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Impact of chrono-radiotherapy on the prognosis and treatment-related toxicity in patients with locally advanced nasopharyngeal carcinoma: A multicenter propensity-matched study 慢性放疗对局部晚期鼻咽癌患者预后和治疗相关毒性的影响:一项多中心倾向匹配研究
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-12 DOI: 10.1080/07420528.2024.2337887
Jie Lin, Xiantao Lin, Rong Zheng, Kehai Lin, Muhammad Khan, Xiuting Huang, Yunhong Tian, Baiyao Wang, BenHua Xu, Yawei Yuan, Zhong Huang
The timing of radiotherapy (RT) delivery has been reported to affect both cancer survival and treatment toxicity. However, the association among the timing of RT delivery, survival, and toxicity in...
据报道,放疗(RT)的给药时间会影响癌症患者的生存率和治疗毒性。然而,放疗时机、生存率和毒性之间的关系却并不明确。
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引用次数: 0
Chronobiology and chronomedicine: From molecular and cellular mechanisms to whole body interdigitating networks 时间生物学和时间医学:从分子和细胞机制到全身互联网络
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-11 DOI: 10.1080/07420528.2024.2339681
Roberto Refinetti
Published in Chronobiology International: The Journal of Biological and Medical Rhythm Research (Ahead of Print, 2024)
发表于《国际时间生物学》:生物和医学节律研究杂志》(2024 年提前出版)
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引用次数: 0
The impact of sleep education, light intervention and relaxation on sleep and mood in the elderly 睡眠教育、灯光干预和放松对老年人睡眠和情绪的影响
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-11 DOI: 10.1080/07420528.2024.2337007
Lucie Urbanová, Ondřej Vaníček, Kateřina Červená, Aleš Bartoš, Katarína Evansová
Sleep and light education (SLE) combined with relaxation is a potential method of addressing sleep and affective problems in older people. 47 participants took part in a four-week sleep education p...
睡眠和灯光教育(SLE)与放松相结合是解决老年人睡眠和情感问题的一种潜在方法。47名参与者参加了为期四周的睡眠教育课程。
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引用次数: 0
The influence of shift work: A bibliometric analysis of research progress and frontiers on health effects 轮班工作的影响:关于健康影响的研究进展和前沿的文献计量分析
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-08 DOI: 10.1080/07420528.2024.2337885
Shibo Chen, Qingquan Liu, Jianjun Yan
Shift work has been found to disrupt the circadian system, leading to negative health effects. The objective of this study was to assess the progress and frontiers in research on the health-related...
轮班工作会扰乱昼夜节律系统,从而对健康产生负面影响。这项研究的目的是评估与健康有关的轮班工作的研究进展和前沿。
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引用次数: 0
Prospective study of the association between chronotypes and depressive symptoms in Chinese university students: Moderating effects of PER1 gene DNA methylation 中国大学生时间型与抑郁症状关系的前瞻性研究PER1基因DNA甲基化的调节作用
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-03 DOI: 10.1080/07420528.2024.2337891
Tingting Li, Yuxuan Cao, Panfeng Zhou, Yang Xie, Shuman Tao, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu
Most studies have shown a link between chronotypes and mental health and have identified evening chronotypes (E-types) as a potential risk for depressive symptoms. However, the mechanisms behind th...
大多数研究都表明,时型与心理健康之间存在联系,并将晚间时型(E 型)确定为抑郁症状的潜在风险。然而,这些研究背后的机制是什么呢?
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引用次数: 0
The relationship between chronotype and food addiction: Serial mediation of social jetlag and psychological pain. 时间型与食物成瘾之间的关系:社会时差和心理痛苦的连续调解。
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-14 DOI: 10.1080/07420528.2024.2315220
Burcu Ceylan, Deniz Kocoglu-Tanyer, Zeynep Sacikara, Kubra Sultan Dengiz

This study evaluates how food addiction is related to chronotype, social jetlag, and psychological pain. Of the participants (n = 1,035 university students), 16.6% had a morning chronotype, 25.1% had an evening chronotype, and 25.1% were clinically addicted to eating. The mean sleep durations for participants were 7.41 ± 2.18 h and 8.95 ± 3.0 h on weekdays and weekends, respectively. The mean misalignment time for social jetlag was 1.45 ± 1.5 h. Food addiction, psychological pain, and social jetlag levels were high among participants with the evening chronotype. The risk factors for food addiction included being female, having an evening chronotype, and having high body mass index levels and psychological pain. The total indirect effect of psychological pain and social jetlag on the relationship between chronotype and food addiction was 20.6%. However, the social jetlag effect is relatively minor compared to psychological pain. The significant conclusions of this study are as follows. Clinical food addiction is prevalent among students, and a strong direct correlation between chronotype and food addiction was observed. The study emphasizes the importance of being aware of chronotype and mental status in establishing a healthy diet and lifestyle.

本研究评估了食物成瘾与时序型、社会时差和心理痛苦之间的关系。在参与者(n=1,035 名大学生)中,16.6% 的人有早晨时型,25.1% 的人有傍晚时型,25.1% 的人有临床饮食成瘾。参与者在工作日和周末的平均睡眠时间分别为 7.41 ± 2.18 小时和 8.95 ± 3.0 小时。晚睡型参与者的食物成瘾、心理痛苦和社交时差水平较高。食物成瘾的风险因素包括女性、傍晚时型、高体重指数水平和心理痛苦。心理痛苦和社会时差对时间型与食物成瘾之间关系的间接影响总计为 20.6%。然而,与心理痛苦相比,社会时差的影响相对较小。本研究的重要结论如下。临床食物成瘾在学生中普遍存在,并且观察到时间型与食物成瘾之间有很强的直接相关性。本研究强调了在建立健康饮食和生活方式时注意时间型和心理状态的重要性。
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引用次数: 0
The relationship between chronotype, psychological pain, problematic social media use, and suicidality among university students in Turkey. 土耳其大学生的时间型、心理痛苦、社交媒体使用问题和自杀倾向之间的关系。
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-19 DOI: 10.1080/07420528.2024.2320226
Ahmet Üzer, Ceren Uran, Elif Yılmaz, Şeima Nur Şahin, Muhammet Kaan Ersin, Rohat Hasret Yılmaz, Ayça Çıkla

Chronotype has been extensively linked to various psychological outcomes, including suicide, which significantly impacts the mortality rate among young adults worldwide. Research on the extent of these links is still ongoing. This cross-sectional study aimed to explore the complex relationships between chronotype, internet addiction, problematic social media use (PSMU), psychological pain, and suicidality in a student population. A total of 571 Turkish students (65.3% female, mean age 20.3 ± 1.63 years) completed the following scales: the Suicide Probability Scale (SPS), the Mee-Bunney Psychological Pain Assessment Scale (MBPPAS), the Social Media Disorder Scale (SMDS), the Internet Addiction Test (IAT), the Morningness - Eveningness Questionnaire (MEQ), and the Hospital Anxiety and Depression Scale (HADS). The results showed that the relationship between chronotype and suicidality was partially mediated by SMDS and MBPPAS but not by anxiety, depression, or IAT. These findings suggest that psychological pain and PSMU may be important factors that contribute to suicidality in evening-type individuals. These findings have significant implications for the development of interventions aimed at reducing suicidality among evening-type individuals. By addressing the underlying factors of psychological pain and PSMU, it may be possible to mitigate the increased risk of suicidality among this population.

时间型与包括自杀在内的各种心理结果有着广泛的联系,自杀严重影响着全球青壮年的死亡率。有关这些关联程度的研究仍在进行中。这项横断面研究旨在探讨学生群体中的时间型、网络成瘾、问题社交媒体使用(PSMU)、心理痛苦和自杀倾向之间的复杂关系。共有 571 名土耳其学生(65.3% 为女性,平均年龄(20.3 ± 1.63)岁)完成了以下量表:自杀可能性量表(SPS)、米-班尼心理痛苦评估量表(MBPPAS)、社交媒体障碍量表(SMDS)、网络成瘾测试(IAT)、晨昏问卷(MEQ)和医院焦虑抑郁量表(HADS)。结果显示,时间型与自杀倾向之间的关系部分受 SMDS 和 MBPPAS 的调节,而不受焦虑、抑郁或 IAT 的调节。这些研究结果表明,心理痛苦和 PSMU 可能是导致黄昏型个体自杀倾向的重要因素。这些发现对于制定旨在减少黄昏型患者自杀倾向的干预措施具有重要意义。通过解决心理痛苦和 PSMU 的潜在因素,或许可以降低这类人群自杀风险的增加。
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引用次数: 0
Associations between chronotype and physical activity and well-being in adults. 成年人的时间型与体育锻炼和幸福感之间的关系。
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-27 DOI: 10.1080/07420528.2024.2321942
Sara Polańska, Aleksandra Karykowska, Łukasz Pawelec

Circadian rhythms influence a preference for people's time of activity and sleep time during the day and the hours of best performance. The aim of the study was to assess the associations between chronotype, physical activity, and well-being in adults aged 20-50. The chronotype, physical activity and well-being scores were determined based on the Composite Scale of Morningness (CSM) questionnaire, the International Physical Activity Questionnaire (IPAQ) and the Well-Being Index (WHO-5) questionnaire, respectively. Study data consisted of the answers of 213 respondents (including 64 men) who took part in an online survey. The Spearman rank correlation coefficient and the matrix scatter plots were used to check the correlations between the CSM score and quality of life parameters' values. General linear models (GLMs) were performed to find differences in quality-of-life parameters between different combinations of sex and chronotype. Morning types showed the highest value of well-being score (mean = 13.48) while evening types the lowest one (mean = 8.35). Evening types spent the most time sitting compared to other chronotypes. Results of this study revealed the significant effect of chronotype on well-being and physical activity among adults. These findings suggest that chronotype is an important factor that psychologists and personal trainers should take into account.

昼夜节律影响着人们对白天活动时间和睡眠时间以及最佳表现时间的偏好。这项研究旨在评估 20-50 岁成年人的时间型、体育活动和幸福感之间的关联。时间型、体力活动和幸福感得分分别根据晨昏综合量表(CSM)问卷、国际体力活动问卷(IPAQ)和幸福指数(WHO-5)问卷确定。研究数据由参加在线调查的 213 名受访者(包括 64 名男性)的答案组成。斯皮尔曼等级相关系数和矩阵散点图用于检验 CSM 分数与生活质量参数值之间的相关性。通过一般线性模型(GLM)来发现不同性别和时型组合之间生活质量参数的差异。晨型人的幸福感得分最高(平均 = 13.48),而晚型人的幸福感得分最低(平均 = 8.35)。与其他时间型的人相比,晚间型的人坐着的时间最多。这项研究的结果表明,时间型对成年人的幸福感和体育锻炼有显著影响。这些研究结果表明,时间型是心理学家和私人教练应该考虑的一个重要因素。
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引用次数: 0
Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice. 褪黑素介导的 C57BL/6J 实验性慢性中毒小鼠肠道微生物群的纠正性变化。
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-01 DOI: 10.1080/07420528.2024.2329205
Aliasgar Vohra, Rhydham Karnik, Mansi Desai, Hitarthi Vyas, Shruti Kulshrestha, Kapil Kumar Upadhyay, Prakash Koringa, Ranjitsinh Devkar

Chronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet (H) alone or in combination with photoperiodic shifts induced chronodisruption (CD) on gut microbiota of C57BL/6J male mice. Further, the merits of daily evening intraperitoneal administration of melatonin in restoring gut microbiota are studied herein. Experimental groups viz. H, CD and HCD mice recorded higher levels of serum pro-inflammatory cytokines (TNF-α and IL-6) and lower levels of the anti-inflammatory cytokine, IL-10. These findings correlate with a concomitant increase in the transcripts of TLR4, TNF-α, and IL-6 in small intestine of the said groups. A decrement in mRNA levels of Ocln, ZO-1 and Vdr in these groups implied towards an altered gut permeability. These results were in agreement with the observed decrement in percentage abundance of total gut microflora and Firmicutes: Bacteroidetes (F/B) ratio. Melatonin administration accounted for lower-level inflammation (serum and gut) along with an improvement in gut permeability markers. The total abundance of gut microflora and F/B ratio showed an improvement in all the melatonin-treated groups and the same is the highlight of this study. Taken together, our study is the first to report perturbations in gut microbiota resulting due to a combination of photoperiodic shifts induced CD and a high fat high calorie diet-induced lifestyle disorder. Further, melatonin-mediated rejuvenation of gut microbiome provides prima facie evidence of its role in improving gut dysbiosis that needs a detailed scrutiny.

长期摄入高热量饮食加上睡眠-觉醒周期的改变会导致昼夜节律紊乱,从而影响肠道微生物群,导致代谢综合征和相关疾病。在此,我们研究了高脂肪高果糖饮食(H)单独或结合光周期变化诱导的昼夜节律紊乱(CD)对 C57BL/6J 雄性小鼠肠道微生物群的影响。此外,本文还研究了每天傍晚腹腔注射褪黑激素对恢复肠道微生物群的益处。实验组,即 H 组、CD 组和 HCD 组小鼠的血清促炎细胞因子(TNF-α 和 IL-6)水平较高,而抗炎细胞因子 IL-10 水平较低。这些发现与上述各组小肠中 TLR4、TNF-α 和 IL-6 的转录本同时增加有关。在这些组中,Ocln、ZO-1 和 Vdr 的 mRNA 水平下降,这意味着肠道通透性发生了改变。这些结果与观察到的肠道微生物菌群总数和固着菌丰度百分比的下降相一致:类杆菌(F/B)比率。服用褪黑素可降低炎症水平(血清和肠道),同时改善肠道渗透性指标。所有褪黑素治疗组的肠道微生物菌群总丰度和F/B比值都有所改善,这也是本研究的亮点。综上所述,我们的研究首次报告了光周期变化诱导的 CD 和高脂肪高热量饮食诱导的生活方式紊乱共同导致的肠道微生物群紊乱。此外,褪黑素介导的肠道微生物群恢复活力为其在改善肠道菌群失调中的作用提供了初步证据,这需要进行详细的研究。
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引用次数: 0
Effects of shift work on sleep quality and cardiovascular function in Taiwanese police officers. 轮班工作对台湾警察睡眠质量和心血管功能的影响。
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.1080/07420528.2024.2324023
Yen-Ju Tseng, Anthony S Leicht, Jeffrey Cayaban Pagaduan, Ling-Chu Chien, Ying-Lin Wang, Chi-Sian Kao, Wei-Szu Lu, Yung-Sheng Chen

This study aimed to investigate the effects of shift work on sleep quality, cardiovascular function, and physical activity (PA) levels in Taiwanese police officers. Twenty-one male police officers aged 26.9 ± 4.1 years old located in Taipei voluntarily participated in this study. The participants completed the resting heart rate (HR) and hemodynamic variables (e.g. blood pressure, BP) before and after day-time (DTW) and night-time (NTW) shift work phases (5 working days and 2 resting days for each phase). Additionally, an actigraphy was administered to measure PA and sleep patterns in the last 3 working days. The average total sleep time and sleep efficiency were 278.5 ± 79. 6 min and 72.9 ± 10%, respectively, in the NTW phases, which were significantly lower than that in the DTW phases. A comparison of the PA characteristics between the two phases revealed that a lower proportion of moderate-vigorous PA (1.2 ± 0.8%) and a greater proportion of sedentary behaviour PA (74.8 ± 6.4%) was found in the NTW phases. The results of hemodynamic measures demonstrated that the police officers have significantly elevated systolic BP by 3.3% and diastolic BP by 3.9% after the NTW phases. Furthermore, the NTW phases exhibited a significantly higher percentage change ratio of systolic BP and diastolic BP compared to the DTW phases. Compared with the DTW phases, the NTW phase was significantly more likely to report higher decreasing parasympathetic-related HR variability with a range of -5.9% to -7.8%. In conclusion, night-time shift work resulted in negative physiological changes leading to adverse effects on the health and well-being of Taiwanese police officers.

本研究旨在调查轮班工作对台湾警察的睡眠质量、心血管功能和体力活动(PA)水平的影响。21 名年龄为(26.9±4.1)岁的台北市男性警官自愿参与了本研究。参加者在日间(DTW)和夜间(NTW)轮班工作阶段(每个阶段为 5 个工作日和 2 个休息日)前后完成了静息心率(HR)和血液动力学变量(如血压,BP)的测量。此外,还使用动觉仪测量了最后 3 个工作日的 PA 和睡眠模式。平均总睡眠时间和睡眠效率分别为 278.5 ± 79.6分钟和72.9±10%,明显低于DTW阶段。对两个阶段的 PA 特征进行比较后发现,NTW 阶段的中等强度 PA 比例较低(1.2±0.8%),而久坐行为 PA 比例较高(74.8±6.4%)。血液动力学测量结果表明,在 NTW 阶段后,警察的收缩压显著升高了 3.3%,舒张压显著升高了 3.9%。此外,与 DTW 阶段相比,NTW 阶段的收缩压和舒张压百分比变化率明显更高。与 DTW 阶段相比,NTW 阶段更有可能报告副交感神经相关心率变异性的较高降幅,降幅范围为 -5.9% 至 -7.8%。总之,夜班工作会导致负面的生理变化,从而对台湾警官的健康和福祉产生不利影响。
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Chronobiology International
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