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CORR Synthesis: How Should PROM Thresholds Be Determined and Interpreted to Reflect Clinically Meaningful Change in Orthopaedic Surgery? CORR综合:如何确定和解释胎膜早破阈值以反映骨科手术临床有意义的变化?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-16 DOI: 10.1097/corr.0000000000003815
Neel Vallurupalli,Benjamin Padon,Jie J Yao
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引用次数: 0
Letter to the Editor: Editorial: Fully Compromised, but Thanks All the Same to Our Peer Reviewers. 致编辑的信:社论:完全妥协,但同样感谢我们的同行审稿人。
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-15 DOI: 10.1097/CORR.0000000000003830
Joseph Bernstein
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引用次数: 0
Your Best Life: Care for Your Brain and Put Your Phone Away! 你最好的生活:照顾好你的大脑,把你的手机收起来!
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-09 DOI: 10.1097/CORR.0000000000003823
John D Kelly
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引用次数: 0
Higher Area Deprivation Index Is Associated With Greater Practice-initiated Perioperative Communication Workload in Patients With Primary Total Joint Arthroplasty. 在初次全关节置换术患者中,较高的区域剥夺指数与更大的实践发起的围手术期沟通工作量相关。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-08 DOI: 10.1097/corr.0000000000003818
Alan David Lam,Jessica H Leipman,Samantha S Meacock,Nihir Parikh,Matthew B Sherman,Yale A Fillingham,Chad A Krueger
BACKGROUNDAlthough deficits in social determinants of health (SDOH) have been previously associated with adverse clinical outcomes after primary THA and TKA, their role in the perioperative communication workload remains poorly characterized. Even though it remains essential to appropriately identify and address modifiable SDOH before a procedure, orthopaedic practices must also have the resources to handle the coordination of care effectively. Understanding how deficiencies in SDOH can impact communication workload would help support effective resource planning and equitable patient engagement strategies, particularly as more perioperative management takes place outside the hospital setting.QUESTIONS/PURPOSES(1) What are the differences in touchpoint utilization in patients who live in locations with varying Area Deprivation Index (ADI) scores, a surrogate measure for social deprivation? (2) Does social deprivation have an association with the length of stay (LOS) during primary total joint arthroplasty? (3) How are readmission rates and patient-reported outcome measures (PROMs) different in patients living in areas with varying degrees of social deprivation?METHODSIn this retrospective, comparative study, there were 92,801 patients who underwent primary, elective THA (43% [39,963]) or TKA (57% [52,837]) for osteoarthritis at one high-volume, urban, academic institution between January 2016 and December 2022. Of those, exclusions consisted of indications other than osteoarthritis (2% [1595]), no available ADI data (13% [12,302]), or loss to minimum 90-day postoperative follow-up and incomplete data (29% [26,836]). In all, 52,068 patients were included in the final analysis, with 43% (22,363) of patients undergoing primary THA and 57% (29,705) undergoing primary TKA. To determine the degree of social deprivation, the 2022 ADI was used and linked to patients' street addresses. Using the ADI national ranking from 1 to 100, with 1 representing the lowest level of disadvantage and 100 representing the highest level of disadvantage, patients were compared by ADI quartiles; Quartile 1 represented the least disadvantaged cohort and Quartile 4 represented the most disadvantaged cohort. Overall, the mean ± SD age was 66 ± 10 years, and the population consisted of 56% (29,333 of 52,068) women. Thirty-three percent (17,391 of 52,068) of patients were in ADI Quartile 1, 44% (22,944 of 52,068) were in Quartile 2, 17% (8650 of 52,068) were in Quartile 3, and 6% (3083 of 52,068) were in Quartile 4. The primary outcome measure was the number of touchpoints per patient, defined as the communication points (telephone or electronic messages) sent or received on behalf of the patient in relation to the total joint arthroplasty procedure. Touchpoints within the 30-day preoperative or 90-day postoperative periods of the primary THA or TKA were included. Secondary outcome measures included LOS, 90-day readmissions, and PROMs consisting of the Knee Injury and Osteoarthr
背景:尽管社会健康决定因素(SDOH)缺陷与原发性全髋关节置换术和全髋关节置换术后的不良临床结果有关,但其在围手术期沟通工作量中的作用仍不清楚。尽管在手术前适当识别和处理可修改的SDOH仍然是必要的,骨科实践也必须有资源来有效地处理护理协调。了解SDOH的缺陷如何影响沟通工作量,将有助于支持有效的资源规划和公平的患者参与策略,特别是在医院外进行更多围手术期管理的情况下。问题/目的(1)生活在不同地区的患者接触点利用的差异是什么?区域剥夺指数(ADI)是衡量社会剥夺的替代指标。(2)社会剥夺是否与初次全关节置换术的住院时间(LOS)有关?(3)生活在不同社会剥夺程度地区的患者再入院率和患者报告的预后指标(PROMs)有何不同?方法在这项回顾性比较研究中,2016年1月至2022年12月,在一个高容量的城市学术机构,有92,801例骨关节炎患者接受了原发性选择性THA(43%[39,963])或TKA(57%[52,837])。其中,排除包括骨关节炎以外的适应症(2%[1595]),无可用的ADI数据(13%[12,302]),或术后至少90天随访缺失和数据不完整(29%[26,836])。总共52,068例患者被纳入最终分析,其中43%(22,363)的患者接受了原发性THA, 57%(29,705)的患者接受了原发性TKA。为了确定社会剥夺的程度,使用了2022年的ADI,并将其与患者的街道地址联系起来。采用ADI国家排名从1到100,其中1代表最低的不利水平,100代表最高的不利水平,以ADI四分位数对患者进行比较;四分位数1代表最弱势群体,四分位数4代表最弱势群体。总体而言,平均±SD年龄为66±10岁,人口由56%(52,068人中29,333人)的女性组成。33%(52,068例中的17,391例)的患者属于ADI四分位数1,44%(52,068例中的22,944例)的患者属于四分位数2,17%(52,068例中的8650例)的患者属于四分位数3,6%(52,068例中的3083例)的患者属于四分位数4。主要结局指标是每位患者的接触点数量,定义为与全关节置换术相关的患者发送或接收的通信点(电话或电子信息)。包括原发性THA或TKA术前30天或术后90天的接触点。次要结局指标包括LOS、90天再入院率和PROMs,包括膝关节损伤和关节置换术骨关节炎结局评分(oos, JR)和髋关节残疾和关节置换术骨关节炎结局评分(HOOS, JR)。在接受THA和TKA的患者中,分别有34%(22,363例中有7627例)和35%(29,705例中有10,418例)获得HOOS、JR和kos、JR评分的变化。采用未调整和调整的二项回归模型来评估ADI四分位数与接触点数量的关系,通过接触点是传入还是输出来评估。结果在调整了年龄、性别、体重指数、种族和民族、手术年份等因素后,外向的、由员工发起的接触点比例随着社会剥夺程度的增加而增加。与四分位数1相比,ADI四分位数4的患者显示出最大的外向接触点增加(发病率比[IRR] 1.17[95%可信区间(CI) 1.11至1.25];P < 0.001)。对于每100个接触点发送给四分位数1的患者,大约有117个接触点发送给四分位数4的患者。然而,与四分位数1相比,四分位数4的接触点率最低(IRR 0.95 [95% CI 0.91至0.99];p = 0.01)。这意味着,每从处境最不利的四分位数患者那里获得100个接触点,就从处境最不利的四分位数患者那里获得大约95个接触点。四分位数4患者初次全关节置换术的平均±SD LOS为1.7±1.4天,而四分位数1患者的平均LOS为1.2±1.0天(p < 0.001)。随着剥夺程度的加重,当天出院和LOS < 24小时的比例逐步下降(p < 0.001)。与四分位数1的患者相比,四分位数4的患者当天出院率较低(7%[138 / 1894]对14% [1526 / 10623];p < 0.001)。四分位数4的患者90天再入院率较高,为4%(3083例中的111例),而四分位数1的患者再入院率最低,为3%(17391例中的460例)(p = 0.004)。 同样,再入院率随着剥夺程度的加重而逐渐增加。从完成术前和术后PROMs的患者中,在12个月时达到最小临床重要差异的患者比例在oos, JR (p = 0.32)和HOOS, JR (p = 0.67)的ADI四分位数中没有差异。结论:虽然ADI四分位数之间进出接触点的差异不大,但这些差异表明,实践可以使用一致的模式来告知基于公平的资源分配和有针对性的患者参与策略。骨科医生可以考虑社区水平的剥夺指数来预测沟通需求和围手术期支持。在护理障碍妨碍术后护理之前对来自更不利地区的患者进行定位至关重要。这可以通过灵活的术前教育、远程医疗、交通支持和预先确定的时间间隔的重点工作人员外展来实现。弱势地区的患者将受益于自助教育,以减轻传入的通信。未来的研究应该调查沟通工作量是否介导了剥夺指数和术后结果之间的关系,例如,对于来自弱势地区的患者来说,是否需要额外的工作人员发起的外诊,以达到与来自弱势社区的患者相当的PROM阈值。证据等级:III级,治疗性研究。
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引用次数: 0
What Substitution and Prediction Strategies Address the Challenge of an Unmeasurable C2-7 Cobb Angle? 什么替代和预测策略应对不可测量的C2-7 Cobb角的挑战?
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-07 DOI: 10.1097/CORR.0000000000003812
Zerui Qin, Yu Ran, Zongshuo Sha, Lingmin Wu, Haodong Xiong, Qianzi Zhao, Zhongze Li, Jinsong Chen, Dongran Han, Yixing Liu, Jinyu Li, Jiang Chen
<p><strong>Background: </strong>The C2-7 Cobb angle is an important parameter in evaluating cervical sagittal alignment, which is widely used for preoperative planning, identifying surgical indications, and postoperative assessment. However, this angle becomes unmeasurable in 28% to 49% of clinical radiographs because of poor visualization of the C7 inferior endplate, limiting treatment planning and radiographic follow-up in cervical alignment assessment. The C2-6 Cobb angle has been proposed as a substitute in previous research, but these studies were limited by small symptomatic cohorts from a single center and lacked both subgroup-specific and external validation. Furthermore, there is currently a lack of reference standards for the clinical use of the C2-6 Cobb angle, and no established machine-learning models are available to accurately predict the C2-7 Cobb angle.</p><p><strong>Questions/purposes: </strong>(1) Can the C2-6 Cobb angle serve as a reliable substitute for the C2-7 angle? (2) Can machine-learning models accurately predict the C2-7 Cobb angle?</p><p><strong>Methods: </strong>We conducted a retrospective, multicountry imaging study from January 2020 to January 2025, utilizing standing lateral cervical spine radiographs from a large hospital data set in China and public data sets from Vietnam and India. In China, 11,800 radiographs were initially screened. The inclusion criterion was cervical radiographs of sufficient clarity. The exclusion criterion was cervical radiographs with incomplete visualization of anatomic structures. Following these exclusions, 10,571 radiographs from China were included, comprising 10,000 standard standing lateral radiographs plus 284 implant and 287 flexion-extension radiographs. From the public data sets, 470 radiographs from Vietnam and 62 from India were reviewed, with no radiographs excluded. A total of 11,103 radiographs were available for final analysis. Key variables included demographics (age, sex), symptomatic status, implant status, and radiographic sagittal parameters derived from standing lateral views. Four orthopaedic specialists labeled keypoints on the original radiographs, including the corner points of C2 to C7 and the centroid of C2. An algorithm was employed for precise measurement of the C2-6 and C2-7 Cobb angles. The Pearson correlation coefficient was calculated to assess the strength of the correlation between the C2-6 and C2-7 Cobb angles, and a linear regression analysis was applied to derive a predictive equation for the C2-7 Cobb angle based on the C2-6 Cobb angle. Subsequently, the 10,000 standard Chinese standing lateral radiographs were randomly assigned to the training set (80%) and the testing set (20%). An independent validation set (n = 1103) was established to assess robustness, comprising 284 implant radiographs and 287 flexion-extension radiographs from China, together with 470 from Vietnam and 62 from India.</p><p><strong>Results: </strong>Correlation analysis dem
背景:C2-7 Cobb角是评价颈椎矢状位对准的重要参数,广泛用于术前规划、手术指征识别及术后评估。然而,由于C7下终板的可视性差,该角度在28%至49%的临床x线片中无法测量,限制了治疗计划和颈椎对中评估的影像学随访。在以前的研究中,C2-6 Cobb角被提出作为替代,但这些研究受到来自单一中心的小症状队列的限制,缺乏亚组特异性和外部验证。此外,目前缺乏临床使用C2-6 Cobb角的参考标准,也没有成熟的机器学习模型可以准确预测C2-7 Cobb角。问题/目的:(1)C2-6 Cobb角可以作为C2-7角的可靠替代品吗?(2)机器学习模型能否准确预测C2-7 Cobb角?方法:我们从2020年1月至2025年1月进行了一项回顾性的多国影像学研究,利用来自中国大型医院数据集和越南和印度公共数据集的站立侧位颈椎x线片。在中国,最初筛查了11800张x光片。纳入标准是宫颈x线片足够清晰。排除标准为解剖结构显示不完全的颈椎x线片。在这些排除之后,纳入了来自中国的10,571张x线片,包括10,000张标准站立侧位x线片,284张植入x线片和287张屈伸x线片。从公共数据集中,审查了来自越南的470张x光片和来自印度的62张x光片,没有排除任何x光片。共有11,103张x光片可供最后分析。关键变量包括人口统计学(年龄、性别)、症状状态、种植体状态和从站立侧位角度得出的x线矢状面参数。四名骨科专家在原始x线片上标记关键点,包括C2至C7的角点和C2的质心。采用一种精确测量C2-6和C2-7 Cobb角的算法。计算Pearson相关系数评价C2-6与C2-7 Cobb角的相关性强弱,并基于C2-6 Cobb角进行线性回归分析,推导出C2-7 Cobb角的预测方程。随后,将10000张标准中国立式侧位x线片随机分配到训练集(80%)和测试集(20%)。建立了一个独立的验证集(n = 1103)来评估稳健性,包括来自中国的284张种植体x线片和287张屈伸x线片,以及来自越南的470张和来自印度的62张。结果:相关分析显示,总体人群中C2-6和C2-7 Cobb角呈正相关(r = 0.92; p < 0.001)。结合C2-6 Cobb角和其他矢状面参数的机器学习模型在估计C2-7 Cobb角方面取得了很高的预测精度,其中Lasso回归表现最好(R2 = 0.93,平均绝对误差[MAE] = 2.57)。此外,在验证集中观察到较强的性能(R2 = 0.95, MAE = 3.21)。在男性群体的亚群分析中,线性模型的验证效果最好,R2 = 0.94, MAE = 2.52。结论:C2-6和C2-7 Cobb角在不同国家、体位和植入物中均有很强的相关性和高度可解释的线性回归结果,表明C2-6 Cobb角可作为影像学中C2-7 Cobb角的可靠替代品。进一步分析发现,在人群水平上,C2-6 Cobb角比C2-7 Cobb角小约6°,可作为临床评价中标准化解释的重要参考。机器学习模型在估计C2-7 Cobb角方面取得了很高的预测精度,其中表现最好的模型(Lasso回归)的MAE为2.57,为临床应用提供了另一种选择。为了方便临床使用,我们提供了一个免费的在线工具(http://c2-7cobbanglepredictionsystem.online),该工具将至少维护15年。证据等级:III级,诊断性研究。
{"title":"What Substitution and Prediction Strategies Address the Challenge of an Unmeasurable C2-7 Cobb Angle?","authors":"Zerui Qin, Yu Ran, Zongshuo Sha, Lingmin Wu, Haodong Xiong, Qianzi Zhao, Zhongze Li, Jinsong Chen, Dongran Han, Yixing Liu, Jinyu Li, Jiang Chen","doi":"10.1097/CORR.0000000000003812","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003812","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The C2-7 Cobb angle is an important parameter in evaluating cervical sagittal alignment, which is widely used for preoperative planning, identifying surgical indications, and postoperative assessment. However, this angle becomes unmeasurable in 28% to 49% of clinical radiographs because of poor visualization of the C7 inferior endplate, limiting treatment planning and radiographic follow-up in cervical alignment assessment. The C2-6 Cobb angle has been proposed as a substitute in previous research, but these studies were limited by small symptomatic cohorts from a single center and lacked both subgroup-specific and external validation. Furthermore, there is currently a lack of reference standards for the clinical use of the C2-6 Cobb angle, and no established machine-learning models are available to accurately predict the C2-7 Cobb angle.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Questions/purposes: &lt;/strong&gt;(1) Can the C2-6 Cobb angle serve as a reliable substitute for the C2-7 angle? (2) Can machine-learning models accurately predict the C2-7 Cobb angle?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a retrospective, multicountry imaging study from January 2020 to January 2025, utilizing standing lateral cervical spine radiographs from a large hospital data set in China and public data sets from Vietnam and India. In China, 11,800 radiographs were initially screened. The inclusion criterion was cervical radiographs of sufficient clarity. The exclusion criterion was cervical radiographs with incomplete visualization of anatomic structures. Following these exclusions, 10,571 radiographs from China were included, comprising 10,000 standard standing lateral radiographs plus 284 implant and 287 flexion-extension radiographs. From the public data sets, 470 radiographs from Vietnam and 62 from India were reviewed, with no radiographs excluded. A total of 11,103 radiographs were available for final analysis. Key variables included demographics (age, sex), symptomatic status, implant status, and radiographic sagittal parameters derived from standing lateral views. Four orthopaedic specialists labeled keypoints on the original radiographs, including the corner points of C2 to C7 and the centroid of C2. An algorithm was employed for precise measurement of the C2-6 and C2-7 Cobb angles. The Pearson correlation coefficient was calculated to assess the strength of the correlation between the C2-6 and C2-7 Cobb angles, and a linear regression analysis was applied to derive a predictive equation for the C2-7 Cobb angle based on the C2-6 Cobb angle. Subsequently, the 10,000 standard Chinese standing lateral radiographs were randomly assigned to the training set (80%) and the testing set (20%). An independent validation set (n = 1103) was established to assess robustness, comprising 284 implant radiographs and 287 flexion-extension radiographs from China, together with 470 from Vietnam and 62 from India.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Correlation analysis dem","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtue Ethics in a Value-driven World: Bringing a Knife to a Gunfight. 道德伦理在价值驱动的世界:带刀去枪战。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-02 DOI: 10.1097/corr.0000000000003822
Casey Jo Humbyrd
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引用次数: 0
CORR Insights®: Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes? CORR Insights®:糖尿病患者屈肌腱滑膜RAGE表达与腕管综合征相关吗?
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-02 DOI: 10.1097/CORR.0000000000003820
A Lee Osterman
{"title":"CORR Insights®: Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes?","authors":"A Lee Osterman","doi":"10.1097/CORR.0000000000003820","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003820","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor's Spotlight/Take 5: Patients With Nonanaphylactic Penicillin Allergy Are Not at Increased Risk of Allergic Events After Receiving Prophylactic Preoperative Cefazolin Prior to Closed Fracture Repair. 病例5:非过敏性青霉素过敏患者在闭合性骨折修复术前预防性使用头孢唑林后,过敏事件的风险不会增加。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-02 DOI: 10.1097/corr.0000000000003792
Seth S Leopold
{"title":"Editor's Spotlight/Take 5: Patients With Nonanaphylactic Penicillin Allergy Are Not at Increased Risk of Allergic Events After Receiving Prophylactic Preoperative Cefazolin Prior to Closed Fracture Repair.","authors":"Seth S Leopold","doi":"10.1097/corr.0000000000003792","DOIUrl":"https://doi.org/10.1097/corr.0000000000003792","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":"52 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cemented Fixation in Arthroplasty for Hip Fractures Does Not Increase Cardiopulmonary Complications: A Secondary Analysis of the HIP ATTACK Trial. 髋部骨折关节置换术中骨水泥固定不会增加心肺并发症:髋关节发作试验的二次分析。
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-01 Epub Date: 2025-08-12 DOI: 10.1097/CORR.0000000000003645
Christiaan H Righolt, Flavia K Borges, Jhase Sniderman, Thomas R Turgeon, P J Devereaux, Mohit Bhandari, Ernesto Guerra Farfan, Abdel-Rahman Lawendy, Ameen Patel, Vikas Tandon, Wojciech Szczeklik, Sandra Ofori, Valerie Harvey, Eric R Bohm, Gavin C A Wood
<p><strong>Background: </strong>Cemented fixation in arthroplasty to treat hip fractures is now widely recommended, but it is not universally used. Some surgeons may feel that the risk of bone cement implantation syndrome and its cardiopulmonary sequalae are too high, in part, because the evidence provides little detail on postoperative myocardial injury and other medical complications after cement use.</p><p><strong>Questions/purposes: </strong>We aimed to use data from the HIP ATTACK trial (an RCT in which patients with a hip fracture were randomized to accelerated time to surgery versus normal timing of surgery) for a secondary analysis to answer the following questions on arthroplasty for patients with hip fractures: (1) Are patients who undergo cemented hip arthroplasty for hip fractures more likely to experience cardiopulmonary events than patients who undergo uncemented hip arthroplasty? (2) Are patients who undergo cemented hip arthroplasty for hip fractures more likely to experience myocardial injury, identified by elevated troponin levels, than patients who undergo uncemented hip arthroplasty?</p><p><strong>Methods: </strong>We performed a post hoc analysis of the HIP ATTACK trial for a subset of patients who were treated with THA or hemiarthroplasty for a femoral neck fracture because the trial collected postoperative troponin levels to allow us to identify myocardial injury. The HIP ATTACK trial consisted of 2970 patients. We limited our source cohort to the 1049 patients who underwent hip arthroplasty and were not lost to follow-up (four patients who had undergone arthroplasty were lost to follow-up). We excluded two patients with unknown fixation and six patients with "other arthroplasty." We limited our analysis to femoral neck fractures, which excluded 75 more patients. Of the 966 patients who received hip arthroplasty, 61% (593) had cemented fixation. Patients with cemented fixation were older than patients with cementless fixation (median [IQR] 82 (74 to 88) versus 79 (71 to 86); p = 0.003). Race was self-reported by patients and differed between patients with cemented and cementless fixation. A higher proportion of patients who received cementless fixation had undergone THA (compared with hemiarthroplasty) than patients in the cemented fixation group (24% [91] versus 11% [66]; p < 0.001). We used logistic regression to estimate the association between cement use and a composite outcome consisting of all-cause mortality and various cardiopulmonary outcomes. We included cardiopulmonary outcomes possibly associated with bone cement implantation syndrome; there were only a small number of patients who had only nonsevere outcomes. We had 80% power to detect an OR of ≥ 1.6. We adjusted for all baseline differences between both groups except for anesthesia (as it was not associated with the outcome) and duration of surgery (as it is a function of cement use).</p><p><strong>Results: </strong>After controlling for age, sex, race, and re
背景:关节置换术中骨水泥固定治疗髋部骨折现在被广泛推荐,但并没有被普遍使用。一些外科医生可能会认为骨水泥植入综合征及其心肺后遗症的风险太高,部分原因是有关骨水泥使用后的术后心肌损伤和其他医学并发症的证据很少。问题/目的:我们的目的是使用来自髋关节攻击试验的数据(一项随机对照试验,髋部骨折患者被随机分为加速手术时间和正常手术时间)进行二次分析,以回答以下关于髋部骨折患者髋关节置换术的问题:(1)髋部骨折接受骨水泥髋关节置换术的患者是否比未接受骨水泥髋关节置换术的患者更容易发生心肺事件?(2)髋部骨折行骨水泥髋关节置换术的患者是否比未行骨水泥髋关节置换术的患者更容易发生心肌损伤(由肌钙蛋白水平升高确定)?方法:我们对一组接受髋关节置换术或半关节置换术治疗的股骨颈骨折患者进行了髋关节发作试验的事后分析,因为该试验收集了术后肌钙蛋白水平,使我们能够识别心肌损伤。髋关节发作试验包括2970名患者。我们将源队列限制在1049例接受了髋关节置换术且未丢失随访的患者(4例接受了髋关节置换术的患者丢失了随访)。我们排除了2例固定不明的患者和6例“其他关节置换术”患者。我们将分析局限于股骨颈骨折,排除了另外75例患者。在接受髋关节置换术的966例患者中,61%(593例)采用骨水泥固定。采用骨水泥固定的患者比不采用骨水泥固定的患者年龄大(中位[IQR] 82(74 ~ 88)比79 (71 ~ 86);P = 0.003)。种族由患者自我报告,并且在骨水泥和非骨水泥固定患者之间存在差异。与半关节置换术相比,接受无骨水泥固定的患者行THA的比例高于骨水泥固定组(24%[91]对11% [66];p < 0.001)。我们使用逻辑回归来估计水泥使用与由全因死亡率和各种心肺结局组成的复合结局之间的关系。我们纳入了可能与骨水泥植入综合征相关的心肺结局;只有少数患者只有非严重的结果。我们有80%的概率检测到OR≥1.6。我们调整了两组之间的所有基线差异,除了麻醉(因为它与结果无关)和手术持续时间(因为它是水泥使用的函数)。结果:在控制了年龄、性别、种族和相关合并症后,我们发现水泥的使用与90天复合结果的差异无关(OR 1.0[95%可信区间(CI) 0.7至1.4];p = 0.99)或1年(or 1.0 [95% CI 0.7 ~ 1.4]; p = 0.95)或术后第1天肌钙蛋白升高(or 1.4 [95% CI 1.0 ~ 1.9]; p = 0.06)。结论:髋关节置换术内固定治疗髋部骨折患者的心肺功能无明显差异。这些发现进一步支持了对髋部骨折患者在全髋关节置换术和半关节置换术中使用骨水泥股骨固定的建议。经验有限的外科医生应熟悉这些技巧。未来的研究应该评估骨水泥固定存在哪些障碍以及如何减轻这些障碍。证据等级:III级,治疗性研究。
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引用次数: 0
CORR Insights®: Cemented Fixation in Arthroplasty for Hip Fractures Does Not Increase Cardiopulmonary Complications: A Secondary Analysis of the HIP ATTACK Trial. CORR Insights®:髋关节置换术中骨水泥固定不会增加心肺并发症:髋关节发作试验的二次分析。
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-01 Epub Date: 2025-09-15 DOI: 10.1097/CORR.0000000000003694
Nicholas J Giori
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Clinical Orthopaedics and Related Research®
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