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Rhabdomyolysis Associated Acute Kidney Injury Following a Physical Violence 肢体暴力后横纹肌溶解相关急性肾损伤
Pub Date : 2021-10-30 DOI: 10.23937/2378-3656/1410367
Thivaharan Yalini, Kitulwatte Deepthi Gamage
Introduction: Physical violence can lead to serious and, rarely, fatal injuries. In addition to head injury, which is the leading cause of death and long-term disability, injuries of the musculoskeletal system and internal organs are important cause of assault-related morbidity. This paper discusses such rare complication of an interpersonal violence rhabdomyolyis associated with Acute Kidney Injury (AKI). Case: A 37-year-old man who claims to be assaulted by a group of people, presented with focal contusions and extensive grazed abrasions over the trunk and limbs. Injuries to brain and other visceral organs were excluded. Serum creatinine and urea were elevated significantly, along with increase in C-reactive protein and liver enzymes. Urinalysis contained red cells and leukocyte esterase, following which rhabdomyolysis was diagnosed. He developed oliguric AKI, and haemodialysis was initiated. He was discharged after eleven days of hospitalization, following improvement in renal functions. Discussion: Rhabdomyolysis is a common cause for oliguric renal failure, and can be traumatic or non-traumatic. Rhabdomyolysis has specific clinical and laboratory parameters, but still requires high level of suspicion, for timely diagnosis. Highly elevated levels creatinine phosphokinase (CPK) is the most specific parameter for the diagnosis of rhabdomyolysis. Myoglobinuria, elevated levels of lactase dehydrogenase and transaminases are also considered valuable markers of rhabdomyolysis. AKI is the commonest systemic complication of rhabdomyolysis and various causative mechanisms have been explained. Conclusion: Rhabdomyolysis requires high index of suspicion when acute kidney injury and altered metabolite levels are suspected in a patient with major or minor muscle injuries, in order to prevent complications or death.
导言:身体暴力可导致严重且极少致命的伤害。头部损伤是导致死亡和长期残疾的主要原因,除此之外,肌肉骨骼系统和内脏器官的损伤也是导致攻击相关疾病的重要原因。本文讨论这种罕见的并发症的人际暴力横纹肌溶解与急性肾损伤(AKI)。案例:一名37岁男子声称被一群人袭击,表现为局部挫伤,躯干和四肢有大面积擦伤。排除脑及其他内脏器官损伤。血清肌酐和尿素显著升高,c反应蛋白和肝酶升高。尿液分析含有红细胞和白细胞酯酶,随后诊断为横纹肌溶解。他发展为少尿性AKI,并开始血液透析。住院11天后,肾功能好转出院。讨论:横纹肌溶解是少尿性肾衰竭的常见原因,可为外伤性或非外伤性。横纹肌溶解有特定的临床和实验室参数,但仍需要高度怀疑,以便及时诊断。高水平的肌酐磷酸激酶(CPK)是诊断横纹肌溶解最具体的参数。肌红蛋白尿、乳糖脱氢酶和转氨酶水平升高也被认为是横纹肌溶解的有价值的标志。AKI是横纹肌溶解最常见的全身并发症,各种病因机制已得到解释。结论:当怀疑有严重或轻微肌肉损伤的患者存在急性肾损伤和代谢物水平改变时,横纹肌溶解需要高度的怀疑指数,以防止并发症或死亡。
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引用次数: 0
Laparoscopic Resection of a Gastric Lipoma: A Case Report 腹腔镜下胃脂肪瘤切除术1例报告
Pub Date : 2021-10-30 DOI: 10.23937/2378-3656/1410368
Najih Mohammed, Zentar Aziz
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引用次数: 0
Severe Malaria with Acute Kidney Injury and Post-Dialysis Hypocalcaemia and Hypertension: A Case Report of a Young Patient Managed in a Resource Limited Setting 严重疟疾伴急性肾损伤和透析后低钙血症和高血压:一例在资源有限的环境下管理的年轻患者报告
Pub Date : 2021-10-29 DOI: 10.23937/2378-3656/1410366
Innocent Wafula
Malaria is a leading cause of paediatric morbidity and mortality in Africa. Plasmodium falciparum species is commonly associated with severe complications of malaria including severe anaemia, prostration, altered consciousness, hypoglycaemia, pulmonary oedema, haemoglobinuria, and acute kidney injury (AKI). In patients with these complications, the cornerstone of treatment is prompt administration of antimalarials and the provision of appropriate supportive care. AKI is an established independent predictor for mortality in children with severe malaria. In patients with malaria-associated AKI, cautious fluid administration and renal replacement therapy could be lifesaving. In this case report, a 12-year-old patient was managed for severe malaria complicated by acute kidney injury (AKI) and post-dialysis hypocalcaemia and hypertension. malaria endemic zones. Among the parasites of the genus Plasmodium, (P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi), P. falciparum is the most common species associated with complications such as severe anaemia, prostration, altered consciousness, hypoglycaemia, pulmonary oedema, haemoglobinuria [3], and acute kidney injury [4]. We report a case of an older paediatric patient presenting with severe malaria with acute kidney injury (AKI) and post-dialysis hypocalcemia and hypertension.
疟疾是非洲儿童发病和死亡的主要原因。恶性疟原虫通常与疟疾的严重并发症有关,包括严重贫血、萎靡不振、意识改变、低血糖、肺水肿、血红蛋白尿和急性肾损伤(AKI)。对于出现这些并发症的患者,治疗的基础是及时给予抗疟药物和提供适当的支持性护理。急性肾损伤是严重疟疾患儿死亡率的独立预测指标。在与疟疾相关的AKI患者中,谨慎的输液和肾脏替代治疗可能挽救生命。在本病例报告中,一名12岁患者因严重疟疾并发急性肾损伤(AKI)和透析后低钙血症和高血压而接受治疗。疟疾流行区。在疟原虫属寄生虫(恶性疟原虫、间日疟原虫、疟疾疟原虫、卵形疟原虫和诺氏疟原虫)中,恶性疟原虫是最常见的一种,可导致严重贫血、虚脱、意识改变、低血糖、肺水肿、血红蛋白尿[3]和急性肾损伤[4]等并发症。我们报告一个老年儿科患者的情况下,严重疟疾急性肾损伤(AKI)和透析后低钙血症和高血压。
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引用次数: 0
Preventing Progression of Chronic Kidney Disease with Plant-Based Diet 植物性饮食预防慢性肾病的进展
Pub Date : 2021-10-29 DOI: 10.23937/2378-3656/1410365
Panigrahi Gunadhar
Chronic kidney disease (CKD) is associated with high incidence of morbidity, mortality, and is a costly burden to the healthcare system [1,2]. CKD is now the 8th leading cause of death in the United States and affects 14% of its people [3]. As CKD progresses, cardiovascular mortality rises, eventually becoming the most common cause of death among end-stage renal disease (ESRD) patients [4,5]. There is a growing interest in the dietary treatment of CKD, and a Plant-Based low-protein vegetarian diet has shown to be safe and effective in both treating and in slowing the progression of CKD [6]. These were treated with a stent to RCA and another stent to LAD with excellent angiographic results, with resolution of symptoms. At that time, her medications included Cozaar 50 mg po daily, Lopressor 50 mg po twice daily, Hydrochlorothiazide 25 mg po daily, Nitro-patch 2% topically daily, Zocor 40 mg po daily, Fenofibrate 134 mg po daily, Aspirin 81 mg po daily, Plavix 75 mg po daily, Neurontin 100 mg po daily. On 3/13/2014, after discharge from hospital, she was seen in our Cardiovascular Wellness Clinic for continued care. She weighed 207 pounds (BMI 30.55 kg/m2), blood pressure was 140/80 mm of Hg, and heart rate was 64 beats per minute. The lipid profile revealed a total cholesterol of 254 mg/dl, triglyceride 123 mg/dl, HDL cholesterol 51 mg/dl, and LDL cholesterol were 179 mg/dl. Evaluation of renal function revealed blood urea nitrogen of 31 mg/dl and creatinine was 1.4 mg/dl, and eGFR of 44 ml/min/1.73 m2 of body surface area.
慢性肾脏疾病(CKD)与高发病率、高死亡率相关,是医疗保健系统的昂贵负担[1,2]。CKD目前是美国第八大死因,影响了14%的美国人[3]。随着CKD的进展,心血管疾病死亡率上升,最终成为终末期肾病(ESRD)患者最常见的死亡原因[4,5]。人们对CKD的饮食治疗越来越感兴趣,以植物为基础的低蛋白素食饮食已被证明在治疗和减缓CKD进展方面是安全有效的[6]。这些患者接受了一个支架到RCA和另一个支架到LAD的治疗,血管造影结果良好,症状得到缓解。当时,她的药物包括Cozaar每日50毫克,Lopressor每日50毫克,每日2次,氢氯噻嗪每日25毫克,硝基贴剂每日2%局部涂抹,Zocor每日40毫克,非诺贝特每日134毫克,阿司匹林每日81毫克,Plavix每日75毫克,Neurontin每日100毫克。2014年3月13日,出院后,她来到我们的心血管健康诊所继续治疗。患者体重207磅(BMI 30.55 kg/m2),血压140/80 mm Hg,心率每分钟64次。脂质谱显示总胆固醇为254 mg/dl,甘油三酯为123 mg/dl, HDL胆固醇为51 mg/dl, LDL胆固醇为179 mg/dl。肾功能评估显示血尿素氮31 mg/dl,肌酐1.4 mg/dl, eGFR 44 ml/min/1.73 m2体表面积。
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引用次数: 1
Complete Perioral Reconstruction for High Power Electrical Burn 高功率电烧伤的全牙周重建
Pub Date : 2021-10-20 DOI: 10.23937/2378-3656/1410364
Abiel Kwok, Colin Hong
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引用次数: 0
Systemic Quinolones and Risk of Acute Liver Failure II: Systematic Review of Clinical Trials 系统性喹诺酮类药物和急性肝衰竭的风险II:临床试验的系统回顾
Pub Date : 2021-09-30 DOI: 10.23937/2378-3656/1410361
Taher Mohamed Kadry, Habsah Mohamed, Bjerre Lise, M. Franco, M. Donald, Krewski Daniel
Background: Quinolones are a class with four generations of synthetic antibiotics characterized by a unique mechanism of action, broad spectrum, potent pharmacologic properties and reasonable safety profile. Their global and growing popularity has been accompanied by an increase in the emergence of antimicrobial resistance and occurrence of unexpected adverse reactions. Nevertheless, physicians continue to prescribe these drugs on an increasing scale, irrespective of the availability of other treatment alternatives. Objective: To systematically review all clinical trials where a quinolone antibiotic was tested or used as a comparator to other drugs or drug combinations, for evidence on quinolones’ association with ALF risk. Methods: We examined 4 major bibliographic databases, 8 clinical trial registries, and major grey literature sources including international conference proceedings, drug review networks and databases of pharmaceutical companies for ongoing or unpublished studies. We also examined the bibliographies of publications selected for inclusion in our review for other relevant studies. PROSPERO registration number: CRD42020148742. Results: We identified 1,264 original clinical trials conducted between 1974 and 2020, in many countries around the world, enlisting men and women from almost all ethnicities, backgrounds, age groups and with different comorbidity burdens. One trial reported a single ALF case with gemifloxacin and the other reported another case with moxifloxacin. Conclusion: There is inadequate evidence from clinical trials to implicate quinolone antibiotics as a cause of acute liver failure.
背景:喹诺酮类药物是一类具有四代合成抗生素,具有作用机制独特、广谱、药理作用强、安全性合理等特点。它们在全球和日益普及的同时,抗菌素耐药性的出现和意外不良反应的发生也在增加。尽管如此,医生继续开这些药的规模越来越大,而不考虑其他治疗方案的可用性。目的:系统回顾所有喹诺酮类抗生素与其他药物或药物组合进行比较的临床试验,以寻找喹诺酮类抗生素与ALF风险相关的证据。方法:我们检索了4个主要的文献数据库、8个临床试验注册库和主要的灰色文献来源,包括国际会议论文集、药物审评网络和制药公司数据库,以获取正在进行或未发表的研究。我们还检查了入选我们综述的其他相关研究的出版物的参考书目。普洛斯彼罗注册号:CRD42020148742。结果:我们确定了1974年至2020年间在全球许多国家进行的1264项原始临床试验,招募了几乎所有种族、背景、年龄组和不同合并症负担的男性和女性。一项试验报告了一例使用吉氟沙星的ALF病例,另一项试验报告了另一例使用莫西沙星的ALF病例。结论:临床试验没有足够的证据表明喹诺酮类抗生素是急性肝衰竭的原因。
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引用次数: 1
Kallmann Syndrome with Brain Changes and Unilateral Renal Agenesis: A Rare Case Report Kallmann综合征伴脑改变及单侧肾脏发育不全:罕见病例报告
Pub Date : 2021-09-30 DOI: 10.33425/2768-6647.1006
M. Shirin, S. Al-Azad, S. Akter, Hasina Firdaus
Kallmann syndrome (KS) is a rare inherited disorder. It is characterized by hypogonadotropic hypogonadism in association with anosmia or hyposmia, results from defective migration of gonadotropin-releasing hormone producing neurons and olfactory axons. Because KS is a disease due to mutation of genes, patients with KS often display midline head and brain abnormalities such as cleft lip and/or palate and corpus callosum dysgenesis, septo-optic dysplasia, renal agenesis and other phenotypic abnormalities. Here we report a case of 19 years old boy presented with non-development of secondary sex characters, small penis, anosmia and clubfoot. Karyotype was 46XY and hormonal measurement revealed hypogonadotropic hypogonadism. MRI of the brain revealed bilateral agenesis of the olfactory bulb and sulcus, corpus callosal dysgenesis, septo-optic dysplasia and smaller pituitary gland. USG of abdomen revealed right renal agenesis.
卡尔曼综合征(KS)是一种罕见的遗传性疾病。它的特点是促性腺功能低下,伴有嗅觉缺失或低嗅觉,是由促性腺激素释放激素的神经元和嗅觉轴突迁移缺陷引起的。由于KS是一种由基因突变引起的疾病,因此KS患者常表现为头中线和脑部异常,如唇裂和/或腭裂、胼胝体发育不良、视中隔发育不良、肾发育不全等表型异常。我们在此报告一个十九岁的男孩,表现为第二性征不发育,阴茎小,嗅觉缺失和畸形足。核型46XY,激素测定显示促性腺功能减退。脑部MRI显示双侧嗅球及嗅沟发育不全,胼胝体发育不全,视隔发育不全,垂体较小。腹部超声示右肾发育不全。
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引用次数: 0
Bedside Techniques: Horseshoe Cartilage Ring-Preserving Tracheostomy for Preventing Stomal Site Stenosis 床边技术:马蹄软骨保环气管切开术预防造口部位狭窄
Pub Date : 2021-09-30 DOI: 10.33425/2768-6647.1007
K. Nakamoto, T. Fujii, Mika Kajiyama, Y. Kawamura
Introduction Post-tracheostomy cuff site stenosis (CSS) can be resolved using a soft cuff cannula [1], but there is no established treatment for stomal site stenosis (SSS), including subglottic stenosis (SGS), which can arise as a complication of tracheostomy [2,3]. To prevent SSS, we commonly use a tracheostomy procedure in which the framework of the horseshoe cartilage rings is preserved, as the trachea is opened transversely at the inter-cartilage ligament. This procedure is quite simple and involves a cannula being smoothly inserted using a percutaneous tracheostomy kit (PCT kit). As the number of tracheostomy procedures required has increased due to COVID19-related pneumonia, a standard tracheostomy procedure should be re-established.
气管造口术后袖带狭窄(CSS)可以通过软袖带插管来解决[1],但对于包括声门下狭窄(SGS)在内的气道造口部位狭窄(SSS)尚无成熟的治疗方法,这可能是气管造口术的并发症[2,3]。为了防止SSS,我们通常使用气管造口术,其中马蹄软骨环的框架被保留,因为气管在软骨间韧带处横向打开。这个过程非常简单,只需使用经皮气管造口术套件(PCT套件)顺利插入插管。由于covid - 19相关肺炎,需要的气管切开术数量增加,应重新建立标准的气管切开术程序。
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引用次数: 0
Premature Pubarche Secondary to Herbal Oil Exposure 暴露于草药油引起的早泄
Pub Date : 2021-09-30 DOI: 10.33425/2768-6647.1008
K. Jeyamurugan, Haiyan Lu
Premature pubarche (PP) is characterized by the growth of pubic hair before the age of 8 years in girls and 9 years in boys. In 80 to 95% of cases, PP is related to premature adrenarche (PA) secondary to idiopathic premature secretion of adrenal androgens. Although prepubertal pubarche is considered a variant of normal development, pathological causes should be ruled out, prompting a search for a source of androgen. Although hyperandrogenemia may be endogenous or exogenous in origin, most persons with prepubertal pubarche have normal serum concentrations of sex steroids, and an underlying cause is not identified. In such cases, possible exposure to endocrine disruptors should be considered. We report a case of premature pubarche in a 9-month-old boy who developed isolated pubarche after exposure to an herbal oil containing multiple essential oils including lavender, clary sage, grapefruit and peppermint. Pubarche resolved shortly after the use of herbal oil was discontinued.
阴毛过早(PP)的特点是在8岁之前的女孩和9岁之前的男孩的阴毛生长。在80% ~ 95%的病例中,PP与继发于特发性肾上腺雄激素分泌过早的早发性肾上腺增生(PA)有关。虽然青春期前阴毛被认为是正常发育的一种变体,但应排除病理原因,这促使人们寻找雄激素的来源。虽然高雄激素血症可能是内源性的,也可能是外源性的,但大多数青春期前阴毛症患者的血清性类固醇浓度正常,其根本原因尚不清楚。在这种情况下,应考虑可能接触内分泌干扰物。我们报告一例早产pubarche在一个9个月大的男孩谁开发孤立pubarche后暴露于含有多种精油的草药油,包括薰衣草,鼠尾草,葡萄柚和薄荷。在停止使用草药油后不久,Pubarche就消失了。
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引用次数: 0
The Gilets Jaunes, A Case of Collective Schizophrenia in France 黄马甲,法国集体精神分裂症的案例
Pub Date : 2021-09-30 DOI: 10.33425/2768-6647.1009
F. Pirot
This paper presents the application of the recently confirmed principles in which schizophrenia can first be diagnosed by actually looking at the discursive regime and observing contradictions i.e. taking schizophrenia to the word, a permanent process of self-breaking of the brain. The Gilets Jaunes self-destroyed their brains with the diesel fumes of the cars while agitating their demands against the government; this is the core of a movement that started with a mobilization order against high diesel taxes. Not only they campaigned both for lower taxes and for a stronger governmental welfare system, an obvious contradiction (first criteria) but they degenerated their brains progressively (second criteria). It is a dynamic, a process as in the pure etymology of schizophrein.
本文介绍了最近确认的原则的应用,其中精神分裂症可以首先通过实际观察话语制度和观察矛盾来诊断,即把精神分裂症带到这个词上,这是大脑自我破坏的一个永久过程。黄马甲人在鼓动反对政府的要求时,用汽车的柴油烟雾自我毁灭了他们的大脑;这是从反对高柴油税的动员令开始的运动的核心。他们不仅主张降低税收和加强政府福利体系,这是一个明显的矛盾(第一个标准),而且他们的大脑也在逐渐退化(第二个标准)。这是一个动态的过程,就像精神分裂症的纯粹词源一样。
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引用次数: 1
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