Pub Date : 2025-12-24DOI: 10.1016/j.cell.2025.11.033
Jean-Philippe Courade, Henrik Zetterberg, Günter U. Höglinger, Ilse Dewachter
{"title":"The evolving landscape of Alzheimer’s disease therapy: From Aβ to tau","authors":"Jean-Philippe Courade, Henrik Zetterberg, Günter U. Höglinger, Ilse Dewachter","doi":"10.1016/j.cell.2025.11.033","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.033","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":"26 1","pages":"7337-7354"},"PeriodicalIF":64.5,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.cell.2025.11.029
Elizabeth V. Goldfarb
{"title":"Stimulants as agents of arousal in whole-brain functional connectivity","authors":"Elizabeth V. Goldfarb","doi":"10.1016/j.cell.2025.11.029","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.029","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":"131 1","pages":"7335-7336"},"PeriodicalIF":64.5,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.cell.2025.10.027
Matteo A. Molè, Sarah Elderkin, Irene Zorzan, Christopher Penfold, Nicole Horsley, Alexandra Pokhilko, Max Polanek, Andrea Palomar, Molika Sinha, Yang Wang, Alicia Quiñonero, Charalampos Androulidakis, Richard Acton, Kathryn Balmanno, Anneliese Jarman, Jhanavi Srinivasan, Adam Bendall, Sara Morales-Álvarez, Roberto Yagüe-Serrano, Katie Heywood, Stephen Harbottle, Mina Vasilic, Suzanne Cawood, Srividya Seshadri, Paul Serhal, Lauren Weavers, Ippokratis Sarris, Anastasia Mania, Rachel Gibbons, Lucy Laurier, Immaculada Sánchez-Ribas, Amparo Mercader, Pilar Alamá, Anthony Hoa Bui, Graham J. Burton, Tereza Cindrova-Davies, Ridma C. Fernando, Afshan McCarthy, Lusine Aghajanova, Liesl Nel-Themaat, Ruth B. Lathi, Simon J. Cook, Kathy K. Niakan, Alexander R. Dunn, Francisco Domínguez, Peter J. Rugg-Gunn
{"title":"Modeling human embryo implantation in vitro","authors":"Matteo A. Molè, Sarah Elderkin, Irene Zorzan, Christopher Penfold, Nicole Horsley, Alexandra Pokhilko, Max Polanek, Andrea Palomar, Molika Sinha, Yang Wang, Alicia Quiñonero, Charalampos Androulidakis, Richard Acton, Kathryn Balmanno, Anneliese Jarman, Jhanavi Srinivasan, Adam Bendall, Sara Morales-Álvarez, Roberto Yagüe-Serrano, Katie Heywood, Stephen Harbottle, Mina Vasilic, Suzanne Cawood, Srividya Seshadri, Paul Serhal, Lauren Weavers, Ippokratis Sarris, Anastasia Mania, Rachel Gibbons, Lucy Laurier, Immaculada Sánchez-Ribas, Amparo Mercader, Pilar Alamá, Anthony Hoa Bui, Graham J. Burton, Tereza Cindrova-Davies, Ridma C. Fernando, Afshan McCarthy, Lusine Aghajanova, Liesl Nel-Themaat, Ruth B. Lathi, Simon J. Cook, Kathy K. Niakan, Alexander R. Dunn, Francisco Domínguez, Peter J. Rugg-Gunn","doi":"10.1016/j.cell.2025.10.027","DOIUrl":"https://doi.org/10.1016/j.cell.2025.10.027","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":"26 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.cell.2025.11.030
Zhengyuan Pang, Verina H. Leung, Cailynn C. Wang, Ahmadreza Attarpour, Anthony Rinaldi, Hanbing Shen, Maria Dolores Moya-Garzon, Logan H. Sigua, Claire Rammel, Alexandra Selke, Christopher Glynn, Melaina Yender, Senhan Xu, Javid J. Moslehi, Peng Wu, Jonathan Z. Long, Maged Goubran, Benjamin F. Cravatt, Li Ye
As our understanding of biological systems reaches single-cell and high spatial resolutions, it becomes imperative that pharmacological approaches match this precision to understand drug actions. This need is particularly urgent for the targeted covalent inhibitors that are currently re-entering the stage for cancer treatments. By leveraging the unique kinetics of click reactions, we developed volumetric clearing-assisted tissue click chemistry (vCATCH) to enable deep and homogeneous click labeling across the three-dimensional (3D) mammalian body. With simple and passive incubation steps, vCATCH offers cellular-resolution drug imaging in the entire adult mouse. We combined vCATCH with hydrogel-based reinforcement of three-dimensional imaging solvent-cleared organs (HYBRiD) imaging and virtual reality to visualize and quantify in vivo targets of two clinical cancer drugs, afatinib and ibrutinib, which recapitulated their known pharmacological distribution and revealed previously unreported tissue and cell-type engagement potentially linked to off-target effects. vCATCH provides a body-wide, unbiased platform to map covalent drug engagements at unprecedented scale and precision.
{"title":"Mapping cellular targets of covalent cancer drugs in the entire mammalian body","authors":"Zhengyuan Pang, Verina H. Leung, Cailynn C. Wang, Ahmadreza Attarpour, Anthony Rinaldi, Hanbing Shen, Maria Dolores Moya-Garzon, Logan H. Sigua, Claire Rammel, Alexandra Selke, Christopher Glynn, Melaina Yender, Senhan Xu, Javid J. Moslehi, Peng Wu, Jonathan Z. Long, Maged Goubran, Benjamin F. Cravatt, Li Ye","doi":"10.1016/j.cell.2025.11.030","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.030","url":null,"abstract":"As our understanding of biological systems reaches single-cell and high spatial resolutions, it becomes imperative that pharmacological approaches match this precision to understand drug actions. This need is particularly urgent for the targeted covalent inhibitors that are currently re-entering the stage for cancer treatments. By leveraging the unique kinetics of click reactions, we developed volumetric clearing-assisted tissue click chemistry (vCATCH) to enable deep and homogeneous click labeling across the three-dimensional (3D) mammalian body. With simple and passive incubation steps, vCATCH offers cellular-resolution drug imaging in the entire adult mouse. We combined vCATCH with hydrogel-based reinforcement of three-dimensional imaging solvent-cleared organs (HYBRiD) imaging and virtual reality to visualize and quantify <em>in vivo</em> targets of two clinical cancer drugs, afatinib and ibrutinib, which recapitulated their known pharmacological distribution and revealed previously unreported tissue and cell-type engagement potentially linked to off-target effects. vCATCH provides a body-wide, unbiased platform to map covalent drug engagements at unprecedented scale and precision.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"184 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145801470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.cell.2025.11.027
Jessica Y. Huang, Michael Y. Gerner
Lymph nodes (LNs) enable innate defense to limit pathogen dissemination while also driving adaptive immunity. Yet, certain innate responses can restrict adaptive processes, suggesting that these must be tightly regulated. Here, we report that after infection or immunization, LN architecture is rapidly altered, with large-scale, polarized recruitment of neutrophils and monocytes from inflamed blood vessels and intranodal repositioning of natural killer (NK) cells. Mechanistically, dendritic cells (DCs) promote this through expression of inflammatory chemokines and integrin ligands. While these DC-driven innate responses are necessary for efficient pathogen containment, they paradoxically limit early adaptive immunity, with infiltrating neutrophils displacing lymphocytes and reducing the LN area available for T cell priming. Upon threat cessation, however, DCs and DC-recruited monocytes phagocytose the neutrophils, restoring tissue architecture and generating polarized domains for downstream adaptive immune cell activation. Thus, DCs orchestrate innate cell organization during inflammation, serving as rheostats of innate versus adaptive functions of the LN.
{"title":"Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense","authors":"Jessica Y. Huang, Michael Y. Gerner","doi":"10.1016/j.cell.2025.11.027","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.027","url":null,"abstract":"Lymph nodes (LNs) enable innate defense to limit pathogen dissemination while also driving adaptive immunity. Yet, certain innate responses can restrict adaptive processes, suggesting that these must be tightly regulated. Here, we report that after infection or immunization, LN architecture is rapidly altered, with large-scale, polarized recruitment of neutrophils and monocytes from inflamed blood vessels and intranodal repositioning of natural killer (NK) cells. Mechanistically, dendritic cells (DCs) promote this through expression of inflammatory chemokines and integrin ligands. While these DC-driven innate responses are necessary for efficient pathogen containment, they paradoxically limit early adaptive immunity, with infiltrating neutrophils displacing lymphocytes and reducing the LN area available for T cell priming. Upon threat cessation, however, DCs and DC-recruited monocytes phagocytose the neutrophils, restoring tissue architecture and generating polarized domains for downstream adaptive immune cell activation. Thus, DCs orchestrate innate cell organization during inflammation, serving as rheostats of innate versus adaptive functions of the LN.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"47 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.cell.2025.11.026
Min Kyung Shinn, Dylan T. Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M. Ruff, Gregory W. Strout, Matthew D. Lew, Kannanganattu V. Prasanth, Rohit V. Pappu
{"title":"Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases","authors":"Min Kyung Shinn, Dylan T. Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M. Ruff, Gregory W. Strout, Matthew D. Lew, Kannanganattu V. Prasanth, Rohit V. Pappu","doi":"10.1016/j.cell.2025.11.026","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.026","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":"35 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relationship with ESCC remains unclear. After improving the assay for transposase-accessible chromatin using sequencing (ATAC-seq) protocol for limited-amount clinical samples, we unravel transcription factor AP-2 beta (TFAP2β) as a key downregulated transcription factor (TF) through combined chromatin accessibility and gene expression analyses with cancerous and paracancerous tissues from early-stage ESCC patients. TFAP2β undergoes condensation in the nucleus to bind the zinc finger protein 131 (ZNF131) promoter, thereby inhibiting ZNF131 expression and ESCC progression. The other two crucial downregulated TFs uncovered are incorporated into TFAP2β condensates to bind their corresponding target, suggesting that LLPS may be a hallmark of ESCC transcription. In addition, we obtained compound A6 that mediates intrinsically disordered region conformational changes to enhance TFAP2β condensation and specific ESCC suppression in cells, mice, and patient-derived organoids. Thus, we indicate an LLPS-mediated transcriptional mechanism and a potential therapeutic approach for ESCC.
{"title":"Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma.","authors":"Zhaomin Deng, Lu Pu, Kai Deng, Wencheng Liu, Jifa Zhang, Liang Zhang, Qian Meng, Wanwan Zhou, Haoran Jin, Dongqin Xu, Shaochong Qi, Zhihan Wu, Yongxin Ma, Xing Liu, Xuebiao Yao, Bowen Ke, David J Kerr, Li Yang, Jinlin Yang, Hao Jiang","doi":"10.1016/j.cell.2025.11.019","DOIUrl":"10.1016/j.cell.2025.11.019","url":null,"abstract":"<p><p>Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relationship with ESCC remains unclear. After improving the assay for transposase-accessible chromatin using sequencing (ATAC-seq) protocol for limited-amount clinical samples, we unravel transcription factor AP-2 beta (TFAP2β) as a key downregulated transcription factor (TF) through combined chromatin accessibility and gene expression analyses with cancerous and paracancerous tissues from early-stage ESCC patients. TFAP2β undergoes condensation in the nucleus to bind the zinc finger protein 131 (ZNF131) promoter, thereby inhibiting ZNF131 expression and ESCC progression. The other two crucial downregulated TFs uncovered are incorporated into TFAP2β condensates to bind their corresponding target, suggesting that LLPS may be a hallmark of ESCC transcription. In addition, we obtained compound A6 that mediates intrinsically disordered region conformational changes to enhance TFAP2β condensation and specific ESCC suppression in cells, mice, and patient-derived organoids. Thus, we indicate an LLPS-mediated transcriptional mechanism and a potential therapeutic approach for ESCC.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":""},"PeriodicalIF":42.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.cell.2025.11.024
Claire J. Millett, James J. Shaver, Bernadette Bracken, Sunny J. Jones, Robert J. Lovelett, Dave A. Rubinow, Rijul Singhal, Celia Charlton, Nadine Piazza, Quinn Hauck, Nikhil Sharma, Paul A. Muller
Enteric neurons (ENs) are interwoven into the gastrointestinal (GI) tract, where they integrate local and external information to coordinate gut function across diverse cell types. Since EN dysfunction underlies the pathophysiology of multiple GI diseases, targeting relevant EN populations presents a multifaceted therapeutic approach. Despite their importance in essential physiologies, ENs remain underexplored from a transcriptional, circuit-based, and functional perspective. To enable target identification and validation in drug discovery, we leveraged a suite of modern neuroscience tools and profiled ENs. Single-nuclei sequencing, chemogenetics, circuit tracing, and pharmacology resolved how EN populations can modulate GI motility, secretion, food intake, and inflammation. We then determined the extent of conservation between mouse and human EN subsets. This work provides disease-relevant insights into EN cell type- and region-specific functions, lays the methodological groundwork to further probe EN function in vivo, and highlights translational hurdles and opportunities between mouse and human.
{"title":"In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons","authors":"Claire J. Millett, James J. Shaver, Bernadette Bracken, Sunny J. Jones, Robert J. Lovelett, Dave A. Rubinow, Rijul Singhal, Celia Charlton, Nadine Piazza, Quinn Hauck, Nikhil Sharma, Paul A. Muller","doi":"10.1016/j.cell.2025.11.024","DOIUrl":"https://doi.org/10.1016/j.cell.2025.11.024","url":null,"abstract":"Enteric neurons (ENs) are interwoven into the gastrointestinal (GI) tract, where they integrate local and external information to coordinate gut function across diverse cell types. Since EN dysfunction underlies the pathophysiology of multiple GI diseases, targeting relevant EN populations presents a multifaceted therapeutic approach. Despite their importance in essential physiologies, ENs remain underexplored from a transcriptional, circuit-based, and functional perspective. To enable target identification and validation in drug discovery, we leveraged a suite of modern neuroscience tools and profiled ENs. Single-nuclei sequencing, chemogenetics, circuit tracing, and pharmacology resolved how EN populations can modulate GI motility, secretion, food intake, and inflammation. We then determined the extent of conservation between mouse and human EN subsets. This work provides disease-relevant insights into EN cell type- and region-specific functions, lays the methodological groundwork to further probe EN function <em>in vivo</em>, and highlights translational hurdles and opportunities between mouse and human.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"56 27 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11Epub Date: 2025-10-24DOI: 10.1016/j.cell.2025.10.004
Tian Lu, Yuting Xie, Yingrui Wang, Xiling Lin, Xue Cai, Yuqi Zhang, Zongxiang Nie, Chang Su, Wanglong Gou, Hong Zhang, Jing Wang, Yan Zhong, Zeyin Lai, Jingjing Xiang, Peng-Fei Shan, Ju-Sheng Zheng, Huijun Wang, Yi Zhu, Tiannan Guo
Population aging is accelerating, yet the multi-organ aging process and the geroprotective effects of dietary protein restriction (PR) remain poorly understood. Here, we conducted comprehensive proteomic analyses on 41 mouse tissues during male mouse aging and PR. Our findings identified tissue-specific aging hallmarks, including widespread changes in immunoglobulins and serine protease inhibitors across multiple tissues. PR mitigated age-related tissue-specific protein expression, epigenomic states, and protein phosphorylation patterns, and it significantly improved adipose tissue functions. These findings were supported by independent reduced representation bisulfite sequencing (RRBS), phosphoproteomics, and pathological analyses. Furthermore, analysis of plasma samples from mice and humans confirmed the cardiovascular benefits of PR. We identified sexual and temporal variations in the impact of PR, with middle age being the optimal intervention period. Overall, our study depicts the multi-organ aging process and provides valuable insights into the geroprotective potential of PR.
{"title":"Protein restriction reprograms the multi-organ proteomic landscape of mouse aging.","authors":"Tian Lu, Yuting Xie, Yingrui Wang, Xiling Lin, Xue Cai, Yuqi Zhang, Zongxiang Nie, Chang Su, Wanglong Gou, Hong Zhang, Jing Wang, Yan Zhong, Zeyin Lai, Jingjing Xiang, Peng-Fei Shan, Ju-Sheng Zheng, Huijun Wang, Yi Zhu, Tiannan Guo","doi":"10.1016/j.cell.2025.10.004","DOIUrl":"10.1016/j.cell.2025.10.004","url":null,"abstract":"<p><p>Population aging is accelerating, yet the multi-organ aging process and the geroprotective effects of dietary protein restriction (PR) remain poorly understood. Here, we conducted comprehensive proteomic analyses on 41 mouse tissues during male mouse aging and PR. Our findings identified tissue-specific aging hallmarks, including widespread changes in immunoglobulins and serine protease inhibitors across multiple tissues. PR mitigated age-related tissue-specific protein expression, epigenomic states, and protein phosphorylation patterns, and it significantly improved adipose tissue functions. These findings were supported by independent reduced representation bisulfite sequencing (RRBS), phosphoproteomics, and pathological analyses. Furthermore, analysis of plasma samples from mice and humans confirmed the cardiovascular benefits of PR. We identified sexual and temporal variations in the impact of PR, with middle age being the optimal intervention period. Overall, our study depicts the multi-organ aging process and provides valuable insights into the geroprotective potential of PR.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"7309-7326.e20"},"PeriodicalIF":42.5,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：