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Preparation and Application of Sulfur and Nitrogen Co-doped Carbon Quantum Dots 硫氮共掺杂碳量子点的制备与应用
Pub Date : 2021-06-01 DOI: 10.19894/J.ISSN.1000-0518.200268
Wen Guang-ming, Jiao Ting, DU Xiao-Yan, Liao Zhong-ping
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引用次数: 0
Synthesis and Evaluation of High Temperature Resistant Zirconium Boron Crosslinker for Fracturing Fluid 压裂液用耐高温锆硼交联剂的合成与评价
Pub Date : 2021-06-01 DOI: 10.19894/J.ISSN.1000-0518.200276
Yang Yang, Chen Qi, Li Zhi-peng, GU Zhuo-Ran, YE Shi-Gui, She Xue
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引用次数: 1
Preparation, Characterization and Performance of Gelatin Modified Polyetheretherketone Microcarriers 明胶改性聚醚醚酮微载体的制备、表征及性能研究
Pub Date : 2021-06-01 DOI: 10.19894/J.ISSN.1000-0518.210040
Jiao Zi-Xue, Gao Cheng-Zhe, Sun Shuo, WU Zhen-Xu, Zhang Pei-Biao
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引用次数: 0
Developing new stereochemistry antimicrobial strategy to advance biosafety materials 开发新的立体化学抗菌策略以推进生物安全材料
Pub Date : 2021-05-01 DOI: 10.19894/j.issn.1000-0518.210070
Xie Zi-Xu, Zhang Peng-fei, W. Xing
The outbreak of Corona Virus (COVID-19) and its periodic changes of its epidemic pose a serious threat to human health, which has brought the biosafety problem back to the public view and has attracted the worldwide attention. Governments all over the world have begun to strengthen biosafety measures, and there is an urgent need for effective materials to deal with biosafety threats. Antimicrobial material is an important component of biosafety materials, and is committed to solve the thorny biosafety problem of microbial infections. Traditional antimicrobial strategies include sterilization, antimicrobial adhesion and antimicrobial composite. The traditional strategy is mainly based on sterilization, which takes effect quickly. However, the antimicrobial agents used in materials are easy to lose, thus making poor biocompatibility. What′s worse, it may lead to microbial resistance issue. Therefore, the development of new antimicrobial strategies is of great significance. The stereochemical strategy is based on the reversible recognition of the microbes on a material surface, allowing the microbes to autonomously leave the surface when they distinguish the stereochemical signals of the materials. This strategy, in line with the development trend, can effectively inhibit the adhesion, propagation and spread of various microorganisms. This review briefly summarizes the research progress of antibacterial materials in the past five years, and the current researches of stereochemical antimicrobial strategies. The new concept for a management and control of microbial behavior is further discussed. © 2021, Science in China Press. All rights reserved.
新冠肺炎的爆发及其疫情的周期性变化对人类健康构成了严重威胁,使生物安全问题重新回到公众视野,引起了全世界的关注。世界各国政府已开始加强生物安全措施,迫切需要有效的材料来应对生物安全威胁。抗菌材料是生物安全材料的重要组成部分,致力于解决微生物感染这一棘手的生物安全问题。传统的抗菌策略包括杀菌、抗菌粘附和抗菌复合。传统的策略主要基于杀菌,杀菌效果很快。然而,材料中使用的抗菌剂很容易丢失,从而导致生物相容性较差。更糟糕的是,它可能会导致微生物耐药性问题。因此,开发新的抗菌策略具有重要意义。立体化学策略基于对材料表面微生物的可逆识别,允许微生物在区分材料的立体化学信号时自主离开表面。这种策略符合发展趋势,可以有效抑制各种微生物的粘附、繁殖和传播。本文简要综述了近五年来抗菌材料的研究进展,以及立体化学抗菌策略的研究现状。进一步讨论了微生物行为管理和控制的新概念。©2021,中国科学出版社。保留所有权利。
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引用次数: 0
Research Progress of Biosafety Materials and Technology of Genetic Resource Preservation 生物安全材料与遗传资源保护技术研究进展
Pub Date : 2021-05-01 DOI: 10.19894/J.ISSN.1000-0518.210056
Ma Yi-ming, Zhou Xiao, Tian Yun-qing, Yang Jing, Zhang Lei
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引用次数: 1
Application of nano biomaterials in antiviral vaccine adjuvant 纳米生物材料在抗病毒疫苗佐剂中的应用
Pub Date : 2021-05-01 DOI: 10.19894/j.issn.1000-0518.210062
L. Cao, Z. Wang, B. Wang
Viral infectious diseases seriously endanger human health, the new type of coronary pneumonia has become a major global public safety and health incident. Vaccination is an important way to effectively prevent and control viral infections and the spread of infectious diseases. While routine vaccines have shown a shortfall, such as short half-life, weak immunogenicity, weak targeting, slow absorption, and high storage and delivery requirements. In recent years, nanobiomaterials are expected to be used as vaccine adjuvants for the prevention and treatment of viral infectious diseases due to their lower systemic toxicity, stronger tissue targeting, higher specific surface area and lower immune titer. This review will focus on the classification, action pathways and mechanisms of nanobiomaterials as adjuvants for antiviral vaccines. In addition, the application of nanobiomaterials in the new crown vaccine is described in combination with coronavirus disease-19 (COVID-19), which is currently popular worldwide. Finally, the challenges faced by nanobiomaterials in antiviral vaccine adjuvants are summarized. © 2021, Science in China Press. All rights reserved.
病毒性传染病严重危害人类健康,新型冠状肺炎已成为全球性重大公共安全卫生事件。疫苗接种是有效预防和控制病毒感染和传染病传播的重要途径。常规疫苗存在半衰期短、免疫原性弱、靶向性弱、吸收慢、储存和运送要求高等不足。近年来,纳米生物材料因其较低的系统毒性、较强的组织靶向性、较高的比表面积和较低的免疫滴度,有望作为疫苗佐剂用于病毒性传染病的预防和治疗。本文就纳米生物材料作为抗病毒疫苗佐剂的分类、作用途径和机制作一综述。此外,结合目前全球流行的冠状病毒病-19 (COVID-19),介绍了纳米生物材料在新冠疫苗中的应用。最后,总结了纳米生物材料在抗病毒疫苗佐剂中面临的挑战。©2021,中国科学出版社版权所有。
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引用次数: 3
Research progresses of nucleic acid based detection of pathogenic microorganisms. (Special Issue: Biosafety materials.) [Chinese] 病原微生物核酸检测的研究进展。(特刊:生物安全材料)
Pub Date : 2021-05-01 DOI: 10.19894/J.ISSN.1000-0518.210099
Liu Zi-yue, Yang Tong-Ren, Y. Ge, Huang Yuanyu
In December 2019, the global outbreak of Corona Virus Disease 2019 (COVID-19)made biosafety an attractive and crucial development direction globally. Rapid, accurate and low-cost detection of pathogenic microorganisms is one of the important issue to ensure biosafety, and is the key to epidemic prevention, control and diagnosis. This review elaborately introduces the applications of biosensors based on nucleic acid sequencing, isothermal amplification and gene editing (CRISPR/Cas) in integrated portable devices. The development of these technologies offers the possibility of developing low-cost, high-efficiency and result-visualization integrated detection methods. It is expected to provide technology guarantees for the effective prevention and control of pathogenic microorganisms.
2019年12月,2019冠状病毒病(COVID-19)在全球爆发,使生物安全成为全球具有吸引力和关键的发展方向。病原微生物的快速、准确、低成本检测是保证生物安全的重要问题之一,是疫情防控和诊断的关键。本文详细介绍了基于核酸测序、等温扩增和基因编辑(CRISPR/Cas)技术的生物传感器在集成便携式设备中的应用。这些技术的发展为开发低成本、高效率和结果可视化的综合检测方法提供了可能。有望为有效防治病原微生物提供技术保障。
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引用次数: 0
Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance 肽基自组装纳米材料抗微生物耐药性研究进展
Pub Date : 2021-05-01 DOI: 10.19894/J.ISSN.1000-0518.210057
Liu Jiao, Zou Peng-fei, L. Ping, Zhang Xiao, W. xin-xin, Gao Yuanyuan, Lin Li-li
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引用次数: 0
Biosafety Materials for Bioterrorism Attacks and Biological Warfare 用于生物恐怖袭击和生物战的生物安全材料
Pub Date : 2021-05-01 DOI: 10.19894/J.ISSN.1000-0518.210074
Cui Min-Hui, Zhou Hui-ling, Tang Dong-sheng, Xia Hai-hua
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引用次数: 1
Research progress on biosafety materials for the prevention and control of the coronavirus disease 2019. (Special Issue: Biosafety materials.) [Chinese] 2019冠状病毒病防控生物安全材料研究进展(特刊:生物安全材料)
Pub Date : 2021-05-01 DOI: 10.19894/J.ISSN.1000-0518.210053
M. Cai
Biosafety has seriously threatened the survival and development of human beings. Under the situation of the coronavirus disease 2019 (COVID-19) epidemic and the normalization of anti-epidemic, biosafety prevention and control is becoming more and more important, which is directly related to the development of society, economy and politics. At the beginning of COVID-19 epidemic, there was a serious lack of personal protective equipment, due to the shortage of medical emergency supplies and the lack of ability to public health emergencies. In the face of the severe challenge of the epidemic, interdisciplinary and multidisciplinary cooperation is the key to scientific epidemic prevention. The characteristics of the material, such as optical, electrical, acoustic, magnetic, thermal, are helpful for the design and preparation of multi-functional new materials, which can meet the requirements of biosafety prevention in detection, prevention and treatment. We should give full play to the advantages of biosafety and materials science. Using new biosafety materials to overcome the shortcomings of traditional materials can improve or provide new detection methods. Not only can we use biosafety materials to develop a variety of highly effective, low toxicity drugs and vaccines, but also to produce multifunctional masks and protective clothing. What we have done has contributed to the preparation of medical emergency supplies and to the fight against the COVID-19 pandemic. At the same time, the toxicity of new biosafety materials can not be ignored. Only by accelerating industrialization based on basic research and practical problems can we better cope with other emerging outbreaks of infectious diseases in the future.
生物安全已经严重威胁到人类的生存和发展。在2019冠状病毒病(新冠肺炎)疫情和抗疫常态化的形势下,生物安全防控越来越重要,直接关系到社会、经济和政治的发展。新冠肺炎疫情初期,由于医疗应急物资短缺和突发公共卫生事件能力不足,个人防护装备严重缺乏。面对疫情的严峻挑战,跨学科、多学科合作是科学防疫的关键。该材料的光、电、声、磁、热等特性有助于设计和制备多功能新材料,能够满足检测、预防和治疗中生物安全预防的要求。我们应该充分发挥生物安全和材料科学的优势。利用新型生物安全材料克服传统材料的缺点,可以改进或提供新的检测方法。我们不仅可以利用生物安全材料开发各种高效、低毒的药物和疫苗,还可以生产多功能口罩和防护服。我们所做的一切为医疗应急物资的准备和抗击新冠肺炎疫情做出了贡献。同时,新型生物安全材料的毒性也不容忽视。只有基于基础研究和实际问题加快工业化,我们才能更好地应对未来其他新出现的传染病疫情。
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引用次数: 0
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