{"title":"Bouger plus, bien vieillir : la prescription d’activité physique aux personnes aînées.","authors":"Jane S Thornton, William N Morley, Samir K Sinha","doi":"10.1503/cmaj.231336-f","DOIUrl":"10.1503/cmaj.231336-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E330-E339"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction à l’article « Homme de 58 ans présentant une ischémie digitale subaiguë aux 4 membres ».","authors":"","doi":"10.1503/cmaj.250394-f","DOIUrl":"10.1503/cmaj.250394-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 12","pages":"E344"},"PeriodicalIF":9.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orhan Yilmaz, Eleni Dimitra Bednar, Raed Alhusayen
{"title":"Advanced folliculotropic mycosis fungoides in a 66-year-old man with leonine facies.","authors":"Orhan Yilmaz, Eleni Dimitra Bednar, Raed Alhusayen","doi":"10.1503/cmaj.241602","DOIUrl":"10.1503/cmaj.241602","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E300"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Insuline icodec injectable à administration hebdomadaire pour les adultes vivant avec le diabète.","authors":"Sooyoun Shin, Catherine Yu","doi":"10.1503/cmaj.241037-f","DOIUrl":"10.1503/cmaj.241037-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E303-E304"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonpharmacologic management of the behavioural and psychological symptoms of dementia.","authors":"Hana Brath, Lesley Wiesenfeld, Nathan M Stall","doi":"10.1503/cmaj.241076","DOIUrl":"10.1503/cmaj.241076","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E298-E299"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Running in a storm.","authors":"Emily Groot","doi":"10.1503/cmaj.241116","DOIUrl":"10.1503/cmaj.241116","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E301-E302"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les personnes vivant avec le diabète mellitus.","authors":"Mike Bleskie, Rémi Rabasa-Lhoret, Cathy J Sun","doi":"10.1503/cmaj.241452-f","DOIUrl":"10.1503/cmaj.241452-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E305-E306"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gemma Postill, Ijeoma Uchenna Itanyi, M Ellen Kuenzig, Furong Tang, Vinyas Harish, Emma Buajitti, Laura Rosella, Eric I Benchimol
Background: Multimorbidity, the co-occurrence of 2 or more chronic conditions, is important in patients with inflammatory bowel disease (IBD) given its association with complex care plans, poor health outcomes, and excess mortality. Our objectives were to describe premature death (age < 75 yr) among people with IBD and to identify patterns between multimorbidity and premature death among decedents with IBD.
Methods: Using the administrative health data of people with IBD who died between 2010 and 2020 in Ontario, Canada, we conducted a population-based, retrospective cohort study. We described the proportion of premature deaths among people with IBD. We developed statistical and machine learning models to predict premature death from the presence of 17 chronic conditions and the patients' age at diagnosis. We evaluated models using accuracy, positive predictive value, sensitivity, F1 scores, area under the receiver operating curve (AUC), calibration plots, and explainability plots.
Results: All models showed strong performance (AUC 0.81-0.95). The best performing was the model that incorporated age at diagnosis for each chronic condition developed at or before age 60 years (AUC 0.95, 95% confidence interval 0.94-0.96). Salient features for predicting premature death were young ages of diagnosis for mood disorder, osteo-and other arthritis types, other mental health disorders, and hypertension, as well as male sex.
Interpretation: By comparing results from multiple approaches modelling the impact of chronic conditions on premature death among people with IBD, we showed that conditions developed early in life (age ≤ 60 yr) and their age of onset were important for predicting their health trajectory. Clinically, our findings emphasize the need for models of care that ensure people with IBD have access to high-quality, multidisciplinary health care.
{"title":"Machine learning prediction of premature death from multimorbidity among people with inflammatory bowel disease: a population-based retrospective cohort study.","authors":"Gemma Postill, Ijeoma Uchenna Itanyi, M Ellen Kuenzig, Furong Tang, Vinyas Harish, Emma Buajitti, Laura Rosella, Eric I Benchimol","doi":"10.1503/cmaj.241117","DOIUrl":"10.1503/cmaj.241117","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity, the co-occurrence of 2 or more chronic conditions, is important in patients with inflammatory bowel disease (IBD) given its association with complex care plans, poor health outcomes, and excess mortality. Our objectives were to describe premature death (age < 75 yr) among people with IBD and to identify patterns between multimorbidity and premature death among decedents with IBD.</p><p><strong>Methods: </strong>Using the administrative health data of people with IBD who died between 2010 and 2020 in Ontario, Canada, we conducted a population-based, retrospective cohort study. We described the proportion of premature deaths among people with IBD. We developed statistical and machine learning models to predict premature death from the presence of 17 chronic conditions and the patients' age at diagnosis. We evaluated models using accuracy, positive predictive value, sensitivity, F<sub>1</sub> scores, area under the receiver operating curve (AUC), calibration plots, and explainability plots.</p><p><strong>Results: </strong>All models showed strong performance (AUC 0.81-0.95). The best performing was the model that incorporated age at diagnosis for each chronic condition developed at or before age 60 years (AUC 0.95, 95% confidence interval 0.94-0.96). Salient features for predicting premature death were young ages of diagnosis for mood disorder, osteo-and other arthritis types, other mental health disorders, and hypertension, as well as male sex.</p><p><strong>Interpretation: </strong>By comparing results from multiple approaches modelling the impact of chronic conditions on premature death among people with IBD, we showed that conditions developed early in life (age ≤ 60 yr) and their age of onset were important for predicting their health trajectory. Clinically, our findings emphasize the need for models of care that ensure people with IBD have access to high-quality, multidisciplinary health care.</p>","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E286-E297"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les directives canadiennes devraient présenter le lait maternisé et l’allaitement naturel comme équivalents pour les parents dont la charge virale du VIH est supprimée.","authors":"Mona Loutfy, V Logan Kennedy","doi":"10.1503/cmaj.240441-f","DOIUrl":"10.1503/cmaj.240441-f","url":null,"abstract":"","PeriodicalId":9609,"journal":{"name":"Canadian Medical Association journal","volume":"197 11","pages":"E307-E308"},"PeriodicalIF":9.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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