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Editorial Comment: Selected Proceedings From the 2023 Bernese Hip Symposium. 编辑评论:2023 年伯尔尼髋关节研讨会论文集选编。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI: 10.1097/CORR.0000000000003213
Klaus-Arno Siebenrock
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引用次数: 0
Cochrane in CORR® : Opioid Agonist Treatment for People Who are Dependent on Pharmaceutical Opioids. CORR® 中的 Cochrane:阿片类药物依赖者的阿片类激动剂治疗。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1097/CORR.0000000000003202
Kim Madden
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引用次数: 0
CORR Insights®: How Does Radiographic Acetabular Morphology Change Between the Supine and Standing Positions in Asymptomatic Volunteers? CORR Insights®:无症状志愿者的髋臼形态在仰卧位和站立位之间有何变化?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-05-21 DOI: 10.1097/CORR.0000000000003135
Alpesh Kothari
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引用次数: 0
CORR Insights®: What Is the Influence of Femoral Version on Size, Tear Location, and Tear Pattern of the Acetabular Labrum in Patients With FAI? CORR Insights®:股骨型号对 FAI 患者髋臼盂唇的大小、撕裂位置和撕裂形态有何影响?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-03-14 DOI: 10.1097/CORR.0000000000003042
Nikolaos V Bardakos
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引用次数: 0
CORR Insights®: Are Current Survival Prediction Tools Useful When Treating Subsequent Skeletal-related Events From Bone Metastases? CORR Insights®:在治疗骨转移瘤的后续骨骼相关事件时,当前的生存预测工具是否有用?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-19 DOI: 10.1097/CORR.0000000000003077
Jose Chacon
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引用次数: 0
Does Periacetabular Osteotomy Change Sagittal Spinopelvic Alignment? 髋臼周围截骨术是否会改变矢状脊柱骨排列?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-02 DOI: 10.1097/CORR.0000000000003031
Peter Cirrincione, Nora Cao, Zachary Trotzky, Erikson Nichols, Ernest Sink
<p><strong>Background: </strong>There are few data on the impact of periacetabular osteotomy (PAO) on sagittal spinopelvic alignment. Prior studies have attempted to delineate the relationship by performing measurements on AP radiographs and using mathematical models to determine changes in postoperative pelvic tilt. This information is clinically significant to a surgeon when evaluating acetabular/pelvic position intraoperatively and understanding spinopelvic alignment changes postoperatively; therefore, radiographic changes from PAO should be described in more detail.</p><p><strong>Questions/purposes: </strong>In this study, we asked: (1) Does the performance of PAO result in consistent changes in spinopelvic alignment, as measured on EOS radiographs? (2) Does this differ for unilateral versus bilateral PAOs? (3) Does this differ in the setting of a mobile spine versus an immobile spine? (4) Does this differ based on preoperative pelvic tilt?</p><p><strong>Methods: </strong>Mean preoperative and at least 1-year postoperative (15 ± 8 months from surgery, minimum 11 months, maximum 65 months) EOS hip-to-ankle standing and sitting radiographs for 55 patients in a prospectively collected registry who underwent PAO with a single surgeon from January 1, 2019, to January 11, 2022, were measured for pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis, lateral center-edge angle, L1 pelvic angle, and pubic symphysis to the sacroiliac index. Normality was assessed and paired sample t-tests (normally distributed data) or Wilcoxon signed rank tests (not normally distributed data) were utilized to assess if any measurements changed from preoperative to postoperative. Patients were then divided based on whether they had unilateral or bilateral dysplasia and unilateral or bilateral surgery, and these subgroups were analyzed the same way as the entire cohort. Two more subgroups were then formed based on lumbar mobility, defined as a change in sitting-to-standing lumbar lordosis less or greater than 1 SD from the population mean preoperatively, and the subgroups were analyzed the same way as the entire cohort. Finally, two additional subgroups were formed, preoperative standing pelvic tilt less than 10° and more than 20°, and analyzed the same as the entire cohort.</p><p><strong>Results: </strong>For the entire cohort, the median (IQR) standing lateral-center edge angle increased 17°, from a median of 21° (10°) to a median of 38° (8° [95% confidence interval (CI) 16° to 20°; p < 0.001). The median sitting lateral center-edge angle increased 17°, from a median of 18° (8°) to a median of 35° (8° [95% CI 14° to 19°]; p < 0.001). Standing pelvic incidence increased from 50° ± 11° to 52° ± 12° (mean difference 2° [95% CI 1° to 3°]; p = 0.004), but there were no changes for other measured parameters. There were no changes in any of the spinopelvic parameters for patients with unilateral dysplasia receiving a unilateral PAO, but patients with bilateral dysplas
背景:关于髋臼周围截骨术(PAO)对矢状面骨盆对位的影响的数据很少。之前的研究试图通过对 AP X 光片进行测量,并使用数学模型来确定术后骨盆倾斜度的变化,从而界定两者之间的关系。这些信息对于外科医生在术中评估髋臼/骨盆位置以及术后了解脊柱骨盆对线变化具有重要的临床意义;因此,应更详细地描述 PAO 带来的影像学变化:在本研究中,我们提出了以下问题:(1) 根据 EOS X 光片的测量,PAO 是否会导致脊柱骨盆对线发生一致的变化? (2) 单侧 PAO 与双侧 PAO 是否存在差异?(3) 脊柱活动与脊柱不活动是否有差异? (4) 术前骨盆倾斜是否有差异?在2019年1月1日至2022年1月11日期间,对前瞻性收集的登记册中55名接受PAO手术的患者的平均术前和至少术后1年(术后15±8个月,最短11个月,最长65个月)EOS髋关节到踝关节的站立和坐位X光片进行测量,以了解骨盆入径、骨盆倾斜、骶骨斜度、腰椎前凸、外侧中心边缘角、L1骨盆角和耻骨联合到骶髂指数。对正态性进行评估,并使用配对样本 t 检验(正态分布数据)或 Wilcoxon 符号秩检验(非正态分布数据)来评估从术前到术后是否有任何测量值发生变化。然后根据单侧或双侧发育不良以及单侧或双侧手术情况对患者进行分组,这些分组的分析方法与整个组别相同。然后根据腰椎活动度(定义为坐位到站位腰椎前凸的变化与术前人群平均值相比小于或大于 1 SD)再划分出两个亚组,亚组的分析方法与整个人群相同。最后,又成立了两个亚组,即术前站立骨盆倾斜度小于 10° 和大于 20°,分析方法与整个组别相同:在整个队列中,站立侧中心边缘角度的中位数(IQR)增加了17°,从中位数21°(10°)增加到中位数38°(8°[95% 置信区间(CI)16°至20°;P < 0.001])。坐位侧边中心角中位数增加了 17°,从中位数 18°(8°)增至中位数 35°(8° [95% 置信区间 (CI) 14°至 19°];P <0.001)。站立时骨盆入射角从 50° ± 11° 增加到 52° ± 12°(平均差异为 2° [95% CI 1° 至 3°];p = 0.004),但其他测量参数没有变化。接受单侧 PAO 的单侧发育不良患者的脊柱骨盆参数没有任何变化,但接受双侧 PAO 的双侧发育不良患者的骨盆入射角从 57°(14°)增加到 60°(16°)(95% CI 1°到 5°;P = 0.02),耻骨联合至骶髂关节指数从 84 mm (24 mm) 降至 77 mm (23 mm) (95% CI -7° 至 -2°;P = 0.007)。术前腰椎可活动的患者矢状脊柱排列没有任何变化,但术前腰椎不可活动的患者术后出现了一些变化。站立时骨盆倾斜度小于10°的患者骨盆入射角中位数(IQR)增加了2°,从中位数43°(9°)增至45°(12° [95% CI 0.3°至4°];p = 0.03),但术后他们的矢状脊柱对齐参数没有发生任何其他变化。术前骨盆倾斜超过20°的患者的矢状脊柱参数没有发生任何变化:结论:PAO 增加了骨盆入射角,可能是因为髋关节中心前移。除双侧 PAO 外,其他脊柱骨盆参数在术后均无变化。此外,术前缺乏脊柱活动度的患者(表现为腰椎前凸在站立位和坐位之间的变化极小)在 PAO 术后可能会出现脊柱骨盆排列的多种变化,包括脊柱活动度的增加。这可能是因为增加髋臼覆盖后脊柱代偿性夹板减少,但还需要进一步研究,包括患者报告的结果:证据等级:三级,治疗性研究。
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引用次数: 0
Residency Diary: Caring for Other People's Children. 驻校日记:照顾别人的孩子
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.1097/CORR.0000000000003203
Lisa G M Friedman
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引用次数: 0
Low Rate of AVN and Complications in Unstable SCFE With Epiphyseal-metaphyseal Discontinuity After Treatment With a Modified Dunn Procedure. 采用改良邓恩手术治疗不稳定的 SCFE 伴有骺端-金属骺端不连续的患者,其 AVN 和并发症发生率较低。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-05-14 DOI: 10.1097/CORR.0000000000003123
Kai Ziebarth, Till D Lerch, Tilman Kaim, Joseph M Schwab, Simon D Steppacher, Moritz Tannast, Klaus A Siebenrock
<p><strong>Background: </strong>The risk of developing avascular necrosis (AVN) in the setting of an unstable slipped capital femoral epiphysis (SCFE) that is undergoing treatment with the modified Dunn procedure is not well understood. In addition, since the Loder classification of unstable is reportedly different than actual intraoperatively observed instability (that is, discontinuity between the femoral head epiphysis and proximal femoral metaphysis), the overall risk of developing AVN, as well as the potential complications of treatment of these patients with the modified Dunn procedure, are unknown.</p><p><strong>Questions/purposes: </strong>To evaluate the modified Dunn procedure for the treatment of patients with epiphyseal-metaphyseal discontinuity, we asked: (1) What was the survivorship free from AVN at 10 years? (2) What was the survivorship free from subsequent surgery and/or complications at 10 years? (3) What were the clinical and patient-reported outcome scores?</p><p><strong>Methods: </strong>In a retrospective analysis, we identified 159 patients (159 hips) treated with a modified Dunn procedure for SCFE between 1998 and 2020, of whom 97% (155 of 159) had documentation about intraoperatively observed epiphyseal-metaphyseal stability. Of those, 37% (58 of 155) of patients were documented to have intraoperatively observed epiphyseal-metaphyseal discontinuity and were considered eligible for inclusion, whereas 63% (97 of 155) had documented epiphyseal-metaphyseal stability and were excluded. No patients were lost to follow-up before the 2-year minimum. All patients were assessed for survival, but 7% (4 of 58) did not fill out our outcomes score questionnaire. This resulted in 93% (54 of 58) of patients who were available for outcome score assessment. Additionally, 50% (29 of 58) of patients had not been seen within the last 5 years; they are included, but we note that there is uncertainty about their status. The median (range) age at surgery was 13 years (10 to 16), and the sex ratio was 60% (35 of 58) male and 40% (23 of 58) female patients. Sixty-four percent (37 of 58) of patients were classified as acute-on-chronic, and 17% (10 of 58) of patients were classified as acute. Forty-seven percent (27 of 58) of patients presented with severe slips and 43% (25 of 58) of patients with moderate slips based on radiographic classification. All patients underwent surgical hip dislocation with the modified Dunn procedure to correct the slip deformity and provide stabilization. Complications and reoperations were assessed from a review of electronic medical records, and a Kaplan-Meier estimator was used to estimate survivorship free from complications and reoperations at 10 years. Clinical examination results and questionnaire responses were evaluated at minimum 2-year follow-up.</p><p><strong>Results: </strong>Kaplan-Meier survivorship free from AVN was 93% (95% CI 87% to 100%) at 10 years. Survivorship free from any reoperation was 75% (95
背景:目前还不太清楚正在接受改良邓恩手术治疗的不稳定股骨头骺滑脱(SCFE)患者发生血管坏死(AVN)的风险。此外,据报道,由于 Loder 对不稳定的分类与术中观察到的实际不稳定(即股骨头骨骺和股骨近端骨骺之间不连续)不同,因此这些患者在接受改良 Dunn 手术治疗时,发生 AVN 的总体风险以及潜在并发症尚不清楚:为了评估改良邓恩手术对骺端-骺端不连续患者的治疗效果,我们提出了以下问题:(1)10 年后无 AVN 的存活率是多少?(2)10 年后无后续手术和/或并发症的存活率如何?(3)临床和患者报告的结果评分如何?在一项回顾性分析中,我们确定了1998年至2020年间接受改良Dunn术治疗的159例SCFE患者(159髋),其中97%(159例中的155例)有术中观察到的骺板-骺端稳定性的记录。其中,37%的患者(155 例中的 58 例)记录有术中观察到的骺端-骺端不连续,符合纳入条件,而 63%的患者(155 例中的 97 例)记录有骺端-骺端稳定性,被排除在外。没有患者在最短 2 年随访期之前失去随访机会。所有患者都进行了存活评估,但有 7%(58 人中有 4 人)没有填写我们的结果评分问卷。因此,93% 的患者(58 例中的 54 例)可以接受结果评分评估。此外,有 50%(58 例中的 29 例)的患者在过去 5 年中未曾就诊;这些患者也包括在内,但我们注意到他们的状况并不确定。手术时的年龄中位数(范围)为 13 岁(10 到 16 岁),性别比例为 60%(58 人中有 35 名男性)和 40%(58 人中有 23 名女性)。64%的患者(58 例中的 37 例)被归类为急性-慢性,17%的患者(58 例中的 10 例)被归类为急性。根据放射学分类,47%的患者(58 例中的 27 例)为重度滑脱,43%的患者(58 例中的 25 例)为中度滑脱。所有患者都接受了髋关节脱位手术,采用改良邓恩手术矫正滑脱畸形并提供稳定。并发症和再手术情况通过查阅电子病历进行评估,并使用卡普兰-梅耶估计器估算10年后无并发症和再手术的存活率。在至少两年的随访中对临床检查结果和问卷答复进行评估:10 年后,无 AVN 的 Kaplan-Meier 存活率为 93%(95% CI 为 87% 至 100%)。10年后,无任何再次手术的存活率为75%(95% CI为64%至88%)。此外,10 年后无并发症(定义为出现 AVN、再次手术或 Sink II 级或以上并发症)的存活率为 57%(95% CI 为 45% 至 73%)。未发生 AVN 的患者的 Merle D'Aubigne Postel 评分中位数(范围)为 18(14 至 18),发生 AVN 的四名患者的 Merle D'Aubigne Postel 评分中位数(范围)为 12(6 至 16)(P < 0.001)。非 AVN 患者的改良哈里斯髋关节评分中位数为 100(74 至 100),而 AVN 患者的改良哈里斯髋关节评分中位数为 65(37 至 82)(P = 0.001)。非 AVN 队列的 HOOS 总分中位数为 95(50 至 100),AVN 队列的 HOOS 总分中位数为 53(40 至 82)(P = 0.002):结论:虽然改良邓恩手术在技术上具有挑战性,但本研究表明,在经验丰富的医生手中,已显示出骺端-骺端不连续的患者可以接受治疗,且发生 AVN 和后续手术的风险较低。建议将这些患者转诊给在该手术方面拥有丰富专业知识的专科医生,以改善患者的治疗效果。前瞻性的长期观察研究将有助于我们在术前识别这些高风险患者,并确定该手术的长期成功率:证据级别:IV级,治疗性研究。
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引用次数: 0
Arthroscopic Partial Meniscectomy for a Degenerative Meniscus Tear Is Not Cost Effective Compared With Placebo Surgery: An Economic Evaluation Based on the FIDELITY Trial Data. 关节镜下半月板部分切除术治疗退行性半月板撕裂与安慰剂手术相比不具成本效益:基于 FIDELITY 试验数据的经济评估。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1097/CORR.0000000000003094
Roope Kalske, Ali Kiadaliri, Raine Sihvonen, Martin Englund, Aleksandra Turkiewicz, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Pirjo Toivonen, Simo Taimela, Teppo L N Järvinen
<p><strong>Background: </strong>In patients with a degenerative tear of the medial meniscus, recent meta-analyses and systematic reviews have shown no treatment benefit of arthroscopic partial meniscectomy (APM) over conservative treatment or placebo surgery. Yet, advocates of APM still argue that APM is cost effective. Giving advocates of APM their due, we note that there is evidence from the treatment of other musculoskeletal complaints to suggest that a treatment may prove cost effective even in the absence of improvements in efficacy outcomes, as it may lead to other benefits, such as diminished productivity loss and reduced costs, and so the question of cost effectiveness needs to be answered for APM.</p><p><strong>Questions/purposes: </strong>(1) Does APM result in lower postoperative costs compared with placebo surgery? (2) Is APM cost-effective compared with placebo surgery?</p><p><strong>Methods: </strong>One hundred forty-six adults aged 35 to 65 years with knee symptoms consistent with a degenerative medial meniscus tear and no knee osteoarthritis according to the American College of Rheumatology clinical criteria were randomized to APM (n = 70) or placebo surgery (n = 76). In the APM and placebo surgery groups, mean age was 52 ± 7 years and 52 ± 7 years, and 60% (42 of 70) and 62% (47 of 76) of participants were men, respectively. There were no between-group differences in baseline characteristics. In both groups, a standard diagnostic arthroscopy was first performed. Thereafter, in the APM group, the torn meniscus was trimmed to solid meniscus tissue, whereas in the placebo surgery group, APM was carefully mimicked but no resection of meniscal tissue was performed; as such, surgical costs were the same in both arms and were not included in the analyses. All patients received identical postoperative care including a graduated home-based exercise program. At the 2-year follow-up, two patients were lost to follow-up, both in the placebo surgery group. Cost effectiveness over the 2-year trial period was computed as incremental net monetary benefit (INMB) for improvements in quality-adjusted life years (QALY), using both the societal (primary) and healthcare system (secondary) perspectives. To be able to consider APM cost effective, the CEA analysis should yield a positive INMB value. Nonparametric bootstrapping was used to assess uncertainty. Several one-way sensitivity analyses were also performed.</p><p><strong>Results: </strong>APM did not deliver lower postoperative costs, nor did it convincingly improve quality of life scores when compared with placebo surgery. From a societal perspective, APM was associated with € 971 (95% CI -2013 to 4017) higher costs and 0.015 (95% CI -0.011 to 0.041) improved QALYs over 2-year follow-up compared with placebo surgery. Both differences were statistically inconclusive (a wide 95% CI that crossed the line of no difference). Using the conventional willingness to pay (WTP) threshold of € 35,000 per Q
背景:对于内侧半月板退行性撕裂的患者,最近的荟萃分析和系统综述显示,关节镜下半月板部分切除术(APM)与保守治疗或安慰剂手术相比没有治疗效果。然而,APM 的拥护者仍然认为 APM 具有成本效益。我们注意到,在治疗其他肌肉骨骼疾病方面有证据表明,即使没有改善疗效,治疗也可能被证明具有成本效益,因为它可能带来其他益处,如减少生产力损失和降低成本,因此需要回答 APM 的成本效益问题。问题/目的:(1) 与安慰剂手术相比,APM 是否能降低术后成本?(2) 与安慰剂手术相比,APM 是否具有成本效益?根据美国风湿病学会的临床标准,146 名年龄在 35 岁至 65 岁之间、膝关节症状符合内侧半月板退行性撕裂且无膝关节骨关节炎的成年人被随机分配接受 APM(70 人)或安慰剂手术(76 人)。APM手术组和安慰剂手术组的平均年龄分别为52±7岁和52±7岁,男性参与者分别占60%(70人中的42人)和62%(76人中的47人)。组间基线特征无差异。两组患者均首先进行了标准诊断性关节镜检查。随后,在APM组中,撕裂的半月板被修剪为实心半月板组织,而在安慰剂手术组中,则仔细模仿APM,但不切除半月板组织;因此,两组的手术费用相同,未纳入分析。所有患者都接受了相同的术后护理,包括渐进式家庭锻炼计划。在为期两年的随访中,有两名患者失去了随访机会,均属于安慰剂手术组。2 年试验期间的成本效益是根据质量调整生命年(QALY)改善的增量净货币效益(INMB)计算得出的,采用了社会(主要)和医疗保健系统(次要)两个角度。为使 APM 具有成本效益,成本效益分析应得出正的 INMB 值。采用非参数引导法评估不确定性。此外,还进行了多项单向敏感性分析:结果:与安慰剂手术相比,APM 既没有降低术后成本,也没有令人信服地提高生活质量评分。从社会角度来看,与安慰剂手术相比,APM 在 2 年随访期间的成本增加了 971 欧元(95% CI -2013-4017),QALYs 提高了 0.015(95% CI -0.011-0.041)。这两项差异在统计学上都没有定论(95% CI 较宽,越过了无差异线)。如果采用传统的支付意愿(WTP)阈值,即每 QALY 35,000 欧元,则 APM 的 INMB 为负值 -460 欧元(95% CI -3757 - 2698)。在我们的分析中,只有当 WTP 临界值上升到每 QALY 65,000 欧元时,APM 才会带来正的 INMB。无论选择何种 WTP 临界值,较宽的 95% CI 都表明成本效益不确定:本研究的结果进一步支持了临床实践指南的建议,即在半月板退行性撕裂患者中不使用 APM。鉴于现有证据显示APM与非手术治疗或安慰剂手术相比没有益处或成本效益,未来的研究不太可能改变这一结论。
{"title":"Arthroscopic Partial Meniscectomy for a Degenerative Meniscus Tear Is Not Cost Effective Compared With Placebo Surgery: An Economic Evaluation Based on the FIDELITY Trial Data.","authors":"Roope Kalske, Ali Kiadaliri, Raine Sihvonen, Martin Englund, Aleksandra Turkiewicz, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Pirjo Toivonen, Simo Taimela, Teppo L N Järvinen","doi":"10.1097/CORR.0000000000003094","DOIUrl":"10.1097/CORR.0000000000003094","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In patients with a degenerative tear of the medial meniscus, recent meta-analyses and systematic reviews have shown no treatment benefit of arthroscopic partial meniscectomy (APM) over conservative treatment or placebo surgery. Yet, advocates of APM still argue that APM is cost effective. Giving advocates of APM their due, we note that there is evidence from the treatment of other musculoskeletal complaints to suggest that a treatment may prove cost effective even in the absence of improvements in efficacy outcomes, as it may lead to other benefits, such as diminished productivity loss and reduced costs, and so the question of cost effectiveness needs to be answered for APM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Questions/purposes: &lt;/strong&gt;(1) Does APM result in lower postoperative costs compared with placebo surgery? (2) Is APM cost-effective compared with placebo surgery?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;One hundred forty-six adults aged 35 to 65 years with knee symptoms consistent with a degenerative medial meniscus tear and no knee osteoarthritis according to the American College of Rheumatology clinical criteria were randomized to APM (n = 70) or placebo surgery (n = 76). In the APM and placebo surgery groups, mean age was 52 ± 7 years and 52 ± 7 years, and 60% (42 of 70) and 62% (47 of 76) of participants were men, respectively. There were no between-group differences in baseline characteristics. In both groups, a standard diagnostic arthroscopy was first performed. Thereafter, in the APM group, the torn meniscus was trimmed to solid meniscus tissue, whereas in the placebo surgery group, APM was carefully mimicked but no resection of meniscal tissue was performed; as such, surgical costs were the same in both arms and were not included in the analyses. All patients received identical postoperative care including a graduated home-based exercise program. At the 2-year follow-up, two patients were lost to follow-up, both in the placebo surgery group. Cost effectiveness over the 2-year trial period was computed as incremental net monetary benefit (INMB) for improvements in quality-adjusted life years (QALY), using both the societal (primary) and healthcare system (secondary) perspectives. To be able to consider APM cost effective, the CEA analysis should yield a positive INMB value. Nonparametric bootstrapping was used to assess uncertainty. Several one-way sensitivity analyses were also performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;APM did not deliver lower postoperative costs, nor did it convincingly improve quality of life scores when compared with placebo surgery. From a societal perspective, APM was associated with € 971 (95% CI -2013 to 4017) higher costs and 0.015 (95% CI -0.011 to 0.041) improved QALYs over 2-year follow-up compared with placebo surgery. Both differences were statistically inconclusive (a wide 95% CI that crossed the line of no difference). Using the conventional willingness to pay (WTP) threshold of € 35,000 per Q","PeriodicalId":10404,"journal":{"name":"Clinical Orthopaedics and Related Research®","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial and Ethnic Minorities Underrepresented in Pain Management Guidelines for Total Joint Arthroplasty: A Meta-analysis. 少数种族和族裔在全关节置换术疼痛管理指南中的代表性不足:一项 Meta 分析。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-03-18 DOI: 10.1097/CORR.0000000000003026
Katherine Merk, Nicholas C Arpey, Alba M Gonzalez, Katia E Valdez, Anna Cohen-Rosenblum, Adam I Edelstein, Linda I Suleiman
<p><strong>Background: </strong>Total joint arthroplasty aims to improve quality of life and functional outcomes for all patients, primarily by reducing their pain. This goal requires clinical practice guidelines (CPGs) that equitably represent and enroll patients from all racial/ethnic groups. To our knowledge, there has been no formal evaluation of the racial/ethnic composition of the patient population in the studies that informed the leading CPGs on the topic of pain management after arthroplasty surgery.</p><p><strong>Questions/purposes: </strong>Using papers included in the 2021 Anesthesia and Analgesia in Total Joint Arthroplasty Clinical Practice Guidelines and comparing them with US National census data, we asked: (1) What is the representation of racial/ethnic groups in randomized controlled trials compared with their representation in the US national population? (2) Is there a relationship between the reporting of racial/ethnic groups and year of data collection/publication, location of study, funding source, or guideline section?</p><p><strong>Methods: </strong>Participant demographic data (study year published, study type, guideline section, year of data collection, study site, study funding, study size, gender, age, and race/ethnicity) were collected from articles cited by this guideline. Studies were included if they were full text, were primary research articles conducted primarily within the United States, and if they reported racial and ethnic characteristics of the participants. The exclusion criteria included duplicate articles, articles that included the same participant population (only the latest dated article was included), and the following article types: systematic reviews, nonsystematic reviews, terminology reports, professional guidelines, expert opinions, population-based studies, surgical trials, retrospective cohort observational studies, prospective cohort observational studies, cost-effectiveness studies, and meta-analyses. Eighty-two percent (223 of 271) of articles met inclusion criteria. Our original literature search yielded 27 papers reporting the race/ethnicity of participants, including 24 US-based studies and three studies conducted in other countries; only US-based studies were utilized as the focus of this study. We defined race/ethnicity reporting as the listing of participants' race or ethnicity in the body, tables, figures, or supplemental data of a study. National census information from 2000 to 2019 was then used to generate a representation quotient (RQ), which compared the representation of racial/ethnic groups within study populations to their respective demographic representation in the national population. An RQ value greater than 1 indicates an overrepresented group and an RQ value less than 1 indicates an underrepresented group, relative to the US population. Primary outcome measures of RQ value versus time of publication for each racial/ethnic group were evaluated with linear regression anal
背景:全关节置换术旨在改善所有患者的生活质量和功能预后,主要是通过减轻他们的疼痛。这一目标要求临床实践指南(CPG)能公平地代表所有种族/民族群体的患者,并让他们参与其中。据我们所知,在有关关节成形术后疼痛管理主题的主要 CPGs 的研究中,尚未对患者人群的种族/民族构成进行正式评估:利用 2021 年《全关节成形术麻醉与镇痛临床实践指南》中收录的论文,并将其与美国全国人口普查数据进行比较,我们提出了以下问题:(1) 随机对照试验中种族/民族群体的代表性与他们在美国全国人口中的代表性相比如何?(2)种族/民族群体的报告与数据收集/发布年份、研究地点、资金来源或指南章节之间是否存在关系?从本指南引用的文章中收集参与者的人口统计学数据(研究发表年份、研究类型、指南章节、数据收集年份、研究地点、研究资金、研究规模、性别、年龄和种族/民族)。如果研究为全文、主要在美国境内进行的主要研究文章,并且报告了参与者的种族和民族特征,则纳入研究。排除标准包括重复文章、包含相同参与人群的文章(仅纳入日期最近的文章)以及以下文章类型:系统综述、非系统综述、术语报告、专业指南、专家意见、基于人群的研究、外科试验、回顾性队列观察研究、前瞻性队列观察研究、成本效益研究和荟萃分析。82%的文章(271 篇文章中的 223 篇)符合纳入标准。我们通过原始文献检索获得了 27 篇报告参与者种族/族裔的论文,其中包括 24 篇美国研究和 3 篇在其他国家进行的研究;本研究只关注美国研究。我们将种族/族裔报告定义为在研究报告的正文、表格、数字或补充数据中列出参与者的种族或族裔。然后,我们利用 2000 年至 2019 年的全国人口普查信息生成代表商数(RQ),将研究人群中种族/民族群体的代表性与他们各自在全国人口中的代表性进行比较。相对于美国人口,RQ 值大于 1 表示群体代表性过高,小于 1 表示群体代表性不足。通过线性回归分析评估了每个种族/民族群体的RQ值与发表时间的关系,并通过卡方分析对种族报告和稿件参数进行了分析:结果: 两项美国研究独立报告了种族和人种。在 24 项报告种族/族裔的美国研究中,黑人参与者的总体 RQ 为 0.70,西班牙裔参与者为 0.09,美国印第安人/阿拉斯加原住民为 0.1,夏威夷原住民/太平洋岛民为 0,亚裔参与者为 0.08,白人参与者为 1.37。与美国全国人口相比,白人参与者的比例偏高 37%,黑人参与者的比例偏低 30%,西班牙裔参与者的比例偏低 91%,亚裔参与者的比例偏低 92%,美国印第安人/阿拉斯加原住民的比例偏低 90%,夏威夷太平洋岛民的比例几乎为零。通过卡方分析,学术界、工业界和双重资助来源的研究在种族/族裔报告方面存在差异(χ2 = 7.449; p = 0.02)。基于美国和非基于美国的研究在种族/族裔报告方面也存在差异(χ2 = 36.506; p < 0.001),基于美国的研究中有 93% (27 项中的 25 项)报告了种族,而非基于美国的研究中仅有 7%(27 项中的 2 项)报告了种族。最后,种族/民族报告与数据收集年份或引用的指南章节之间没有关系:2021年《全关节成形术中的麻醉与镇痛临床实践指南》提供了以证据为基础的建议,反映了骨科手术的现行标准,但与少数种族/族裔在美国人口中所占比例相比,这些指南所依据的研究绝大多数未充分登记和报告少数种族/族裔。由于这些因素会影响镇痛剂的使用,继续忽视这些因素可能会使 TJA 术后结果的不平等永久化。
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Clinical Orthopaedics and Related Research®
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