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Professionals' perceptions of type 2 diabetes in primary care during a service redesign 服务重新设计期间专业人员对初级保健中2型糖尿病的看法
Pub Date : 2012-03-01 DOI: 10.1002/EDN.196
J. McDowell, Kathryn Inverarity, H. Gilmour, G. Lindsay
AbstractThe purpose of this study was to survey primary health care professionals’ perceptions of type 2 diabetes, an evaluation during a service redesign. Management of people with type 2 diabetes has been led by hospital based secondary care. The objective of the service redesign was to transfer the management of the majority of people with type 2 diabetes from secondary care to general practitioner (GP) led, multidisciplinary primary care (comprising the GP, practice nurses, dietitians and podiatrists) delivered closer to the patients. Prior to implementation, all primary health care professionals undertook accredited educational preparation and there was infrastructure development by the creation of new posts and streamlining of IT systems to support the planned change.The study aim was to examine health care professionals’ perspectives of diabetes, its management, the value of clinical guidelines and the impact of practice organisation.A cross-sectional survey design was used. Primary health care pro...
摘要本研究的目的是调查初级卫生保健专业人员对2型糖尿病的看法,在服务重新设计期间进行评估。2型糖尿病患者的管理一直以医院为基础的二级保健为主。服务重新设计的目标是将大多数2型糖尿病患者的管理从二级保健转移到全科医生(GP)领导的多学科初级保健(包括全科医生、执业护士、营养师和足病医生),提供更接近患者的服务。在实施之前,所有初级保健专业人员都进行了经认可的教育准备,并通过设立新职位和精简信息技术系统来发展基础设施,以支持计划的变革。研究的目的是检查卫生保健专业人员对糖尿病的看法,其管理,临床指南的价值和实践组织的影响。采用横断面调查设计。初级卫生保健专业人员
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引用次数: 4
Inspiration for the future 对未来的启发
Pub Date : 2012-03-01 DOI: 10.1002/EDN.195
G. Hood
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引用次数: 1
Benefit by sharing 分享利益
Pub Date : 2011-11-28 DOI: 10.1002/edn.185
B Vrijhoef

Productive interactions are necessary to prevent serious complications from occurring, as is a shared vision on how to meet the obvious targets. Doesn't this look common to what we are trying to achieve in diabetes care? One way of getting there is by sharing information in order to learn from each other. This is exactly what EDN aims to achieve. Not to solve the euro crisis, but to strengthen diabetes nursing across Europe. Then again, with over 60 million people who live with diabetes in Europe, evidence-based care does have significant economic and other implications.

This issue of EDN presents very interesting pieces of evidence. Huber et al. shed light on the views held and problems encountered by nurses working in home health care and nursing homes. Clarke reports on associations between personal characteristics and benefits of attendance at CODE, a structured diabetes education programme. Interim results of a study on the contribution of participant-driven patient education to a reduction of new ulceration are presented by Annersten Gershater et al. Diabetes specialist nursing in the UK is systematically reviewed by James. Zhang and Ho report on a case of severe hypoglycaemia in an individual with insulin treated type 2 diabetes, secondary to panhypopituitarism from a Rathke's cyst. Finally, highlights of this year's annual conference of FEND are reported by Rita Forde.

Another, special way of visualising the societal value of diabetes care is by awarding people for their contributions. It is with great pleasure to mention that Brigitte Osterbrink, member of FEND since its foundation, has been given the German Cross of Merit Award. Congratulations to Brigitte!

为了防止发生严重的并发症,有必要进行富有成效的互动,就如何实现明显的目标达成共同的愿景也是必要的。这难道不是我们在糖尿病护理中努力实现的目标吗?实现这一目标的一种方法是分享信息,以便相互学习。这正是EDN要实现的目标。不是为了解决欧元危机,而是为了加强整个欧洲的糖尿病护理。然而,欧洲有超过6000万糖尿病患者,循证护理确实具有重大的经济和其他影响。本期《EDN》提供了一些非常有趣的证据。Huber等人阐明了在家庭保健和养老院工作的护士所持有的观点和遇到的问题。Clarke报告了个人特征和参加CODE(一个结构化的糖尿病教育项目)的益处之间的联系。Annersten Gershater等人提出了一项关于参与者驱动的患者教育对减少新溃疡的贡献的研究的中期结果。詹姆斯系统地回顾了英国的糖尿病专科护理。Zhang和Ho报道了一例胰岛素治疗的2型糖尿病患者继发于Rathke囊肿的全垂体功能低下的严重低血糖。最后,由Rita Forde为我们介绍了本年度会议的亮点。另一种将糖尿病护理的社会价值可视化的特殊方式是对做出贡献的人进行奖励。在此,我们非常高兴地宣布,自成立以来一直担任该组织成员的布里吉特·奥斯特布林克被授予德国十字勋章。祝贺布丽吉特!
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引用次数: 9
Diabetes care of dependent older adults: an exploratory study of nurses' perspectives 赡养老年人糖尿病护理:护士视角的探索性研究
Pub Date : 2011-11-28 DOI: 10.1002/edn.187
C Huber MSc Diabetes, RN, JW Huber PhD, M Shaha PhD, RN

This study aimed to explore nurses' perspectives on diabetes care for dependent older adults in home health care and nursing homes in Switzerland.

Growing numbers of old and very old adults with diabetes need professional care. In home health care older adults are usually in their 70s and in nursing homes they are about 10 years older. Inadequate diabetes care in older people leads to higher complication rates. Little is known about the views held and problems encountered by nurses working in home health care and nursing homes. Empirical information is lacking concerning perceptions of nurses caring for this dependent group.

A descriptive qualitative study of nurses' perspectives on diabetes care was conducted with a purposive sample of 23 nurses caring for dependent older adults with diabetes in one region of Switzerland in 2008–2009. Semi-structured focus group interview data were analysed using thematic content analysis.

Qualitative data analysis of nurses' transcripts elicited four themes: (a) actual situation in diabetes care – concerns about complications, inter-professional dependency, communication and continuity; (b) nurses' experiences – apprehension about varied interest in diabetes, suitability of assessments, and current knowledge of disease and its influence on patient outcomes; (c) barriers to diabetes care – patient isolation, co-morbidities, lack of understanding; and (d) resources for diabetes care – patients' social support, maintaining regular physical activities, adapting care to individuals' needs.

It was concluded that level of communication, continuity of care and professional roles need clarification. Regular exposure to training through different methods would encourage professional and interpersonal skills and possibly will lead to better patient outcomes. Introducing consulting roles for advanced nurse practitioners specialised in diabetes care within home health care and nursing homes may advance diabetes care within these settings. Copyright © 2011 FEND. Published by John Wiley & Sons, Ltd.

本研究旨在探讨护士对瑞士家庭保健和养老院中受抚养老年人糖尿病护理的看法。越来越多的老年和高龄糖尿病患者需要专业护理。在家庭保健中,老年人通常是70多岁,而在疗养院中,他们的年龄大约是10岁。老年人糖尿病护理不足导致更高的并发症发生率。人们对在家庭保健和养老院工作的护士所持有的观点和遇到的问题知之甚少。经验信息缺乏关于护士照顾这一依赖群体的看法。对2008-2009年瑞士某地区23名护理老年糖尿病患者的护士进行了一项关于护士对糖尿病护理观点的描述性定性研究。采用主题内容分析法对半结构化焦点小组访谈数据进行分析。对护士笔录进行定性数据分析,得出四个主题:(a)糖尿病护理的实际情况——对并发症、专业间依赖、沟通和连续性的关注;(b)护士的经验——了解对糖尿病的不同兴趣、评估的适用性、当前对疾病的了解及其对患者预后的影响;(c)糖尿病护理的障碍——患者隔离、合并症、缺乏了解;(d)糖尿病护理资源——患者的社会支持,保持定期的身体活动,使护理适应个人需求。结论是,需要澄清沟通水平、护理的连续性和专业作用。通过不同的方法定期接受培训,可以提高专业技能和人际交往能力,并可能带来更好的治疗效果。在家庭保健和养老院中为专门从事糖尿病护理的高级护士引入咨询角色可能会促进这些环境中的糖尿病护理。版权所有©2011中华生态科学研究院。John Wiley &出版;儿子,有限公司
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引用次数: 9
Patient education for the prevention of diabetic foot ulcers 预防糖尿病足溃疡的患者教育
Pub Date : 2011-11-28 DOI: 10.1002/edn.189
M Annersten Gershater RN, MNSc, PhD, E Pilhammar RN, PhD, J Apelqvist MD, PhD, C Alm-Roijer RN, PhD

This study was designed to explore whether participant-driven patient education in group sessions, compared to provision of standard information, will contribute to a statistically significant reduction in new ulceration during 24 months in patients with diabetes and high risk of ulceration. This is an interim analysis after six months.

A randomised controlled study was designed in accordance with CONSORT criteria. Inclusion criteria were: age 35–79 years old, diabetes mellitus, sensory neuropathy, and healed foot ulcer below the ankle; 657 patients (both male and female) were consecutively screened.

A total of 131 patients (35 women) were included in the study. Interim analysis of 98 patients after six months was done due to concerns about the patients' ability to fulfil the study per protocol. After a six-month follow up, 42% had developed a new foot ulcer and there was no statistical difference between the two groups. The number of patients was too small to draw any statistical conclusion regarding the effect of the intervention. At six months, five patients had died, and 21 had declined further participation or were lost to follow up. The main reasons for ulcer development were plantar stress ulcer and external trauma.

It was concluded that patients with diabetes and a healed foot ulcer develop foot ulcers in spite of participant-driven group education as this high risk patient group has external risk factors that are beyond this form of education. The educational method should be evaluated in patients with lower risk of ulceration. Copyright © 2011 FEND. Published by John Wiley & Sons, Ltd.

本研究旨在探讨在小组会议中,与提供标准信息相比,参与者驱动的患者教育是否有助于在24个月内显著减少糖尿病和溃疡高风险患者的新发溃疡。这是六个月后的中期分析。根据CONSORT标准设计一项随机对照研究。纳入标准:年龄35-79岁,糖尿病,感觉神经病变,踝关节以下足部溃疡愈合;连续筛查657例患者(男女均有)。131名患者(35名女性)被纳入研究。由于考虑到患者在每个方案中完成研究的能力,对6个月后的98例患者进行了中期分析。在六个月的随访后,42%的人患上了新的足部溃疡,两组之间没有统计学差异。患者数量太少,无法得出有关干预效果的统计结论。6个月时,5名患者死亡,21名患者拒绝进一步参与或失去随访。溃疡发生的主要原因是足底应激性溃疡和外伤。结论是,尽管进行了参与者驱动的群体教育,但糖尿病和足溃疡愈合的患者仍会发生足溃疡,因为这一高危患者群体具有超出这种教育形式的外部危险因素。对于溃疡发生风险较低的患者,应评估教育方法。版权所有©2011中华生态科学研究院。John Wiley &出版;儿子,有限公司
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引用次数: 47
Houssay phenomenon: a rare case of diabetes mellitus remission 豪赛现象:糖尿病缓解的罕见病例
Pub Date : 2011-11-28 DOI: 10.1002/edn.191
JTW Zhang BSc(Med), MBBS, KWK Ho MBBS(Hons), FRACP, PhD

Hypoglycaemia in a type 2 diabetes patient can be due to oral hypoglycaemic agent(s), in particular sulphonylureas, or insulin therapy. Pituitary dysfunction is a less common, yet important, cause of severe hypoglycaemia. Associated features include nausea, dizziness, hypotension, and hyponatraemia.

We describe a case of severe hypoglycaemia in an individual with insulin treated type 2 diabetes, secondary to panhypopituitarism from a Rathke's cyst. A brief overview on Rathke's cysts is provided. Copyright © 2011 FEND. Published by John Wiley & Sons, Ltd.

2型糖尿病患者的低血糖可由口服降糖药,特别是磺脲类药物或胰岛素治疗引起。垂体功能障碍是一种不太常见,但重要的严重低血糖的原因。相关特征包括恶心、头晕、低血压和低钠血症。我们描述了一例严重的低血糖患者与胰岛素治疗的2型糖尿病,继发于从Rathke的囊肿全垂体功能低下。简要概述Rathke囊肿提供。版权所有©2011中华生态科学研究院。John Wiley &出版;儿子,有限公司
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引用次数: 4
UN high level summit on NCDs 联合国非传染性疾病高级别峰会
Pub Date : 2011-11-28 DOI: 10.1002/edn.186
A-M Felton

In the three round table discussions, the statements read by government representatives recognised the magnitude and impact of the NCD global challenge. There was no opportunity given to discuss possible solutions among those participating in these round tables. It was an opportunity lost and in fact a number of government representatives expressed this disappointment. In my view, the title ‘round table discussion’ was misleading.

Each government representative was permitted to make a three-minute statement and, because of the large number of statements, this consumed valuable time which might have been spent in a more worthwhile way in discussion regarding solutions but this appears to be the way in which UN ‘round tables’ are conducted. It was also the experience of FEND representatives at the informal civil society meeting at the UN in June.

Dr Margaret Chan, Director General of WHO, called the meeting a ‘watershed event’ during her plenary address at the opening of the summit. Many of the government representatives who spoke indicated their awareness of the impact of NCDs in their own countries, and in some cases committed to additional funding and action plans to specific programmes relating to NCD prevention and control. WHO will be the central agency co-ordinating action post following on from this summit in preparation for a formal report by the end of 2012.

It follows that civil society organisations including FEND should now engage with their national governments because it is there that the responsibility lies. So the work of advocacy must continue. The International Diabetes Federation, as a member of the NCD group, will be addressing the key issues in relation to the deficits in the political declaration as well as ensuring that governments who have made commitments during the UN HLM are held to account.

FEND will engage with WHO through the offices of Dr Ala Alwan, Assistant Director General of WHO with special responsibility for NCDs. FEND aims to offer its expertise in the field of diabetes nursing in addressing this major disease of the NCD group. We will keep you informed with regard to the response of WHO to this offer.

The full political declaration can be viewed in six languages at: www.un.org/Docs/journal/asp/ws.asp?m=A/66/L.1. Other documents can be found at: www.un.org/en/ga/ncdmeeting2011/documents.shtml.

Furthermore, you can also view the webcasts of the plenary and round tables at: www.unmultimedia.org/tv/webcast/c/ncdmeeting2011.html.

FEND was the only nursing organisation represented in the civil society groups.

At the time of writing, World Diabetes Day approaches on 14 November. I wish you all a successful day in promoting awareness of the burden of diabetes in your respective countries, and continued success in your advocacy for people with diabetes.

在三次圆桌讨论中,政府代表宣读的声明承认非传染性疾病全球挑战的规模和影响。参加这些圆桌会议的人没有机会讨论可能的解决办法。这是一个失去的机会,事实上,一些政府代表表达了这种失望。在我看来,“圆桌讨论”的标题具有误导性。每个政府代表都被允许作三分钟的发言,由于发言的数量很多,这消耗了宝贵的时间,这些时间本可以用更有价值的方式来讨论解决方案,但这似乎是联合国“圆桌会议”的进行方式。这也是6月联合国民间社会非正式会议上民盟代表的经验。世卫组织总干事陈冯富珍博士在首脑会议开幕式的全体讲话中称这次会议是一次“分水岭事件”。许多发言的政府代表表示,他们意识到非传染性疾病在本国的影响,并在某些情况下承诺为与非传染性疾病预防和控制有关的具体方案提供额外资金和行动计划。世卫组织将是本次首脑会议之后协调行动的中央机构,准备在2012年底之前提交一份正式报告。由此可见,包括绿色和平联盟在内的民间社会组织现在应该与他们的国家政府接触,因为责任就在那里。因此,宣传工作必须继续下去。作为非传染性疾病小组的成员,国际糖尿病联合会将处理与政治宣言中的缺陷有关的关键问题,并确保在联合国高级别会议期间作出承诺的政府承担责任。非洲免疫联盟将通过世卫组织特别负责非传染性疾病的助理总干事Ala Alwan博士的办公室与世卫组织进行接触。该联盟旨在提供其在糖尿病护理领域的专业知识,以应对非传染性疾病群体中的这一主要疾病。我们将随时向你通报世卫组织对这一提议的反应。《政治宣言》全文可在以下网址查阅:www.un.org/Docs/journal/asp/ws.asp?m=A/66/L.1。其他文件可在www.un.org/en/ga/ncdmeeting2011/documents.shtml.Furthermore上找到,您也可以在www.unmultimedia.org/tv/webcast/c/ncdmeeting2011.html.FEND上查看全体会议和圆桌会议的网络广播,我们是民间社会团体中唯一有代表的护理组织。在撰写本文时,11月14日是世界糖尿病日。我祝你们在各自国家提高对糖尿病负担的认识方面取得成功,并祝你们在为糖尿病患者宣传方面继续取得成功。
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引用次数: 0
FEND Conference 2011 2011年中国农业发展联盟会议
Pub Date : 2011-11-28 DOI: 10.1002/edn.192
R Forde

The opening address given by the Chairperson, Deirdre Kyne-Grzebalski, welcomed those present to a programme representing a cross-section of diabetes topics and speakers. The President of FEND, Anne-Marie Felton, emphasised the role of diabetes nursing as not solely clinical and research but also having an advocacy responsibility for all people living with diabetes.

The co-ordinator of the Portuguese Diabetes Association, Dr Boavida, gave a review of the impact diabetes has on the Portuguese population. He also outlined the National Diabetes Prevention programme which began in 2008 and which is aiming to reduce the incidence of diabetes in the Portuguese population. According to Lurdes Serrabulho, diabetes nursing in Portugal was recognised in the 1970s; however, a dedicated course for this specialty did not commence until more than two decades later. Patient education has been a focal aspect of care in Portugal with the world's first Diabetes Association being established in Lisbon in 1929 under the guidance of Dr Ernesto Roma.

The Leuven model of diabetes care in the ICU setting was presented by Koen Vanhonsebrouck. This model was the basis of the first randomised controlled trial on the management of glycaemia in the intensive care setting and confirmed the positive impact of maintaining near normal blood glucose levels on mortality and morbidity. While other studies have argued against tight glycaemic control in this patient cohort, fundamental differences were identified in these studies, such as technology and education of staff.

Dr Peter Adolfsson from Sweden presented on the effects and benefits of exercise in people with diabetes. In general, people living with diabetes tend to be less active than their non-diabetes counterparts. It is thought that fear of hypoglycaemia is a contributing factor. While glucose values are dependent on the intensity and the duration of the exercise, several other factors come into play such as the person's insulin sensitivity and dietary intake prior to, during and after the exercise. He explained the complex hormonal adaptation that occurs during exercise. The use of technology such as insulin pumps and glucose sensors have a place; however, when used he encouraged the trends to be analysed and the patients to be coached in the interpretation.

Prof Angus Forbes gave his overview of training of diabetes nurse specialists utilising the FEND ENDCUP model. He acknowledged that the training of diabetes health care professionals (HCPs) is variable across Europe; however, some fundamental aspects should be universal such as analysing the learning in order to achieve clinical competence and clinical performance. The FEND ENDCUP model strives for not only clinical excellence but also education and research excellence.

The management of severe obesity, which is at the extreme end of the spectrum of obesity, requires a dedicated multidisciplinary team approach. Dr O'Connell outlined t

联合国非传染性疾病问题首脑会议于9月19日至20日在纽约举行。Anne-Marie Felton概述了希望在本次会议上取得的成果,并建议这是影响后代糖尿病护理的独特全球机会。她敦促所有与会者与本国组织接触,鼓励国家一级的政治参与。第二天,丽塔·福德(Rita Forde)就为什么糖尿病女性应该投资于怀孕计划进行了发言。尽管有大量证据支持在怀孕前实现良好的血糖控制的重要性,但事实仍然是,重大先天性畸形仍然是糖尿病妇女的婴儿严重死亡和发病的主要原因。文中给出了爱尔兰都柏林Mater医院专门的孕前诊所如何解决这一问题的一个例子。Henja Westerbeek概述了专业营养师对持续皮下胰岛素泵治疗和每日多次注射治疗的糖尿病管理的价值。他们强调了碳水化合物计数和区分食物组的教育的好处,特别提到了这些知识如何告知糖尿病患者如何适当地自我调整他们的膳食胰岛素剂量。有八个海报口头介绍,代表了七个国家,涵盖了不同环境下糖尿病护理和教育的各个方面。大师班涉及糖尿病护理的两个不同方面。来自里斯本葡萄牙糖尿病协会的一个团队,基于卡尔加里模型、行为改变模型、动机访谈和他们的个人经验,提出了一个治疗性患者教育模型。他们的模型有六个阶段,即:相遇;了解对方;建立关系;相互理解;决策谈判策略;分离——咨询的结束。同时,大师班的重点是低血糖和低血糖意识工具包的发展。Claus Juhl博士概述了低血糖的临床症状和生化信号,以及用来教育人们低血糖的策略。他概述了胰岛素泵和连续葡萄糖传感器的好处,最后,Juhl博士讨论了一种对大脑中的电活动做出反应的创新设备;然而,虽然这种新设备对那些经常患有严重低血糖的人来说是一个令人兴奋的前景,但目前还不容易获得。活动一直持续到午餐时间,由安格斯·福布斯教授主持召开了首届生态环境研究网络小组会议。该小组确定了可以以合作方式解决的目标和研究重点。来自英国纽卡斯尔的James Shaw教授谈到了胰岛细胞移植作为一种临床证实的治疗严重低血糖的益处,并概述了英国胰岛移植联盟的运作方式。在英国几个中心的合作下,胰岛细胞已经成功地在中心之间运输,在临床移植治疗严重的衰弱性低血糖之前进行体外操作。然而,这种治疗还处于起步阶段,在广泛应用于对传统医疗管理无反应的复杂1型糖尿病患者之前,还需要进一步的研究。最后的全体会议由瑞士的Iselin博士主持,讨论了在欧洲人口老龄化中管理糖尿病的挑战。他鼓励所有照顾老年糖尿病患者的医护人员认识到他们以前的学习和生活经历,但也要意识到由于年龄增长而潜在的认知缺陷。本次会议圆满结束,并举行了最佳海报颁奖典礼和年度糖尿病教育研究小组颁奖典礼。闭幕致词后,主席宣布将于2012年9月28日至29日在柏林举行第十七届绿色发展联盟年会。
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引用次数: 0
FEND news 保护新闻
Pub Date : 2011-11-28 DOI: 10.1002/edn.184
D Kyne-Grzebalski

Our Professor in Diabetes Nursing, Angus Forbes, has been busy this year with the successful launch of the new ENDCUP Programme, which comprised a summer school completed in July and an ongoing e-learning programme. A number of students from Europe and other countries in the world took part in the programme, and on completion will receive a postgraduate certificate in clinical diabetes management.

The conference, held in Lisbon this year, was once again well attended (>650 delegates) and highly evaluated. The programme was very well received with exceptional speakers who delivered highly appropriate and stimulating presentations. Rita Forde, a former committee member of FEND, has written an excellent report outlining the main points from the meeting (see page 117).

The journal continues to go from strength to strength with three issues published each year. I hope you are continuing to think of the journal first for any original work or innovations in practice you may wish to share. The editors are working hard to obtain index submission for the journal.

FEND, through you the members, continues to promote World Diabetes Day, and we trust that this year it will be another successful day highlighting the important issues of education and prevention.

FEND continues to work in collaboration with other European organisations to make up the European Coalition for Diabetes (ECD). The objective of this group is to improve prevention of diabetes, as well as the health and quality of life of European citizens living with diabetes, by influencing European Union policy. There is further information in this issue from your President, with regard to the recent United Nations Summit on Non-Communicable Diseases.

We look forward to hearing from you, whether online, through the journal or at our next annual conference. The conference next year will take place on 28 and 29 September 2012 in Berlin.

我们的糖尿病护理教授安格斯·福布斯(Angus Forbes)今年一直忙于成功启动新的ENDCUP计划,该计划包括7月份完成的暑期学校和正在进行的电子学习计划。许多来自欧洲和世界其他国家的学生参加了该计划,并在完成后将获得临床糖尿病管理的研究生证书。今年在里斯本举行的会议再次吸引了众多与会者(650名代表),并得到了高度评价。节目受到了热烈的欢迎,杰出的演讲者发表了非常恰当和令人振奋的演讲。前生态保护联盟委员会成员Rita Forde撰写了一份出色的报告,概述了会议的要点(见117页)。该杂志不断发展壮大,每年出版三期。我希望你们继续首先想到这本杂志,因为你们可能希望分享任何原创作品或实践中的创新。编辑们正在努力为期刊争取索引投稿。联盟通过各位成员继续推动世界糖尿病日,我们相信,今年的世界糖尿病日将是又一个成功的日子,突出教育和预防的重要问题。欧洲糖尿病防治联盟继续与其他欧洲组织合作,组成欧洲糖尿病联盟(ECD)。该小组的目标是通过影响欧洲联盟的政策,改善糖尿病的预防,以及糖尿病患者的健康和生活质量。贵国主席就最近举行的联合国非传染性疾病问题首脑会议在本期提供了进一步的资料。我们期待着您的来信,无论是在网上、通过期刊还是在我们的下一届年度会议上。明年的会议将于2012年9月28日和29日在柏林举行。
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引用次数: 0
The effects of mixing different insulin analogues 混合不同胰岛素类似物的效果
Pub Date : 2011-11-28 DOI: 10.1002/edn.193
J Hill, R Poole

Frequently doctors, specialist nurses and patients are unaware of the interaction between different insulins. We reviewed a needle phobic patient using a subcutaneous cannula device. The patient was using insulin glargine (Lantus) and insulin aspart (Novorapid). He had been advised to use two separate devices to keep the insulins apart. However, he was using the one device to give both insulin types and had experienced no problems.

Unlike most other insulins which are soluble at a neutral pH, insulin glargine is soluble at a pH of 4. The slightly acidic nature of glargine is the reason it can sting when injected. The manufacturer (Sanofi-Aventis) advises that it is never diluted or mixed with other insulins and that it should only be used if it is clear and colourless with no particles visible.

We demonstrate the effects of mixing insulin glargine with short acting insulin analogues. In each of six 1ml syringes we mixed 50 units of a long acting insulin analogue, either glargine (Lantus) or detemir (Levemir), with 50 units of a short acting analogue: aspart (Novorapid), lispro (Humalog) or glulisine (Apidra).

All of the short acting insulins mixed with insulin glargine immediately formed a cloudy white precipitate which gradually settled at the bottom of the syringe. In contrast, no precipitate was seen with the same short acting analogues mixed with detemir (see Figure 1).

Adding an insulin with a slightly acidic pH on to an insulin with a neutral pH results in a solution with a pH part-way between the two (depending on the proportions of the two insulins). At the new pH, neither insulin will now be soluble. The insulin molecules form crystals which precipitate out of solution. This reduces the effectiveness of the insulin dose.

Subcutaneous cannulae can be useful devices where patients might otherwise omit insulin doses because of needle phobia. Available brands include the Insuflon (Applied Medical Technology Ltd, Cambridge, UK) and the i-port (Patton Medical Devices, Austin, Texas, USA). These can be used for insulin but also for other repeated subcutaneous injections such as growth hormone, heparin, analgesics or G-CSF.

These injection ports reduce pain and anxiety around repeated injections.1 Studies in children show that their use can improve glycaemic control. In one study, HbA1c dropped from 9.4% (79mmol/mol) to 8.5% (69mmol/mol) over six months.2 They are designed to be changed every three to five days. They are not available on prescription on the National Health Service but patients can purchase them. They are not widely used, either because of the cost or because doctors and specialist nurses are unfamiliar with them.

We demonstrate why patients should be advised to use a separate injection port for the two different insulin types, especially if the long acting insulin is glargine. This advice is also relevant to patients injecting the two insulins

医生、专科护士和病人常常不知道不同胰岛素之间的相互作用。我们回顾了一个使用皮下插管装置的针恐惧症患者。患者使用甘精胰岛素(Lantus)和阿斯帕特胰岛素(Novorapid)。医生建议他使用两个单独的装置来隔离胰岛素。然而,他用同一台设备注射两种类型的胰岛素,并没有遇到任何问题。与其他大多数在中性pH下可溶的胰岛素不同,甘精胰岛素在pH为4时可溶。甘精的微酸性是注射时刺痛的原因。制造商(赛诺菲-安万特)建议,它永远不会被稀释或与其他胰岛素混合,只有在透明无色,没有可见颗粒的情况下才能使用。我们证明混合甘精胰岛素与短效胰岛素类似物的效果。在6支1ml注射器中,我们将50单位长效胰岛素类似物甘精氨酸(Lantus)或地替米(Levemir)与50单位短效胰岛素类似物:阿斯帕特(Novorapid)、利斯普罗(Humalog)或甘氨酸(Apidra)混合在一起。所有短效胰岛素与甘精胰岛素混合后立即形成浑浊的白色沉淀物,逐渐沉淀在注射器底部。相反,将同样的短效类似物与德特米尔混合后,没有发现沉淀(见图1)。将pH值为微酸性的胰岛素加入pH值为中性的胰岛素,会得到pH值介于两者之间的溶液(取决于两种胰岛素的比例)。在新的pH值下,两种胰岛素都不能溶解。胰岛素分子形成晶体,从溶液中沉淀出来。这降低了胰岛素剂量的有效性。皮下插管是一种有用的装置,否则患者可能会因为针头恐惧症而忽略胰岛素剂量。现有品牌包括Insuflon(应用医疗技术有限公司,剑桥,英国)和i-port(巴顿医疗设备公司,奥斯汀,德克萨斯州,美国)。这些可用于胰岛素,但也可用于其他重复皮下注射,如生长激素、肝素、镇痛药或G-CSF。这些注射口减少了反复注射时的疼痛和焦虑对儿童的研究表明,它们的使用可以改善血糖控制。在一项研究中,HbA1c在六个月内从9.4% (79mmol/mol)下降到8.5% (69mmol/mol)它们被设计成每三到五天更换一次。英国国家医疗服务体系(National Health Service)不提供处方,但患者可以购买。它们没有被广泛使用,要么是因为成本太高,要么是因为医生和专科护士对它们不熟悉。我们论证了为什么建议患者使用单独的注射口注射两种不同类型的胰岛素,特别是长效胰岛素是甘精胰岛素。这一建议也适用于用胰岛素笔注射这两种胰岛素的患者。两次注射应在两个不同的部位进行,因为胰岛素晶体的沉淀可能发生在皮下层内。我们希望通过发表这篇文章,我们能启发更多的医生和专业护士,以确保他们的病人保持Lantus注射部位轮换,而不是短效胰岛素注射部位轮换。没有宣布任何利益冲突。
{"title":"The effects of mixing different insulin analogues","authors":"J Hill,&nbsp;R Poole","doi":"10.1002/edn.193","DOIUrl":"10.1002/edn.193","url":null,"abstract":"<p>Frequently doctors, specialist nurses and patients are unaware of the interaction between different insulins. We reviewed a needle phobic patient using a subcutaneous cannula device. The patient was using insulin glargine (Lantus) and insulin aspart (Novorapid). He had been advised to use two separate devices to keep the insulins apart. However, he was using the one device to give both insulin types and had experienced no problems.</p><p>Unlike most other insulins which are soluble at a neutral pH, insulin glargine is soluble at a pH of 4. The slightly acidic nature of glargine is the reason it can sting when injected. The manufacturer (Sanofi-Aventis) advises that it is never diluted or mixed with other insulins and that it should only be used if it is clear and colourless with no particles visible.</p><p>We demonstrate the effects of mixing insulin glargine with short acting insulin analogues. In each of six 1ml syringes we mixed 50 units of a long acting insulin analogue, either glargine (Lantus) or detemir (Levemir), with 50 units of a short acting analogue: aspart (Novorapid), lispro (Humalog) or glulisine (Apidra).</p><p>All of the short acting insulins mixed with insulin glargine immediately formed a cloudy white precipitate which gradually settled at the bottom of the syringe. In contrast, no precipitate was seen with the same short acting analogues mixed with detemir (see Figure 1).</p><p>Adding an insulin with a slightly acidic pH on to an insulin with a neutral pH results in a solution with a pH part-way between the two (depending on the proportions of the two insulins). At the new pH, neither insulin will now be soluble. The insulin molecules form crystals which precipitate out of solution. This reduces the effectiveness of the insulin dose.</p><p>Subcutaneous cannulae can be useful devices where patients might otherwise omit insulin doses because of needle phobia. Available brands include the Insuflon (Applied Medical Technology Ltd, Cambridge, UK) and the i-port (Patton Medical Devices, Austin, Texas, USA). These can be used for insulin but also for other repeated subcutaneous injections such as growth hormone, heparin, analgesics or G-CSF.</p><p>These injection ports reduce pain and anxiety around repeated injections.<span>1</span> Studies in children show that their use can improve glycaemic control. In one study, HbA<sub>1c</sub> dropped from 9.4% (79mmol/mol) to 8.5% (69mmol/mol) over six months.<span>2</span> They are designed to be changed every three to five days. They are not available on prescription on the National Health Service but patients can purchase them. They are not widely used, either because of the cost or because doctors and specialist nurses are unfamiliar with them.</p><p>We demonstrate why patients should be advised to use a separate injection port for the two different insulin types, especially if the long acting insulin is glargine. This advice is also relevant to patients injecting the two insulins","PeriodicalId":100496,"journal":{"name":"European Diabetes Nursing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/edn.193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84301825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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European Diabetes Nursing
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