The exacerbation of BPSD and psychiatric symptoms seriously affect the quality of life of patients and caregivers, and are also the main target symptoms of drug intervention. Based on recent clinical research results, this article elaborates on the concepts, observations, and evaluations of agitation and psychotic symptoms, with a focus on the basic principles and prescription specifications of drug treatment. The aim is to provide clinical doctors with the latest and applicable information, and help formulators better identify and handle severe neurological and behavioral problems such as agitation in BPSD patients.
{"title":"Drug treatment of psychotic symptoms and agitation behavior in patients with dementia","authors":"Lijun Jiang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.004","url":null,"abstract":"认识痴呆精神行为症状(BPSD)的激越和精神病性症状严重影响患者和照料者的生活质量，也是药物干预的主要靶症状。现结新近的临床研究结果，阐述激越和精神病性症状概念、观察和评估，重点讲述了药物治疗的基本原则和处方规范，旨在为临床医生获得最新的、适用的信息，帮助处方者更好地识别、处理BPSD患者的激越等严重神经精神行为问题。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1210-1212"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41452229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effect of Rosuvastatin on fasting plasma glucose after coronary stent implantation in elderly patients with non-diabetes mellitus. Methods A total of 216 non-diabetic elderly patients undergoing coronary stent implantation in our hospital from November 2015 to April 2018 were enrolled, with a follow-up in the cardiovascular department after discharge from the Hospital.The demographic data, follow-up time, and laboratory results at hospital admission and the last outpatient visit were collected retrospectively. Results At the end of follow-up, Fasting plasma glucose(FPG)was increased in 191 patients with normal baseline FPG level as compared with the baseline level(t=-3.783, P=0.000). The incidence of new-onset diabetes was higher in the pre-diabetes group than in the normal blood glucose group(24.0% vs.2.6%, χ2=16.72, P=0.000). Conclusions Rosuvastatin increases fasting blood glucose levels in elderly non-diabetic patients after coronary stent implantation.Pre-diabetes may increase the risk for rosuvastatin-associated new-onset diabetes. Key words: Coronary artery disease; Blood glucose
{"title":"Effect of Rosuvastatin on fasting plasma glucose after coronary stent implantation in elderly patients","authors":"Fangfang Wu, Xiaoyan Zhao, Jin-li Zhang, Zhengrong Li, Yuqiang Wang, Tao Tian","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.006","url":null,"abstract":"Objective \u0000To investigate the effect of Rosuvastatin on fasting plasma glucose after coronary stent implantation in elderly patients with non-diabetes mellitus. \u0000 \u0000 \u0000Methods \u0000A total of 216 non-diabetic elderly patients undergoing coronary stent implantation in our hospital from November 2015 to April 2018 were enrolled, with a follow-up in the cardiovascular department after discharge from the Hospital.The demographic data, follow-up time, and laboratory results at hospital admission and the last outpatient visit were collected retrospectively. \u0000 \u0000 \u0000Results \u0000At the end of follow-up, Fasting plasma glucose(FPG)was increased in 191 patients with normal baseline FPG level as compared with the baseline level(t=-3.783, P=0.000). The incidence of new-onset diabetes was higher in the pre-diabetes group than in the normal blood glucose group(24.0% vs.2.6%, χ2=16.72, P=0.000). \u0000 \u0000 \u0000Conclusions \u0000Rosuvastatin increases fasting blood glucose levels in elderly non-diabetic patients after coronary stent implantation.Pre-diabetes may increase the risk for rosuvastatin-associated new-onset diabetes. \u0000 \u0000 \u0000Key words: \u0000Coronary artery disease; Blood glucose","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1216-1219"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42794796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.11.022
Wenping Peng, Shun Huang, Ning Yang
Objective To observe whether the active forced-air warming has the same efficacy on the prevention of perioperative hypothermia in the elderly as compared with young patients. Methods This was a prospective, randomized, controlled clinical trial.Forty patients scheduled for abdominal surgery under general anesthesia were allocated to two groups: the elderly group and the young group(n=20, each). All patients received active forced-air warming at 20-30 min before induction of anaesthesia till leaving the operation room.Blood products and peritoneal lavage fluids were warmed to 37℃, and other intravenous fluids were at room-temperature.The core temperatures were recorded after entering the operation room(baseline), before induction of anaesthesia, at 15 min intervals after induction of anaesthesia, at the end of surgery and before leaving the operation room.The postoperative shivering and adverse reactions were also recorded. Results The core temperature was lower in elderly patients than in young patients at baseline and at each time points after 30 min of induction of anaesthesia(P<0.05). In elderly patients, the core temperature was significantly lower before leaving operation room than at the baseline(t=2.353, P=0.03), but in young patients, no significant difference was found in the core temperature between at the baseline and before leaving operation room(t=0.233, P=0.818). The incidence of intra-operative hypothermia was higher in elderly patients than in young patients(40.0% or 8/20 vs.5.0% or 1/20, c2=7.025, P=0.008). Conclusions During abdominal surgery under general anesthesia, active forced-air warming cannot effectively prevent perioperative hypothermia in elderly patients as compared with young patients. Key words: Anesthesia, general; Body temperature regulation
{"title":"Comparison of efficacy of active forced-air warming for preventing perioperative hypothermia between the elderly and young patients","authors":"Wenping Peng, Shun Huang, Ning Yang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.022","url":null,"abstract":"Objective \u0000To observe whether the active forced-air warming has the same efficacy on the prevention of perioperative hypothermia in the elderly as compared with young patients. \u0000 \u0000 \u0000Methods \u0000This was a prospective, randomized, controlled clinical trial.Forty patients scheduled for abdominal surgery under general anesthesia were allocated to two groups: the elderly group and the young group(n=20, each). All patients received active forced-air warming at 20-30 min before induction of anaesthesia till leaving the operation room.Blood products and peritoneal lavage fluids were warmed to 37℃, and other intravenous fluids were at room-temperature.The core temperatures were recorded after entering the operation room(baseline), before induction of anaesthesia, at 15 min intervals after induction of anaesthesia, at the end of surgery and before leaving the operation room.The postoperative shivering and adverse reactions were also recorded. \u0000 \u0000 \u0000Results \u0000The core temperature was lower in elderly patients than in young patients at baseline and at each time points after 30 min of induction of anaesthesia(P<0.05). In elderly patients, the core temperature was significantly lower before leaving operation room than at the baseline(t=2.353, P=0.03), but in young patients, no significant difference was found in the core temperature between at the baseline and before leaving operation room(t=0.233, P=0.818). The incidence of intra-operative hypothermia was higher in elderly patients than in young patients(40.0% or 8/20 vs.5.0% or 1/20, c2=7.025, P=0.008). \u0000 \u0000 \u0000Conclusions \u0000During abdominal surgery under general anesthesia, active forced-air warming cannot effectively prevent perioperative hypothermia in elderly patients as compared with young patients. \u0000 \u0000 \u0000Key words: \u0000Anesthesia, general; Body temperature regulation","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1282-1284"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46897537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.11.007
Li Feixiang, Zhao Yang
Objective To investigate characteristics of intestinal flora in elderly patients with coronary heart disease (CHD) versus CHD plus complicated heart failure (HF). Methods The 80 CHD patients admitted into our hospital from April 2017 to April 2018 were consecutively enrolled in this prospective study.They were divided into the CHD group (without HF, n=40) and the HF group (CHD plus HF, n=40), and 40 healthy elderly people taking health examination during the same period were considered as the control group.The 0.5 g stool specimen from each observer was collected.The specific DNA fragments of 16S rDNA/18S rDNA/ITS/ function genes were amplified, the Polymerase Chain reaction(PCR)amplified products were sequenced by Illumina Genome Analyzer IIx.And the sequencing results were followed by Read splicing, OTU clustering, alpha diversity analysis and species diversity analysis.Finally, the sample species information was obtained. Results The mean abundances of gut microflora in CHD group and in HF group were lower than in control group (P<0.05). The abundance of phylum bacteroidetes was higher in the control group (66.41±3.25)% than in the CHD group (45.21±9.07)% and in HF groups (27.29±13.27)%(P<0.05). And the abundance of phylum firmicutes was lower in the control group than in the CHD and HF groups (P<0.05). LEfSe analysis showed that the flora with high abundances in the healthy elderly group were mainly Bacteroides, Bacteroidia and Bacteroidales.Ruminococcus and Clostridium occurred mainly in the CHD group, and Firmicutes and Enterobacte occurred mainly in CHD plus heart failure group. Conclusions The intestinal flora disturbance occurs in elderly patients with coronary heart disease or CHD with heart failure. Key words: Coronary artery disease; Heart failure; Bacteria; Gastrointestinal tract
{"title":"Characteristics of intestinal flora in the elderly patients with coronary heart disease versus coronary heart disease-complicated heart failure","authors":"Li Feixiang, Zhao Yang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.007","url":null,"abstract":"Objective \u0000To investigate characteristics of intestinal flora in elderly patients with coronary heart disease (CHD) versus CHD plus complicated heart failure (HF). \u0000 \u0000 \u0000Methods \u0000The 80 CHD patients admitted into our hospital from April 2017 to April 2018 were consecutively enrolled in this prospective study.They were divided into the CHD group (without HF, n=40) and the HF group (CHD plus HF, n=40), and 40 healthy elderly people taking health examination during the same period were considered as the control group.The 0.5 g stool specimen from each observer was collected.The specific DNA fragments of 16S rDNA/18S rDNA/ITS/ function genes were amplified, the Polymerase Chain reaction(PCR)amplified products were sequenced by Illumina Genome Analyzer IIx.And the sequencing results were followed by Read splicing, OTU clustering, alpha diversity analysis and species diversity analysis.Finally, the sample species information was obtained. \u0000 \u0000 \u0000Results \u0000The mean abundances of gut microflora in CHD group and in HF group were lower than in control group (P<0.05). The abundance of phylum bacteroidetes was higher in the control group (66.41±3.25)% than in the CHD group (45.21±9.07)% and in HF groups (27.29±13.27)%(P<0.05). And the abundance of phylum firmicutes was lower in the control group than in the CHD and HF groups (P<0.05). LEfSe analysis showed that the flora with high abundances in the healthy elderly group were mainly Bacteroides, Bacteroidia and Bacteroidales.Ruminococcus and Clostridium occurred mainly in the CHD group, and Firmicutes and Enterobacte occurred mainly in CHD plus heart failure group. \u0000 \u0000 \u0000Conclusions \u0000The intestinal flora disturbance occurs in elderly patients with coronary heart disease or CHD with heart failure. \u0000 \u0000 \u0000Key words: \u0000Coronary artery disease; Heart failure; Bacteria; Gastrointestinal tract","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1220-1222"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43489660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.11.018
Jian Feng, N. Cui
Objective To compare the clinical effects among single-incision laparoscopic appendectomy(SILA), laparoscopic appendectomy(LA)and open appendectomy(OA)in the treatment of elderly patients with acute appendicitis. Methods A total of 98 consecutive elderly patients undergoing appendectomy in our hospital from November 2014 to December 2016 were retrospectively selected.Among them, 31 patients underwent SILA, 35 underwent LA and 32 underwent OA.The operation time, the first exhaust time after operation, length of hospital stay, Numerical Rating Scale(NRS)pain score, wound infection rate and incidence of postoperative complications were compared between the three groups. Results The postoperative venting time and length of hospital stay were shorter, NRS was less, wound infection rate and incidence of postoperative complications were lower in the SILA and LA groups than in the OA group[(21.5±5.2) h, (22.1±5.4) h vs.(24.8±5.8) h, (4.5±1.3) d, (4.8±1.4) d vs.(9.4±1.5) d, (3.7±0.5), (4.1±0.7) vs. (6.3±0.9), 0%, 0% vs. 12.5%, 9.7% or 3/31, 14.3% or 5/35 vs. 43.8% or 14/32, respectively, P<0.05), while the operative time was less in the LA and OA groups than in the SILA group(45.4±10.5) min, (48.6±1.4) min vs.(73.2±12.3)min, P<0.05). The incision NRS pain score was lower in the SILA group than in the LA and OA groups(3.7±0.5 in SILA vs.4.1±0.7 in LA vs. 6.3±0.9 in OA, P<0.05). Conclusions LA has advantages of less trauma, less pain, quicker recovery, fewer complications and beautiful incisions.SILA has less pain than LA, but needs longer operative time.SILA is worthy of promotion in the treatment of acute appendicitis especially in the elderly, but still needs further improvement. Key words: Appendicitis; Laparoscope; Appendectomy
{"title":"Comparison of the clinical effects among single-incision laparoscopic appendectomy, laparoscopic appendectomy and open appendectomy in elderly patients with acute appendicitis","authors":"Jian Feng, N. Cui","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.018","url":null,"abstract":"Objective \u0000To compare the clinical effects among single-incision laparoscopic appendectomy(SILA), laparoscopic appendectomy(LA)and open appendectomy(OA)in the treatment of elderly patients with acute appendicitis. \u0000 \u0000 \u0000Methods \u0000A total of 98 consecutive elderly patients undergoing appendectomy in our hospital from November 2014 to December 2016 were retrospectively selected.Among them, 31 patients underwent SILA, 35 underwent LA and 32 underwent OA.The operation time, the first exhaust time after operation, length of hospital stay, Numerical Rating Scale(NRS)pain score, wound infection rate and incidence of postoperative complications were compared between the three groups. \u0000 \u0000 \u0000Results \u0000The postoperative venting time and length of hospital stay were shorter, NRS was less, wound infection rate and incidence of postoperative complications were lower in the SILA and LA groups than in the OA group[(21.5±5.2) h, (22.1±5.4) h vs.(24.8±5.8) h, (4.5±1.3) d, (4.8±1.4) d vs.(9.4±1.5) d, (3.7±0.5), (4.1±0.7) vs. (6.3±0.9), 0%, 0% vs. 12.5%, 9.7% or 3/31, 14.3% or 5/35 vs. 43.8% or 14/32, respectively, P<0.05), while the operative time was less in the LA and OA groups than in the SILA group(45.4±10.5) min, (48.6±1.4) min vs.(73.2±12.3)min, P<0.05). The incision NRS pain score was lower in the SILA group than in the LA and OA groups(3.7±0.5 in SILA vs.4.1±0.7 in LA vs. 6.3±0.9 in OA, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000LA has advantages of less trauma, less pain, quicker recovery, fewer complications and beautiful incisions.SILA has less pain than LA, but needs longer operative time.SILA is worthy of promotion in the treatment of acute appendicitis especially in the elderly, but still needs further improvement. \u0000 \u0000 \u0000Key words: \u0000Appendicitis; Laparoscope; Appendectomy","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1266-1269"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43832117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of transverse colon artery malformation with multiple digestive tract diseases","authors":"Li Zhang, G. Shi, Lianguo Fu","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.027","url":null,"abstract":"胃肠道血管畸形(GIVM)是胃肠道常见的血管异常病变，表现为管壁变薄、血管扩张，病变可位于整个肠道，以胃、十二指肠、右半结肠和小肠多见，以横结肠动脉畸形破裂出血的病例报道较少见。本文报道1例横结肠动脉畸形合并多种消化道疾病的老年患者临床资料及经验教训，结合文献分析横结肠动脉畸形在对该类患者进行诊疗过程中的影响及预后。患者经局部金属钛夹止血后疗效显著。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1304-1306"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48571037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.11.014
Yanan Wei, L. Deng
Objective To investigate the correlation between nonalcoholic fatty liver disease(NAFLD)fibrosis score(NFS)and unstable plaques of carotid in elderly NAFLD patients. Methods The clinical and carotid plaques data of 191 elderly(≥60 years old)admitted into our department between July 2016 and January 2018 were retrospectively collected.With NFS 0.676 as a cut-off point, the patients were divided into a liver fibrosis group(NFS ≥0.676, n=65)and a non-liver fibrosis group(NFS<0.676, n=126). Based on quartiles of NFS, the patients were divided into four groups: the Q1 group(NFS<-0.865, n=48), the Q2 group(-0.865≤NFS<0.100, n=48), the Q3 group(0.1≤NFS<1.070, n=47), the Q4 group(NFS≥1.070, n=48). The correlation of NFS with the property of carotid plaques was analyzed. Results The detection rate of unstable carotid plaques was increased along with the increase of NFS(F=8.573, P=0.004). The detection rate of unstable carotid plaques was higher in the liver fibrosis group than in the non-liver fibrosis group(78.5% or 51/65 vs.60.3% or 76/126, χ2=5.883, P=0.015). Multiple logistic regression analysis showed that liver fibrosis(NFS≥0.676)was independently correlated with unstable carotid plaques(β=0.816, 95%CI: 1.110~4.607, OR=2.261, P=0.025)after adjusting for possible confounding factors including age, gender, diabetes mellitus, hypertension, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein. Conclusions NFS is correlated with unstable carotid plaques in elderly NAFLD patients, and the higher NFS is the independent risk factor for unstable carotid plaques for elderly NAFLD patients with NFS higher than 0.676.We should pay more attention to the evaluation of unstable carotid plaques. Key words: Fatty liver; Liver cirrhosis; Carotid arteries
{"title":"Correlation between nonalcoholic fatty liver disease fibrosis score and unstable plaques of carotid in elderly patients with nonalcoholic fatty liver disease","authors":"Yanan Wei, L. Deng","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.014","url":null,"abstract":"Objective \u0000To investigate the correlation between nonalcoholic fatty liver disease(NAFLD)fibrosis score(NFS)and unstable plaques of carotid in elderly NAFLD patients. \u0000 \u0000 \u0000Methods \u0000The clinical and carotid plaques data of 191 elderly(≥60 years old)admitted into our department between July 2016 and January 2018 were retrospectively collected.With NFS 0.676 as a cut-off point, the patients were divided into a liver fibrosis group(NFS ≥0.676, n=65)and a non-liver fibrosis group(NFS<0.676, n=126). Based on quartiles of NFS, the patients were divided into four groups: the Q1 group(NFS<-0.865, n=48), the Q2 group(-0.865≤NFS<0.100, n=48), the Q3 group(0.1≤NFS<1.070, n=47), the Q4 group(NFS≥1.070, n=48). The correlation of NFS with the property of carotid plaques was analyzed. \u0000 \u0000 \u0000Results \u0000The detection rate of unstable carotid plaques was increased along with the increase of NFS(F=8.573, P=0.004). The detection rate of unstable carotid plaques was higher in the liver fibrosis group than in the non-liver fibrosis group(78.5% or 51/65 vs.60.3% or 76/126, χ2=5.883, P=0.015). Multiple logistic regression analysis showed that liver fibrosis(NFS≥0.676)was independently correlated with unstable carotid plaques(β=0.816, 95%CI: 1.110~4.607, OR=2.261, P=0.025)after adjusting for possible confounding factors including age, gender, diabetes mellitus, hypertension, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein. \u0000 \u0000 \u0000Conclusions \u0000NFS is correlated with unstable carotid plaques in elderly NAFLD patients, and the higher NFS is the independent risk factor for unstable carotid plaques for elderly NAFLD patients with NFS higher than 0.676.We should pay more attention to the evaluation of unstable carotid plaques. \u0000 \u0000 \u0000Key words: \u0000Fatty liver; Liver cirrhosis; Carotid arteries","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1251-1253"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46313857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.11.013
Cuiping Zhou, Jiaqi Liu, D. Gao, Fang Liu
Objective To observe the effects of probiotics on gut microecology, immune function, and inflammatory index in patients with critical cerebral infarction. Methods A total of 70 patients with critical cerebral infarction treated in our hospital from January 2015 to January 2019 were retrospectively studied.They were randomly divided into a control group(n=35)receiving routine treatment and an observation group(n=35)receiving routine treatment added to capules containing live Bifidobacterium, Lactobacillus, and Enterococcus for 4 weeks.The changes of gut microflora, immune function and inflammatory index were compared between the two groups. Results The number of Bifidobacterium, Lactobacillus, and Enterococcus colonies were significantly increased and the colony count of yeast was decreased in the observation group after treatment versus pre-treatment(P 0.05). The level of CD4+ and CD4+/CD8+ ratio were significantly higher in observation group than in the control group(P<0.05), and the level of CD8+ was lower in observation than in the control group(P<0.05)after treatment.The levels of hemoglobin(Hb), total protein(TP), albumin(Alb), interleukin(IL)-6 and tumor necrosis factor(TNF)were decreased in the two groups, but the decrement of the levelsof IL-6 and TNF was more marked in the observation group than in the control group(P<0.05), However, the levels of Hb, TP, A1b in the observation group were lower tan those in te control group(all P<0.05). Conclusions Probiotics can significantly improve the intestinal flora and immune function, release the deterioration of nutritional status, and inhibit the inflammatory response in patients with critical cerebral infarction, which is worthy of clinical promotion. Key words: Brain infarction; Immune function; Inflammation
{"title":"Effects of probiotics on gut microflora, immune function and inflammatory index in patients with critical cerebral infarction","authors":"Cuiping Zhou, Jiaqi Liu, D. Gao, Fang Liu","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.013","url":null,"abstract":"Objective \u0000To observe the effects of probiotics on gut microecology, immune function, and inflammatory index in patients with critical cerebral infarction. \u0000 \u0000 \u0000Methods \u0000A total of 70 patients with critical cerebral infarction treated in our hospital from January 2015 to January 2019 were retrospectively studied.They were randomly divided into a control group(n=35)receiving routine treatment and an observation group(n=35)receiving routine treatment added to capules containing live Bifidobacterium, Lactobacillus, and Enterococcus for 4 weeks.The changes of gut microflora, immune function and inflammatory index were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The number of Bifidobacterium, Lactobacillus, and Enterococcus colonies were significantly increased and the colony count of yeast was decreased in the observation group after treatment versus pre-treatment(P 0.05). The level of CD4+ and CD4+/CD8+ ratio were significantly higher in observation group than in the control group(P<0.05), and the level of CD8+ was lower in observation than in the control group(P<0.05)after treatment.The levels of hemoglobin(Hb), total protein(TP), albumin(Alb), interleukin(IL)-6 and tumor necrosis factor(TNF)were decreased in the two groups, but the decrement of the levelsof IL-6 and TNF was more marked in the observation group than in the control group(P<0.05), However, the levels of Hb, TP, A1b in the observation group were lower tan those in te control group(all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Probiotics can significantly improve the intestinal flora and immune function, release the deterioration of nutritional status, and inhibit the inflammatory response in patients with critical cerebral infarction, which is worthy of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Brain infarction; Immune function; Inflammation","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1247-1250"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49319754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship of common mood and behavioral symptoms with cognitive disorders in the elderly: Latest research progression","authors":"Huali Wang, N. Zhang, Xiancang Ma, Heng-ge Xie, Xin-yu Yu","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.11.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.11.003","url":null,"abstract":"老年人焦虑、睡眠紊乱更倾向于认知障碍风险因素，而淡漠、抑郁情绪倾向于认知障碍早期症状。对于出现这些常见情绪行为症状的老年人群，需关注其认知功能的评估和随访，了解认知行为变化规律，以期及时、有效识别认知下降情况，这对于老年人群认知障碍早期预防具有重要的临床意义。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1205-1209"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47138230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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