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Introduction: This is a case of a 35-year-old man, diagnosed with type 1 diabetes mellitus (DM) at the age of 16 after hospitalization due to diabetic ketoacidosis (DKA) and positive glutamic acid decarboxylase (GAD) antibodies. His diabetes was never well controlled and there is a strong family history of diabetes and prediabetes as described. He asked to be checked for monogenic diabetes, so we conducted an exome panel for this condition. Surprisingly, the genetic testing was clearly positive for the heterozygote Glucokinase (GCK) gene, a highly pathogenic maturity-onset diabetes of the young (MODY) type 2. All family members were referred to complete exome panel, which is not yet complete. In the literature the author found a few similar case reports. The genetic defect in MODY2 diabetes is in the phosphorylation of glucose to glucose 6 phosphate which acts as a glucose sensor; this causes insulin secretion in higher glucose levels.

Introduction: Cognitive Processing Therapy (CPT) is one of only a few evidence based therapies that was developed and proven effective for the treatment of Post-Traumatic Stress Disorder (PTSD). Therapy can be administered in an individual or group format. Group CPT was offered in our clinic prior to the onset of the Iron Swords war. Among the participants was G., who was diagnosed with PTSD following an injury that occurred during his military service.

Aims: The aim of this report is to present group CPT through the experience of one participant who was diagnosed with PTSD due to a military injury and to discuss the potential utility of such a group to treat PTSD secondary to the Iron Swords war.

Background: G was referred to treatment due to decreased functioning and active symptoms of PTSD that persisted several years after his injury. Despite his reservations, he participated in most meetings of group therapy that was based on the CPT protocol.

Discussion: In this time of war where trauma is abundant, a group model based on a protocol that was developed specifically to treat PTSD may be useful. In the case presented, group based CPT partially improved PTSD symptoms in a participant with a military based injury. Since then our clinic continues to offer group based CPT therapy which was also provided to a population of survivors of the massacre that took place at the onset of the Iron Swords war.

Introduction: PLASTICS AND REFRACTION - EXPO - ISRAEL, MAY 28, 2024.

Introduction: In recent years, there has been a remarkable growth in the development and use of artificial intelligence tools in medicine based on large language models. This review will describe the main existing tools and their various applications for medical staff and patients. Despite its popularity, we will show that ChatGPT is not the only tool and that other tools are sometimes preferable. We will review research comparisons between different tools' effectiveness in various tasks. It will be shown that these tools lack specific performances, such as accuracy and reliability in providing information, understanding clinical context, and making diagnoses. The number of studies on these topics is small, and sometimes their presented results contradict each other. Additional quality research is needed to characterize and improve these tools and designate specific tools for different medical uses. Despite the many advantages and enormous potential inherent in these models, they should be used cautiously, as they only aid the treating physician and do not replace his knowledge, professional experience, and human judgment.

Introduction: Fumarate hydratase-deficient renal cell carcinoma (FHdRCC) is a rare and aggressive form of kidney cancer that presents significant therapeutic challenges. Due to its rarity, treatment decisions often rely on comprehensive literature reviews to identify potential therapeutic options. This article presents a case of a 37-year-old patient with metastatic FHdRCC who showed partial response to Nivolumab but experienced persistent lymphatic involvement and symptoms requiring ongoing intervention. The clinical team sought to evaluate alternative combination therapies through a literature review. Elicit, an AI-powered research assistant, was employed to structure the literature review process through an automated analysis of scientific papers. This case served as a test of Elicit's capabilities in synthesizing treatment options for rare cancers, compared to traditional research methodologies. The platform demonstrated significant limitations in its search capabilities due to restricted database access. However, it showed efficiency in analyzing provided papers and organizing clinical data by key categories. These findings suggest that while Elicit may serve as a helpful support tool for literature analysis, it is best used as a complement to traditional search methods, with careful verification of its output by clinical experts. Disclosures: Dolev Vaknin, Or Degany, Rotem Sisso-Avron, and Prof. Sharon Einav are employed by Medint Medical Intelligence, which conducted the literature review that served as the basis for this paper.

Introduction: Osgood-Schlatter's disease is a type of injury that occurs in children and adolescents due to overuse. The condition is characterized by pain, swelling, and inflammation in the region of the tibial tuberosity. Running and jumping intensively during periods of accelerated skeletal growth is associated with repeated and prolonged tensile forces that cause the disease. Initial inflammation turns into partial avulsion of cartilage from the tibial tuberosity, followed by the formation of ossicles in more severe cases. In most cases, OSD is managed conservatively by restricting strenuous exercise, prescribing analgesics, performing cryotherapy, engaging in physical therapy, and performing therapeutic exercises emphasizing strength and flexibility. In extreme cases displaying no improvement after skeletal maturity, surgical intervention is reserved as a last resort.

Introduction: "The Pain of Compassion Fatigue". Author: Dr. Eythan Hyam.

Introduction: Tennis elbow (lateral epicondylitis) is characterized by pain at the origin of the extensor carpi radialis brevis (ERCB) muscle from the lateral epicondyle of the humerus. A connection was found between tennis elbow and repetitive load in this area. In patients who suffer from elbow pain, tennis elbow is the most common cause, affecting 1-3% of the adult population each year. The diagnosis of tennis elbow is mainly clinical, based on medical history and physical examination. There are several possible treatments ranging from anti-inflammatory drugs and physiotherapy to various local injections (steroids, hyaluronic acid, etc.) and surgical treatment with debridement or release of the ECRB.

Introduction: Congenital Toxoplasmosis, What is Important for Israeli Doctors to Know?

Introduction: SPONTANEOUS RUPTURE OF A RENAL ANGIOMYOLIPOMA.