Pub Date : 2017-06-25DOI: 10.3969/CJCNN.V17I6.1610
Weijun Gong
Neural prosthesis is based on brain-computer interface (BCI), which directly acts on the muscle system or an external device by analyzing EEG control commands, so as to compensate the efferent pathway of brain-spinal cord-muscle and recover motor function of patients with spinal cord injury. The technology involves comprehensive research of multiple disciplines such as brain science, cognitive neuroscience, biomedical engineering, information and communication engineering, control science and engineering. This paper reviews recent advances of neural prosthesis in the rehabilitation treatment of patients with spinal cord injury. DOI: 10.3969/j.issn.1672-6731.2017.06.002
{"title":"Application progress of neural prosthesis in rehabilitation of patients with spinal cord injury","authors":"Weijun Gong","doi":"10.3969/CJCNN.V17I6.1610","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I6.1610","url":null,"abstract":"Neural prosthesis is based on brain-computer interface (BCI), which directly acts on the muscle system or an external device by analyzing EEG control commands, so as to compensate the efferent pathway of brain-spinal cord-muscle and recover motor function of patients with spinal cord injury. The technology involves comprehensive research of multiple disciplines such as brain science, cognitive neuroscience, biomedical engineering, information and communication engineering, control science and engineering. This paper reviews recent advances of neural prosthesis in the rehabilitation treatment of patients with spinal cord injury. DOI: 10.3969/j.issn.1672-6731.2017.06.002","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"399-402"},"PeriodicalIF":0.0,"publicationDate":"2017-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-01DOI: 10.3969/CJCNN.V17I6.1613
Weijun Gong
Objective To explore the rehabilitation effect of motor imagery therapy on cognitive function of stroke patients. Methods A total of 99 stroke patients with mild to moderate cognitive dysfunction were randomly divided into 3 groups: control group (N = 33), cognitive training group (N = 33) and motor imagery training group (N = 33). All patients received conventional rehabilitation training. Before and after 8-week training, all subjects were assessed with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). At the same time, event-related potential (ERP) was examined to detect P300 latency and amplitude. Results ompared with before training, MMSE ( P = 0.000) and MoCA ( P = 0.000) scores were significantly increased, P300 latency was shortened ( P = 0.000) and P300 amplitude was increased ( P = 0.000) in 3 groups after 8 - week training. There were significant differences among 3 groups on MMSE ( P = 0.030) and MoCA ( P = 0.013) scores, P300 latency ( P = 0.004) and P300 amplitude ( P = 0.009) before and after training. Among them, cognitive training group and motor imagery training group had significantly higher MMSE ( P = 0.019, 0.021) and MoCA ( P = 0.003, 0.031) scores, shorter P300 latency ( P = 0.020, 0.003) and higher P300 amplitude ( P = 0.003, 0.002) than control group. Conclusions Motor imagery training can not only improve motor function of stroke patients, but also improve their cognitive function. DOI: 10.3969/j.issn.1672-6731.2017.06.005
{"title":"Effect of motor imagery therapy on cognitive function of patients with stroke","authors":"Weijun Gong","doi":"10.3969/CJCNN.V17I6.1613","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I6.1613","url":null,"abstract":"Objective To explore the rehabilitation effect of motor imagery therapy on cognitive function of stroke patients. Methods A total of 99 stroke patients with mild to moderate cognitive dysfunction were randomly divided into 3 groups: control group (N = 33), cognitive training group (N = 33) and motor imagery training group (N = 33). All patients received conventional rehabilitation training. Before and after 8-week training, all subjects were assessed with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). At the same time, event-related potential (ERP) was examined to detect P300 latency and amplitude. Results ompared with before training, MMSE ( P = 0.000) and MoCA ( P = 0.000) scores were significantly increased, P300 latency was shortened ( P = 0.000) and P300 amplitude was increased ( P = 0.000) in 3 groups after 8 - week training. There were significant differences among 3 groups on MMSE ( P = 0.030) and MoCA ( P = 0.013) scores, P300 latency ( P = 0.004) and P300 amplitude ( P = 0.009) before and after training. Among them, cognitive training group and motor imagery training group had significantly higher MMSE ( P = 0.019, 0.021) and MoCA ( P = 0.003, 0.031) scores, shorter P300 latency ( P = 0.020, 0.003) and higher P300 amplitude ( P = 0.003, 0.002) than control group. Conclusions Motor imagery training can not only improve motor function of stroke patients, but also improve their cognitive function. DOI: 10.3969/j.issn.1672-6731.2017.06.005","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"415-420"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48727108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-25DOI: 10.3969/CJCNN.V17I4.1578
Ming Guo, Jun Zhao, Bing-jie Li, Tong Zhang, Li-ping Mei, Dan Huang
Objective To investigate the effect of respiratory function training on respiratory function and conscious state of patients with severe cerebrovascular disease (SCVD). Methods A total of 27 patients with SCVD were divided into control group (N = 17) and observation group (N = 10). Control group received routine drug and rehabilitation treatment, and observation group was added respiratory function training based on routine treatment. The respiratory rate, tidal volume (TV), heart rate, blood pressure and artery oxygen saturation (SaO 2 ) of patients were monitored by breathing machine before and after 4-week treatment. Meanwhile, arterial blood gas analysis was used to detect arterial partial pressure of oxygen (PaO 2 ), oxygenation index, partial pressure of carbon dioxide (PaCO 2 ) and pH value. At the same time, Glasgow Coma Scale (GCS) was used to evaluate the conscious state of patients. Results All patients successfully completed 4-week rehabilitation training, without asphyxia, arrhythmia or other adverse events. Compared with before training, the respiratory rate ( P = 0.006) and pH value ( P = 0.010) were significantly decreased, while SaO 2 ( P = 0.001), oxygenation index ( P = 0.000) and GCS scores ( P = 0.004, 0.017) were significantly increased in both groups of patients after training. There was no statistically significant difference between 2 groups on respiratory function indexes and GCS scores after training ( P > 0.05, for all). Conclusions Respiratory function training did not significantly improve the respiratory function and conscious state of patients with SCVD, yet to be further studied. Randomized controlled clinical trials with larger, layered samples and long-term prognosis observation are needed. Examination method of respiratory function of SCVD patients is also a topic to be explored. DOI: 10.3969/j.issn.1672-6731.2017.04.007
{"title":"Effect of respiratory function training on respiratory function of patients with severe cerebrovascular disease","authors":"Ming Guo, Jun Zhao, Bing-jie Li, Tong Zhang, Li-ping Mei, Dan Huang","doi":"10.3969/CJCNN.V17I4.1578","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1578","url":null,"abstract":"Objective To investigate the effect of respiratory function training on respiratory function and conscious state of patients with severe cerebrovascular disease (SCVD). Methods A total of 27 patients with SCVD were divided into control group (N = 17) and observation group (N = 10). Control group received routine drug and rehabilitation treatment, and observation group was added respiratory function training based on routine treatment. The respiratory rate, tidal volume (TV), heart rate, blood pressure and artery oxygen saturation (SaO 2 ) of patients were monitored by breathing machine before and after 4-week treatment. Meanwhile, arterial blood gas analysis was used to detect arterial partial pressure of oxygen (PaO 2 ), oxygenation index, partial pressure of carbon dioxide (PaCO 2 ) and pH value. At the same time, Glasgow Coma Scale (GCS) was used to evaluate the conscious state of patients. Results All patients successfully completed 4-week rehabilitation training, without asphyxia, arrhythmia or other adverse events. Compared with before training, the respiratory rate ( P = 0.006) and pH value ( P = 0.010) were significantly decreased, while SaO 2 ( P = 0.001), oxygenation index ( P = 0.000) and GCS scores ( P = 0.004, 0.017) were significantly increased in both groups of patients after training. There was no statistically significant difference between 2 groups on respiratory function indexes and GCS scores after training ( P > 0.05, for all). Conclusions Respiratory function training did not significantly improve the respiratory function and conscious state of patients with SCVD, yet to be further studied. Randomized controlled clinical trials with larger, layered samples and long-term prognosis observation are needed. Examination method of respiratory function of SCVD patients is also a topic to be explored. DOI: 10.3969/j.issn.1672-6731.2017.04.007","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"270-275"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43204226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The patient, a 28 year old male, was admitted to our outpatient clinic on February 19, 2016 due to progressive weakness of the distal right upper limb with muscle atrophy for 5 years. 5 years ago, the patient had no obvious cause of weakness in the right hand fingers, which worsened during cold weather. Gradually, the right hand fingers became clumsy and unable to move together, and fine movements such as threading needles and wires were significantly restricted. The symptoms persisted without significant relief, accompanied by atrophy of the right hand muscles, no obvious jumping sensation, normal movement of other limbs, no pain, numbness or other sensory abnormalities, no speech disorders, swallowing difficulties, etc. Since the onset of the disease, the patient's mental state, sleep, and diet have been moderate, with no significant abnormalities in bowel and bowel movements, and no significant changes in weight. There is no special history in the past, personal history, or family history. The individual reported significant height growth between the ages of 15 and 18 (specific details are not available). Physical examination after admission: The patient's body temperature is 36.7 ° C, pulse rate is 71 times/min, respiration is 16 times/min, blood pressure is 115/65 mm Hg (1 mm Hg=0.133 kPa); Clear consciousness, fluent language, with equal and round pupils on both sides, with a diameter of approximately 3 mm. No obvious abnormalities were found in the nervous system during physical examination; Atrophy of the thenar and interosseous muscles in the right hand, no obvious muscle atrophy in the left hand, and tremors in the hand muscles can be observed when extending the hands. The distal muscle strength of the right upper limb is 3+to 4 levels, and the muscle tension is reduced. The proximal and left limb muscle strength is 5 levels, and the muscle tension is normal. The radial periosteal reflex, biceps reflex, and triceps reflex in the right upper limb are strongly positive, while the left upper limb is positive. Both Hoffmann and Babinski signs are negative, No obvious abnormalities were observed in the ataxia and deep and shallow sensations, and the meningeal stimulation sign was negative. All indicators tested in the laboratory are within the normal range. Imaging examination: Cervical MRI (February 24, 2016) showed mild thinning of the C6-7 level spinal cord with irregular abnormal signals, forward displacement of the posterior wall of the dural sac, and widening of the dorsal epidural space (Figure 1). No obvious abnormalities were found on the MRI of the head. Electrophysiological examination: Electromyography (February 25, 2016) showed neurogenic damage in both upper limbs, mainly chronic damage, involving bilateral C7-T1 innervated muscles, especially on the right side. The first consideration was damage to the anterior horn cells of the spinal cord (Figure 2). The clinical diagnosis is Hirayama disease. Vitamin B12 25 administered μ G
Objective To study the effect of two trunk control trainings on motor function recovery of stroke patients in sequela period. Methods A total of 42 patients were randomly divided into control group (N = 21) and observation group (N = 21). The control group was treated by traditional trunk control training, and the observation group was treated by trunk control training using suspension technology. Both groups all received other conventional rehabilitation treatment. All patients received Trunk Control Test (TCT), Functional Ambulation Category Scale (FAC), Berg Balance Scale (BBS) and 10 m Maximum Walking Speed (10 m MWS) before and 20 d after treatment. Results After two courses of treatment, the scores of TCT ( P = 0.000), FAC ( P = 0.000), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) were significantly improved in both groups. The scores of TCT ( P = 0.000), FAC ( P = 0.002), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) after treatment in observation group were all significantly higher than those in control group. Conclusions The method of trunk control training under suspension can effectively improve the motor function of stroke patients in sequela period. DOI: 10.3969/j.issn.1672-6731.2017.04.006
{"title":"Rehabilitation effect of trunk control training under suspension on motor function of stroke patients in sequela period","authors":"Xiaoyong Yan, Jianzhong Xiong, Sheng-wei Li, Yongxiang Zhou, Wenjing Wei","doi":"10.3969/cjcnn.v17i4.1577","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i4.1577","url":null,"abstract":"Objective To study the effect of two trunk control trainings on motor function recovery of stroke patients in sequela period. Methods A total of 42 patients were randomly divided into control group (N = 21) and observation group (N = 21). The control group was treated by traditional trunk control training, and the observation group was treated by trunk control training using suspension technology. Both groups all received other conventional rehabilitation treatment. All patients received Trunk Control Test (TCT), Functional Ambulation Category Scale (FAC), Berg Balance Scale (BBS) and 10 m Maximum Walking Speed (10 m MWS) before and 20 d after treatment. Results After two courses of treatment, the scores of TCT ( P = 0.000), FAC ( P = 0.000), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) were significantly improved in both groups. The scores of TCT ( P = 0.000), FAC ( P = 0.002), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) after treatment in observation group were all significantly higher than those in control group. Conclusions The method of trunk control training under suspension can effectively improve the motor function of stroke patients in sequela period. DOI: 10.3969/j.issn.1672-6731.2017.04.006","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"266-269"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44264519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-25DOI: 10.3969/cjcnn.v17i4.1581
Yi-rui Cao, Bo Wu, Jiayu Sun
Objective To analyze the correlation between tortuosity of extracranial internal carotid artery (EICA) and extracranial vertebral artery (EVA) and acute ischemic stroke, so as to discuss the causes of vascular tortuosity and the mechanism on inducing stroke. Methods This study included 103 patients with acute ischemic stroke and 103 patients without acute ischemic stroke whose manifestations were headache and dizziness. CTA was used to measure the tortuosity index (TI), deviation degree (DD), tortuosity degree (TD) and angular number (AN) of EICA and EVA. Pearson correlation analysis and Spearman rank correlation analysis were used to analyze the correlations of arterial tortuosity with risk factors for ischemic stroke and vascular morphology. Univariate and stepwise multivariate Logistic regression analysis were used to screen related risk factors for tortuosity of EICA and EVA. Results The stroke group had higher TI ( P = 0.000, 0.000), DD ( P = 0.000, 0.000), TD ( P = 0.002, 0.000) and AN ( P =0.019, 0.000) of EICA and EVA than those in control group. According to the site of infarction, the stroke group was divided into anterior circulation infarction (ACI) subgroup (N = 73) and posterior circulation infarction (PCI) subgroup (N = 30), and there was no significant difference in above-mentioned vascular morphological indexes between 2 subgroups ( P > 0.05, for all); in each subgroup, there was no significant difference between infarct side and non-infarct side of EICA, and between left and right EVA ( P > 0.05, for all). Nevertheless, the TI ( P = 0.000), DD ( P = 0.000) and TD ( P = 0.045) of EICA in ACI subgroup were higher than those in control group; TI ( P = 0.000), DD ( P = 0.000), TD ( P = 0.000) and AN ( P = 0.046) of EVA in PCI subgroup were higher than those in control group. In stroke group, correlation analysis revealed that TI of EICA was positively correlated with age, cervical artery atherosclerosis (CAS), EICA and EVA morphological indexes (except DD of EVA; P < 0.05, for all), but was negatively correlated with male ( r s = -0.253, P = 0.010); TI of EVA was positively correlated with age, hypertension, morphological indexes of EICA and EVA ( P < 0.05, for all), but negatively correlated with male ( r s =-0.276, P = 0.005). Univariate and stepwise multivariate Logistic regression analysis showed that female (EICA: OR = 1.458, 95% CI: 1.111-5.166, P = 0.016; EVA: OR = 9.092，95%CI: 1.294-63.872, P = 0.026) and age (EICA: O R = 1.050, 95%CI: 1.013-1.088， P = 0.007; EVA: OR = 1.084, 95%CI: 1.003-1.138, P = 0.001) were independent risk factors for tortuosity of EICA and EVA. Conclusions There are no significant differences between left and right side, anterior and posterior circulation on tortuosity distribution of patients with ischemic stroke. The EICA and EVA morphological indexes of stroke patients was significantly higher than that of non-stroke patients. Female and age are independent risk factors for tortuosity of EICA and
目的分析颅外颈内动脉(EICA)和颅外椎动脉(EVA)扭曲与急性缺血性脑卒中的相关性，探讨血管扭曲的原因及诱发脑卒中的机制。方法选取以头痛、头晕为临床表现的急性缺血性脑卒中患者103例和非急性缺血性脑卒中患者103例。采用CTA测量EICA和EVA的扭曲度指数(TI)、偏离度(DD)、扭曲度(TD)和角数(AN)。采用Pearson相关分析和Spearman秩相关分析分析动脉曲度与缺血性脑卒中危险因素及血管形态的相关性。采用单因素和逐步多因素Logistic回归分析筛选EICA和EVA扭曲的相关危险因素。结果脑卒中组EICA、EVA的TI (P = 0.000、0.000)、DD (P = 0.000、0.000)、TD (P = 0.002、0.000)、AN (P =0.019、0.000)均高于对照组。根据梗死部位将卒中组分为前循环梗死(ACI)亚组(N = 73)和后循环梗死(PCI)亚组(N = 30)，两亚组间上述血管形态学指标比较差异均无统计学意义(P < 0.05);各亚组EICA梗死侧与非梗死侧、左EVA与右EVA差异均无统计学意义(P < 0.05)。但ACI亚组EICA的TI (P = 0.000)、DD (P = 0.000)和TD (P = 0.045)均高于对照组;PCI亚组EVA的TI (P = 0.000)、DD (P = 0.000)、TD (P = 0.000)、AN (P = 0.046)均高于对照组。脑卒中组EICA TI与年龄、颈动脉粥样硬化(CAS)、EICA、EVA形态学指标均呈正相关(除EVA DD;P < 0.05)，但与男性呈负相关(r s = -0.253, P = 0.010);EVA的TI与年龄、高血压、EICA形态学指标和EVA呈正相关(P < 0.05)，与男性呈负相关(r s =-0.276, P = 0.005)。单因素和逐步多因素Logistic回归分析显示，女性(EICA: OR = 1.458, 95% CI: 1.111 ~ 5.166, P = 0.016;EVA: OR = 9.092,95%CI: 1.294 ~ 63.872, P = 0.026)与年龄(EICA: OR = 1.050, 95%CI: 1.013 ~ 1.088, P = 0.007;EVA: OR = 1.084, 95%CI: 1.003 ~ 1.138, P = 0.001)是EICA和EVA扭曲的独立危险因素。结论缺血性脑卒中患者左、右、前后循环曲度分布无明显差异。脑卒中患者的EICA和EVA形态学指标显著高于非脑卒中患者。女性和年龄是EICA和EVA扭曲的独立危险因素。DOI: 10.3969 / j.issn.1672-6731.2017.04.010
{"title":"Correlation analysis between tortuosity of extracranial internal carotid artery and extracranial vertebral artery and acute ischemic stroke","authors":"Yi-rui Cao, Bo Wu, Jiayu Sun","doi":"10.3969/cjcnn.v17i4.1581","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i4.1581","url":null,"abstract":"Objective To analyze the correlation between tortuosity of extracranial internal carotid artery (EICA) and extracranial vertebral artery (EVA) and acute ischemic stroke, so as to discuss the causes of vascular tortuosity and the mechanism on inducing stroke. Methods This study included 103 patients with acute ischemic stroke and 103 patients without acute ischemic stroke whose manifestations were headache and dizziness. CTA was used to measure the tortuosity index (TI), deviation degree (DD), tortuosity degree (TD) and angular number (AN) of EICA and EVA. Pearson correlation analysis and Spearman rank correlation analysis were used to analyze the correlations of arterial tortuosity with risk factors for ischemic stroke and vascular morphology. Univariate and stepwise multivariate Logistic regression analysis were used to screen related risk factors for tortuosity of EICA and EVA. Results The stroke group had higher TI ( P = 0.000, 0.000), DD ( P = 0.000, 0.000), TD ( P = 0.002, 0.000) and AN ( P =0.019, 0.000) of EICA and EVA than those in control group. According to the site of infarction, the stroke group was divided into anterior circulation infarction (ACI) subgroup (N = 73) and posterior circulation infarction (PCI) subgroup (N = 30), and there was no significant difference in above-mentioned vascular morphological indexes between 2 subgroups ( P > 0.05, for all); in each subgroup, there was no significant difference between infarct side and non-infarct side of EICA, and between left and right EVA ( P > 0.05, for all). Nevertheless, the TI ( P = 0.000), DD ( P = 0.000) and TD ( P = 0.045) of EICA in ACI subgroup were higher than those in control group; TI ( P = 0.000), DD ( P = 0.000), TD ( P = 0.000) and AN ( P = 0.046) of EVA in PCI subgroup were higher than those in control group. In stroke group, correlation analysis revealed that TI of EICA was positively correlated with age, cervical artery atherosclerosis (CAS), EICA and EVA morphological indexes (except DD of EVA; P < 0.05, for all), but was negatively correlated with male ( r s = -0.253, P = 0.010); TI of EVA was positively correlated with age, hypertension, morphological indexes of EICA and EVA ( P < 0.05, for all), but negatively correlated with male ( r s =-0.276, P = 0.005). Univariate and stepwise multivariate Logistic regression analysis showed that female (EICA: OR = 1.458, 95% CI: 1.111-5.166, P = 0.016; EVA: OR = 9.092，95%CI: 1.294-63.872, P = 0.026) and age (EICA: O R = 1.050, 95%CI: 1.013-1.088， P = 0.007; EVA: OR = 1.084, 95%CI: 1.003-1.138, P = 0.001) were independent risk factors for tortuosity of EICA and EVA. Conclusions There are no significant differences between left and right side, anterior and posterior circulation on tortuosity distribution of patients with ischemic stroke. The EICA and EVA morphological indexes of stroke patients was significantly higher than that of non-stroke patients. Female and age are independent risk factors for tortuosity of EICA and ","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"290-299"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44723345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-25DOI: 10.3969/CJCNN.V17I4.1582
Bei Huang, Huijuan Wu, Zhen-ying Qian, Jijun Wang, Zhong-xin Zhao
Transcranial magnetic stimulation (TMS) is a non-invasive and painless neuroelectrophysiological examination technology. TMS-motor evoked potential (TMS-MEP) is widely used to assess motor cortex excitability and conduction of descending corticobulbar tract and corticospinal tract. Recently, deeper understanding on principles of magnetic stimulation and diversification of stimulation coil and pattern has greatly expanded the application of TMS in clinical diagnosis. Moreover, MEP operation procedures are becoming more scientific and standardized. This paper reviews the progress of conventional diagnostic TMS pattern, several special stimulation patterns and the combined application of TMS, electroencephalograpy (EEG) and fMRI. DOI: 10.3969/j.issn.1672-6731.2017.04.011
{"title":"Research progress of diagnostic transcranial magnetic stimulation","authors":"Bei Huang, Huijuan Wu, Zhen-ying Qian, Jijun Wang, Zhong-xin Zhao","doi":"10.3969/CJCNN.V17I4.1582","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1582","url":null,"abstract":"Transcranial magnetic stimulation (TMS) is a non-invasive and painless neuroelectrophysiological examination technology. TMS-motor evoked potential (TMS-MEP) is widely used to assess motor cortex excitability and conduction of descending corticobulbar tract and corticospinal tract. Recently, deeper understanding on principles of magnetic stimulation and diversification of stimulation coil and pattern has greatly expanded the application of TMS in clinical diagnosis. Moreover, MEP operation procedures are becoming more scientific and standardized. This paper reviews the progress of conventional diagnostic TMS pattern, several special stimulation patterns and the combined application of TMS, electroencephalograpy (EEG) and fMRI. DOI: 10.3969/j.issn.1672-6731.2017.04.011","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45847324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-25DOI: 10.3969/CJCNN.V17I4.1580
Shu-xuan Huang, Feiqi Zhu, Z. Pei, Xu-hui Deng, Zhi Yang, Jin-hua Zhu, Chun-chun Chen, Wei-feng Lin
Objective To investigate the protective effect of berberine chloride on secondary damage (inflammation, oxidative damage and neuron loss) in bilateral thalami of traumatic brain injury (TBI) model mice. Methods Mice were randomly divided into 3 groups: control group (N = 6), TBI group (N = 6) and berberine group (N = 6). TBI model was established by a free-falling hitting device. In control group, mice were not given free-falling hitting. Mice in berberine group were given a gavage of berberine chloride [50 mg/（kg·d)] for 21 d, while mice in TBI group were given the same dosage of normal saline for 21 d. Immunohistochemistry was used to count the number of neurons or gliocytes positive for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), 8-hydroxy deoxyguanosine (8-OHdG) and neuronal nuclei (NeuN), the number of astrocytes positive for glial fibrillary acidic protein (GFAP) and the number of microglias positive for ionized calcium-binding adaptor molecule 1 (Iba1). Results The number of neurons or gliocytes positive for iNOS ( P = 0.015), COX-2 ( P = 0.022), 8-OHdG ( P = 0.000) and NeuN ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.024) and microglias positive for Iba1 ( P = 0.000) in TBI ipsilateral thalamus were significantly different among 3 groups. In TBI group, the number of neurons or gliocytes positive for iNOS ( P = 0.005), COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.011) and microglias positive for Iba1 ( P = 0.000) were significantly higher than those in control group, while the number of neurons positive for NeuN ( P = 0.000) was significantly lower than that in control group. In berberine group, the number of neurons or gliocytes positive for iNOS ( P = 0.031), COX-2 ( P = 0.024) and 8-OHdG ( P = 0.008), the number of astrocytes positive for GFAP ( P = 0.031) and microglias positive for Iba1 ( P = 0.012) were significantly lower than those in TBI group, while the number of neurons positive for 8-OHdG ( P = 0.014) and microglias positive for Iba1 ( P = 0.024) were significantly higher than those in control group. The number of neurons positive for NeuN in berberine group was significantly higher than that in TBI group ( P = 0.016), while lower than that in control group ( P = 0.027). Additionally, number of neurons or gliocytes positive for COX-2 ( P = 0.029) and 8-OHdG ( P = 0.000) in TBI contralateral thalamus were significantly different among 3 groups. The number of neurons or gliocytes positive for COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000) in TBI group was significantly higher than that in control group, while the number of neurons or gliocytes positive for COX-2 ( P = 0.047) and 8-OHdG ( P = 0.010) in berberine group was significantly lower than that in TBI group. The number of neurons positive for 8-OHdG in berberine group was significantly higher than that in control group ( P = 0.004). Conclusions TBI could cause secondary damage of bila
{"title":"Protective effect of berberine chloride on secondary damage of bilateral thalami in traumatic brain injury model mice","authors":"Shu-xuan Huang, Feiqi Zhu, Z. Pei, Xu-hui Deng, Zhi Yang, Jin-hua Zhu, Chun-chun Chen, Wei-feng Lin","doi":"10.3969/CJCNN.V17I4.1580","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1580","url":null,"abstract":"Objective To investigate the protective effect of berberine chloride on secondary damage (inflammation, oxidative damage and neuron loss) in bilateral thalami of traumatic brain injury (TBI) model mice. Methods Mice were randomly divided into 3 groups: control group (N = 6), TBI group (N = 6) and berberine group (N = 6). TBI model was established by a free-falling hitting device. In control group, mice were not given free-falling hitting. Mice in berberine group were given a gavage of berberine chloride [50 mg/（kg·d)] for 21 d, while mice in TBI group were given the same dosage of normal saline for 21 d. Immunohistochemistry was used to count the number of neurons or gliocytes positive for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), 8-hydroxy deoxyguanosine (8-OHdG) and neuronal nuclei (NeuN), the number of astrocytes positive for glial fibrillary acidic protein (GFAP) and the number of microglias positive for ionized calcium-binding adaptor molecule 1 (Iba1). Results The number of neurons or gliocytes positive for iNOS ( P = 0.015), COX-2 ( P = 0.022), 8-OHdG ( P = 0.000) and NeuN ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.024) and microglias positive for Iba1 ( P = 0.000) in TBI ipsilateral thalamus were significantly different among 3 groups. In TBI group, the number of neurons or gliocytes positive for iNOS ( P = 0.005), COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.011) and microglias positive for Iba1 ( P = 0.000) were significantly higher than those in control group, while the number of neurons positive for NeuN ( P = 0.000) was significantly lower than that in control group. In berberine group, the number of neurons or gliocytes positive for iNOS ( P = 0.031), COX-2 ( P = 0.024) and 8-OHdG ( P = 0.008), the number of astrocytes positive for GFAP ( P = 0.031) and microglias positive for Iba1 ( P = 0.012) were significantly lower than those in TBI group, while the number of neurons positive for 8-OHdG ( P = 0.014) and microglias positive for Iba1 ( P = 0.024) were significantly higher than those in control group. The number of neurons positive for NeuN in berberine group was significantly higher than that in TBI group ( P = 0.016), while lower than that in control group ( P = 0.027). Additionally, number of neurons or gliocytes positive for COX-2 ( P = 0.029) and 8-OHdG ( P = 0.000) in TBI contralateral thalamus were significantly different among 3 groups. The number of neurons or gliocytes positive for COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000) in TBI group was significantly higher than that in control group, while the number of neurons or gliocytes positive for COX-2 ( P = 0.047) and 8-OHdG ( P = 0.010) in berberine group was significantly lower than that in TBI group. The number of neurons positive for 8-OHdG in berberine group was significantly higher than that in control group ( P = 0.004). Conclusions TBI could cause secondary damage of bila","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"282-289"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42531161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：