Pub Date : 2024-06-28DOI: 10.31635/ccschem.024.202403977
CCS Chemistry, Ahead of Print.
CCS Chemistry, Ahead of Print.
{"title":"One-Step Ethylene Purification from a Seven-Component Cracking Gas Mixture with Sorbent-Sorbate Induced-Fit","authors":"","doi":"10.31635/ccschem.024.202403977","DOIUrl":"https://doi.org/10.31635/ccschem.024.202403977","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"12 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-27DOI: 10.31635/ccschem.024.202404169
CCS Chemistry, Ahead of Print.
CCS Chemistry, Ahead of Print.
{"title":"Cooperative Communication Between the Active Sites and Surrounding Environments in a Supported Ag4Pt2(SR)8 Cluster on Carbon Black","authors":"","doi":"10.31635/ccschem.024.202404169","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404169","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"24 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-27DOI: 10.31635/ccschem.024.202404335
CCS Chemistry, Ahead of Print.
CCS Chemistry, Ahead of Print.
{"title":"Cu-Catalyzed Asymmetric Hydrogermylation Towards C- and Ge-Stereogenic Germanes","authors":"","doi":"10.31635/ccschem.024.202404335","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404335","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"87 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.31635/ccschem.024.202404276
Sijia Chen, Lin Li, Yunqing Gu, Fang Luo, Kunyu Chen, Yan Lou, Quan Huang, Jingjing Hu, Yiyun Cheng
Supramolecular hydrogels demonstrate considerable potential in drug delivery owing to their distinctive features, including bio-adhesiveness, self-healing behaviors, biodegradability, and biocompatibility. Nevertheless, the fabrication of supramolecular hydrogels utilizing exclusively clinically approved drugs remain challenging, typically necessitating chemical modifications of the drugs to facilitate the gelation process. In this study, we report a novel type of supramolecular hydrogel through the direct assembly of two clinically approved drugs, tobramycin and mycophenolic acid, via combined electrostatic and hydrophobic interactions. The hydrogel shows adjustable bio-adhesiveness, zero-order release kinetics, good biocompatibility, and maintained antibacterial and immunosuppressive activities. It efficiently inhibits bacterial infections and foreign body responses, and accelerates tissue healing in several subcutaneous/intraosseous implantation models accompanied by bacteria infections. This work provides a facile and promising strategy to fabricate supramolecular hydrogels with stable drug release kinetics using clinically approved drugs.
{"title":"A Supramolecular Bifunctional Hydrogel with Zero-Order Release Kinetics to Resist Bacterial Infection and Foreign Body Response of Implants","authors":"Sijia Chen, Lin Li, Yunqing Gu, Fang Luo, Kunyu Chen, Yan Lou, Quan Huang, Jingjing Hu, Yiyun Cheng","doi":"10.31635/ccschem.024.202404276","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404276","url":null,"abstract":"<p>Supramolecular hydrogels demonstrate considerable potential in drug delivery owing to their distinctive features, including bio-adhesiveness, self-healing behaviors, biodegradability, and biocompatibility. Nevertheless, the fabrication of supramolecular hydrogels utilizing exclusively clinically approved drugs remain challenging, typically necessitating chemical modifications of the drugs to facilitate the gelation process. In this study, we report a novel type of supramolecular hydrogel through the direct assembly of two clinically approved drugs, tobramycin and mycophenolic acid, via combined electrostatic and hydrophobic interactions. The hydrogel shows adjustable bio-adhesiveness, zero-order release kinetics, good biocompatibility, and maintained antibacterial and immunosuppressive activities. It efficiently inhibits bacterial infections and foreign body responses, and accelerates tissue healing in several subcutaneous/intraosseous implantation models accompanied by bacteria infections. This work provides a facile and promising strategy to fabricate supramolecular hydrogels with stable drug release kinetics using clinically approved drugs.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"32 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25DOI: 10.31635/ccschem.024.202404231
CCS Chemistry, Ahead of Print.
CCS Chemistry, Ahead of Print.
{"title":"Cobalt-Catalyzed Asymmetric Synthesis of Planar Chiral Ferrocene Derivatives via C(sp2)–C(sp3) Bond Formation","authors":"","doi":"10.31635/ccschem.024.202404231","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404231","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"10 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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