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An Immunocompetent Adult Male Presented with a Liver Abscess Caused by the Mycobacterium tuberculosis: A Case Report from India. 一例免疫功能正常的成年男性出现由结核分枝杆菌引起的肝脓肿:一例来自印度的报告。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/9049315
Akash Pawar, Sagar Khadanga, Abhishek Singhai

A liver abscess is a collection of purulent fluid in the liver parenchyma caused by a variety of etiological organisms such as bacteria, protozoa, and in rare occasions fungi. Mycobacterium tuberculosis (MTB) is a frequent and widespread infection in underdeveloped nations such as India, which can manifest in many ways. Tuberculosis mostly affects the lungs, although it can also affect any organ in the body. We are reporting a case of liver abscess caused by MTB infection in order to raise general awareness among physicians about the importance of suspecting and ruling out tuberculosis as a cause of liver abscess. To the best of our knowledge, there have been very few such cases reported from India/the rest of the world.

肝脓肿是肝实质中化脓性液体的集合,由多种病原生物如细菌、原生动物和罕见的真菌引起。结核分枝杆菌(MTB)在印度等不发达国家是一种常见和广泛的感染,它可以以多种方式表现出来。结核病主要影响肺部,尽管它也可以影响身体的任何器官。我们报告一例由结核分枝杆菌感染引起的肝脓肿,以提高医生对怀疑和排除结核作为肝脓肿原因的重要性的普遍认识。据我们所知,印度和世界其他地方报道的此类病例很少。
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引用次数: 0
Successful Treatment of a Case of Metallo-Beta-Lactamase-Producing Raoultella ornithinolytica Bacteremia by Antimicrobial Stewardship Team Intervention and Therapeutic Drug Monitoring-Based Amikacin Treatment. 抗菌管理团队干预和基于治疗药物监测的阿米卡星治疗溶鸟嘌呤拉乌尔菌血症1例
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/5574769
Noriko Koishi, Hiroshi Sasano, Toshihiro Yoshizawa, Mika Shikuri, Hiroshi Matsumoto, Mai Suzuki, Yukiko Fukui, Masayoshi Chonan, Toshimi Kimura, Hirofumi Ichida, Akio Saiura, Toshio Naito

An 80-year-old woman underwent pancreatoduodenectomy. Post-operation, she experienced a fever, and a culture of blood revealed metallo-beta-lactamase-producing Raoultella ornithinolytica. For treatments with aminoglycoside antimicrobial agents, a therapeutic drug monitoring-based dosing design can lower the risk of adverse events and enable appropriate treatment. Key Clinical Message. When aminoglycoside antimicrobial agents are administered for MBL-producing bacteremia, prescription suggestions based on TDM by antimicrobial stewardship team can reduce the occurrence of adverse events and enable appropriate treatment.

一位80岁的妇女接受了胰十二指肠切除术。手术后,她出现发烧,血液培养显示产生金属- β -内酰胺酶的溶鸟拉乌尔菌。对于氨基糖苷类抗菌剂的治疗,基于治疗药物监测的剂量设计可以降低不良事件的风险,并使适当的治疗成为可能。关键临床信息。当氨基糖苷类抗菌药物用于产生mbl的菌血症时,抗菌药物管理团队根据TDM提出的处方建议可以减少不良事件的发生,并使适当的治疗成为可能。
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引用次数: 0
Acute Hepatitis A and Hepatitis B Coinfection in a Young Female: A Case Report and Literature Review. 1例年轻女性急性甲型肝炎和乙型肝炎合并感染:1例报告和文献复习。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/1809020
Narges Lashkarbolouk, Behnaz Khodabakhshi, Mahdi Mazandarani

Background: Hepatitis is one of the common infectious diseases that can infect patients in various forms. Based on their characteristics and clinical features, they can cause irreparable complications in patients. Coinfections and superinfections between its variant have been reported, but the coinfection of acute HAV and HBV is rarely reported. Case Presentation. In this case report, we presented a case with severe malaise, nausea, vomiting, generalized jaundice, and a history of recent tattooing and travel to the HAV endemic area. In our evaluation, she had a positive HBsAg, HBeAg, anti-HBs IgM, anti-HAV IgM, and negative result in HCV antibody, HIV antibody, and anti-HAV IgG. The coinfection of HAV/HBV was confirmed for her.

Conclusion: Physicians should differentiate hepatitis A and hepatitis B superinfection or coinfection, based on history and laboratory testing, to prevent complications with appropriate treatment.

背景:肝炎是一种常见的传染病,其感染形式多种多样。基于它们的特点和临床特征,它们会给患者造成不可修复的并发症。其变体之间的共感染和重复感染已有报道,但急性甲肝病毒与乙型肝炎病毒的共感染鲜有报道。案例演示。在这个病例报告中,我们提出了一个严重不适,恶心,呕吐,全身性黄疸的病例,最近有纹身史和去过甲肝流行地区。在我们的评估中,她有HBsAg, HBeAg,抗hbs IgM,抗hav IgM阳性,HCV抗体,HIV抗体,抗hav IgG阴性。确诊为HAV/HBV合并感染。结论:医生应根据病史和实验室检查,区分甲型肝炎和乙型肝炎合并感染或合并感染,预防并发症并给予适当治疗。
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引用次数: 0
Streptococcus Pneumoniae Bacteremia with Acute Kidney Injury and Transient ADAMTS13 Deficiency. 肺炎链球菌菌血症伴急性肾损伤和短暂性ADAMTS13缺乏。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/3283606
Sam Van Hove, Alexis Werion, Ahalieyah Anantharajah, Leila Belkhir, Marie-Astrid van Dievoet, Philippe Hantson

A 43-year-old woman with a medical history of splenectomy for immune thrombocytopenic purpura was diagnosed with Streptococcus pneumoniae bacteremia. Her initial complaints were fever and more importantly painful extremities that appeared cyanotic. During her hospitalisation, she never developed cardiocirculatory failure but presented acute kidney injury (AKI) with oliguria. Laboratory investigations confirmed AKI with serum creatinine 2.55 mg/dL which peaked at 6.49 mg/dL. There was also evidence for disseminated intravascular coagulation (DIC) with decreased platelet count, low fibrinogen levels, and high D-dimer levels. There were no signs of haemolytic anaemia. The initial ADAMTS13 activity was low (17%) but slowly recovered. Renal function progressively improved with supportive therapy, as opposed to the progressing skin necrosis. The association of DIC and low ADAMTS13 activity may have contributed to the severity of microthrombotic complications, even in the absence of thrombotic microangiopathy as thrombotic thrombocytopenic purpura (TTP) or pneumococcal-associated haemolytic uremic syndrome (pa-HUS).

43岁女性,因免疫性血小板减少性紫癜而行脾切除术,诊断为肺炎链球菌菌血症。她最初的主诉是发烧,更重要的是四肢疼痛,呈紫绀。在住院期间,她从未出现过心循环衰竭,但出现了急性肾损伤(AKI)伴少尿。实验室检查证实AKI血清肌酐为2.55 mg/dL,峰值为6.49 mg/dL。也有证据表明弥散性血管内凝血(DIC)伴血小板计数减少、纤维蛋白原水平低和d -二聚体水平高。没有溶血性贫血的迹象。最初的ADAMTS13活性较低(17%),但恢复缓慢。与皮肤坏死进展相反,在支持治疗下肾功能逐渐改善。DIC和低ADAMTS13活性的关联可能导致了微血栓并发症的严重程度,即使在没有血栓性微血管病变的情况下,如血栓性血小板减少性紫癜(TTP)或肺炎球菌相关溶血性尿毒症综合征(pa-HUS)。
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引用次数: 0
Aspergillus Coinfection in a Hydatid Cyst Cavity of Lung in an Immunocompetent Host: A Case Report and Review of Literature. 免疫正常宿主肺包虫囊腔内曲霉共感染一例报告及文献复习。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/6975041
Aayush Adhikari, Surendra Khanal, Sagar Rana Magar, Srijana Thapa, Srijana Khati, Rajan Lamichhane, Kundan Marasini

Aspergilloma (a saprophytic infection) typically colonizes lung cavities due to underlying diseases such as tuberculosis, bronchiectasis, cavitary lung cancer, sarcoidosis, and pulmonary infarctions. Rarely, aspergilloma has been noted within a hydatid cyst. Even if this was the case, it is more common to find the coexistence of aspergilloma and pulmonary echinococcal cysts in immunocompromised individuals. It is, however, very uncommon to find this coinfection in normal immune status individuals. Here, we report on the successfully treated case of a 30-year-old immunocompetent female from Western Nepal with histologically proven coinfection by these two pathogens. She had a prolonged history of exposure to domesticated dogs. She suffered from hemoptysis from time to time for 3 years with increased frequency in the last 30 days. She was misdiagnosed clinically during a past medical visit at a local health center. Her computed tomography (CT) scans showed well-defined nonenhancing cystic lesions in the anterior basal segment of the right lower lobe adjacent to the major fissure. She underwent enucleation of the cyst via right posterolateral thoracotomy. On further histopathological evaluation, laminated membranes of the ectocyst along with fungal elements were found, and periodic acid-Schiff (PAS) staining revealed Aspergillus in the form of septate hyphae and acute angle branching. Owing to patient's economic constraints and unavailability in our center, DNA testing and molecular characterization could not be performed which further highlights the essence of diagnosing and managing such cases in resource poor settings. Eventually, we reviewed 12 confirmed cases of this coinfection in immunocompetent individuals during a period of 7 years (2015-2022) comparing them to a systematic review of 22 confirmed cases of the same coinfection from 1995 to 2014.

曲霉菌瘤(一种腐生性感染)通常是由于潜在疾病如肺结核、支气管扩张、空腔性肺癌、结节病和肺梗死而在肺腔中定植的。很少在包虫病中发现曲菌瘤。即使是这种情况,在免疫功能低下的个体中,更常见的是发现曲菌瘤和肺棘球蚴囊肿共存。然而,在正常免疫状态的个体中发现这种合并感染是非常罕见的。在这里,我们报告了一例成功治疗的来自尼泊尔西部的30岁免疫功能正常的女性,组织学证实了这两种病原体的共同感染。她长期与家犬接触。3年来不时咯血,最近30天咯血频率增加。她过去在当地一家医疗中心就诊时被误诊。她的计算机断层扫描(CT)显示在右下叶前基段靠近主要裂缝处有明确的无增强的囊性病变。她通过右后外侧开胸手术摘除囊肿。在进一步的组织病理学检查中,发现外胚囊的层状膜和真菌成分,周期性酸希夫(PAS)染色显示曲霉以分隔菌丝和锐角分支的形式存在。由于患者经济条件的限制和我们中心的不可获得性,无法进行DNA检测和分子鉴定,这进一步突出了在资源匮乏的情况下诊断和管理此类病例的重要性。最后,我们回顾了7年间(2015-2022年)免疫正常个体中12例确诊的这种合并感染病例,并将其与1995年至2014年22例确诊的相同合并感染病例进行了系统回顾。
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引用次数: 0
Concurrent Ocular and Cerebral Toxoplasmosis in a Liver Transplant Patient Treated with Anti-CD40 Monoclonal Antibody. 抗cd40单克隆抗体治疗肝移植患者并发眼脑弓形虫病
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/5565575
Roos Van Den Noortgate, Maja Kiselinova, Céline Sys, Geraldine Accou, Guy Laureys, Hans Van Vlierberghe, Frederik Berrevoet, Elke O Kreps

Toxoplasma gondii, an obligate intracellular parasitic protozoon, usually causes a mild, acute infection followed by a latent asymptomatic phase with tissue cysts or a chronic form with recurrent retinochoroiditis. However, immunocompromised patients can cause disseminated disease due to the reactivation of the latent tissue cysts or due to a primary infection. Here, we present a rare case of bilateral ocular toxoplasmosis and concurrent subacute toxoplasma encephalitis in a 70-year-old patient on anti-CD40 treatment following his liver transplant. The diagnosis was confirmed by PCR of anterior chamber fluid and brain biopsy, and no other sites of disseminated disease were detected on PET-CT. The patient has been treated with sulfamethoxazole-trimethoprim 800/160 mg with virtually complete resolution of the neurological and ocular symptoms. Iatrogenic blockade of the CD40 pathway may elicit a particular susceptibility for CNS reactivation of T. gondii.

刚地弓形虫是一种专性细胞内寄生原虫,通常引起轻微的急性感染,随后是潜伏的无症状期,伴有组织囊肿或慢性形式,伴复发性视网膜脉络膜炎。然而,由于潜伏组织囊肿的再激活或由于原发性感染,免疫功能低下的患者可引起播散性疾病。在此,我们报告一例罕见的双侧眼弓形虫病并发亚急性弓形虫脑炎的病例,患者为70岁,肝移植后接受抗cd40治疗。经前房液PCR及脑组织活检证实诊断,PET-CT未检出其他播散性病变部位。患者已接受磺胺甲恶唑-甲氧苄啶800/160 mg治疗,神经和眼部症状几乎完全缓解。医源性阻断CD40通路可能引起弓形虫中枢神经系统再激活的特殊易感性。
{"title":"Concurrent Ocular and Cerebral Toxoplasmosis in a Liver Transplant Patient Treated with Anti-CD40 Monoclonal Antibody.","authors":"Roos Van Den Noortgate,&nbsp;Maja Kiselinova,&nbsp;Céline Sys,&nbsp;Geraldine Accou,&nbsp;Guy Laureys,&nbsp;Hans Van Vlierberghe,&nbsp;Frederik Berrevoet,&nbsp;Elke O Kreps","doi":"10.1155/2023/5565575","DOIUrl":"https://doi.org/10.1155/2023/5565575","url":null,"abstract":"<p><p><i>Toxoplasma gondii</i>, an obligate intracellular parasitic protozoon, usually causes a mild, acute infection followed by a latent asymptomatic phase with tissue cysts or a chronic form with recurrent retinochoroiditis. However, immunocompromised patients can cause disseminated disease due to the reactivation of the latent tissue cysts or due to a primary infection. Here, we present a rare case of bilateral ocular toxoplasmosis and concurrent subacute toxoplasma encephalitis in a 70-year-old patient on anti-CD40 treatment following his liver transplant. The diagnosis was confirmed by PCR of anterior chamber fluid and brain biopsy, and no other sites of disseminated disease were detected on PET-CT. The patient has been treated with sulfamethoxazole-trimethoprim 800/160 mg with virtually complete resolution of the neurological and ocular symptoms. Iatrogenic blockade of the CD40 pathway may elicit a particular susceptibility for CNS reactivation of <i>T. gondii</i>.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10323906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of Acute Severe Necrotizing Pancreatitis following the Johnson & Johnson Vaccine against the Novel SARS-CoV-2. 强生新型SARS-CoV-2疫苗致急性重症坏死性胰腺炎1例报告
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/9965435
Ayrton I Bangolo, Mahabuba Akhter, Auda Auda, Rahina Akram, Vignesh K Nagesh, Donnee Athem, Reenu Thomas, Ligaya Tibalan, Mansi Trivedi, Saima Mushtaq, Neha Singh, Pracheta Bagale, Georgemar V Arana, Tayyaba Khan, Shelja Sharma, Swetha Mynedi, Dhara D Patel, Mandeep Saini, Madhurya R Chinthakuntla, Kareem Ahmed, Mary Gad, Srikara Dheer D R Gondhi, Georgemar Arana, Rohini B Gurumoorthy, Simcha Weissman

Acute pancreatitis is an inflammatory condition, which is a leading gastrointestinal cause of hospitalization in the United States. Several conditions are associated with acute pancreatitis. More recently, there have been a few cases reported of acute pancreatitis following the Pfizer-BioNTech COVID-19 mRNA vaccine. To our knowledge, no cases of acute pancreatitis have been yet reported following the Johnson & Johnson's Janssen COVID-19 vaccine (J& J vaccine). Herein we report a 34-year-old male with no significant past medical history admitted with acute necrotizing pancreatitis, the day following the receipt of the J&J vaccine. Based on the Naranjo and the modified Naranjo scale, the patient met the requirements for probable drug induced pancreatitis. This case report has the objective to raise awareness of a potentially severe side effect of the J&J vaccine. We hope to use this case to support screening all patients for previous history of acute pancreatitis before administration of the J& J vaccine.

急性胰腺炎是一种炎症性疾病,是美国住院治疗的主要胃肠道原因。几种情况与急性胰腺炎有关。最近,有几例报告了辉瑞- biontech COVID-19 mRNA疫苗后的急性胰腺炎病例。据我们所知,在强生公司的杨森COVID-19疫苗(j&j疫苗)后,尚未报告急性胰腺炎病例。在此,我们报告一名34岁男性,没有明显的既往病史,在接受强生疫苗的第二天因急性坏死性胰腺炎入院。根据Naranjo量表及修改后的Naranjo量表,患者符合可能药物性胰腺炎的要求。本病例报告的目的是提高人们对强生疫苗潜在严重副作用的认识。我们希望用这个病例来支持在注射强生疫苗前筛查所有患者是否有急性胰腺炎病史。
{"title":"A Case Report of Acute Severe Necrotizing Pancreatitis following the Johnson & Johnson Vaccine against the Novel SARS-CoV-2.","authors":"Ayrton I Bangolo,&nbsp;Mahabuba Akhter,&nbsp;Auda Auda,&nbsp;Rahina Akram,&nbsp;Vignesh K Nagesh,&nbsp;Donnee Athem,&nbsp;Reenu Thomas,&nbsp;Ligaya Tibalan,&nbsp;Mansi Trivedi,&nbsp;Saima Mushtaq,&nbsp;Neha Singh,&nbsp;Pracheta Bagale,&nbsp;Georgemar V Arana,&nbsp;Tayyaba Khan,&nbsp;Shelja Sharma,&nbsp;Swetha Mynedi,&nbsp;Dhara D Patel,&nbsp;Mandeep Saini,&nbsp;Madhurya R Chinthakuntla,&nbsp;Kareem Ahmed,&nbsp;Mary Gad,&nbsp;Srikara Dheer D R Gondhi,&nbsp;Georgemar Arana,&nbsp;Rohini B Gurumoorthy,&nbsp;Simcha Weissman","doi":"10.1155/2023/9965435","DOIUrl":"https://doi.org/10.1155/2023/9965435","url":null,"abstract":"<p><p>Acute pancreatitis is an inflammatory condition, which is a leading gastrointestinal cause of hospitalization in the United States. Several conditions are associated with acute pancreatitis. More recently, there have been a few cases reported of acute pancreatitis following the Pfizer-BioNTech COVID-19 mRNA vaccine. To our knowledge, no cases of acute pancreatitis have been yet reported following the Johnson & Johnson's Janssen COVID-19 vaccine (J& J vaccine). Herein we report a 34-year-old male with no significant past medical history admitted with acute necrotizing pancreatitis, the day following the receipt of the J&J vaccine. Based on the Naranjo and the modified Naranjo scale, the patient met the requirements for probable drug induced pancreatitis. This case report has the objective to raise awareness of a potentially severe side effect of the J&J vaccine. We hope to use this case to support screening all patients for previous history of acute pancreatitis before administration of the J& J vaccine.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonged Intractable Hiccups Associated with HSV (I&II) Esophagitis and H. pylori Gastritis. 与HSV (I&II)食管炎和幽门螺杆菌胃炎相关的长时间顽固性呃逆。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/3561895
Christina Hopkins, Asha Bansari, Michael Ladna, Bahram Dideban

An immunocompetent male presented with an intractable hiccup. EGD revealed circumferential ulceration of middistal esophagus and biopsies confirmed HSV (I&II) esophagitis and H. pylori gastritis. He was prescribed triple therapy for H. pylori and acyclovir for HSV esophagitis. HSV esophagitis and H. pylori should be included in differential for intractable hiccups.

一名免疫功能正常的男性出现顽固性呃逆。EGD显示食管中远端圆周溃疡,活检证实HSV (i和ii)食管炎和幽门螺杆菌胃炎。医生给他开了三联疗法治疗幽门螺杆菌和治疗HSV食管炎的阿昔洛韦。HSV食管炎和幽门螺杆菌应包括在难治性呃嗝的鉴别。
{"title":"Prolonged Intractable Hiccups Associated with HSV (I&II) Esophagitis and <i>H. pylori</i> Gastritis.","authors":"Christina Hopkins,&nbsp;Asha Bansari,&nbsp;Michael Ladna,&nbsp;Bahram Dideban","doi":"10.1155/2023/3561895","DOIUrl":"https://doi.org/10.1155/2023/3561895","url":null,"abstract":"<p><p>An immunocompetent male presented with an intractable hiccup. EGD revealed circumferential ulceration of middistal esophagus and biopsies confirmed HSV (I&II) esophagitis and <i>H. pylori</i> gastritis. He was prescribed triple therapy for <i>H. pylori</i> and acyclovir for HSV esophagitis. HSV esophagitis and <i>H. pylori</i> should be included in differential for intractable hiccups.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Adult Case of Adenovirus-Associated Acute Disseminated Encephalomyelitis. 成人腺病毒相关急性播散性脑脊髓炎1例。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/5528198
Dewayne Campbell, Gordon S Wong, Hyun Park, Gavin McLeod

Acute disseminated encephalomyelitis (ADEM) is an autoimmune neurological disease that predominately affects pediatric population. Only a single fatal adult case of adenovirus-associated ADEM has previously been published by Qamar et al. in 2021. Here, we present an adult case of adenovirus-associated ADEM, which was diagnosed early in her clinical course. The patient was treated with the prompt initiation of steroids, intravenous immune globulin (IVIG), and plasmapheresis (PLEX), and the patient recovered fully. This case highlights the importance of early accurate diagnosis for other clinicians to treat adenovirus-associated ADEM in a timely fashion to prevent a potentially fatal outcome.

急性播散性脑脊髓炎(ADEM)是一种主要影响儿童的自身免疫性神经系统疾病。Qamar等人在2021年仅发表了一例腺病毒相关ADEM致死成人病例。在这里,我们提出一个成人病例腺病毒相关的ADEM,这是诊断早期在她的临床过程。患者立即开始类固醇、静脉注射免疫球蛋白(IVIG)和血浆置换(PLEX)治疗,患者完全康复。该病例强调了早期准确诊断的重要性,以便其他临床医生及时治疗腺病毒相关的ADEM,以防止潜在的致命结果。
{"title":"An Adult Case of Adenovirus-Associated Acute Disseminated Encephalomyelitis.","authors":"Dewayne Campbell,&nbsp;Gordon S Wong,&nbsp;Hyun Park,&nbsp;Gavin McLeod","doi":"10.1155/2023/5528198","DOIUrl":"https://doi.org/10.1155/2023/5528198","url":null,"abstract":"<p><p>Acute disseminated encephalomyelitis (ADEM) is an autoimmune neurological disease that predominately affects pediatric population. Only a single fatal adult case of adenovirus-associated ADEM has previously been published by Qamar et al. in 2021. Here, we present an adult case of adenovirus-associated ADEM, which was diagnosed early in her clinical course. The patient was treated with the prompt initiation of steroids, intravenous immune globulin (IVIG), and plasmapheresis (PLEX), and the patient recovered fully. This case highlights the importance of early accurate diagnosis for other clinicians to treat adenovirus-associated ADEM in a timely fashion to prevent a potentially fatal outcome.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9567419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Lemierre Syndrome: A Diagnosis behind the Veil. 莱米尔综合征:面纱背后的诊断。
IF 1.1 Pub Date : 2023-01-01 DOI: 10.1155/2023/2273954
Pak-Ho Au, Kelechi Nwabara, Nanuli Gvazava, Shannon Ejiofor, Ghulam Ghous

Lemierre syndrome (LS) is a rare, serious infection that is often misdiagnosed, as it frequently mimics common upper respiratory infections. It is even rarer for LS to be preceded by a viral infection. We share a case of LS in a young man who presented to the Emergency Department with COVID-19 viral infection followed by a subsequent LS diagnosis. The patient's condition initially worsened despite treatments for COVID-19 and was subsequently started on broad-spectrum antibiotics. He was then diagnosed with LS after blood cultures grew Fusobacterium necrophorum, and antibiotics were adjusted accordingly, resulting in improvement of symptoms. Even though LS is often recognized as a sequela of bacterial pharyngitis, preceding viral infections, including COVID-19, might be a risk factor that contributes to the development of LS.

Lemierre综合征(LS)是一种罕见的严重感染,经常被误诊,因为它经常模仿常见的上呼吸道感染。更罕见的是,LS之前有病毒感染。我们分享了一位年轻男性的LS病例,他因COVID-19病毒感染而到急诊室就诊,随后被诊断为LS。尽管接受了COVID-19治疗,但患者的病情最初恶化,随后开始使用广谱抗生素。血液培养培养出坏死梭杆菌后被诊断为LS,并相应调整抗生素,症状得到改善。虽然LS通常被认为是细菌性咽炎的后遗症,但之前的病毒感染(包括COVID-19)可能是导致LS发展的危险因素。
{"title":"Lemierre Syndrome: A Diagnosis behind the Veil.","authors":"Pak-Ho Au,&nbsp;Kelechi Nwabara,&nbsp;Nanuli Gvazava,&nbsp;Shannon Ejiofor,&nbsp;Ghulam Ghous","doi":"10.1155/2023/2273954","DOIUrl":"https://doi.org/10.1155/2023/2273954","url":null,"abstract":"<p><p>Lemierre syndrome (LS) is a rare, serious infection that is often misdiagnosed, as it frequently mimics common upper respiratory infections. It is even rarer for LS to be preceded by a viral infection. We share a case of LS in a young man who presented to the Emergency Department with COVID-19 viral infection followed by a subsequent LS diagnosis. The patient's condition initially worsened despite treatments for COVID-19 and was subsequently started on broad-spectrum antibiotics. He was then diagnosed with LS after blood cultures grew <i>Fusobacterium necrophorum</i>, and antibiotics were adjusted accordingly, resulting in improvement of symptoms. Even though LS is often recognized as a sequela of bacterial pharyngitis, preceding viral infections, including COVID-19, might be a risk factor that contributes to the development of LS.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9363233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Case Reports in Infectious Diseases
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