Obesity Pillars最新文献_第8页

Patient perceptions about obesity management in the context of concomitant care for other chronic diseases 在其他慢性疾病的伴随治疗的背景下，患者对肥胖管理的看法

Obesity Pillars

Pub Date : 2023-09-24 DOI: 10.1016/j.obpill.2023.100089

Ian Patton , Ximena Ramos Salas , Brad Hussey , Megha Poddar , Sanjeev Sockalingam , Laurie Twells , Hassan Mir , Mary Forhan , Pam Hung , Al Martin , Lisa Schaffer , Candace Vilhan

Background

Approximately 15% of Canadian adults live with two or more chronic diseases, many of which are obesity related. The degree to which Canadian obesity treatment guidelines are integrated into chronic disease management is unknown.

Methods

We conducted a 12-min online survey among a non-probability sample of 2506 adult Canadians who met at least one of the following criteria: 1) BMI ≥30 kg/m²; 2) medical diagnosis of obesity; 3) undergone medically supervised treatment for obesity; or 4) a belief that excess/abnormal adipose tissue impairs their health. Participants must have been diagnosed with at least one of 12 prevalent obesity-related chronic diseases. Data analysis consisted of descriptive statistics.

Results

One in four (26.4%) reported a diagnosis of obesity, but only 9.2% said they had received medically supervised obesity treatment. The majority (55%) agreed obesity makes managing their other chronic diseases challenging; 39% agreed their chronic disease(s) have progressed or gotten worse because of their obesity. While over half (54%) reported being aware that obesity is classified as a chronic disease, 78% responded obesity was their responsibility to manage on their own. Only 33% of respondents responded they have had success with obesity treatment.

Interpretation

While awareness of obesity as a chronic disease is increasing, obesity care within the context of a wider chronic disease management model is suboptimal. More work remains to be done to make Canadian obesity guidelines standard for obesity care.

背景大约15%的加拿大成年人患有两种或两种以上的慢性病，其中许多与肥胖有关。加拿大肥胖治疗指南在多大程度上被纳入慢性病管理尚不清楚。方法我们对2506名符合以下标准之一的加拿大成年人进行了12分钟的在线调查：1）BMI≥30kg/m2；2）肥胖症的医学诊断；3）接受医学监督的肥胖治疗；或4）认为过量/异常的脂肪组织损害了他们的健康。参与者必须至少被诊断患有12种流行的肥胖相关慢性疾病中的一种。数据分析包括描述性统计。结果四分之一（26.4%）的人被诊断为肥胖，但只有9.2%的人表示他们接受过医学监督的肥胖治疗。大多数人（55%）同意肥胖使管理其他慢性疾病具有挑战性；39%的人认为他们的慢性病因为肥胖而发展或恶化。超过一半（54%）的人表示知道肥胖被归类为慢性病，78%的人表示肥胖是他们自己的责任。只有33%的受访者表示他们在肥胖治疗方面取得了成功。解释虽然人们越来越认识到肥胖是一种慢性病，但在更广泛的慢性病管理模式下进行肥胖护理是次优的。要使加拿大肥胖指南成为肥胖护理的标准，还有更多的工作要做。

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引用次数: 0

Helping providers address psychological aspects of obesity in routine care: Development of the obesity adjustment dialogue tool (OADT) 帮助提供者在常规护理中解决肥胖的心理问题:肥胖调整对话工具(OADT)的开发

Obesity Pillars

Pub Date : 2023-09-14 DOI: 10.1016/j.obpill.2023.100088

Michael Vallis

Background

This study developed and validated a dialogue tool (Obesity Adjustment Dialogue Tool) to efficiently assess QoL and drive to eat for use in routine clinical care.

Methods

A 13-question interview was created, assessing the impact of living with obesity on quality of life and drive to eat. In a counter-balanced order, PwO were interviewed and completed the Obesity Adjustment Survey (OAS), the Impact of Obesity on Quality of Life-Lite scale (IWQoL), the Three Factor Eating Questionnaire (TREQ), and the Control of Eating Questionnaire (COEQ). Questionnaire results were used to validate the interview using correlational and concordance measures.

Results

101 PwO consented and 98 completed all measures (mean BMI = 37.8; 30.7% Class III obesity). Correlations between the QoL dialogue tool and validated instruments (OAS, IWQOL) were moderate to high. Correlations between cravings questions and validated measures (TFEQ, COEQ) were high except for attempts to control eating. Correspondence based on categorizing both the dialogue tool and scales into high/low impact was high except for attempts to control eating (which was dropped from the final tool).

Conclusion

The Obesity Adjustment Dialogue Tool is a brief clinician-led structured interview which closely matches information derived from validated scales. This tool offers an efficient approach to incorporating QoL factors into obesity management.

背景本研究开发并验证了一种对话工具（肥胖调整对话工具），用于有效评估日常临床护理中的生活质量和饮食习惯。方法采用13个问题的访谈，评估肥胖对生活质量和饮食冲动的影响。按照反平衡顺序，PwO接受了访谈，并完成了肥胖调整调查（OAS）、肥胖对生活质量的影响Lite量表（IWQoL）、三因素饮食问卷（TREQ）和饮食控制问卷（COEQ）。问卷调查结果用于使用相关性和一致性测量来验证访谈。结果101名PwO同意，98名完成了所有测量（平均BMI=37.8；30.7%为III级肥胖）。生活质量对话工具与经验证的工具（OAS、IWQOL）之间的相关性为中度至高度。食欲问题和有效测量（TFEQ，COEQ）之间的相关性很高，除了试图控制饮食。除了控制饮食的尝试（从最终工具中删除）外，基于对话工具和量表的高/低影响分类的对应性很高。结论肥胖调整对话工具是一个由临床医生主导的简短结构化访谈，与经验证的量表中得出的信息非常匹配。该工具为将生活质量因素纳入肥胖管理提供了一种有效的方法。

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引用次数: 0

Obesity and malnutrition in children and adults: A clinical review 儿童和成人的肥胖和营养不良:临床综述

Obesity Pillars

Pub Date : 2023-09-07 DOI: 10.1016/j.obpill.2023.100087

Morgan Bradley , Julian Melchor , Rachel Carr , Sara Karjoo

Background

In the U.S., children and adults are consuming more low-nutrient foods with added sugar and excess fats as compared to healthy, high-quality calories and micronutrients. This diet is increasing the prevalence of malnutrition and nutritional deficiencies, despite high calorie intake. This is a review of the common micronutrient deficiencies, the risk factors for malnutrition, dietary plans, and the health consequences in children and adults with obesity in the U.S.

Methods

This clinical review of literature was performed on the MEDLINE (PubMed) search engine. A total of 1391 articles were identified and after review, a total of 130 were found to be most pertinent.

Discussion

The most common micronutrient deficiencies found in patients with obesity were vitamin A, thiamine (B1), folate (B9), cobalamin (B12), vitamin D, iron, calcium, and magnesium, especially prior and after bariatric surgery. Diets that produced the most weight reduction also further puts these individuals at risk for worsening malnutrition. Malnutrition and micronutrient deficiencies can worsen health outcomes if not properly managed.

Conclusion

Adequate screening and awareness of malnutrition can improve the health outcomes in patients with obesity. Physiologic changes in response to increased adiposity and inadequate intake increase this population's risk of adverse health effects. Malnutrition affects the individual and contributes to worse public health outcomes. The recommendations for screening for malnutrition are not exclusive to individuals undergoing bariatric procedures and can improve the health outcomes of any patient with obesity. However, clearly, improved nutritional status can assist with metabolism and prevent adverse nutritional outcomes post-bariatric surgery. Clinicians should advise on proper nutrition and be aware of diets that worsen deficiencies.

背景在美国，与健康、高质量的卡路里和微量营养素相比，儿童和成年人摄入的低营养食品更多，添加了糖和多余的脂肪。这种饮食增加了营养不良和营养缺乏的患病率，尽管热量摄入很高。这是对美国常见的微量营养素缺乏症、营养不良的危险因素、饮食计划以及肥胖儿童和成人的健康后果的综述。方法在MEDLINE（PubMed）搜索引擎上对文献进行临床综述。共确定了1391篇文章，经过审查，共发现130篇文章是最相关的。讨论肥胖患者最常见的微量营养素缺乏是维生素A、硫胺素（B1）、叶酸（B9）、钴胺素（B12）、维生素D、铁、钙和镁，尤其是在减肥手术前后。减肥效果最好的饮食也进一步使这些人面临营养不良恶化的风险。如果管理不当，营养不良和微量营养素缺乏会恶化健康状况。结论适当的筛查和营养不良意识可以改善肥胖患者的健康状况。肥胖增加和摄入不足导致的生理变化增加了这一人群的不良健康影响风险。营养不良影响个人，并导致更糟糕的公共卫生结果。营养不良筛查的建议并不局限于接受减肥手术的个人，它可以改善任何肥胖患者的健康状况。然而，很明显，改善营养状况可以帮助新陈代谢，并防止减肥手术后的不良营养后果。临床医生应该就适当的营养提出建议，并注意会加剧营养不足的饮食。

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引用次数: 0

The complexity of obesity-related health problems after bariatric surgery: The patient perspective 减肥手术后肥胖相关健康问题的复杂性:患者视角

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100082

G. Konings , M. Drukker , R. Severeijns , R. Ponds

Background

Bariatric surgery aims to improve quality of life by means of weight loss. Obesity-related physical and psychological health problems should improve, but long-term data are scarce.

Objectives

To evaluate preoperative physical and mental health problems perceived by the patient and the association with weight loss and quality of life, 5 years after bariatric surgery.

Methods

101 persons (response rate 67%) who had had bariatric surgery an average of 4.6 years before this study completed a written survey on obesity-related physical and psychological health problems and three psychological questionnaires collecting information on eating behavior and quality of life. Over half of the participants (55%) had had a laparoscopic adjustable gastric banding.

Results

Preoperatively reported health problems improved but were not necessarily associated with weight loss. Minimal improvement in tiredness, shame and weight instability were associated with significantly less weight loss. Preoperative type 2 diabetes mellitus (T2D) improved but participants had significantly less weight loss and more dissatisfaction regarding the bariatric trajectory than participants without T2D. Eating concerns, emotional eating and external eating improved but not restrained eating. Compared to the Dutch population reference, most quality of life scores of the participants were lower.

Conclusion

In this analysis, participants did report satisfaction although from a patients’ perspective, improvements of weight and health did not necessarily lead to satisfaction regarding the bariatric trajectory. Participants with postoperative reported fatigue and shame as well as participants with preoperative T2D showed significant less weight loss. More long-term research is necessary to close the current knowledge gap.

背景减肥手术旨在通过减肥来提高生活质量。与肥胖相关的身体和心理健康问题应该得到改善，但长期数据很少。目的评估患者在减肥手术后5年的术前身心健康问题及其与体重减轻和生活质量的关系。方法对101名平均4.6年前接受过减肥手术的患者（有效率67%）进行了与肥胖相关的身体和心理健康问题的书面调查，并收集了3份关于饮食行为和生活质量的心理问卷。超过一半的参与者（55%）进行了腹腔镜可调节胃束带术。结果术前报告的健康问题有所改善，但不一定与体重减轻有关。疲劳、羞耻感和体重不稳定的轻微改善与明显减少的体重减轻有关。术前2型糖尿病（T2D）有所改善，但与没有T2D的参与者相比，参与者的体重减轻明显较少，对减肥轨迹的不满程度更高。饮食问题、情绪化饮食和外部饮食改善了，但没有抑制饮食。与荷兰人口参考相比，参与者的大多数生活质量分数都较低。结论在这项分析中，参与者确实报告了满意度，尽管从患者的角度来看，体重和健康的改善并不一定会导致对减肥轨迹的满意度。术后报告疲劳和羞耻的参与者以及术前T2D的参与者的体重减轻明显减少。为了缩小目前的知识差距，需要进行更长期的研究。

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引用次数: 0

How to get back on track? Experiences of patients and healthcare professionals regarding weight recurrence and needs for an intervention after bariatric-metabolic surgery 如何回到正轨?患者和医疗保健专业人员关于体重复发和减肥代谢手术后干预需求的经验

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100074

Vera Voorwinde , Sahar Moukadem , Maartje M. van Stralen , Ignace M.C. Janssen , Valerie M. Monpellier , Ingrid H.M. Steenhuis

Background

Multidisciplinary lifestyle interventions are recommended as a first step in treating weight recurrence after bariatric-metabolic surgery (BMS). However, little is known about the experience of patients and healthcare professionals (HCP) with these interventions and how they should be tailored to the patients’ needs. The aim of this study was to gain more insight into the experiences and needs of patients and HCP regarding weight recurrence after BMS and an intervention to get Back on Track. In addition, attitudes towards integrating e-Health into the care program were explored.

Methods

A qualitative process evaluation of an intervention for weight recurrence, the Back on Track (BoT), was conducted by means of in-depth interviews and focus groups with 19 stakeholders, including patients and HCP involved in BoT. Interviews were transcribed verbatim. Data were analyzed through thematic analysis.

Results

Patients and HCP reported a wide array of causes of weight recurrence. Patients found it difficult to decide when weight recurrence is problematic and when they should ask for help. Patients reported feeling like the exception and ashamed, therefore experiencing a high threshold to seek help. E-Health was seen as a promising way to improve tailoring, screening, autonomy for the patient, and accessible contact.

Conclusion

Patients should be adequately counselled on weight recurrence after BMS and the importance of intervening early. It is important to lower the threshold for seeking help. For example by offering more long-term standard care or by adding e-Health to the intervention.

背景建议将多学科的生活方式干预作为治疗减肥代谢手术（BMS）后体重复发的第一步。然而，人们对患者和医疗保健专业人员（HCP）在这些干预措施方面的经验以及如何根据患者的需求进行调整知之甚少。本研究的目的是深入了解患者和HCP在BMS后体重复发方面的经验和需求，以及重返正轨的干预措施。此外，还探讨了将电子健康纳入护理计划的态度。方法通过对19名利益相关者（包括参与BoT的患者和HCP）进行深入访谈和焦点小组，对体重复发干预措施“回到正轨”（BoT）进行定性过程评估。访谈逐字记录。数据通过专题分析进行分析。结果患者和HCP报告了各种各样的体重复发原因。患者发现很难决定何时体重复发有问题，以及何时应该寻求帮助。患者报告称，他们感觉自己是个例外，感到羞愧，因此寻求帮助的门槛很高。电子健康被视为一种很有前途的方法，可以改善患者的定制、筛查、自主性和可接触性。结论应充分告知患者BMS后的体重复发以及早期干预的重要性。降低寻求帮助的门槛很重要。例如，通过提供更长期的标准护理或在干预中加入电子健康。

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引用次数: 0

Comparing the use of food and physical activity parenting practices: Parents of children with overweight and obesity versus parents of children with a healthy weight 比较使用食物和体育活动的父母做法:超重和肥胖儿童的父母与健康体重儿童的父母

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100078

Lisanne Arayess , Sanne M. Gerards , Junilla K. Larsen , Ester F.C. van der Borgh-Sleddens , Anita C.E. Vreugdenhil

Background

Paediatric overweight and obesity are caused by a complex imbalance between energy intake and expenditure. Parents may influence this imbalance through energy balance-related parenting practices. This study aims to compare the use of energy balance-related parenting practices between parents of children with overweight and obesity and children with a healthy weight.

Methods

This study compares energy balance-related parenting practices among a group of parents with children with overweight and obesity at the start of a lifestyle intervention (N = 107) and children with a healthy weight (N = 137). Specifically, it compares the feeding practices ‘overt control’ (open control over eating), ‘encouragement’, ‘instrumental feeding’, ‘emotional feeding’, and ‘covert control’ (hidden control over eating), as well as the physical activity parenting practice ‘promoting physical activity’. Multiple regression analyses are used to calculate associations between child weight groups and parenting practices when corrected for children's characteristics.

Results

Parents of children with overweight and obesity reported significantly different scores on control over eating practices than parents of children with a healthy weight, namely a significantly higher score on covert control (B = 0.397, S.E. 0.123, p = 0.001) and a significantly lower score for overt control (B = −0.136, S.E. 0.068, p = 0.046).

Conclusion

Covert control is reported more, while overt control is reported less in parents of children with overweight and obesity compared to parents of children with a healthy weight, even after correction for the child's, family, and maternal characteristics. Future longitudinal research and intervention trials are recommended to determine whether and how the use of control over eating practices changes.

背景儿童超重和肥胖是由能量摄入和消耗之间的复杂失衡引起的。父母可能会通过与能量平衡相关的育儿实践来影响这种不平衡。本研究旨在比较超重和肥胖儿童的父母与健康体重儿童在能量平衡相关育儿实践方面的使用情况。方法本研究比较了一组在生活方式干预开始时超重和肥胖儿童（N=107）和健康体重儿童（N=137）的父母与能量平衡相关的育儿实践。具体而言，它比较了“显性控制”（对饮食的公开控制）、“鼓励”、“工具性喂养”、“情感性喂养”和“隐性控制”（饮食的隐性控制）的喂养实践，以及“促进体育活动”的体育活动育儿实践。多元回归分析用于计算校正儿童特征后儿童体重组与育儿实践之间的关联。结果超重和肥胖儿童的父母在饮食控制方面的得分与健康体重儿童的父母显著不同，即隐性控制得分显著较高（B=0.397，S.E.0.123，p=0.001），显性控制得分显著较低（B=−0.136，S.E.0.068，p=0.046），即使在对孩子、家庭和母亲的特征进行校正之后。建议未来进行纵向研究和干预试验，以确定对饮食习惯的控制是否以及如何改变。

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引用次数: 0

Comprehensive care for patients with obesity: An Obesity Medicine Association Position Statement 肥胖症患者的综合护理:肥胖症医学协会立场声明

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100070

Angela Fitch , Lydia Alexander , Carolynn Francavilla Brown , Harold Edward Bays

引用次数: 4

Diagnostic challenge: A pediatric patient with severe obesity and complications of imminent death 诊断挑战:一名患有严重肥胖和即将死亡并发症的儿科患者

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100077

Gitanjali Srivastava

Background

A 15-year-old patient suffering from severe obesity (400 pounds, BMI 71.6 kg/m²) with a clinical phenotype suggestive of syndromic obesity was hospitalized for severe heart failure and cardiogenic shock. The hospital admission prompted a palliative care and heart transplant consultation given end-stage-disease and poor prognosis. It further necessitated a pediatric inpatient obesity consult, which was complicated by several significant hurdles including lack of insurance coverage, FDA approvals, availability of medications, and inadequate knowledge among the medical community.

Methods

Innovative treatment, proactive, persistent advocacy, anti-obesity medication combination strategies modeled after diabetes and hypertension treatment algorithms, and latest evidence in obesity management were utilized to effectively and expeditiously overcome major challenges to care and the medical emergency.

Results

The patient was stabilized and ultimately discharged home, after −25.2% weight loss over 4 months (weight down to 299 pounds, BMI 49.9 kg/m²) through collaborative medical obesity intervention.

Conclusion

The typical delay in care sought by patients suffering from obesity, often due to stigma and lack of disease awareness, results in missed opportunities to prevent serious obesity-related complications. Skilled specialist expertise, fund of obesity-specific knowledge, and constant advocacy can be crucial in surmounting regulatory barriers to obesity care and in generating successful weight loss outcomes.

背景一名患有严重肥胖（400磅，BMI 71.6 kg/m2）的15岁患者因严重心力衰竭和心源性休克住院，其临床表型提示为综合征性肥胖。考虑到末期疾病和预后不佳，入院后进行了姑息治疗和心脏移植咨询。这进一步需要进行儿科住院肥胖咨询，这因几个重大障碍而变得复杂，包括缺乏保险、美国食品药品监督管理局批准、药物可用性以及医学界知识不足。方法利用创新治疗、积极、持续的宣传、模仿糖尿病和高血压治疗算法的抗肥胖药物组合策略，以及肥胖管理的最新证据，有效、迅速地克服护理和医疗紧急情况方面的重大挑战。结果患者在4个月内体重减轻了25.2%（体重降至299磅，BMI为49.9 kg/m2），通过协作性肥胖医疗干预，病情稳定，最终出院回家。结论肥胖患者寻求护理的典型延迟，通常是由于耻辱感和缺乏疾病意识，导致错过了预防严重肥胖相关并发症的机会。熟练的专业知识、专门针对肥胖的知识基金和持续的宣传对于克服肥胖护理的监管障碍和成功减肥至关重要。

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引用次数: 0

Successful treatment of binge eating disorder with the GLP-1 agonist semaglutide: A retrospective cohort study GLP-1激动剂西马鲁肽成功治疗暴食症:一项回顾性队列研究

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100080

Jesse Richards , Neha Bang , Erin L. Ratliff , Maria A. Paszkowiak , Zhamak Khorgami , Sahib S. Khalsa , W. Kyle Simmons

Objective

Binge eating disorder (BED) is the most common eating disorder, and yet only one pharmacotherapy (lisdexamfetamine), which has known abuse-potential, is FDA-approved. Topiramate is also commonly prescribed off-label for binge eating but has many contraindications. In contrast, the glucagon-like peptide-1 (GLP1) analog semaglutide has profound effects on central satiety signaling leading to reduced food intake, and has been approved for the treatment of obesity based on its efficacy and safety profile. Semaglutide would thus seem to be a potential candidate for the treatment of BED.

Methods

This open-label study examined the effects of semaglutide on Binge Eating Scale (BES) scores in individuals with BED. Patients were divided into three groups: those prescribed semaglutide, those prescribed either lisdexamphetamine or topiramate, and those prescribed a combination of semaglutide with lisdexamphetamine or topiramate.

Results

Patients receiving semaglutide only exhibited greater reductions in BES scores compared to the other groups. Combined pharmacotherapy with both semaglutide and the other anti-obesity medications did not result in greater reductions in BES scores compared to the semaglutide-only group. Findings were similar in patients with moderate/severe BED, as well as the full sample.

Conclusion

The therapeutic effects of semaglutide in binge eating disorder warrant further investigation.

Binge饮食障碍（BED）是最常见的饮食障碍，但只有一种已知有滥用潜力的药物疗法（利沙非他明）获得了美国食品药品监督管理局的批准。托吡酯通常也被标示外用于暴饮，但有许多禁忌症。相比之下，胰高血糖素样肽-1（GLP1）类似物semaglutide对中枢饱腹感信号具有深远影响，导致食物摄入减少，并已根据其疗效和安全性被批准用于治疗肥胖。因此，Semagudie似乎是治疗BED的潜在候选药物。方法本项开放标签研究考察了赛马鲁肽对BED患者Binge Eating Scale（BES）评分的影响。患者被分为三组：服用塞米鲁肽的患者、服用利右苯丙胺或托吡酯的患者，以及服用塞米鲁肽与利右苯安非他明或托吡酸联合用药的患者。结果与其他组相比，接受赛马鲁肽治疗的患者BES评分下降幅度更大。与仅使用赛马鲁肽的组相比，同时使用赛马鲁肽和其他抗肥胖药物的联合药物治疗并没有导致BES评分的更大降低。中度/重度BED患者和全样本的结果相似。结论赛马鲁肽治疗暴饮性饮食障碍的疗效值得进一步研究。

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引用次数: 1

Whole-body bone mineral density and markers of bone homeostasis in adults with normal-weight obesity 正常体重肥胖成人的全身骨密度和骨稳态指标

Obesity Pillars

Pub Date : 2023-09-01 DOI: 10.1016/j.obpill.2023.100073

Bryant H. Keirns , Christina M. Sciarrillo , Austin R. Medlin , Samantha M. Hart , Elyse M. Cronic , Sam R. Emerson

Background

Normal-weight obesity (NWO) describes individuals with a normal body mass index (BMI), but high body fat percent. NWO are at-risk for cardiometabolic diseases, but little is known about their bone health.

Methods

Adults (N = 24) were classified as NWO (n = 12; 5M/7F) or low body fat percent controls (Con; n = 12; 6M/6F). Body composition and whole-body bone mineral density (BMD) were assessed using DXA. A serum bioplex assay was performed to examine markers related to bone formation and resorption.

Results

In addition to higher body fat percent and visceral fat, NWO had lower whole-body BMD relative to Con (p's < 0.05). Circulating leptin was higher in NWO than Con (p < 0.05). Two biomarkers generally associated with lower bone mass – sclerostin and parathyroid hormone – were higher in NWO compared to Con (p's < 0.05).

Conclusion

In this preliminary study, adults with NWO displayed lower whole-body BMD alongside evidence of bone resorption. Impaired bone health may be another subclinical risk factor present in NWO.

背景正常体重肥胖（NWO）是指体重指数（BMI）正常，但体脂百分比较高的个体。NWO有患心脏代谢疾病的风险，但对其骨骼健康知之甚少。方法将成年人（N=24）分为NWO（N=12；5M/7F）或低体脂百分比对照组（Con；N=12；6M/6F）。使用DXA评估身体成分和全身骨密度（BMD）。进行血清生物复合物测定以检查与骨形成和骨吸收相关的标志物。结果除了较高的体脂百分比和内脏脂肪外，与Con相比，NWO的全身BMD较低（p’s<；0.05）。NWO的循环瘦素高于Con（p＜0.05）。通常与较低骨量相关的两种生物标志物——硬化素和甲状旁腺激素——在NWO中高于Con。结论在本初步研究中，患有NWO的成年人显示出较低的全身BMD以及骨吸收的证据。骨健康受损可能是NWO中存在的另一个亚临床风险因素。

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引用次数: 1