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The efficacy and safety of a homeopathic gel in the treatment of acute low back pain: a multi-centre, randomised, double-blind comparative clinical trial 顺势疗法凝胶治疗急性腰痛的有效性和安全性:一项多中心、随机、双盲对照临床试验
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0460
C Stam , MS Bonnet , RA van Haselen

Acute low back pain is a very common condition in Western industrialised countries. In most cases analgesics or topical medications are prescribed at first encounter with the general practitioner (GP).

The aim of this study was to investigate whether the homeopathic gel Spiroflor SRL® gel (SRL) is equally effective and better tolerated than Cremor Capsici Compositus FNA (CCC) in patients with acute low back pain.

A multi-centre, randomised, double-blind, controlled clinical trial was conducted in the practices of 19 GPs in the districts of Bristol and Manchester, UK. One hundred and sixty-one subjects suffering from acute low back pain were treated for one week either with SRL or with CCC. Pain was scored on a 100 mm visual analogue scale (VAS). Main efficacy parameter VAS reduction was compared between treatments. Evaluation of safety was primarily based on the number of subjects with adverse events (AEs), withdrawals due to an AE and adverse drug reactions (ADRs).

The mean difference between the VAS reduction in the SRL group and the CCC group adjusted for VAS at baseline and age was −0.6 mm (90%CI=−6.5–5.3 mm). Fewer subjects in the SRL group (11%) experienced an AE than in the CCC group (26%). The same applies to the number of subjects with an ADR (3/81=4% vs 18/74=24%) and the number of subjects withdrawn due to an ADR (0/81=0% vs 8/74=11%).

In conclusion, SRL and CCC are equally effective in the treatment of acute low back pain, however, SRL has a better safety profile. Spiroflor SRL® gel is preferable to Capsicum-based products for the topical treatment of low back pain, because of the lower risk of adverse effects.

在西方工业化国家,急性腰痛是一种非常常见的疾病。在大多数情况下,止痛药或局部药物是在第一次遇到全科医生(GP)时开的。本研究的目的是探讨顺势疗法凝胶Spiroflor SRL®凝胶(SRL)是否与Cremor Capsici Compositus FNA (CCC)在急性腰痛患者中的疗效相同且耐受性更好。在英国布里斯托尔和曼彻斯特地区的19名全科医生的实践中进行了一项多中心、随机、双盲、对照临床试验。161名急性腰痛患者分别用SRL或CCC治疗一周。疼痛以100 mm视觉模拟评分(VAS)进行评分。比较两组间主要疗效指标VAS降低情况。安全性评估主要基于受试者不良事件(AE)、AE引起的停药和药物不良反应(adr)的数量。SRL组和CCC组在基线和年龄时VAS降低的平均差异为- 0.6 mm (90%CI= - 6.5-5.3 mm)。SRL组(11%)发生AE的受试者少于CCC组(26%)。发生ADR的受试者数量(3/81=4% vs 18/74=24%)和因ADR退出的受试者数量(0/81=0% vs 8/74=11%)也是如此。综上所述,SRL和CCC在治疗急性腰痛方面同样有效,但SRL的安全性更高。由于不良反应的风险较低,Spiroflor SRL®凝胶比基于辣椒的产品更适合局部治疗腰痛。
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引用次数: 40
On the investigation of homeopathic potencies using low resolution NMR T2 relaxation times: an experimental and critical survey of the work of Roland Conte et al 利用低分辨率核磁共振T2松弛时间对顺势疗法效力的研究:Roland Conte等人工作的实验和批判性调查
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0457
LR Milgrom , KR King , J Lee , AS Pinkus

We have attempted to reproduce differences in low resolution nuclear magnetic resonance (NMR) T2 spin–spin relaxation times between homeopathically potentised and unpotentised Nitric acid (nit-ac) solutions previously reported by Conte, et al. Using similar instrumentation and experimental protocols, we have shown that it is likely that Conte's original results are attributable to experimental artifact originating in the glassware used for the manufacture of the NMR tubes.

我们试图重现低分辨率核磁共振(NMR) T2自旋-自旋弛豫时间在顺势疗法增强和未增强的硝酸(nitac)溶液之间的差异,之前Conte等人报道过。使用类似的仪器和实验方案,我们已经表明,孔蒂的原始结果很可能归因于源自用于制造核磁共振管的玻璃器皿的实验人工制品。
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引用次数: 50
Clinical verification of symptom pictures of homeopathic medicines 顺势疗法药物症状图片的临床验证
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0459
S Fayeton, M van Wassenhoven

This invitation for co-operation is addressed to all interested groups. Its purpose is data collection for clinical verification of symptoms from homeopathic proving and collection of clinical symptoms not derived from homeopathic pathogenetic trials (provings). To date no consensus exists on this topic. The European Committee for Homoeopathy (ECH) research sub-committee has created a working group on this topic. This paper is the result of a review of papers on the topic, exchanges between members and a meeting.

这一合作邀请是向所有有关团体发出的。其目的是收集顺势疗法证明的临床验证症状的数据,并收集非来自顺势疗法发病试验(证明)的临床症状。迄今为止,在这个问题上还没有达成共识。欧洲顺势疗法委员会(ECH)研究小组委员会就此主题成立了一个工作组。本文是对课题论文的回顾、委员之间的交流和一次会议的结果。
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引用次数: 9
The widow spider Latrodectus tredecimguttatus: source of the remedy Tarentula hispanica? 寡妇蜘蛛tredecimguttatus:补救药Tarentula hispanica的来源?
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0456
C Richardson-Boedler

The European wolf spider, Lycosa tarentula, said to have caused the historical phenomenon of ‘tarantism’, is the official medicinal source of the homeopathic remedy Tarentula hispanica. Yet, scientific evidence links the spider's venomous effects with mild necrotic and minor systemic effects that contrast with the proving symptoms of Tarentula hispanica which show a cerebral and neural component. A comparative investigation by use of toxicological, clinical findings, supported by modern and antique biological texts, as well as homeopathic materia medica, traces the source of the remedy Tarentula hispanica to the Mediterranean widow spider Latrodectus tredecimguttatus, thus warranting a re-evaluation of pharmacological preparation.

欧洲狼蛛Lycosa tarentula,据说引起了“tarantism”的历史现象,是顺势疗法药物tarentula hispanica的官方药用来源。然而,科学证据表明,这种蜘蛛的毒性作用与轻微的坏死和轻微的系统影响有关,这与西班牙塔兰图拉(Tarentula hispanica)的症状相反,后者显示出大脑和神经成分。一项利用毒理学、临床研究结果、现代和古代生物学文献以及顺势疗法药物支持的比较研究,将药物Tarentula hispanica的来源追溯到地中海寡妇蜘蛛Latrodectus tredecimguttatus,从而有必要对药理学制剂进行重新评估。
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引用次数: 4
90 years old, and just getting into our stride 90岁了,才刚步入正轨
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0462
Peter Fisher
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引用次数: 1
International press abstracts 国际新闻摘要
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0444
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引用次数: 0
20 years ago: The British Homoeopathic Journal, January 1981 20年前:英国顺势疗法杂志,1981年1月
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0453
ST Land
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引用次数: 0
Cushing's Disease: a new approach to therapy in equine and canine patients 库欣病:治疗马和犬病人的新方法
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0450
M Elliott

Forty-one cases of Cushing's Disease affecting both equine and canine patients were treated with an identical mixture of two homeopathically prepared remedies (ACTH 30c and Quercus robur 30c), and the clinical improvements seen in the cases assessed. Homeopathy has been described as a medicine that can only be prescribed on the basis of individual symptoms shown, fitting the remedy to the patient, not the disease. The aim of this study was to define whether a standardised approach, using homeopathically prepared remedies, was a valid system of therapy for this disease, and if so, whether results were repeatable between species. The overall success rate for the therapy was 80% and results were broadly similar between the two species, indicating that homeopathy lends itself to the treatment of Cushing's Disease, and also to both cohort studies and group medicine.

用两种顺势疗法(ACTH 30c和栎木30c)的相同混合物治疗41例影响马和犬的库欣病,并在评估的病例中观察到临床改善。顺势疗法被描述为一种只能根据个人症状开处方的药物,适合病人,而不是疾病。本研究的目的是确定使用顺势疗法制剂的标准化方法是否是治疗这种疾病的有效系统,如果是,结果是否在物种之间可重复。治疗的总体成功率为80%,结果在两个物种之间大致相似,表明顺势疗法适用于库欣病的治疗,也适用于队列研究和群体医学。
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引用次数: 23
Software Review 软件评审
Pub Date : 2001-01-01 DOI: 10.1054/homp.1999.0454
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引用次数: 0
Inter-rater reliability of symptom repertorisation: a pragmatic empirical study 症状再现的评鉴者间信度:一项实用实证研究
Pub Date : 2000-10-01 DOI: 10.1054/homp.1999.0414
AJ Vickers, RA van Haselen , L Pang, S Berkovitz

Objective: To determine the extent to which two homeopaths agree on whether symptoms reported by patients in a proving are possibly associated with Mercurius solubilis.

Design: Blinded, inter-rater reliability study.

Participants: 104 subjects in a randomised, double-blind mercury proving.

Outcome measures: 557 symptom episodes spontaneously reported by subjects were classified as ‘mercury’ or ‘not mercury’ by two homeopaths working blind to each other's conclusions and to patient allocation.

Results: Initial agreement between homeopaths was 70.2%, a kappa of 0.39, (95% CI 0.31, 0.47). Some disagreements appear to have resulted from differing interpretations of the study instructions. After suitable correction, agreement was 76.5% and kappa 0.56 (95% CI 0.49, 0.63).

Conclusions: The study homeopaths had only a moderate level degree of agreement greater than that expected by chance. The main factor seems to have been differences between data from different sources. There is an urgent need for more research on the methods of choosing homoeopathic medicines in order to improve the reliability and validity of homoeopathic diagnoses.

目的:确定两名顺势疗法医生在证明患者报告的症状是否可能与溶汞有关方面的一致程度。设计:盲法、评估者间信度研究。参与者:104名随机双盲汞试验受试者。结果测量:两名顺势疗法医生对彼此的结论和患者分配一无所知,将受试者自发报告的557次症状发作归类为“汞”或“非汞”。结果:顺势疗法患者之间的初始一致性为70.2%,kappa为0.39 (95% CI 0.31, 0.47)。一些分歧似乎是由于对学习说明的不同解释造成的。经过适当的校正后,一致性为76.5%,kappa为0.56 (95% CI 0.49, 0.63)。结论:研究中顺势疗法医师的一致性仅为中等程度,高于偶然预期。主要因素似乎是来自不同来源的数据之间的差异。为了提高顺势疗法诊断的信度和效度,迫切需要对顺势药物的选择方法进行更多的研究。
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引用次数: 8
期刊
British Homoeopathic Journal
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