Intracranial aneurysms with secondary bleb formation are considered to have an elevated risk of rupture due to localized geometric and hemodynamic instabilities. In this study, we perform a comparative computational fluid dynamics (CFD) analysis on five patient-specific aneurysm geometries, examining pre- and post-bleb configurations to evaluate hemodynamic changes associated with bleb development. Key metrics including wall shear stress (WSS), sac wall pressure, and intra-aneurysmal velocity were analyzed at peak systolic time points while oscillatory shear index (OSI) is obtained vial whole cardiac cycle. Results indicate that bleb formation introduces localized flow disturbances and hemodynamic variability, with case-dependent effects. Quantitatively, bleb regions exhibited up to a 36% reduction in mean WSS (e.g., Case E: 13.3 Pa → 9.8 Pa) and up to a 4-fold increase in minimum WSS (e.g., Case C: 0.21 Pa → 0.72 Pa in the bleb), reflecting strong spatial heterogeneity in shear loading. Despite these hemodynamic changes, the vessel wall in bleb regions becomes thinner and structurally weaker, reducing its resistance to blood pressure and thereby increasing rupture susceptibility. These findings emphasize the importance of multi-parametric hemodynamic evaluation—particularly WSS magnitude, OSI distribution, and flow patterns—in understanding bleb-induced changes in aneurysm stability. The study underscores the need for individualized risk assessment strategies that go beyond morphological classification alone.
扫码关注我们
求助内容:
应助结果提醒方式:
