份和机构与其医学院匹配的比例是否存在显着差异。结果：共识别居民292人，完成率88%。家庭节目匹配在虚拟前（51.18%）和虚拟队列（49.70%）之间相似。同省不同学校的比赛略有下降（虚拟前18.90% vs虚拟后16.36%），而同省不同地区的比赛（6.30% vs 6.06%）相似。相反，区域间的匹配从虚拟前的23.62%增加到虚拟后的27.88%。卡方分析显示两组患者地理位置差异无统计学意义（χ² = 0.80;p = 0.85）。结论：加拿大眼科住院医师项目向虚拟面试的过渡并没有显著改变匹配申请人的地理分布。尽管有人担心虚拟面试可能会限制申请人在本国院校之外探索项目的能力，但我们的研究结果表明，其他虚拟参与方法，如在线网络、指导项目和社交媒体，可能有助于保持地域流动性。未来的研究可以评估这些趋势是否会持续一段时间，以及类似的策略是否可以提高申请人在其他专业的项目曝光率。

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引用次数: 0

Short-term effects of tetracycline use in patients with diabetic retinopathy 四环素在糖尿病视网膜病变患者中的短期疗效。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.04.009

Ahmed M. Alshaikhsalama , Amer F. Alsoudi , Karen M. Wai , Euna Koo , Prithvi Mruthyunjaya , Christina Y. Weng , Ehsan Rahimy

Objective

To investigate the association between tetracycline use and the development of short-term vision threatening complications (VTC) among patients with diabetic retinopathy (DR).

Methods

Using a deidentified database, 4 596 patients with severe nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) associated with tetracycline use versus 87,974 patients with NPDR or PDR but no tetracycline use, respectively, were included before propensity score matching (PSM). After PSM, 4 576 patients in each cohort were analyzed. Incidence of developing VTC, including diabetic macular edema (DME), vitreous hemorrhage (VH), tractional retinal detachment (TRD), neovascular glaucoma (NVG), and subsequent need for ocular interventions including intravitreal anti-vascular endothelial growth factor (VEGF) injections, panretinal photocoagulation (PRP), or pars plana vitrectomy (PPV).

Results

Patients with DR and repeated tetracycline use had a reduced risk of developing DME (RR: 0.45, 95% CI: 0.28–0.72; p = 0.009) and VH (RR: 0.37, 95% CI: 0.20–0.69; p = 0.001) compared to the tetracycline-naive cohort at 6 months and 1 year. Further, there was a reduced risk of subsequent need for anti-VEGF (RR: 0.25, 95% CI: 0.13–0.47; p = 0.003) and PRP (RR: 0.40, 95% CI: 0.19–0.84; p = 0.012) in the tetracycline cohort compared to the tetracycline-naive group at 6 months and 1 year. There were no significant differences in the development of NVG, TRD, or the requirement for PPV between both cohorts.

Conclusions

Repeated tetracycline use was associated with a potentially reduced short-term risk of developing DME, VH, and needing subsequent anti-VEGF or PRP therapy versus tetracycline naive patients.

目的：探讨四环素与糖尿病视网膜病变（DR）患者短期视力威胁并发症（VTC）发生的关系。方法：使用一个未识别的数据库，在倾向评分匹配（PSM）前分别纳入4596例与四环素使用相关的严重非增殖性糖尿病视网膜病变（NPDR）或增殖性糖尿病视网膜病变（PDR）患者和87974例NPDR或PDR但未使用四环素的患者。PSM后，每个队列中有4576例患者进行分析。发生VTC的发生率，包括糖尿病性黄斑水肿（DME）、玻璃体出血（VH）、牵拉性视网膜脱离（TRD）、新生血管性青光眼（NVG），以及随后需要进行眼部干预，包括玻璃体内注射抗血管内皮生长因子（VEGF）、全视网膜光凝（PRP）或玻璃体平面部切除术（PPV）。结果：DR和反复使用四环素的患者发生DME的风险降低(RR: 0.45, 95% CI: 0.28-0.72；p = 0.009)和VH (RR: 0.37, 95% CI: 0.20-0.69；P = 0.001)，与未使用四环素的队列在6个月和1年时相比。此外，随后需要抗vegf的风险降低(RR: 0.25, 95% CI: 0.13-0.47；p = 0.003)和PRP (RR: 0.40, 95% CI: 0.19-0.84；P = 0.012)与四环素初始组在6个月和1年的比较。在两组患者中，NVG、TRD的发展或PPV的需求没有显著差异。结论：与未接受四环素治疗的患者相比，反复使用四环素可潜在降低发生DME、VH的短期风险，并需要后续抗vegf或PRP治疗。

{"title":"Short-term effects of tetracycline use in patients with diabetic retinopathy","authors":"Ahmed M. Alshaikhsalama , Amer F. Alsoudi , Karen M. Wai , Euna Koo , Prithvi Mruthyunjaya , Christina Y. Weng , Ehsan Rahimy","doi":"10.1016/j.jcjo.2025.04.009","DOIUrl":"10.1016/j.jcjo.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between tetracycline use and the development of short-term vision threatening complications (VTC) among patients with diabetic retinopathy (DR).</div></div><div><h3>Methods</h3><div>Using a deidentified database, 4 596 patients with severe nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) associated with tetracycline use versus 87,974 patients with NPDR or PDR but no tetracycline use, respectively, were included before propensity score matching (PSM). After PSM, 4 576 patients in each cohort were analyzed. Incidence of developing VTC, including diabetic macular edema (DME), vitreous hemorrhage (VH), tractional retinal detachment (TRD), neovascular glaucoma (NVG), and subsequent need for ocular interventions including intravitreal anti-vascular endothelial growth factor (VEGF) injections, panretinal photocoagulation (PRP), or pars plana vitrectomy (PPV).</div></div><div><h3>Results</h3><div>Patients with DR and repeated tetracycline use had a reduced risk of developing DME (RR: 0.45, 95% CI: 0.28–0.72; <em>p</em> = 0.009) and VH (RR: 0.37, 95% CI: 0.20–0.69; <em>p</em> = 0.001) compared to the tetracycline-naive cohort at 6 months and 1 year. Further, there was a reduced risk of subsequent need for anti-VEGF (RR: 0.25, 95% CI: 0.13–0.47; <em>p</em> = 0.003) and PRP (RR: 0.40, 95% CI: 0.19–0.84; <em>p</em> = 0.012) in the tetracycline cohort compared to the tetracycline-naive group at 6 months and 1 year. There were no significant differences in the development of NVG, TRD, or the requirement for PPV between both cohorts.</div></div><div><h3>Conclusions</h3><div>Repeated tetracycline use was associated with a potentially reduced short-term risk of developing DME, VH, and needing subsequent anti-VEGF or PRP therapy versus tetracycline naive patients.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 6","pages":"Pages e858-e868"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular fibrosis in neovascular AMD: inter-reader and intermodality variability across four imaging modalities 新生血管性AMD的黄斑纤维化：四种成像模式的解读器间和模态间变异性。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.05.019

Andrea Coletto , Sonia Serafino , Chiara Olivieri , Valentina Marica , Pasquale Viggiano , Veronica Vallino , Paola Marolo , Enrico Borrelli , Michele Reibaldi

Objective

To assess inter-reader and intermodality variability in quantifying macular fibrosis in patients with neovascular age-related macular degeneration (AMD) using 4 imaging modalities: color fundus photography (CFP), near-infrared reflectance (NIR), structural optical coherence tomography (OCT), and MultiColor imaging.

Design

Prospective, cross-sectional case series.

Participants

Thirty eyes of 30 patients with neovascular AMD and macular fibrosis, previously treated with anti-vascular endothelial growth factor therapy.

Methods

Imaging was performed using CFP, NIR, structural OCT, and MultiColor modalities. Two masked graders evaluated the size of macular fibrosis using each modality. The study assessed inter-reader agreement using the intraclass correlation coefficient (ICC), coefficient of variation (CV), and 95% coefficient of repeatability. Intermodality variability was analyzed using repeated measures ANOVA and pairwise comparisons.

Results

Structural OCT demonstrated the highest inter-reader agreement (ICC = 0.983; CV = 0.04), while NIR exhibited the lowest (ICC = 0.461; CV = 0.26). The median macular fibrosis size was largest on structural OCT (4.87 mm²) and smallest on MultiColor imaging (2.03 mm²). Significant differences were observed between imaging modalities, with fibrosis measurements from different modalities not consistently comparable.

Conclusions

Structural OCT is the most reliable modality for quantifying macular fibrosis in neovascular AMD. The observed intermodality variability highlights the need for standardized criteria in fibrosis assessment across imaging techniques, as differences can impact clinical interpretation and management.

目的：利用彩色眼底摄影（CFP）、近红外反射（NIR）、结构光学相干断层扫描（OCT）和多色成像等4种成像方式，评估新生血管性年龄相关性黄斑变性（AMD）患者黄斑纤维化量化的读者间和模态间变异性。设计：前瞻性，横断面病例系列。参与者：30例新血管性AMD合并黄斑纤维化患者，30只眼，既往接受过抗血管内皮生长因子治疗。方法：采用CFP、近红外、结构OCT和多色成像。两名蒙面评分者使用每种方式评估黄斑纤维化的大小。该研究使用类内相关系数（ICC）、变异系数（CV）和95%可重复性系数评估读者间一致性。使用重复测量ANOVA和两两比较分析模态间变异性。结果：结构OCT的读者间一致性最高(ICC = 0.983；CV = 0.04)，而NIR表现最低(ICC = 0.461；简历 = 0.26)。黄斑纤维化中位数在结构OCT上最大（4.87 mm²），在多色成像上最小（2.03 mm²）。不同成像方式之间观察到显著差异，不同方式的纤维化测量不具有一致性可比性。结论：结构OCT是量化新生血管性AMD黄斑纤维化最可靠的方法。观察到的多模式差异强调了跨成像技术评估纤维化的标准化标准的必要性，因为差异会影响临床解释和管理。

{"title":"Macular fibrosis in neovascular AMD: inter-reader and intermodality variability across four imaging modalities","authors":"Andrea Coletto , Sonia Serafino , Chiara Olivieri , Valentina Marica , Pasquale Viggiano , Veronica Vallino , Paola Marolo , Enrico Borrelli , Michele Reibaldi","doi":"10.1016/j.jcjo.2025.05.019","DOIUrl":"10.1016/j.jcjo.2025.05.019","url":null,"abstract":"<div><h3>Objective</h3><div>To assess inter-reader and intermodality variability in quantifying macular fibrosis in patients with neovascular age-related macular degeneration (AMD) using 4 imaging modalities: color fundus photography (CFP), near-infrared reflectance (NIR), structural optical coherence tomography (OCT), and MultiColor imaging.</div></div><div><h3>Design</h3><div>Prospective, cross-sectional case series.</div></div><div><h3>Participants</h3><div>Thirty eyes of 30 patients with neovascular AMD and macular fibrosis, previously treated with anti-vascular endothelial growth factor therapy.</div></div><div><h3>Methods</h3><div>Imaging was performed using CFP, NIR, structural OCT, and MultiColor modalities. Two masked graders evaluated the size of macular fibrosis using each modality. The study assessed inter-reader agreement using the intraclass correlation coefficient (ICC), coefficient of variation (CV), and 95% coefficient of repeatability. Intermodality variability was analyzed using repeated measures ANOVA and pairwise comparisons.</div></div><div><h3>Results</h3><div>Structural OCT demonstrated the highest inter-reader agreement (ICC = 0.983; CV = 0.04), while NIR exhibited the lowest (ICC = 0.461; CV = 0.26). The median macular fibrosis size was largest on structural OCT (4.87 mm²) and smallest on MultiColor imaging (2.03 mm²). Significant differences were observed between imaging modalities, with fibrosis measurements from different modalities not consistently comparable.</div></div><div><h3>Conclusions</h3><div>Structural OCT is the most reliable modality for quantifying macular fibrosis in neovascular AMD. The observed intermodality variability highlights the need for standardized criteria in fibrosis assessment across imaging techniques, as differences can impact clinical interpretation and management.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 6","pages":"Pages e906-e914"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alexia without agraphia secondary to glioblastoma multiforme 多形性胶质母细胞瘤继发的失读症，无书写障碍。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.06.009

Rui Tang , Rhys Ishihara , Pamela Davila Siliezar , Noor A. Laylani , Peter Mortensen , Andrew G. Lee

引用次数: 0

Hydrophilic intraocular lens with crystalline deposits 有结晶沉积的亲水人工晶体。

IF 2.8 4区医学 Q1 OPHTHALMOLOGY

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Pub Date : 2025-12-01 DOI: 10.1016/j.jcjo.2025.08.010

Turner D. Wibbelsman , Heather Skeens , Ralph C. Eagle Jr.

引用次数: 0

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