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Unmasking the Enigma: Influenza Vaccine and the Rare Case of Post-Vaccination Pericarditis. 揭开谜底:流感疫苗与接种后心包炎的罕见病例。
IF 1.1 Pub Date : 2024-03-09 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2729208
Ekrem Yetiskul, Alaukika Agarwal, Gaetano Di Pietro, Faris Qaqish, Salman Khan, Shahkar Khan

Acute pericarditis is an inflammatory condition involving the pericardium, the double-layered sac that surrounds the heart. It is characterized by chest pain, typically pleuritic and sharp, along with other clinical and laboratory findings indicative of pericardial inflammation. While acute pericarditis following influenza vaccination is rare, it has been reported in medical literature. The relationship between vaccinations, including the influenza vaccine, and pericarditis is particularly interesting, as it has implications for public health and vaccination programs. Understanding the pathophysiological mechanisms behind vaccine-induced pericarditis and recognizing the clinical presentation are essential for healthcare professionals to diagnose, manage, and educate patients appropriately.

急性心包炎是一种涉及心包的炎症,心包是环绕心脏的双层囊。其特征是胸痛,典型的胸膜炎性剧痛,以及其他表明心包炎症的临床和实验室检查结果。虽然接种流感疫苗后发生急性心包炎的情况很少见,但医学文献中也有报道。包括流感疫苗在内的疫苗接种与心包炎之间的关系尤其引人关注,因为它对公共卫生和疫苗接种计划具有重要意义。了解疫苗诱发心包炎背后的病理生理机制并识别其临床表现对于医护人员诊断、管理和教育患者至关重要。
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引用次数: 0
Aspergillus fumigatus Epidural Abscess and Postsurgical Wound Infection in an Immunocompetent Host. 免疫功能正常的宿主硬膜外脓肿和手术后伤口感染的曲霉菌。
IF 1.1 Pub Date : 2024-02-29 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8104167
Nadine Montreuil, Andres Martinez, Leon Budrie, Shriya Goyal, Tanya Quiroz, Christine Vu, Folusakin Ayoade, Candice A Sternberg

In this case, we present an immunocompetent patient who had a wound infection secondary to Aspergillus fumigatus after undergoing a neurosurgical procedure that was complicated by an epidural abscess. The patient was treated with voriconazole and responded favorably. We highlight the need for awareness of the possibility of an Aspergillus infection in people without any obvious immunocompromise and advocate for the inclusion of this opportunistic fungus in the workup of postneurosurgical infections and dura-based collections. A brief review of relevant literature is also included.

在本病例中,我们介绍了一名免疫功能正常的患者,该患者在接受神经外科手术后继发了伤口感染,并发硬膜外脓肿。患者接受了伏立康唑治疗,效果良好。我们强调有必要认识到无明显免疫力低下者感染曲霉菌的可能性,并主张将这种机会性真菌纳入神经外科术后感染和硬脑膜脓肿的检查中。本文还简要回顾了相关文献。
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引用次数: 0
A Man in His Forties with Recurrent Cat-Scratch Disease. 一名四十多岁的男子反复患猫抓病。
IF 1.1 Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4411133
Sara López-Rueda, Benjamin Valente-Acosta, Adrian Murillo-Zolezzi, Francisco Moreno-Sánchez, Irma Hoyo-Ulloa, Jesús Javier Baquera-Heredia

Cat-scratch disease (CSD) is a self-limited zoonotic infection transmitted by felines caused by the Gram-negative bacillus Bartonella henselae. It usually presents with lymphadenopathy and constitutional symptoms that resolve within eight weeks, with, or without antibiotic treatment. The diagnosis is made by serology, molecular diagnosis in a biopsy, or a positive culture. The recurrence or reactivation of B. henselae has rarely been reported. We present the case of a 45-year-old man with a history of CSD two years before who presented to the clinic with groin lymphadenopathy. The patient had a history of close contact with felines though no known risk exposure was reported. The diagnosis was made with a positive serology suggestive of recent infection along with histopathological changes suggestive of CSD. Subsequently, azithromycin was administered with complete resolution of symptoms.

猫抓病(CSD)是由革兰氏阴性杆菌鸡矢藤巴顿氏菌引起的猫科动物自限性传染病。该病通常表现为淋巴结肿大和全身症状,经抗生素治疗或不经抗生素治疗均可在八周内缓解。诊断可通过血清学、活检中的分子诊断或阳性培养进行。鸡疫杆菌复发或再活化的报道很少。我们接诊了一例 45 岁的男性患者,他两年前曾患 CSD,后因腹股沟淋巴结病就诊。患者有与猫科动物密切接触的历史,但没有报告已知的风险暴露。血清学检查呈阳性,提示近期感染,组织病理变化提示 CSD,因此确诊。随后,患者接受了阿奇霉素治疗,症状完全缓解。
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引用次数: 0
Flea-Borne Typhus as a COVID-19 Mimic: A Report of Four Cases 跳蚤传播的斑疹伤寒是 COVID-19 的模拟物:四例病例报告
IF 1.1 Pub Date : 2024-02-14 DOI: 10.1155/2024/9914306
Bradley V. Dye, Jose Alejandro Coba, Christopher L. Dayton, Jose Cadena, Gregory M. Anstead
Flea-borne typhus (FBT), due to Rickettsia typhi and R. felis, is an infection causing fever, headache, rash, hepatitis, thrombocytopenia, and diverse organ manifestations. Cough occurs in about 30% of patients with FBT, and chest X-ray abnormalities are seen in 17%. Severe pulmonary manifestations have also been reported in FBT, including adult respiratory distress syndrome and pulmonary embolism. Because of these pulmonary manifestations, FBT can mimic Coronavirus Illness 2019 (COVID-19), a febrile illness with prominent respiratory involvement. Flea-borne typhus and COVID-19 may also have similar laboratory abnormalities, including elevated ferritin, C-reactive protein, and D-dimer. However, elevated transaminase levels, rash, and thrombocytopenia are more common in FBT. Herein, we present four cases of patients with FBT who were initially suspected to have COVID-19. These cases illustrate the problem of availability bias, in which the clinician thinks a particular common condition (COVID-19 in this case) is more prevalent than it actually is.
跳蚤传播斑疹伤寒(FBT)是由伤寒立克次体和鼠伤寒立克次体引起的一种感染,可导致发热、头痛、皮疹、肝炎、血小板减少和多种器官表现。约30%的FBT患者会出现咳嗽,17%的患者会出现胸部X光异常。也有报道称,FBT 患者会出现严重的肺部表现,包括成人呼吸窘迫综合征和肺栓塞。由于这些肺部表现,FBT 可模拟冠状病毒病 2019(COVID-19),这是一种发热性疾病,主要累及呼吸道。跳蚤传播的斑疹伤寒和COVID-19也可能有类似的实验室异常,包括铁蛋白、C反应蛋白和D-二聚体升高。然而,转氨酶水平升高、皮疹和血小板减少在FBT中更为常见。在此,我们介绍了四例最初被怀疑患有 COVID-19 的 FBT 患者。这些病例说明了可得性偏倚的问题,即临床医生认为某种常见疾病(本例中为 COVID-19)的发病率高于实际发病率。
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引用次数: 0
Flea-Borne Typhus as a COVID-19 Mimic: A Report of Four Cases 跳蚤传播的斑疹伤寒是 COVID-19 的模拟物:四例病例报告
IF 1.1 Pub Date : 2024-02-14 DOI: 10.1155/2024/9914306
Bradley V. Dye, Jose Alejandro Coba, Christopher L. Dayton, Jose Cadena, Gregory M. Anstead
Flea-borne typhus (FBT), due to Rickettsia typhi and R. felis, is an infection causing fever, headache, rash, hepatitis, thrombocytopenia, and diverse organ manifestations. Cough occurs in about 30% of patients with FBT, and chest X-ray abnormalities are seen in 17%. Severe pulmonary manifestations have also been reported in FBT, including adult respiratory distress syndrome and pulmonary embolism. Because of these pulmonary manifestations, FBT can mimic Coronavirus Illness 2019 (COVID-19), a febrile illness with prominent respiratory involvement. Flea-borne typhus and COVID-19 may also have similar laboratory abnormalities, including elevated ferritin, C-reactive protein, and D-dimer. However, elevated transaminase levels, rash, and thrombocytopenia are more common in FBT. Herein, we present four cases of patients with FBT who were initially suspected to have COVID-19. These cases illustrate the problem of availability bias, in which the clinician thinks a particular common condition (COVID-19 in this case) is more prevalent than it actually is.
跳蚤传播斑疹伤寒(FBT)是由伤寒立克次体和鼠伤寒立克次体引起的一种感染,可导致发热、头痛、皮疹、肝炎、血小板减少和多种器官表现。约30%的FBT患者会出现咳嗽,17%的患者会出现胸部X光异常。也有报道称,FBT 患者会出现严重的肺部表现,包括成人呼吸窘迫综合征和肺栓塞。由于这些肺部表现,FBT 可模拟冠状病毒病 2019(COVID-19),这是一种发热性疾病,主要累及呼吸道。跳蚤传播的斑疹伤寒和COVID-19也可能有类似的实验室异常,包括铁蛋白、C反应蛋白和D-二聚体升高。然而,转氨酶水平升高、皮疹和血小板减少在FBT中更为常见。在此,我们介绍了四例最初被怀疑患有 COVID-19 的 FBT 患者。这些病例说明了可得性偏倚的问题,即临床医生认为某种常见疾病(本例中为 COVID-19)的发病率高于实际发病率。
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引用次数: 0
Extrapulmonary Tuberculosis Leading to Abdominal Wall Mass in Young Patient. 导致年轻患者腹壁肿块的肺外结核病
IF 1 Q4 INFECTIOUS DISEASES Pub Date : 2024-02-05 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9924307
Mohadeseh Karimi, Ali AtashAbParvar

Background: Tuberculosis is a bacterial infection that is caused by Mycobacterium tuberculosis. Tuberculosis has arguably been the largest killer of humans historically, and it remains one of the most important infectious causes of death in the world. Tuberculosis can be classified into different forms and it manifests as pulmonary and out pulmonary, respectively, in 85% and 15% of cases. Only a few cases of tuberculosis with abdominal wall involvement have been reported. Case Presentation. Herein, we present a 27-year-old Persian woman, presented with asymmetric abdominal bulging in the right side of the periumbilical area since 6 months before admission that has no pain or secretion. The patient was oriented and not ill or toxic in general appearance. Vital signs were within normal ranges. An abdominal physical examination revealed a mobile, well-bordered, nontender mass 3 × 3 centimeter (cm) in diameter palpated in the right periumbilical area. The patient underwent surgery which revealed a cystic lesion that was carefully resected. In histopathology examination of the specimen resection, tuberculosis was confirmed.

Conclusion: We report a rare case of extrapulmonary tuberculosis that was identified at the abdominal wall. Due to the high number of cases of TB and the development of extrapulmonary forms that can present in an unusual location as an abdominal wall which are difficult to diagnose, it is very important to keep in mind the differential diagnosis of tuberculosis.

背景:结核病是由结核分枝杆菌引起的细菌感染。结核病可以说是人类历史上最大的杀手,至今仍是世界上最重要的传染性死亡原因之一。结核病可分为不同的形式,85%和 15%的病例分别表现为肺结核和肺外结核。腹壁受累的肺结核病例仅有少数报道。病例介绍。本病例是一名 27 岁的波斯妇女,入院前 6 个月出现右侧脐周不对称腹部隆起,无疼痛或分泌物。患者神志清楚,全身无不适或中毒症状。生命体征在正常范围内。腹部体格检查发现,右侧脐周触及一个直径为 3 × 3 厘米(cm)的活动、边界清楚、无触痛的肿块。患者接受了手术治疗,手术仔细切除了囊性病变。切除标本的组织病理学检查证实了结核病:我们报告了一例罕见的腹壁肺外结核病例。由于肺结核病例较多,而且肺外结核可能出现在腹壁这种难以诊断的异常部位,因此牢记肺结核的鉴别诊断非常重要。
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引用次数: 0
Genitourinary Blastomycosis in a Young Male Patient: A Case Report and Review of Diagnostic Challenges 一名年轻男性患者的泌尿生殖系统布氏杆菌病:病例报告和诊断难题回顾
IF 1.1 Pub Date : 2023-12-19 DOI: 10.1155/2023/4713948
Emily Hillman, Hangcheng Fu, Randa Obid, U. Anele
Disseminated blastomycosis is an endemic fungal infection that rarely manifests with genitourinary involvement. We present a unique case of a 28-year-old professional male gamer with a remote history of hemoptysis and cervical lymphadenopathy who presented with hematospermia, lower urinary tract symptoms (LUTS), and persistent groin abscesses after left orchiectomy at an outside hospital. He underwent drainage of groin abscess and prostate biopsy for an abnormal digital rectal exam which revealed disseminated blastomycosis requiring systemic, long-term antifungal treatment. We have also included a review of literature to note clinical patterns in presentations and highlight the diagnostic challenges that this infection presents.
播散性囊霉菌病是一种地方性真菌感染,很少表现为泌尿生殖系统受累。我们介绍了一例独特的病例,患者是一名 28 岁的职业男性游戏玩家,曾有咯血和颈部淋巴结病史,在一家外院接受左侧睾丸切除术后出现血精、下尿路症状(LUTS)和持续性腹股沟脓肿。他接受了腹股沟脓肿引流术,并因数字直肠检查异常而接受了前列腺活检,结果显示他患上了播散性囊霉菌病,需要长期全身抗真菌治疗。我们还对文献进行了回顾,以注意临床表现的模式,并强调这种感染所带来的诊断难题。
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引用次数: 0
Persistent, Poorly Responsive Immune Thrombocytopenia Secondary to Asymptomatic COVID-19 Infection in a Child 一名儿童继发于无症状 COVID-19 感染的持续性、反应性差的免疫性血小板减少症
IF 1.1 Pub Date : 2023-12-15 DOI: 10.1155/2023/3298520
C. Mettananda, Senani Williams
Immune thrombocytopenic purpura (ITP) secondary to asymptomatic COVID-19 infection, especially in children, is not reported. Furthermore, persistent, treatment-resistant ITP secondary to COVID-19 is not reported. We report a previously healthy 14-year-old Asian boy who developed secondary ITP following an asymptomatic COVID-19 infection and is having a relapsing and remitting cause with poor response to immunosuppressants even after 21 months following the diagnosis. This case emphasizes the importance of testing for COVID-19 in newly diagnosed ITP patients and the need for follow-up platelet counts in patients who recover from COVID-19 as it may follow into developing secondary ITP yet being asymptomatic until you present with a bleeding complication of ITP. The poor response to standard immunosuppression warrants more understanding of the pathophysiology of persistently low platelets following COVID-19 infection. Long-term sequelae of the disease highlight the importance of getting vaccinated for COVID-19 despite COVID-19 being no longer a global emergency.
因无症状感染 COVID-19 而继发免疫性血小板减少性紫癜(ITP)的病例(尤其是儿童)尚未见报道。此外,继发于 COVID-19 的持续性、耐药性 ITP 也未见报道。我们报告了一名之前身体健康的 14 岁亚洲男孩,他在无症状感染 COVID-19 后继发了 ITP,即使在确诊后 21 个月仍出现复发和缓解,且对免疫抑制剂反应不佳。本病例强调了对新诊断的 ITP 患者进行 COVID-19 检测的重要性,以及对从 COVID-19 感染中康复的患者进行血小板计数随访的必要性,因为 COVID-19 感染可能会导致继发性 ITP,但患者在出现 ITP 出血并发症之前并无症状。由于对标准免疫抑制的反应不佳,因此需要进一步了解 COVID-19 感染后血小板持续偏低的病理生理学。尽管COVID-19已不再是全球紧急事件,但该疾病的长期后遗症凸显了接种COVID-19疫苗的重要性。
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引用次数: 0
Bacteroides fragilis Acute Hematogenous Osteomyelitis in a Young Female with Sickle Cell Disease 一名患有镰状细胞病的年轻女性体内的脆弱拟杆菌急性血源性骨髓炎
IF 1.1 Pub Date : 2023-12-05 DOI: 10.1155/2023/6340222
Nada Bassam Hamieh, Hiba Abdul Hamid Abou Layla, Rola Ali Ali, Zeina Bayram, Abdul Rahman Bizri
Patients with sickle cell disease are at increased risk for multiple infections including osteomyelitis. The most reported causative organisms are Salmonella spp. and Staphylococcus aureus. Anaerobic infections including Bacteroides fragilis are not commonly seen. Here, we report the first case of a 28-year-old female patient with sickle cell disease and acute hematogenous Bacteroides fragilis tibial osteomyelitis. Diagnosis was made by isolating the organism from blood and tibial fluid cultures. The patient was successfully managed with a course of intravenous followed by oral antibiotics and percutaneous drainage of collection and responded well. This case report will shed light on the importance of Bacteroides fragilis as a causative organism for osteomyelitis in sickle cell disease patients, thereby affecting the management of these patients.
镰状细胞病患者发生包括骨髓炎在内的多种感染的风险增加。报告最多的致病菌是沙门氏菌和金黄色葡萄球菌。包括脆弱拟杆菌在内的厌氧感染并不常见。在此,我们报告一例28岁女性镰状细胞病合并急性血源性脆弱拟杆菌性胫骨骨髓炎的病例。诊断是通过从血液和胫骨液培养中分离出生物体。患者成功地进行了一个疗程的静脉注射,随后口服抗生素和经皮引流收集,反应良好。本病例报告将阐明脆弱拟杆菌作为镰状细胞病患者骨髓炎的致病生物的重要性,从而影响这些患者的管理。
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引用次数: 0
A Case of Trueperella bernardiae Bacteremia due to a PICC-Associated Infection in a Paraplegic Patient 一例截瘫患者因 PICC 相关感染引发的伯纳氏真菌菌血症病例
IF 1.1 Pub Date : 2023-12-04 DOI: 10.1155/2023/6238339
Carter Chapman, Jacob Nichols
Trueperella bernardiae is a Gram-positive bacterium known to cause a wide variety of opportunistic infections in humans. We report a novel case of T. bernardiae bacteremia in a paraplegic patient due to a peripherally inserted central catheter- (PICC-) associated infection that was treated successfully with piperacillin/tazobactam.
伯纳真perella bernardiae是一种革兰氏阳性细菌,已知可引起人类多种机会性感染。我们报告了一个新的病例T. bernardiae菌血症在截瘫患者由于周围插入中心导管(PICC)相关感染,成功地治疗了哌拉西林/他唑巴坦。
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引用次数: 0
期刊
Case Reports in Infectious Diseases
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