首页 > 最新文献

Clinical Orthopaedics and Related Research®最新文献

英文 中文
Letter to the Editor: Is Program Director Gender Associated With Gender Diversity Among Orthopaedic Surgery Residency Programs? 致编辑的信:矫形外科住院医师培训项目的性别多样性与项目主任的性别有关吗?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI: 10.1097/CORR.0000000000003175
Kimberly J Templeton
{"title":"Letter to the Editor: Is Program Director Gender Associated With Gender Diversity Among Orthopaedic Surgery Residency Programs?","authors":"Kimberly J Templeton","doi":"10.1097/CORR.0000000000003175","DOIUrl":"10.1097/CORR.0000000000003175","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: Electric Scooter-related Injuries Are Becoming More Frequent and Costly in Denver, CO. CORR Insights®:在科罗拉多州丹佛市,与电动滑板车有关的伤害事故越来越频繁,代价也越来越高。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-30 DOI: 10.1097/CORR.0000000000003232
Paul Edward Levin
{"title":"CORR Insights®: Electric Scooter-related Injuries Are Becoming More Frequent and Costly in Denver, CO.","authors":"Paul Edward Levin","doi":"10.1097/CORR.0000000000003232","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003232","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: Does the Application of Topical Vancomycin Reduce Surgical Site Infections in Spine Surgery? A Meta-analysis of Randomized Controlled Trials. CORR Insights®:局部应用万古霉素能否减少脊柱手术中的手术部位感染?随机对照试验的 Meta 分析。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-29 DOI: 10.1097/CORR.0000000000003243
Jose Chacon
{"title":"CORR Insights®: Does the Application of Topical Vancomycin Reduce Surgical Site Infections in Spine Surgery? A Meta-analysis of Randomized Controlled Trials.","authors":"Jose Chacon","doi":"10.1097/CORR.0000000000003243","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003243","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Patients With Dominant-side Distal Radius Fractures Have Greater Psychological Distress Than Those With Nondominant-side Fractures? 与非优势侧桡骨远端骨折患者相比,优势侧桡骨远端骨折患者的心理压力更大吗?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-29 DOI: 10.1097/CORR.0000000000003244
Hayati Kart, Erdoğdu Akça
<p><strong>Background: </strong>Distal radius fractures have a psychological impact on patients, with the pain and disability caused by these injuries potentially leading to psychological distress. It is not known whether dominant-side and nondominant-side distal radius fractures cause more psychological distress in patients.</p><p><strong>Questions/purposes: </strong>(1) Compared with patients who have distal radius fractures on the nondominant side, do patients with dominant-side fractures experience greater pain? (2) Do patients with dominant-side distal radius fractures have greater disability? (3) Do patients with dominant-side distal radius fractures have worse psychological adjustment? (4) What factors are associated with a worse quality of life mental component measure?</p><p><strong>Methods: </strong>This retrospective study was conducted by the departments of orthopaedics-traumatology and psychiatry in a multidisciplinary manner at our university hospital, which is a public hospital. The study included 172 patients with distal radius fractures who were treated nonoperatively. We excluded 2% (3 of 172) of patients who underwent surgery because of loss of reduction, 1% (2 of 172) of patients with bilateral distal radius fractures, and 9% (16 of 172) of patients who did not consent to participate in the study. After the exclusion of 12% (21 of 172) of ineligible patients, the study continued with 88% (151 of 172) of patients. Forty-six percent (70 of 151) of patients had dominant distal radius fractures and 54% (81 of 151) of patients had nondominant distal radius fractures. The evaluation was carried out face-to-face at the end of the sixth week of treatment in the orthopaedic outpatient clinic. The VAS score was used to assess pain (this score ranges from 0 to 10, where 0 represents no pain and 10 represents the worst pain, with a minimum clinically important difference [MCID] of 2), the QuickDASH was used to assess disability (ranges from 0 to 100, representing best to worst, with an MCID of 15.9), the Brief Adjustment Scale-6 (BASE-6) was used to assess psychological adjustment (ranges from 6 to 42, lower scores indicate better outcomes), and the SF-12 was used to assess quality of life (ranges from 0 to 100, representing worst to best, with an MCID of 5).</p><p><strong>Results: </strong>At cast removal, patients with dominant-side distal radius fractures had higher levels of pain (dominant VAS median [IQR] 4 [4], nondominant VAS median 2 [3], median difference 2; p = 0.005), but the difference was not clinically important. There were no differences in disability (dominant QuickDASH median 63.6 [21], nondominant Quick DASH median 59.1 [25], median difference 4.5; p = 0.20). Psychological adjustment was worse in patients with dominant-side fractures (dominant BASE-6 median 22.5 [24.3], nondominant BASE-6 median 15 [23.5], median difference 7.5; p = 0.004). After accounting for variables such as age, occupation, and gender, a better qual
背景:桡骨远端骨折会对患者的心理造成影响,这些损伤造成的疼痛和残疾可能会导致心理困扰。问题/目的:(1) 与非支配侧桡骨远端骨折患者相比,支配侧骨折患者的疼痛程度是否更严重? (2) 支配侧桡骨远端骨折患者的残疾程度是否更严重?(3) 优势侧桡骨远端骨折患者的心理适应能力是否更差?(4)哪些因素与生活质量心理成分测量结果较差有关?这项回顾性研究由我校公立医院的骨科-创伤科和精神科以多学科方式进行。研究包括 172 名接受非手术治疗的桡骨远端骨折患者。我们排除了2%(172例中的3例)因复位丧失而接受手术的患者、1%(172例中的2例)双侧桡骨远端骨折患者以及9%(172例中的16例)不同意参与研究的患者。在排除了 12%(172 例中的 21 例)不符合条件的患者后,88%(172 例中的 151 例)的患者继续参加了研究。46%的患者(151 例中的 70 例)为显性桡骨远端骨折,54%的患者(151 例中的 81 例)为非显性桡骨远端骨折。评估在骨科门诊治疗第六周结束时面对面进行。采用 VAS 评分来评估疼痛(该评分范围从 0 到 10,其中 0 代表无痛,10 代表最严重的疼痛,最小临床意义差异 [MCID] 为 2),采用 QuickDASH 评分来评估残疾(范围从 0 到 100,从最佳到最差,最小临床意义差异 [MCID] 为 15。9),简易适应量表-6(BASE-6)用于评估心理适应情况(范围在 6 到 42 之间,得分越低表示结果越好),SF-12 用于评估生活质量(范围在 0 到 100 之间,从最差到最好,MCID 为 5):拆除石膏时,显性侧桡骨远端骨折患者的疼痛程度更高(显性侧 VAS 中位数 [IQR] 4 [4],非显性侧 VAS 中位数 2 [3],中位数差异 2;P = 0.005),但这一差异在临床上并不重要。残疾程度没有差异(显性 QuickDASH 中位数为 63.6 [21],非显性 Quick DASH 中位数为 59.1 [25],中位数差异为 4.5;P = 0.20)。显性侧骨折患者的心理适应能力较差(显性侧 BASE-6 中位数为 22.5 [24.3],非显性侧 BASE-6 中位数为 15 [23.5],中位数差异为 7.5;P = 0.004)。在考虑年龄、职业和性别等变量后,生活质量较高的精神部分(SF-12 MCS)与较低的BASE-6(β = -0.67;p < 0.001)和非支配侧骨折(β = -0.16;p = 0.006)相关:结论:显侧桡骨远端骨折对患者的心理适应和生活质量有负面影响。显性桡骨远端骨折患者更容易出现心理障碍。未来的研究应评估在骨折时提供适当的咨询是否可以缓解显性侧桡骨远端骨折患者的心理障碍:证据等级:三级,治疗性研究。
{"title":"Do Patients With Dominant-side Distal Radius Fractures Have Greater Psychological Distress Than Those With Nondominant-side Fractures?","authors":"Hayati Kart, Erdoğdu Akça","doi":"10.1097/CORR.0000000000003244","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003244","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Distal radius fractures have a psychological impact on patients, with the pain and disability caused by these injuries potentially leading to psychological distress. It is not known whether dominant-side and nondominant-side distal radius fractures cause more psychological distress in patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Questions/purposes: &lt;/strong&gt;(1) Compared with patients who have distal radius fractures on the nondominant side, do patients with dominant-side fractures experience greater pain? (2) Do patients with dominant-side distal radius fractures have greater disability? (3) Do patients with dominant-side distal radius fractures have worse psychological adjustment? (4) What factors are associated with a worse quality of life mental component measure?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study was conducted by the departments of orthopaedics-traumatology and psychiatry in a multidisciplinary manner at our university hospital, which is a public hospital. The study included 172 patients with distal radius fractures who were treated nonoperatively. We excluded 2% (3 of 172) of patients who underwent surgery because of loss of reduction, 1% (2 of 172) of patients with bilateral distal radius fractures, and 9% (16 of 172) of patients who did not consent to participate in the study. After the exclusion of 12% (21 of 172) of ineligible patients, the study continued with 88% (151 of 172) of patients. Forty-six percent (70 of 151) of patients had dominant distal radius fractures and 54% (81 of 151) of patients had nondominant distal radius fractures. The evaluation was carried out face-to-face at the end of the sixth week of treatment in the orthopaedic outpatient clinic. The VAS score was used to assess pain (this score ranges from 0 to 10, where 0 represents no pain and 10 represents the worst pain, with a minimum clinically important difference [MCID] of 2), the QuickDASH was used to assess disability (ranges from 0 to 100, representing best to worst, with an MCID of 15.9), the Brief Adjustment Scale-6 (BASE-6) was used to assess psychological adjustment (ranges from 6 to 42, lower scores indicate better outcomes), and the SF-12 was used to assess quality of life (ranges from 0 to 100, representing worst to best, with an MCID of 5).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;At cast removal, patients with dominant-side distal radius fractures had higher levels of pain (dominant VAS median [IQR] 4 [4], nondominant VAS median 2 [3], median difference 2; p = 0.005), but the difference was not clinically important. There were no differences in disability (dominant QuickDASH median 63.6 [21], nondominant Quick DASH median 59.1 [25], median difference 4.5; p = 0.20). Psychological adjustment was worse in patients with dominant-side fractures (dominant BASE-6 median 22.5 [24.3], nondominant BASE-6 median 15 [23.5], median difference 7.5; p = 0.004). After accounting for variables such as age, occupation, and gender, a better qual","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Repetition-based Training in a High-fidelity Model Enhance Critical Trauma Surgical Skills Among Trainees and Attending Surgeons Equally? 高仿真模型中的重复训练能否同样提高受训者和主治外科医生的关键创伤外科技能?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-28 DOI: 10.1097/CORR.0000000000003225
Karolina A Serhan, Joshua A Kotler, Colin V Crickard, Julia N Zuppke, Shannon D Lorimer, Jennifer Sanville, Christopher S Smith
<p><strong>Background: </strong>The evolution of warfare has resulted in a surge of high-energy blast injuries predominantly involving the lower extremities. Once thought to impact only forward-deployed military, such mechanisms of injury are becoming a harsh reality even in civilian territory. Proficiency in surgical techniques for extremity damage control is vital for surgeons, regardless of specialty. To evaluate and train surgical residents and attending surgeons in critical limb-salvage techniques, Theater Hospital Operations Replication (THOR) has been proposed as a high-fidelity training platform to enhance extremity surgery teaching practices and assess proficiency in fasciotomy, vascular shunting, and knee-spanning external fixation in a simulated, resource-limited environment.</p><p><strong>Questions/purposes: </strong>Given the importance of proficiency and efficiency in surgeon ability to perform fasciotomies, vascular shunting, and placement of external fixators, in this study, we proposed two research questions: (1) Does repetition-based training within the THOR model improve surgeon knowledge and technical skill? (2) Are there differences in skill outcome when utilizing the THOR model based on surgical specialty (orthopaedic versus general) and/or level in training (attending versus resident)?</p><p><strong>Methods: </strong>This was an observational learning outcome study performed in the bioskills lab at a single institution, the Naval Medical Center Portsmouth, in which 26 surgeons completed a same-day course consisting of pretraining assessment, cadaver training on three damage-control surgery techniques in a high-fidelity THOR environment, and post-training assessment. The surgeons were either general surgeons or orthopaedic surgeons and consisted of both residents and attending surgeons. Subjects underwent a pretraining knowledge assessment, followed by two rounds of performing simulated surgery. The first round of surgery included guidance and instruction from board-certified orthopaedic surgeons. After a short break for the subjects to review the material, the second round was completed without instruction. To answer our first question of how repetition-based training impacts surgical skill, our metrics included: Objective Structured Assessment of Technical Skills (OSATS) scores (range 1 to 5, scored lowest to highest, where higher scores represent optimal skill performance), procedural accuracy, a 10-question knowledge assessment administered before and after training (scored 0 to 10, where higher scores represent competency of the anatomy and procedure steps), and total procedure time. To address our second question, data on demographic characteristics were collected on all participants, which included surgical specialty, year in training, and gender.</p><p><strong>Results: </strong>The general surgery residents' cohort demonstrated improvement in both mean ± SD OSATS scores (2.4 ± 0.7 before training versus 3.6 ± 0.6 aft
无论是在战时环境还是在民用领域,高效和熟练的干预都是控制患者发病率的关键。每项手术几分钟的差异就能对损害控制起到决定性作用,尤其是在骨科医生和普通外科医生必须同时进行血管分流、膝关节外固定和小腿四腔筋膜切开术的情况下。本研究的观察期为一天,因此无法提供有关长期技能或知识保留的信息。后续研究可以评估从初始培训到最终评估的时间对整体技能能力和知识的影响。
{"title":"Can Repetition-based Training in a High-fidelity Model Enhance Critical Trauma Surgical Skills Among Trainees and Attending Surgeons Equally?","authors":"Karolina A Serhan, Joshua A Kotler, Colin V Crickard, Julia N Zuppke, Shannon D Lorimer, Jennifer Sanville, Christopher S Smith","doi":"10.1097/CORR.0000000000003225","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003225","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The evolution of warfare has resulted in a surge of high-energy blast injuries predominantly involving the lower extremities. Once thought to impact only forward-deployed military, such mechanisms of injury are becoming a harsh reality even in civilian territory. Proficiency in surgical techniques for extremity damage control is vital for surgeons, regardless of specialty. To evaluate and train surgical residents and attending surgeons in critical limb-salvage techniques, Theater Hospital Operations Replication (THOR) has been proposed as a high-fidelity training platform to enhance extremity surgery teaching practices and assess proficiency in fasciotomy, vascular shunting, and knee-spanning external fixation in a simulated, resource-limited environment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Questions/purposes: &lt;/strong&gt;Given the importance of proficiency and efficiency in surgeon ability to perform fasciotomies, vascular shunting, and placement of external fixators, in this study, we proposed two research questions: (1) Does repetition-based training within the THOR model improve surgeon knowledge and technical skill? (2) Are there differences in skill outcome when utilizing the THOR model based on surgical specialty (orthopaedic versus general) and/or level in training (attending versus resident)?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was an observational learning outcome study performed in the bioskills lab at a single institution, the Naval Medical Center Portsmouth, in which 26 surgeons completed a same-day course consisting of pretraining assessment, cadaver training on three damage-control surgery techniques in a high-fidelity THOR environment, and post-training assessment. The surgeons were either general surgeons or orthopaedic surgeons and consisted of both residents and attending surgeons. Subjects underwent a pretraining knowledge assessment, followed by two rounds of performing simulated surgery. The first round of surgery included guidance and instruction from board-certified orthopaedic surgeons. After a short break for the subjects to review the material, the second round was completed without instruction. To answer our first question of how repetition-based training impacts surgical skill, our metrics included: Objective Structured Assessment of Technical Skills (OSATS) scores (range 1 to 5, scored lowest to highest, where higher scores represent optimal skill performance), procedural accuracy, a 10-question knowledge assessment administered before and after training (scored 0 to 10, where higher scores represent competency of the anatomy and procedure steps), and total procedure time. To address our second question, data on demographic characteristics were collected on all participants, which included surgical specialty, year in training, and gender.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The general surgery residents' cohort demonstrated improvement in both mean ± SD OSATS scores (2.4 ± 0.7 before training versus 3.6 ± 0.6 aft","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: Does the Extent of Tear Influence Pseudoparesis in Patients With Isolated Subscapularis Tears? CORR Insights®:撕裂程度是否会影响肩胛下肌孤立性撕裂患者的假性瘫痪?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-27 DOI: 10.1097/CORR.0000000000003240
Heath Patrick Gould
{"title":"CORR Insights®: Does the Extent of Tear Influence Pseudoparesis in Patients With Isolated Subscapularis Tears?","authors":"Heath Patrick Gould","doi":"10.1097/CORR.0000000000003240","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003240","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: Can Periprosthetic Joint Infection of Tumor Prostheses Be Controlled With Debridement, Antibiotics, and Implant Retention? CORR Insights®:能否通过清创、抗生素和植入物保留控制肿瘤假体的假体周围关节感染?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-27 DOI: 10.1097/CORR.0000000000003236
Daniel C Allison
{"title":"CORR Insights®: Can Periprosthetic Joint Infection of Tumor Prostheses Be Controlled With Debridement, Antibiotics, and Implant Retention?","authors":"Daniel C Allison","doi":"10.1097/CORR.0000000000003236","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003236","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone. CORR Insights®:两种现代生存预测工具(SORG-MLA 和 METSSS)在接受手术后放疗和单纯放疗局部治疗的无症状长骨转移患者中的应用比较。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-23 DOI: 10.1097/CORR.0000000000003226
Kwok Chuen Wong
{"title":"CORR Insights®: Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone.","authors":"Kwok Chuen Wong","doi":"10.1097/CORR.0000000000003226","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003226","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials. 双膦酸盐疗法能否降低骨质疏松症患者的总死亡率?随机对照试验的 Meta 分析。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-22 DOI: 10.1097/CORR.0000000000003204
Zhibin Lan, Xue Lin, Di Xue, Yang Yang, Muhammad Saad, Qunhua Jin

Background: For patients with osteoporosis, bisphosphonate therapy can reduce the risk of fractures, but its effect on reducing mortality remains unclear. Previous studies on this topic have produced conflicting results and generally have been too small to definitively answer the question of whether bisphosphonate therapy reduces mortality. Therefore, a meta-analysis may help us arrive at a more conclusive answer.

Questions/purposes: In a large meta-analysis of placebo-controlled randomized controlled trials (RCTs), we asked: (1) Does bisphosphonate use reduce mortality? (2) Is there a subgroup effect based on whether different bisphosphonate drugs were used (zoledronate, alendronate, risedronate, and ibandronate), different geographic regions where the study took place (Europe, the Americas, and Asia), whether the study was limited to postmenopausal female patients, or whether the trials lasted 3 years or longer?

Methods: We conducted a systematic review using multiple databases, including Embase, Web of Science, Medline (via PubMed), Cochrane Library, and ClinicalTrials.gov, with each database searched up to November 20, 2023 (which also was the date of our last search), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included randomized, placebo-controlled clinical trials with participants diagnosed with osteoporosis and receiving bisphosphonate treatment. We excluded papers posted to preprint servers, other unpublished work, conference abstracts, and papers that were registered on ClinicalTrials.gov but were not yet published. We collected 2263 records. After excluding records due to study type, study content not meeting the inclusion criteria, and duplicates, our meta-analysis included 47 placebo-controlled RCTs involving 59,437 participants. Data extraction, quality assessment, and statistical analyses were performed. The evaluation of randomized trials for potential bias was conducted using the revised Cochrane Risk of Bias tool. This assessment encompassed factors such as sequence generation, allocation concealment, subject blinding, outcome assessor blinding, incomplete outcome data, and reporting bias. Some studies did not provide explicit details regarding random sequence generation, leading to a high risk of selection bias. A few studies, due to their open-label nature, were unable to achieve double-blind conditions for both the subjects and the researchers, resulting in intermediate performance bias. Nevertheless, the overall study quality was high. Due to the low heterogeneity among the studies, as evidenced by the low statistical heterogeneity (that is, a low I2 statistic), we opted for a fixed-effects model, indicating that the effect size is consistent across the studies. In such cases, the fixed-effects model can provide more precise estimates. According to the results of the funnel plot, we did not find evi

背景:对于骨质疏松症患者来说,双膦酸盐疗法可以降低骨折风险,但其降低死亡率的效果仍不明确。以往有关该主题的研究结果相互矛盾,而且一般规模都太小,无法明确回答双膦酸盐疗法是否能降低死亡率的问题。因此,荟萃分析可能有助于我们得出更确切的答案:在一项对安慰剂对照随机对照试验(RCTs)进行的大型荟萃分析中,我们提出了以下问题:(1)使用双膦酸盐是否会降低死亡率?(2)根据是否使用了不同的双膦酸盐药物(唑来膦酸盐、阿仑膦酸盐、利塞膦酸盐和伊班膦酸盐)、研究发生的不同地理区域(欧洲、美洲和亚洲)、研究是否仅限于绝经后女性患者、试验是否持续了 3 年或更长时间,是否存在亚组效应?我们使用多个数据库进行了系统性综述,包括 Embase、Web of Science、Medline(通过 PubMed)、Cochrane Library 和 ClinicalTrials.gov,每个数据库的检索时间都截止到 2023 年 11 月 20 日(这也是我们最后一次检索的日期),并遵循了系统性综述和元分析首选报告项目(Preferred Reporting Items for Systematic Reviews and Meta-Analyses,PRISMA)指南。我们纳入了以确诊为骨质疏松症并接受双膦酸盐治疗的患者为对象的随机安慰剂对照临床试验。我们排除了发布在预印本服务器上的论文、其他未发表的作品、会议摘要以及在 ClinicalTrials.gov 上注册但尚未发表的论文。我们共收集到 2263 条记录。在排除了因研究类型、研究内容不符合纳入标准以及重复的记录后,我们的荟萃分析包括了 47 项安慰剂对照 RCT,涉及 59437 名参与者。我们进行了数据提取、质量评估和统计分析。采用修订版 Cochrane 偏倚风险工具对随机试验的潜在偏倚进行了评估。评估包括序列生成、分配隐藏、受试者盲法、结果评估者盲法、结果数据不完整以及报告偏倚等因素。有些研究没有提供有关随机序列生成的明确细节,因此选择偏倚风险较高。少数研究由于其开放标签的性质,无法实现受试者和研究人员的双盲条件,从而导致中等程度的表现偏倚。尽管如此,总体研究质量还是很高的。由于各研究之间的异质性较低,如低统计异质性(即低 I2 统计量)所示,我们选择了固定效应模型,这表明各研究的效应大小是一致的。在这种情况下,固定效应模型可以提供更精确的估计值。根据漏斗图的结果,我们没有发现发表偏倚的证据:结果:使用双膦酸盐并不能降低骨质疏松症患者的总体死亡风险(风险比为 0.95 [95% CI 0.88 至 1.03])。涉及不同双膦酸盐药物(唑来膦酸盐、阿仑膦酸盐、利塞膦酸盐和伊班膦酸盐)、地区(欧洲、美洲和亚洲)、不同人群(绝经后女性患者和其他患者)以及持续 3 年或更长时间的试验的亚组分析表明,使用双膦酸盐不会降低总体死亡率:根据我们的综合荟萃分析,有高质量的证据表明,对骨质疏松症患者进行双膦酸盐治疗,尽管能有效降低骨折风险,但并不能降低总死亡率。根据临床指南,为骨质疏松症患者开具双膦酸盐处方时应继续以降低骨折风险为首要考虑因素。需要进行长期研究,以调查延长治疗期对死亡率的潜在影响:证据级别:I级,治疗研究。
{"title":"Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials.","authors":"Zhibin Lan, Xue Lin, Di Xue, Yang Yang, Muhammad Saad, Qunhua Jin","doi":"10.1097/CORR.0000000000003204","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003204","url":null,"abstract":"<p><strong>Background: </strong>For patients with osteoporosis, bisphosphonate therapy can reduce the risk of fractures, but its effect on reducing mortality remains unclear. Previous studies on this topic have produced conflicting results and generally have been too small to definitively answer the question of whether bisphosphonate therapy reduces mortality. Therefore, a meta-analysis may help us arrive at a more conclusive answer.</p><p><strong>Questions/purposes: </strong>In a large meta-analysis of placebo-controlled randomized controlled trials (RCTs), we asked: (1) Does bisphosphonate use reduce mortality? (2) Is there a subgroup effect based on whether different bisphosphonate drugs were used (zoledronate, alendronate, risedronate, and ibandronate), different geographic regions where the study took place (Europe, the Americas, and Asia), whether the study was limited to postmenopausal female patients, or whether the trials lasted 3 years or longer?</p><p><strong>Methods: </strong>We conducted a systematic review using multiple databases, including Embase, Web of Science, Medline (via PubMed), Cochrane Library, and ClinicalTrials.gov, with each database searched up to November 20, 2023 (which also was the date of our last search), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included randomized, placebo-controlled clinical trials with participants diagnosed with osteoporosis and receiving bisphosphonate treatment. We excluded papers posted to preprint servers, other unpublished work, conference abstracts, and papers that were registered on ClinicalTrials.gov but were not yet published. We collected 2263 records. After excluding records due to study type, study content not meeting the inclusion criteria, and duplicates, our meta-analysis included 47 placebo-controlled RCTs involving 59,437 participants. Data extraction, quality assessment, and statistical analyses were performed. The evaluation of randomized trials for potential bias was conducted using the revised Cochrane Risk of Bias tool. This assessment encompassed factors such as sequence generation, allocation concealment, subject blinding, outcome assessor blinding, incomplete outcome data, and reporting bias. Some studies did not provide explicit details regarding random sequence generation, leading to a high risk of selection bias. A few studies, due to their open-label nature, were unable to achieve double-blind conditions for both the subjects and the researchers, resulting in intermediate performance bias. Nevertheless, the overall study quality was high. Due to the low heterogeneity among the studies, as evidenced by the low statistical heterogeneity (that is, a low I2 statistic), we opted for a fixed-effects model, indicating that the effect size is consistent across the studies. In such cases, the fixed-effects model can provide more precise estimates. According to the results of the funnel plot, we did not find evi","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORR Insights®: What Are the Functional, Radiographic, and Survivorship Outcomes of a Modified Cup-Cage Technique for Pelvic Discontinuity? CORR Insights®:骨盆不连的改良髋臼杯-骨盆笼技术的功能、影像学和存活率结果如何?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-08-20 DOI: 10.1097/CORR.0000000000003227
Michael D Ries
{"title":"CORR Insights®: What Are the Functional, Radiographic, and Survivorship Outcomes of a Modified Cup-Cage Technique for Pelvic Discontinuity?","authors":"Michael D Ries","doi":"10.1097/CORR.0000000000003227","DOIUrl":"https://doi.org/10.1097/CORR.0000000000003227","url":null,"abstract":"","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Orthopaedics and Related Research®
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1