Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/10399d
T. Makharadze, G. Makharadzé
Fulvic acids play an important role in complicated formation processes and determine how heavy metals migrate in natural waterways. Despite investigation, experimental data on the stability constants of complex fulvic acid-heavy metal complexes (including nickel) is heterogeneous and differs in various ways from one another. One of the sources of this problem is the failure to consider the average molecular weight of fulvic acid partners, which leads to incorrect results. The solubility method was used to investigate the complex formation process between Ni (II) and fulvic acids at pH=8.0. The suspension of Ni(OH)2 was used as a solid phase. The adsorption–chromatographic approach was used to separate fulvic acids from Paravani Lake. The active charcoal was used as a sorbent. In this chapter is shown that, during complex formation process every 0,29 part of an associate of fulvic acids(Mw=6260), inculcates into nickel’s inner coordination sphere as an integral ligand, so it may assume, that the average molecular weight of the associate of fulvic acids which takes part in complex formation process equals to 1815. This component of the fulvic acid association was previously referred to as a "active associate.".The average molecular weight of the “active associate” was used for determination the composition of nickel dyhydroxo fulvate complex (1:1), the concentration of free ligand and average stability constant, which equals to (beta) = 7,95x105; lg (beta)=5,90
{"title":"The Calculation of the Stability Constant of Nickel Fulvate, using an Average Molecular Weight of Active Associate of Fulvic Acids at pH = 8","authors":"T. Makharadze, G. Makharadzé","doi":"10.9734/bpi/cacs/v4/10399d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/10399d","url":null,"abstract":"Fulvic acids play an important role in complicated formation processes and determine how heavy metals migrate in natural waterways. Despite investigation, experimental data on the stability constants of complex fulvic acid-heavy metal complexes (including nickel) is heterogeneous and differs in various ways from one another. One of the sources of this problem is the failure to consider the average molecular weight of fulvic acid partners, which leads to incorrect results. The solubility method was used to investigate the complex formation process between Ni (II) and fulvic acids at pH=8.0. The suspension of Ni(OH)2 was used as a solid phase. The adsorption–chromatographic approach was used to separate fulvic acids from Paravani Lake. The active charcoal was used as a sorbent. In this chapter is shown that, during complex formation process every 0,29 part of an associate of fulvic acids(Mw=6260), inculcates into nickel’s inner coordination sphere as an integral ligand, so it may assume, that the average molecular weight of the associate of fulvic acids which takes part in complex formation process equals to 1815. This component of the fulvic acid association was previously referred to as a \"active associate.\".The average molecular weight of the “active associate” was used for determination the composition of nickel dyhydroxo fulvate complex (1:1), the concentration of free ligand and average stability constant, which equals to (beta) = 7,95x105; lg (beta)=5,90","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73332932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/9843d
J. Rashid, M. Barakat, M. Alghamdi
The use of a strong anion exchange resin (Spectra/Gel IE 1x8) as an adsorbent for the efficient removal of Cr(VI) ions from synthetic wastewater solutions has been studied.Initial Cr(VI) ions concentrations in batch tests ranged from 25 to 300 mg/L. Various factors impacting Cr(VI) adsorption, such as solution pH, Cr(VI) and adsorbent concentrations, and contact time, were investigated. The results showed that Cr(VI) was successfully retained by the resin. For initial Cr(VI) concentrations up to 100 mg/L, equilibrium was reached in 30 minutes. The equilibrium data for adsorption of Cr(VI) was fitted with both Langmuir and Freundlich isotherms, however, the Langmuir isotherm model was shown to be more suitable for Cr(VI) adsorption, with a maximum adsorption capacity of 173.8 mg/g. The adsorption process followed second order kinetics. After three regeneration cycles, the resin was regenerated with 4M NaOH as an eluent and retained a Cr(VI) adsorption effectiveness of more than 83%.
{"title":"Research on Adsorption of Chromium (VI) from Wastewater by Anion Exchange Resin","authors":"J. Rashid, M. Barakat, M. Alghamdi","doi":"10.9734/bpi/cacs/v4/9843d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/9843d","url":null,"abstract":"The use of a strong anion exchange resin (Spectra/Gel IE 1x8) as an adsorbent for the efficient removal of Cr(VI) ions from synthetic wastewater solutions has been studied.Initial Cr(VI) ions concentrations in batch tests ranged from 25 to 300 mg/L. Various factors impacting Cr(VI) adsorption, such as solution pH, Cr(VI) and adsorbent concentrations, and contact time, were investigated. The results showed that Cr(VI) was successfully retained by the resin. For initial Cr(VI) concentrations up to 100 mg/L, equilibrium was reached in 30 minutes. The equilibrium data for adsorption of Cr(VI) was fitted with both Langmuir and Freundlich isotherms, however, the Langmuir isotherm model was shown to be more suitable for Cr(VI) adsorption, with a maximum adsorption capacity of 173.8 mg/g. The adsorption process followed second order kinetics. After three regeneration cycles, the resin was regenerated with 4M NaOH as an eluent and retained a Cr(VI) adsorption effectiveness of more than 83%.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"56 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90208317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/11821d
N. Galushkin, N. Yazvinskaya, D. Galushkin
Thermal runaway occurs in batteries of almost all electrochemical systems. The system housing the battery will inevitably fail in the event of thermal runaway. The purpose of the paper is to establish a thermal runaway mechanism in sealed nickel-cadmium batteries. The paper analyzed a number of experimental facts that prove that the generally accepted point of view on thermal runaway in nickel-cadmium batteries is incorrect. The emergence of a significant exothermic reaction, namely recombination reactions of atomic hydrogen accumulating in the electrodes, is shown to be connected with thermal runaway. Thermal runaway is found to occur ten times less intensively in sealed nickel-cadmium batteries than in unpressurized batteries.
{"title":"Determination of Thermal Runaway in Sealed Nickel-Cadmium Batteries","authors":"N. Galushkin, N. Yazvinskaya, D. Galushkin","doi":"10.9734/bpi/cacs/v4/11821d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/11821d","url":null,"abstract":"Thermal runaway occurs in batteries of almost all electrochemical systems. The system housing the battery will inevitably fail in the event of thermal runaway. The purpose of the paper is to establish a thermal runaway mechanism in sealed nickel-cadmium batteries. The paper analyzed a number of experimental facts that prove that the generally accepted point of view on thermal runaway in nickel-cadmium batteries is incorrect. The emergence of a significant exothermic reaction, namely recombination reactions of atomic hydrogen accumulating in the electrodes, is shown to be connected with thermal runaway. Thermal runaway is found to occur ten times less intensively in sealed nickel-cadmium batteries than in unpressurized batteries.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82938400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/3157f
A. Faheim
In this chapter, synthesis, characterization and applications of ternary complexes are reported. Synthesis of ternary complexes in presence of co-ligand (secondary ligand) with one or two donor atoms is included. Some amino acids, picolinic acid, 8-hydroxyquinoline, 1,10-phenanthroline, dimethylsulphoxide, triphenylphosphie and pyridine are used in preparation of the ternary complexes as representative examples of NN, NO, S, P and N donor ligands. A considerable attention is paid to the application of these ternary complexes in DNA binding and cleavage study. Also, using these ternary complexes as inhibitor for enzyme and to catalyze some reactions is discussed to provide an insight of the wide applications of these complexes in various fields.
{"title":"Study on Synthesis, Characterization and Applications of Ternary Metal Complexes","authors":"A. Faheim","doi":"10.9734/bpi/cacs/v4/3157f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/3157f","url":null,"abstract":"In this chapter, synthesis, characterization and applications of ternary complexes are reported. Synthesis of ternary complexes in presence of co-ligand (secondary ligand) with one or two donor atoms is included. Some amino acids, picolinic acid, 8-hydroxyquinoline, 1,10-phenanthroline, dimethylsulphoxide, triphenylphosphie and pyridine are used in preparation of the ternary complexes as representative examples of NN, NO, S, P and N donor ligands. A considerable attention is paid to the application of these ternary complexes in DNA binding and cleavage study. Also, using these ternary complexes as inhibitor for enzyme and to catalyze some reactions is discussed to provide an insight of the wide applications of these complexes in various fields.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78974148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/3873f
Yadav Dilip, Janwadkar Suhas, Rana Paritosh
A new Analytical reagent, Acetophenone 2’, 4’- dihydroxy semicarbazone [A24DHS] is proposed as a spectrophotometric reagent for U(VI). The reagent A24DHS is synthesized in the laboratory and characterized by NMR, IR and elemental analysis. Spectrophotometric method is presented for the trace determination of U(VI) using A24DHS as spectrophotometric reagent ((lambda)max = 340 nm) in acidic aqueous solution (pH = 7.4). The Beer’s law is obeyed in the concentration range from 1 to 10 ppm. The A24DHS forms a 1:2 coloured complex. The Sandell’s Sensitivity is 0.0823 (mu)g cm-2 with molar absorptivity 2896.43 L mol-1 cm -1. The proposed method has been successfully applied to the determination of Uranium in ores and commercial samples. The precision and the accuracy obtained were satisfactory for its use in the concerned industry. This chapter details the method development for determination of Uranium in different commercial samples.
提出了一种新的分析试剂:苯乙酮2′，4′-二羟基氨基脲[A24DHS]作为U(VI)的分光光度试剂。在实验室合成了A24DHS试剂，并用核磁共振、红外和元素分析对其进行了表征。建立了在pH = 7.4的酸性水溶液中，以A24DHS为分光光度剂((lambda) max = 340 nm)分光光度法测定微量U(VI)的方法。在1 - 10ppm的浓度范围内，遵循比尔定律。A24DHS形成1:2的有色复合体。桑德尔灵敏度为0.0823 (mu) g cm-2，摩尔吸光度为2896.43 L mol-1 cm -1。该方法已成功地应用于矿石和商业样品中铀的测定。所得到的精密度和准确度均满足相关行业的要求。本章详细介绍了测定不同商业样品中铀的方法发展。
{"title":"Study on Spectrophotometric Determination of Uranium in Ore and Commercial Samples","authors":"Yadav Dilip, Janwadkar Suhas, Rana Paritosh","doi":"10.9734/bpi/cacs/v4/3873f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/3873f","url":null,"abstract":"A new Analytical reagent, Acetophenone 2’, 4’- dihydroxy semicarbazone [A24DHS] is proposed as a spectrophotometric reagent for U(VI). The reagent A24DHS is synthesized in the laboratory and characterized by NMR, IR and elemental analysis. Spectrophotometric method is presented for the trace determination of U(VI) using A24DHS as spectrophotometric reagent ((lambda)max = 340 nm) in acidic aqueous solution (pH = 7.4). The Beer’s law is obeyed in the concentration range from 1 to 10 ppm. The A24DHS forms a 1:2 coloured complex. The Sandell’s Sensitivity is 0.0823 (mu)g cm-2 with molar absorptivity 2896.43 L mol-1 cm -1. The proposed method has been successfully applied to the determination of Uranium in ores and commercial samples. The precision and the accuracy obtained were satisfactory for its use in the concerned industry. This chapter details the method development for determination of Uranium in different commercial samples.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74970340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/12139d
Ragni N. Vora, A. Joshi, N. Joshi
The use of plant-based phytochemicals in general synthesis and nano-phytomedicine engineering is a collaboration between plant science and nanotechnology that provides an intrinsically green approach to nanotechnology known as green nanotechnology. The goal of this study is to green synthesise gold nanoparticles from different concentrations of Mucuna monosperma seed extract and characterise them using scanning electron microscopy (SEM), UV-Visible spectrophotometer, and Fourier transform infrared (FTIR) spectroscopy. Mucuna monosperma is a large climbing shrub from family Fabaceae. The gold nanoparticles made with 4% seed extract exhibited good stability when compared to other concentrations. The surface properties of gold nanoparticles were studied using analytical tools such as FTIR, UV-Visible spectrophotometer, and SEM.The produced gold nanoparticles have a spherical form and can be coated with L-DOPA from plants. This opens the door to a wide range of uses, including a vital role in novel drug delivery system (NDDS).
{"title":"Green Synthesis of L-DOPA Coated Gold Nanoparticles from a Natural Source","authors":"Ragni N. Vora, A. Joshi, N. Joshi","doi":"10.9734/bpi/cacs/v4/12139d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/12139d","url":null,"abstract":"The use of plant-based phytochemicals in general synthesis and nano-phytomedicine engineering is a collaboration between plant science and nanotechnology that provides an intrinsically green approach to nanotechnology known as green nanotechnology. The goal of this study is to green synthesise gold nanoparticles from different concentrations of Mucuna monosperma seed extract and characterise them using scanning electron microscopy (SEM), UV-Visible spectrophotometer, and Fourier transform infrared (FTIR) spectroscopy. Mucuna monosperma is a large climbing shrub from family Fabaceae. The gold nanoparticles made with 4% seed extract exhibited good stability when compared to other concentrations. The surface properties of gold nanoparticles were studied using analytical tools such as FTIR, UV-Visible spectrophotometer, and SEM.The produced gold nanoparticles have a spherical form and can be coated with L-DOPA from plants. This opens the door to a wide range of uses, including a vital role in novel drug delivery system (NDDS).","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85959964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/12295d
K. Raja
We have blended 2,6-bis(chlorosubstitutedphenyl)- 3,5-dimethyldihydro-2H-pyran-4(3H)- one by blending of 2-/4-chlorobenzaldehyde, 3-pentanone and potassium hydroxide within the sight of ethanol. The consummation of response has been explored by tender loving care. The mixed combinations structures are insisted by FT-IR, 1H and 13C NMR extraordinary methodology. Further, the arranged combinations were presented to DFT focuses by using B3LYP system with 6-311++G(d,p) premise sets. The improved nuclear properties were connected with precious stone data available recorded as a hard copy. The theoretical results show that the gem configuration can be rehashed by improved math and the vibrational frequencies show incredible simultaneousness with the preliminary regards. The atomic attractive reverberation (NMR) substance shift of the molecule has been dictated by the action self-governing atomic orbital (GIAO) procedure and differentiated and preliminary outcomes. HOMO–LUMO, and other related nuclear and electronic properties are resolved. The Mulliken and NLO charges have moreover been resolved and interpreted.
{"title":"A Detailed Computational Investigation on the Structural and Spectroscopic Properties of Some Pyran Compounds","authors":"K. Raja","doi":"10.9734/bpi/cacs/v4/12295d","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/12295d","url":null,"abstract":"We have blended 2,6-bis(chlorosubstitutedphenyl)- 3,5-dimethyldihydro-2H-pyran-4(3H)- one by blending of 2-/4-chlorobenzaldehyde, 3-pentanone and potassium hydroxide within the sight of ethanol. The consummation of response has been explored by tender loving care. The mixed combinations structures are insisted by FT-IR, 1H and 13C NMR extraordinary methodology. Further, the arranged combinations were presented to DFT focuses by using B3LYP system with 6-311++G(d,p) premise sets. The improved nuclear properties were connected with precious stone data available recorded as a hard copy. The theoretical results show that the gem configuration can be rehashed by improved math and the vibrational frequencies show incredible simultaneousness with the preliminary regards. The atomic attractive reverberation (NMR) substance shift of the molecule has been dictated by the action self-governing atomic orbital (GIAO) procedure and differentiated and preliminary outcomes. HOMO–LUMO, and other related nuclear and electronic properties are resolved. The Mulliken and NLO charges have moreover been resolved and interpreted.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88481325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/2371f
B. Petukhov
A model of the dynamic interaction of dislocations with the impurity subsystem of crystals that have a high lattice potential relief (Peierls barriers) has been developed. Such materials include metals with a body-centered cubic structure, semiconductors, and many others. The constructed theory of the dynamic interaction of dislocations with the impurity subsystem of the crystal takes into account the inverse effect of impurities entrained by moving dislocations on the dynamics of the dislocations themselves. It is justified that the impurity kinetics during atmosphere formation includes two stages. The first (initial) stage is fast and substantially nonequilibrium; it is followed by the second stage, characterized by a slower approach to equilibrium. The initial stage manifests itself at a sufficiently fast dislocation motion and may lead to an anomalous increase in the driving force (or the yield strength of the material) with an increase in the temperature in some range. The consequences of the self-consistent nature of the process are the occurrence of instability of the movement of dislocations in a certain speed range and immobilization of dislocations at stresses with values below a certain threshold. Blocking of the dislocation motion by impurities may cause inverse brittle–ductile transition, which is observed in some materials with an increase (rather than the usual decrease) in temperature.
{"title":"Dynamic Aging of Dislocations in Materials with a High Crystalline Relief: Competition of Diffusion and Dragging Impurities","authors":"B. Petukhov","doi":"10.9734/bpi/cacs/v4/2371f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/2371f","url":null,"abstract":"A model of the dynamic interaction of dislocations with the impurity subsystem of crystals that have a high lattice potential relief (Peierls barriers) has been developed. Such materials include metals with a body-centered cubic structure, semiconductors, and many others. The constructed theory of the dynamic interaction of dislocations with the impurity subsystem of the crystal takes into account the inverse effect of impurities entrained by moving dislocations on the dynamics of the dislocations themselves. It is justified that the impurity kinetics during atmosphere formation includes two stages. The first (initial) stage is fast and substantially nonequilibrium; it is followed by the second stage, characterized by a slower approach to equilibrium. The initial stage manifests itself at a sufficiently fast dislocation motion and may lead to an anomalous increase in the driving force (or the yield strength of the material) with an increase in the temperature in some range. The consequences of the self-consistent nature of the process are the occurrence of instability of the movement of dislocations in a certain speed range and immobilization of dislocations at stresses with values below a certain threshold. Blocking of the dislocation motion by impurities may cause inverse brittle–ductile transition, which is observed in some materials with an increase (rather than the usual decrease) in temperature.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78243301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/2182f
Gadapa Nirupa, U. Tripathi
A novel rapid HPLC method was developed for simultaneous determination of montelukast and doxofylline in bulk and pharmaceutical dosage forms. Development of an analytical method for simultaneous estimation of drugs requires a lot of efforts and of course it is a challenging task. The method was developed by using C18 (150 mm × 4.6 mm, 5 (mu)(mu)m) column; mobile phase consisting of methanol and phosphate buffer at pH 4.5; the flow rate of 1.0 mL/min and ultraviolet detection at 280 nm. Both drugs were sufficiently resolved having retention time of 4.7 min and 1.9 min for montelukast and doxofylline, respectively. The method was validated as per ICH Guidelines for various parameters like precision, linearity, accuracy, ruggedness, and robustness. The validated method was applied to the commercially available pharmaceutical dosage form and obtained the desired result. It is concluded that this method can be used by the industries and academic institutions for their combination drug estimation, which is fast as well as novel.
建立了同时测定原料药和制剂中孟鲁司特和多索茶碱含量的高效液相色谱方法。开发一种用于药物同时估计的分析方法需要大量的努力，当然这是一项具有挑战性的任务。色谱柱为C18 (150 mm × 4.6 mm, 5 (mu)(mu) m);流动相为甲醇和磷酸盐缓冲液，pH为4.5;流速1.0 mL/min，紫外检测280 nm。孟鲁司特和多索茶碱均能充分溶解，滞留时间分别为4.7 min和1.9 min。该方法按照ICH指南进行了各种参数的验证，如精密度、线性度、准确度、坚固性和鲁棒性。将验证的方法应用于市售药物剂型，得到了期望的结果。结果表明，该方法具有快速、新颖的特点，可用于产业界和学术机构的联合用药评价。
{"title":"Development and Validation of a Novel LC Method for the Simultaneous Determination of Montelukast and Doxofylline in Bulk and Pharmaceutical Dosage Forms","authors":"Gadapa Nirupa, U. Tripathi","doi":"10.9734/bpi/cacs/v4/2182f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/2182f","url":null,"abstract":"A novel rapid HPLC method was developed for simultaneous determination of montelukast and doxofylline in bulk and pharmaceutical dosage forms. Development of an analytical method for simultaneous estimation of drugs requires a lot of efforts and of course it is a challenging task. The method was developed by using C18 (150 mm × 4.6 mm, 5 (mu)(mu)m) column; mobile phase consisting of methanol and phosphate buffer at pH 4.5; the flow rate of 1.0 mL/min and ultraviolet detection at 280 nm. Both drugs were sufficiently resolved having retention time of 4.7 min and 1.9 min for montelukast and doxofylline, respectively. The method was validated as per ICH Guidelines for various parameters like precision, linearity, accuracy, ruggedness, and robustness. The validated method was applied to the commercially available pharmaceutical dosage form and obtained the desired result. It is concluded that this method can be used by the industries and academic institutions for their combination drug estimation, which is fast as well as novel.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76881262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-07DOI: 10.9734/bpi/cacs/v4/3691f
K. Tharini
Weight loss experiments, electrochemical methods, and SEM studies in 1M hydrochloric acid (HCl) medium against mild steel (MS) were used to evaluate the corrosion inhibiting ability of a synthetic heterocyclic compound, namely 1, 3, 5-trimethyl-2, 6-diphenyl piperidin-4-one oxime (TPO). The weight loss trials were carried out at three distinct temperatures: 30°C, 40°C, and 50°C for two hours at varied concentrations (0, 25, 50, 100, 200, and 300 ppm).The study discovered that increasing TPO concentration had a positive link with inhibition efficiency while raising temperature had a negative correlation.TPO physically adsorbs on mild steel surfaces, following Temkin’s isotherm. Tafel plot was used to determine electrochemical parameters such as corrosion potential (Ecorr), corrosion current (icorr), and Tafel slopes (ba & bc). TPO significantly reduces corrosion current and acts as a mixed mode inhibitor, according to the findings. The charge transfer resistance (Rct) and double layer capacitance (Cdl) were calculated using the AC impedance measurement determined by the Nyquist plot, whose results complimented each other. TPO's ability to form films in HCl medium was revealed by SEM studies. The values of Rct increase with increase of TPO concentration showed TPO as good inhibitor.
{"title":"Determining the Effect of 1, 3, 5-trimethyl-2, 6-diphenyl Piperidin-4-one Oxime on the Electrochemical Behaviour of Mild Steel in HCl Medium","authors":"K. Tharini","doi":"10.9734/bpi/cacs/v4/3691f","DOIUrl":"https://doi.org/10.9734/bpi/cacs/v4/3691f","url":null,"abstract":"Weight loss experiments, electrochemical methods, and SEM studies in 1M hydrochloric acid (HCl) medium against mild steel (MS) were used to evaluate the corrosion inhibiting ability of a synthetic heterocyclic compound, namely 1, 3, 5-trimethyl-2, 6-diphenyl piperidin-4-one oxime (TPO). The weight loss trials were carried out at three distinct temperatures: 30°C, 40°C, and 50°C for two hours at varied concentrations (0, 25, 50, 100, 200, and 300 ppm).The study discovered that increasing TPO concentration had a positive link with inhibition efficiency while raising temperature had a negative correlation.TPO physically adsorbs on mild steel surfaces, following Temkin’s isotherm. Tafel plot was used to determine electrochemical parameters such as corrosion potential (Ecorr), corrosion current (icorr), and Tafel slopes (ba & bc). TPO significantly reduces corrosion current and acts as a mixed mode inhibitor, according to the findings. The charge transfer resistance (Rct) and double layer capacitance (Cdl) were calculated using the AC impedance measurement determined by the Nyquist plot, whose results complimented each other. TPO's ability to form films in HCl medium was revealed by SEM studies. The values of Rct increase with increase of TPO concentration showed TPO as good inhibitor.","PeriodicalId":9826,"journal":{"name":"Challenges and Advances in Chemical Science Vol. 4","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83013867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：