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Qigong exercise and cognitive function in brain imaging studies: A systematic review of randomized controlled trials in healthy and cognitively impaired populations 气功锻炼和脑成像研究中的认知功能:对健康和认知障碍人群随机对照试验的系统回顾
Pub Date : 2023-07-01 DOI: 10.1016/j.bbii.2023.100016
Jianghong Liu , Haoer Shi , Tatia M.C. Lee

Objective

Cognitive decline can significantly affect individuals’ overall health and well-being. While Qigong may hold promise as an intervention strategy, the underlying brain mechanisms of its beneficial effects remain unclear, particularly in cognitively impaired (CI) populations. This systematic review aims to investigate Qigong-induced brain changes and their associations with cognitive functions in both healthy and CI populations. It further seeks to identify potential consistent or divergent brain change patterns across these populations.

Methods

Five English databases PubMed, Cochrane Library, EMBASE, Web of Science, PsycINFO, and 2 Chinese databases Wanfang and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled trial (RCT) studies with Qigong intervention and brain imaging outcomes from inception to March 2023. The quality of included studies was evaluated according to the Cochrane Collaboration’s risk of bias tool.

Results

A total of 18 studies from 9 RCTs were included in this review. The results indicated that Qigong induced various structural and functional changes in multiple brain regions, including the frontal lobe, hippocampus and temporal gyrus, anterior cingulate cortex (ACC), insula, putamen, and caudate, among others. Within the brain changes, the prefrontal cortex and hippocampus were consistently reported across healthy and CI populations and were found to be associated with various cognitive functions.

Conclusions

Qigong exercise leads to diverse brain changes, with the alterations in hippocampus and prefrontal cortex likely contributing to its cognitive benefits. These findings provide support for the effectiveness of Qigong as a cognitive intervention.

认知能力下降会显著影响个体的整体健康和幸福感。虽然气功可能有望成为一种干预策略,但其有益作用的潜在大脑机制仍不清楚,尤其是在认知障碍人群中。这篇系统综述旨在研究气功引起的大脑变化及其与健康人群和CI人群认知功能的关系。它进一步试图确定这些人群中潜在的一致或不同的大脑变化模式。方法检索5个英文数据库PubMed、Cochrane Library、EMBASE、Web of Science、PsycINFO,以及2个中文数据库Wanfang和中国知网(CNKI),从开始到2023年3月进行气功干预和脑成像结果的随机对照试验(RCT)研究。纳入研究的质量根据Cochrane协作的偏倚风险工具进行评估。结果本综述共纳入9项随机对照试验的18项研究。结果表明,气功可引起大脑多个区域的各种结构和功能变化,包括额叶、海马和颞回、前扣带皮层(ACC)、脑岛、壳核和尾状核等。在大脑变化中,健康人群和CI人群中一致报告了前额叶皮层和海马体,并发现它们与各种认知功能有关。结论气功运动会导致不同的大脑变化,海马和前额叶皮层的变化可能是其认知益处的原因之一。这些发现为气功作为一种认知干预的有效性提供了支持。
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引用次数: 1
A quality improvement study on the feasibility and potential benefits of a yogic breathing program for cancer survivors and caregivers during treatment in a lodging facility 在住宿设施治疗期间,对癌症幸存者和护理人员进行瑜伽呼吸计划的可行性和潜在益处的质量改进研究
Pub Date : 2023-07-01 DOI: 10.1016/j.bbii.2023.100019
Christina M. Alford , Amy E. Wahlquist , Katherine R. Sterba , Graham W. Warren , Sundaravadivel Balasubramanian

Background

Complementary and integrative health approaches with a focus on relieving side effects of cancer treatment are popular among cancer patients. Previous studies have investigated the combined effects of yoga postures, breathing, and meditation, but the specific effects of the breathing component are under-reported. Our previous studies indicate that yogic breathing can improve salivary biomarker expression related to stress, immune response, and tumor suppression. We aim to assess the acceptability and feasibility of a yogic breathing program in cancer patients and caregivers during the treatment period.

Methods

In this quality improvement study, we designed a 20-minute yogic breathing regimen and introduced them to all-site cancer patients and their caregivers during the cancer treatment period at a lodging facility, Hope Lodge in Charleston, SC. All interested participants were included as there were no eligibility criteria set for the study. The availability of the class was advertised via intercom, displays, and word of mouth. Participants were taught five different breathing exercises, and after completion of the exercises in a single session, a self-reported quality improvement questionnaire was administered assessing sociodemographic/clinical factors, expectations about the session, and ratings of satisfaction with the session.

Results

During the nine months of the data collection period, 52 participants provided feedback of which patients and caregivers were almost equal numbers. Participants’ perception of intervention acceptance, symptom management, satisfaction with the sessions, and future needs for practice indicate that the yogic breathing sessions help improve some of the key symptoms of cancer experience such as stress.

Conclusion

Findings indicate that yogic breathing is acceptable to patients and caregivers and may help alleviate some of the side effects resulting from cancer treatment, and the intervention is feasible at lodging facilities during treatment. Currently, the yogic breathing sessions are conducted on a weekly basis by Hope Lodge volunteers trained by the study team.

背景以减轻癌症治疗的副作用为重点的补充和综合健康方法在癌症患者中很流行。先前的研究已经调查了瑜伽姿势、呼吸和冥想的综合影响,但呼吸成分的具体影响还没有得到充分报道。我们之前的研究表明,瑜伽呼吸可以改善与压力、免疫反应和肿瘤抑制相关的唾液生物标志物表达。我们旨在评估癌症患者和护理人员在治疗期间瑜伽呼吸计划的可接受性和可行性。方法在这项质量改进研究中,我们设计了一种20分钟的瑜伽呼吸方案,并将其介绍给癌症治疗期间在南卡罗来纳州查尔斯顿Hope Lodge住宿设施的所有癌症患者及其护理人员。所有感兴趣的参与者都被包括在内,因为没有为研究设定资格标准。该课程的可用性通过对讲机、显示器和口碑进行了宣传。参与者接受了五种不同的呼吸练习,在一次训练完成后,进行自我报告的质量改善问卷调查,评估社会人口统计学/临床因素、对训练的期望以及对训练的满意度。结果在9个月的数据收集期内,52名参与者提供了反馈,其中患者和护理人员的人数几乎相等。参与者对干预接受、症状管理、对课程的满意度以及未来练习需求的认知表明,瑜伽呼吸课程有助于改善癌症体验的一些关键症状,如压力。结论研究结果表明,瑜伽呼吸对患者和护理人员来说是可以接受的,可能有助于减轻癌症治疗的一些副作用,并且在治疗期间在住宿设施进行干预是可行的。目前,瑜伽呼吸课程由研究团队培训的Hope Lodge志愿者每周进行一次。
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引用次数: 1
Qigong for the mental health of teachers – A prospective randomized controlled trial 气功对教师心理健康的影响——一项前瞻性随机对照试验
Pub Date : 2023-07-01 DOI: 10.1016/j.bbii.2023.100018
Mário Gonçalves , Renato Oliveira , Jorge Magalhães Rodrigues , Cristina Ventura , Jorge Machado , Henry Johannes Greten

The development of mental health care has changed greatly from ancient civilisations to the present day. Today, teachers' mental health and well-being are in a precarious state, and when lack of training is added, it becomes clear how difficult it is for teachers to provide adequate support to students. This can be exacerbated by specific contexts and cultures in which teachers may feel uncomfortable seeking help. The lack of support for teachers can lead to the development of long-term mental health problems, with negative personal, professional, and social consequences. Because teacher well-being directly impacts student well-being, achievement, and success, it is crucial to promote teachers' mental health. Qigong may be considered a patient-guided psychophysiological feedback technique that enables subjects to learn and control bodily functions and processes. The present study aimed to investigate the potential impact of Qigong on teachers' anxiety, depression, and stress levels, and to explore the feasibility of integrating it into the school context. Eighty-four participants were recruited and randomly divided into two groups. The experimental group received the Qigong intervention and the control group received a placebo intervention, both for 4 weeks. The outcomes were anxiety, depression and stress levels and were assessed using various scales and complementary physiological parameters. Regarding anxiety, the experimental group showed significant improvements in all outcome measures, while the placebo group showed similar scores in the pre- and post-measurements. The post-intervention results even showed a significant difference between the two groups in terms of state anxiety. In terms of depression and stress, the results suggest that Qigong can significantly improve symptoms. The placebo group showed no significant changes. However, no significant differences were found between the groups in the final assessment. The results of this study suggest that Qigong can help improve teachers' mental health and can be implemented in schools.

从古代文明到今天,精神卫生保健的发展发生了巨大变化。如今,教师的心理健康和福祉处于不稳定状态,再加上缺乏培训,教师很难为学生提供足够的支持。在特定的环境和文化中,教师可能会对寻求帮助感到不舒服,这可能会加剧这种情况。缺乏对教师的支持可能导致长期心理健康问题的发展,并带来负面的个人、职业和社会后果。由于教师的幸福感直接影响学生的幸福感、成就和成功,因此促进教师的心理健康至关重要。气功可以被认为是一种患者指导的心理生理反馈技术,使受试者能够学习和控制身体功能和过程。本研究旨在调查气功对教师焦虑、抑郁和压力水平的潜在影响,并探索将其融入学校环境的可行性。84名参与者被招募并随机分为两组。实验组接受气功干预,对照组接受安慰剂干预,均持续4周。结果是焦虑、抑郁和压力水平,并使用各种量表和补充生理参数进行评估。关于焦虑,实验组在所有结果测量中都有显著改善,而安慰剂组在前后测量中得分相似。干预后的结果甚至显示,两组在状态焦虑方面存在显著差异。在抑郁和压力方面,研究结果表明气功可以显著改善症状。安慰剂组无明显变化。然而,在最终评估中,两组之间没有发现显著差异。研究结果表明,气功有助于改善教师的心理健康,可以在学校实施。
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引用次数: 0
Antiparkinsonian effects of Indian spice Amomum subulatum fruit extract by modulating the behavioural, inflammatory markers, antioxidant, and histopathology parameters in rats 印度香料砂木果实提取物通过调节大鼠行为、炎症标志物、抗氧化和组织病理学参数的抗帕金森作用
Pub Date : 2023-07-01 DOI: 10.1016/j.bbii.2023.100015
Alisha Gazmer, Manodeep Chakraborty, Devid Chutia, Ananya Bhattacharjee, Nihar Ranjan Bhuyan

Parkinson's disease (PD) is a complex neurodegenerative disorder associated with the loss of dopaminergic neurons in the substantia nigra followed by dopamine depletion in the striatum. PD usually affects people over 50; when those under 50 are involved, it is generally referred to as early-onset PD. The present study aimed to understand and explain the role of the typical Indian spice, greater cardamom, against parkinsonism and related complications. The methanolic extract of Amomum subulatum has flavonoids as the major phytoconstituent and may be a beneficial adjuvant in treating PD. Amomum subulatum fruit extract (ASFE) was given as treatment to the rats at 100 mg/kg and 200 mg/kg. Symptoms of Parkinson’s disease, such as tremors, muscular rigidity, catalepsy, locomotor activity, and grip strength, were examined by several behavioural tests. Treatment with ASFE showed a significant decrease in all the symptoms of PD. Enzyme assays revealed a reduction in the levels of antioxidant enzymes SOD, Catalase, and GSH after administering reserpine and increased levels after treating ASFE. ASFE causes dopaminergic neuron regeneration after reserpine induces injury, thus increasing dopamine levels and restoring cellular damage. The inflammatory biomarkers revealed decreased proinflammatory cytokines such as TNF-α and IL-6. In contrast, increase in the level of IL-10, which is an anti-inflammatory cytokine. The histopath studies showed reduced cell damage occurring in PD after the treatment with ASFE. The present investigation highlights the role of greater cardamom from the Indian kitchen to ethnopharmacology in progressive neurological degeneration.

帕金森病(PD)是一种复杂的神经退行性疾病,与黑质多巴胺能神经元的丧失以及纹状体多巴胺的耗竭有关。帕金森病通常影响50岁以上的人;当50岁以下的人参与时,通常被称为早发性帕金森病。本研究旨在了解和解释典型的印度香料大豆蔻对帕金森病和相关并发症的作用。砂仁甲醇提取物以黄酮类化合物为主要植物成分,可能是治疗帕金森病的有益佐剂。帕金森氏症的症状,如震颤、肌肉强直、催化、运动活动和握力,通过几项行为测试进行了检查。ASFE治疗显示PD的所有症状都显著减轻。酶测定显示,服用利血平后,抗氧化酶SOD、过氧化氢酶和GSH水平降低,治疗ASFE后水平升高。ASFE在利血平诱导损伤后引起多巴胺能神经元再生,从而提高多巴胺水平并恢复细胞损伤。炎症生物标志物显示促炎细胞因子如TNF-α和IL-6减少。相反,IL-10水平升高,IL-10是一种抗炎细胞因子。组织病理学研究表明,在用ASFE治疗后,PD中发生的细胞损伤减少。目前的研究强调了从印度厨房到民族药理学的大豆蔻在进行性神经退行性变中的作用。
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引用次数: 0
Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy 体育锻炼对BDNF和认知功能影响的实验和临床证据:从分子基础到治疗的综合综述
Pub Date : 2023-07-01 DOI: 10.1016/j.bbii.2023.100017
Masoomeh Dadkhah , Maryam Saadat , Amir Mohammad Ghorbanpour , Nasrollah Moradikor

Understanding how physical exercise (PE) can influence brain function, especially cognition, through the modulatory effects of brain-derived neurotrophic factor (BDNF) has been extensively studied over the past few decades. Several studies have reported a relationship between PE and brain function in animals and humans. Recently, evidence has shown that exercise positively affects brain structure and brain functions such as learning and memory. Furthermore, the beneficial effect of voluntary physical activity on cognitive performance through modulating neurotrophic factors has been reported. This review aims to shed light on our current knowledge of how PE affects brain structure and the molecular events in brain areas associated with functions such as learning and memory processes. We provide evidence that exercise can improve common therapies against cognitive deficits through developing BDNF level in brain. We also highlight the critical role of exercise as a modulator of the relationship between cognition and BDNF alternations in neuropsychiatric disorders, based on animal and human research. Finally, the effects of physical activity on BDNF based on experimental and clinical studies will be addressed.

在过去的几十年里,人们对体育锻炼如何通过脑源性神经营养因子(BDNF)的调节作用影响大脑功能,尤其是认知进行了广泛的研究。几项研究报告了PE与动物和人类大脑功能之间的关系。最近,有证据表明,运动对大脑结构和学习记忆等大脑功能有积极影响。此外,还报道了自愿体育活动通过调节神经营养因子对认知能力的有益影响。这篇综述旨在阐明我们目前对PE如何影响大脑结构以及与学习和记忆过程等功能相关的大脑区域的分子事件的了解。我们提供的证据表明,运动可以通过提高大脑中BDNF水平来改善针对认知缺陷的常见疗法。基于动物和人类的研究,我们还强调了运动在神经精神疾病中作为认知和BDNF变化之间关系的调节剂的关键作用。最后,基于实验和临床研究,将讨论体育活动对BDNF的影响。
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引用次数: 0
Management of palmoplantar psoriasis and its comorbidities using yoga and naturopathic lifestyle interventions: A case report 使用瑜伽和自然疗法生活方式干预掌跖牛皮癣及其合并症的管理:一个病例报告
Pub Date : 2023-04-01 DOI: 10.1016/j.bbii.2023.100011
Gulab Rai Tewani , Sucheta Kriplani , Hemanshu Sharma , Pradeep MK Nair

Palmoplantar psoriasis is an autoimmune disorder that contributes to significant functional disability. Apart from the chronic inflammatory reactions in the skin, psoriasis patients are more likely to develop chronic systemic disorders, which impose significant physical, mental, and economic burdens. This warrants a holistic, patient-centered approach that can address the prevailing multimorbidity in psoriasis patients. Yoga and Naturopathy-based Lifestyle Interventions (YNBL) are known for their whole-person approach and are reported to be beneficial in the management of autoimmune disorders. We report a case of a 63-year-old male treated with YNBL for palmoplantar psoriasis along with diabetes mellitus, coronary artery disease, low back pain, and insomnia. The patient underwent YNBL in an inpatient setting for 10 days each with a gap of 7 months, along with follow-up advises. The prognosis was measured through the Psoriasis Area and Severity Index, along with other biochemical markers like fasting blood sugar, random blood sugar, vitamins D and B12, and subjective visual analog scores for vitality and other symptoms. He achieved complete remission of psoriasis by the end of 8 months, and the results were sustained even during the follow-up. The results are encouraging for using the YNBL protocol in the management of palmoplantar psoriasis; however, these findings need to be validated using clinical trial designs.

掌跖银屑病是一种自身免疫性疾病,可导致严重的功能残疾。除了皮肤中的慢性炎症反应外,银屑病患者更有可能发展为慢性系统性疾病,这会带来巨大的身体、精神和经济负担。这就保证了一种以患者为中心的整体方法,可以解决银屑病患者普遍存在的多发性疾病。基于瑜伽和自然疗法的生活方式干预(YNBL)以其全人方法而闻名,据报道对自身免疫性疾病的治疗有益。我们报告了一例63岁男性用YNBL治疗掌跖银屑病并伴有糖尿病、冠状动脉疾病、腰痛和失眠的病例。患者在住院环境中接受了为期10天的YNBL,间隔7个月,并提供了随访建议。通过银屑病面积和严重程度指数,以及其他生化指标,如空腹血糖、随机血糖、维生素D和B12,以及活力和其他症状的主观视觉模拟评分来衡量预后。他在8个月结束时实现了银屑病的完全缓解,即使在随访期间,结果也保持不变。该结果对于使用YNBL方案治疗掌跖银屑病是令人鼓舞的;然而,这些发现需要通过临床试验设计来验证。
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引用次数: 0
Efficacy of Nardostachys jatamansi (D.Don) DC in post stroke depression: A randomized, double blind, controlled trial Nardostachys jatamansi (D.Don) DC治疗脑卒中后抑郁的疗效:一项随机、双盲、对照试验
Pub Date : 2023-04-01 DOI: 10.1016/j.bbii.2023.100012
Muzafar Din Ahmad Bhat, Husain Ahmad

Background

Post-stroke Depression (PSD) is a frequent neuropsychiatric manifestation of high clinical importance as it adversely affects recovery and quality of life, interferes with rehabilitation, and is a significant source of burden to caregivers. Prevalence rates of PSD range from 25% to 79%. The reason for treatment failure in patients of PSD includes the timing of intervention or the side effects of medications. Nardostachys jatamansi (D.Don) DC is commonly used in traditional medicine systems for neuropsychiatric and psychosomatic disorders with the least or no side effects. However, its clinical efficacy in PSD remains unraveled. The study aimed to evaluate the efficacy of Nardostachys jatamansi in PSD.

Methods

Present study was a double-blind randomized placebo-controlled trial with 20 patients in each test and control group. Participants were randomly allocated to receive Nardostachys jatamansi 3gms (powder) in the test group or placebo in the control group for six weeks. Participants were asked to follow up fortnightly for the assessment of subjective parameters. Objective parameters (Hamilton Depression Rating Scale (HDRS17) score and 36-Item Short Form Survey (SF-36) were assessed at baseline and end of the trial.

Results

After 6 weeks of treatment, there was a statistically significant reduction in HDRS17 score and SF-36 (p < 0.001), whereas there was no significant difference in the control group (P = 0.108, and 0.29 respectively). Comparison between baseline and post-treatment scores in the test group showed a positive reduction in all subjective parameters however, in the control group there was no statistically significant change. The intergroup analysis revealed that the reduction in HDRS17 score and improvement in SF-36 score was statistically significant in the test group than the control group (P < 0.001).

Conclusion

The study revealed that the test drug is effective in the management of PSD. There was no adverse effect observed during the trial.

背景脑卒中后抑郁(PSD)是一种常见的具有高度临床重要性的神经精神表现,因为它对康复和生活质量产生不利影响,干扰康复,并且是护理人员负担的重要来源。PSD的患病率在25%到79%之间。PSD患者治疗失败的原因包括干预时间或药物副作用。Nardostachys jatamansi(D.Don)DC通常用于传统医学系统中治疗神经精神和心身疾病,副作用最小或没有副作用。然而,它在PSD中的临床疗效仍不清楚。本研究旨在评估日本Nardostachys jatamansi治疗帕金森病的疗效。方法本研究是一项双盲随机安慰剂对照试验,每组20名患者。参与者被随机分配接受试验组的Nardostachys jatamansi 3g(粉末)或对照组的安慰剂,为期六周。参与者被要求每两周随访一次,以评估主观参数。在基线和试验结束时评估客观参数(汉密尔顿抑郁量表(HDRS17)评分和36项简式调查(SF-36)。结果治疗6周后,HDRS17评分和SF-36评分均有统计学意义的降低(p<0.001),而对照组无显著差异(p分别为0.108和0.29)。试验组的基线和治疗后评分之间的比较显示,所有主观参数都呈阳性降低,但对照组没有统计学上的显著变化。组间分析显示,试验组HDRS17评分的降低和SF-36评分的改善与对照组相比具有统计学意义(P<;0.001)。试验期间未观察到任何不良反应。
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引用次数: 1
The effection pain and anxiety of a breathing exercise applied following laparoscopic cholecystectomy: A randomized controlled study 腹腔镜胆囊切除术后呼吸练习对疼痛和焦虑的影响:一项随机对照研究
Pub Date : 2023-04-01 DOI: 10.1016/j.bbii.2023.100008
Ozge Karagoz , Aylin Aydin Sayilan

Background

Several methods are employed for overcoming pain and anxiety that are frequently experienced in the postoperative period. This study was planned to determine the effect of a breathing exercise on patient pain and anxiety after laparoscopic cholecystectomy.

Materials and methods

The sample determined using power analysis in this randomized, controlled, semi-experimental research performed in two hospitals in the west of Turkey between January and November 2019 consisted of 74 individuals (37 experimental and 37 controls). An information form involving descriptive characteristics, a visual analog scale (VAS), and the State-Trait Anxiety Inventory (STAI I/II) were used for data collection. Descriptive statistical methods and parametric tests were employed in the data analysis.

Results

Pain and state and trait anxiety scores were significantly lower in the group receiving breathing exercises compared to the no exercise group (p < 0.05). No significant relationship was determined between pain and state anxiety levels (p > 0.05).

Conclusion

The breathing exercise applied following surgical intervention in this study exerted a positive effect on pain and anxiety. This finding suggested that nurses should apply the exercise in a standard and effective manner among their independent duties.

背景采用几种方法来克服术后经常出现的疼痛和焦虑。本研究旨在确定呼吸练习对腹腔镜胆囊切除术后患者疼痛和焦虑的影响。材料和方法2019年1月至11月,在土耳其西部的两家医院进行的这项随机、对照、半实验研究中,使用幂分析确定的样本由74人组成(37名实验和37名对照)。数据收集采用描述性特征信息表、视觉模拟量表(VAS)和状态-特质焦虑量表(STAI I/II)。数据分析采用描述性统计方法和参数检验。结果与不运动组相比,接受呼吸训练组的疼痛、状态和特质焦虑评分显著降低(p<0.05)。疼痛和状态焦虑水平之间没有显著关系(p>0.05)。这一发现表明,护士应在其独立职责中以标准和有效的方式进行锻炼。
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引用次数: 1
Understanding the dynamics of inflammatory mediators in response to mind-body movement therapies (MBMTs): A systematic review and meta-analysis of studies in healthy subjects 了解炎症介质对心身运动疗法(MBMTs)反应的动力学:对健康受试者研究的系统回顾和荟萃分析
Pub Date : 2023-04-01 DOI: 10.1016/j.bbii.2023.100006
Dennis Muñoz-Vergara , Wren Burton , Paul Bain , Pamela M. Rist , Sat Bir S. Khalsa , Kristin L. Schreiber , Peter M. Wayne , Gloria Y. Yeh

Background

Modulation of inflammation has been proposed as a potentially important aspect of mind-body movement therapies (MBMTs). Research from the sports medicine has delineated the inflammatory cascade after conventional exercise; however, relatively less is known regarding modulation of inflammation after MBMTs.

Objective

To synthesize the available literature investigating the short- and long-term impact of MBMT interventions on systemic inflammatory mediators in healthy individuals.

Methods

We conducted a systematic review and meta-analysis of inflammatory mediators according to Preferred Reporting Items for Systematic Review and Meta-Analyses Guidelines. We sought RCTs in healthy individuals comparing MBMTs with passive or active controls that measured systemic inflammatory markers. We used the Cochrane risk-of-bias tool for randomized trials. Hedges’s g and 95% CIs were computed across studies.

Results

Of 3122 studies identified, 23 were eligible for synthesis. Most common MBMTs studied were yoga(n = 11), qigong(n = 4), tai chi(n = 3), MBSR(n = 3), and dance therapy(n = 2). Frequency of practice (most commonly 3 times/week), intervention duration (3 short-term, single session and 20 long-term with repeated sessions for>1 week), and session length (most commonly 30–60 min) showed high heterogeneity between studies. Pro- and anti-inflammatory proteins were most commonly measured (n = 20 studies), followed by immune cells (n = 5), lipid mediators (n = 4), and humoral and complement factors (n = 2). Most showed no change or decrease in inflammatory mediators, with fewer showing increased levels. Meta-analyses suggested a significant decrease in systemic levels of CRP (Hedges’s g = −0.351; CI = −0.580, −0.123) and TNF-α (Hedges’s g = −0.366; CI = −0.669, −0.064), and a trend toward decreased IL-6 after long-term MBMTs (Hedges’s g = −0.394; CI = −0.819, 0.030).

Conclusion

While findings suggest inflammatory proteins, including CRP, TNF-α, and IL-6 decrease with long-term MBMTs similar to conventional exercise, the overall trajectory of change in inflammatory mediators after MBMT may be more nuanced. Future carefully-controlled studies including precise intervention parameters evaluating pre-post changes will be required to understand both short- and long-term effects of MBMTs, as well as gauge how these changes relate to symptom relief when employed in patients with chronic conditions.PROSPERO ID CRD42022315399

背景炎症的调节已被认为是身心运动疗法(MBMT)的一个潜在的重要方面。运动医学的研究描绘了常规运动后的炎症级联反应;然而,关于MBMT后炎症调节的研究相对较少。目的综合现有文献,研究MBMT干预对健康个体全身炎症介质的短期和长期影响。方法根据系统评价首选报告项目和荟萃分析指南,对炎症介质进行系统评价和荟萃分析。我们寻求在健康个体中进行随机对照试验,将MBMT与测量全身炎症标志物的被动或主动对照进行比较。我们在随机试验中使用了Cochrane偏倚风险工具。Hedges的g和95%置信区间在各研究中进行了计算。结果在已鉴定的3122项研究中,23项符合合成条件。所研究的最常见的MBMT是瑜伽(n=11)、气功(n=4)、太极(n=3)、MBSR(n=3)和舞蹈疗法(n=2)。练习频率(最常见的是每周3次)、干预持续时间(3次短期、单次和20次长期,重复时间大于1周)和疗程长度(最常见为30-60分钟)显示出研究之间的高度异质性。最常见的是前和抗炎蛋白(n=20项研究),其次是免疫细胞(n=5)、脂质介质(n=4)以及体液和补体因子(n=2)。大多数炎症介质没有变化或减少,很少有炎症介质水平升高。荟萃分析表明,长期MBMT后,全身CRP水平显著下降(Hedges g=-0.351;CI=-0.580,-0.123)和TNF-,和IL-6随着类似于传统运动的长期MBMT而降低,MBMT后炎症介质的总体变化轨迹可能更为微妙。未来需要进行仔细控制的研究,包括评估前后变化的精确干预参数,以了解MBMT的短期和长期影响,并衡量这些变化与慢性病患者症状缓解的关系。普罗旺索ID CRD42022315399
{"title":"Understanding the dynamics of inflammatory mediators in response to mind-body movement therapies (MBMTs): A systematic review and meta-analysis of studies in healthy subjects","authors":"Dennis Muñoz-Vergara ,&nbsp;Wren Burton ,&nbsp;Paul Bain ,&nbsp;Pamela M. Rist ,&nbsp;Sat Bir S. Khalsa ,&nbsp;Kristin L. Schreiber ,&nbsp;Peter M. Wayne ,&nbsp;Gloria Y. Yeh","doi":"10.1016/j.bbii.2023.100006","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100006","url":null,"abstract":"<div><h3>Background</h3><p>Modulation of inflammation has been proposed as a potentially important aspect of mind-body movement therapies (MBMTs). Research from the sports medicine has delineated the inflammatory cascade after conventional exercise; however, relatively less is known regarding modulation of inflammation after MBMTs.</p></div><div><h3>Objective</h3><p>To synthesize the available literature investigating the short- and long-term impact of MBMT interventions on systemic inflammatory mediators in healthy individuals.</p></div><div><h3>Methods</h3><p>We conducted a systematic review and meta-analysis of inflammatory mediators according to Preferred Reporting Items for Systematic Review and Meta-Analyses Guidelines. We sought RCTs in healthy individuals comparing MBMTs with passive or active controls that measured systemic inflammatory markers. We used the Cochrane risk-of-bias tool for randomized trials. Hedges’s g and 95% CIs were computed across studies.</p></div><div><h3>Results</h3><p>Of 3122 studies identified, 23 were eligible for synthesis. Most common MBMTs studied were yoga(n = 11), qigong(n = 4), tai chi(n = 3), MBSR(n = 3), and dance therapy(n = 2). Frequency of practice (most commonly 3 times/week), intervention duration (3 short-term, single session and 20 long-term with repeated sessions for&gt;1 week), and session length (most commonly 30–60 min) showed high heterogeneity between studies. Pro- and anti-inflammatory proteins were most commonly measured (n = 20 studies), followed by immune cells (n = 5), lipid mediators (n = 4), and humoral and complement factors (n = 2). Most showed no change or decrease in inflammatory mediators, with fewer showing increased levels. Meta-analyses suggested a significant decrease in systemic levels of CRP (Hedges’s g = −0.351; CI = −0.580, −0.123) and TNF-α (Hedges’s g = −0.366; CI = −0.669, −0.064), and a trend toward decreased IL-6 after long-term MBMTs (Hedges’s g = −0.394; CI = −0.819, 0.030).</p></div><div><h3>Conclusion</h3><p>While findings suggest inflammatory proteins, including CRP, TNF-α, and IL-6 decrease with long-term MBMTs similar to conventional exercise, the overall trajectory of change in inflammatory mediators after MBMT may be more nuanced. Future carefully-controlled studies including precise intervention parameters evaluating pre-post changes will be required to understand both short- and long-term effects of MBMTs, as well as gauge how these changes relate to symptom relief when employed in patients with chronic conditions.PROSPERO ID CRD42022315399</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Adansonia digitata L. fruit shell prevents aluminum-induced cognitive impairment and depression in mice Adansonia digitata L.果壳对铝诱导的小鼠认知障碍和抑郁的预防作用
Pub Date : 2023-04-01 DOI: 10.1016/j.bbii.2023.100014
Haruna Ahmed Usman , Samaila Musa Chiroma , Joseph Vandi Zirahei , Nathan Isaac Dibal

Purpose

Aluminum exposure can lead to free radicals production and increased susceptibility to lipids peroxidation in the central nervous system. The was aimed at evaluating the role of acetone extract of A. digitata shell acetone extract (ASAE) on oxidative stress, acetylcholinesterase (AChE) level, and hippocampal histology of aluminum chloride (AlCl3)-treated rats.

Methods

Twenty-five rats were allotted into five groups (n = 5). The groups received distilled water, 250 mg/kg aluminum chloride, 250 mg/kg ASAE plus AlCl3, 500 mg/kg ASAE plus AlCl3, and 200 mg/kg Vitamin C plus AlCl3 respectively once daily for sixty days. Modified elevated plus maze (mEPM) and force swim test was conducted after 24 h. One half of the rat brain was homogenized and used to evaluate AChE level and oxidative stress biomarkers while the other half was processed for light microscopy.

Results

Pre-treatment with ASAE was shown to significantly decrease (p < .05) the first transfer latency of mEPM and immobility time of the force swim test relative to the AlCl3-treated rats. The brain AChE level was significantly increased (p < .05) in rats treated with AlCl3 relative to the control. ASAE was found to regulate the AChE level. ASAE was found to significantly elevate (p < .05) superoxide dismutase and catalase activity relative to the control and AlCl3-treated rats.

Conclusions

The findings of the current study revealed that ASAE could prevent AlCl3-induced cognitive impairment and depression. It also regulated brain AChE levels and enhanced antioxidant activity. These suggest that ASAE could serve as a natural product for preventing oxidative stress-related diseases.

目的铝暴露可导致中枢神经系统中自由基的产生和脂质过氧化的易感性增加。目的评价A.digita壳丙酮提取物(ASAE)对氯化铝(AlCl3)处理大鼠氧化应激、乙酰胆碱酯酶(AChE)水平和海马组织学的影响。方法将25只大鼠随机分为5组(n=5)。各组分别接受蒸馏水、250 mg/kg氯化铝、250 mg/kg ASAE加AlCl3、500 mg/kg ASAE加AlCl3和200 mg/kg维生素C加AlCl3.每天一次,持续60天。24小时后进行改良的高架+迷宫(mPEM)和力泳试验。将大鼠大脑的一半匀浆并用于评估AChE水平和氧化应激生物标志物,而另一半进行光学显微镜处理。结果与AlCl3处理的大鼠相比,ASAE预处理显著降低(p<0.05)mPEM的第一次转移潜伏期和力泳试验的不动时间。与对照相比,用AlCl3处理的大鼠的脑AChE水平显著增加(p<0.05)。ASAE可调节乙酰胆碱酯酶水平。发现ASAE相对于对照和AlCl3处理的大鼠显著提高(p<0.05)超氧化物歧化酶和过氧化氢酶活性。结论ASAE可预防AlCl3引起的认知障碍和抑郁。它还调节大脑AChE水平并增强抗氧化活性。这表明ASAE可以作为一种天然产物预防氧化应激相关疾病。
{"title":"Adansonia digitata L. fruit shell prevents aluminum-induced cognitive impairment and depression in mice","authors":"Haruna Ahmed Usman ,&nbsp;Samaila Musa Chiroma ,&nbsp;Joseph Vandi Zirahei ,&nbsp;Nathan Isaac Dibal","doi":"10.1016/j.bbii.2023.100014","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100014","url":null,"abstract":"<div><h3>Purpose</h3><p>Aluminum exposure can lead to free radicals production and increased susceptibility to lipids peroxidation in the central nervous system. The was aimed at evaluating the role of acetone extract of <em>A. digitata</em> shell acetone extract (ASAE) on oxidative stress, acetylcholinesterase (AChE) level, and hippocampal histology of aluminum chloride (AlCl3)-treated rats.</p></div><div><h3>Methods</h3><p>Twenty-five rats were allotted into five groups (n = 5). The groups received distilled water, 250 mg/kg aluminum chloride, 250 mg/kg ASAE plus AlCl3, 500 mg/kg ASAE plus AlCl3, and 200 mg/kg Vitamin C plus AlCl3 respectively once daily for sixty days. Modified elevated plus maze (mEPM) and force swim test was conducted after 24 h. One half of the rat brain was homogenized and used to evaluate AChE level and oxidative stress biomarkers while the other half was processed for light microscopy.</p></div><div><h3>Results</h3><p>Pre-treatment with ASAE was shown to significantly decrease (p &lt; .05) the first transfer latency of mEPM and immobility time of the force swim test relative to the AlCl3-treated rats. The brain AChE level was significantly increased (p &lt; .05) in rats treated with AlCl3 relative to the control. ASAE was found to regulate the AChE level. ASAE was found to significantly elevate (p &lt; .05) superoxide dismutase and catalase activity relative to the control and AlCl3-treated rats.</p></div><div><h3>Conclusions</h3><p>The findings of the current study revealed that ASAE could prevent AlCl3-induced cognitive impairment and depression. It also regulated brain AChE levels and enhanced antioxidant activity. These suggest that ASAE could serve as a natural product for preventing oxidative stress-related diseases.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Brain Behavior and Immunity Integrative
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