The electronic and optical properties of the newly synthesized molybdenum dinitride (MoN2) in the hypothetical 2H structure analogous to MoS2 is investigated using the density functional theory (DFT) full potential linearized augmented plane wave (FP-LAPW) method and the modified Becke–Johnson (mBJ) approximation. The aim is to investigate the optoelectronic properties of this compound for potential optical sensing applications and compare with the capabilities of MoS2 in this field. As compared to MoS2, which is a semiconductor, MoN2 is found to be a semi metal from the band structure plots. The dielectric function, optical conductivity and the optical constants, namely, the refractive index, the reflectivity, the extinction and absorption coefficients, are evaluated and compared with those of MoS2 and discussed with reference to the sensing performance.
{"title":"First Principles Investigation of the Optoelectronic Properties of Molybdenum Dinitride for Optical Sensing Applications","authors":"A. Ramanathan","doi":"10.3390/csac2021-10429","DOIUrl":"https://doi.org/10.3390/csac2021-10429","url":null,"abstract":"The electronic and optical properties of the newly synthesized molybdenum dinitride (MoN2) in the hypothetical 2H structure analogous to MoS2 is investigated using the density functional theory (DFT) full potential linearized augmented plane wave (FP-LAPW) method and the modified Becke–Johnson (mBJ) approximation. The aim is to investigate the optoelectronic properties of this compound for potential optical sensing applications and compare with the capabilities of MoS2 in this field. As compared to MoS2, which is a semiconductor, MoN2 is found to be a semi metal from the band structure plots. The dielectric function, optical conductivity and the optical constants, namely, the refractive index, the reflectivity, the extinction and absorption coefficients, are evaluated and compared with those of MoS2 and discussed with reference to the sensing performance.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76542436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Tobolska, N. E. Wezynfeld, Urszula E. Wawrzyniak, W. Bal, W. Wróblewski
Amyloid-β (Aβ) peptides are crucial in the pathology of Alzheimer’s disease. On the other hand, their metal complexes possess distinctive coordination properties that could be of great importance in the selective recognition of (bio)analytes, such as anions. Here, we report a novel group of molecular receptors for phosphate anions recognition: metal–peptide complexes of Aβ peptides, which combine features of synthetic inorganic ligands and naturally occurring binding proteins. The influence of the change in the metal ion center on the coordination and redox properties of binary Cu(II)/Ni(II)-Aβ complexes, as well as the affinity of these complexes towards phosphate species, were analyzed. This approach offers the possibility of fine-tuning the receptor affinity for desired applications.
淀粉样蛋白-β (Aβ)肽在阿尔茨海默病的病理中起着至关重要的作用。另一方面，它们的金属配合物具有独特的配位特性，这在(生物)分析物(如阴离子)的选择性识别中非常重要。在这里，我们报道了一组新的磷酸阴离子识别分子受体:a β肽的金属肽复合物，它结合了合成无机配体和天然存在的结合蛋白的特征。分析了金属离子中心的变化对Cu(II)/Ni(II)- a - β二元配合物配位和氧化还原性能的影响，以及这些配合物对磷酸盐的亲和力。这种方法提供了微调所需应用的受体亲和力的可能性。
{"title":"Metal–Peptide Complexes—A Novel Class of Molecular Receptors for Electrochemical Phosphate Sensing","authors":"Aleksandra Tobolska, N. E. Wezynfeld, Urszula E. Wawrzyniak, W. Bal, W. Wróblewski","doi":"10.3390/csac2021-10449","DOIUrl":"https://doi.org/10.3390/csac2021-10449","url":null,"abstract":"Amyloid-β (Aβ) peptides are crucial in the pathology of Alzheimer’s disease. On the other hand, their metal complexes possess distinctive coordination properties that could be of great importance in the selective recognition of (bio)analytes, such as anions. Here, we report a novel group of molecular receptors for phosphate anions recognition: metal–peptide complexes of Aβ peptides, which combine features of synthetic inorganic ligands and naturally occurring binding proteins. The influence of the change in the metal ion center on the coordination and redox properties of binary Cu(II)/Ni(II)-Aβ complexes, as well as the affinity of these complexes towards phosphate species, were analyzed. This approach offers the possibility of fine-tuning the receptor affinity for desired applications.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80001468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amer Charbaji, H. Heidari-Bafroui, Nasim Rahmani, C. Anagnostopoulos, M. Faghri
Paper-based microfluidic technology is a relatively new field of research that provides low-cost platforms and sensors for point-of-care diagnostics. While the majority of research in this field has been for biomedical applications, more and more paper-based devices and platforms are being designed and developed for environmental applications, such as water quality monitoring and assessment. One such application is the detection of nitrate in water samples. Colorimetric detection of nitrate by paper-based devices using the Griess assay requires the reduction of nitrate to nitrite before undergoing the reaction. In this paper, we measured the performance of a paper-based dip strip for detecting nitrate and nitrite by calculating its limit of detection and limit of quantification. We also calculated the reduction efficiency of vanadium (III) chloride in the dip strip for detecting nitrate. Our results show that the reduction time of nitrate via vanadium (III) chloride is much longer than that when using zinc microparticles. Our results also show that the performance of the dip strip using vanadium (III) chloride for nitrate detection is not as good as more intricate paper-based devices that have a separate reaction zone with zinc microparticles. The limits of detection and quantification calculated were 3.352 and 7.437 ppm, and the nitrate reduction efficiency varied over the range of nitrate concentrations tested.
{"title":"Colorimetric Determination of Nitrate after Reduction to Nitrite in a Paper-Based Dip Strip","authors":"Amer Charbaji, H. Heidari-Bafroui, Nasim Rahmani, C. Anagnostopoulos, M. Faghri","doi":"10.3390/csac2021-10459","DOIUrl":"https://doi.org/10.3390/csac2021-10459","url":null,"abstract":"Paper-based microfluidic technology is a relatively new field of research that provides low-cost platforms and sensors for point-of-care diagnostics. While the majority of research in this field has been for biomedical applications, more and more paper-based devices and platforms are being designed and developed for environmental applications, such as water quality monitoring and assessment. One such application is the detection of nitrate in water samples. Colorimetric detection of nitrate by paper-based devices using the Griess assay requires the reduction of nitrate to nitrite before undergoing the reaction. In this paper, we measured the performance of a paper-based dip strip for detecting nitrate and nitrite by calculating its limit of detection and limit of quantification. We also calculated the reduction efficiency of vanadium (III) chloride in the dip strip for detecting nitrate. Our results show that the reduction time of nitrate via vanadium (III) chloride is much longer than that when using zinc microparticles. Our results also show that the performance of the dip strip using vanadium (III) chloride for nitrate detection is not as good as more intricate paper-based devices that have a separate reaction zone with zinc microparticles. The limits of detection and quantification calculated were 3.352 and 7.437 ppm, and the nitrate reduction efficiency varied over the range of nitrate concentrations tested.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87589531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The inner core system of metal-free (‘free base’) porphyrins has continually served as a ligand for various metal ions, but it was only recently studied in organocatalysis due its highly tunable basicity. Highly conjugated porphyrin systems offer spectrophotometric sensitivity toward geometrical and/or electronic changes and, thus, utilizing the porphyrin core for the selective detection of substrates in solution offers significant potential for a multitude of applications. However, solvation and dilution drastically affect weak interactions by dispersing the binding agent to its surroundings. Thus, the spectroscopic detection of N–H···X-type binding in porphyrin solutions is almost impossible without especially designing the binding pocket. Here, we present the first report on the spectroscopic detection of N–H···X-type interplay in porphyrins formed by weak interactions. Protonated 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-aminophenyl) porphyrin contains coordination sites for the selective binding of charge-bearing analytes, revealing characteristic spectroscopic responses. While electronic absorption spectroscopy proved to be a particularly useful tool for the detection of porphyrin–analyte interactions in the supramolecular complexes, X-ray crystallography helped to pinpoint the orientation, flexibility, and encapsulation of substrates in the corresponding atropisomers. This charge-assisted complexation of analytes in the anion-selective porphyrin inner core system is ideal for the study of atropisomers using high-resolution NMR, since it reduces the proton exchange rate, generating static proton signals. Therefore, we were able to characterize all four rotamers of the nonplanar 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-aminophenyl) porphyrin by performing 1D and 2D NMR spectroscopic analyses of host-guest systems consisting of benzenesulfonic acid (BSA) and each porphyrin atropisomer. Lastly, a detailed assignment of the symmetry operations that are unique to porphyrin atropisomers allowed us to accurately identify the rotamers using NMR techniques only. Overall, the N–H···X-type interplay in porphyrins formed by weak interactions that form restricted H-bonding complexes is shown to be the key to unravelling the atropisomeric enigma.
{"title":"Core Modulation of Porphyrins for Chemical Sensing","authors":"Karolis Norvaiša, M. Senge","doi":"10.3390/csac2021-10417","DOIUrl":"https://doi.org/10.3390/csac2021-10417","url":null,"abstract":"The inner core system of metal-free (‘free base’) porphyrins has continually served as a ligand for various metal ions, but it was only recently studied in organocatalysis due its highly tunable basicity. Highly conjugated porphyrin systems offer spectrophotometric sensitivity toward geometrical and/or electronic changes and, thus, utilizing the porphyrin core for the selective detection of substrates in solution offers significant potential for a multitude of applications. However, solvation and dilution drastically affect weak interactions by dispersing the binding agent to its surroundings. Thus, the spectroscopic detection of N–H···X-type binding in porphyrin solutions is almost impossible without especially designing the binding pocket. Here, we present the first report on the spectroscopic detection of N–H···X-type interplay in porphyrins formed by weak interactions. Protonated 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-aminophenyl) porphyrin contains coordination sites for the selective binding of charge-bearing analytes, revealing characteristic spectroscopic responses. While electronic absorption spectroscopy proved to be a particularly useful tool for the detection of porphyrin–analyte interactions in the supramolecular complexes, X-ray crystallography helped to pinpoint the orientation, flexibility, and encapsulation of substrates in the corresponding atropisomers. This charge-assisted complexation of analytes in the anion-selective porphyrin inner core system is ideal for the study of atropisomers using high-resolution NMR, since it reduces the proton exchange rate, generating static proton signals. Therefore, we were able to characterize all four rotamers of the nonplanar 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-aminophenyl) porphyrin by performing 1D and 2D NMR spectroscopic analyses of host-guest systems consisting of benzenesulfonic acid (BSA) and each porphyrin atropisomer. Lastly, a detailed assignment of the symmetry operations that are unique to porphyrin atropisomers allowed us to accurately identify the rotamers using NMR techniques only. Overall, the N–H···X-type interplay in porphyrins formed by weak interactions that form restricted H-bonding complexes is shown to be the key to unravelling the atropisomeric enigma.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88737291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mycotoxins are the toxic secondary metabolites naturally produced by fungi; their contamination in agricultural products and food severely threatens food safety and public health worldwide. The reliable, efficient, and sensitive quantification of mycotoxins in food has become increasingly challenging to tackle due to the complexity of food matrices and their low level. Visual detection has emerged as a popular trend toward miniaturization and simplification of mycotoxins assays yet is constrained with their limited sensitivity. This review mainly focuses on the various sensitive visual immunoassays for signal amplified detection of mycotoxins. These signal amplified immunoassays for the improved sensitivity of mycotoxins detection in food through nanomaterials for encapsulation enzyme, enzyme-mediated nanomaterials as the amplified signal readout, and nanozyme. Furthermore, the underlying principle and the advantages of visual immunoassays for mycotoxins have been proposed. And the challenges and perspectives have been proposed to develop improved efficient visual immunoassays for mycotoxins in food.
{"title":"Advances in Visual Immunoassays for Sensitive Detection of Mycotoxins in Food—A Review","authors":"Meijuan Liang, Qi Zhang, Peiwu Li","doi":"10.3390/csac2021-10443","DOIUrl":"https://doi.org/10.3390/csac2021-10443","url":null,"abstract":"Mycotoxins are the toxic secondary metabolites naturally produced by fungi; their contamination in agricultural products and food severely threatens food safety and public health worldwide. The reliable, efficient, and sensitive quantification of mycotoxins in food has become increasingly challenging to tackle due to the complexity of food matrices and their low level. Visual detection has emerged as a popular trend toward miniaturization and simplification of mycotoxins assays yet is constrained with their limited sensitivity. This review mainly focuses on the various sensitive visual immunoassays for signal amplified detection of mycotoxins. These signal amplified immunoassays for the improved sensitivity of mycotoxins detection in food through nanomaterials for encapsulation enzyme, enzyme-mediated nanomaterials as the amplified signal readout, and nanozyme. Furthermore, the underlying principle and the advantages of visual immunoassays for mycotoxins have been proposed. And the challenges and perspectives have been proposed to develop improved efficient visual immunoassays for mycotoxins in food.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87064062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Fernández, J. Bastos-Arrieta, C. Palet, M. Baeza
Many carbon materials are well-known conductive materials, widely used in the fabrication of composite electrodes. In this work, diverse allotropic forms of carbon such as graphite, MWCNTs and rGO were tested. Furthermore, these materials allow the construction of cheaper, smaller, portable, reliable and easy-to-use devices, which can be easily modified. The above-mentioned composite electrodes were developed for metal analysis in water such as Cu, Cd and Pb that, at a high concentration, can have consequences on human health. SWASV is the selected technique. It would be ideal to exploit the potential properties of mercury for metal detection by tuning the electrode’s surface. Due to mercury’s hazardous properties and to reduce the amount of this substance used in polarography, the use of nanoparticles is a good option due to their properties. Mercury nanoparticles were used to modify the surface of the composite electrodes to improve electroanalytical sensor response. For this reason, using these modified composite electrodes can lower detection limits and widen the linear range that can be achieved for Cd (0.05–1 mg·L−1) and Pb (0.045–1 mg·L−1). However, for Cu (0.114–1.14 mg·L−1), meaningful variations were not observed compared to the bare electrode.
{"title":"Tunable Electrochemical Sensors Based on Carbon Nanocomposite Materials towards Enhanced Determination of Cadmium, Lead and Copper in Water","authors":"L. Fernández, J. Bastos-Arrieta, C. Palet, M. Baeza","doi":"10.3390/csac2021-10456","DOIUrl":"https://doi.org/10.3390/csac2021-10456","url":null,"abstract":"Many carbon materials are well-known conductive materials, widely used in the fabrication of composite electrodes. In this work, diverse allotropic forms of carbon such as graphite, MWCNTs and rGO were tested. Furthermore, these materials allow the construction of cheaper, smaller, portable, reliable and easy-to-use devices, which can be easily modified. The above-mentioned composite electrodes were developed for metal analysis in water such as Cu, Cd and Pb that, at a high concentration, can have consequences on human health. SWASV is the selected technique. It would be ideal to exploit the potential properties of mercury for metal detection by tuning the electrode’s surface. Due to mercury’s hazardous properties and to reduce the amount of this substance used in polarography, the use of nanoparticles is a good option due to their properties. Mercury nanoparticles were used to modify the surface of the composite electrodes to improve electroanalytical sensor response. For this reason, using these modified composite electrodes can lower detection limits and widen the linear range that can be achieved for Cd (0.05–1 mg·L−1) and Pb (0.045–1 mg·L−1). However, for Cu (0.114–1.14 mg·L−1), meaningful variations were not observed compared to the bare electrode.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78945416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, a variety of semiconducting oxides were prepared and principally characterized by means of spectroscopic techniques (absorbance FT-IR, diffuse reflectance UV-Vis-NIR) to shed light on the electronic properties and defects involved at the roots of gas sensing capabilities. The thick films were obtained by screen printing technology on which electrical characterization and gas sensing measurements were performed. From the cross analysis of the results, a description of the specific sensing mechanism for each material is proposed.
{"title":"Semiconductor Oxide Gas Sensors: Correlation between Conduction Mechanisms and Their Sensing Performances","authors":"A. Fioravanti, S. Morandi, M. Carotta","doi":"10.3390/csac2021-10472","DOIUrl":"https://doi.org/10.3390/csac2021-10472","url":null,"abstract":"In this work, a variety of semiconducting oxides were prepared and principally characterized by means of spectroscopic techniques (absorbance FT-IR, diffuse reflectance UV-Vis-NIR) to shed light on the electronic properties and defects involved at the roots of gas sensing capabilities. The thick films were obtained by screen printing technology on which electrical characterization and gas sensing measurements were performed. From the cross analysis of the results, a description of the specific sensing mechanism for each material is proposed.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90593143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Lazarova, S. Bozhilova, S. Ivanova, D. Christova, T. Babeva
Organic solvents are widely used as reaction media and/or for the separation and purification of synthetic products in chemical and pharmaceutical industries [...]
有机溶剂在化学和制药工业中广泛用作反应介质和/或用于合成产品的分离和纯化[…]
{"title":"Optical Characterization of Acetone-Sensitive Thin Films of poly(vinyl alcohol)-g-poly(methyl acrylate)","authors":"K. Lazarova, S. Bozhilova, S. Ivanova, D. Christova, T. Babeva","doi":"10.3390/csac2021-10416","DOIUrl":"https://doi.org/10.3390/csac2021-10416","url":null,"abstract":"Organic solvents are widely used as reaction media and/or for the separation and purification of synthetic products in chemical and pharmaceutical industries [...]","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76043208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Torres-Méndez, Jayendra Ellamathy, M. Mascarenhas, Yifan Liu, Georgia-Vasiliki Gkountana, Patrizia Kühne, Javier Sebastián, I. Jovanović, David Bern, Sharmilee Nandi, Maike Lüftner, Viktoria Langwallner, Maria Lysandrou, S. Taylor, Klara Martinovic, A. Atif, E. Manouchehri, M. Kamali-Moghaddam, G. Mestres
Influenza A virus belongs to the Orthomyxoviridae family and, to date, is one of the most important pathogens causing acute respiratory infections, such as the recent pandemic of 2009. Hemagglutinin (HA) is one of the surface proteins of the virus that allow it to interact with cellular molecules. Due to the fact that it is the most abundant protein in the virus capsule, it is the best target in the detection of the Influenza A H1N1 virus through biosensing devices. Our aim is to develop an electrochemical biosensor to detect H1 by modifying carbon screen-printed electrodes (CSPE) with gold nanoparticles and to add further functionalization with monoclonal antibodies that are specific to this protein. The electrodes were characterized by the means of cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Our preliminary results suggest that the selected monoclonal antibodies have acceptable affinity and bind effectively to the H1 protein and that the electrodes have a wide potential window in the presence of [Fe(CN)6]3−/4−. In the future, we will continue to develop this biosensor in hope that it will be commercialized and be common in medical procedures during flu seasons and future influenza pandemics.
{"title":"Developing an Electrochemical Biosensor for the Detection of Hemagglutinin Protein of Influenza A Virus Subtype H1N1 in Artificial Saliva","authors":"C. Torres-Méndez, Jayendra Ellamathy, M. Mascarenhas, Yifan Liu, Georgia-Vasiliki Gkountana, Patrizia Kühne, Javier Sebastián, I. Jovanović, David Bern, Sharmilee Nandi, Maike Lüftner, Viktoria Langwallner, Maria Lysandrou, S. Taylor, Klara Martinovic, A. Atif, E. Manouchehri, M. Kamali-Moghaddam, G. Mestres","doi":"10.3390/csac2021-10477","DOIUrl":"https://doi.org/10.3390/csac2021-10477","url":null,"abstract":"Influenza A virus belongs to the Orthomyxoviridae family and, to date, is one of the most important pathogens causing acute respiratory infections, such as the recent pandemic of 2009. Hemagglutinin (HA) is one of the surface proteins of the virus that allow it to interact with cellular molecules. Due to the fact that it is the most abundant protein in the virus capsule, it is the best target in the detection of the Influenza A H1N1 virus through biosensing devices. Our aim is to develop an electrochemical biosensor to detect H1 by modifying carbon screen-printed electrodes (CSPE) with gold nanoparticles and to add further functionalization with monoclonal antibodies that are specific to this protein. The electrodes were characterized by the means of cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Our preliminary results suggest that the selected monoclonal antibodies have acceptable affinity and bind effectively to the H1 protein and that the electrodes have a wide potential window in the presence of [Fe(CN)6]3−/4−. In the future, we will continue to develop this biosensor in hope that it will be commercialized and be common in medical procedures during flu seasons and future influenza pandemics.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77495031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Moufid, C. Tiebe, N. El Bari, M. Bartholmai, B. Bouchikhi
In this study, the ability of an electronic nose developed to analyze and monitor odor emissions from three poultry farms located in Meknes (Morocco) and Berlin (Germany) was evaluated. Indeed, the potentiality of the electronic nose (e-nose) to differentiate the concentration fractions of hydrogen sulfide, ammonia, and ethanol was investigated. Furthermore, the impact change of relative humidity values (from 15% to 67%) on the responses of the gas sensors was reported and revealed that the effect remained less than 0.6%. Furthermore, the relevant results confirmed that the developed e-nose system was able to perfectly classify and monitor the odorous air of poultry farms.
{"title":"Characterization of Unpleasant Odors in Poultry Houses Using Metal Oxide Semiconductor-Based Gas Sensor Arrays and Pattern Recognition Methods","authors":"M. Moufid, C. Tiebe, N. El Bari, M. Bartholmai, B. Bouchikhi","doi":"10.3390/csac2021-10481","DOIUrl":"https://doi.org/10.3390/csac2021-10481","url":null,"abstract":"In this study, the ability of an electronic nose developed to analyze and monitor odor emissions from three poultry farms located in Meknes (Morocco) and Berlin (Germany) was evaluated. Indeed, the potentiality of the electronic nose (e-nose) to differentiate the concentration fractions of hydrogen sulfide, ammonia, and ethanol was investigated. Furthermore, the impact change of relative humidity values (from 15% to 67%) on the responses of the gas sensors was reported and revealed that the effect remained less than 0.6%. Furthermore, the relevant results confirmed that the developed e-nose system was able to perfectly classify and monitor the odorous air of poultry farms.","PeriodicalId":9815,"journal":{"name":"Chemistry Proceedings","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75417327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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