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CORR Insights®: Periacetabular Resection for Bone Tumors: Is There Still a Role for Massive Allograft-prosthesis Composite Reconstructions? CORR Insights®:髋臼周围骨肿瘤切除术:大量同种异体移植物-假体复合重建仍然有作用吗?
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-21 DOI: 10.1097/CORR.0000000000003798
Charles A C Villamin
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引用次数: 0
Letter to the Editor: What Is the Probability of Radial Nerve Recovery After Surgical Repair of Humerus Fractures Accounting for Time Since Injury? 致编辑:肱骨骨折手术修复后桡神经恢复的概率占伤后时间的多少?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-20 DOI: 10.1097/corr.0000000000003829
Christoph A Schroen
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引用次数: 0
How Does Traumatic Hand Injury Impact Patients in a Safety-net Healthcare System? A Mixed Methods Study. 外伤性手部损伤如何影响安全网医疗保健系统中的患者?混合方法研究。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-20 DOI: 10.1097/corr.0000000000003826
Robin T Higashi,Jessica Lee,Yadira Hernandez,Marisel Pontón,Joshua M Liao,Kyle C Cross,Jessica I Billig
BACKGROUNDTraumatic hand injuries can result in substantial harms to patients' functional abilities and financial health, disproportionately affecting individuals who are of working age, low income, and uninsured. However, little is known about how patients and their families cope with the functional limitations and economic consequences that follow, and how these injuries affect patients' mental and emotional health. Exploring clinician and staff perceptions about the impact of traumatic hand injuries on patients may provide insight into how to help address the various burdens patients face.QUESTIONS/PURPOSESIn this paper, we aimed to explore the following questions: (1) What is the impact of a traumatic hand injury on patients' financial health? (2) How does a traumatic hand injury affect patients' physical health and disability? (3) What kind of toll does a traumatic hand injury take on patients' emotional and mental health? (4) What health system challenges function as additional stressors after a traumatic hand injury?METHODSThis descriptive study consisted of surveys and semistructured interviews. We recruited patients from an outpatient hand surgery clinic at a safety-net hospital in a southern US city. Eligible patients were English- or Spanish-speaking, age 18 years or older, who presented to the clinic after a traumatic hand injury. Between January and April 2025, we invited patients to participate in three surveys that assessed financial burden and upper extremity disability: the Comprehensive Score for Financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT), the DASH questionnaire, and the InCharge Financial Distress/Financial Well-Being Scale. Of 94 surveys offered, 88% (83) of surveys were completed. The mean ± SD patient age was 38 ± 13 years. Forty-five percent (37 of 83) of participants spoke English, 55% (46 of 83) spoke Spanish, 82% (68 of 83) identified as Hispanic or Latino (any race), 70% (58 of 83) were male, and 58% (48 of 83) relied on the safety-net institution's county charity program for coverage of medical expenses. We completed 26 interviews with patients and 10 interviews with clinicians and staff (three physicians, three clinical staff, one nonclinical staff, and three finance staff), each lasting a median (range) of 24 minutes (13 to 54), while 11 patients and four clinicians and staff declined to participate because of lack of time or interest. Among interview participants, the mean ± SD participant age was 39 ± 15 years. Fifty-four percent (14 of 26) spoke English, 58% (15 of 26) identified as Hispanic or Latino (any race), 65% (17 of 26) were male, and 42% (11 of 26) relied on the county charity program. All statistical analyses were performed using R, version 4.5.0, with p < 0.05. A convenience sample of clinic patients was invited to participate in semistructured interviews, as was a purposive sample of clinicians and staff. Eligible clinicians and staff were those who had been employ
背景:外伤性手部损伤会对患者的功能能力和财务健康造成严重损害,尤其对处于工作年龄、低收入和无保险的个体造成严重影响。然而,对于患者及其家属如何应对功能限制和随之而来的经济后果,以及这些伤害如何影响患者的精神和情感健康,人们知之甚少。探索临床医生和工作人员对创伤性手部损伤对患者影响的看法,可以为如何帮助解决患者面临的各种负担提供见解。问题/目的本研究旨在探讨以下问题:(1)外伤性手部损伤对患者财务健康的影响是什么?(2)外伤性手部损伤对患者身体健康和残疾的影响?(3)外伤性手外伤对患者的情绪和心理健康有怎样的影响?(4)外伤性手部损伤后,哪些卫生系统挑战会成为额外的压力源?方法描述性研究包括问卷调查和半结构化访谈。我们从美国南部城市的一家安全网医院的门诊手外科诊所招募了患者。符合条件的患者是说英语或西班牙语,年龄在18岁或以上,在创伤性手部损伤后就诊的患者。在2025年1月至4月期间,我们邀请患者参加了三项评估经济负担和上肢残疾的调查:慢性疾病治疗财务毒性-功能评估综合评分(COST-FACIT), DASH问卷和InCharge财务困境/财务健康量表。在提供的94份调查中,88%(83份)的调查已完成。患者平均年龄为38±13岁。45%(83人中37人)的参与者说英语,55%(83人中46人)说西班牙语,82%(83人中68人)被认定为西班牙裔或拉丁裔(任何种族),70%(83人中58人)是男性,58%(83人中48人)依靠安全网机构的县慈善计划来支付医疗费用。我们完成了26次患者访谈和10次临床医生和工作人员访谈(3名医生、3名临床工作人员、1名非临床工作人员和3名财务人员),每次访谈持续的中位数(范围)为24分钟(13至54分钟),而11名患者和4名临床医生和工作人员因缺乏时间或兴趣而拒绝参与。在访谈参与者中,平均±SD参与者年龄为39±15岁。54%(26人中有14人)说英语,58%(26人中有15人)是西班牙裔或拉丁裔(任何种族),65%(26人中有17人)是男性,42%(26人中有11人)依靠县慈善计划生活。采用4.5.0版本R进行统计分析,p < 0.05。一个方便的门诊病人样本被邀请参加半结构化访谈,作为临床医生和工作人员的目的样本。符合条件的临床医生和工作人员是那些在安全网工作至少1年的人。在2024年8月至10月期间,用英语和西班牙语进行了采访,并进行了录音。在定性数据收集过程中,采访者使用快速数据分析矩阵记录调查结果,在数据收集结束时,我们进行主题内容分析,以更深入地分析调查结果,选择范例引用,并促进解释。结果调查数据显示,22%(83名患者中的18名)的患者在创伤性手部损伤后报告了高水平的财务毒性,定义为成本- facit评分< 23。接受采访的患者谈到了他们的受伤如何影响了他们支付杂货、家庭账单和娱乐活动的能力。每个人都分享了不同的应对策略来应对这些财务挑战,比如依靠他们的社交网络或找兼职。我们发现65%(83名患者中的54名)的患者在受伤后报告了严重的上肢残疾,这导致了他们工作或日常活动能力的限制。54%的患者(54人中有29人)接受了共同支付的慈善护理。病人的叙述还描述了他们的经济负担和残疾对他们及其周围亲人的心理健康的影响。临床医生、工作人员和患者报告了卫生系统面临的共同挑战,特别是缺乏适当和有效的财务流程,无法帮助患者获得社会支持工具和资金。结论:我们的研究结果表明,除了经济上的毒性外,外伤性手损伤还会给安全网机构的患者及其家庭成员带来一系列情感和日常生活方面的挑战,这些挑战对他们的幸福感的影响远远超出了伤害期。 这些发现表明,医疗保健系统需要加强术后社会服务支持的强度和可持续性,包括潜在的使用正在进行的社会服务筛查工具和转介到社区组织。证据等级:II级,治疗性研究。
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引用次数: 0
The Intersection of Orthopaedic Culture and Gender: Too Confident. 骨科文化与性别的交集:过于自信。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-20 DOI: 10.1097/corr.0000000000003824
Debra Zillmer
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引用次数: 0
Machine Learning-driven Probability Calculators Can Accurately Predict 1-year Mortality After Proximal Humerus Fractures in Patients Over the Age of 65 Years. 机器学习驱动的概率计算器可以准确预测65岁以上患者肱骨近端骨折后1年内的死亡率。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-16 DOI: 10.1097/corr.0000000000003828
Stijn R J Mennes,Sebastian Engbers,Bjarty L Garcia,Reinier W A Spek,Roelina Munnik-Hagewoud,Rutger G Zuurmond,Ruurd L Jaarsma,Job N Doornberg,Michel P J van den Bekerom,
BACKGROUNDProximal humerus fractures (PHFs) in patients ≥ 65 years of age are associated with increased risk of death in the months after injury. Controversy exists regarding the preferred treatment strategy in these patients, and operative treatment is associated with high complication and reoperation rates. Machine learning (ML)-driven probability calculators for mortality prediction therefore may be valuable during shared decision-making for surgeons and patients.QUESTIONS/PURPOSES(1) To develop ML algorithms to predict 1-year mortality in patients ≥ 65 years of age. (2) To externally validate all algorithms on a geographically distinct patient population. (3) To create an easy-to-use, online calculator that can be used by surgeons at the point of care to enable more informed decision-making.METHODSThis study identified 5114 potentially eligible patients age ≥ 65 years who presented to our two hospitals in Holland (one is a Level 1 trauma center and one is a Level 2 trauma center) between January 2016 and December 2023. Of those, we considered 3488 patients eligible because they were ≥ 65 years of age and had a first-time PHF. Based on that, 86% (2999) were included for the analysis. A further 10% (334) were excluded because of misdiagnosis, bilateral PHFs, or a history of previous PHFs. Finally, 4% (155) had an irretrievable mortality status or had incomplete data sets. Data on 24 potential factors associated with increased mortality after PHFs were collected. Surgical or nonoperative treatment were not included as the aim was to predict 1-year mortality at the moment a PHF was sustained, before a treatment choice had been made. Therefore, excluding treatment modalities does not limit the intended use as a pretreatment risk estimation model. Four ML algorithms were developed: logistic regression, extreme gradient boosting machine (XGBoost), random forest, and LightGBM. The ML algorithms were trained and internally validated on patients from the first hospital (59% [1768 of 2999]) and externally validated on a geographically distinct group of patients from the second hospital (41% [1231 of 2999]). The mean ± SD age in the training cohort was 77 ± 8 years, and it was 76 ± 8 years in the external validation set; 79% (2383 of 2999) of patients were female. The overall 1-year mortality rate was 11% (325 of 2999). Performance was assessed with discrimination and calibration curves, and overall performance was assessed using the Brier score. Discrimination was assessed with the c-statistic: the area under the receiver operating characteristic curve. The c-statistic ranges from 0.50 to 1.0, with 1.0 indicating perfect discriminating ability. Calibration was assessed by plotting the agreement between the observed outcome and predicted probability, and the intercept and slope were determined. The plot's intercept indicates whether predictions were too high (intercept < 0) or too low (intercept > 0). The slope reflects either overfitting (predictions to
背景:≥65岁的患者肱骨近端骨折(phf)与损伤后几个月内死亡风险增加相关。对于这些患者的首选治疗策略存在争议,手术治疗与高并发症和再手术率相关。因此,机器学习(ML)驱动的死亡率预测概率计算器在外科医生和患者共同决策时可能很有价值。(1)开发ML算法来预测≥65岁患者的1年死亡率。(2)在地理上不同的患者群体上对所有算法进行外部验证。(3)创建一个易于使用的在线计算器,供外科医生在护理点使用,以实现更明智的决策。方法:在2016年1月至2023年12月期间,在荷兰的两家医院(一家是一级创伤中心,一家是二级创伤中心)就诊的5114名年龄≥65岁的潜在符合条件的患者。其中,我们认为3488例患者符合条件,因为他们年龄≥65岁且首次发生PHF。在此基础上,86%(2999)被纳入分析。另有10%(334例)因误诊、双侧PHFs或既往PHFs病史而被排除。最后,4%(155例)的死亡率不可挽回或数据集不完整。收集了与phf后死亡率增加相关的24个潜在因素的数据。手术或非手术治疗不包括在内,因为其目的是在治疗选择之前预测PHF持续的1年死亡率。因此,排除治疗方式并不限制其作为预处理风险评估模型的预期用途。开发了四种机器学习算法:逻辑回归、极端梯度增强机(XGBoost)、随机森林和LightGBM。机器学习算法在第一家医院的患者身上进行了训练和内部验证(59%[2999的1768人]),在第二家医院的地理位置不同的患者组上进行了外部验证(41%[2999的1231人])。训练组的平均±SD年龄为77±8岁,外部验证组的平均±SD年龄为76±8岁;2999例患者中女性占79%(2383例)。总的1年死亡率为11%(2999例中有325例)。用判别曲线和校准曲线评估其表现,用Brier评分评估其总体表现。用c统计量(即受者工作特征曲线下的面积)评价鉴别性。c统计量在0.50 ~ 1.0之间,1.0表示判别能力较好。通过绘制观测结果与预测概率之间的一致性来评估校准,并确定截距和斜率。图的截距表明预测是过高(截距< 0)还是过低(截距> 0)。斜率反映了过拟合(预测过于极端,斜率> 1)或欠拟合(预测不够极端,斜率< 1)。一个理想的预测模型具有截距为0,斜率为1的校准曲线。Brier分数反映了整体表现,是判别和校准的综合表现。0分代表完美预测,1分代表最差预测。阴性和阳性预测值也进行了评估。对于内部验证,执行五次交叉验证以防止数据泄漏,并使用1000次引导来确保稳健的结果并解释乐观主义。交叉验证需要将训练集划分为子集(五个),然后在四个集合上训练模型。第五,看不见的集合用于内部验证,防止高估模型性能。对于外部验证,仅使用1000倍的引导来评估性能,以确保稳健的结果和正确的乐观主义。结果算法与c-statistics(判别能力)相似,内部验证的范围为0.80 ~ 0.81(95%置信区间[CI] 0.72 ~ 0.86),外部验证的范围为0.83 ~ 0.85 (95% CI 0.81 ~ 0.86)。c统计量超过0.80被认为是老年创伤人群死亡率预测模型的强大性能。在评估的模型中选择逻辑回归作为最佳模型,因为它具有足够的校准和可解释性。强校正确保模型不受过拟合或欠拟合的影响,也不会预测过高或过低。逻辑回归是可解释的,因为它需要较少的预测因子并提供可理解的系数。阴性预测值为0.91 (95% CI 0.90至0.92),阳性预测值为0.66 (95% CI 0.54至0.81),与死亡率相关性最强的因素是偏瘫、骨折前在医疗机构的居住和心力衰竭。 本研究开发并外部验证了一种机器学习驱动的预测模型,该模型可以准确地提供单个患者的1年死亡风险。医生可以在共同决策和患者咨询时使用这种预测预后的工具,因为它在考虑phf治疗方案时为患者和家属提供了现实的期望,从而增强了知情同意过程。预测工具被整合到一个免费的web应用程序中,可以通过https://bjarty.shinyapps.io/mortality_app/.LEVEL OF EVIDENCELevel III,治疗性研究访问。
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引用次数: 0
CORR Synthesis: How Should PROM Thresholds Be Determined and Interpreted to Reflect Clinically Meaningful Change in Orthopaedic Surgery? CORR综合:如何确定和解释胎膜早破阈值以反映骨科手术临床有意义的变化?
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-16 DOI: 10.1097/corr.0000000000003815
Neel Vallurupalli,Benjamin Padon,Jie J Yao
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引用次数: 0
Letter to the Editor: Editorial: Fully Compromised, but Thanks All the Same to Our Peer Reviewers. 致编辑的信:社论:完全妥协,但同样感谢我们的同行审稿人。
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-15 DOI: 10.1097/CORR.0000000000003830
Joseph Bernstein
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引用次数: 0
Your Best Life: Care for Your Brain and Put Your Phone Away! 你最好的生活:照顾好你的大脑,把你的手机收起来!
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-09 DOI: 10.1097/CORR.0000000000003823
John D Kelly
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引用次数: 0
Higher Area Deprivation Index Is Associated With Greater Practice-initiated Perioperative Communication Workload in Patients With Primary Total Joint Arthroplasty. 在初次全关节置换术患者中,较高的区域剥夺指数与更大的实践发起的围手术期沟通工作量相关。
IF 4.2 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-08 DOI: 10.1097/corr.0000000000003818
Alan David Lam,Jessica H Leipman,Samantha S Meacock,Nihir Parikh,Matthew B Sherman,Yale A Fillingham,Chad A Krueger
BACKGROUNDAlthough deficits in social determinants of health (SDOH) have been previously associated with adverse clinical outcomes after primary THA and TKA, their role in the perioperative communication workload remains poorly characterized. Even though it remains essential to appropriately identify and address modifiable SDOH before a procedure, orthopaedic practices must also have the resources to handle the coordination of care effectively. Understanding how deficiencies in SDOH can impact communication workload would help support effective resource planning and equitable patient engagement strategies, particularly as more perioperative management takes place outside the hospital setting.QUESTIONS/PURPOSES(1) What are the differences in touchpoint utilization in patients who live in locations with varying Area Deprivation Index (ADI) scores, a surrogate measure for social deprivation? (2) Does social deprivation have an association with the length of stay (LOS) during primary total joint arthroplasty? (3) How are readmission rates and patient-reported outcome measures (PROMs) different in patients living in areas with varying degrees of social deprivation?METHODSIn this retrospective, comparative study, there were 92,801 patients who underwent primary, elective THA (43% [39,963]) or TKA (57% [52,837]) for osteoarthritis at one high-volume, urban, academic institution between January 2016 and December 2022. Of those, exclusions consisted of indications other than osteoarthritis (2% [1595]), no available ADI data (13% [12,302]), or loss to minimum 90-day postoperative follow-up and incomplete data (29% [26,836]). In all, 52,068 patients were included in the final analysis, with 43% (22,363) of patients undergoing primary THA and 57% (29,705) undergoing primary TKA. To determine the degree of social deprivation, the 2022 ADI was used and linked to patients' street addresses. Using the ADI national ranking from 1 to 100, with 1 representing the lowest level of disadvantage and 100 representing the highest level of disadvantage, patients were compared by ADI quartiles; Quartile 1 represented the least disadvantaged cohort and Quartile 4 represented the most disadvantaged cohort. Overall, the mean ± SD age was 66 ± 10 years, and the population consisted of 56% (29,333 of 52,068) women. Thirty-three percent (17,391 of 52,068) of patients were in ADI Quartile 1, 44% (22,944 of 52,068) were in Quartile 2, 17% (8650 of 52,068) were in Quartile 3, and 6% (3083 of 52,068) were in Quartile 4. The primary outcome measure was the number of touchpoints per patient, defined as the communication points (telephone or electronic messages) sent or received on behalf of the patient in relation to the total joint arthroplasty procedure. Touchpoints within the 30-day preoperative or 90-day postoperative periods of the primary THA or TKA were included. Secondary outcome measures included LOS, 90-day readmissions, and PROMs consisting of the Knee Injury and Osteoarthr
背景:尽管社会健康决定因素(SDOH)缺陷与原发性全髋关节置换术和全髋关节置换术后的不良临床结果有关,但其在围手术期沟通工作量中的作用仍不清楚。尽管在手术前适当识别和处理可修改的SDOH仍然是必要的,骨科实践也必须有资源来有效地处理护理协调。了解SDOH的缺陷如何影响沟通工作量,将有助于支持有效的资源规划和公平的患者参与策略,特别是在医院外进行更多围手术期管理的情况下。问题/目的(1)生活在不同地区的患者接触点利用的差异是什么?区域剥夺指数(ADI)是衡量社会剥夺的替代指标。(2)社会剥夺是否与初次全关节置换术的住院时间(LOS)有关?(3)生活在不同社会剥夺程度地区的患者再入院率和患者报告的预后指标(PROMs)有何不同?方法在这项回顾性比较研究中,2016年1月至2022年12月,在一个高容量的城市学术机构,有92,801例骨关节炎患者接受了原发性选择性THA(43%[39,963])或TKA(57%[52,837])。其中,排除包括骨关节炎以外的适应症(2%[1595]),无可用的ADI数据(13%[12,302]),或术后至少90天随访缺失和数据不完整(29%[26,836])。总共52,068例患者被纳入最终分析,其中43%(22,363)的患者接受了原发性THA, 57%(29,705)的患者接受了原发性TKA。为了确定社会剥夺的程度,使用了2022年的ADI,并将其与患者的街道地址联系起来。采用ADI国家排名从1到100,其中1代表最低的不利水平,100代表最高的不利水平,以ADI四分位数对患者进行比较;四分位数1代表最弱势群体,四分位数4代表最弱势群体。总体而言,平均±SD年龄为66±10岁,人口由56%(52,068人中29,333人)的女性组成。33%(52,068例中的17,391例)的患者属于ADI四分位数1,44%(52,068例中的22,944例)的患者属于四分位数2,17%(52,068例中的8650例)的患者属于四分位数3,6%(52,068例中的3083例)的患者属于四分位数4。主要结局指标是每位患者的接触点数量,定义为与全关节置换术相关的患者发送或接收的通信点(电话或电子信息)。包括原发性THA或TKA术前30天或术后90天的接触点。次要结局指标包括LOS、90天再入院率和PROMs,包括膝关节损伤和关节置换术骨关节炎结局评分(oos, JR)和髋关节残疾和关节置换术骨关节炎结局评分(HOOS, JR)。在接受THA和TKA的患者中,分别有34%(22,363例中有7627例)和35%(29,705例中有10,418例)获得HOOS、JR和kos、JR评分的变化。采用未调整和调整的二项回归模型来评估ADI四分位数与接触点数量的关系,通过接触点是传入还是输出来评估。结果在调整了年龄、性别、体重指数、种族和民族、手术年份等因素后,外向的、由员工发起的接触点比例随着社会剥夺程度的增加而增加。与四分位数1相比,ADI四分位数4的患者显示出最大的外向接触点增加(发病率比[IRR] 1.17[95%可信区间(CI) 1.11至1.25];P < 0.001)。对于每100个接触点发送给四分位数1的患者,大约有117个接触点发送给四分位数4的患者。然而,与四分位数1相比,四分位数4的接触点率最低(IRR 0.95 [95% CI 0.91至0.99];p = 0.01)。这意味着,每从处境最不利的四分位数患者那里获得100个接触点,就从处境最不利的四分位数患者那里获得大约95个接触点。四分位数4患者初次全关节置换术的平均±SD LOS为1.7±1.4天,而四分位数1患者的平均LOS为1.2±1.0天(p < 0.001)。随着剥夺程度的加重,当天出院和LOS < 24小时的比例逐步下降(p < 0.001)。与四分位数1的患者相比,四分位数4的患者当天出院率较低(7%[138 / 1894]对14% [1526 / 10623];p < 0.001)。四分位数4的患者90天再入院率较高,为4%(3083例中的111例),而四分位数1的患者再入院率最低,为3%(17391例中的460例)(p = 0.004)。 同样,再入院率随着剥夺程度的加重而逐渐增加。从完成术前和术后PROMs的患者中,在12个月时达到最小临床重要差异的患者比例在oos, JR (p = 0.32)和HOOS, JR (p = 0.67)的ADI四分位数中没有差异。结论:虽然ADI四分位数之间进出接触点的差异不大,但这些差异表明,实践可以使用一致的模式来告知基于公平的资源分配和有针对性的患者参与策略。骨科医生可以考虑社区水平的剥夺指数来预测沟通需求和围手术期支持。在护理障碍妨碍术后护理之前对来自更不利地区的患者进行定位至关重要。这可以通过灵活的术前教育、远程医疗、交通支持和预先确定的时间间隔的重点工作人员外展来实现。弱势地区的患者将受益于自助教育,以减轻传入的通信。未来的研究应该调查沟通工作量是否介导了剥夺指数和术后结果之间的关系,例如,对于来自弱势地区的患者来说,是否需要额外的工作人员发起的外诊,以达到与来自弱势社区的患者相当的PROM阈值。证据等级:III级,治疗性研究。
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引用次数: 0
What Substitution and Prediction Strategies Address the Challenge of an Unmeasurable C2-7 Cobb Angle? 什么替代和预测策略应对不可测量的C2-7 Cobb角的挑战?
IF 4.4 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-07 DOI: 10.1097/CORR.0000000000003812
Zerui Qin, Yu Ran, Zongshuo Sha, Lingmin Wu, Haodong Xiong, Qianzi Zhao, Zhongze Li, Jinsong Chen, Dongran Han, Yixing Liu, Jinyu Li, Jiang Chen
<p><strong>Background: </strong>The C2-7 Cobb angle is an important parameter in evaluating cervical sagittal alignment, which is widely used for preoperative planning, identifying surgical indications, and postoperative assessment. However, this angle becomes unmeasurable in 28% to 49% of clinical radiographs because of poor visualization of the C7 inferior endplate, limiting treatment planning and radiographic follow-up in cervical alignment assessment. The C2-6 Cobb angle has been proposed as a substitute in previous research, but these studies were limited by small symptomatic cohorts from a single center and lacked both subgroup-specific and external validation. Furthermore, there is currently a lack of reference standards for the clinical use of the C2-6 Cobb angle, and no established machine-learning models are available to accurately predict the C2-7 Cobb angle.</p><p><strong>Questions/purposes: </strong>(1) Can the C2-6 Cobb angle serve as a reliable substitute for the C2-7 angle? (2) Can machine-learning models accurately predict the C2-7 Cobb angle?</p><p><strong>Methods: </strong>We conducted a retrospective, multicountry imaging study from January 2020 to January 2025, utilizing standing lateral cervical spine radiographs from a large hospital data set in China and public data sets from Vietnam and India. In China, 11,800 radiographs were initially screened. The inclusion criterion was cervical radiographs of sufficient clarity. The exclusion criterion was cervical radiographs with incomplete visualization of anatomic structures. Following these exclusions, 10,571 radiographs from China were included, comprising 10,000 standard standing lateral radiographs plus 284 implant and 287 flexion-extension radiographs. From the public data sets, 470 radiographs from Vietnam and 62 from India were reviewed, with no radiographs excluded. A total of 11,103 radiographs were available for final analysis. Key variables included demographics (age, sex), symptomatic status, implant status, and radiographic sagittal parameters derived from standing lateral views. Four orthopaedic specialists labeled keypoints on the original radiographs, including the corner points of C2 to C7 and the centroid of C2. An algorithm was employed for precise measurement of the C2-6 and C2-7 Cobb angles. The Pearson correlation coefficient was calculated to assess the strength of the correlation between the C2-6 and C2-7 Cobb angles, and a linear regression analysis was applied to derive a predictive equation for the C2-7 Cobb angle based on the C2-6 Cobb angle. Subsequently, the 10,000 standard Chinese standing lateral radiographs were randomly assigned to the training set (80%) and the testing set (20%). An independent validation set (n = 1103) was established to assess robustness, comprising 284 implant radiographs and 287 flexion-extension radiographs from China, together with 470 from Vietnam and 62 from India.</p><p><strong>Results: </strong>Correlation analysis dem
背景:C2-7 Cobb角是评价颈椎矢状位对准的重要参数,广泛用于术前规划、手术指征识别及术后评估。然而,由于C7下终板的可视性差,该角度在28%至49%的临床x线片中无法测量,限制了治疗计划和颈椎对中评估的影像学随访。在以前的研究中,C2-6 Cobb角被提出作为替代,但这些研究受到来自单一中心的小症状队列的限制,缺乏亚组特异性和外部验证。此外,目前缺乏临床使用C2-6 Cobb角的参考标准,也没有成熟的机器学习模型可以准确预测C2-7 Cobb角。问题/目的:(1)C2-6 Cobb角可以作为C2-7角的可靠替代品吗?(2)机器学习模型能否准确预测C2-7 Cobb角?方法:我们从2020年1月至2025年1月进行了一项回顾性的多国影像学研究,利用来自中国大型医院数据集和越南和印度公共数据集的站立侧位颈椎x线片。在中国,最初筛查了11800张x光片。纳入标准是宫颈x线片足够清晰。排除标准为解剖结构显示不完全的颈椎x线片。在这些排除之后,纳入了来自中国的10,571张x线片,包括10,000张标准站立侧位x线片,284张植入x线片和287张屈伸x线片。从公共数据集中,审查了来自越南的470张x光片和来自印度的62张x光片,没有排除任何x光片。共有11,103张x光片可供最后分析。关键变量包括人口统计学(年龄、性别)、症状状态、种植体状态和从站立侧位角度得出的x线矢状面参数。四名骨科专家在原始x线片上标记关键点,包括C2至C7的角点和C2的质心。采用一种精确测量C2-6和C2-7 Cobb角的算法。计算Pearson相关系数评价C2-6与C2-7 Cobb角的相关性强弱,并基于C2-6 Cobb角进行线性回归分析,推导出C2-7 Cobb角的预测方程。随后,将10000张标准中国立式侧位x线片随机分配到训练集(80%)和测试集(20%)。建立了一个独立的验证集(n = 1103)来评估稳健性,包括来自中国的284张种植体x线片和287张屈伸x线片,以及来自越南的470张和来自印度的62张。结果:相关分析显示,总体人群中C2-6和C2-7 Cobb角呈正相关(r = 0.92; p < 0.001)。结合C2-6 Cobb角和其他矢状面参数的机器学习模型在估计C2-7 Cobb角方面取得了很高的预测精度,其中Lasso回归表现最好(R2 = 0.93,平均绝对误差[MAE] = 2.57)。此外,在验证集中观察到较强的性能(R2 = 0.95, MAE = 3.21)。在男性群体的亚群分析中,线性模型的验证效果最好,R2 = 0.94, MAE = 2.52。结论:C2-6和C2-7 Cobb角在不同国家、体位和植入物中均有很强的相关性和高度可解释的线性回归结果,表明C2-6 Cobb角可作为影像学中C2-7 Cobb角的可靠替代品。进一步分析发现,在人群水平上,C2-6 Cobb角比C2-7 Cobb角小约6°,可作为临床评价中标准化解释的重要参考。机器学习模型在估计C2-7 Cobb角方面取得了很高的预测精度,其中表现最好的模型(Lasso回归)的MAE为2.57,为临床应用提供了另一种选择。为了方便临床使用,我们提供了一个免费的在线工具(http://c2-7cobbanglepredictionsystem.online),该工具将至少维护15年。证据等级:III级,诊断性研究。
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