Brain Behavior and Immunity Integrative最新文献

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Does lateral habenula mediate effects of gestational stress on rat maternal behavior? 外侧缰核介导妊娠应激对大鼠母性行为的影响吗？

Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01 DOI: 10.1016/j.bbii.2024.100098

Bo Wang , Ming Li

This exploratory study investigated the neural substrate underlying the effect of gestational stress on rat maternal behavior. We tested the hypothesis that the lateral habenula (LHb)-centered neural circuitry (e.g., raphe, ventral tegmental area, nucleus accumbens, etc.) mediates the maternal disruptive effect of gestational stress. Pregnant Sprague-Dawley rats were subjected to daily 30-min restraining stress from approximately gestation day (GD) 5 to 21, white noise from GD 5 to 12 and mild foot shock from GD 13 to 21. Maternal behavior in the home cage and pup retrieval on an elevated plus maze (EPM) were observed during the first postpartum week. The gestational stress reduced body weight gain of stressed females, and reduced time that they spent outside of the nest, a sign of increased maternal anxiety and hypervigilant parenting style. On the open arms of EPM, the stressed dams showed higher frequently sniffing pups than non-stressed ones. Testing with pups (pup exposure) on the EPM decreased c-Fos expression in the LHb in the non-stressed control dams, but it increased c-Fos expression in the dorsal and medial raphe regions of the control dams. Gestational stress reduced this pup effect in all three regions, implying that gestational stress attenuated the ability of pup exposure to activate the maternally relevant brain regions. Our findings indicate that gestational stress may act upon the LHb (as a putative center that mediates negative emotion) and its downstream projection sites (i.e., dorsal and median raphe) to compromise the quality of maternal care.

本研究旨在探讨妊娠应激对母性行为影响的神经机制。我们验证了以外侧链（LHb）为中心的神经回路（如中缝、腹侧被盖区、伏隔核等）介导妊娠应激对母体的破坏性影响的假设。妊娠大鼠从妊娠第5 ~ 21天开始，每天施加30 min的抑制应激，在妊娠第5 ~ 12天施加白噪声，在妊娠第13 ~ 21天施加轻度足部电击。在产后第一周，观察母鼠在家中笼中的行为和幼犬在高架迷宫（EPM）上的恢复。孕期压力降低了压力大的雌鸟的体重增加，减少了它们在巢外的时间，这是母性焦虑增加和过度警惕的育儿方式的一个迹象。在张开的EPM臂上，有压力的水坝比没有压力的水坝更频繁地嗅探幼崽。实验结果表明，EPM降低了非应激对照坝LHb中c-Fos的表达，但增加了对照坝中缝背区和中缝区c-Fos的表达。妊娠应激降低了这三个区域对幼犬的影响，这意味着妊娠应激减弱了幼犬暴露激活与母体相关的大脑区域的能力。我们的研究结果表明，妊娠应激可能作用于下丘脑（作为一个假定的负性情绪中介中心）及其下游投射部位（即中缝背侧和中缝中侧），从而影响产妇护理的质量。

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Editorial summary: Perinatal stress, inflammation, and maternal-child mental health 编辑摘要：围产期压力、炎症和母婴心理健康

Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01 DOI: 10.1016/j.bbii.2025.100106

Ming Li, Xingshun Xu, Zhongliang Zhu, Weiwen Wang

This edition focuses on the intricate relationship between stress and inflammation during the perinatal period and their impact on the mental health of mothers and children. The scientific contributions of seven research papers and reviews are collated in this special issue, offering valuable insights into how perinatal stress impacts maternal and child mental health via various mechanisms, with a special focus on the inflammatory signal pathways. It also highlights the importance of early intervention strategies and novel therapeutic approaches to mitigate the adverse consequences of perinatal stress.

本版着重于围产期压力和炎症之间的复杂关系及其对母亲和儿童心理健康的影响。本特刊整理了七篇研究论文和综述的科学贡献，为围产期压力如何通过各种机制影响孕产妇和儿童的心理健康提供了宝贵的见解，特别关注炎症信号通路。它还强调了早期干预策略和新的治疗方法的重要性，以减轻围产期压力的不良后果。

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Maternal social isolation during pre-conception and pregnancy programs inflammatory markers and biobehavioural aging trajectories in distant F4 offspring 母体在孕前和妊娠期的社会隔离，远缘F4后代的炎症标志物和生物行为老化轨迹

Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01 DOI: 10.1016/j.bbii.2025.100104

Mirela Ambeskovic , Sorina Truica , J. Keiko McCreary , Jamshid Faraji , Xin Fang , David M. Olson , Gerlinde A.S. Metz

Social isolation and loneliness during pre-conception and pregnancy can negatively impact maternal and offspring health. Here we report that maternal social isolation prior to and during pregnancy generates a distinct physiological and behavioural phenotype in 4th generation great-great-grandoffspring. Male and female F4 offspring born to lineages of transgenerational prenatal stress (TPS, where the F0 mother was socially isolated before and during pregnancy), multigenerational prenatal stress (MPS, where gestational isolation occurred in four consecutive generations), and group-housed controls were tested at 6, 12 and 18 months of age. Assessments included endocrine (corticosterone) and immune markers (IL-18, MCP-1 and M-CSF), motor and cognitive function, and brain morphology via in vivo magnetic resonance imaging (MRI) across the lifespan. Ancestral social isolation in F4 generation rats exacerbated aging-associated stress responses and elevated the production of proinflammatory cytokines and chemokines across all groups. Exploratory behaviours, skilled reaching, skilled walking, spatial learning and memory revealed a stress-sensitive phenotype in TPS males and females along with greater hippocampal and prefrontal cortex atrophy. Thus, maternal social isolation mainly represents a stressful challenge with lifelong consequences for future generations. By contrast, MPS females revealed superior reaching skills that indicate behavioural flexibility with adaptive benefits. The MPS model therefore allows interpretations about the origins of resilience in the face of ongoing stress. Both TPS and MPS shifted cognitive strategies indicative of accelerated aging. Thus, social isolation potentially has adverse long-term consequences for future generations. These findings provide a conceptual framework for better risk prediction and prevention of developmental disabilities and aging-related disorders.

孕前和怀孕期间的社会孤立和孤独会对孕产妇和后代的健康产生负面影响。在这里，我们报告了母亲在怀孕前和怀孕期间的社会隔离在第四代高曾孙中产生了独特的生理和行为表型。在6个月、12个月和18个月大的时候，对来自跨代产前压力谱系（TPS， F0母亲在怀孕前和怀孕期间被社会隔离）、多代产前压力谱系（MPS，连续四代发生妊娠隔离）和群体饲养对照组的雄性和雌性F4后代进行了测试。评估包括内分泌（皮质酮）和免疫标志物（IL-18， MCP-1和M-CSF），运动和认知功能，以及通过体内磁共振成像（MRI）在整个生命周期内的脑形态。F4代大鼠的祖先社会隔离加剧了衰老相关的应激反应，并增加了所有组中促炎细胞因子和趋化因子的产生。探索性行为、熟练的伸手、熟练的行走、空间学习和记忆显示，TPS男性和女性的压力敏感表型以及更大的海马和前额叶皮层萎缩。因此，母亲的社会孤立主要是对后代产生终生影响的压力挑战。相比之下，MPS女性表现出优越的接触技能，表明行为灵活性和适应性利益。因此，MPS模型可以解释面对持续压力时恢复力的起源。TPS和MPS都改变了认知策略，表明衰老加速。因此，社会孤立可能对子孙后代产生不利的长期后果。这些发现为更好地预测和预防发育障碍和衰老相关疾病提供了一个概念框架。

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Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01

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Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01

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Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01

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Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01

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Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01

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Prevention and early intervention strategies for perinatal mental health disorders mediated by neuroimmune modulation and anti-inflammatory mechanisms through non-invasive transcranial magnetic stimulation: A narrative review 无创经颅磁刺激介导的神经免疫调节和抗炎机制对围产期心理健康障碍的预防和早期干预策略：综述

Brain Behavior and Immunity Integrative

Pub Date : 2025-01-01 DOI: 10.1016/j.bbii.2025.100103

Yoshihiro Noda , Shinichiro Nakajima

Perinatal mental health disorders, including postpartum depression (PPD), affect approximately 20 % of females during pregnancy and the postpartum period; however, are often undiagnosed and untreated. Traditional treatments, such as antidepressants, have limitations, particularly in terms of safety and efficacy during pregnancy. Recent advancements in brain stimulation therapies, such as repetitive transcranial magnetic stimulation (rTMS), offer promising non-invasive alternatives that may be safer and more effective in treating PPD. rTMS therapy uses magnetic pulses to stimulate the brain areas associated with psychiatric disorders without systemic side effects or the need for anesthesia, making it safe for pregnant patients. This review aims to provide a narrative overview of the potential of rTMS neuromodulation from a neuroimmune–neuroendocrine–neuroinflammatory perspective with a focus on perinatal depression. rTMS exerts its antidepressant effects by indirectly modulating neuroimmune and anti-inflammatory processes, with few maternal side effects and no fetal risks, as is common with pharmacotherapy. Perinatal mental health disorders may arise from abnormalities in the inflammatory and immune system homeostasis, which are influenced by hormonal changes during the perinatal period. Neuroinflammation, driven by cytokines and immune cells crossing the blood–brain barrier, plays a significant role. The interaction between the central and peripheral nervous systems is crucial for neuroinflammation and immune responses. The neurotransmitters produced by neurons and immune cells regulate the immune responses and inflammation, emphasizing the importance of neuroendocrine–immune system interactions. Immune-mediated inflammatory diseases cause chronic inflammation due to the dysregulation of the immune response, affecting the central nervous system in conditions such as perinatal depression or long COVID (post-COVID-19 syndrome). rTMS therapy can potentially reduce or ameliorate the pathophysiology of neurological and neuropsychiatric disorders by modulating the neuroimmune interactions, reducing inflammation, and promoting neuronal protection and repair, thereby highlighting its potential for managing neuroinflammation and related symptoms.

围产期精神健康障碍，包括产后抑郁症（PPD），影响到怀孕和产后期间约20% %的女性；然而，这些疾病往往没有得到诊断和治疗。传统的治疗方法，如抗抑郁药，有局限性，特别是在怀孕期间的安全性和有效性方面。脑刺激疗法的最新进展，如重复经颅磁刺激（rTMS），为治疗PPD提供了有希望的非侵入性替代方法，可能更安全、更有效。rTMS疗法使用磁脉冲刺激与精神疾病相关的大脑区域，没有全身副作用，也不需要麻醉，对孕妇来说是安全的。这篇综述旨在从神经免疫-神经内分泌-神经炎症的角度对rTMS神经调节的潜力进行概述，重点是围产期抑郁症。rTMS通过间接调节神经免疫和抗炎过程发挥其抗抑郁作用，与药物治疗一样，对母体几乎没有副作用，也没有胎儿风险。围产期心理健康障碍可能是由围产期激素变化影响的炎症和免疫系统稳态异常引起的。由细胞因子和免疫细胞穿过血脑屏障驱动的神经炎症起着重要作用。中枢和外周神经系统之间的相互作用对神经炎症和免疫反应至关重要。神经元和免疫细胞产生的神经递质调节免疫反应和炎症，强调神经内分泌-免疫系统相互作用的重要性。免疫介导的炎症性疾病由于免疫反应失调而引起慢性炎症，在围产期抑郁症或长COVID （COVID-19后综合征）等情况下影响中枢神经系统。rTMS疗法可以通过调节神经免疫相互作用，减少炎症，促进神经元保护和修复，从而潜在地减少或改善神经和神经精神疾病的病理生理，从而突出其管理神经炎症和相关症状的潜力。

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