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Medicolegal Sidebar: Taking Care of Professional Athletes-Is It Worth the Risk? 医疗法律侧记:照顾职业运动员--值得冒险吗?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-10 DOI: 10.1097/corr.0000000000003250
B Sonny Bal
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引用次数: 0
No Association Between Growth Hormone Therapy and Upper Extremity Physeal Tension Injuries: A Matched Case-control Study. 生长激素治疗与上肢骨骺拉力损伤之间无关联:一项匹配病例对照研究
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-10 DOI: 10.1097/corr.0000000000003248
Ruth H Jones,Samuel A Beber,Akshitha Adhiyaman,Olivia C Tracey,Emilie Lijesen,Daniel W Green,Peter D Fabricant
BACKGROUNDRecent evidence has identified a strong association between growth hormone therapy and physeal injuries in the lower extremity; however, few studies have investigated this association in the upper extremity.QUESTIONS/PURPOSES(1) Do pediatric patients with physeal tension injuries of the shoulder and elbow have higher odds of having exposure to recombinant growth hormone therapy than matched controls? (2) Are the odds of having exposure to recombinant growth hormone therapy in physeal tension injuries different when stratified by shoulder and elbow injuries?METHODSUsing a matched case-control study design, patients between 4 and 18 years of age treated at a large, urban, academic center from February 1, 2016, to November 6, 2023, were identified by ICD-10 codes using EPIC SlicerDicer, an electronic medical record-based data mining tool. Patients diagnosed with physeal tension injuries in the shoulder or elbow were included in the case group, and those with midshaft radius, metaphyseal radius, or both-bone forearm fractures were included in the control group. A total of 618 patients with physeal injuries and 1244 with non-physeal fractures were identified and screened for inclusion. After further chart review to confirm diagnoses, 46% (283) of patients with physeal injuries and 54% (670) of patients with non-physeal fractures were included. A further 6% (16) of patients with physeal injuries and 2% (15) of patients with non-physeal injuries were excluded due concomitant dislocations or missing data, resulting in 267 eligible patients with physeal injuries and 655 eligible patients with non-physeal fractures. Two patients with concurrent elbow and shoulder physeal injuries were additionally excluded from stratified analyses. Patients with physeal injuries and non-physeal fractures were 1:1 matched by age ± 0.5 years, sex, and BMI ± 2 kg/m2. In all, 522 patients were included in the analysis, including 261 patients with physeal injuries and 261 with non-physeal fractures. The mean ± SD ages for both patient groups was 13 ± 2 years (p = 0.44), 88% (229 of 261) of all participants were male, and the mean BMIs were 19.9 ± 3.0 kg/m2 and 19.4 ± 3.0 kg/m2 (p = 0.11), respectively. Growth hormone exposure was compared between patients with physeal injuries and non-physeal fractures using a conditional logistic regression model.RESULTSOverall, 4% (10 of 261) of patients with physeal injuries had exposure to growth hormone therapy as compared with 2% (4 of 261) of patients with non-physeal fractures (OR 2.5 [95% confidence interval 0.8 to 8.0]). Subgroup analyses of shoulder and elbow injuries demonstrated no difference in growth hormone exposure between patients with physeal injuries and non-physeal fractures (OR 2 [95% CI 0.4 to 10.2] and OR 3 [95% CI 0.6 to 14.9], respectively).CONCLUSIONIn light of these results, clinicians may not need to advise precaution against sports or other activities that put the upper extremity physes under stress when
背景最近的证据表明,生长激素治疗与下肢趾骨损伤之间存在密切联系;然而,很少有研究对上肢的这种联系进行调查。问题/提案(1)与匹配的对照组相比,肩部和肘部趾骨张力损伤的儿科患者接受重组生长激素治疗的几率更高吗?(2)按肩部和肘部损伤分层,趾骨张力损伤患者接受重组生长激素治疗的几率是否不同?方法采用匹配病例对照研究设计,使用基于电子病历的数据挖掘工具EPIC SlicerDicer,通过ICD-10代码识别2016年2月1日至2023年11月6日期间在一家大型城市学术中心接受治疗的4至18岁患者。确诊为肩部或肘部趾骨张力损伤的患者被纳入病例组,桡骨中轴、桡骨骺或双骨前臂骨折的患者被纳入对照组。经过筛选,共有 618 名骨干损伤患者和 1244 名非骨干骨折患者被纳入病例组。经进一步病历审查确诊后,46%(283 例)的趾骨损伤患者和 54%(670 例)的非趾骨骨折患者被纳入对照组。另有6%(16名)的趾骨损伤患者和2%(15名)的非趾骨损伤患者因同时脱位或数据缺失而被排除在外,因此符合条件的趾骨损伤患者有267名,符合条件的非趾骨骨折患者有655名。分层分析中还排除了两名同时患有肘部和肩部趾骨损伤的患者。趾骨损伤和非趾骨骨折患者的年龄(± 0.5 岁)、性别和体重指数(± 2 kg/m2)均为 1:1。共有 522 名患者被纳入分析,其中包括 261 名趾骨损伤患者和 261 名非趾骨骨折患者。两组患者的平均年龄(± SD)均为 13 ± 2 岁(P = 0.44),所有参与者中有 88% (261 人中的 229 人)为男性,平均体重指数分别为 19.9 ± 3.0 kg/m2 和 19.4 ± 3.0 kg/m2 (P = 0.11)。结果总体而言,4%的趾骨损伤患者(261例中的10例)接受过生长激素治疗,而2%的非趾骨骨折患者(261例中的4例)接受过生长激素治疗(OR值为2.5[95%置信区间为0.8-8.0])。对肩部和肘部损伤进行的分组分析表明,骨骺损伤患者与非骨骺骨折患者在生长激素暴露方面没有差异(OR 分别为 2 [95% CI 0.4 至 10.2] 和 OR 3 [95% CI 0.6 至 14.9])。不过,未来的多中心研究应进一步调查生长激素治疗与上肢趾骨损伤之间是否存在微妙的关联,而不是像之前在儿童和青少年患者下肢中发现的那样存在巨大关联。
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引用次数: 0
Letter to the Editor: A Conversation With … Emily Wilson PhD, Contemporary Interpreter of the Iliad, on Listening, Hearing, and Communicating. 致编辑的信:艾米莉-威尔逊(Emily Wilson)博士,《伊利亚特》的当代诠释者,关于倾听、聆听和交流。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-10 DOI: 10.1097/corr.0000000000003253
Lyn Jones
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引用次数: 0
Which Interventions Are Effective in Treating Sleep Disturbances After THA or TKA? A Systematic Review. 哪些干预措施能有效治疗 THA 或 TKA 后的睡眠障碍?系统综述。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-09 DOI: 10.1097/corr.0000000000003196
Emily Pilc,Sri Vibhaav Bankuru,Sarah F Brauer,John W Cyrus,Nirav K Patel
BACKGROUNDPoor sleep quality is a common complaint after total joint arthroplasty (TJA), and it is associated with reports of higher pain and worse functional outcomes. Several interventions have been investigated with the intent to reduce the incidence of postoperative sleep disturbance with varying effectiveness. An aggregate of the best available evidence, along with an evaluation of the quality of those studies, is needed to provide valuable perspective to physicians and to direct future research.QUESTIONS/PURPOSESIn this systematic review, we asked: (1) What is the reported efficacy of the most commonly studied medications and nonpharmacologic approaches, and (2) what are their side effects and reported complications?METHODSThis systematic review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search using a combination of controlled vocabulary and keywords was performed utilizing Medline (Ovid), Embase (Ovid), Cochrane Central, and Web of Science databases from database inception to 2023, with the last search occurring October 24, 2023, to identify studies that evaluated a sleep intervention on the effect of patient-reported sleep quality after THA or TKA. Inclusion criteria were clinical trials, comparative studies, and observational studies on adult patients who underwent primary TKA or THA for osteoarthritis and who completed validated sleep questionnaires to assess sleep quality postoperatively. We excluded studies on patients younger than 18 years, patients with sleep apnea, TKA or THA because of trauma or conditions other than osteoarthritis, revision TJA, studies in languages other than English, and studies from nonindexed journals or preprint servers. Two investigators independently screened 1535 studies for inclusion and exclusion criteria and extracted data from the included studies. Ultimately, 14 studies were included in this systematic review, including 12 randomized controlled trials and 2 prospective comparative studies. A total of 2469 participants were included, with a mean ± SD age of 65 ± 7 years and 38% men in control groups and 65 ± 7 years and 39% men in intervention groups. Sleep quality questionnaires utilized included the Pittsburgh Sleep Quality Index, Self-Rating Scale of Sleep, 100-mm VAS - Sleep, Sleep Disturbance Numeric Rating Scale, Likert scales, and one institutionally designed questionnaire. Quality analysis was performed utilizing the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Randomized Controlled Trials, where higher scores of 13 indicated a more reliable study, and the Newcastle-Ottawa Quality Assessment Scale for Cohort Studies, where higher scores of 9 indicated a more reliable study and scores < 5 represented a high risk of bias. Two of the randomized controlled trials scored a 12 of 13, and the remaining 10 met every criteria of the JBI checklist. Both comparative studies scored 5 of 9 possible points of th
背景睡眠质量差是全关节置换术(TJA)后的常见症状,与疼痛加剧和功能障碍相关。为了降低术后睡眠障碍的发生率,人们研究了多种干预措施,但效果不一。我们需要对现有的最佳证据进行汇总,并对这些研究的质量进行评估,以便为医生提供有价值的观点,并指导未来的研究。在本系统性综述中,我们提出了以下问题:(1)最常研究的药物和非药物方法的疗效如何;(2)它们的副作用和并发症如何?在 Medline (Ovid)、Embase (Ovid)、Cochrane Central 和 Web of Science 数据库中结合使用控制词汇和关键词进行了检索,检索时间从数据库建立之初到 2023 年,最后一次检索时间为 2023 年 10 月 24 日,以确定评估睡眠干预对 THA 或 TKA 术后患者报告的睡眠质量影响的研究。纳入标准为临床试验、比较研究和观察性研究,研究对象为因骨关节炎而接受初级 TKA 或 THA 的成年患者,他们在术后填写了有效的睡眠问卷以评估睡眠质量。我们排除了有关 18 岁以下患者、睡眠呼吸暂停患者、因创伤或骨关节炎以外的其他疾病而接受 TKA 或 THA、翻修 TJA 的研究、使用英语以外语言的研究以及来自非索引期刊或预印服务器的研究。两名研究人员根据纳入和排除标准独立筛选了 1535 项研究,并从纳入的研究中提取了数据。最终,14 项研究被纳入本系统综述,包括 12 项随机对照试验和 2 项前瞻性比较研究。共纳入了 2469 名参与者,对照组参与者的平均(±SD)年龄为 65 ± 7 岁,38% 为男性;干预组参与者的平均(±SD)年龄为 65 ± 7 岁,39% 为男性。采用的睡眠质量问卷包括匹兹堡睡眠质量指数、睡眠自评量表、100 毫米 VAS - 睡眠量表、睡眠障碍数字评定量表、李克特量表和一份机构设计的问卷。质量分析采用乔安娜-布里格斯研究所(JBI)的随机对照试验批判性评估核对表和纽卡斯尔-渥太华队列研究质量评估量表进行,前者得分越高(13 分)表示研究越可靠,后者得分越高(9 分)表示研究越可靠,得分小于 5 分表示偏倚风险高。在 13 项随机对照试验中,有两项获得了 12 分,其余 10 项符合 JBI 检查表的所有标准。结果发现,褪黑素和选择性环氧化酶-2抑制剂罗非昔布可在TJA术后第一周内为睡眠质量提供具有临床意义的益处。然而,由于担心增加心血管事件的风险,罗非昔布已于 2004 年从全球市场上撤下。另一种环氧化酶-2 抑制剂塞来昔布仍在市场上销售。其他干预措施均未显示出临床疗效。褪黑素的副作用包括头晕、头痛、麻痹和恶心,肝功能衰竭、自身免疫性疾病或正在服用华法林的患者禁用。罗非昔布的长期不良反应包括高血压、水肿和充血性心力衰竭,肾功能不全或正在服用华法林的患者禁用。褪黑素在老年患者中被认为是安全的,但使用罗非昔布时则应更加谨慎。褪黑素和罗非昔布可能对某些患者的睡眠质量有益,但医生在推荐这些干预措施之前需要了解其不良反应和禁忌症。此外,罗非昔布已不再在市场上销售。未来有必要进行调查,以评估副作用最小的干预措施的有效性,从而使医疗人员能够就TJA术后改善睡眠的干预措施做出明智的决定。
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引用次数: 0
"Dr. AI Will See You Now": How Do ChatGPT-4 Treatment Recommendations Align With Orthopaedic Clinical Practice Guidelines? "AI 博士现在就来见您":ChatGPT-4 治疗建议如何与骨科临床实践指南保持一致?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-06 DOI: 10.1097/CORR.0000000000003234
Tanios Dagher, Emma P Dwyer, Hayden P Baker, Senthooran Kalidoss, Jason A Strelzow
<p><strong>Background: </strong>Artificial intelligence (AI) is engineered to emulate tasks that have historically required human interaction and intellect, including learning, pattern recognition, decision-making, and problem-solving. Although AI models like ChatGPT-4 have demonstrated satisfactory performance on medical licensing exams, suggesting a potential for supporting medical diagnostics and decision-making, no study of which we are aware has evaluated the ability of these tools to make treatment recommendations when given clinical vignettes and representative medical imaging of common orthopaedic conditions. As AI continues to advance, a thorough understanding of its strengths and limitations is necessary to inform safe and helpful integration into medical practice.</p><p><strong>Questions/purposes: </strong>(1) What is the concordance between ChatGPT-4-generated treatment recommendations for common orthopaedic conditions with both the American Academy of Orthopaedic Surgeons (AAOS) clinical practice guidelines (CPGs) and an orthopaedic attending physician's treatment plan? (2) In what specific areas do the ChatGPT-4-generated treatment recommendations diverge from the AAOS CPGs?</p><p><strong>Methods: </strong>Ten common orthopaedic conditions with associated AAOS CPGs were identified: carpal tunnel syndrome, distal radius fracture, glenohumeral joint osteoarthritis, rotator cuff injury, clavicle fracture, hip fracture, hip osteoarthritis, knee osteoarthritis, ACL injury, and acute Achilles rupture. For each condition, the medical records of 10 deidentified patients managed at our facility were used to construct clinical vignettes that each had an isolated, single diagnosis with adequate clarity. The vignettes also encompassed a range of diagnostic severity to evaluate more thoroughly adherence to the treatment guidelines outlined by the AAOS. These clinical vignettes were presented alongside representative radiographic imaging. The model was prompted to provide a single treatment plan recommendation. Each treatment plan was compared with established AAOS CPGs and to the treatment plan documented by the attending orthopaedic surgeon treating the specific patient. Vignettes where ChatGPT-4 recommendations diverged from CPGs were reviewed to identify patterns of error and summarized.</p><p><strong>Results: </strong>ChatGPT-4 provided treatment recommendations in accordance with the AAOS CPGs in 90% (90 of 100) of clinical vignettes. Concordance between ChatGPT-generated plans and the plan recommended by the treating orthopaedic attending physician was 78% (78 of 100). One hundred percent (30 of 30) of ChatGPT-4 recommendations for fracture vignettes and hip and knee arthritis vignettes matched with CPG recommendations, whereas the model struggled most with recommendations for carpal tunnel syndrome (3 of 10 instances demonstrated discordance). ChatGPT-4 recommendations diverged from AAOS CPGs for three carpal tunnel syndrome vignettes; tw
背景:人工智能(AI)被设计用来模拟历史上需要人类互动和智力的任务,包括学习、模式识别、决策和解决问题。虽然像 ChatGPT-4 这样的人工智能模型在医学执照考试中表现令人满意,表明其具有支持医疗诊断和决策的潜力,但据我们所知,目前还没有研究评估过这些工具在给定常见骨科疾病的临床案例和代表性医学影像时提出治疗建议的能力。问题/目的:(1)ChatGPT-4 生成的常见骨科疾病治疗建议与美国骨科外科医生学会(AAOS)临床实践指南(CPG)和骨科主治医生的治疗计划之间的一致性如何?(2) ChatGPT-4 生成的治疗建议在哪些具体方面与 AAOS CPGs 存在差异?确定了与 AAOS CPGs 相关的 10 种常见骨科疾病:腕管综合征、桡骨远端骨折、盂肱关节骨关节炎、肩袖损伤、锁骨骨折、髋部骨折、髋关节骨关节炎、膝关节骨关节炎、前交叉韧带损伤和急性跟腱断裂。针对每种病症,我们利用本机构管理的 10 名身份已被确认的患者的医疗记录来构建临床小故事,每个小故事都有一个足够清晰的单独诊断。小故事还包括一系列诊断严重程度,以便更全面地评估是否符合 AAOS 概述的治疗指南。这些临床小故事与具有代表性的放射成像一起展示。模型被提示提供单一治疗方案建议。每个治疗方案都与既定的 AAOS CPGs 以及治疗特定患者的骨科主治医生记录的治疗方案进行了比较。对 ChatGPT-4 建议与 CPGs 有偏差的病例进行了审查,以确定错误模式并进行总结:结果:在 90% 的临床案例中(100 个案例中的 90 个),ChatGPT-4 提供的治疗建议与 AAOS CPGs 一致。ChatGPT 生成的计划与骨科主治医生推荐的计划之间的一致性为 78%(100 例中有 78 例)。ChatGPT-4 对骨折小案例以及髋关节和膝关节炎小案例的建议与 CPG 建议的吻合率为 100%(30 项中的 30 项),而该模型在腕管综合征的建议方面最为吃力(10 项中有 3 项不吻合)。ChatGPT-4 的建议与 AAOS CPG 存在分歧,包括三个腕管综合症小案例;两个前交叉韧带损伤、肩袖损伤和盂肱关节骨关节炎小案例;以及一个急性跟腱断裂小案例。在这些情况下,ChatGPT-4 通常难以正确解释损伤的严重程度和进展,无法将患者因素(如生活方式或合并症)纳入决策,也无法识别手术禁忌症:结论:ChatGPT-4 可以生成符合 CPGs 的准确治疗方案,但在需要将多种患者因素纳入决策以及了解疾病严重程度和进展情况时也会犯错。在使用人工智能工具支持决策时,医生必须严格评估临床全貌:ChatGPT-4 可作为按需诊断的辅助工具,但以患者为中心的决策仍应由医生做出。
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引用次数: 0
Editor's Spotlight/Take 5: What Is the Patient-reported Outcome and Complication Incidence After Operative Versus Nonoperative Treatment of Minimally Displaced Tibial Plateau Fractures? 编辑聚焦/第 5 期:胫骨平台微脱位骨折手术治疗与非手术治疗后的患者报告结果和并发症发生率如何?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-05 DOI: 10.1097/CORR.0000000000003237
Seth S Leopold
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引用次数: 0
No Short-term Clinical Benefit to Bovine Collagen Implant Augmentation in Primary Rotator Cuff Repair: A Matched Retrospective Study. 原发性肩袖修复术中的牛胶原蛋白植入物增量短期内无临床益处:一项匹配回顾性研究
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-05 DOI: 10.1097/CORR.0000000000003247
Mark Haft, Steve S Li, Zachary C Pearson, Uzoma Ahiarakwe, Amie F Bettencourt, Umasuthan Srikumaran
<p><strong>Background: </strong>Bovine bioinductive collagen implants (herein, "bovine collagen implant") can be used to augment rotator cuff repair. Concern exists that these bovine collagen implants may not yield clinical benefits and may actually increase postoperative stiffness and the need for reoperation.</p><p><strong>Questions/purposes: </strong>Among patients who underwent primary rotator cuff repair with or without a bovine collagen implant, we asked: (1) Did the proportion of patients undergoing reoperation for postoperative stiffness and inflammation differ between the bovine collagen implant and control groups? (2) Did short-term patient-reported outcomes differ between the two groups? (3) Did the proportion of patients receiving postoperative methylprednisolone prescriptions and corticosteroid injections differ between the two groups?</p><p><strong>Methods: </strong>We performed a retrospective, matched, comparative study of patients 18 years and older with minimum 2-year follow-up who underwent primary arthroscopic repair of partial or full-thickness rotator cuff tears diagnosed by MRI. All procedures were performed by one surgeonbetween February 2016 and December 2021. During the period in question, this surgeon broadly offered the bovine collagen implant to all patients who underwent rotator cuff repair and who (1) consented to xenograft use and (2) had surgery at a facility where the bovine collagen implant was available. The bovine collagen implant was used in rotator cuff tears of all sizes per the manufacturer's instructions. A total of 312 patients were considered for this study (243 control, 69 implant). Minimum 2-year clinical follow-up data were available for 83% (201 of 243) of patients in the control group and 90% (62 of 69) of patients in the bovine collagen implant group. After we applied the exclusion criteria, 163 control and 47 implant group patients remained and were eligible for matching. Propensity score matching was conducted to balance cohorts by age, gender, race (Black, White, other), ethnicity (Hispanic, non-Hispanic), health insurance status, Area Deprivation Index, BMI, American Society of Anesthesiologists physical status classification, diabetes, smoking, rotator cuff tear size, concomitant surgical procedures, preoperative American Shoulder and Elbow Surgeons (ASES) score, Subjective Shoulder Value (SSV), VAS score for pain, and shoulder ROM. We included 141 patients (47 in the implant group and 94 in the control group) after matching. Patients were categorized according to whether they received the bovine collagen implant. Before matching, the control cohort was older (mean ± SD 57 ± 10 years versus 52 ± 11 years; p = 0.004), more likely to be White (58% versus 23%; p < 0.001), with a smaller proportion of concomitant distal clavicle excisions (43% versus 21%; p = 0.003), and a smaller proportion of "other" concomitant procedures (17% versus 6%; p = 0.011) compared with the implant cohort. After match
由于缺乏临床疗效且术后并发症可能增加,我们建议不要使用这些牛胶原蛋白植入物,除非高质量的随机对照试验能够证明其临床疗效、成本效益和总体安全性:证据等级:三级,治疗研究。
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引用次数: 0
Not the Last Word: Restrictive Covenants Can be Liberating. 并非一言九鼎:限制性盟约可以解放思想。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-05 DOI: 10.1097/CORR.0000000000003241
Joseph Bernstein
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引用次数: 0
What Are the Complications, Reconstruction Survival, and Functional Outcomes of Modular Prosthesis and Allograft-prosthesis Composite for Proximal Femur Reconstruction in Children With Primary Bone Tumors? 在原发性骨肿瘤患儿的股骨近端重建中,模块化假体和同种异体假体复合材料的并发症、重建存活率和功能疗效如何?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-03 DOI: 10.1097/CORR.0000000000003245
Ahmed Atherley O'Meally, Giovanni Rizzi, Monica Cosentino, Hisaki Aiba, Ayano Aso, Konstantina Solou, Laura Campanacci, Federica Zuccheri, Barbara Bordini, Davide Maria Donati, Costantino Errani
<p><strong>Background: </strong>Proximal femur reconstruction after bone tumor resection in children is a demanding surgery for orthopaedic oncologists because of the small bone size and possible limb-length discrepancy at the end of skeletal growth owing to physis loss. The most commonly used reconstruction types used for the proximal femur are modular prostheses and allograft-prosthesis composites. To our knowledge, there are no previous studies comparing the outcomes after modular prosthesis and allograft-prosthesis composite reconstruction of the proximal femur in children with primary bone tumors.</p><p><strong>Questions/purposes: </strong>(1) What was the cumulative incidence of reoperation for any reason after allograft-prosthesis composite and modular prosthesis reconstructions of the proximal femur in children with primary bone tumors? (2) What was the cumulative incidence of reconstruction removal or revision arthroplasty in those two treatment groups? (3) What complications occurred in those two treatment groups that were managed without further surgery or with surgery without reconstruction removal?</p><p><strong>Methods: </strong>Between 2000 and 2021, 54 children with primary bone tumors underwent resection and reconstruction of the proximal femur at a single institution. During that time, allograft-prosthesis composite reconstruction was used in very young children, in whom we prioritize bone stock preservation for future surgeries, and children with good response to chemotherapy, while modular prosthesis reconstruction was used in older children and children with metastatic disease at presentation and poor response to chemotherapy. We excluded three children in whom limb salvage was not possible and 11 children who underwent either reconstruction with free vascularized fibular graft and massive bone allograft (n = 3), an expandable prosthesis (n = 3), a massive bone allograft reconstruction (n = 2), a rotationplasty (n = 1), standard (nonmodular) prosthesis (n = 1), or revision of preexisting reconstruction (n = 1). Further, we excluded two children who were not treated surgically, three children with no medical or imaging records, and three children with no follow-up. All the remaining 32 children with reconstruction of the proximal femur (12 children treated with modular prosthesis and 20 children treated with allograft-prosthesis composite reconstruction) were accounted for at a minimum follow-up time of 2 years. Children in the allograft-prosthesis group were younger at the time of diagnosis than those in the modular prosthesis group (median 8 years [range 1 to 16 years] versus 15 years [range 9 to 17 years]; p = 0.001]), and the follow-up in the allograft-prosthesis composite group was longer (median 5 years [range 1 to 23 years] versus 3 years [range 1 to 15 years]; p = 0.37). Reconstruction with hemiarthroplasty was performed in 19 of 20 children in the allograft-prosthesis composite group and in 9 of 12 children in the mod
背景:儿童骨肿瘤切除术后的股骨近端重建手术对骨科肿瘤学家来说是一项要求很高的手术,因为儿童骨骼较小,在骨骼生长末期可能会因骺线缺失而导致肢体长度不一致。股骨近端最常用的重建类型是模块化假体和同种异体假体复合体。问题/目的:(1)原发性骨肿瘤患儿股骨近端异体假体复合重建和模块化假体重建后因任何原因再次手术的累计发生率是多少?(2)在这两组治疗中,重建移除或翻修关节置换术的累计发生率是多少?(3)在这两组治疗中,未进行进一步手术或手术后未拆除重建的治疗组出现了哪些并发症?2000年至2021年间,54名患有原发性骨肿瘤的儿童在一家医疗机构接受了股骨近端切除和重建手术。在此期间,同种异体移植-假体复合重建用于年龄较小的患儿(我们优先考虑保留骨量以备将来手术之用)和化疗反应良好的患儿,而模块化假体重建用于年龄较大的患儿和发病时有转移性疾病且化疗反应不佳的患儿。我们排除了3名无法进行肢体挽救的患儿,以及11名接受了游离血管化纤维移植和大块骨异体移植重建(3人)、可扩张假体(3人)、大块骨异体移植重建(2人)、旋转成形术(1人)、标准(非模块化)假体(1人)或原有重建翻修(1人)的患儿。此外,我们还排除了两名未接受手术治疗的患儿、三名无医疗或影像记录的患儿以及三名未接受随访的患儿。其余32名股骨近端重建患儿(12名采用模块化假体,20名采用同种异体假体复合重建)的随访时间均不少于2年。与模块假体组相比,同种异体假体组的患儿在确诊时年龄更小(中位数为8岁[1至16岁]对15岁[9至17岁];P = 0.001]),而同种异体假体复合组的随访时间更长(中位数为5年[1至23年]对3年[1至15年];P = 0.37)。在同种异体假体复合组的20名患儿中,19名患儿接受了半关节成形术重建,在模块化假体组的12名患儿中,9名患儿接受了半关节成形术重建。在同种异体假体复合重建组的19名患儿中,16名患儿使用了双极头,3名患儿使用了无髋臼杯的股骨陶瓷头。模块化假体组的所有9名患儿均采用了双极半关节成形术。同种异体假体复合重建组和模块化假体重建组分别有一名和三名患儿接受了全关节成形术。我们计算了两组患儿因任何原因再次手术的累计发生率以及重建移除或翻修关节成形术的累计发生率;我们还报告了两组患儿非手术治疗的严重并发症的定性描述:根据现有数据,两组患者在10年内任何原因的再手术累计发生率没有差异(同种异体移植-假体复合组为36%[95%置信区间为15%至58%],模块化股骨近端置换组为28%[95% CI为5%至58%])。在现有数据中,重建移除或10年后翻修关节置换术的累积发生率在两组之间同样没有差异(分别为10% [95% CI 2% 至 28%] 与 12% [95% CI 0% 至 45%])。在同种异体移植-假体复合组(20名患儿)中,髋关节不稳定(3例)、不愈合(2例)、大转子骨折(1例)、螺钉松动(1例)、肢体长度不一致(1例)以及髋臼磨损引起的髋痛(1例)均通过手术治疗,无需移除假体。未经手术治疗的并发症包括:转子区异体移植物吸收(4 例)、大转子骨折(4 例)、肢体长度不一致(6 例)和髋臼磨损引起的髋痛(2 例)。在模块化假体组(12名儿童)中,髋关节不稳定(1名)、髋臼磨损引起的髋关节疼痛(1名)和肢体长度不一致(1名)均通过手术治疗,无需移除假体。
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引用次数: 0
CORR Insights®: Ultrasound-guided Hydrogel Injection Provides Better Therapeutic Effects After Hand Tendon Surgery Than Intraoperative Injection: A Randomized Controlled Trial. CORR Insights®:超声引导水凝胶注射比术中注射在手部肌腱手术后提供更好的治疗效果:随机对照试验。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-03 DOI: 10.1097/CORR.0000000000003216
Julia Blackburn
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引用次数: 0
期刊
Clinical Orthopaedics and Related Research®
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