Artificial intelligence (AI) is transforming healthcare, with large language models emerging as important tools for clinical practice, education, and research. To use it safely and effectively, healthcare professionals need to understand how it works, and how it fails. Using practical clinical examples, the authors explain the subset of AI called large language models, highlighting their capabilities and their limitations.
{"title":"Artificial intelligence in medicine: How it works, how it fails.","authors":"Rick Rejeleene, Neil B Mehta","doi":"10.3949/ccjm.93a.25089","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25089","url":null,"abstract":"<p><p>Artificial intelligence (AI) is transforming healthcare, with large language models emerging as important tools for clinical practice, education, and research. To use it safely and effectively, healthcare professionals need to understand how it works, and how it fails. Using practical clinical examples, the authors explain the subset of AI called large language models, highlighting their capabilities and their limitations.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"113-120"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernardo Henrique Mendes Correa, Ali Mushtaq, Ali Awada, Faiz Anwer, Anam Ashfaque
{"title":"Rapidly progressive kidney failure in an 82-year-old man with respiratory symptoms.","authors":"Bernardo Henrique Mendes Correa, Ali Mushtaq, Ali Awada, Faiz Anwer, Anam Ashfaque","doi":"10.3949/ccjm.93a.25037","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25037","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"99-105"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Elmasry, Allon Kahn, Lisa Marks, Neera Agrwal
{"title":"Should potassium-competitive acid blockers replace proton pump inhibitors as first-line therapy for patients with severe (Los Angeles grade C or D) esophagitis?","authors":"Sandra Elmasry, Allon Kahn, Lisa Marks, Neera Agrwal","doi":"10.3949/ccjm.93a.25044","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25044","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"84-87"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preventing cirrhosis: Why primary care clinicians should screen for liver disease in patients who drink heavily.","authors":"Pranay Nadella, Esperance Schaefer, Clare Landefeld","doi":"10.3949/ccjm.93a.25045","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25045","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"88-93"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Right ventricular failure in a young man.","authors":"Keerthana Sankar, Yuri Matusov","doi":"10.3949/ccjm.93a.25048","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25048","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"106-112"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Our Peer Reviewers for 2025.","authors":"Brian F Mandell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"71"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony E Divito, Matthew Sharobeem, Gausan R Bajracharya, Basem B Abdelmalak
{"title":"Suzetrigine: A novel nonopioid systemic analgesic.","authors":"Anthony E Divito, Matthew Sharobeem, Gausan R Bajracharya, Basem B Abdelmalak","doi":"10.3949/ccjm.93a.25087","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25087","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"94-98"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Profound xanthomas in a young man.","authors":"Lex Leonhardt, Natallia Maroz","doi":"10.3949/ccjm.93a.24093","DOIUrl":"https://doi.org/10.3949/ccjm.93a.24093","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"73-75"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Xanthomas: A clue to undiagnosed lipid disorders.","authors":"Ashish Sarraju","doi":"10.3949/ccjm.93a.25116","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25116","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"76-77"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new direction in pain management?","authors":"Brian F Mandell","doi":"10.3949/ccjm.93b.02026","DOIUrl":"https://doi.org/10.3949/ccjm.93b.02026","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 2","pages":"67-68"},"PeriodicalIF":4.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}