Hui-Qin Xing, Xiaodan Du, Nuerbiyemu Abulikemu, Jing Yang, Xin Gao, Jundi Liu, Chunhui Jiang, Jingwen Li, Jian Wang
OBJECTIVE: To investigate the feasibility of diffusion-weighted imaging (DWI) and signal-to-noise ratio (SNR) of lesions in evaluating the efficacy of albendazole liposomes in the treatment of cerebral alveolar echinococcosis (CAE). MATERIALS AND METHODS: Sixteen patients with CAE who met the inclusion criteria from April 2017 to December 2020 were enrolled. All patients underwent routine magnetic resonance sequence examination and DWI examination. The b-value were 1000 s/mm2 and 3000 s/mm2. The apparent diffusion coefficient (ADC) value and SNR of lesions before and after treatment were compared. The data of each group were statistically analyzed by Wilcoxon signed-rank sum test. RESULTS: After 1 year of treatment with albendazole liposomes, the SNR of lesions on T2WI sequence increased. There was a significant difference between the SNR of the same lesion before and after follow-up (P < 0.05). The ADC values of lesion parenchyma and edema area before and after treatment were compared. The difference between them was statistically significant in the both b values (ADC of parenchyma, P < 0.05; ADC of edema area, P < 0.001). Through binary linear classification, it was found that under the same b value, the effect of drugs on the edema area was more obvious than that on the parenchyma area; under different b values, the higher the b value, the higher the ability to evaluate the curative effect of drug therapy. CONCLUSION: Albendazole liposome is effective in the treatment of CAE, and long-term imaging follow-up of patients with CAE treated with albendazole liposome is necessary. When the change in conventional images is inapparent, the quantitative analysis of ADC value and SNR of lesions on T2WI can provide an objective basis for the evaluation of the curative effect of drug treatment in CAE.
目的:探讨病变弥散加权成像(DWI)和信噪比(SNR)评价阿苯达唑脂质体治疗脑肺泡包虫病(CAE)疗效的可行性。材料与方法:纳入2017年4月至2020年12月期间符合纳入标准的16例CAE患者。所有患者均行常规磁共振序列检查和DWI检查。b值分别为1000 s/mm2和3000 s/mm2。比较治疗前后病变的表观扩散系数(ADC)值和信噪比。各组数据采用Wilcoxon sign -rank和检验进行统计学分析。结果:阿苯达唑脂质体治疗1年后，T2WI序列病灶信噪比升高。同一病灶随访前后信噪比比较，差异有统计学意义(P < 0.05)。比较治疗前后病变实质及水肿面积的ADC值。两组间b值差异均有统计学意义(实质ADC, P < 0.05;水肿面积ADC, P < 0.001)。通过二元线性分类发现，在相同的b值下，药物对水肿面积的影响比对实质面积的影响更明显;在不同b值下，b值越高，对药物治疗疗效的评价能力越高。结论:阿苯达唑脂质体治疗CAE有效，对阿苯达唑脂质体治疗CAE的患者进行长期影像学随访是必要的。在常规图像变化不明显的情况下，定量分析T2WI病变的ADC值和信噪比，可为评价CAE药物治疗的疗效提供客观依据。
{"title":"Quantitative analysis of diffusion-weighted imaging and signal-to-noise ratio on the efficacy of albendazole liposome in the treatment of cerebral alveolar echinococcosis","authors":"Hui-Qin Xing, Xiaodan Du, Nuerbiyemu Abulikemu, Jing Yang, Xin Gao, Jundi Liu, Chunhui Jiang, Jingwen Li, Jian Wang","doi":"10.4103/rid.rid_10_21","DOIUrl":"https://doi.org/10.4103/rid.rid_10_21","url":null,"abstract":"OBJECTIVE: To investigate the feasibility of diffusion-weighted imaging (DWI) and signal-to-noise ratio (SNR) of lesions in evaluating the efficacy of albendazole liposomes in the treatment of cerebral alveolar echinococcosis (CAE). MATERIALS AND METHODS: Sixteen patients with CAE who met the inclusion criteria from April 2017 to December 2020 were enrolled. All patients underwent routine magnetic resonance sequence examination and DWI examination. The b-value were 1000 s/mm2 and 3000 s/mm2. The apparent diffusion coefficient (ADC) value and SNR of lesions before and after treatment were compared. The data of each group were statistically analyzed by Wilcoxon signed-rank sum test. RESULTS: After 1 year of treatment with albendazole liposomes, the SNR of lesions on T2WI sequence increased. There was a significant difference between the SNR of the same lesion before and after follow-up (P < 0.05). The ADC values of lesion parenchyma and edema area before and after treatment were compared. The difference between them was statistically significant in the both b values (ADC of parenchyma, P < 0.05; ADC of edema area, P < 0.001). Through binary linear classification, it was found that under the same b value, the effect of drugs on the edema area was more obvious than that on the parenchyma area; under different b values, the higher the b value, the higher the ability to evaluate the curative effect of drug therapy. CONCLUSION: Albendazole liposome is effective in the treatment of CAE, and long-term imaging follow-up of patients with CAE treated with albendazole liposome is necessary. When the change in conventional images is inapparent, the quantitative analysis of ADC value and SNR of lesions on T2WI can provide an objective basis for the evaluation of the curative effect of drug treatment in CAE.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"4 1","pages":"133 - 139"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72936793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Computed tomography (CT) examination plays an indispensable role in the diagnosis of coronavirus disease-2019 (COVID-19). Many studies have evaluated the severity of COVID-19 based on CT images, with the severity of COVID-19 being evaluated either manually or by using artificial intelligence. In this review, the recently reported methods for manually evaluating COVID-19 severity based on CT images are summarized and divided into three categories: evaluation based on the extent of abnormalities; evaluation based on the characteristics of abnormalities; and evaluation based on both the extent and characteristics of abnormalities.
{"title":"Manual severity evaluation methods for novel coronavirus pneumonia based on computed tomography imaging","authors":"Qiang Chen, L. Luo","doi":"10.4103/rid.rid_20_22","DOIUrl":"https://doi.org/10.4103/rid.rid_20_22","url":null,"abstract":"Computed tomography (CT) examination plays an indispensable role in the diagnosis of coronavirus disease-2019 (COVID-19). Many studies have evaluated the severity of COVID-19 based on CT images, with the severity of COVID-19 being evaluated either manually or by using artificial intelligence. In this review, the recently reported methods for manually evaluating COVID-19 severity based on CT images are summarized and divided into three categories: evaluation based on the extent of abnormalities; evaluation based on the characteristics of abnormalities; and evaluation based on both the extent and characteristics of abnormalities.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"61 1","pages":"158 - 167"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80660911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study on the diagnostic value of chest X-ray and computed tomography in patients with COVID- 19","authors":"Lingbo Deng, Yi Zhu, Wen Zhou, Guanxun Cheng","doi":"10.4103/rid.rid_18_22","DOIUrl":"https://doi.org/10.4103/rid.rid_18_22","url":null,"abstract":"","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"42 1","pages":"168 - 169"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86447963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: Previous studies showed a significant correlation between fatty liver (FL) and acute pancreatitis (AP) onset, but the impact of FL on AP severity and prognosis remains uncertain. Therefore, we systematically searched existing publications in English and Chinese and conducted a meta-analysis to evaluate the effect of FL on AP severity and prognosis. OBJECTIVE: The purpose of this study was to analyze the correlation between FL and AP severity and prognosis. MATERIALS AND METHODS: All published controlled clinical studies on the relationship between FL and AP were identified by searching available electronic databases. We assessed the impact of FL disease on AP biochemical indicators, severity, and prognosis using pooled individual studies with an odds ratio (OR), standardized mean difference, and weighted mean difference. RESULTS: Thirteen clinical case − control studies met the meta-analysis entry criteria, and these studies included 6570 patients; among them, 2110 were patients with FL-relatedAP (FLAP) and 4460 were patients with non-FL-related AP (NFLAP). The meta-analysis results showed that the percentage of mild AP in FLAP was lower than that in NFLAP (OR = 0.32, P < 0.001), but the percentage of moderately severe AP (MSAP) and severe AP (SAP) in FLAP was higher than that in NFLAP (OR = 2.66 and 2.57, respectively, P < 0.001). The various prognostic indicators included the acute physiology and chronic health evaluation II score, systemic complications, local complications, total length of hospital stay, and mortality, which were all significantly higher in FLAP than in NFLAP (P < 0.05 for all). CONCLUSION: AP severity and prognosis were different between FLAP and NFLAP patients, and FL could be used as an independent risk factor for MSAP and SAP.
{"title":"Impact of fatty liver on acute pancreatitis severity and prognosis: A meta-analysis of English and Chinese studies","authors":"Mingkuan Jiang, Miao Zhang, Lirong Zhang, Linting Luo, Qian Chen","doi":"10.4103/rid.rid_10_22","DOIUrl":"https://doi.org/10.4103/rid.rid_10_22","url":null,"abstract":"BACKGROUND: Previous studies showed a significant correlation between fatty liver (FL) and acute pancreatitis (AP) onset, but the impact of FL on AP severity and prognosis remains uncertain. Therefore, we systematically searched existing publications in English and Chinese and conducted a meta-analysis to evaluate the effect of FL on AP severity and prognosis. OBJECTIVE: The purpose of this study was to analyze the correlation between FL and AP severity and prognosis. MATERIALS AND METHODS: All published controlled clinical studies on the relationship between FL and AP were identified by searching available electronic databases. We assessed the impact of FL disease on AP biochemical indicators, severity, and prognosis using pooled individual studies with an odds ratio (OR), standardized mean difference, and weighted mean difference. RESULTS: Thirteen clinical case − control studies met the meta-analysis entry criteria, and these studies included 6570 patients; among them, 2110 were patients with FL-relatedAP (FLAP) and 4460 were patients with non-FL-related AP (NFLAP). The meta-analysis results showed that the percentage of mild AP in FLAP was lower than that in NFLAP (OR = 0.32, P < 0.001), but the percentage of moderately severe AP (MSAP) and severe AP (SAP) in FLAP was higher than that in NFLAP (OR = 2.66 and 2.57, respectively, P < 0.001). The various prognostic indicators included the acute physiology and chronic health evaluation II score, systemic complications, local complications, total length of hospital stay, and mortality, which were all significantly higher in FLAP than in NFLAP (P < 0.05 for all). CONCLUSION: AP severity and prognosis were different between FLAP and NFLAP patients, and FL could be used as an independent risk factor for MSAP and SAP.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"65 1","pages":"140 - 149"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80905222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reduction of door-to-chest computed tomographic time in a fever clinic following anti-COVID-19 efforts","authors":"Yu Yang, Minggui Lin, Weiwei Wu","doi":"10.4103/rid.rid_24_21","DOIUrl":"https://doi.org/10.4103/rid.rid_24_21","url":null,"abstract":"","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"9 1","pages":"174 - 176"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74270799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Tang, Sihong Huang, Xingzhi Xie, Ru Yang, Xiaohong Wang, Juan Zhou, J. Liu
OBJECTIVE: Since the coronavirus disease 2019 (COVID-19) outbreak in Wuhan in 2019, the virus has spread rapidly. We investigated the clinical and computed tomography (CT) characteristics of different clinical types of COVID-19. MATERIALS AND METHODS: We retrospectively analyzed clinical and chest CT findings of 89 reverse transcription polymerase chain reaction confirmed cases from five medical centers in China. All the patients were classified into the common (n = 65), severe (n = 18), or fatal (n = 6) type. CT features included lesion distribution, location, size, shape, edge, density, and the ratio of lung lesions to extra-pulmonary lesions. A COVID-19 chest CT analysis tool (uAI-discover-COVID-19) was used to calculate the number of infections from the chest CT images. RESULTS: Fatal type COVID-19 is more common in older men, with a median age of 65 years. Fever was more common in the severe and fatal type COVID-19 patients than in the common type patients. Patients with fatal type COVID-19 were more likely to have underlying diseases. On CT examination, common type COVID-19 showed bilateral (68%), patchy (83%), ground-glass opacity (48%), or mixed (46%) lesions. Severe and fatal type COVID-19 showed bilateral multiple mixed density lesions (56%). The infection ratio (IR) increased in the common type (2.4 [4.3]), severe type (15.7 [14.3]), and fatal type (36.9 [14.2]). The IR in the inferior lobe of both lungs was statistically different from that of other lobes in common and severe type patients (P < 0.05). However, in the fatal type group, only the IR in the right inferior lung (RIL) was statistically different from that in the right superior lung(RUL), right middle lung (RML), and the left superior lung (LSL) (P < 0.05). CONCLUSION: The CT findings and clinical features of the various clinical types of COVID-19 pneumonia are different. Chest CT findings have unique characteristics in the different clinical types, which can facilitate an early diagnosis and evaluate the clinical course and severity of COVID-19.
{"title":"Computed tomography findings and clinical manifestations in different clinical types of coronavirus disease 2019","authors":"F. Tang, Sihong Huang, Xingzhi Xie, Ru Yang, Xiaohong Wang, Juan Zhou, J. Liu","doi":"10.4103/rid.rid_6_22","DOIUrl":"https://doi.org/10.4103/rid.rid_6_22","url":null,"abstract":"OBJECTIVE: Since the coronavirus disease 2019 (COVID-19) outbreak in Wuhan in 2019, the virus has spread rapidly. We investigated the clinical and computed tomography (CT) characteristics of different clinical types of COVID-19. MATERIALS AND METHODS: We retrospectively analyzed clinical and chest CT findings of 89 reverse transcription polymerase chain reaction confirmed cases from five medical centers in China. All the patients were classified into the common (n = 65), severe (n = 18), or fatal (n = 6) type. CT features included lesion distribution, location, size, shape, edge, density, and the ratio of lung lesions to extra-pulmonary lesions. A COVID-19 chest CT analysis tool (uAI-discover-COVID-19) was used to calculate the number of infections from the chest CT images. RESULTS: Fatal type COVID-19 is more common in older men, with a median age of 65 years. Fever was more common in the severe and fatal type COVID-19 patients than in the common type patients. Patients with fatal type COVID-19 were more likely to have underlying diseases. On CT examination, common type COVID-19 showed bilateral (68%), patchy (83%), ground-glass opacity (48%), or mixed (46%) lesions. Severe and fatal type COVID-19 showed bilateral multiple mixed density lesions (56%). The infection ratio (IR) increased in the common type (2.4 [4.3]), severe type (15.7 [14.3]), and fatal type (36.9 [14.2]). The IR in the inferior lobe of both lungs was statistically different from that of other lobes in common and severe type patients (P < 0.05). However, in the fatal type group, only the IR in the right inferior lung (RIL) was statistically different from that in the right superior lung(RUL), right middle lung (RML), and the left superior lung (LSL) (P < 0.05). CONCLUSION: The CT findings and clinical features of the various clinical types of COVID-19 pneumonia are different. Chest CT findings have unique characteristics in the different clinical types, which can facilitate an early diagnosis and evaluate the clinical course and severity of COVID-19.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"31 1","pages":"101 - 107"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79407979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yahong Gong, XiaoMing Gong, Kai Zhang, Lu Song, Yipan Li, Hengning Ke, Zhiyan Lu
OBJECTIVE: To analyze the clinical characteristics, pathological characteristics, and prognostic factors of AIDS-related lymphoma (ARL). MATERIALS AND METHODS: This was a retrospective study of the clinical characteristics, diagnosis and treatment process, and survival status of 32 patients with ARL. The patients were divided into a survival group and nonsurvival group according to their prognosis, and the factors affecting survival were analyzed. The patients' clinical characteristics were analyzed according to symptoms, sex, age, and laboratory indicators such as the lactate dehydrogenase (LDH) concentration, number of CD4+ T cells, Ann Arbor stage, pathological typing, and international prognostic index (IPI) score. A univariate regression analysis was performed to compare the clinical characteristics of the treatment group and nontreatment group. The impact of chemotherapy and combined antiviral therapy on survival time was assessed. RESULTS: Thirty-two patients were included in the study; 31 were male and 23 were aged >40 years. The average LDH concentration was 639.8 U/L, and the average CD4+ lymphocyte count was 167 cells/μL. Diffuse large B-cell lymphoma was present in 40.6% (13/32) of the patients; a B-lymphocyte source accounted for 90.6% (29/32) of cases, and a T-lymphocyte source accounted for 9.4% (3/32). The proportion of patients who received anti-lymphoma treatment was 84.4% (27/32). Twenty-three patients died during follow-up and nine survived. Univariate analysis showed that the prognostic factors were age, the CD4+ T-lymphocyte count, and the IPI score. The average progression-free survival (PFS) time in the highly active antiretroviral therapy (HAART) group before chemotherapy was 4.81 months, while the average PFS time without antiviral therapy before chemotherapy was about 1.91 months. This difference was statistically significant. The median 2-year survival time in patients who received antiviral therapy before chemotherapy was 33.3 months, while that in patients who did not receive antiviral therapy was 27.3 months. Early HAART therapy combined with standardized chemotherapy was shown to improve the patients' prognosis. It also improved the overall survival (OS) rate and PFS time. However, there was no significant difference in the OS rates between 1 and 2 years. CONCLUSION: The CD4+ T-cell count and IPI score were key factors affecting the prognosis of patients with ARL. An increased LDH concentration was also a prognostic factor. A certain correlation between the disease severity and prognosis was found. The use of standard anti-lymphoma treatment can effectively improve the survival rate of patients.
{"title":"Analysis of clinical features and prognostic factors of AIDS-related lymphoma","authors":"Yahong Gong, XiaoMing Gong, Kai Zhang, Lu Song, Yipan Li, Hengning Ke, Zhiyan Lu","doi":"10.4103/rid.rid_5_22","DOIUrl":"https://doi.org/10.4103/rid.rid_5_22","url":null,"abstract":"OBJECTIVE: To analyze the clinical characteristics, pathological characteristics, and prognostic factors of AIDS-related lymphoma (ARL). MATERIALS AND METHODS: This was a retrospective study of the clinical characteristics, diagnosis and treatment process, and survival status of 32 patients with ARL. The patients were divided into a survival group and nonsurvival group according to their prognosis, and the factors affecting survival were analyzed. The patients' clinical characteristics were analyzed according to symptoms, sex, age, and laboratory indicators such as the lactate dehydrogenase (LDH) concentration, number of CD4+ T cells, Ann Arbor stage, pathological typing, and international prognostic index (IPI) score. A univariate regression analysis was performed to compare the clinical characteristics of the treatment group and nontreatment group. The impact of chemotherapy and combined antiviral therapy on survival time was assessed. RESULTS: Thirty-two patients were included in the study; 31 were male and 23 were aged >40 years. The average LDH concentration was 639.8 U/L, and the average CD4+ lymphocyte count was 167 cells/μL. Diffuse large B-cell lymphoma was present in 40.6% (13/32) of the patients; a B-lymphocyte source accounted for 90.6% (29/32) of cases, and a T-lymphocyte source accounted for 9.4% (3/32). The proportion of patients who received anti-lymphoma treatment was 84.4% (27/32). Twenty-three patients died during follow-up and nine survived. Univariate analysis showed that the prognostic factors were age, the CD4+ T-lymphocyte count, and the IPI score. The average progression-free survival (PFS) time in the highly active antiretroviral therapy (HAART) group before chemotherapy was 4.81 months, while the average PFS time without antiviral therapy before chemotherapy was about 1.91 months. This difference was statistically significant. The median 2-year survival time in patients who received antiviral therapy before chemotherapy was 33.3 months, while that in patients who did not receive antiviral therapy was 27.3 months. Early HAART therapy combined with standardized chemotherapy was shown to improve the patients' prognosis. It also improved the overall survival (OS) rate and PFS time. However, there was no significant difference in the OS rates between 1 and 2 years. CONCLUSION: The CD4+ T-cell count and IPI score were key factors affecting the prognosis of patients with ARL. An increased LDH concentration was also a prognostic factor. A certain correlation between the disease severity and prognosis was found. The use of standard anti-lymphoma treatment can effectively improve the survival rate of patients.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"239 1","pages":"95 - 100"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82881767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Xiang, Ningqin Li, Zhongyang Zhou, Jing Fang, Jin-yuan Liao
OBJECTIVE: The objective of the study is to explore the feasibility of Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) T1 mapping for evaluating liver damage caused by Clonorchis sinensis infection in rabbit models. MATERIALS AND METHODS: Forty-two rabbits were randomly divided into a control group (n = 10), mild infection group (n = 12), moderate infection group (n = 9), and severe infection group (n = 11). All rabbits underwent an magnetic resonance imaging scan and pathological examination to obtain the relaxation time before Gd-EOB-DTPA enhancement and the relaxation time after Gd-EOB-DTPA enhancement at intervals of 10, 15, 20, 25, 30, 35, and 40 min. The Ishak score was used to evaluate the inflammation and fibrosis of the liver. RESULTS: The severity of C. sinensis infection was positively correlated with liver inflammation. The T1 relaxation time of liver increased with increasing inflammation. The highest correlation was recorded between inflammation and the T1 relaxation time at 30 min (P = 0.001). After enhancement, The T1 relaxation time has a significant difference between the severe infection group and control group and between the severe infection group and mild infection group. The area under the receiver operating characteristics curve showed that the T1 relaxation time was the most effective parameter for diagnosing the degree of inflammation at 30 min. CONCLUSIONS: Gd-EOB-DTPA-enhanced T1 mapping can be used to evaluate the liver damage caused by C. sinensis infection.
{"title":"Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced T1 mapping to evaluate liver damage caused by Clonorchis sinensis","authors":"Y. Xiang, Ningqin Li, Zhongyang Zhou, Jing Fang, Jin-yuan Liao","doi":"10.4103/rid.rid_26_21","DOIUrl":"https://doi.org/10.4103/rid.rid_26_21","url":null,"abstract":"OBJECTIVE: The objective of the study is to explore the feasibility of Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) T1 mapping for evaluating liver damage caused by Clonorchis sinensis infection in rabbit models. MATERIALS AND METHODS: Forty-two rabbits were randomly divided into a control group (n = 10), mild infection group (n = 12), moderate infection group (n = 9), and severe infection group (n = 11). All rabbits underwent an magnetic resonance imaging scan and pathological examination to obtain the relaxation time before Gd-EOB-DTPA enhancement and the relaxation time after Gd-EOB-DTPA enhancement at intervals of 10, 15, 20, 25, 30, 35, and 40 min. The Ishak score was used to evaluate the inflammation and fibrosis of the liver. RESULTS: The severity of C. sinensis infection was positively correlated with liver inflammation. The T1 relaxation time of liver increased with increasing inflammation. The highest correlation was recorded between inflammation and the T1 relaxation time at 30 min (P = 0.001). After enhancement, The T1 relaxation time has a significant difference between the severe infection group and control group and between the severe infection group and mild infection group. The area under the receiver operating characteristics curve showed that the T1 relaxation time was the most effective parameter for diagnosing the degree of inflammation at 30 min. CONCLUSIONS: Gd-EOB-DTPA-enhanced T1 mapping can be used to evaluate the liver damage caused by C. sinensis infection.","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"33 1","pages":"108 - 115"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83896559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jian Wang, Bo Ren, Aierken Aikebaier, -. Ailixire, Wenya Liu
{"title":"Magnetic resonance cholangiopancreatography evaluation of the biliary tract in hepatic alveolar echinococcosis before autotransplantation","authors":"Jian Wang, Bo Ren, Aierken Aikebaier, -. Ailixire, Wenya Liu","doi":"10.4103/rid.rid_7_22","DOIUrl":"https://doi.org/10.4103/rid.rid_7_22","url":null,"abstract":"","PeriodicalId":101055,"journal":{"name":"Radiology of Infectious Diseases","volume":"8 1","pages":"130 - 132"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87510356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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