Pub Date : 2025-01-01DOI: 10.1016/j.bbii.2025.100108
Kaixuan Xu , Dongli Song , Hui Li , Yushan Lu , Zhongliang Zhu
Prenatal stress (PS) represents a critical environmental factor that causes developmental disruptions in offspring, characterized by multisystemic vulnerabilities across neuropsychiatric, cardiovascular, metabolic, and immunological domains. Through intricate embryonic reprogramming mechanisms, PS alters brain developmental trajectories and physiological regulatory networks, resulting in increased long-term risks for neurodevelopmental disorders, particularly depressive-like behavior. PS causes dysregulation in multiple physiological processes, including hypothalamic-pituitary-adrenal (HPA) axis activation, epigenetic modifications, neurotransmitter systems, brain-derived neurotrophic factor (BDNF), gut microbiota, and neuroimmune responses. Additionally, genetic factors, sex specificity, and critical developmental windows further complicate the PS-mediated onset of depressive-like behavior. Here, we review clinical and animal studies and analyze how the multiple mechanisms form complex regulatory networks during intrauterine development, leading to long-lasting psychopathological effects in offspring.
{"title":"Advance in the mechanisms underlying prenatal stress-induced depressive-like behavior in offspring","authors":"Kaixuan Xu , Dongli Song , Hui Li , Yushan Lu , Zhongliang Zhu","doi":"10.1016/j.bbii.2025.100108","DOIUrl":"10.1016/j.bbii.2025.100108","url":null,"abstract":"<div><div>Prenatal stress (PS) represents a critical environmental factor that causes developmental disruptions in offspring, characterized by multisystemic vulnerabilities across neuropsychiatric, cardiovascular, metabolic, and immunological domains. Through intricate embryonic reprogramming mechanisms, PS alters brain developmental trajectories and physiological regulatory networks, resulting in increased long-term risks for neurodevelopmental disorders, particularly depressive-like behavior. PS causes dysregulation in multiple physiological processes, including hypothalamic-pituitary-adrenal (HPA) axis activation, epigenetic modifications, neurotransmitter systems, brain-derived neurotrophic factor (BDNF), gut microbiota, and neuroimmune responses. Additionally, genetic factors, sex specificity, and critical developmental windows further complicate the PS-mediated onset of depressive-like behavior. Here, we review clinical and animal studies and analyze how the multiple mechanisms form complex regulatory networks during intrauterine development, leading to long-lasting psychopathological effects in offspring.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.bbii.2024.100100
Jiyi Xu , Yi Zhang , Lei Li , Xiaodong Zhao , Feilong Huang , Jing Du
Major depressive disorder (MDD) is a common disease affecting 300 million people worldwide. Current drugs are ineffective for at least 30 % of the patients. Novel and personalized medication is needed urgently. Cumulative studies suggest that the neuroinflammation of the glial cells, particularly NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and subsequent regulation of synaptic functions may be the key for the pathophysiology and treatment of MDD. In this review, we delve to compare the modern mechanism of MDD treatment with the theories of differential symptoms for personalized treatment of the ancient decoctions from traditional Chinese Medicine (TCM). Interestingly, the mechanisms of MDD treatment from Western and TCM theories overlap to a nexus on regulating neuro-immune signaling pathways, including NLRP 3 inflammasome, cytokine expressions and synaptic functions. In this review, we have summarized 8 differential syndromes and 10 decoctions for the TCM treatment of MDD in modulation of immune system and synaptic functions. The neuroimmune modulation of the 10 decoctions for the treatment MDD from TCM are amazingly similar towards the anti-inflammatory effects and enhancing synaptic functions. The comparison of theories and therapies from Western medicine and TCM may contribute to the development of more effective and safer medication for MDD.
{"title":"An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD","authors":"Jiyi Xu , Yi Zhang , Lei Li , Xiaodong Zhao , Feilong Huang , Jing Du","doi":"10.1016/j.bbii.2024.100100","DOIUrl":"10.1016/j.bbii.2024.100100","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a common disease affecting 300 million people worldwide. Current drugs are ineffective for at least 30 % of the patients. Novel and personalized medication is needed urgently. Cumulative studies suggest that the neuroinflammation of the glial cells, particularly NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and subsequent regulation of synaptic functions may be the key for the pathophysiology and treatment of MDD. In this review, we delve to compare the modern mechanism of MDD treatment with the theories of differential symptoms for personalized treatment of the ancient decoctions from traditional Chinese Medicine (TCM). Interestingly, the mechanisms of MDD treatment from Western and TCM theories overlap to a nexus on regulating neuro-immune signaling pathways, including NLRP 3 inflammasome, cytokine expressions and synaptic functions. In this review, we have summarized 8 differential syndromes and 10 decoctions for the TCM treatment of MDD in modulation of immune system and synaptic functions. The neuroimmune modulation of the 10 decoctions for the treatment MDD from TCM are amazingly similar towards the anti-inflammatory effects and enhancing synaptic functions. The comparison of theories and therapies from Western medicine and TCM may contribute to the development of more effective and safer medication for MDD.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.bbii.2024.100102
Reshu , Surendra Kumar , Ashutosh Rathi
Background
In today’s educational milieu, rising mental and physical health issues among adolescents pose an imperative concern for schools. While yoga has shown growing therapeutic benefits, research addressing emerging concerns—such as internet addiction, and associated cognitive and sleep disorders—remains underexplored, especially in the post-COVID-19 era and within school curricula.
Objective
This pilot, randomized-controlled trial with high school students aimed to validate a concise, 25-minute yogic intervention tailored for adolescent well-being in academic settings.
Measures
Quantitative assessment tools included the Academic Anxiety Scale for Children, Concentration Questionnaire, Internet Addiction Test, Insomnia Severity Index, and General Health Questionnaire.
Results
Over a three-month period, students who practiced yoga reported marked improvements in internet resilience, academic anxiety, concentration, and insomnia symptoms (all p < 0.0001). Additionally, they showed significant reductions in general health complaints (e.g., headaches, stomach aches), with p-values ranging from p < 0.05 to p < 0.001. Conversely, the control group showed no significant changes, except for a worsening of internet addiction.
Conclusion
These findings suggest that even brief, consistent yoga practice can yield substantial benefits, advocating for its integration into school curricula to promote a healthier, more resilient generation of learners.
{"title":"School-based yoga intervention for internet resilience and holistic well-being of adolescents","authors":"Reshu , Surendra Kumar , Ashutosh Rathi","doi":"10.1016/j.bbii.2024.100102","DOIUrl":"10.1016/j.bbii.2024.100102","url":null,"abstract":"<div><h3>Background</h3><div>In today’s educational milieu, rising mental and physical health issues among adolescents pose an imperative concern for schools. While yoga has shown growing therapeutic benefits, research addressing emerging concerns—such as internet addiction, and associated cognitive and sleep disorders—remains underexplored, especially in the post-COVID-19 era and within school curricula.</div></div><div><h3>Objective</h3><div>This pilot, randomized-controlled trial with high school students aimed to validate a concise, 25-minute yogic intervention tailored for adolescent well-being in academic settings.</div></div><div><h3>Measures</h3><div>Quantitative assessment tools included the Academic Anxiety Scale for Children, Concentration Questionnaire, Internet Addiction Test, Insomnia Severity Index, and General Health Questionnaire.</div></div><div><h3>Results</h3><div>Over a three-month period, students who practiced yoga reported marked improvements in internet resilience, academic anxiety, concentration, and insomnia symptoms (all p < 0.0001). Additionally, they showed significant reductions in general health complaints (e.g., headaches, stomach aches), with p-values ranging from p < 0.05 to p < 0.001. Conversely, the control group showed no significant changes, except for a worsening of internet addiction.</div></div><div><h3>Conclusion</h3><div>These findings suggest that even brief, consistent yoga practice can yield substantial benefits, advocating for its integration into school curricula to promote a healthier, more resilient generation of learners.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.bbii.2025.100105
Jianmei Yang , Yining Gu , Guang Yang , Waimao Gao , Lei Chen , Yiyun Bao , Kai Meng , Lingyan Zhu , Tengteng Zhou , Xingyu Wang , Ying Xu
Neuroinflammation is supposed to be a crucial factor in the pathophysiology of migraine, which is caused by intracranial vasodilation and the release of vasoactive peptides. Fu-Fang-Li-Shao Pill (FFLSP), a prescription composed of Tribulus terrestris, Radix Paeoniae Alba, Radix Puerariae, Radix Salviae Miltiorrhizae, White Chrysanthemum, Uncariae Ramulus Cum Uncis, Concha Margaritifera, Fructus Viticis, Angelica Dahurica and Mentha Haplocalyx Briq, is an effective proved recipe for migraine patients which is developed by Shanghai Xuhui District Central Hospital. However, the pharmacological mechanisms of FFLSP in relieving migraine are not well understood. This study aims to assess the therapeutic effect of FFLSP on chronic migraine and to elucidate the underlying mechanisms. In our study, through the repeated subcutaneous injection of nitroglycerin (NTG), an animal model of chronic migraine was established which showed migraine-like symptoms such as head pain, ear redness and irritability. Here, NTG-induced chronic migraine rats were used to evaluate the inhibitory effect of FFLSP on neuroinflammation by conducting behavioral tests and molecular biology analyses. We observed that FFLSP possesses an excellent ability to relieve chronic migraine. FFLSP treatment was able to inhibit vasodilation by decreasing c-Fos and CGRP expressions in dura mater and trigeminal ganglion. Moreover, headache alleviation of NTG-induced migraine rats was decided by the inhibition of neuroinflammatory responses through FFLSP’s interruptive effect on the TLR4/MyD88/MAPKs pathway. FFLSP should be attentively considered as a potential therapeutic agent for chronic migraine by blocking inflammatory signal pathway in dura mater and trigeminal ganglion.
{"title":"Fu-Fang-Li-Shao Pill alleviates neuroinflammation through blocking TLR4/MyD88/MAPKs pathway in chronic migraine rats","authors":"Jianmei Yang , Yining Gu , Guang Yang , Waimao Gao , Lei Chen , Yiyun Bao , Kai Meng , Lingyan Zhu , Tengteng Zhou , Xingyu Wang , Ying Xu","doi":"10.1016/j.bbii.2025.100105","DOIUrl":"10.1016/j.bbii.2025.100105","url":null,"abstract":"<div><div>Neuroinflammation is supposed to be a crucial factor in the pathophysiology of migraine, which is caused by intracranial vasodilation and the release of vasoactive peptides. Fu-Fang-Li-Shao Pill (FFLSP), a prescription composed of Tribulus terrestris, Radix Paeoniae Alba, Radix Puerariae, Radix Salviae Miltiorrhizae, White Chrysanthemum, Uncariae Ramulus Cum Uncis, Concha Margaritifera, Fructus Viticis, Angelica Dahurica and Mentha Haplocalyx Briq, is an effective proved recipe for migraine patients which is developed by Shanghai Xuhui District Central Hospital. However, the pharmacological mechanisms of FFLSP in relieving migraine are not well understood. This study aims to assess the therapeutic effect of FFLSP on chronic migraine and to elucidate the underlying mechanisms. In our study, through the repeated subcutaneous injection of nitroglycerin (NTG), an animal model of chronic migraine was established which showed migraine-like symptoms such as head pain, ear redness and irritability. Here, NTG-induced chronic migraine rats were used to evaluate the inhibitory effect of FFLSP on neuroinflammation by conducting behavioral tests and molecular biology analyses. We observed that FFLSP possesses an excellent ability to relieve chronic migraine. FFLSP treatment was able to inhibit vasodilation by decreasing c-Fos and CGRP expressions in dura mater and trigeminal ganglion. Moreover, headache alleviation of NTG-induced migraine rats was decided by the inhibition of neuroinflammatory responses through FFLSP’s interruptive effect on the TLR4/MyD88/MAPKs pathway. FFLSP should be attentively considered as a potential therapeutic agent for chronic migraine by blocking inflammatory signal pathway in dura mater and trigeminal ganglion.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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