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Judicial access to medicines for rare diseases: characteristics of lawsuits against the Federal Government. 通过司法途径获得罕见病药品:针对联邦政府的诉讼的特点。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-01 Epub Date: 2025-07-30 DOI: 10.1590/1413-81232026311.14312025
Vera Lúcia Edais Pepe, Michelly Ribeiro Baptista, Miriam Ventura, Marina Fajardo V M Pompílio da Hora, Nathália Rodrigues Alvarez, Gabriela Suarez Pinto, Raulino Sabino da Silva, Thaís Jeronimo Vidal

Rare diseases are an important cause of infant mortality, yet their care presents many challenges. Legal claims have enabled access to medicines, but there are concerns about interference in health policy and patient safety. The present study analyzed 912 lawsuits, involving 23 medicines for 18 rare diseases between 2008 and 2022. Most plaintiffs were women and children, aged 0 to 5 years, residing in São Paulo and Minas Gerais. Legal aid was commonly granted, and 36 deaths were reported. The lawsuits originated from the Federal District, with limited use of alternative resolution methods. Private attorneys and prescriptions from private health services predominated. Court decisions were predominantly favorable to the plaintiffs, but only 4.2% of the actions indicated the inclusion of claimants in the Unified Health System (SUS). Despite Brazil's high rate of health litigation, some medicines involved in these lawsuits lacked strong evidence of efficacy and safety. Monitoring medicine use in this context is crucial to support future decisions. It is essential to develop innovative policies and coordination among different sectors to ensure effective and comprehensive care for individuals with rare diseases.

罕见病是婴儿死亡的一个重要原因,但对其护理提出了许多挑战。法律要求使人们能够获得药品,但人们担心卫生政策和患者安全受到干扰。本研究分析了2008年至2022年期间的912起诉讼,涉及18种罕见疾病的23种药物。大多数原告是居住在圣保罗和米纳斯吉拉斯州的0至5岁的妇女和儿童。通常提供法律援助,据报有36人死亡。这些诉讼源自联邦区,对替代解决方法的使用有限。私人律师和私人医疗机构的处方占主导地位。法院的判决主要对原告有利,但只有4.2%的诉讼表明原告被纳入统一医疗系统(SUS)。尽管巴西的健康诉讼率很高,但这些诉讼中涉及的一些药物缺乏有效性和安全性的有力证据。在这种情况下监测药物使用情况对于支持未来的决策至关重要。必须制定创新政策并在不同部门之间进行协调,以确保罕见病患者得到有效和全面的护理。
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引用次数: 0
Syphilis and penicillin shortage: surveillance, pharmaceutical services and federal response (2014-2023). 梅毒和青霉素短缺:监测、药品服务和联邦应对(2014-2023年)。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-01 Epub Date: 2025-07-30 DOI: 10.1590/1413-81232026311.14022025
Esdras Daniel Dos Santos Pereira, Vera Lucia Luiza

Syphilis remains a significant sexually transmitted infection in Brazil, with benzathine penicillin (BPG) as the first-line treatment. In 2014, the country faced a global penicillin shortage, prompting a coordinated federal response, especially in light of rising congenital syphilis cases. This study conducted a documentary analysis of 37 official documents (price registration minutes, technical notes, ordinances, and decrees) to characterize strategies for procurement, price negotiation, and national and international cooperation. The analysis revealed a progressive increase in public procurement of penicillin after 2014 and growing integration between pharmaceutical services, surveillance, and care within the Brazilian Unified Health System (SUS). Federal pharmaceutical services and medicines management was central in overcoming shortages, ensuring BPG supply, and articulating surveillance and comprehensive care. The findings highlight pharmaceutical services as a structural component of the Brazilian response to syphilis, impacting case detection, care, and epidemiological surveillance.

在巴西,梅毒仍然是一种重要的性传播感染,苄星青霉素(BPG)是一线治疗药物。2014年,该国面临全球青霉素短缺,促使联邦政府采取协调一致的应对措施,特别是考虑到先天性梅毒病例不断上升。这项研究对37份官方文件(价格登记纪要、技术说明、条例和法令)进行了文献分析,以确定采购、价格谈判以及国内和国际合作的战略特征。分析显示,2014年之后,青霉素的公共采购逐步增加,巴西统一卫生系统(SUS)内的药品服务、监测和护理之间的整合日益加强。联邦医药服务和药品管理在克服短缺、确保BPG供应以及明确监督和全面护理方面发挥了核心作用。研究结果强调,医药服务是巴西梅毒应对工作的一个结构性组成部分,影响着病例发现、护理和流行病学监测。
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引用次数: 0
The pharmaceutical workforce in the SUS: Trends and alerts over the last decade (2014-2023). 美国的制药劳动力:过去十年的趋势和警告(2014-2023)。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-01 Epub Date: 2025-07-30 DOI: 10.1590/1413-81232026311.14502025
Marselle Nobre de Carvalho, Bruna Ruzza Monteguti, Emilia Baierle Faraco, Silvana Nair Leite

The pharmaceutical workforce in the Unified Health System is responsible for the actions that materialize the National Pharmaceutical Policy from management to care. This study sets out to analyze the dynamics of the pharmaceutical workforce in the SUS over the last 10 years, starting from 2013, a period of rapid growth. We analyzed data recorded in the CNES and IBGE, shown in terms of growth and population rates. Between 2014 and 2023, the total pharmacist workforce in the facilities that serve the SUS in Brazil grew by 36%, and in PHC settings by 47%; 91.96% of pharmacists are not linked to any team. The types of professional relationships that have shown the most growth in the last ten years have been those characterized as "unprotected", such as scholarships and internships, or other types of employment that do not guarantee labor rights. The highest population rates were in the southern states (49.2/100,000), and the lowest in the Northeast and Midwest (32/100,000). The slower growth over the last decade, the disparities between states and regions, and the types of employment contracts all point to the need for continuous work by professional bodies and social participation to defend the pharmaceutical workforce in order to advance the PNAF.

统一卫生系统中的药学工作人员负责从管理到护理实现国家药学政策的行动。本研究旨在分析过去10年(从2013年开始的快速增长时期)美国制药劳动力的动态。我们分析了CNES和IBGE记录的数据,显示了增长率和人口增长率。2014年至2023年间,巴西为SUS服务的机构的药剂师总人数增长了36%,初级保健机构的药剂师总人数增长了47%;91.96%的药师未加入任何团队。在过去十年中增长最快的职业关系类型是那些被定性为“不受保护”的,例如奖学金和实习,或其他不保障劳工权利的就业类型。人口比例最高的是南部各州(49.2/10万),最低的是东北部和中西部(32/10万)。过去十年的缓慢增长,州和地区之间的差异,以及雇佣合同的类型都表明,为了推进PNAF,需要专业机构和社会参与的持续工作来保护制药劳动力。
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引用次数: 0
National Pharmaceutical Policy and the Health Economic-Industrial Complex: influences and invisibilities. 国家医药政策与卫生经济产业综合体:影响与隐蔽性。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-01 Epub Date: 2025-07-28 DOI: 10.1590/1413-81232026311.14362025
Norberto Rech, Jorge Antonio Zepeda Bermudez, Jorge Carlos Santos da Costa, Mareni Rocha Farias

In 2024, we celebrate the twentieth anniversary of the National Pharmaceutical Policy (PNAF), which involves actions to promote, protect, and restore health, with the population's access to medicines and their rational use as an essential part of its principles. This intersectoral policy is strategic for including SUS demands in the agenda of other sectors with impacts on the field of Health, including those that are part of the Health Economic-Industrial Complex (CEIS). Given its characteristics, this study aimed to identify the PNAF's influence in CEIS-related public policies from 2004 to 2024 to improve such policies. We adopted the model developed by Walt and Gilson (1994) to analyze public policies, identifying contexts proposed by Araújo Júnior and Maciel Filho (2001) and the typology of policies proposed by Walt (1994). The results showed the PNAF's principles and strategic lines in 17 CEIS-and-Health-related sectoral policies over 20 years, with notable invisibilities from 2017 to April 2023.

2024年,我们将庆祝《国家药品政策》制定20周年,该政策涉及促进、保护和恢复健康的行动,并将人民获得药品和合理使用药品作为其原则的重要组成部分。这一部门间政策具有战略意义,可将单一保健系统的需求纳入对卫生领域有影响的其他部门的议程,包括卫生经济-工业综合体的部门。鉴于PNAF的特点,本研究旨在确定2004 - 2024年PNAF在ceis相关公共政策中的影响,以完善这些政策。我们采用Walt和Gilson(1994)开发的模型来分析公共政策,确定Araújo Júnior和Maciel Filho(2001)提出的语境和Walt(1994)提出的政策类型。结果显示了20年来PNAF在17项ceis和健康相关部门政策中的原则和战略路线,从2017年到2023年4月,这些政策明显不可见。
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引用次数: 0
[Effort-reward imbalance at work and satisfaction with life in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)]. [巴西成人健康纵向研究(ELSA-Brasil)中工作中的努力-回报不平衡和生活满意度]。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2024-10-07 DOI: 10.1590/1413-812320253012.06332024
Ivonice Meire do Carmo Gentil, Karina Araújo Pinto, Maria Conceição Chagas de Almeida, Yukari Figueiroa Mise, Rosane Harter Griep, Sheila Maria Alvim de Matos, Maria de Jesus Mendes da Fonseca, Milena Maria Cordeiro de Almeida

The scope of this study was to analyze the association between effort-reward imbalance (ERI) at work and satisfaction with life among Brazilian public servants. It involved a cross-sectional study with 9,199 active participants in the second stage (2012-2014) of ELSA-Brasil. Sex-stratified analyses were performed using logistic regression at a 5% significance level. Women and men who reported ERI at work were more likely to report dissatisfaction with life (OR = 2.38; 95%CI: 1.93-2.93 and OR = 2.01; 95%CI: 1.68-2.39, respectively) compared to those without ERI. Among women, those in higher/teaching positions revealed a stronger association between ERI and dissatisfaction with life (OR = 2.77; 95%CI: 1.90-4.04) compared to those in support/medium-level positions (OR = 1.71; 95%CI: 1.38-2.12). Occupational stressors, as measured by ERI, were associated with dissatisfaction with life among public servants of both sexes. Functional level acted as an effect modifier in the association between ERI and satisfaction with life among women, potentially reflecting the increased educational and professional requirements women face to access and remain in the labor market as part of efforts to mitigate gender inequality.

本研究的范围是分析巴西公务员工作中的努力-回报不平衡(ERI)与生活满意度之间的关系。它涉及一项横断面研究,在ELSA-Brasil的第二阶段(2012-2014)有9199名活跃参与者。性别分层分析采用逻辑回归,显著性水平为5%。与没有ERI的女性和男性相比,在工作中报告ERI的女性和男性更有可能报告对生活的不满(OR = 2.38; 95%CI: 1.93-2.93和OR = 2.01; 95%CI: 1.68-2.39)。在女性中,与处于支持/中级职位的女性(OR = 1.71; 95%CI: 1.38-2.12)相比,处于较高/教学职位的女性(OR = 2.77; 95%CI: 1.90-4.04)显示出更强的ERI与生活不满之间的关联(OR = 2.77; 95%CI: 1.90-4.04)。根据ERI的测量,职业压力因素与男女公务员对生活的不满有关。在ERI和妇女生活满意度之间的关系中,功能水平起到了调节作用,这可能反映了作为减轻性别不平等努力的一部分,妇女进入和留在劳动力市场所面临的教育和专业要求的增加。
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引用次数: 0
[Convergences between promotion of health, public health education, educommunication and health literacy]. [促进健康、公共卫生教育、教育传播和卫生素养之间的趋同]。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2024-10-18 DOI: 10.1590/1413-812320253012.05812024
Marco Akerman, Adriana Miranda de Castro, Cristina Almeida Santos, Pedro José Santos Carneiro Cruz, Noelia Rodrigues Pereira Rego, Frederico Peres

In Brazil, studies and practices around the concept of health literacy are recent and linked to the application of internationally validated instruments. From this perspective, a more conservative emphasis on the adoption of health literacy practices can be observed. This article explores possibilities for a Brazilian model of health literacy, considering the marked presence of the Brazilian community in public health in the promotion of health, popular education and educommunication, by linking timelines of these four areas of knowledge and practices. Having established these timelines, it seeks to highlight the main national and international historical, academic and political milestones, of each of these areas, over a specific period (1970-2023), against the backdrop of four political scenarios: "military governments," "redemocratization and neoliberalism," "progressive governments" and "conservatism." Based on the identification of significant national and international milestones and the confluence between the fields of health promotion, popular health education, and educommunication, the possibility of a Brazilian model is postulated for promoting health literacy.

在巴西,围绕卫生知识普及概念的研究和实践是最近才开展的,并与国际认可的文书的应用有关。从这个角度来看,可以观察到更保守地强调采用卫生知识普及做法。本文探讨了巴西卫生知识普及模式的可能性,考虑到巴西社区在公共卫生领域的显著存在,通过将这四个知识和实践领域的时间表联系起来,促进健康、普及教育和教育交流。在建立了这些时间表之后,它试图在四种政治情景的背景下,在特定时期(1970-2023年)突出这些领域的主要国家和国际历史、学术和政治里程碑:“军政府”、“再民主化和新自由主义”、“进步政府”和“保守主义”。根据对国家和国际重要里程碑的确定,以及健康促进、大众健康教育和教育传播领域之间的融合,假设巴西模式有可能促进健康素养。
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引用次数: 0
The structure of Brazilian PHC units: what has changed between 2012 and 2024? 巴西初级保健单位的结构:2012年至2024年间发生了什么变化?
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-08-13 DOI: 10.1590/1413-812320253012.08792025
Aylene Bousquat, Simone Schenkman, Patty Fidelis de Almeida, Paulo Henrique Dos Santos Mota, Ligia Giovanella

The structural typology of PHC units was drawn up based on the results of the 2024 National Census of PHC units, and the results were compared with those of 2012. Types of teams, diversity of professionals, shifts, available services, and facilities and supplies were used as the sub-dimension categories. A reference standard was set for each sub-dimension and a standardized score was calculated, with 1 being the best. Of the 44,938 PHC units that took part in the Census, 43,209 presented complete information on the variables and were analyzed. The final average score was 0.878, which proved to be 20% higher than in 2012. The sub-dimension with the worst score was "types of teams", and the best was "shifts". The units were grouped according to their final score from best to worst: A, B, C, D, E. All regions increased the percentage of PHC units in groups A and B, especially the North and Northeast. Type A was observed in 21.3% of the PHC units, a 4.4-fold increase, when compared to 2012. Advances in infrastructure conditions, shifts, and the increased presence of doctors indicate the effects of policies aimed at expanding access to PHC. However, essential components for comprehensive PHC still deserve attention, such as the presence of a sufficient number of Community Health Workers (CHWs), universal dispensing of medicines, and equalization between oral health teams and family health strategy (FHS) teams.

根据2024年全国初级保健单位普查结果编制初级保健单位结构类型,并与2012年进行比较。团队类型、专业人员多样性、轮班、可用服务以及设施和用品被用作子维度类别。为每个子维度设定参考标准,并计算标准化得分,以1分为最佳。在参加普查的44,938个初级保健单位中,43,209个单位提供了关于变量的完整信息并进行了分析。最终平均得分为0.878,比2012年提高了20%。得分最低的子维度是“团队类型”,得分最高的子维度是“班次”。根据最终得分从好到坏进行分组:A、B、C、D、e。所有地区都增加了A和B组的初级保健单位百分比,特别是北部和东北部。与2012年相比,21.3%的初级保健单位出现了A型,增加了4.4倍。基础设施条件的改善、轮班和医生人数的增加表明,旨在扩大初级保健服务的政策产生了效果。然而,全面初级保健的基本组成部分仍然值得关注,例如有足够数量的社区卫生工作者(chw)、普遍分配药物以及口腔卫生小组和家庭卫生战略(FHS)小组之间的均衡。
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引用次数: 0
Prevalence of chronic diseases and factors associated with multimorbidity in the Brazilian Amazon: a cross-sectional population-based study, 2019. 巴西亚马逊地区慢性病患病率和与多病相关的因素:一项基于人群的横断面研究,2019年。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2024-10-09 DOI: 10.1590/1413-812320253012.06232024
Gustavo Magno Baldin Tiguman, Marcus Tolentino Silva, Bruno Pereira Nunes, Taís Freire Galvão

This study aimed to assess the prevalence of multimorbidity and associated factors in Manaus, Brazil. A cross-sectional population-based survey was conducted in 2019 using probabilistic sampling. Multimorbidity was defined as two or more self-reported chronic diseases. Multimorbidity treatment was considered if participants received treatment for all their conditions. Limitations in daily activities were assessed using a 5-point Likert scale. Poisson regression was applied to estimate prevalence ratios (PR) of multimorbidity with 95% confidence intervals (95%CI). Out of 2,321 participants, 30.6% (95%CI 28.7-32.4%) had multimorbidity (mean: 2.99 ± 1.27 conditions), and 28.8% (95%CI 25.3-32.0%) of them were treated for all diseases. Back pain, hypertension, and hypercholesterolemia were the most common conditions, while mental disorders, renal disease, and other less frequent illnesses were most markedly associated with severe limitations in daily activities. Multimorbidity was higher in women (PR =1.46; 95%CI 1.28-1.66), older people (p < 0.001), and retired individuals (PR = 1.41; 95%CI 1.13-1.75). Nearly 30% of the population of Manaus live with multimorbidity, which is associated with socioeconomic determinants; among them, approximately one-quarter received multimorbidity treatment.

本研究旨在评估巴西马瑙斯多病患病率及相关因素。2019年采用概率抽样进行了横断面人口调查。多病被定义为两种或两种以上自我报告的慢性疾病。如果参与者接受了所有条件的治疗,则考虑多病治疗。使用5分李克特量表评估日常活动的局限性。用泊松回归估计多病患病率(PR),置信区间为95%。在2321名参与者中,30.6% (95%CI 28.7-32.4%)患有多种疾病(平均:2.99±1.27种疾病),28.8% (95%CI 25.3-32.0%)的患者接受了所有疾病的治疗。背痛、高血压和高胆固醇血症是最常见的疾病,而精神障碍、肾脏疾病和其他不常见的疾病与严重的日常活动限制最显著相关。女性(PR =1.46; 95%CI 1.28-1.66)、老年人(p < 0.001)和退休人员(PR = 1.41; 95%CI 1.13-1.75)的多重发病率较高。玛瑙斯近30%的人口患有多种疾病,这与社会经济决定因素有关;其中,约四分之一接受了多病治疗。
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引用次数: 0
Prevalence of lifestyle habits following the use of integrative and complementary practices in Brazil's adult population: National Health Survey 2019. 巴西成年人采用综合和补充做法后生活习惯的流行程度:2019年全国健康调查。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2024-10-24 DOI: 10.1590/1413-812320253012.02712024
Mário Círio Nogueira, Larissa Valdier Cerqueira, Sarah Rachid Ozório, Iasmin Gomes Rodrigues

Integrative and complementary practices (ICPs) comprise complex medical systems and therapeutic resources that seek to stimulate natural disease prevention and health recovery mechanisms by promoting changes in lifestyle habits. The aim is to investigate the association between the use of ICPs and the prevalence of healthy eating habits in Brazil's population. This cross-sectional study used data on adult and older adult participants in Brazil's 2019 National Health Survey. Prevalence of habits was estimated by categories of ICP use, together with prevalence ratios adjusted by sociodemographic characteristics and chronic disease, using Poisson regression models with robust variance and 95% confidence intervals. ICP use was 5.5% prevalent. Interviewees who used some ICP during the period, returned a higher prevalence of regular consumption of fruits and vegetables and a lower prevalence of consumption of soft drinks, ultra-processed foods and beans. ICP users reported a higher prevalence of healthy eating habits, which is consistent with the approach the practices foster. Expanding access to ICPs can contribute to a healthier lifestyle.

综合和补充实践(ICPs)包括复杂的医疗系统和治疗资源,旨在通过促进生活习惯的改变来刺激自然疾病预防和健康恢复机制。目的是调查ICPs的使用与巴西人口健康饮食习惯的流行之间的关系。这项横断面研究使用了巴西2019年全国健康调查中成年人和老年人参与者的数据。使用具有稳健方差和95%置信区间的泊松回归模型,通过ICP使用类别以及经社会人口学特征和慢性疾病调整的患病率来估计习惯的流行程度。ICP使用率5.5%。在此期间使用了一些ICP的受访者表示,经常食用水果和蔬菜的比例较高,而软饮料、超加工食品和豆类的比例较低。国际比较方案的使用者报告说,健康的饮食习惯更为普遍,这与国际比较方案所提倡的做法相一致。扩大获得icp的机会有助于形成更健康的生活方式。
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引用次数: 0
Mapping of underreporting of interpersonal violence based on the occurrence of homicides in Brazilian municipalities, 2016-2018. 基于2016-2018年巴西城市杀人事件的人际暴力漏报地图。
IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-05-16 DOI: 10.1590/1413-812320253012.08432024
Adauto Marins Soares Filho, Cintia Honório Vasconcelos, Nádia Machado de Vasconcelos, Cheila Marina de Lima, Maria de Fátima Marinho de Souza, Isabella Vitral Pinto, Letícia de Oliveira Cardoso, Deborah Carvalho Malta

Identify municipalities with underreporting of interpersonal violence based on homicide in Brazil, 2016 to 2018. Ecological study with rate on violence from the Notifiable Diseases Information System and homicide estimates from the Global Burden of Disease concerning < 20 years, women of 20 to 59 years, ≥ 60 years and the total of these subgroups. Bivariate Local Moran identified clusters of critical areas of low reporting rates and high homicide rates (p < 0.05). Municipalities in the North, Northeast, and Midwest of Brazil represented 29% of all reports of violence and 58% of homicides. The majority of these municipalities were concentrated in low reporting rates (≤ 0.8/10,000) and high homicide rates (≥ 13.7/100,000); and 31.4% of municipalities with high homicide rate reported zero cases. Reports of violence and homicide rates showed a negative spatial correlation (I<20 = -0.083; Iwomen20-59 = -0.023; I≥60 = -0.086; Itotal = -0.085), showing that nearby places have inverse values. Critical municipalities for underreporting of violence reach 16% of < 20 years, 12% of women, 23% of the elderly, and 18% in total. The low reporting in seriously violent areas provides evidence of underreporting. The findings can provide management with tools for initiatives to improve violence surveillance and access to the protection network.

确定2016年至2018年巴西根据凶杀案少报人际暴力的城市。使用来自法定疾病信息系统的暴力率和来自全球疾病负担的凶杀估计数据进行生态学研究,涉及年龄< 20岁、20至59岁、≥60岁的妇女以及这些亚组的总数。双变量本地Moran确定了低报告率和高凶杀率的关键区域集群(p < 0.05)。巴西北部、东北部和中西部的城市占所有暴力报告的29%,占凶杀报告的58%。这些城市大多集中在低报告率(≤0.8/10,000)和高凶杀率(≥13.7/100,000)的地区;31.4%的高谋杀率城市报告零案件。报告显示暴力和凶杀率呈负空间相关性(1)
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