Obesity Pillars最新文献_第9页

Leveraging the construct of physical literacy to promote physical activity for youth with obesity – A qualitative analysis of physical therapists’ perceptions 利用身体素养的建构促进肥胖青少年的身体活动——对物理治疗师看法的定性分析

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2022.100054

Matthew K. Paponetti , Christin Zwolski , Rose Porter , Mark V. Paterno

Background

Promoting physical activity has been identified as a pillar of obesity treatment and prevention. However, youth with obesity often present with physical, affective, and environmental barriers to physical activity engagement. The construct of physical literacy, which has garnered international attention as a holistic approach to understanding human movement, may improve physical activity promotion strategies for youth with obesity. However, literature has shown that healthcare providers are not engaged with the construct of physical literacy.

Methods

This qualitative study utilized a phenomenological approach and interpretivist epistemology. Three phases of data collection included member checks, semi-structured interviews, and a focus group with physical therapists treating youth with orthopedic and sport injuries. Simultaneous data collection and inductive analysis was designed to identify themes reflecting how participants utilized the construct of physical literacy to promote physical activity in a clinical setting.

Results

Four overarching themes were identified in our analysis as strategies for promoting activity and physical literacy development: 1) Movement Experience, 2) Individualized Care, 3) Movement Momentum, and 4) External Factors.

Conclusion

The findings from this study highlight the usefulness of applying a physical literacy lens within physical activity promotion efforts among youth, which may be particularly important for youth with obesity. A high value was placed on the affective and behavioral determinants of physical activity. By applying a physical literacy lens, healthcare providers treating youth with obesity may be better equipped to address barriers and promote participation in physical activities that are enjoyable and build confidence. The findings from this study provide a foundation for future studies examining how healthcare providers can leverage the construct of physical literacy to improve physical activity outcomes among youth.

背景促进体育活动已被确定为肥胖治疗和预防的支柱。然而，肥胖青年在参与体育活动方面往往存在身体、情感和环境障碍。体育素养作为理解人类运动的一种整体方法，已引起国际关注，它可能会改善肥胖青年的体育活动促进策略。然而，文献表明，医疗保健提供者没有参与身体识字的构建。方法运用现象学方法和解释主义认识论进行定性研究。数据收集的三个阶段包括成员检查、半结构化访谈，以及由物理治疗师组成的焦点小组，治疗骨科和运动损伤的年轻人。同时进行数据收集和归纳分析，以确定反映参与者如何利用身体识字结构在临床环境中促进身体活动的主题。结果在我们的分析中，四个总体主题被确定为促进活动和体育素养发展的策略：1）运动体验，2）个性化护理，3）运动动力，以及4）外部因素，这对于患有肥胖症的年轻人来说可能特别重要。人们高度重视体育活动的情感和行为决定因素。通过应用体育素养的视角，治疗肥胖青年的医疗保健提供者可能会更好地解决障碍，促进参与令人愉快的体育活动并建立信心。这项研究的发现为未来的研究奠定了基础，研究医疗保健提供者如何利用体育素养的结构来改善青少年的体育活动结果。

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引用次数: 5

Obesity, overweight and hyperglycemia among primary school children in a low-middle income country with a multiethnic population 一个多民族低收入国家小学生的肥胖、超重和高血糖

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2022.100053

Jerry R. Toelsie , Frederika Morpurgo , Ingrid Krishnadath , Robbert Bipat

Objective

The number of children with cardiovascular risk factors is increasing steadily. However, limited data are available on the prevalence of overweight, obesity, and hyperglycemia among children in low-middle-income countries with multiethnic populations. Therefore, we assessed these factors in a school-based survey in Suriname, a low-middle-income country.

Methods

We invited pupils of 5^th and 6^th grade visiting the primary school to participate in this survey. We used a questionnaire and face to face interviews, and conducted measurements to collect data on biological factors (ethnicity, sex, length, weight, waist circumference, and fasting blood glucose levels), behavior (frequency of physical activity, breakfast, bedtime, screentime), consumption (fruit and vegetables, snack, dairy products) and social factors (parental education, living area).

Results

Overall, the percentage of children with overweight was 13.9%, obesity 13.3% and for elevated fasting blood glucose level (> 6 mmol/L) 4.5%. In the investigated group of individuals, obesity and overweight were associated with sex (girls showed a lower OR of 0.54 [95%CI: 0.39–0.75] for obesity), ethnicity (Javanese 2.1, 1.5–3.0 for overweight and 5.0, 3.1–8.2 for obesity, Maroon 2.2, 1.2–4.1 and Mixed ethnicity 1.7, 1.1–2.6, for obesity compared to Hindustani), behavior (Skip Breakfast: 1.4, 1.2–1.7, physical activity: 0.8, 0.7–0.9) and maternal education level (high 1.7, 1.0–2.7). Children with elevated fasting blood glucose levels showed an association with obesity (1.8, 1.2–2.7) and waist circumference (1.02, 1.01–1.03).

Conclusion

The results show that there is a high prevalence for overweight, obesity and elevated fasting blood glucose among children in Suriname. Furthermore, during childhood ethnicity is associated with obesity and overweight. We suggest that the modifiable risk factors such as BMI, WC, behavior, consumption are interesting for early intervention in children in a developing country.

目的有心血管危险因素的儿童数量正在稳步增加。然而，关于多民族人口的中低收入国家儿童超重、肥胖和高血糖患病率的数据有限。因此，我们在苏里南这个中低收入国家的一项基于学校的调查中评估了这些因素。方法邀请小学五年级和六年级的学生参加本次调查。我们使用问卷调查和面对面访谈，并进行测量以收集生物学因素（种族、性别、身高、体重、腰围和空腹血糖水平）、行为（体育活动频率、早餐、就寝时间、放映时间）、，结果总体而言，超重儿童比例为13.9%，肥胖儿童比例为13.3%，空腹血糖水平升高（>；6mmol/L）儿童比例为4.5%，肥胖和超重与性别（女孩肥胖的OR较低，为0.54[95%CI:0.39-0.75]）、种族（与印度斯坦人相比，爪哇人超重的OR为2.1，1.5-3.0，肥胖的OR为5.0，3.1-8.2，马龙人肥胖的OR分别为2.2，1.2-4.1和混合种族的OR为1.7，1.1-2.6）、，行为（不吃早餐：1.4，1.2–1.7，体育活动：0.8，0.7–0.9）和母亲教育水平（高1.7，1.0–2.7）。空腹血糖水平升高的儿童与肥胖（1.8，1.2–2.7）和腰围（1.02，1.01–1.03）有关，苏里南儿童肥胖和空腹血糖升高。此外，在儿童时期，种族与肥胖和超重有关。我们认为，BMI、WC、行为、消费等可改变的风险因素对发展中国家儿童的早期干预很有意义。

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引用次数: 0

Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023 肥胖、糖尿病和心脏代谢风险:肥胖医学协会(OMA)临床实践声明(CPS) 2023

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2023.100056

Harold Edward Bays , Shagun Bindlish , Tiffany Lowe Clayton

Background

This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) is intended to provide clinicians an overview of type 2 diabetes mellitus (T2DM), an obesity-related cardiometabolic risk factor.

Methods

The scientific support for this CPS is based upon published citations and clinical perspectives of OMA authors.

Results

Topics include T2DM and obesity as cardiometabolic risk factors, definitions of obesity and adiposopathy, and mechanisms for how obesity causes insulin resistance and beta cell dysfunction. Adipose tissue is an active immune and endocrine organ, whose adiposopathic obesity-mediated dysfunction contributes to metabolic abnormalities often encountered in clinical practice, including hyperglycemia (e.g., pre-diabetes mellitus and T2DM). The determination as to whether adiposopathy ultimately leads to clinical metabolic disease depends on crosstalk interactions and biometabolic responses of non-adipose tissue organs such as liver, muscle, pancreas, kidney, and brain.

Conclusions

This review is intended to assist clinicians in the care of patients with the disease of obesity and T2DM. This CPS provides a simplified overview of how obesity may cause insulin resistance, pre-diabetes, and T2DM. It also provides an algorithmic approach towards treatment of a patient with obesity and T2DM, with “treat obesity first” as a priority. Finally, treatment of obesity and T2DM might best focus upon therapies that not only improve the weight of patients, but also improve the health outcomes of patients (e.g., cardiovascular disease and cancer).

背景本肥胖医学协会（OMA）临床实践声明（CPS）旨在为临床医生提供2型糖尿病（T2DM）的概述，这是一种与肥胖相关的心脏代谢风险因素。方法对该CPS的科学支持是基于OMA作者发表的引文和临床观点。结果主题包括T2DM和肥胖作为心脏代谢危险因素，肥胖和脂肪病的定义，以及肥胖如何导致胰岛素抵抗和β细胞功能障碍的机制。脂肪组织是一种活跃的免疫和内分泌器官，其脂肪性肥胖介导的功能障碍会导致临床实践中经常遇到的代谢异常，包括高血糖（如糖尿病前期和T2DM）。脂肪病是否最终导致临床代谢疾病的确定取决于非脂肪组织器官（如肝脏、肌肉、胰腺、肾脏和大脑）的串扰相互作用和生物代谢反应。结论本综述旨在协助临床医生对肥胖和T2DM患者的护理。本CPS提供了肥胖如何导致胰岛素抵抗、糖尿病前期和T2DM的简化概述。它还提供了一种治疗肥胖和T2DM患者的算法方法，将“首先治疗肥胖”作为优先事项。最后，肥胖和T2DM的治疗可能最好集中在不仅能改善患者体重，还能改善患者健康结果（如心血管疾病和癌症）的治疗上。

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引用次数: 10

Case report of PLXNA4 variant associated with hyper-response to phentermine/topiramate pharmacotherapy: Potential genetic basis for superior weight loss response? PLXNA4变异与芬特明/托吡酯药物治疗超反应相关的病例报告:优越减肥反应的潜在遗传基础?

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2023.100059

Maria Paszkowiak , Madisen Fae Dorand , Jesse Richards

Background

Once thought to be primarily a result of lifestyle, it is now known that obesity has significant genetic components. Dozens of genes have been linked to obesity, and office-based genetic testing for obesity-associated genes is now readily available. As both pharmacotherapy and genetic testing for obesity become more accessible, pharmacogenetic personalization is becoming a reality. In this case report, a patient with a PLXNA4 polymorphism had a superior weight loss response to phentermine/topiramate therapy than has previously been reported in the literature. Thus, variants in PLXNA4 may provide a genetic basis for this patient's superior response to weight loss pharmacotherapy and cardiovascular risk factor reduction.

Methods

In this case study, office-based genetic testing was utilized to identify the presence of variants in nearly 80 genes that have been linked to obesity in a patient who had hyper-responsive weight loss results on phentermine/topiramate pharmacotherapy.

Results

A variant of the PLXNA4 gene, which has known pathogenic variants linked to genetic obesity syndromes, was identified in this patient who had a superior weight loss response to phentermine/topiramate pharmacotherapy.

Conclusion

Due to overlapping molecular pathways, it is possible that PLXNA4 variants convey a superior weight-loss response and therefore superior cardiovascular risk factor reduction phentermine/topiramate therapy. Further studies are needed to examine the relationship between PLXNA4 variants and weight loss with phentermine/topiramate pharmacotherapy.

背景肥胖曾经被认为主要是生活方式的结果，现在已经知道它有重要的遗传成分。数十种基因与肥胖有关，基于办公室的肥胖相关基因检测现在很容易获得。随着肥胖的药物治疗和基因检测变得越来越容易，药物遗传学个性化正在成为现实。在本病例报告中，一名PLXNA4多态性患者对苯妥明/托吡酯治疗的减肥反应比文献中报道的要好。因此，PLXNA4的变体可能为该患者对减肥药物治疗和心血管风险因素降低的卓越反应提供遗传基础。方法在本案例研究中，使用基于办公室的基因检测来确定一名患者近80个与肥胖有关的基因中是否存在变异，该患者对苯妥明/托吡酯药物治疗的减肥结果具有高度反应性。结果在该患者中发现了PLXNA4基因的一个变体，该变体具有与遗传性肥胖综合征相关的已知致病性变体，该患者对苯妥明/托吡酯药物治疗具有良好的减肥反应。结论由于分子途径重叠，PLXNA4变体可能传达出优越的减肥反应，从而传递出优越的心血管危险因素降低芬妥明/托吡酯治疗。需要进一步的研究来检验PLXNA4变体与苯妥明/托吡酯药物治疗减肥之间的关系。

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引用次数: 0

Association of normal weight obesity with lifestyle and dietary habits in young Thai women: A cross-sectional study 泰国年轻女性正常体重肥胖与生活方式和饮食习惯的关系:一项横断面研究

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2023.100055

Minatsu Kobayashi , Paponpat Pattarathitwat , Apidech Pongprajakand , Sikaret Kongkaew

Background

The risk of lifestyle-related diseases in normal weight obesity (NWO), a condition, in which the body mass index (BMI) is normal but the body fat mass is high, has attracted a lot of attention. However, there are no reports on the association between NWO and lifestyle, eating habits, and other health risks in Thai people. BMI alone cannot be used to identify individuals with NWO; thus, some students with NWO develop metabolic abnormalities without receiving any intervention. This study aimed to examine the differences in anthropometrics, lifestyle, and eating habits among young Thai women and their association with the BMI and the body fat ratio (BFR).

Methods

A total of 250 female Thai university students of normal body type (18.5 ≤ BMI<25.0 kg/m²) were classified as having non-normal weight obesity (NO-NWO) if their BFR was <30.0% or NWO if their BMI and BFR were >30.0%. The lifestyle and eating habits of the two groups were compared. We conducted logistic analysis with the presence or absence of NWO as the dependent variable, and the dietary habit items of “eating greasy foods,” “eating ultra-processed foods (UPF),” and “drinking sweetened beverages” as the objective variables.

Results

Among the study participants who were of normal body type, 46.8% were NWO. The participants in the NWO group consumed UPF more frequently (odds ratio [OR], 2.04; p = 0.014) and sweetened beverages more regularly (OR, 1.92, p = 0.041) than those in the NO-NWO group.

Conclusion

UPF and sweetened beverage consumption was more common in individuals with NWO. Identifying the risk factors for NWO is essential to help individuals make lifestyle changes to prevent its progression and complications.

背景正常体重肥胖（NWO）是一种身体质量指数（BMI）正常但体脂量高的疾病，其生活方式相关疾病的风险已引起人们的广泛关注。然而，目前还没有关于NWO与泰国人的生活方式、饮食习惯和其他健康风险之间的联系的报告。BMI不能单独用于识别NWO患者；因此，一些患有NWO的学生在没有接受任何干预的情况下出现代谢异常。本研究旨在探讨泰国年轻女性在人体测量、生活方式和饮食习惯方面的差异及其与BMI和体脂比（BFR）的关系；30.0%或NWO，如果它们的BMI和BFR为>；比较两组患者的生活方式和饮食习惯。我们以是否存在NWO为因变量，以“吃油腻食物”、“吃超加工食品（UPF）”和“喝加糖饮料”等饮食习惯项目为客观变量进行了逻辑分析。结果在正常体型的受试者中，NWO占46.8%。与NO-NWO组相比，NWO组的参与者更频繁地摄入UPF（比值比[OR]，2.04；p=0.014），更经常地摄入加糖饮料（比值比，1.92，p=0.041）。结论UPF和加糖饮料在NWO患者中更常见。识别NWO的风险因素对于帮助个人改变生活方式以防止其进展和并发症至关重要。

{"title":"Association of normal weight obesity with lifestyle and dietary habits in young Thai women: A cross-sectional study","authors":"Minatsu Kobayashi , Paponpat Pattarathitwat , Apidech Pongprajakand , Sikaret Kongkaew","doi":"10.1016/j.obpill.2023.100055","DOIUrl":"https://doi.org/10.1016/j.obpill.2023.100055","url":null,"abstract":"<div><h3>Background</h3><p>The risk of lifestyle-related diseases in normal weight obesity (NWO), a condition, in which the body mass index (BMI) is normal but the body fat mass is high, has attracted a lot of attention. However, there are no reports on the association between NWO and lifestyle, eating habits, and other health risks in Thai people. BMI alone cannot be used to identify individuals with NWO; thus, some students with NWO develop metabolic abnormalities without receiving any intervention. This study aimed to examine the differences in anthropometrics, lifestyle, and eating habits among young Thai women and their association with the BMI and the body fat ratio (BFR).</p></div><div><h3>Methods</h3><p>A total of 250 female Thai university students of normal body type (18.5 ≤ BMI<25.0 kg/m<sup>2</sup>) were classified as having non-normal weight obesity (NO-NWO) if their BFR was <30.0% or NWO if their BMI and BFR were >30.0%. The lifestyle and eating habits of the two groups were compared. We conducted logistic analysis with the presence or absence of NWO as the dependent variable, and the dietary habit items of “eating greasy foods,” “eating ultra-processed foods (UPF),” and “drinking sweetened beverages” as the objective variables.</p></div><div><h3>Results</h3><p>Among the study participants who were of normal body type, 46.8% were NWO. The participants in the NWO group consumed UPF more frequently (odds ratio [OR], 2.04; p = 0.014) and sweetened beverages more regularly (OR, 1.92, p = 0.041) than those in the NO-NWO group.</p></div><div><h3>Conclusion</h3><p>UPF and sweetened beverage consumption was more common in individuals with NWO. Identifying the risk factors for NWO is essential to help individuals make lifestyle changes to prevent its progression and complications.</p></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49730056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Motivational and self-regulatory processes associated with weight-related parenting behaviors 与体重相关的育儿行为相关的动机和自我调节过程

Obesity Pillars

Pub Date : 2023-03-01 DOI: 10.1016/j.obpill.2022.100049

Bridgette Do , Nanette V. Lopez , Genevieve F. Dunton , Tyler B. Mason

Background

Parents play an influential role on their child’s eating and physical activity. How maternal personality and individual differences, such as motivation and self-regulation, are associated with their weight-related parenting has yet to be studied. The current study examined relationships of mothers’ motivational and self-regulatory characteristics with weight-related parenting practices.

Methods

Mothers (N = 149, M_Age = 42.78 years, 49% Hispanic/Latino) of school-aged children (ages 10-14 years, 55.7% female) completed questionnaires assessing behavioral inhibition system/behavioral activation system (BIS/BAS), self-control, and weight-related parenting practices (i.e., role modeling, food restriction, rule enforcement, limiting, discipline, pressure to eat). Structural equation modeling examined associations of BIS, BAS, and self-control with parenting practices.

Results

Among mothers, higher avoidance motivation was associated with difficulty with rule enforcement. Higher approach motivation was associated with less limiting of unhealthy food and sedentary behavior. Higher self-control predicted more role modeling and less difficulty with rule enforcement.

Conclusion

Findings support associations of maternal motivational and self-regulatory processes with weight-related parenting behaviors. Results may inform tailored strategies based on individual differences for family-based interventions for parenting.

背景父母在孩子的饮食和体育活动中发挥着重要作用。母亲的个性和个体差异，如动机和自我调节，如何与体重相关的育儿方式相关，还有待研究。目前的研究调查了母亲的动机和自我调节特征与体重相关的育儿实践之间的关系。方法学龄儿童（10-14岁，55.7%女性）的母亲（N=149，MAge=42.78岁，49%为西班牙裔/拉丁裔）完成问卷调查，评估行为抑制系统/行为激活系统（BIS/BAS）、自我控制和与体重相关的育儿实践（即角色塑造、食物限制、规则执行、限制、纪律、饮食压力）。结构方程模型检验了BIS、BAS和自我控制与育儿实践的关系。结果在母亲中，较高的回避动机与规则执行困难有关。接近动机越高，对不健康食物和久坐行为的限制越少。更高的自制力预示着更多的角色建模和更少的规则执行难度。结论研究结果支持母亲的动机和自我调节过程与体重相关的养育行为之间的联系。研究结果可能会为基于个体差异的个性化策略提供信息，用于基于家庭的育儿干预。

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引用次数: 0

Corrigendum to “Social consequences and genetics for the child with overweight and obesity: An obesity medicine association (OMA) clinical practice statement 2022” [Obes. Pillars 3 (2022) 100032] “超重和肥胖儿童的社会后果和遗传学:肥胖医学协会(OMA)临床实践声明2022”的勘误表[Obes]。支柱3 (2022)100032]

Obesity Pillars

Pub Date : 2022-12-01 DOI: 10.1016/j.obpill.2022.100037

Suzanne Cuda , Marisa Censani , Roohi Kharofa , Dominique R. Williams , Valerie O'Hara , Sara Karjoo , Jennifer Paisley , Nancy T. Browne

引用次数: 0

Stress, psychiatric disease, and obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022 压力，精神疾病和肥胖:肥胖医学协会(OMA)临床实践声明(CPS) 2022

Obesity Pillars

Pub Date : 2022-12-01 DOI: 10.1016/j.obpill.2022.100041

Sandra M. Christensen , Catherine Varney , Vivek Gupta , Lori Wenz , Harold Edward Bays

Background

Previous Obesity Medicine Association (OMA) Clinical Practice Statements (CPS) included topics such as behavior modification, motivational interviewing, and eating disorders, as well as the effect of concomitant medications on weight gain/reduction (i.e., including psychiatric medications). This OMA CPS provides clinicians a more focused overview of stress and psychiatric disease as they relate to obesity.

Methods

The scientific support for this CPS is based upon published citations, clinical perspectives of OMA authors, and peer review by the Obesity Medicine Association leadership.

Results

Topics in this CPS include the relationship between psychological stress and obesity, including both acute and chronic stress. Additionally, this CPS describes the neurobiological pathways regarding stress and addiction-like eating behavior and explores the relationship between psychiatric disease and obesity, with an overview of psychiatric medications and their potential effects on weight gain and weight reduction.

Conclusions

This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) on stress and psychiatric disease is one of a series of OMA CPSs designed to assist clinicians in the care of patients with the disease of obesity. Knowledge of stress, addiction-like eating behavior, psychiatric disease, and effects of psychiatric medications on body weight may improve the care obesity medicine clinicians provide to their patients with obesity.

以前的肥胖医学协会(OMA)临床实践声明(CPS)包括行为改变、动机访谈、饮食失调以及伴随药物对体重增加/减少的影响(即，包括精神药物)等主题。本OMA CPS为临床医生提供了与肥胖相关的压力和精神疾病的更集中的概述。方法:本CPS的科学支持基于已发表的引用、OMA作者的临床观点以及肥胖医学协会领导层的同行评审。结果研究对象包括心理应激与肥胖的关系，包括急性和慢性应激。此外，本CPS描述了有关压力和成瘾样饮食行为的神经生物学途径，并探讨了精神疾病和肥胖之间的关系，概述了精神药物及其对体重增加和减轻的潜在影响。结论肥胖医学协会(OMA)关于压力与精神疾病的临床实践声明(CPS)是OMA旨在帮助临床医生护理肥胖患者的一系列临床实践声明之一。对压力、成瘾性饮食行为、精神疾病以及精神药物对体重的影响的了解，可能会改善临床医生对肥胖患者的护理。

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引用次数: 6

Corrigendum to “Nutritional and activity recommendations for the child with normal weight, overweight, and obesity with consideration of food insecurity: An Obesity Medical Association (OMA) Clinical Practice Statement 2022” [Obesity Pillars 2 (2022) 100012] “考虑到食物不安全，对正常体重、超重和肥胖儿童的营养和活动建议:肥胖医学协会(OMA)临床实践声明2022”[肥胖支柱2(2022)100012]的更正

Obesity Pillars

Pub Date : 2022-12-01 DOI: 10.1016/j.obpill.2022.100036

Nancy T. Browne , Suzanne E. Cuda

引用次数: 0

Decreased cardiovascular risk factors and inflammation with remission of type 2 diabetes in adults with obesity using a high protein diet: Randomized control trial 高蛋白饮食降低心血管危险因素和2型糖尿病缓解的成人肥胖患者的炎症:随机对照试验

Obesity Pillars

Pub Date : 2022-12-01 DOI: 10.1016/j.obpill.2022.100047

Frankie B. Stentz, Damon Lawson, Sidney Tucker, John Christman, Chris Sands

Objective

The study objective was to determine the effects a high protein (HP) vs. a high carbohydrate (HC) diet on cardiovascular risk factors (CVR), inflammation, metabolic parameters, oxidative stress, weight loss, lean and fat body mass, and remission of Type 2 Diabetes (T2DM) in subjects with obesity.

Research design and methods

Twelve women and men with T2D were recruited and randomized to either a HP (30%protein, 30%fat, 40%carbohydrate) (n = 6) or HC (15%protein, 30%fat, 55%carbohydrate) (n = 6) diet feeding study for 6 months in this randomized controlled trial. All meals were purchased at local grocery stores and provided to subjects for 6 months with daily food menus for HP or HC compliance with weekly food pick-up and weight measurements. Oral glucose tolerance and meal tolerance tests with glucose and insulin measurements and DXA scans were done at baseline and after 6 months on the respective diets.

Results

After 6 months on the HP diet, 100% of the subjects had remission of their T2DM to Normal Glucose Tolerance (NGT), whereas only 16.6% of subjects on the HC diet had remission of their T2DM. The HP diet group exhibited significant improvement in a) cardiovascular risk factors (p = 0.004, b) inflammatory cytokines(p = 0.001), c) insulin sensitivity(p = 0.001), d) oxidative stress(p = 0.001), e) increased %lean body mass(p = 0.001) compared to the HC diet group at 6 months.

Conclusions

A significant improvement in cardiovascular risk factors, inflammation, metabolic parameters and 100% remission of T2DM to NGT was achieved with a HP diet compared to a HC diet at 6 months.

Clinicaltrials.gov. identifier

NCT01642849.

研究目的是确定高蛋白(HP)与高碳水化合物(HC)饮食对肥胖受试者心血管危险因素(CVR)、炎症、代谢参数、氧化应激、体重减轻、瘦体重和胖体重以及2型糖尿病(T2DM)缓解的影响。研究设计与方法本随机对照试验招募12名T2D患者，随机分为HP(30%蛋白质、30%脂肪、40%碳水化合物)(n = 6)或HC(15%蛋白质、30%脂肪、55%碳水化合物)(n = 6)组，为期6个月。所有膳食均在当地杂货店购买，并提供给受试者6个月的每日食物菜单，以检查HP或HC是否符合每周取餐和体重测量。口服葡萄糖耐量和膳食耐量试验，包括葡萄糖和胰岛素测量以及DXA扫描，分别在基线和各自饮食6个月后进行。结果在HP饮食6个月后，100%的受试者T2DM缓解到正常葡萄糖耐量(NGT)，而HC饮食组只有16.6%的受试者T2DM缓解。6个月时，与HC饮食组相比，HP饮食组在a)心血管危险因素(p = 0.004, b)炎症因子(p = 0.001)， c)胰岛素敏感性(p = 0.001)， d)氧化应激(p = 0.001)， e)瘦体重增加(p = 0.001)方面表现出显著改善。结论在6个月时，与HC饮食相比，HP饮食在心血管危险因素、炎症、代谢参数和T2DM到NGT的100%缓解方面均有显著改善。identifierNCT01642849。

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引用次数: 0