Pub Date : 2020-03-02DOI: 10.3760/CMA.J.ISSN.0254-1416.2020.02.015
Jing-li Chen, Pu Ma, Chang Liu, Hong Yan
{"title":"Anesthetic management of a patient with COVID-19 under incubation period undergoing total hip arthroplasty","authors":"Jing-li Chen, Pu Ma, Chang Liu, Hong Yan","doi":"10.3760/CMA.J.ISSN.0254-1416.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2020.02.015","url":null,"abstract":"","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48950354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-1416.2020.0006
Zhi-qiang Zhou, Xingxing Sun, Shiyong Li, L. Wan, A. Luo, Dongji Han
Thirty-six puerperas who underwent emergency cesarean section at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 24, 2020 to February 9, 2020, who all wore medical surgical masks, were retrospectively included in this study. Anesthesia management was performed under tertiary medical protection measures. A dedicated anesthesia equipment was separately sterilized. Narcotic drugs were used for one patient only, and disposable medical supplies were used for anesthetic supplies. Contact transmission should be avoided when a neonate required resuscitation, and early isolation and nucleic acid testing were provided for the neonates. The rate of suspected cases of novel coronavirus (2019-nCoV) was 11% , and the rate of clinically diagnosed cases was 17% before surgery. The rate of clinically diagnosed cases of 2019-nCoV was 22%, the rate of confirmed cases was 8%, and the total positive rate of diagnosis was 31% after surgery. The rate of neuraxial anesthesia was 86%, the rate of general anesthesia was 14%, the time of spinal puncture was (15±7) min, the time of tracheal intubation under general anesthesia was (2.1±1.3) min, the operation time was (95±36) min, and blood loss was (276±166) ml. The Apgar score of newborns was 8.8 ± 0.5. There was 1 neonate whose mother was diagnosed as having 2019 novel coronavirous disease after operation, an oropharyngeal swab specimen was obtained at 36 h of birth, and the swab was tested positive for 2019-nCoV by nucleic acid testing. As of February 10, 2020, an anesthesiologist involved in the operation was diagnosed to have infection by 2019-nCoV. In conclusion, diagnosis of 2019 novel coronavirous disease during pregnancy is more difficult, it is necessary to perform anesthesia management for cesarean section under tertiary medical protection. Although the difficulty in anesthesia operation is increased under tertiary medical protection, anesthesiologists can carry out standardized anesthesia management and guarantee the safety of maternal and infants and anesthesiologists themselves as long as they are rigorously trained and adhere to protective protocols. Key words: COVID-19; Cesarean section; Anesthesia
{"title":"Anesthesia management for cesarean section during novel coronavirous epidemic/ 中华麻醉学杂志","authors":"Zhi-qiang Zhou, Xingxing Sun, Shiyong Li, L. Wan, A. Luo, Dongji Han","doi":"10.3760/CMA.J.ISSN.0254-1416.2020.0006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2020.0006","url":null,"abstract":"Thirty-six puerperas who underwent emergency cesarean section at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 24, 2020 to February 9, 2020, who all wore medical surgical masks, were retrospectively included in this study. Anesthesia management was performed under tertiary medical protection measures. A dedicated anesthesia equipment was separately sterilized. Narcotic drugs were used for one patient only, and disposable medical supplies were used for anesthetic supplies. Contact transmission should be avoided when a neonate required resuscitation, and early isolation and nucleic acid testing were provided for the neonates. The rate of suspected cases of novel coronavirus (2019-nCoV) was 11% , and the rate of clinically diagnosed cases was 17% before surgery. The rate of clinically diagnosed cases of 2019-nCoV was 22%, the rate of confirmed cases was 8%, and the total positive rate of diagnosis was 31% after surgery. The rate of neuraxial anesthesia was 86%, the rate of general anesthesia was 14%, the time of spinal puncture was (15±7) min, the time of tracheal intubation under general anesthesia was (2.1±1.3) min, the operation time was (95±36) min, and blood loss was (276±166) ml. The Apgar score of newborns was 8.8 ± 0.5. There was 1 neonate whose mother was diagnosed as having 2019 novel coronavirous disease after operation, an oropharyngeal swab specimen was obtained at 36 h of birth, and the swab was tested positive for 2019-nCoV by nucleic acid testing. As of February 10, 2020, an anesthesiologist involved in the operation was diagnosed to have infection by 2019-nCoV. In conclusion, diagnosis of 2019 novel coronavirous disease during pregnancy is more difficult, it is necessary to perform anesthesia management for cesarean section under tertiary medical protection. Although the difficulty in anesthesia operation is increased under tertiary medical protection, anesthesiologists can carry out standardized anesthesia management and guarantee the safety of maternal and infants and anesthesiologists themselves as long as they are rigorously trained and adhere to protective protocols. \u0000 \u0000 \u0000Key words: \u0000COVID-19; Cesarean section; Anesthesia","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48362128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-24DOI: 10.3760/CMA.J.ISSN.0254-1416.2020.0004
Xiaoxia Peng, L. Nan
During the outbreak and epidemic of novel coronavirus pneumonia, anesthesiologists are not only the high-risk group of secondary infection, but also undertake tasks to initiate clinical research so that the regular pattern of disease could be summarized, which will product clinical evidences for clinical decision-making and optimization of anesthesia therapy as soon as possible. The clinical research evidences of anaesthesia are of great importance for improving the prevention and control strategy of infectious diseases and implementing relevant measures effectively. The recommendations from the epidemiological perspective are provided on how to conduct clinical research on anesthesiology during epidemic of the novel coronavirus pneumonia in the present paper: (1) The case report and case series research should be initiated promptly once the infectious cases treated in anesthesia department are diagnosed; (2) To focus on need of evidence of decision-making of diagnosis and treatment, to summarize general rules timely and to promote the rapidly production of evidence; (3) To establish a special cohort of novel coronavirus pneumonia so that more prognosis studies could be carried out; (4) To explore the risk factors which result in hospital infection among medical staffs so that hospital infection could be controlled. The purpose of this study is to provide clinicians with methodological suggestions on how to carry out high-quality clinical research in the epidemic period of infectious diseases, and to close the gap between clinical and public health. Key words: novel coronavirus pneumonia; case report; clinical research; special cohort; hospital infection
{"title":"How to conduct clinical research on anesthesiology during epidemic of the novel coronavirus pneumonia: recommendations from the epidemiological perspective/ 中华麻醉学杂志","authors":"Xiaoxia Peng, L. Nan","doi":"10.3760/CMA.J.ISSN.0254-1416.2020.0004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2020.0004","url":null,"abstract":"During the outbreak and epidemic of novel coronavirus pneumonia, anesthesiologists are not only the high-risk group of secondary infection, but also undertake tasks to initiate clinical research so that the regular pattern of disease could be summarized, which will product clinical evidences for clinical decision-making and optimization of anesthesia therapy as soon as possible. The clinical research evidences of anaesthesia are of great importance for improving the prevention and control strategy of infectious diseases and implementing relevant measures effectively. The recommendations from the epidemiological perspective are provided on how to conduct clinical research on anesthesiology during epidemic of the novel coronavirus pneumonia in the present paper: (1) The case report and case series research should be initiated promptly once the infectious cases treated in anesthesia department are diagnosed; (2) To focus on need of evidence of decision-making of diagnosis and treatment, to summarize general rules timely and to promote the rapidly production of evidence; (3) To establish a special cohort of novel coronavirus pneumonia so that more prognosis studies could be carried out; (4) To explore the risk factors which result in hospital infection among medical staffs so that hospital infection could be controlled. The purpose of this study is to provide clinicians with methodological suggestions on how to carry out high-quality clinical research in the epidemic period of infectious diseases, and to close the gap between clinical and public health. \u0000 \u0000 \u0000Key words: \u0000novel coronavirus pneumonia; case report; clinical research; special cohort; hospital infection","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42900833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AIDS associated with pneumocystis cariniisevere pneumonia during the epidemic of novel conoraviruspneumonia: one case report","authors":"Yucui Shen, Yu Luo, Jiawei Ren, Jue Zhang, Lize Xiong","doi":"10.3760/CMA.J.ISSN.0254-1416.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2020.02.012","url":null,"abstract":"","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43944100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.3760/CMA.J.ISSN.0254-1416.2020.0001
Lize Xiong
{"title":"Fighting the outbreak of novel coronavirus-infected pneumonia: suggestions to anesthesia practioners","authors":"Lize Xiong","doi":"10.3760/CMA.J.ISSN.0254-1416.2020.0001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2020.0001","url":null,"abstract":"","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47135220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.0254-1416.2019.11.027
Qing Fang, Xiao-jing Wu, Min Yuan, Qian Kong, Huan Luo, Q. Jin, Xuemin Song
Objective To evaluate the effect of dexmedetomidine on acute lung injury (ALI) induced by "double hit" in rats. Methods Forty SPF male Sprague-Dawley rats, aged 8 weeks, weighing 215-225 g, were divided into 4 groups(n=10 each) using a random number table method: sham operation group (Sham group), "double hit" -induced ALI group (ALI group), "double hit" -induced ALI plus dexmedetomidine group (ALI+ Dex group) and "double hit" -induced ALI plus dexmedetomidine plus yohimbine group (ALI+ Dex+ Y group). ALI was induced by blunt chest trauma and hemorrhagic shock-resuscitation in pentobarbital sodium-anesthetized rats in ALI, ALI+ Dex and ALI+ Dex+ Y groups.In group ALI+ Dex, dexmedetomidine was intravenously infused for 10 min in a loading dose of 1 μg·kg-1·h-1 starting from the time point immediately after blunt chest trauma, followed by continuous infusion of 5 μg·kg-1·h-1 until the end of operation.Yohimbine 0.1 mg/kg was injected after giving the loading dose of dexmedetomidine and at 3 h after blunt chest trauma in ALI+ Dex+ Y group.Rats were sacrificed at 6 h after successful establishment of the model, blood samples were obtained for determination of concentrations of TNF-α and IL-6 in serum (by enzyme-linked immunosorbent assay), and lung tissues were obtained for determination of wet/dry weight (W/D) ratio, expression of Fas, FasL and caspase-3 in lung tissues (by SABC assay), cell apoptosis (by TUNEL), content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) and for examination of the pathological changes which were scored.The apoptosis index (AI) was calculated. Results Compared with Sham group, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly increased, and the SOD activity in lung tissues was decreased in ALI group (P<0.05). Compared with ALI group, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly decreased, and the SOD activity in lung tissues was increased in ALI+ Dex and ALI+ Dex+ Y groups (P<0.05). Compared with group ALI+ Dex, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly increased, and the SOD activity in lung tissues was decreased in group ALI+ Dex+ Y (P<0.05). Conclusion Dexmedetomidine reduces ALI induced by "double hit" in rats, and the mechanism may be partially related to activating alpha-2 adrenergic receptor and inhibiting inflammatory responses, lipid peroxidation and cell apoptosis. Key words: Dexmedetomidine; Thoracic injury; Shock, hemorrhagic; Acute lung injury
{"title":"Effect of dexmedetomidine on acute lung injury induced by \"double hit\" in rats","authors":"Qing Fang, Xiao-jing Wu, Min Yuan, Qian Kong, Huan Luo, Q. Jin, Xuemin Song","doi":"10.3760/CMA.J.ISSN.0254-1416.2019.11.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2019.11.027","url":null,"abstract":"Objective \u0000To evaluate the effect of dexmedetomidine on acute lung injury (ALI) induced by \"double hit\" in rats. \u0000 \u0000 \u0000Methods \u0000Forty SPF male Sprague-Dawley rats, aged 8 weeks, weighing 215-225 g, were divided into 4 groups(n=10 each) using a random number table method: sham operation group (Sham group), \"double hit\" -induced ALI group (ALI group), \"double hit\" -induced ALI plus dexmedetomidine group (ALI+ Dex group) and \"double hit\" -induced ALI plus dexmedetomidine plus yohimbine group (ALI+ Dex+ Y group). ALI was induced by blunt chest trauma and hemorrhagic shock-resuscitation in pentobarbital sodium-anesthetized rats in ALI, ALI+ Dex and ALI+ Dex+ Y groups.In group ALI+ Dex, dexmedetomidine was intravenously infused for 10 min in a loading dose of 1 μg·kg-1·h-1 starting from the time point immediately after blunt chest trauma, followed by continuous infusion of 5 μg·kg-1·h-1 until the end of operation.Yohimbine 0.1 mg/kg was injected after giving the loading dose of dexmedetomidine and at 3 h after blunt chest trauma in ALI+ Dex+ Y group.Rats were sacrificed at 6 h after successful establishment of the model, blood samples were obtained for determination of concentrations of TNF-α and IL-6 in serum (by enzyme-linked immunosorbent assay), and lung tissues were obtained for determination of wet/dry weight (W/D) ratio, expression of Fas, FasL and caspase-3 in lung tissues (by SABC assay), cell apoptosis (by TUNEL), content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) and for examination of the pathological changes which were scored.The apoptosis index (AI) was calculated. \u0000 \u0000 \u0000Results \u0000Compared with Sham group, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly increased, and the SOD activity in lung tissues was decreased in ALI group (P<0.05). Compared with ALI group, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly decreased, and the SOD activity in lung tissues was increased in ALI+ Dex and ALI+ Dex+ Y groups (P<0.05). Compared with group ALI+ Dex, the lung injury score, AI, levels of Fas, FasL, caspase-3 and MDA, and concentrations of TNF-α and IL-6 in serum were significantly increased, and the SOD activity in lung tissues was decreased in group ALI+ Dex+ Y (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Dexmedetomidine reduces ALI induced by \"double hit\" in rats, and the mechanism may be partially related to activating alpha-2 adrenergic receptor and inhibiting inflammatory responses, lipid peroxidation and cell apoptosis. \u0000 \u0000 \u0000Key words: \u0000Dexmedetomidine; Thoracic injury; Shock, hemorrhagic; Acute lung injury","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":"39 1","pages":"1379-1382"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42006521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.0254-1416.2019.11.021
Tao Li, Chen Gao, Xiao-qin Chai, S. Shu, Ling Zhou, Yanhu Xie
Objective To evaluate the effects of patient-controlled intravenous analgesia (PCIA) with nalbuphine on postoperative cellular immune function in the patients undergoing liver cancer resection. Methods Eighty hepatoma patients of both sexes, aged 40-64 yr, with body mass index 19-25 kg/m2, of American Society of Anesthesiologists physical status Ⅱ or Ⅲ, undergoing elective liver cancer resection, were divided into 2 groups (n=40 each) using a random number table method: sufentanil PCIA group (S group) and nalbuphine PCIA group (N group). Transverse abdominal plane block was performed in two groups.In group S, sufentanil 0.1 μg/kg was intravenously injected at 30 min before the end of surgery, PCIA was performed with sufentanil 2 μg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h.In group N, nalbuphine 0.1 mg/kg was intravenously injected at 30 min before the end of surgery, PCA was performed with nalbuphine 2 mg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCIA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h, maintaining visual analog scale score <4 within 48 h after surgery.Blood samples were collected from the right internal jugular vein on admission to operating room (T1) and 24 and 72 h after surgery (T2, 3) for measurement of levels of T lymphocyte subsets CD3+ , CD4+ and CD8+ , B cells and NK cells.CD4+ /CD8+ ratio was calculated. Results Compared with S group, levels of CD3+ and CD4+ cells at T2 and levels of CD4+ and NK cells at T3 were significantly increased in N group (P<0.05). Compared with the baseline at T1, the levels of CD3+ , CD4+ , NK and B cells at T2 and NK cells at T3 were significantly decreased in two groups, and CD4+ /CD8+ ratio was decreased at T2 in group S (P<0.05). Conclusion PCIA with nabuphine can improve the postoperative cellular immune function in the patients undergoing liver cancer resection. Key words: Nalbuphine; Analgesia, patient-controlled; Immunity, cellular
{"title":"Effects of PCIA with nalbuphine on postoperative cellular immune function in patients undergoing liver cancer resection","authors":"Tao Li, Chen Gao, Xiao-qin Chai, S. Shu, Ling Zhou, Yanhu Xie","doi":"10.3760/CMA.J.ISSN.0254-1416.2019.11.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2019.11.021","url":null,"abstract":"Objective \u0000To evaluate the effects of patient-controlled intravenous analgesia (PCIA) with nalbuphine on postoperative cellular immune function in the patients undergoing liver cancer resection. \u0000 \u0000 \u0000Methods \u0000Eighty hepatoma patients of both sexes, aged 40-64 yr, with body mass index 19-25 kg/m2, of American Society of Anesthesiologists physical status Ⅱ or Ⅲ, undergoing elective liver cancer resection, were divided into 2 groups (n=40 each) using a random number table method: sufentanil PCIA group (S group) and nalbuphine PCIA group (N group). Transverse abdominal plane block was performed in two groups.In group S, sufentanil 0.1 μg/kg was intravenously injected at 30 min before the end of surgery, PCIA was performed with sufentanil 2 μg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h.In group N, nalbuphine 0.1 mg/kg was intravenously injected at 30 min before the end of surgery, PCA was performed with nalbuphine 2 mg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCIA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h, maintaining visual analog scale score <4 within 48 h after surgery.Blood samples were collected from the right internal jugular vein on admission to operating room (T1) and 24 and 72 h after surgery (T2, 3) for measurement of levels of T lymphocyte subsets CD3+ , CD4+ and CD8+ , B cells and NK cells.CD4+ /CD8+ ratio was calculated. \u0000 \u0000 \u0000Results \u0000Compared with S group, levels of CD3+ and CD4+ cells at T2 and levels of CD4+ and NK cells at T3 were significantly increased in N group (P<0.05). Compared with the baseline at T1, the levels of CD3+ , CD4+ , NK and B cells at T2 and NK cells at T3 were significantly decreased in two groups, and CD4+ /CD8+ ratio was decreased at T2 in group S (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000PCIA with nabuphine can improve the postoperative cellular immune function in the patients undergoing liver cancer resection. \u0000 \u0000 \u0000Key words: \u0000Nalbuphine; Analgesia, patient-controlled; Immunity, cellular","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":"39 1","pages":"1357-1359"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48455802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.0254-1416.2019.11.004
Jianfeng Zhang, C. Xing, Ding-yi Wang, Xiaohong Chen, Yan Yu, Qian Yin, Huaiyue Diao, Ye Chen, Hanzhong Cao
Objective To evaluate the effect of chronic alcohol intake on postoperative analgesia in cancer patients. Methods American Society of Anesthesiologists physical status Ⅰ or Ⅱ male patients, aged ≥18 yr, underwent postoperative intelligentized patient-controlled analgesia management from January 1, 2016 to October 22, 2018, searched from wireless analgesia management system database, were selected.The patients were divided into control group and chronic alcoholic intake group according to the history of chronic alcoholic intake.Combined intravenous-inhalational anesthesia was used during surgery.Patient-controlled intravenous or subcutaneous analgesia was performed with sufentanil.When moderate pain occurred (4 points≤numeric rating scale score≤6 points), the parameters of analgesia pump was regulated for rescue analgesia.When severe pain occurred (numeric rating scale score at rest or during activity≥7 points), dezocine 0.5 mg was intravenously injected as rescue analgesic.The effective pressing times, the number of attempts, consumption of sufentanil and occurrence of moderate or severe pain were recorded.The adverse reactions such as nausea and vomiting, pruritus, dizziness and hypotension were also recorded. Results A total of 1 914 patients were enrolled in this study, with 1 508 cases in control group and 406 cases in chronic alcoholic intake group.Compared with control group, the effective pressing times, the number of attempts, consumption of sufentanil and incidence of moderate or severe pain were increased (P<0.05), and no significant change was found in the incidence of nausea and vomiting, pruritus, dizziness or hypotension in chronic alcoholic intake group (P<0.05). Conclusion Chronic alcohol intake can decrease the efficacy of postoperative analgesia in cancer patients. Key words: Alcohol drinking; Pain, postoperative; Analgesia, patient-controlled
{"title":"Effect of chronic alcohol intake on postoperative analgesia in cancer patients: a large sample, retrospective analysis","authors":"Jianfeng Zhang, C. Xing, Ding-yi Wang, Xiaohong Chen, Yan Yu, Qian Yin, Huaiyue Diao, Ye Chen, Hanzhong Cao","doi":"10.3760/CMA.J.ISSN.0254-1416.2019.11.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1416.2019.11.004","url":null,"abstract":"Objective \u0000To evaluate the effect of chronic alcohol intake on postoperative analgesia in cancer patients. \u0000 \u0000 \u0000Methods \u0000American Society of Anesthesiologists physical status Ⅰ or Ⅱ male patients, aged ≥18 yr, underwent postoperative intelligentized patient-controlled analgesia management from January 1, 2016 to October 22, 2018, searched from wireless analgesia management system database, were selected.The patients were divided into control group and chronic alcoholic intake group according to the history of chronic alcoholic intake.Combined intravenous-inhalational anesthesia was used during surgery.Patient-controlled intravenous or subcutaneous analgesia was performed with sufentanil.When moderate pain occurred (4 points≤numeric rating scale score≤6 points), the parameters of analgesia pump was regulated for rescue analgesia.When severe pain occurred (numeric rating scale score at rest or during activity≥7 points), dezocine 0.5 mg was intravenously injected as rescue analgesic.The effective pressing times, the number of attempts, consumption of sufentanil and occurrence of moderate or severe pain were recorded.The adverse reactions such as nausea and vomiting, pruritus, dizziness and hypotension were also recorded. \u0000 \u0000 \u0000Results \u0000A total of 1 914 patients were enrolled in this study, with 1 508 cases in control group and 406 cases in chronic alcoholic intake group.Compared with control group, the effective pressing times, the number of attempts, consumption of sufentanil and incidence of moderate or severe pain were increased (P<0.05), and no significant change was found in the incidence of nausea and vomiting, pruritus, dizziness or hypotension in chronic alcoholic intake group (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Chronic alcohol intake can decrease the efficacy of postoperative analgesia in cancer patients. \u0000 \u0000 \u0000Key words: \u0000Alcohol drinking; Pain, postoperative; Analgesia, patient-controlled","PeriodicalId":10053,"journal":{"name":"中华麻醉学杂志","volume":"39 1","pages":"1291-1293"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41852774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：