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The association of chronotype, sleep duration and trajectories of health-risk behaviors among college students: a cohort study. 大学生的时间型、睡眠时间与健康风险行为轨迹的关系:一项队列研究。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2025-01-27 DOI: 10.1186/s13034-025-00861-0
Wanyu Che, Chenfang Wang, Shuman Tao, Tingting Li, Yang Xie, Fangbiao Tao, Xiaoyan Wu

Purpose: To describe the trajectories of health-risk behaviors (HRBs) among college students through four consecutive surveys and explore the relationship between chronotype, sleep duration and different trajectories of HRBs.

Methods: We used a data sample of 1,042 college students from the College Student Behavior and Health Cohort Study. Students reported sleep parameters, including chronotype (Morningness-Eveningness Questionnaire-5, MEQ-5) and sleep duration. The behavior scale was used to evaluate four HRBs (smoking, alcohol use, low physical activity, smartphone addiction). The latent class growth analysis (LCGA) was used to estimate the trajectory of self-reported HRBs. Multivariate logistic regression models were used to study whether sleep parameters (chronotype and sleep duration) correlated with HRBs' trajectories.

Results: Four unique trajectories of behaviors were identified: unhealthy group (7.4%), increasing group (21.3%), decreasing group (10.3%) and healthy group (61.0%). Compared with the normal sleep, results from logistic regression analyses indicated that long sleep (> 9 h) was associated with the decreasing group and the unhealthy group (P < 0.05), while short sleep (< 7 h) was associated with the increasing group and the unhealthy group (P < 0.05). Compared with the M-type, the E-type were positively correlated with the unhealthy group, the increasing group, and the decreasing group (P < 0.05).

Conclusion: E-type, short sleep duration and long sleep duration were significantly associated with the trajectory of HRBs. Findings underscore the need for targeted screening and prevention of modifiable sleep behaviors with the aim of improving HRBs in college students.

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引用次数: 0
The effects of training female students in emotion regulation techniques on their social problem-solving skills and social anxiety: a randomized controlled trial.
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2025-01-22 DOI: 10.1186/s13034-025-00860-1
Ashraf Akbari, Camellia Torabizadeh, Narjes Nick, Giti Setoodeh, Parvin Ghaemmaghami

Background: Social anxiety is one of the most prevalent anxiety-related disorders among adolescents with many adverse effects on the social and academic lives of this population. In addition, poor social problem-solving skills can aggravate anxiety in individuals suffering from anxiety. Emotion regulation can help adolescents control and moderate their feelings, thereby enabling them to understand their emotions better, cope with their negative emotions in a positive way, and adopt a more realistic approach to solving their problems. The objective of the present study is to investigate the effects of educating female students in emotion regulation techniques on their social problem-solving skills and social anxiety.

Method: This study was a randomized controlled trial conducted in Iran, utilizing a pretest-posttest design with control and intervention groups. The subjects were 47 female high-school second graders who were randomly divided into a control (25 students) and an intervention group (22 students). The intervention group was collectively educated in emotion regulation techniques in weekly one-hour sessions for eight weeks. The control group did not receive any intervention. The social anxiety and social problem-solving scales were completed by both groups before, immediately after, and one month after the intervention. The collected data were analyzed in SPSS v. 22 and level of significance was set at p < 0.05.

Result: Data analysis of the intervention group compared to the control group demonstrated that group training in emotional regulation techniques effectively increased social problem-solving skills scores (p = 0.003) and decreased social anxiety scores (p < 0.0001) among students in the intervention group compared to their pretest scores. These effects remained stable during the follow-up phase.

Conclusion: In view of the prevalence of social anxiety among adolescents, it is suggested that the policymakers and administrators in the education system promote emotion regulation skills in adolescent students to facilitate their psychological adaptation and improve their emotional capabilities.

Trial registration: The present study was registered under the code IRCT20220413054521N1 (Registration date: 27/02/2024) in the Iranian Registry of Clinical Trials.

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引用次数: 0
Mental health in children with and without ADHD: the role of physical activity and parental nativity. 有和没有多动症儿童的心理健康:身体活动和父母出生的作用。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2025-01-18 DOI: 10.1186/s13034-025-00859-8
David Adzrago, Saanie Sulley, Faustine Williams

Background: Physical activity (PA) can improve mental health, including anxiety/depression, in individuals with attention-deficit/hyperactivity disorder (ADHD) with minimal side effects, unlike pharmacotherapy that can result in significant side effects. However, the influence of PA on mental health among children with ADHD is understudied. Also, immigrants tend to have better mental health, but the influence of parental nativity on children's mental health is unknown. We examined the relationship between PA, parental nativity, and current anxiety/depression among U.S. children with and without ADHD. We also analyzed whether ADHD diagnosis status moderates the relationship between anxiety/depression and PA or parental nativity.

Methods: We used national annual cross-sectional data from the 2016 to 2021 National Survey of Children's Health to conduct weighted multivariable logistic regression and moderation analyses, with current anxiety/depression status as the outcome variable. The sampling involves selecting households with children and rostering children in the household from each state and the District of Columbia. A parent or caregiver of the selected child completes the surveys. We restricted the analysis to children aged 6-17 years (N = 140,977).

Results: The prevalence of current anxiety/depression was higher in children with ADHD diagnosis (37.34%) than those without ADHD diagnosis (7.42%). Children with ADHD (versus no ADHD) had higher odds of anxiety/depression. Engaging in PA (versus no PA) and having immigrant parents (versus non-immigrant parents) were associated with lower anxiety/depression odds. ADHD diagnosis status significantly moderated the association between anxiety/depression and PA or parental nativity. However, the three-way interaction between ADHD status, parental nativity, and physical activity was not statistically significant. Stratified by ADHD diagnosis status, those who engaged in PA (versus did not) for 1 to 3 days, 4 to 6 days, and daily were less often diagnosed with anxiety/depression disorder among those with or without ADHD, especially children without ADHD. The odds were also lower for children with or without ADHD whose parents were immigrants than children with non-immigrant parents, particularly children without ADHD who had immigrant parents. Parental nativity did not significantly moderate the association between PA and anxiety/depression among children with and without ADHD.

Conclusions: Physical activity was associated with lower risks of diagnosed with anxiety/depression disorder among children, especially children without ADHD and those with immigrant parents. Considering parental nativity and incorporating personalized PA in ADHD and anxiety/depression management can improve mental illness and ADHD symptoms among children.

背景:体育活动(PA)可以改善心理健康,包括焦虑/抑郁,对患有注意力缺陷/多动障碍(ADHD)的个体,其副作用最小,不像药物治疗可能导致显著的副作用。然而,PA对ADHD儿童心理健康的影响尚未得到充分研究。此外,移民往往有更好的心理健康,但父母出生对儿童心理健康的影响尚不清楚。我们研究了在美国有和没有多动症的儿童中,PA、父母出生和当前焦虑/抑郁之间的关系。我们还分析了ADHD诊断状态是否调节焦虑/抑郁与PA或父母出生的关系。方法:采用2016 - 2021年全国儿童健康调查年度横断面数据,以当前焦虑/抑郁状态为结局变量,进行加权多变量logistic回归和调节分析。抽样包括从每个州和哥伦比亚特区选择有孩子的家庭,并登记家庭中的孩子。被选儿童的父母或照顾者完成调查。我们将分析限制在6-17岁的儿童(N = 140,977)。结果:ADHD患儿当前焦虑/抑郁患病率(37.34%)高于未诊断ADHD患儿(7.42%)。患有多动症的儿童(与没有多动症的儿童相比)有更高的焦虑/抑郁几率。参与私人护理(相对于没有私人护理)和父母是移民(相对于父母不是移民)与较低的焦虑/抑郁几率相关。ADHD诊断状态显著调节焦虑/抑郁与PA或父母出生的关系。然而,ADHD状态、父母出生和身体活动之间的三方相互作用没有统计学意义。根据ADHD诊断状态分层,在有或没有ADHD的儿童中,每天进行1至3天、4至6天和每天进行PA的人(与没有进行的人相比)被诊断为焦虑/抑郁障碍的情况较少,尤其是没有ADHD的儿童。父母是移民的孩子患或不患多动症的几率也比父母是非移民的孩子低,尤其是父母是移民的没有多动症的孩子。在有和没有ADHD的儿童中,父母的出生并没有显著调节PA和焦虑/抑郁之间的关联。结论:体育活动与儿童诊断为焦虑/抑郁障碍的风险较低有关,特别是没有ADHD的儿童和移民父母的儿童。在ADHD和焦虑/抑郁管理中考虑父母的出生并结合个性化的PA可以改善儿童的精神疾病和ADHD症状。
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引用次数: 0
Validity, reliability and clinical utility of ASSIST-Y in assessing risk of substance-related harm and dependence in Spanish male adolescents. ASSIST-Y 评估西班牙男性青少年药物相关伤害和依赖风险的有效性、可靠性和临床实用性。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2025-01-13 DOI: 10.1186/s13034-024-00845-6
Núria Ibáñez-Martínez, Matthew William Richard Stevens, Núria Civit-Bel, Noemí Moreno-Ferrer, Sandra Lopez-Ferré, Ana Olivares-Casado, Juame Claramunt-Mendoza, Chris Holmwood, Robert Ali

Background: Substance use among adolescents is strongly associated with adverse physical, mental health, and social outcomes. Prevention and early intervention can reduce the likelihood of future problems, but requires valid and reliable screening tools capable of assessing risk across a range of substances. This study assessed the validity, reliability, and clinical utility of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST-Y) for adolescents aged 15-17 years.

Methods: A sample of adolescent males (N = 101), aged 15-17 years, held in a juvenile detention facility on substance-related offences in Barcelona, Spain were eligible. Participants were administered a battery of standardized substance-use screening tools by a clinical psychologist, and underwent a diagnostic interview assessing DSM-IV-TR substance abuse and dependence by an addiction medicine specialist. Scores on the various assessments were compared to establish validity (concurrent with interview, convergent with other measures), reliability, and clinical utility of ASSIST-Y.

Results: Majority of participants (n = 77) completed assessments. While tobacco was not assessed as part of the interview, concurrent validity in detecting substance abuse was established for all remaining substances. Concurrent validity for detecting dependence was established for alcohol, cannabis, cocaine, stimulants and sedatives. Fewer numbers in higher-risk groups for inhalants, opioids and hallucinogen use limited confirmation of validity for those substances. ASSIST-Y also demonstrated good convergent validity with the other screening tools for all substances, except hallucinogens. Reliability for each subscale was established, except for tobacco (too few items), sedatives, and hallucinogens. Finally, clinical utility indices were significant for most substances (except sedatives and opioids); whilst clinical utility indices were significant for ruling out cases of non-dependence (all substances).

Conclusions: As a screening tool, the purpose of ASSIST-Y is designed to help identify adolescents who may be at-risk of substance-related harm. While the instrument was found to be valid and reliable in identifying risky use across a variety of substances, further research is needed to validate the instrument in other population groups, and for other substances. Future research should investigate the effect of the linked brief intervention to reduce risk of harm, especially for non-specialist clinicians.

背景:青少年药物使用与不良的身体、心理健康和社会结果密切相关。预防和早期干预可以减少未来出现问题的可能性,但需要有效和可靠的筛选工具,能够评估一系列物质的风险。本研究评估了15-17岁青少年酒精、吸烟和物质介入筛查试验(ASSIST-Y)的效度、信度和临床应用。方法:选取年龄在15-17岁的青少年男性(N = 101)作为样本,他们被关押在西班牙巴塞罗那的一家青少年拘留所,从事与药物有关的犯罪活动。由临床心理学家对参与者进行一系列标准化的药物使用筛选工具,并由成瘾医学专家进行诊断性访谈,评估DSM-IV-TR药物滥用和依赖。对各种评估的得分进行比较,以确定ASSIST-Y的效度(与访谈同时进行,与其他测量相收敛)、可靠性和临床实用性。结果:大多数参与者(n = 77)完成了评估。虽然烟草没有作为面谈的一部分进行评估,但确定了所有其他物质在检测药物滥用方面的同时有效性。建立了检测酒精、大麻、可卡因、兴奋剂和镇静剂依赖性的同时效度。在吸入剂、阿片类药物和致幻剂的高风险群体中,使用这些物质有效性的有限确认的人数较少。ASSIST-Y在除致幻剂外的所有物质中也表现出与其他筛选工具良好的收敛效度。除烟草(项目太少)、镇静剂和致幻剂外,每个分量表都建立了可靠度。最后,大多数药物(镇静剂和阿片类药物除外)的临床效用指数均显著;而临床效用指数对于排除非依赖性病例(所有物质)具有重要意义。结论:作为一种筛查工具,ASSIST-Y的目的是帮助识别可能存在物质相关伤害风险的青少年。虽然发现该工具在识别各种物质的危险使用方面是有效和可靠的,但需要进一步研究以在其他人群和其他物质中验证该工具。未来的研究应该调查相关的短期干预对降低伤害风险的影响,特别是对非专业临床医生。
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引用次数: 0
The relationship between callous-unemotional traits and internalizing psychopathology in adolescent psychiatric inpatients: a network analysis. 青少年精神科住院患者冷酷无情特质与内化精神病理的关系:网络分析。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-27 DOI: 10.1186/s13034-024-00853-6
Laura Maria Derks, Eni Sabine Becker, Wolf-Gero Lange, Mike Rinck, Anna Lena Dapprich, Martin Holtmann, Tanja Legenbauer

Background: Numerous studies have investigated the relevance of callous-unemotional traits in relation to externalizing psychopathology among children and adolescents. However, less research has examined the connections between callous-unemotional traits and internalizing psychopathology and findings were inconsistent. Consequently, the present study aimed to elucidate the role of callous-unemotional traits in the context of depression and anxiety while controlling for conduct problems, age, and gender.

Methods: The study utilized self-report questionnaire data from 978 adolescent psychiatric inpatients (Mage = 15.18, SD = 1.44) presenting a range of psychopathological conditions. A network analysis was conducted, incorporating callous-unemotional traits, depressive symptoms, anxiety symptoms, conduct problems, and covariates (age, gender). Additionally, comparisons were made between the networks of inpatients diagnosed with conduct disorders and those with internalizing disorders.

Results: The findings indicated that callous-unemotional traits were relevant within the general network, as well as in both the conduct disorder and internalizing networks. In both contexts, callous-unemotional traits were predominately positively associated with depression and conduct problems. Within the conduct disorder network, callous-unemotional traits exhibited primarily negative associations with anxiety, whereas the relationships within the internalizing network were more varied.

Conclusions: Our findings suggest that callous-unemotional traits hold substantial relevance for internalizing symptoms, supporting the notion that these traits should be considered potentially transdiagnostic factors.

背景:许多研究调查了儿童和青少年中冷酷无情特征与外化精神病理的相关性。然而,很少有研究调查冷酷无情的性格特征和内化精神病理学之间的联系,研究结果也不一致。因此,本研究旨在阐明在控制行为问题、年龄和性别的情况下,冷酷无情特质在抑郁和焦虑情境中的作用。方法:对978名青少年精神科住院患者(Mage = 15.18, SD = 1.44)进行自我报告问卷调查。进行了网络分析,包括冷酷无情的特征、抑郁症状、焦虑症状、行为问题和协变量(年龄、性别)。此外,还比较了被诊断为行为障碍和内化障碍的住院患者的网络。结果:研究结果表明,冷酷无情特征在一般网络中存在,在品行障碍网络和内化网络中也存在。在这两种情况下,冷酷无情的性格特征与抑郁和行为问题呈正相关。在行为障碍网络中,冷酷无情特征主要与焦虑呈负相关,而内化网络中的关系则更为多样。结论:我们的研究结果表明,冷酷无情的特征与内化症状有很大的相关性,支持这些特征应被视为潜在的跨诊断因素的观点。
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引用次数: 0
Crafting inclusive parenting programs- considerations for deaf families: a qualitative study. 制定包容性的养育计划——对聋人家庭的考虑:一项定性研究。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-19 DOI: 10.1186/s13034-024-00852-7
Asher Emmanuel Ikwara, Rebecca Nabagesera, Isaac Isiko

Background: The parenting of children by deaf parents has many challenges that require a barrier-breaking approach to ensure inclusivity and accessibility. Therefore, this study explored pathways for crafting inclusive parenting programs, fostering a future where every family thrives, regardless of hearing ability.

Methods: This was a qualitative study that employed in-depth interviews with 20 deaf parents and utilized thematic content analysis. This study was carried out at events organized by the Uganda National Association of the Deaf (UNAD) at Makerere College School. Deaf parents were purposively selected from attendees at events organised by the Uganda National Association of the Deaf (UNAD) during the specified celebrations.

Results: An analysis of interviews with deaf parents identified six crucial themes for inclusive parenting programs. Language education was highlighted for strengthening family bonds. Communication and relationship building emphasized equal treatment and love for deaf children. Cultural sensitivity and education were deemed essential, as visual tools and district associations were used. Tailoring content for deaf children emphasized playful and educational materials, such as sign language videos. The utilization of technology for accessible programs and the promotion of community involvement are recognized as critical components.

Conclusion: This study emphasized the unique experiences of deaf parents, highlighting the need for sign language education, cultural sensitivity, and technology while addressing challenges like limited resources, stigma, and advocacy gaps in parenting programs.

背景:聋人父母抚养孩子面临许多挑战,需要一种打破障碍的方法来确保包容性和可及性。因此,本研究探索了制定包容性育儿计划的途径,培养每个家庭都能茁壮成长的未来,而不管听力能力如何。方法:采用质性研究,对20名失聪家长进行深度访谈,并采用主题内容分析法。这项研究是在乌干达全国聋人协会在Makerere学院学校组织的活动中进行的。在指定的庆祝活动中,聋人父母是从乌干达全国聋人协会(UNAD)组织的活动的与会者中有意挑选出来的。结果:对失聪父母访谈的分析确定了包容性育儿计划的六个关键主题。强调语文教育可以加强家庭关系。沟通和关系的建立强调对聋儿的平等对待和关爱。文化敏感性和教育被认为是必不可少的,因为使用了视觉工具和地区协会。为聋哑儿童量身定制的内容强调好玩和有教育意义的材料,比如手语视频。利用技术进行无障碍项目和促进社区参与被认为是关键的组成部分。结论:本研究强调了聋人父母的独特经历,强调了手语教育、文化敏感性和技术的必要性,同时解决了资源有限、污名化和育儿计划宣传差距等挑战。
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引用次数: 0
The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis. 益生菌对自闭症谱系障碍核心症状和相关行为症状的治疗效果:系统综述和荟萃分析。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-19 DOI: 10.1186/s13034-024-00848-3
Jen-Chin Lee, Chia-Min Chen, Cheuk-Kwan Sun, I-Ting Tsai, Yu-Shian Cheng, Hsien-Jane Chiu, Ming Yu Wang, Yen-Hsiang Tang, Kuo-Chuan Hung

Background: We aimed at investigating the efficacies of probiotics in alleviating the core and associated symptoms of autism spectrum disorder (ASD).

Methods: Randomized placebo-controlled trials were identified from major electronic databases from inception to Nov 2023. The outcomes of interests including improvements in the total and associated symptoms of ASD were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95% confidence interval (CI).

Results: Ten studies with 522 participants (mean age = 8.11) were included in this meta-analysis. The primary results revealed significant improvement in total symptoms in the probiotics group compared with the controls (SMD = - 0.19, p = 0.03, ten studies, n = 522) but not the core symptoms (i.e., repetitive restricted behaviors, As affiliations 3 and 5 are same, we have deleted the duplicate affiliations and renumbered accordingly. Please check and confirm.problems with social behaviors/communication). Subgroup analyses demonstrated improvement in total symptoms in probiotics users relative to their controls only in studies using multiple-strain probiotics (SMD = - 0.26, p = 0.03, five studies, n = 288) but not studies using single-strain regimens. Secondary results showed improvement in adaptation (SMD = 0.37, p = 0.03, three studies, n = 139) and an improvement trend in anxiety symptoms in the probiotics group compared with controls (SMD = - 0.29, 95% CI - 0.60 to 0.02, p = 0.07, three studies, n = 163) but failed to demonstrate greater improvement in the former regarding symptoms of irritability/aggression, hyperactivity/impulsivity, inattention, and parental stress.

Conclusions: Our study supported probiotics use against the overall behavioral symptoms of ASD, mainly in individuals receiving multiple-strain probiotics as supplements. However, our results showed that probiotics use was only associated with improvement in adaptation and perhaps anxiety, but not core symptoms, highlighting the impact of adaptation on quality of life rather than just the core symptoms. Nevertheless, the limited number of included trials warrants further large-scale clinical investigations.

背景:我们旨在研究益生菌在缓解自闭症谱系障碍(ASD)核心症状和相关症状方面的疗效。方法:从主要的电子数据库中检索从开始到2023年11月的随机安慰剂对照试验。兴趣结果包括ASD总症状和相关症状的改善,基于标准化平均差(SMD)以95%置信区间(CI)定量表示为效应大小(ES)。结果:10项研究纳入522名参与者(平均年龄8.11岁)。初步结果显示,与对照组相比,益生菌组的总症状有显著改善(SMD = - 0.19, p = 0.03, 10项研究,n = 522),但核心症状(即重复性限制性行为)没有改善。由于隶属关系3和5相同,我们删除了重复的隶属关系并重新编号。请确认。社交行为/沟通问题)。亚组分析显示,只有在使用多菌株益生菌的研究中(SMD = - 0.26, p = 0.03, 5项研究,n = 288),使用单菌株益生菌的研究中,益生菌用户的总症状相对于对照组有所改善。次要结果显示,与对照组相比,益生菌组在适应方面有所改善(SMD = 0.37, p = 0.03, 3项研究,n = 139),焦虑症状有改善趋势(SMD = - 0.29, 95% CI - 0.60 ~ 0.02, p = 0.07, 3项研究,n = 163),但前者在易怒/攻击、多动/冲动、注意力不集中和父母压力等症状方面没有更大改善。结论:我们的研究支持使用益生菌治疗ASD的整体行为症状,主要是在接受多菌株益生菌补充剂的个体中。然而,我们的研究结果显示,益生菌的使用只与适应和焦虑的改善有关,而与核心症状无关,这突出了适应对生活质量的影响,而不仅仅是核心症状。然而,有限数量的纳入试验需要进一步的大规模临床研究。
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引用次数: 0
Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials. 大麻素治疗青少年精神疾病:随机对照试验的系统综述。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-18 DOI: 10.1186/s13034-024-00846-5
Patrick Köck, Andrzej Badek, Maximilian Meyer, Arndt-Lukas Klaassen, Marc Walter, Jochen Kindler

Background: Cannabinoids have been of increasing interest mainly due to their putative efficacy in a wide array of psychiatric, psychosomatic, and neurological conditions.

Aims: This systematic review aims to synthesize results from randomized placebo-controlled trials regarding the efficacy and the dosage of cannabinoids as therapeutics in psychiatric disorders in children, adolescents, and young adults.

Methods: All publications up to June 30th, 2024, were included from PubMed and Embase. Eligibility criteria in accordance with the PRISMA-guidelines was applied. RCTs providing pre- and post-treatment parameters on cannabinoid therapies for mental disorders in comparison to controls in an age range from 0 to 25 years were included. Effect sizes were calculated as Hedges' g for primary outcomes, and a multilevel random-effects meta-analysis was conducted to account for dependent outcomes from same study populations.

Results: We identified 7603 records, of which 8 independent clinical trials (reported in 9 publications) met the pre-established eligibility criteria, comprising 474 unique participants (245 treatment, 229 control). Analysis of 13 primary outcomes (of 7 clinical trials) revealed a modest positive overall effect for symptom improvement or normalization of brain physiology (Hedges' g = 0.308, 95% CI: 0.167, 0.448). Autism spectrum disorder studies showed the most consistent evidence (g = 0.264, 95% CI: 0.107, 0.421), while other conditions showed wider confidence intervals. Age-stratified analysis showed that adult populations (mean age 23.3 years, n = 5 outcomes) demonstrated higher effect sizes (g = 0.463, SD = 0.402) compared to pediatric populations (mean age 11.8 years, n = 8 outcomes; g = 0.318, SD = 0.212). Whole plant preparations (g = 0.328, 95% CI: 0.083, 0.573) and pharmaceutical cannabinoids (g = 0.292, 95% CI: 0.069, 0.515) showed comparable effects. CBD dosages ranged from 17.5 mg to 600 mg per day, with no significant correlation between dosage and effect size (ρ = -0.014, p = 0.963). Mild to moderate side effects were reported, but no serious adverse events. Risk of bias assessment ranged from low (n = 3) to high (n = 5).

Conclusion: While meta-analysis of effect sizes for primary outcomes revealed modest positive effects, particularly for autism spectrum disorders, the current evidence remains insufficient to broadly recommend cannabinoids for treating mental disorders in youth populations. Larger, controlled studies with standardized outcomes are needed to establish definitive clinical recommendations.

背景:大麻素越来越引起人们的兴趣,主要是因为它们被认为对广泛的精神、心身和神经疾病有疗效。目的:本系统综述旨在综合随机安慰剂对照试验的结果,研究大麻素作为治疗儿童、青少年和年轻人精神疾病的疗效和剂量。方法:从PubMed和Embase检索到2024年6月30日的所有出版物。按照prisma准则适用了资格标准。包括提供大麻素治疗精神障碍的治疗前和治疗后参数的随机对照试验,与0至25岁的对照组进行比较。主要结果的效应大小以Hedges' g计算,并进行了多水平随机效应荟萃分析,以解释来自相同研究人群的依赖结果。结果:我们确定了7603份记录,其中8项独立临床试验(在9份出版物中报道)符合预先建立的资格标准,包括474名独特参与者(245名治疗组,229名对照组)。对7项临床试验的13项主要结果的分析显示,对症状改善或脑生理正常化的总体积极影响(Hedges' g = 0.308, 95% CI: 0.167, 0.448)。自闭症谱系障碍研究显示了最一致的证据(g = 0.264, 95% CI: 0.107, 0.421),而其他条件则显示了更广泛的置信区间。年龄分层分析显示,成人人群(平均年龄23.3岁,n = 5个结局)比儿科人群(平均年龄11.8岁,n = 8个结局)具有更高的效应量(g = 0.463, SD = 0.402);g = 0.318, SD = 0.212)。全植物制剂(g = 0.328, 95% CI: 0.083, 0.573)和药用大麻素(g = 0.292, 95% CI: 0.069, 0.515)的效果相当。CBD剂量范围为17.5 mg /天至600 mg /天,剂量与效应大小无显著相关性(ρ = -0.014, p = 0.963)。有轻度到中度的副作用报道,但没有严重的不良事件。偏倚评估风险从低(n = 3)到高(n = 5)不等。结论:虽然对主要结果的效应大小的荟萃分析显示出适度的积极作用,特别是对自闭症谱系障碍,但目前的证据仍然不足以广泛推荐大麻素用于治疗青少年人群的精神障碍。需要有标准化结果的大型对照研究来建立明确的临床建议。
{"title":"Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials.","authors":"Patrick Köck, Andrzej Badek, Maximilian Meyer, Arndt-Lukas Klaassen, Marc Walter, Jochen Kindler","doi":"10.1186/s13034-024-00846-5","DOIUrl":"10.1186/s13034-024-00846-5","url":null,"abstract":"<p><strong>Background: </strong>Cannabinoids have been of increasing interest mainly due to their putative efficacy in a wide array of psychiatric, psychosomatic, and neurological conditions.</p><p><strong>Aims: </strong>This systematic review aims to synthesize results from randomized placebo-controlled trials regarding the efficacy and the dosage of cannabinoids as therapeutics in psychiatric disorders in children, adolescents, and young adults.</p><p><strong>Methods: </strong>All publications up to June 30th, 2024, were included from PubMed and Embase. Eligibility criteria in accordance with the PRISMA-guidelines was applied. RCTs providing pre- and post-treatment parameters on cannabinoid therapies for mental disorders in comparison to controls in an age range from 0 to 25 years were included. Effect sizes were calculated as Hedges' g for primary outcomes, and a multilevel random-effects meta-analysis was conducted to account for dependent outcomes from same study populations.</p><p><strong>Results: </strong>We identified 7603 records, of which 8 independent clinical trials (reported in 9 publications) met the pre-established eligibility criteria, comprising 474 unique participants (245 treatment, 229 control). Analysis of 13 primary outcomes (of 7 clinical trials) revealed a modest positive overall effect for symptom improvement or normalization of brain physiology (Hedges' g = 0.308, 95% CI: 0.167, 0.448). Autism spectrum disorder studies showed the most consistent evidence (g = 0.264, 95% CI: 0.107, 0.421), while other conditions showed wider confidence intervals. Age-stratified analysis showed that adult populations (mean age 23.3 years, n = 5 outcomes) demonstrated higher effect sizes (g = 0.463, SD = 0.402) compared to pediatric populations (mean age 11.8 years, n = 8 outcomes; g = 0.318, SD = 0.212). Whole plant preparations (g = 0.328, 95% CI: 0.083, 0.573) and pharmaceutical cannabinoids (g = 0.292, 95% CI: 0.069, 0.515) showed comparable effects. CBD dosages ranged from 17.5 mg to 600 mg per day, with no significant correlation between dosage and effect size (ρ = -0.014, p = 0.963). Mild to moderate side effects were reported, but no serious adverse events. Risk of bias assessment ranged from low (n = 3) to high (n = 5).</p><p><strong>Conclusion: </strong>While meta-analysis of effect sizes for primary outcomes revealed modest positive effects, particularly for autism spectrum disorders, the current evidence remains insufficient to broadly recommend cannabinoids for treating mental disorders in youth populations. Larger, controlled studies with standardized outcomes are needed to establish definitive clinical recommendations.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":"18 1","pages":"158"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal trends and social inequities in adolescent and young adult mental health disorders in Catalonia, Spain: a 2008-2022 primary care cohort study. 西班牙加泰罗尼亚青少年和青年心理健康障碍的时间趋势和社会不平等:2008-2022年初级保健队列研究
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-18 DOI: 10.1186/s13034-024-00849-2
Ana Lozano-Sánchez, Enric Aragonès, Tomàs López-Jiménez, Matthew Bennett, Stella Evangelidou, Esther Francisco, Myriam García, Estel Malgosa, Núria Codern-Bové, Claudia Guzmán-Molina, Constanza Jacques-Aviñó

Background: The prevalence of mental health disorders in children, teens, and young adults is rising at an alarming rate. This study aims to explore time trends in the incidence of mental disorders among young people in Catalonia, Spain from 2008 to 2022, focusing on the effects of the COVID-19 pandemic and from the perspective of social inequities.

Methods: A cohort study using primary care records from the SIDIAP database was conducted. It included 2,088,641 individuals aged 10 to 24 years. We examined the incidence of depressive, anxiety, eating, and attention deficit/hyperactivity disorders, stratified by sex, age, deprivation, and nationality.

Results: All disorders reflected an increasing trend throughout the study period: depressive disorders (IRR: 2.44, 95% CI: 2.31-2.59), anxiety disorders (IRR: 2.33, 95% CI: 2.27-2.39), ADHD (IRR: 2.33, 95%CI: 2.17-2.50), and eating disorders (IRR: 3.29, 95% CI: 3.01-3.59). A significant increase in incidence was observed after the outbreak of the COVID-19 pandemic. In 2022, anxiety disorders were most frequent, with an incidence rate (IR) of 2,537 per 100,000 persons-year (95% CI: 2,503-2,571). Depressive disorders followed with an IR of 471 (95% CI: 458-486), ADHD with an IR of 306 (95% CI: 295-317) and eating disorders with an IR of 249 (95% CI: 239-259). Significant associations were reported with sex, age, deprivation, and nationality.

Conclusion: The incidence of all studied disorders has steadily increased, reaching unprecedented levels during the pandemic. Understanding these trends is essential for an appropriate healthcare response, while addressing the non-medical determinants, requires action across all sectors of society.

背景:儿童、青少年和年轻人中精神健康障碍的患病率正以惊人的速度上升。本研究旨在探讨2008年至2022年西班牙加泰罗尼亚年轻人精神障碍发病率的时间趋势,重点关注COVID-19大流行的影响,并从社会不平等的角度进行研究。方法:使用SIDIAP数据库中的初级保健记录进行队列研究。该研究包括2088641名年龄在10至24岁之间的人。我们检查了抑郁、焦虑、饮食和注意缺陷/多动障碍的发生率,并按性别、年龄、剥夺和国籍分层。结果:在整个研究期间,所有障碍均呈上升趋势:抑郁症(IRR: 2.44, 95%CI: 2.31-2.59)、焦虑症(IRR: 2.33, 95%CI: 2.27-2.39)、多动症(IRR: 2.33, 95%CI: 2.17-2.50)和饮食障碍(IRR: 3.29, 95%CI: 3.01-3.59)。在2019冠状病毒病大流行爆发后,观察到发病率显著增加。2022年,焦虑症最为常见,发病率(IR)为每10万人每年2537例(95% CI: 2503 - 2571)。抑郁症的IR为471 (95% CI: 458-486),多动症的IR为306 (95% CI: 295-317),饮食失调的IR为249 (95% CI: 239-259)。据报道,与性别、年龄、剥夺和国籍有显著关联。结论:所研究疾病的发病率稳步上升,在大流行期间达到前所未有的水平。了解这些趋势对于采取适当的医疗应对措施至关重要,同时解决非医疗决定因素,需要社会所有部门采取行动。
{"title":"Temporal trends and social inequities in adolescent and young adult mental health disorders in Catalonia, Spain: a 2008-2022 primary care cohort study.","authors":"Ana Lozano-Sánchez, Enric Aragonès, Tomàs López-Jiménez, Matthew Bennett, Stella Evangelidou, Esther Francisco, Myriam García, Estel Malgosa, Núria Codern-Bové, Claudia Guzmán-Molina, Constanza Jacques-Aviñó","doi":"10.1186/s13034-024-00849-2","DOIUrl":"10.1186/s13034-024-00849-2","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of mental health disorders in children, teens, and young adults is rising at an alarming rate. This study aims to explore time trends in the incidence of mental disorders among young people in Catalonia, Spain from 2008 to 2022, focusing on the effects of the COVID-19 pandemic and from the perspective of social inequities.</p><p><strong>Methods: </strong>A cohort study using primary care records from the SIDIAP database was conducted. It included 2,088,641 individuals aged 10 to 24 years. We examined the incidence of depressive, anxiety, eating, and attention deficit/hyperactivity disorders, stratified by sex, age, deprivation, and nationality.</p><p><strong>Results: </strong>All disorders reflected an increasing trend throughout the study period: depressive disorders (IRR: 2.44, 95% CI: 2.31-2.59), anxiety disorders (IRR: 2.33, 95% CI: 2.27-2.39), ADHD (IRR: 2.33, 95%CI: 2.17-2.50), and eating disorders (IRR: 3.29, 95% CI: 3.01-3.59). A significant increase in incidence was observed after the outbreak of the COVID-19 pandemic. In 2022, anxiety disorders were most frequent, with an incidence rate (IR) of 2,537 per 100,000 persons-year (95% CI: 2,503-2,571). Depressive disorders followed with an IR of 471 (95% CI: 458-486), ADHD with an IR of 306 (95% CI: 295-317) and eating disorders with an IR of 249 (95% CI: 239-259). Significant associations were reported with sex, age, deprivation, and nationality.</p><p><strong>Conclusion: </strong>The incidence of all studied disorders has steadily increased, reaching unprecedented levels during the pandemic. Understanding these trends is essential for an appropriate healthcare response, while addressing the non-medical determinants, requires action across all sectors of society.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":"18 1","pages":"159"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating recovery in childhood OCD: a qualitative analysis of barriers and facilitators. 在儿童强迫症中导航康复:障碍和促进因素的定性分析。
IF 3.4 3区 医学 Q1 PEDIATRICS Pub Date : 2024-12-18 DOI: 10.1186/s13034-024-00851-8
Lakshmi Sravanti, Rajendra Kiragasur Madegowda, Arul Jayendra Pradeep Velusamy, John Vijay Sagar Kommu, Satish Chandra Girimaji, Shekhar Seshadri

Objective: The objective is to examine barriers and facilitators to recovery in children and adolescents with obsessive-compulsive disorder (OCD) using a qualitative approach.

Methods: Ten semi-structured interviews were conducted, audio-recorded, and analyzed using thematic analysis. Findings were validated through investigator triangulation, peer validation and member check.

Results: Barriers to recovery were internal-lack of awareness; poor motivation to seek treatment; and perceived stigma, or external-poor parental support; parental anxiety; inadequate awareness in schools; social misconceptions about illness; myths about medication; and frustrations in treatment processes. Facilitators were internal-will and determination; self-discipline; keeping calm; sense of purpose, and external-general awareness; parental support; peer support; and good therapeutic engagement.

Conclusions: To the best of our knowledge, this is the first study to explore barriers and facilitators to recovery in-depth in pediatric OCD. Findings underscore the importance of tailored interventions, robust support networks, and cultural sensitivity for successful recovery outcomes.

目的:目的是检查障碍和促进恢复的儿童和青少年强迫症(OCD)使用定性方法。方法:进行10次半结构化访谈,录音,采用主题分析法进行分析。研究结果通过研究者三角测量、同行验证和成员检查进行验证。结果:康复的障碍是内在意识的缺乏;寻求治疗的动机差;以及感知到的耻辱,或者缺乏父母的外部支持;父母的焦虑;学校意识不足;社会对疾病的误解;关于药物的误解;以及治疗过程中的挫折。促成因素是内在的意志和决心;自律;保持冷静;目的感和外部一般意识;父母的支持;同伴支持;良好的治疗参与。结论:据我们所知,这是第一个深入探讨儿童强迫症恢复障碍和促进因素的研究。研究结果强调了量身定制的干预措施、强大的支持网络和文化敏感性对成功恢复结果的重要性。
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引用次数: 0
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Child and Adolescent Psychiatry and Mental Health
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