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Oscillation quenching induced by time-varying coupling functions. 时变耦合函数引起的振荡猝灭。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-12-01 DOI: 10.1063/5.0306383
Dushko Stavrov, Aneta Koseska, Tomislav Stankovski

The oscillatory dynamics of natural and man-made systems can be disrupted by their time-varying interactions, leading to oscillation quenching phenomena in which the oscillations are suppressed. We introduce a framework for analyzing, assessing, and controlling oscillation quenching using coupling functions. Specifically, by observing limit-cycle oscillators, we investigate the bifurcations and dynamical transitions induced by time-varying diffusive and periodic coupling functions. We studied the transitions between oscillation quenching states induced by the time-varying form of the coupling function while the coupling strength is kept invariant. The time-varying periodic coupling function allowed us to identify novel, non-trivial inhomogeneous states that have not been reported previously. Furthermore, by using dynamical Bayesian inference, we have also developed a Proportional Integral controller that maintains the oscillations and prevents oscillation quenching from occurring. In addition to the present implementation and its generalizations, the framework carries broader implications for identification and control of oscillation quenching in a wide range of systems subjected to time-varying interactions.

自然和人为系统的振荡动力学可以被它们的时变相互作用所破坏,导致振荡猝灭现象,其中振荡被抑制。我们介绍了一个利用耦合函数分析、评估和控制振荡猝灭的框架。具体地说,通过观察极限环振子,我们研究了时变扩散和周期耦合函数引起的分岔和动态跃迁。研究了在耦合强度保持不变的情况下,耦合函数的时变形式引起的振荡猝灭态之间的转变。时变周期耦合函数使我们能够识别以前未报道的新颖的、非平凡的非齐次状态。此外,通过使用动态贝叶斯推理,我们还开发了一个比例积分控制器来维持振荡并防止振荡猝灭的发生。除了目前的实现及其推广外,该框架还具有更广泛的含义,可用于识别和控制受时变相互作用影响的大范围系统中的振荡猝灭。
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引用次数: 0
A reference-free optical method for assessing cardiac ischemia via NADH autofluorescence dynamics. 一种通过NADH自身荧光动力学评估心脏缺血的无参比光学方法。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-12-01 DOI: 10.1063/5.0297249
M M Slotvitsky, M S Medvedev, G S Pashintsev, V S Kachan, S A Romanova, K I Agladze, V A Tsvelaya

The conversion of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH) by dehydrogenases is a key step in numerous redox reactions and, consequently, in cellular energy conversion. NADH autofluorescence imaging represents a promising method for the optical detection of metabolic dysfunction in living tissues. However, it is sensitive to the total NAD(H) content as well as to variations in absorption and light scattering, which may fluctuate independently. A major objective is, therefore, to identify invariant quantities that are responsive to reversible ischemic tissue injury while circumventing the limitations of intensity-based imaging. We show experimentally and in silico that glutamate dehydrogenase (GDH) drives the NAD+/NADH balance toward a competing semi-equilibrium (CSE) state when an external catalytic process promotes the NADH → NAD+ conversion. This CSE state is uniquely determined by the total NAD(H) pool, the GDH concentration, and the external catalytic activity. Experimental validation using UV-induced NADH photolysis (300-500 mW/cm2), implementing the NADH → NAD+ reaction, showed that GDH activity can be estimated in the epicardium of ex vivo Langendorff-perfused hearts by analyzing the CSE. These results present a new approach to the optical assessment of tissue metabolic activity based on autofluorescence imaging of NADH. Our method allows the assessment of cardiac tissue ischemia without knowledge of the photolysis rate, thereby overcoming the inherent limitations of optical detection in living tissues.

脱氢酶将烟酰胺腺嘌呤二核苷酸(NAD+)转化为其还原形式(NADH)是许多氧化还原反应的关键步骤,因此也是细胞能量转化的关键步骤。NADH自身荧光成像是一种很有前途的方法,用于光学检测代谢功能障碍的活组织。然而,它对总NAD(H)含量以及吸收和光散射的变化敏感,这些变化可能独立波动。因此,一个主要的目标是识别对可逆性缺血性组织损伤有反应的不变量,同时规避基于强度的成像的局限性。我们通过实验和计算机模拟表明,当外部催化过程促进NADH→NAD+转化时,谷氨酸脱氢酶(GDH)将NAD+/NADH平衡推向竞争半平衡(CSE)状态。这种CSE状态是由总NAD(H)池、GDH浓度和外部催化活性唯一决定的。实验验证采用紫外线诱导NADH光解(300-500 mW/cm2),实现NADH→NAD+反应,表明通过分析CSE可以估计langendorff体外灌注心脏心外膜中GDH的活性。这些结果提出了一种基于NADH自身荧光成像的组织代谢活性光学评估的新方法。我们的方法可以在不了解光解速率的情况下评估心脏组织缺血,从而克服了活体组织光学检测的固有局限性。
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引用次数: 0
Reservoir computing on manifolds. 流形上的储层计算。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0273628
Masato Hara, Hiroshi Kokubu

Reservoir computing has attracted considerable attention as an effective method for learning chaotic time series generated by dynamical systems. In this paper, we propose a new reservoir computing approach that is adapted to dynamical systems on general manifolds, representing a natural extension of the usual method for dynamical systems on the Euclidean spaces. We also present numerical results for learning the hyperbolic toral automorphism and the tripling map on the circle to demonstrate that the proposed method performs effectively.

储层计算作为一种学习由动力系统产生的混沌时间序列的有效方法,受到了广泛的关注。本文提出了一种适用于一般流形上动力系统的储层计算方法,这是欧几里德空间上动力系统计算方法的自然推广。最后给出了学习双曲总自同构和圆上的三倍映射的数值结果,证明了该方法的有效性。
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引用次数: 0
Nonautonomous scalar concave-convex differential equations: Conditions for uniform stability or bistability in a model of optical fluorescence. 非自治标量凹凸微分方程:光学荧光模型中均匀稳定或双稳定的条件。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0288308
J Dueñas, C Núñez, R Obaya

We investigate the long-term dynamics of a nonautonomous Bonifacio-Lugiato model of optical superfluorescence. The scalar ordinary differential equation modeling the phenomenon is given by a concave-convex autonomous function of the state variable that is excited by a time-dependent input, Λ(t). We describe the system's response in terms of the dynamical characteristics of the input function, with particular focus on the cases of uniform stability-when exactly a bounded solution exists, which in addition is hyperbolic attractive-or bistability-when two stable solutions of this type coexist. Our starting point is the open interval delimited by the constant input values λ for which the autonomous version of our model was already known to exhibit bistability: we prove that, in general, bistability occurs when Λ(t) lies within this interval. This condition is sufficient but not necessary. Applying nonautonomous bifurcation methods and imposing more restrictive conditions on the variation of Λ(t), we can determine the necessary and sufficient conditions for bistability and to prove that the general response is uniform stability when these conditions are not satisfied. Finally, we analyze the case of a periodic input that varies on a slow timescale using fast-slow system methods to rigorously establish either a uniformly stable or a bistable response.

我们研究了光学超荧光的非自治Bonifacio-Lugiato模型的长期动力学。描述该现象的标量常微分方程由状态变量的凹凸自治函数给出,该状态变量由一个时变输入Λ(t)激发。我们根据输入函数的动态特性描述系统的响应,特别关注一致稳定的情况-当一个有界解存在时,它是双曲吸引的-或者双稳定-当两个稳定解共存时。我们的起点是由恒定输入值λ划分的开区间,对于这个开区间,我们的模型的自治版本已经知道表现出双稳定性:我们证明,一般来说,双稳定性发生在Λ(t)位于这个区间内。这个条件是充分的,但不是必要的。应用非自治分岔方法,对Λ(t)的变化施加更多的限制条件,我们可以确定双稳定的充分必要条件,并证明当这些条件不满足时,一般响应是一致稳定的。最后,我们分析了周期输入在慢时间尺度上变化的情况,使用快慢系统方法严格地建立一致稳定或双稳态响应。
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引用次数: 0
Chaos in the Duffing oscillator beyond the Melnikov criterion. 杜芬振子在梅尔尼科夫准则之外的混沌。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0289360
Junfeng Cheng, Xiao-Song Yang

In this paper, we revisit the classical perturbed Duffing system and investigate its intricate dynamical behavior through the numerical method based on the topological horseshoe theory employing the Runge-Kutta method. Based on the classical Melnikov analysis, we explore the persistence of chaotic dynamics beyond the parameter regimes in which the Melnikov condition guarantees the existence of a transverse homoclinic intersection. Specifically, we examine the second return map and demonstrate the existence of a topological horseshoe at parameter values εγ=0.4, εδ=0.54, and ω=1. This provides numerical evidence to Smale horseshoe-type chaos in a regime where the Melnikov criterion is not satisfied. Furthermore, we provide a more rigorous treatment on the existence of the topological horseshoe in terms of crossing stability.

本文基于拓扑马蹄形理论,采用龙格-库塔方法,对经典扰动Duffing系统的复杂动力学行为进行了数值研究。在经典Melnikov分析的基础上,我们探讨了在Melnikov条件保证横切同斜交存在的参数区之外混沌动力学的持续性。具体地说,我们检验了第二个返回图,并证明了在参数值εγ=0.4, εδ=0.54和ω=1时拓扑马蹄形的存在性。这为不满足Melnikov准则的小马蹄形混沌提供了数值证据。此外,我们在交叉稳定性方面对拓扑马蹄形的存在性提供了更严格的处理。
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引用次数: 0
Understanding ecological cascade in cyclic game systems by means of directed graphs. 用有向图的方法理解循环博弈系统中的生态级联。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0294984
Ryoo Kyung Yang, Seungmo Hong, Suhyeon Kim, Junpyo Park

Evolutionary game-based models hold a potential key to help interpret the evolution of systems based on the interaction of multispecies. In particular, in ecosystems with structures such as food webs, the extinction of one species through competition can lead to secondary extinctions, and such ecological cascades are common in cyclic game systems governed by the rock-paper-scissors metaphor. In this paper, we delve into ecological cascades in the evolution of cyclically competing populations by using directed graphs. By revisiting previous studies of cyclic game systems, we identify a common mathematical property in evolutionary directed graphs and predict evolution in terms of tournaments. We further compare a theoretical result with Monte Carlo simulations, which shows that the graph-based interpretation of ecological cascades is qualitatively consistent with numerical simulations. Ultimately, we may emphasize that the method based on directed graphs would be more practical for understanding the evolution of multispecies than numerical simulations.

基于进化博弈的模型可能有助于解释基于多物种相互作用的系统进化。特别是,在具有食物网等结构的生态系统中,一个物种通过竞争灭绝可能导致二次灭绝,这种生态级联在由石头剪刀布隐喻控制的循环游戏系统中很常见。本文用有向图的方法研究了生态级联在周期性竞争种群进化中的作用。通过回顾之前对循环博弈系统的研究,我们在进化有向图中发现了一个共同的数学性质,并根据比赛预测了进化。我们进一步将理论结果与蒙特卡罗模拟结果进行了比较,结果表明基于图的生态级联解释与数值模拟在质量上是一致的。最后,我们可以强调,基于有向图的方法将比数值模拟更实用于理解多物种的进化。
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引用次数: 0
Electrical wave propagation in memristive cardiac tissue under electric field. 电场作用下记忆性心脏组织中的电波传播。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0292369
Chunni Wang, Zixuan Zhang, Zhao Lei, Jun Ma

Inspired by the physical property of charge-controlled memristor, equivalent memristive current and charge variable are used to describe the wave stability in cardiac tissue under an electric field. The memristive current generated in a single myocardial cell results from the changes in the static distribution of intracellular ions and external forced electric field. A reaction-diffusion equation is used to estimate the propagation of electrical signals in the cardiac tissue as traveling waves, and the variations in memristive currents and charge levels reflect the effect of the electric field on the cardiac electrical behaviors, which are illustrated by the wave propagation and patterns' stability in the excitable media. An external stimulus is applied to control the wave propagation, and the self-sustained wave property is explored. An external electric field is applied to control the charge pumping and the wave stability is controlled. The improved memristive cardiac model considering the effect of electric fields is converted into an equivalent neural network for finding a numerical solution, and the statistical synchronization factor and energy function are defined for the theoretical analysis. This theoretical memristive cardiac model is effective to discover the wave characteristic, and then, an appropriate control scheme can be applied to prevent wave instability (breakup of spiral waves). As a result, heartbeat is maintained by generating and propagating continuous wavefronts in the cardiac tissue, and then, blood is pumped in and out of the heart exposed to an external electric field.

受电荷控忆阻器物理特性的启发,用等效忆阻电流和电荷变量来描述电场作用下心脏组织的波稳定性。单个心肌细胞内产生的记忆电流是细胞内离子静态分布和外加强电场变化的结果。用反应扩散方程来估计电信号在心脏组织中的行波传播,记忆电流和电荷水平的变化反映了电场对心脏电行为的影响,这可以通过波在可激介质中的传播和模式的稳定性来说明。利用外部刺激控制波的传播,探讨了波的自持续特性。利用外加电场控制电荷泵送,控制波的稳定性。将考虑电场影响的改进记忆心脏模型转化为等效神经网络进行数值求解,并定义统计同步因子和能量函数进行理论分析。该理论记忆体模型可以有效地发现心脏的波动特征,从而采用适当的控制方案来防止波动不稳定(螺旋波破裂)。因此,心跳是通过在心脏组织中产生和传播连续的波阵面来维持的,然后,血液被泵入和泵出心脏,暴露在外部电场中。
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引用次数: 0
Threshold dynamics and epidemic-informed machine learning for forecasting of mpox: A U.S. case study. 阈值动态和流行病信息机器学习预测mpox:一个美国案例研究。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0299032
S Nivetha, Parthasakha Das, Mini Ghosh

Mpox (monkeypox) is a re-emerging viral disease with increasingly sustained human transmission, particularly in previously unaffected regions. In this study, we develop a compartmental epidemic model that captures mpox transmission dynamics and incorporates a treatment function to assess the impact of medical interventions on disease progression and recovery. The model is calibrated using U.S. case data, with parameters estimated via the Trust Region Reflective optimization method to ensure close alignment with observed trends. We perform global sensitivity analysis using partial rank correlation coefficients to identify key parameters influencing transmission. The model's bifurcation structure is examined through the basic reproduction number RM0, revealing both forward and backward bifurcations that highlight threshold behavior and the potential for complex endemic dynamics. For real-time forecasting, we incorporate prior knowledge of mpox dynamics into machine learning models, ARNN (Autoregressive Neural Network), ARIMA (Autoregressive Integrated Moving Average), and LSTM (Long Short-Term Memory), achieving improved predictive accuracy over traditional methods. These epidemic-informed models benefit from mechanistic insights, enhancing their responsiveness to changing trends. Our results emphasize the importance of timely treatment, hygiene, and vaccination in mitigating mpox spread. The integrated modeling and the forecasting framework provide valuable tools for anticipating outbreaks and informing public health strategies.

猴痘是一种重新出现的病毒性疾病,人类传播日益持续,特别是在以前未受影响的地区。在这项研究中,我们开发了一个隔间流行病模型,捕捉m痘传播动力学,并纳入治疗功能,以评估医疗干预对疾病进展和恢复的影响。该模型使用美国案例数据进行校准,并通过信任区域反射优化方法估计参数,以确保与观察到的趋势密切一致。我们使用偏秩相关系数进行全局敏感性分析,以确定影响传输的关键参数。模型的分岔结构通过基本繁殖数RM0进行检查,揭示了突出阈值行为和复杂地方性动态潜力的前向和后向分岔。对于实时预测,我们将mpox动态的先验知识纳入机器学习模型,ARNN(自回归神经网络),ARIMA(自回归集成移动平均)和LSTM(长短期记忆),实现了比传统方法更高的预测精度。这些了解流行病情况的模型得益于对机制的洞见,增强了它们对变化趋势的反应能力。我们的研究结果强调了及时治疗、卫生和接种疫苗在减轻mpox传播中的重要性。综合建模和预测框架为预测疫情和通报公共卫生战略提供了宝贵的工具。
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引用次数: 0
Hierarchical formation of multicluster and chimera states in a network of phase oscillators with high-order adaptive couplings. 具有高阶自适应耦合的相位振荡器网络中多簇和嵌合状态的分层形成。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0281585
Dmitry V Kasatkin, Vladimir I Nekorkin

In this paper, we study the influence of high-order interactions and coupling adaptivity on the dynamics of coupled oscillators. We found that the introduction of second-order adaptive couplings leads to the emergence of a new type of synchronous behavior in the form of double antipodal clusters, which was not observed in the case of pairwise interactions. We also discovered various scenarios for the emergence of hierarchical synchronization patterns, including multicluster and chimera states. In this case, the process of sequential formation of synchronous groups includes two stages with characteristic properties. The first stage is associated with the emergence in part of the network of a pair of high-frequency and low-frequency synchronous groups, the sizes of which are ordered in a hierarchical way. The emergence of such pairs is accompanied by the suppression of the impact from the rest of the network oscillators and the presence of strong interaction within each pair. During the second stage, the process of synchronization of the remaining incoherent part of the network occurs. Due to high-order interactions, this process is determined by the presence of a complex structure of interactions in the network, which can lead to the emergence of transient synchronous sets.

本文研究了高阶相互作用和耦合自适应对耦合振子动力学的影响。我们发现二阶自适应耦合的引入导致了双对映簇形式的新型同步行为的出现,这在成对相互作用的情况下是没有观察到的。我们还发现了分层同步模式出现的各种场景,包括多集群和嵌合体状态。在这种情况下,同步群的序贯形成过程包括两个具有特征性质的阶段。第一阶段是在部分网络中出现一对高频和低频同步组,其大小按等级顺序排列。这种对的出现伴随着来自网络振荡器其余部分的影响的抑制以及每对内部强相互作用的存在。在第二阶段,对网络中剩余的不相干部分进行同步。由于高阶相互作用,这一过程是由网络中复杂的相互作用结构决定的,这可能导致瞬态同步集的出现。
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引用次数: 0
The effect of the non-linear function on system dynamics within delay-feedback reservoirs. 非线性函数对时滞反馈水库系统动力学的影响。
IF 3.2 2区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2025-11-01 DOI: 10.1063/5.0286757
Alexander C McDonnell, Martin A Trefzer

Delay-feedback reservoirs are a subset of reservoir computers characterized by a hardware-efficient architecture that trades spatial complexity for temporal processing. It employs a single non-linear node, a delay line, and a time-multiplexed input signal to generate a network of "virtual nodes," effectively emulating a larger spatial neural network. One of the most powerful aspects of delay-feedback reservoirs is their versatility. Our previous work found that the non-linear node performs two mathematical functions, a non-linear transform and integration. The non-linear transform can be represented by any number of non-linear functions, making it difficult to optimize a delay-feedback reservoir to solve a specific computational task. This work explores different non-linear functions in order to determine their effect on the dynamics of the reservoir, in order to provide insight into this optimization problem. Five different non-linear functions are compared in terms of performance, metrics, and utilization: Mackey-Glass, sine squared, double sinusoids, Tan, and Tanh. Our results find that the Mackey-Glass non-linear function shows limited system dynamics, performing well on non-linear tasks but performing poorly on memory intensive tasks. We then demonstrate the distinct system dynamics within the other four non-linear functions. We found that sine squared shows limited overall performance, double sinusoid performs well in non-linear tasks, Tan resembles an odd valued exponent Mackey-Glass reservoir but with greater parameter sensitivity, and tanh offers balanced performance across both task types. We find that modifying the system dynamics of a reservoir is an important step toward optimizing a delay-feedback reservoir for specific computational tasks.

延迟反馈水库是水库计算机的一个子集,其特点是硬件高效的体系结构,以空间复杂性为代价进行时间处理。它采用单个非线性节点、延迟线和时间复用输入信号来生成一个“虚拟节点”网络,有效地模拟了一个更大的空间神经网络。延迟反馈储存库最强大的一个方面是它的多功能性。我们之前的工作发现,非线性节点执行两个数学函数,非线性变换和积分。非线性变换可以由任意数量的非线性函数表示,这使得优化延迟反馈存储库以解决特定的计算任务变得困难。这项工作探讨了不同的非线性函数,以确定它们对水库动力学的影响,从而为这一优化问题提供见解。在性能、指标和利用率方面比较了五种不同的非线性函数:Mackey-Glass、正弦平方、双正弦曲线、Tan和Tanh。我们的结果发现,Mackey-Glass非线性函数显示有限的系统动力学,在非线性任务中表现良好,但在内存密集型任务中表现不佳。然后,我们在其他四个非线性函数中展示了不同的系统动力学。我们发现正弦平方显示有限的整体性能,双正弦在非线性任务中表现良好,Tan类似于奇值指数麦基-格拉斯油藏,但具有更高的参数灵敏度,tanh在两种任务类型中提供平衡的性能。我们发现,修改储库的系统动力学是优化特定计算任务的延迟反馈储库的重要一步。
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引用次数: 0
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