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Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells. Piperlongumine通过ROS诱导增强奥沙利铂对癌症细胞的抗肿瘤作用
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-12-01 Epub Date: 2019-09-06 DOI: 10.1007/s13402-019-00471-x
Peichen Zhang, Lingyan Shi, Tingting Zhang, Lin Hong, Wei He, Peihai Cao, Xin Shen, Peisen Zheng, Yiqun Xia, Peng Zou

Purpose: Oxaliplatin is one of the most commonly used chemotherapeutic agents in the treatment of various cancers, including gastric cancer. It has, however, a narrow therapeutic index due to its toxicity and the occurrence of drug resistance. Therefore, there is a pressing need to develop novel therapies to potentiate the efficacy and reduce the toxicity of oxaliplatin. Piperlongumine (PL), an alkaloid isolated from Piper longum L., has recently been identified as a potent agent against cancer cells in vitro and in vivo. In the present study, we investigated whether PL can potentiate the antitumor effect of oxaliplatin in gastric cancer cells.

Methods: Cellular apoptosis and ROS levels were analyzed by flow cytometry. Thioredoxin reductase 1 (TrxR1) activity in gastric cancer cells or tumor tissues was determined using an endpoint insulin reduction assay. Western blotting was used to analyze the expression levels of the indicated proteins. Nude mice xenograft models were used to test the effects of PL and oxaliplatin combinations on gastric cancer cell growth in vivo.

Results: We found that PL significantly enhanced oxaliplatin-induced growth inhibition in both gastric and colon cancer cells. Moreover, we found that PL potentiated the antitumor effect of oxaliplatin by inhibiting TrxR1 activity. PL combined with oxaliplatin markedly suppressed the activity of TrxR1, resulting in the accumulation of ROS and, thereby, DNA damage induction and p38 and JNK signaling pathway activation. Pretreatment with antioxidant N-acetyl-L-cysteine (NAC) significantly abrogated the combined treatment-induced ROS generation, DNA damage and apoptosis. Importantly, we found that activation of the p38 and JNK signaling pathways prompted by PL and oxaliplatin was also reversed by NAC pretreatment. In vivo, we found that PL combined with oxaliplatin significantly suppressed tumor growth in a gastric cancer xenograft model, and effectively reduced the activity of TrxR1 in tumor tissues. Remarkably, we found that PL attenuated body weight loss evoked by oxaliplatin treatment.

Conclusions: Our data support a synergistic effect of PL and oxaliplatin and suggest that application of its combination may be more effective for the treatment of gastric cancer than oxaliplatin alone.

目的:奥沙利铂是治疗包括胃癌在内的各种癌症最常用的化疗药物之一。然而,由于其毒性和耐药性的出现,它的治疗指数较窄。因此,迫切需要开发新型疗法来增强奥沙利铂的疗效并降低其毒性。胡椒龙葵碱(Piperlongumine,PL)是从胡椒龙葵(Piper longum L.)中分离出来的一种生物碱,最近被确认为体外和体内抗癌细胞的有效药物。在本研究中,我们探讨了PL能否增强奥沙利铂对胃癌细胞的抗肿瘤作用:方法:采用流式细胞术分析细胞凋亡和 ROS 水平。采用终点胰岛素还原试验测定胃癌细胞或肿瘤组织中硫氧还原酶 1 (TrxR1) 的活性。用 Western 印迹法分析所述蛋白质的表达水平。裸鼠异种移植模型用于检测 PL 和奥沙利铂组合对胃癌细胞体内生长的影响:结果:我们发现 PL 能明显增强奥沙利铂诱导的胃癌和结肠癌细胞的生长抑制作用。此外,我们还发现 PL 通过抑制 TrxR1 的活性增强了奥沙利铂的抗肿瘤作用。PL与奥沙利铂联合使用可明显抑制TrxR1的活性,导致ROS积累,从而诱发DNA损伤,激活p38和JNK信号通路。使用抗氧化剂 N-乙酰-L-半胱氨酸(NAC)进行预处理可显著减少联合治疗诱导的 ROS 生成、DNA 损伤和细胞凋亡。重要的是,我们发现 NAC 预处理还能逆转 PL 和奥沙利铂对 p38 和 JNK 信号通路的激活。在体内,我们发现 PL 联合奥沙利铂能显著抑制胃癌异种移植模型中的肿瘤生长,并有效降低肿瘤组织中 TrxR1 的活性。值得注意的是,我们发现 PL 能减轻奥沙利铂治疗引起的体重下降:我们的数据支持 PL 和奥沙利铂的协同作用,并表明联合应用 PL 和奥沙利铂治疗胃癌可能比单独应用奥沙利铂更有效。
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引用次数: 40
Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN. 过表达microRNA-34a的人骨髓间充质干细胞分泌外泌体通过下调MYCN改善胶质母细胞瘤的发展。
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-12-01 Epub Date: 2019-07-22 DOI: 10.1007/s13402-019-00461-z
Bin Wang, Zhong-Hua Wu, Ping-Yang Lou, Chang Chai, Shuang-Yin Han, Jian-Fang Ning, Ming Li

Purpose: Exosomes play important roles in intercellular communication through signaling pathways affecting tumor microenvironment modulation and tumor proliferation, including those in glioblastoma (GBM). As yet, however, limited studies have been conducted on the inhibitory effect of human bone marrow-derived mesenchymal stem cell (hBMSC)-derived exosomes on GBM development. Therefore, we set out to assess the role of hBMSC secreted exosomes, in particular those carrying microRNA-34a (miR-34a), in the development of GBM.

Methods: Microarray-based expression analysis was employed to identify differentially expressed genes and to predict miRNAs regulating MYCN expression. Next, hBMSCs were transfected with a miR-34a mimic or inhibitor after which exosomes were isolated. Proliferation, apoptosis, migration, invasion and temozolomide (TMZ) chemosensitivity of exosome-exposed GBM cells (T-98G, LN229 and A-172) were measured in vitro. The mechanism underlying MYCN regulation was investigated using lentiviral transfections. The in vivo inhibitory effect of exosomal miR-34a was measured in nude mice xenografted with GBM cells through subcutaneous injection of hBMSCs with an upregulated miR34a content.

Results: We found that poorly-expressed miR-34a specifically targeted and negatively regulated the expression of MYCN in GBM cells. In addition we found that miR-34a was delivered to T-98G, LN229 and A-172 GBM cells via hBMSC-derived exosomes. Exogenous overexpression of miR-34a in hBMSC-derived exosomes resulted in inhibition of GBM cell proliferation, invasion, migration and tumorigenesis in vitro and in vivo, while promoting the chemosensitivity of GBM cells to TMZ by silencing MYCN.

Conclusions: From our data we conclude that hBMSC-derived exosomes overexpressing miR-34a may be instrumental for the therapeutic targeting and clinical management of GBM.

目的:外泌体通过影响肿瘤微环境调节和肿瘤增殖的信号通路在细胞间通讯中发挥重要作用,包括在胶质母细胞瘤(GBM)中。然而,迄今为止,关于人骨髓间充质干细胞(hBMSC)来源的外泌体对GBM发育的抑制作用的研究还很有限。因此,我们开始评估hBMSC分泌外泌体,特别是那些携带microRNA-34a (miR-34a)的外泌体在GBM发展中的作用。方法:采用微阵列表达分析鉴定差异表达基因,预测调节MYCN表达的mirna。接下来,用miR-34a模拟物或抑制剂转染hBMSCs,然后分离外泌体。体外检测外泌体暴露的GBM细胞(T-98G、LN229和A-172)的增殖、凋亡、迁移、侵袭及替莫唑胺(TMZ)的化学敏感性。利用慢病毒转染研究了MYCN调控的机制。通过皮下注射miR34a含量上调的hBMSCs,在移植GBM细胞的裸鼠中测量了外泌体miR-34a的体内抑制作用。结果:我们发现低表达的miR-34a特异性靶向并负向调节GBM细胞中MYCN的表达。此外,我们发现miR-34a通过hbmsc衍生的外泌体递送到T-98G、LN229和A-172 GBM细胞。在hbmsc来源的外泌体中外源性过表达miR-34a导致GBM细胞体外和体内增殖、侵袭、迁移和肿瘤发生受到抑制,同时通过沉默MYCN促进GBM细胞对TMZ的化学敏感性。结论:根据我们的数据,我们得出结论,hbmsc衍生的过表达miR-34a的外泌体可能有助于GBM的治疗靶向和临床管理。
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引用次数: 26
Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210 来自吉西他滨耐药胰腺癌干细胞的外泌体通过递送miR-210增强耐药
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-11-12 DOI: 10.1007/s13402-019-00476-6
Zhiyong Yang, Ning Zhao, J. Cui, Heshui Wu, J. Xiong, T. Peng
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引用次数: 108
The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism Xc−抑制剂柳氮磺吡啶通过谷胱甘肽依赖性机制改善药理学维生素C对前列腺癌症细胞的抗癌作用
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-10-15 DOI: 10.1007/s13402-019-00474-8
Zi-Heng Zheng, Gan-hua Luo, Xinchong Shi, Yali Long, Wanqing Shen, Zhoulei Li, Xiangsong Zhang
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引用次数: 18
PRMT1 promotes pancreatic cancer growth and predicts poor prognosis PRMT1促进胰腺癌生长并预测不良预后
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-09-13 DOI: 10.1007/s13402-019-00435-1
Chao Song, Tianwei Chen, Lan He, Ning Ma, Jian-ang Li, Y. Rong, Yuan Fang, Mengmeng Liu, D. Xie, W. Lou
{"title":"PRMT1 promotes pancreatic cancer growth and predicts poor prognosis","authors":"Chao Song, Tianwei Chen, Lan He, Ning Ma, Jian-ang Li, Y. Rong, Yuan Fang, Mengmeng Liu, D. Xie, W. Lou","doi":"10.1007/s13402-019-00435-1","DOIUrl":"https://doi.org/10.1007/s13402-019-00435-1","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"43 1","pages":"51 - 62"},"PeriodicalIF":6.6,"publicationDate":"2019-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13402-019-00435-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52880035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma 四跨膜蛋白CD81介导人骨肉瘤的生长和转移
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-09-07 DOI: 10.1007/s13402-019-00472-w
N. Mizoshiri, T. Shirai, R. Terauchi, S. Tsuchida, Y. Mori, Daichi Hayashi, T. Kishida, Y. Arai, O. Mazda, T. Nakanishi, T. Kubo
{"title":"The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma","authors":"N. Mizoshiri, T. Shirai, R. Terauchi, S. Tsuchida, Y. Mori, Daichi Hayashi, T. Kishida, Y. Arai, O. Mazda, T. Nakanishi, T. Kubo","doi":"10.1007/s13402-019-00472-w","DOIUrl":"https://doi.org/10.1007/s13402-019-00472-w","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"42 1","pages":"861 - 871"},"PeriodicalIF":6.6,"publicationDate":"2019-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13402-019-00472-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43622790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation 14-3-3θ与AF4的串扰增强MLL-AF4活性并促进白血病细胞增殖
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-09-06 DOI: 10.1007/s13402-019-00468-6
Tiziana Fioretti, Armando Cevenini, Mariateresa Zanobio, M. Raia, Daniela Sarnataro, F. Salvatore, G. Esposito
{"title":"Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation","authors":"Tiziana Fioretti, Armando Cevenini, Mariateresa Zanobio, M. Raia, Daniela Sarnataro, F. Salvatore, G. Esposito","doi":"10.1007/s13402-019-00468-6","DOIUrl":"https://doi.org/10.1007/s13402-019-00468-6","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"42 1","pages":"829 - 845"},"PeriodicalIF":6.6,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13402-019-00468-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46576541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Epigenetics of lung cancer: a translational perspective 肺癌的表观遗传学:一个翻译的观点
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-08-08 DOI: 10.1007/s13402-019-00465-9
Á. Quintanal-Villalonga, S. Molina-Pinelo
{"title":"Epigenetics of lung cancer: a translational perspective","authors":"Á. Quintanal-Villalonga, S. Molina-Pinelo","doi":"10.1007/s13402-019-00465-9","DOIUrl":"https://doi.org/10.1007/s13402-019-00465-9","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"42 1","pages":"739 - 756"},"PeriodicalIF":6.6,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13402-019-00465-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45665050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Tumor dormancy as an alternative step in the development of chemoresistance and metastasis - clinical implications 肿瘤休眠作为化疗耐药和转移发展的一个替代步骤-临床意义
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-08-07 DOI: 10.1007/s13402-019-00467-7
Federico Rossari, Cristina Zucchinetti, G. Buda, E. Orciuolo
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引用次数: 34
Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment 异硫氰酸苯乙酯通过靶向her2阳性乳腺癌和卵巢癌的干细胞室阻碍其生长和进展
IF 6.6 2区 医学 Q1 Medicine Pub Date : 2019-08-02 DOI: 10.1007/s13402-019-00464-w
Ada Koschorke, S. Faraci, Debora Giani, C. Chiodoni, E. Iorio, R. Canese, M. Colombo, A. Lamolinara, M. Iezzi, M. Ladomery, Claudio Vernieri, F. de Braud, M. Di Nicola, E. Tagliabue, L. Castagnoli, S. Pupa
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引用次数: 13
期刊
Cellular Oncology
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