{"title":"Synthesis and Characterization of 2-Bromo-3-hydroxy-2-nitropropylcinnamate","authors":"","doi":"10.7598/cst2019.1705","DOIUrl":"https://doi.org/10.7598/cst2019.1705","url":null,"abstract":"","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80971377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-30DOI: 10.7598/cst2019.20190003
{"title":"Benzodioxole and 1,2,4-Oxadiazole Associated 1,2,3-Triazoles: Synthesis, Characterization and Evaluation as Antibacterial Agents","authors":"","doi":"10.7598/cst2019.20190003","DOIUrl":"https://doi.org/10.7598/cst2019.20190003","url":null,"abstract":"","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87941643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrochemical Behavior of Antidepressant Drug Vilazodone Hydrocholoride and its Determination at F-MWCNT-Nafion/GCE Sensor","authors":"","doi":"10.7598/cst2019.1596","DOIUrl":"https://doi.org/10.7598/cst2019.1596","url":null,"abstract":"","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75484387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-10DOI: 10.7598/cst2019.20190008
H. N. Deepakumari, M. Raghu, C. Kumar
: A novel class of hydantoin derivatives was synthesized and their antioxidant activity was evaluated. The newly synthesized compounds were characterized using 1 H NMR, IR, Mass spectra and elemental analysis. The antioxidant activity of synthesized compounds ( 3a-d ) were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide hydroxyl radical scavenging assay. It is revealed from the antioxidant screening results that the compounds 3a and 3d manifested profound antioxidant potential.
{"title":"Synthesis, Characterization and Antioxidant Activity of Novel 3-(2,5-dioxo-imidazolidin-1-yl)-1,1-diethylurea Derivatives","authors":"H. N. Deepakumari, M. Raghu, C. Kumar","doi":"10.7598/cst2019.20190008","DOIUrl":"https://doi.org/10.7598/cst2019.20190008","url":null,"abstract":": A novel class of hydantoin derivatives was synthesized and their antioxidant activity was evaluated. The newly synthesized compounds were characterized using 1 H NMR, IR, Mass spectra and elemental analysis. The antioxidant activity of synthesized compounds ( 3a-d ) were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide hydroxyl radical scavenging assay. It is revealed from the antioxidant screening results that the compounds 3a and 3d manifested profound antioxidant potential.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80429277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The volumetric behavior of binary mixtures of tetrahydrofuran (THF) +2-methoxyethanol (2-MeOEtOH), + 2-ethoxyethanol (2-EtOEtOH) and 2-butoxyethanol (2-BuOEtOH) were studied at 293.15, 298.15 and 303.15 K to identify the types and strengths of intermolecular interactions taking place in the solvent systems. The densities, ρ, of the pure solvents and the binary mixtures ranging from 0.0003-0.9997 of THF were obtained at the working temperatures. Excess molar volumes, V, of the binary mixtures were calculated from the density data. The calculated excess molar volumes were fitted into the Redlich-Kister polynomial and the fitting coefficients, Ai, obtained. The values of excess molar volumes were negative in all the solvent systems and at all temperatures in the mole fraction region of0.00-0.50 THF. Beyond the mole fraction region of 0.50, the excess molar volumes were slightly positive. The negative excess molar volumes in the region of low THF concentration are attributed to intermolecular hydrogen bonding between unlike molecules of THF and the alkoxyethanols. The magnitudes of the negative excess molar volumes were also found to be dependent upon the chain length of the alkoxy group and the temperature. The results show that the excess molar volumes become more negative when the chain length of the alkoxy group increased and this was attributed to the relative proton-donating ability of the alkoxyethanols investigated.
{"title":"Volumetric Behavior of Binary Mixtures of Tetrahydrofuran and C1-C4 Alkoxyethanols at Different Temperatures","authors":"Benjamin Amabibi Jumbo, A. Kemeakegha, C. Abasi","doi":"10.7598/cst2019.1588","DOIUrl":"https://doi.org/10.7598/cst2019.1588","url":null,"abstract":"The volumetric behavior of binary mixtures of tetrahydrofuran (THF) +2-methoxyethanol (2-MeOEtOH), + 2-ethoxyethanol (2-EtOEtOH) and 2-butoxyethanol (2-BuOEtOH) were studied at 293.15, 298.15 and 303.15 K to identify the types and strengths of intermolecular interactions taking place in the solvent systems. The densities, ρ, of the pure solvents and the binary mixtures ranging from 0.0003-0.9997 of THF were obtained at the working temperatures. Excess molar volumes, V, of the binary mixtures were calculated from the density data. The calculated excess molar volumes were fitted into the Redlich-Kister polynomial and the fitting coefficients, Ai, obtained. The values of excess molar volumes were negative in all the solvent systems and at all temperatures in the mole fraction region of0.00-0.50 THF. Beyond the mole fraction region of 0.50, the excess molar volumes were slightly positive. The negative excess molar volumes in the region of low THF concentration are attributed to intermolecular hydrogen bonding between unlike molecules of THF and the alkoxyethanols. The magnitudes of the negative excess molar volumes were also found to be dependent upon the chain length of the alkoxy group and the temperature. The results show that the excess molar volumes become more negative when the chain length of the alkoxy group increased and this was attributed to the relative proton-donating ability of the alkoxyethanols investigated.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89821461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charansing B. Ghoti, Swati V. Sonde, Keshav S. Kapgate, Ajit R. Kokare, Shivangi S. Apte, V. J. Thakre
: In India, Tigers, Leopards or any wild animals are inhibited in human dominated area to prevent harm to people as well as wild animals. If any wild animals enter in human dominated area, in such cases to save human beings from wild animals like Tigers, generally emergency immobilizations have to be carried with anesthetic drug i.e ., ketamine and xylazine. Usually their mixture is used for immobilization of wild animals. A rare case of Tigress with attempt of immobilization using dart of anesthetic drug was received first time in forensic science laboratory, Nagpur for simultaneous detection of ketamine and xylazine in biological and non biological samples. As per routine toxiclogical analysis of biological (Viscera, Muscle, Skin and blood) and non-biological (Dart with Needle) samples was performed by thin layer chromatography and confirmed by gas chromatography-mass spectroscopy (GCMS). The TLC and GC-MS examination revealed presence of anesthetic drug Ketamine and Xylazine in muscle piece, skin piece and dart with needle.
{"title":"Detection and Identification of Tranquilizer in Biological and Non-Biological Samples in Case of Tigress with History of Homicide","authors":"Charansing B. Ghoti, Swati V. Sonde, Keshav S. Kapgate, Ajit R. Kokare, Shivangi S. Apte, V. J. Thakre","doi":"10.7598/cst2019.1593","DOIUrl":"https://doi.org/10.7598/cst2019.1593","url":null,"abstract":": In India, Tigers, Leopards or any wild animals are inhibited in human dominated area to prevent harm to people as well as wild animals. If any wild animals enter in human dominated area, in such cases to save human beings from wild animals like Tigers, generally emergency immobilizations have to be carried with anesthetic drug i.e ., ketamine and xylazine. Usually their mixture is used for immobilization of wild animals. A rare case of Tigress with attempt of immobilization using dart of anesthetic drug was received first time in forensic science laboratory, Nagpur for simultaneous detection of ketamine and xylazine in biological and non biological samples. As per routine toxiclogical analysis of biological (Viscera, Muscle, Skin and blood) and non-biological (Dart with Needle) samples was performed by thin layer chromatography and confirmed by gas chromatography-mass spectroscopy (GCMS). The TLC and GC-MS examination revealed presence of anesthetic drug Ketamine and Xylazine in muscle piece, skin piece and dart with needle.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74496144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sharma, Mahadeva Singh Jat, K. K. Jhankal, D. K. Sharma
Electrochemical behaviour of cilnidipine at glassy carbon electrode was investigated using cyclic, square wave cathodic adsorptive stripping (SW-CAdS) and differential pulse cathodic adsorptive stripping (DP-CAdS) voltammetry under different experimental conditions. The voltammetric peak current and potential for the reduction of cilnidipine were analysed at different pH, scan rate and concentration. The voltammograms exhibited irreversible reduction of cilnidipine in B R buffer of pH 5.5. Cilnidipine gave one well-defined reduction peak at -0.821 potential versus Ag/AgCl reference electrode in BR buffer of pH 5.5. Reduction process was irreversible and diffusion controlled. Diffusion coefficients (7.45x10 cm/s and 6.45x10 cm/s), surface coverage (4.23x10mol/cm and 98.01x10mol/cm) and heterogeneous rate constant (1.25x10s) were calculated at bare GCE respectively. Based on CV, CPC and pH studies a reduction mechanism was proposed involving 6H/6e. The proposed square wave voltammetric method shows linearity over the concentration range (4.21x10-9.71x10 M) The achieved limits of detection (LOD) and quantification (LOQ) are 5.44x10 g/mL and 1.52x10g/mL respectively.
{"title":"Electrochemical Determination of Cardiovascular Drug Cilnidipine at Glassy Carbon Electrode in Pharmaceutical Formulations","authors":"R. Sharma, Mahadeva Singh Jat, K. K. Jhankal, D. K. Sharma","doi":"10.7598/cst2019.1597","DOIUrl":"https://doi.org/10.7598/cst2019.1597","url":null,"abstract":"Electrochemical behaviour of cilnidipine at glassy carbon electrode was investigated using cyclic, square wave cathodic adsorptive stripping (SW-CAdS) and differential pulse cathodic adsorptive stripping (DP-CAdS) voltammetry under different experimental conditions. The voltammetric peak current and potential for the reduction of cilnidipine were analysed at different pH, scan rate and concentration. The voltammograms exhibited irreversible reduction of cilnidipine in B R buffer of pH 5.5. Cilnidipine gave one well-defined reduction peak at -0.821 potential versus Ag/AgCl reference electrode in BR buffer of pH 5.5. Reduction process was irreversible and diffusion controlled. Diffusion coefficients (7.45x10 cm/s and 6.45x10 cm/s), surface coverage (4.23x10mol/cm and 98.01x10mol/cm) and heterogeneous rate constant (1.25x10s) were calculated at bare GCE respectively. Based on CV, CPC and pH studies a reduction mechanism was proposed involving 6H/6e. The proposed square wave voltammetric method shows linearity over the concentration range (4.21x10-9.71x10 M) The achieved limits of detection (LOD) and quantification (LOQ) are 5.44x10 g/mL and 1.52x10g/mL respectively.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88790250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preparation of one parent dioxomolybdenum(VI) complex of formula [MoO2(L)](acac)2 with a Schiff base, obtained from condensation of thenil with 2,3-diamino-5-chloropyridine and four new complexes having formula [MoO2(ML)](acac)2, derived from cyclization of [MoO2(L)](acac)2 with β-diketones are reported in this research paper. The prepared five dioxomolybdenum(VI) complexes have been described by elemental analyses, molar conductance, UV-Vis, IR, NMR and thermal studies. The feasibility of coordination number of molybdenum metal is six. All five complexes of dioxomolybdenum(VI) have octahedral geometry. The octahedral coordination circle of molybdenum in synthesized dioxomolybdenum complexes is completed by two oxo oxygen atoms and four nitrogen atoms from derived ligand. The shape of synthesized dioxomolybdenum(VI) complexes have distorted octahedral. All the synthesized complexes showed moderate activity against S. aureus and S. typhi, the improvement in the antibacterial activity being explained on the basis of chelation hypothesis.
{"title":"New Insights into the Chemistry of cis-Dioxomolybdenum(VI) Schiff Base Complexes with Macrocyclic Ligands","authors":"R. K. Gautam, C. Singh, D. Kumar, D. P. Rao","doi":"10.7598/cst2019.1594","DOIUrl":"https://doi.org/10.7598/cst2019.1594","url":null,"abstract":"Preparation of one parent dioxomolybdenum(VI) complex of formula [MoO2(L)](acac)2 with a Schiff base, obtained from condensation of thenil with 2,3-diamino-5-chloropyridine and four new complexes having formula [MoO2(ML)](acac)2, derived from cyclization of [MoO2(L)](acac)2 with β-diketones are reported in this research paper. The prepared five dioxomolybdenum(VI) complexes have been described by elemental analyses, molar conductance, UV-Vis, IR, NMR and thermal studies. The feasibility of coordination number of molybdenum metal is six. All five complexes of dioxomolybdenum(VI) have octahedral geometry. The octahedral coordination circle of molybdenum in synthesized dioxomolybdenum complexes is completed by two oxo oxygen atoms and four nitrogen atoms from derived ligand. The shape of synthesized dioxomolybdenum(VI) complexes have distorted octahedral. All the synthesized complexes showed moderate activity against S. aureus and S. typhi, the improvement in the antibacterial activity being explained on the basis of chelation hypothesis.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84063818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Drugs have been used for the treatment of infectious diseases since the 17 th century. However, chemotherapy as a science began in the first decade of the 20 th century with understanding of the principles of selective toxicity, the specific chemical relationships between microbial pathogens and drugs, the development of drug resistance and the role of combined therapy. Analysis of such drugs, whether used for treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety. Thus, this review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for cefquinome, a fourth generation cephalosporine used to treat infections caused by gram-positive and gram-negative microorganisms.
{"title":"Characteristics, Properties and Analytical Methods of Cefquinome - A Review","authors":"S. Shantier","doi":"10.7598/cst2019.1488","DOIUrl":"https://doi.org/10.7598/cst2019.1488","url":null,"abstract":": Drugs have been used for the treatment of infectious diseases since the 17 th century. However, chemotherapy as a science began in the first decade of the 20 th century with understanding of the principles of selective toxicity, the specific chemical relationships between microbial pathogens and drugs, the development of drug resistance and the role of combined therapy. Analysis of such drugs, whether used for treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety. Thus, this review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for cefquinome, a fourth generation cephalosporine used to treat infections caused by gram-positive and gram-negative microorganisms.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74677763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Jagannadham, Dodda Vivekananda Reddy, B. Ramadevi, B. Prasanna
Over the past decade, design of 2-azetidinones scaffold has attracted greater interest of synthesis because of more biological and pharmacological potencies. Specifically, sulfonamide rings and their derivatives represent a medicinally and pharmaceutically important class of heterocyclic motifs that are found as the core structural skeletons in a variety of several naturally occurring alkaloids. We effectively intended 4-(3-chloro-2-oxo-4-aryllazetidin-1-yl)-2-(1-(3-ethoxy-4methoxyphenyl)-2-(methylsulfonyl)-ethyl)-2,4′-biisoindoline-1.1′3,3′-tetraones (6(a-f)). 4-Amino-2′(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,4′-biisoindo line-1, 1′, 3, 3′-tetraone 3 was prepared by condensation of 3-aminophthalic acid 2 with 1,3-ethoxy-4-methoxyphenyl)-2methylsutfonylethylamine 1 by a single step. Condensation of compound 3 with various aromatic aldehydes gives substituted Schiff base of 2′-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)2,4′-biisoindoline-1,1′,3,3′-tetraones (5(a-f)) which upon dehydrative annulation in the presence of chloroacetylchloride in the presence of triethylamine in DCM solvent yielded 4-(3-Chloro-2-oxo-4aryllazetidin-1-yl)-2′-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethyl)-2,4′-biisoindoline1.1′3,3′-tetraones 6(a-f). All the synthesized compounds were recognized by Infra Red-Vibrational spectroscopy, Proton Nuclear Magnetic Resonance, mass spectroscopy and their C, H, N analyses.
{"title":"Synthesis of Substituted Azetidinones Derived from Dimer of Apremilast","authors":"Y. Jagannadham, Dodda Vivekananda Reddy, B. Ramadevi, B. Prasanna","doi":"10.7598/cst2019.1579","DOIUrl":"https://doi.org/10.7598/cst2019.1579","url":null,"abstract":"Over the past decade, design of 2-azetidinones scaffold has attracted greater interest of synthesis because of more biological and pharmacological potencies. Specifically, sulfonamide rings and their derivatives represent a medicinally and pharmaceutically important class of heterocyclic motifs that are found as the core structural skeletons in a variety of several naturally occurring alkaloids. We effectively intended 4-(3-chloro-2-oxo-4-aryllazetidin-1-yl)-2-(1-(3-ethoxy-4methoxyphenyl)-2-(methylsulfonyl)-ethyl)-2,4′-biisoindoline-1.1′3,3′-tetraones (6(a-f)). 4-Amino-2′(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,4′-biisoindo line-1, 1′, 3, 3′-tetraone 3 was prepared by condensation of 3-aminophthalic acid 2 with 1,3-ethoxy-4-methoxyphenyl)-2methylsutfonylethylamine 1 by a single step. Condensation of compound 3 with various aromatic aldehydes gives substituted Schiff base of 2′-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)2,4′-biisoindoline-1,1′,3,3′-tetraones (5(a-f)) which upon dehydrative annulation in the presence of chloroacetylchloride in the presence of triethylamine in DCM solvent yielded 4-(3-Chloro-2-oxo-4aryllazetidin-1-yl)-2′-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethyl)-2,4′-biisoindoline1.1′3,3′-tetraones 6(a-f). All the synthesized compounds were recognized by Infra Red-Vibrational spectroscopy, Proton Nuclear Magnetic Resonance, mass spectroscopy and their C, H, N analyses.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90448781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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