Pub Date : 2009-04-05DOI: 10.3760/CMA.J.ISSN.1673-4904.2009.10.010
Jian-ping Zhou, Yuqing Shen, Y. Kui, Wang Chen, Yuqi Qiu, Wan-xiang Wang, Jiangrong Deng
Objective To investigate the corelation between platelet activating factor acetylhydrolase (PAF-AH) genetic polymorphism and ischemic stroke. Methods The plasma PAF-AH genotype was determined in 205 patients with iachemic stroke and 114 normal subjects by the polymerase chain reaction. The levels of plasma platelet activating factor (PAF), platelet α-granule membrane glycoprotein-140(GMP-140), β-thromboglobulin (β-TG) and the levels of platelet factor 4 (PF4) were analyzed. Results The prevalence of the mutation genotype and plasma PAF, GMP-140, β-TG and PF4 in the patients with isehemic stroke [42.44%,(91.08 ± 39.10) ng/L, (36.46 ± 13.10) μg/L, (41.75 ± 11.18) μg/L, (29.05 ± 9.16) g/L, respectively] were significantly higher than those in the controls[21.05%,(64.30 ± 18.81) ng/L, (18.27 ± 7.68) μg/L, (30.94 ± 8.47) μg/L, (18.75 ± 6.06) μg/L](P< 0.01). The levels of plasma PAF, GMP-140 were significantly higher in mutation genotype patients than those in the normal genotype patients (P < 0.01). Conclusions The activation function of platelet in the acute phase of patients with ischemic stroke increases, and it is associated with genetic polymorphism of PAF-AH. The PAF-AH gene mutation may be a novel genetic marker for high risk of ischemic stroke. Key words: Cerebrovascular anident; Platelet activation; 1-Alkyl-2-acetylglycerophospho-choline esterase; Gene polymorphism
{"title":"Relationship between platelet activating factor acetylhydrolase genetic polymorphism and platelet activation and prognosis in patients with ischemic stroke","authors":"Jian-ping Zhou, Yuqing Shen, Y. Kui, Wang Chen, Yuqi Qiu, Wan-xiang Wang, Jiangrong Deng","doi":"10.3760/CMA.J.ISSN.1673-4904.2009.10.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2009.10.010","url":null,"abstract":"Objective To investigate the corelation between platelet activating factor acetylhydrolase (PAF-AH) genetic polymorphism and ischemic stroke. Methods The plasma PAF-AH genotype was determined in 205 patients with iachemic stroke and 114 normal subjects by the polymerase chain reaction. The levels of plasma platelet activating factor (PAF), platelet α-granule membrane glycoprotein-140(GMP-140), β-thromboglobulin (β-TG) and the levels of platelet factor 4 (PF4) were analyzed. Results The prevalence of the mutation genotype and plasma PAF, GMP-140, β-TG and PF4 in the patients with isehemic stroke [42.44%,(91.08 ± 39.10) ng/L, (36.46 ± 13.10) μg/L, (41.75 ± 11.18) μg/L, (29.05 ± 9.16) g/L, respectively] were significantly higher than those in the controls[21.05%,(64.30 ± 18.81) ng/L, (18.27 ± 7.68) μg/L, (30.94 ± 8.47) μg/L, (18.75 ± 6.06) μg/L](P< 0.01). The levels of plasma PAF, GMP-140 were significantly higher in mutation genotype patients than those in the normal genotype patients (P < 0.01). Conclusions The activation function of platelet in the acute phase of patients with ischemic stroke increases, and it is associated with genetic polymorphism of PAF-AH. The PAF-AH gene mutation may be a novel genetic marker for high risk of ischemic stroke. \u0000 \u0000Key words: \u0000Cerebrovascular anident; Platelet activation; 1-Alkyl-2-acetylglycerophospho-choline esterase; Gene polymorphism","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-09-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2008.26.002
Chun-sheng Li, Zhongya Yan, Lu Zhong, Wang Yijun, Lei Hong, Zhengyan Zhu, Sun Yun, Zheng Li, Guangcun Cheng
Objective To summarize the susceptible factors and the experience of the surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endecarditis.Methods From January 2000 to March 2008,30 cases with raptured aneurysm of the sinus of Valsalva were admitted, clinical data of 10 cases combined with infective endocarditis were retrospectively reviewed.Nine cases underwent the surgical treatment,including 6 cases accepted aortic valve replacement (AVR).Results Nine eases underwent the surgical treatment followed up for 2 months to 8 years,cardiac function of the survivors recovered to Class Ⅰ-Ⅱ in NYHA,7 cases were Ⅰ grade,2 cases were Ⅱ grade.One case was dead for MSOF not underwent the surgical treatment.Conclusions Associated with ventricular septal defect is one of the susceptible factors.Following diagnosis of ruptured aneurysm of sinus of Valsalva combined with infective endocarditis,sufficiently and validly antibiotic and surgical treatment should be pedormed as quickly as possible,and AVR to the moderate and severe aortic insufficiency. Key words: Sinus of Valsalva; Aneurysm,ruptured; Surgical procedures,operative; Endocarditis,bacterial
{"title":"Surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endocarditis","authors":"Chun-sheng Li, Zhongya Yan, Lu Zhong, Wang Yijun, Lei Hong, Zhengyan Zhu, Sun Yun, Zheng Li, Guangcun Cheng","doi":"10.3760/CMA.J.ISSN.1673-4904.2008.26.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2008.26.002","url":null,"abstract":"Objective To summarize the susceptible factors and the experience of the surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endecarditis.Methods From January 2000 to March 2008,30 cases with raptured aneurysm of the sinus of Valsalva were admitted, clinical data of 10 cases combined with infective endocarditis were retrospectively reviewed.Nine cases underwent the surgical treatment,including 6 cases accepted aortic valve replacement (AVR).Results Nine eases underwent the surgical treatment followed up for 2 months to 8 years,cardiac function of the survivors recovered to Class Ⅰ-Ⅱ in NYHA,7 cases were Ⅰ grade,2 cases were Ⅱ grade.One case was dead for MSOF not underwent the surgical treatment.Conclusions Associated with ventricular septal defect is one of the susceptible factors.Following diagnosis of ruptured aneurysm of sinus of Valsalva combined with infective endocarditis,sufficiently and validly antibiotic and surgical treatment should be pedormed as quickly as possible,and AVR to the moderate and severe aortic insufficiency. \u0000 \u0000Key words: \u0000Sinus of Valsalva; Aneurysm,ruptured; Surgical procedures,operative; Endocarditis,bacterial","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91394271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-03-05DOI: 10.3760/CMA.J.ISSN.1673-4904.2006.18.001
田大宇, 胡祥, 袁波
Objective To investigate the principle of lymph nodes metastasis (LNM) in early gastric carcinoma (EGC),and try to provide theoretical basis for individualized treatment. Methods One hundredand one patients were operated upon due to EGC, all clinicopathologic data were analyzed retrospectively. Results LNM was detected in 16 cases with lesion in lower stomach, the incidence of LNM was 15.8%. LNM correlated with depth of infiltration, tumor size and pathological type. The rate of LNM was 27.9% in SM2 ,significantly higher than that in M(2.8%) and SM(13.6%),P0.05.The incidence increased along with the increment of tumor size, no LNM was found in minute gastric cancer (MGC),5.0% in small gastric cancer(SGC),14.8% in patients with 1.1-2.0 cm lesion in diameter and 27.5% in greater than 2.0 cm (P0.05).Well-differentiated EGC without LNM, while the risk was 17.2%,19.6% for moderate- and poor- differentiated respectively. The research showed that, in levelⅠ tier lymph nodes (LN),the risk of No.3 LN involvement reached up to 50.0%, followed by No.6(37.5%), No.4(31.3%) and No.5(12.5%).In levelⅡ, the risk decreased gradually by 25.0%,12.5%,6.3% for No.7,8 a,9 LN respectively. In our series, M and SM1 involved level I tier LN, but levelⅡ tier LN involvement obviously increased in SM2.MGC without LNM, SGC involved level I tier LN only. Nevertheless the rate of levelⅡ tier LN involvement rose in patients with lesion greater than 1.1 cm in diameter. As the same that, no LNM in well-differentiated cancer, the risk of levelⅡ increased accompanying the worsening of differentiation. Conclusions The cognition to principle of LNM, especially the EGC in lower stomach, contribute to individualized surgery therapy and offer theoretical support for microinvasive operation.
{"title":"Clinical analysis of early gastric carcinoma in 101 patients","authors":"田大宇, 胡祥, 袁波","doi":"10.3760/CMA.J.ISSN.1673-4904.2006.18.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2006.18.001","url":null,"abstract":"Objective To investigate the principle of lymph nodes metastasis (LNM) in early gastric carcinoma (EGC),and try to provide theoretical basis for individualized treatment. Methods One hundredand one patients were operated upon due to EGC, all clinicopathologic data were analyzed retrospectively. Results LNM was detected in 16 cases with lesion in lower stomach, the incidence of LNM was 15.8%. LNM correlated with depth of infiltration, tumor size and pathological type. The rate of LNM was 27.9% in SM2 ,significantly higher than that in M(2.8%) and SM(13.6%),P0.05.The incidence increased along with the increment of tumor size, no LNM was found in minute gastric cancer (MGC),5.0% in small gastric cancer(SGC),14.8% in patients with 1.1-2.0 cm lesion in diameter and 27.5% in greater than 2.0 cm (P0.05).Well-differentiated EGC without LNM, while the risk was 17.2%,19.6% for moderate- and poor- differentiated respectively. The research showed that, in levelⅠ tier lymph nodes (LN),the risk of No.3 LN involvement reached up to 50.0%, followed by No.6(37.5%), No.4(31.3%) and No.5(12.5%).In levelⅡ, the risk decreased gradually by 25.0%,12.5%,6.3% for No.7,8 a,9 LN respectively. In our series, M and SM1 involved level I tier LN, but levelⅡ tier LN involvement obviously increased in SM2.MGC without LNM, SGC involved level I tier LN only. Nevertheless the rate of levelⅡ tier LN involvement rose in patients with lesion greater than 1.1 cm in diameter. As the same that, no LNM in well-differentiated cancer, the risk of levelⅡ increased accompanying the worsening of differentiation. Conclusions The cognition to principle of LNM, especially the EGC in lower stomach, contribute to individualized surgery therapy and offer theoretical support for microinvasive operation.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-07-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.07.007
Li Huabin, Liu Junlai, L. Yuyou, W. Dong, Gui Xiaoyan, H. Jun
Objective To detect all methods of localization in the insulinomas,and promote the rate of localization in insulinomas.Methods Between April 1990 and April 1999,28 patients of insulinomas that confirmed by operation and pathology.US,CT,MRI and DSA were used for preoperative diagnosis,IOUS,PVS and touching were used for intraoperative diagnosis,and analyzed the results of operation.Results The rates of localization were 28.6% with US,32.2% with CT,41.7% with MRI,50.0% with DSA,82.1% with touching,and 92.3% with IOUS and PVS.The rates of preoperative were higher than that intraoperative.Conclusion The rates of localization were so lower in preoperative diagnosis that did not be detected repeatedly,but intraoperative diagnosis was very vital.IOUS not only to promote the localizative sensitivity,but also to discrease the rates of operative complication.
{"title":"THE ASSESSMENT OF LOCALITIVE METHODS IN INSULINOMAS","authors":"Li Huabin, Liu Junlai, L. Yuyou, W. Dong, Gui Xiaoyan, H. Jun","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.07.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.07.007","url":null,"abstract":"Objective To detect all methods of localization in the insulinomas,and promote the rate of localization in insulinomas.Methods Between April 1990 and April 1999,28 patients of insulinomas that confirmed by operation and pathology.US,CT,MRI and DSA were used for preoperative diagnosis,IOUS,PVS and touching were used for intraoperative diagnosis,and analyzed the results of operation.Results The rates of localization were 28.6% with US,32.2% with CT,41.7% with MRI,50.0% with DSA,82.1% with touching,and 92.3% with IOUS and PVS.The rates of preoperative were higher than that intraoperative.Conclusion The rates of localization were so lower in preoperative diagnosis that did not be detected repeatedly,but intraoperative diagnosis was very vital.IOUS not only to promote the localizative sensitivity,but also to discrease the rates of operative complication.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-07-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.07.009
Zhang Wenjuan, Fu Xiaoying, L. Ping, Wen Shilin
Objective To improve diagnosis effectiveness for patients with multiple endocrine neoplasia(MEN).Methods 68 patients with MEN were reviewed in this paper.The diagnosis,clnical features and principle of treatment were discussed.Results (1)MEN-Ⅰ 22.05%,MEN-Ⅱ 36.86%,MEN-Ⅲ 8.82% MEN-Ⅰ,Ⅱ 33.72%.(2)The cases in female were more than male and ten years earlier than male.(3)Endocrinophathies involred in order were thyroid,adrenal medulla,parathroid and islet.Conclusion It is important that more than one endocrinopathy be examined in doubtful cases.
{"title":"MULTIPLE ENDOCRME NEOPLASIA-AN ANALYSIS OF 68 CASES","authors":"Zhang Wenjuan, Fu Xiaoying, L. Ping, Wen Shilin","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.07.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.07.009","url":null,"abstract":"Objective To improve diagnosis effectiveness for patients with multiple endocrine neoplasia(MEN).Methods 68 patients with MEN were reviewed in this paper.The diagnosis,clnical features and principle of treatment were discussed.Results (1)MEN-Ⅰ 22.05%,MEN-Ⅱ 36.86%,MEN-Ⅲ 8.82% MEN-Ⅰ,Ⅱ 33.72%.(2)The cases in female were more than male and ten years earlier than male.(3)Endocrinophathies involred in order were thyroid,adrenal medulla,parathroid and islet.Conclusion It is important that more than one endocrinopathy be examined in doubtful cases.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87889950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-06-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.06.009
Yuan Dongfeng, Wan Guangsheng
Objective The changes of peripheral T cell subgroup in patients with rectal cancer preoperatively and postoperatively were studied dynamicly.Method Peripheral T cell subgroup of 46 patients with rectal cancer was measured dynamicly by the monoclonar antibody enzyme labelling techniques during the preoperative and postoperative period.Result (1)CD 3 cell and CD 4 cell decreased markedly,the CD 4/CD 8 rate increased apparently in patients with rectal cancer.(2)Depressed immunity was related to the term of cancer.(3)The immunity of patients treated by radical rectal resection may recover gradually,the immunity of patients treated by palliative rectal resection,colostomy and laparotomy was depressed constantly.Conclusion The depressed immunity of patient with rectal cancer was related to the tumour preponderance.T cell subgroup dynamic surveillance was important to juide the possibility of recurrence and prognosis in patient with rectal cancer.
{"title":"DYNAMIC OBSERVATION OF PERIPHERAL T CELL SUBGROUP IN PATIENTS WITH RECTAL CANCER PREOPERATIVELY AND POSTOPERATIVELY","authors":"Yuan Dongfeng, Wan Guangsheng","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.06.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.06.009","url":null,"abstract":"Objective The changes of peripheral T cell subgroup in patients with rectal cancer preoperatively and postoperatively were studied dynamicly.Method Peripheral T cell subgroup of 46 patients with rectal cancer was measured dynamicly by the monoclonar antibody enzyme labelling techniques during the preoperative and postoperative period.Result (1)CD 3 cell and CD 4 cell decreased markedly,the CD 4/CD 8 rate increased apparently in patients with rectal cancer.(2)Depressed immunity was related to the term of cancer.(3)The immunity of patients treated by radical rectal resection may recover gradually,the immunity of patients treated by palliative rectal resection,colostomy and laparotomy was depressed constantly.Conclusion The depressed immunity of patient with rectal cancer was related to the tumour preponderance.T cell subgroup dynamic surveillance was important to juide the possibility of recurrence and prognosis in patient with rectal cancer.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74682058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-05-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.008
Zhang Shu-ya, Chen Hong-tao
Objective To investigate the relationship between of serum bilirubin concentrations and risk of coronary heart drsease (CHD). Methods Serum bilirubin concentrations were determined in 12 cases with acute myocardial infarction(AMI)、37 cases with unstable angina pectoris (UAP) and 30 cases with UAP with arrhythmia. Results The serum total bilirubin(TB)、direct bilirubin(DB)、indirect bilirubin(IB) concentrations were lower in the three study groups of CHD than in the controls. There was significant difference between the patients with CHD and the controls. However, there was no significant difference among the three study groups of CHD. Conclusion Serum bilirubin concentrations was inversely and statistically significantly related to risk of CHD.
{"title":"INVESTIGATION ON ASSOCIATION OF SERUM BILIRUBIN CONCENTRATION WITH RISK OF CORONARY HEART DISEASE","authors":"Zhang Shu-ya, Chen Hong-tao","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.05.008","url":null,"abstract":"Objective To investigate the relationship between of serum bilirubin concentrations and risk of coronary heart drsease (CHD). Methods Serum bilirubin concentrations were determined in 12 cases with acute myocardial infarction(AMI)、37 cases with unstable angina pectoris (UAP) and 30 cases with UAP with arrhythmia. Results The serum total bilirubin(TB)、direct bilirubin(DB)、indirect bilirubin(IB) concentrations were lower in the three study groups of CHD than in the controls. There was significant difference between the patients with CHD and the controls. However, there was no significant difference among the three study groups of CHD. Conclusion Serum bilirubin concentrations was inversely and statistically significantly related to risk of CHD.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-05-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.011
Mao Yao-sheng, You Rong-kai
Objective To observe noninvasive bi-level positive pressure ventilation for the treatment of severe acute left heart failure.Methods 16 patients with hypoxemia due to severe acute heart failure with non-reaction to the normal treatment received noninvasive bi-level positive pressure ventilation and were monitored under clinical symptoms,signs,traumatic arterial blood pressure and blood gas analysis.Results 16 patients survived and 1 died with success rate of 93.7%.After two-hour therapy,the patients vital signs were stable and PaO 2 and SaO 2 went up.Conclusion Noninvasive bi-level positive pressure ventilation can decrease the pulmonary interstitial and alveolar edema,improve left heart function through adjusting pressure support and end-respiratory positive pressure.It also improve the rate of V/Q,facilitate gas exchange,and promote PaO 2 and SaO 2.
{"title":"OBSERVATION OF NONINVASIVE BI-LEVEL POSITIVE PRESSURE VENTILATION FOR THE TREATMENT OF SEVERE ACUTE LEFT HEART FAILURE","authors":"Mao Yao-sheng, You Rong-kai","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.05.011","url":null,"abstract":"Objective To observe noninvasive bi-level positive pressure ventilation for the treatment of severe acute left heart failure.Methods 16 patients with hypoxemia due to severe acute heart failure with non-reaction to the normal treatment received noninvasive bi-level positive pressure ventilation and were monitored under clinical symptoms,signs,traumatic arterial blood pressure and blood gas analysis.Results 16 patients survived and 1 died with success rate of 93.7%.After two-hour therapy,the patients vital signs were stable and PaO 2 and SaO 2 went up.Conclusion Noninvasive bi-level positive pressure ventilation can decrease the pulmonary interstitial and alveolar edema,improve left heart function through adjusting pressure support and end-respiratory positive pressure.It also improve the rate of V/Q,facilitate gas exchange,and promote PaO 2 and SaO 2.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75702564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-05-15DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.009
Du Zheng-long, Kuang Zhu-sheng, Xiong Rong-sheng, W. Zhi-gang, Liu Yi-bo, Xiao Hong-tao, B. Tao, Deng Sheng, Z. Fu
Objective To determine the effect of 6-aminocaproic acid (EACA) to reduce postoperation bleeding following in mitral valve replacement.Method 50 adult patients uddergoing mitral valve replacement was adopted a double-bisind randomized trial to be divided into two groups.Each group is 25 patients.The patients in control groups received NS,the ones in study groups received NS as same as control groups but added EACE 10 g by intravation.The bleeding amount in cavitas thoracis were recorded on the sixth,twenty-fourth postoperative hours and ACT was recorded as well.Results The bleeding amount in study groups on the sixth postoperative hours were (290.0±41.3) ml.On twenty-fourth postoperative hours were (336.3±81.3) ml.The bleeding amount in control groups on the sixth postoperative hours were (393.4±73.6) ml.On twenty-fourth postoperative hours were (450.0±79.6) ml.The bleeding amount in study groups were decreased significantly as compared with in control groups (P0.05).Conclusion:6-aminocaproic acid can reduce postoperation bleeding following in mitral valve replacement.
{"title":"THE USE OF 6-AMINOCAPROIC ACID (EACA) TO REDUCE POSTOPERATIVE BLEEDING FOLLOWING IN MITRAL VALVE REPLACEMENT","authors":"Du Zheng-long, Kuang Zhu-sheng, Xiong Rong-sheng, W. Zhi-gang, Liu Yi-bo, Xiao Hong-tao, B. Tao, Deng Sheng, Z. Fu","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.05.009","url":null,"abstract":"Objective To determine the effect of 6-aminocaproic acid (EACA) to reduce postoperation bleeding following in mitral valve replacement.Method 50 adult patients uddergoing mitral valve replacement was adopted a double-bisind randomized trial to be divided into two groups.Each group is 25 patients.The patients in control groups received NS,the ones in study groups received NS as same as control groups but added EACE 10 g by intravation.The bleeding amount in cavitas thoracis were recorded on the sixth,twenty-fourth postoperative hours and ACT was recorded as well.Results The bleeding amount in study groups on the sixth postoperative hours were (290.0±41.3) ml.On twenty-fourth postoperative hours were (336.3±81.3) ml.The bleeding amount in control groups on the sixth postoperative hours were (393.4±73.6) ml.On twenty-fourth postoperative hours were (450.0±79.6) ml.The bleeding amount in study groups were decreased significantly as compared with in control groups (P0.05).Conclusion:6-aminocaproic acid can reduce postoperation bleeding following in mitral valve replacement.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82921982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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