Pub Date : 2022-09-30DOI: 10.23937/2378-3656/1410404
C. K, A. S., O. E, H. Amal, Slimani F
Introduction: Merkel cell carcinoma of the upper eyelid is a rare and aggressive tumor. It develops from Merkel cells present in areas with glabrous skin. It touches females more than males. Presentation of case: A 42 years old female patient presented with a nodular painless and purplish lesion of the left upper eyelid. The diagnosis of Merkel cell carcinoma was made on histopathological examination and immunohistochemical analysis. Discussion: Large resection in free margins associated with radiotherapy allow control of the tumor at 6 months after treatment. Propeller flap, free tarsal graft and tarsoconjonctival flap are used for full recovery of form and function of the left upper eyelid. Conclusion: Aggressive surgical approach is mandatory to control extension of localized MCC of the eyelid which is a lymphophilic and potentially metastatic lesion.
{"title":"Merkel Cell Carcinoma of the Upper Eyelid: A Case Report and Review of the Literature","authors":"C. K, A. S., O. E, H. Amal, Slimani F","doi":"10.23937/2378-3656/1410404","DOIUrl":"https://doi.org/10.23937/2378-3656/1410404","url":null,"abstract":"Introduction: Merkel cell carcinoma of the upper eyelid is a rare and aggressive tumor. It develops from Merkel cells present in areas with glabrous skin. It touches females more than males. Presentation of case: A 42 years old female patient presented with a nodular painless and purplish lesion of the left upper eyelid. The diagnosis of Merkel cell carcinoma was made on histopathological examination and immunohistochemical analysis. Discussion: Large resection in free margins associated with radiotherapy allow control of the tumor at 6 months after treatment. Propeller flap, free tarsal graft and tarsoconjonctival flap are used for full recovery of form and function of the left upper eyelid. Conclusion: Aggressive surgical approach is mandatory to control extension of localized MCC of the eyelid which is a lymphophilic and potentially metastatic lesion.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74777840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.23937/2378-3656/1410406
Kandemir Ersin, Gökdemir Begüm, Kaya Deniz, Leblebici Figen, Çekmen Nedim
Epidermolysis bullosa (EB) is a mucocutaneous disorder characterized by fragility of skin and mucosal membranes to the mechanical stress resulting formation of blisters, erosions and scarring. Their vulnerability needs certain attention and anesthetic management plan to perform anesthesia requiring procedures and surgeries without complications. In our case, a patient with EB had undergone an esophageal dilatation procedure. We present an anesthetic management strategy for these patients.
{"title":"Anesthetic Management of a Patient with Epidermolysis Bullosa for Esophageal Dilatation: A Case Report","authors":"Kandemir Ersin, Gökdemir Begüm, Kaya Deniz, Leblebici Figen, Çekmen Nedim","doi":"10.23937/2378-3656/1410406","DOIUrl":"https://doi.org/10.23937/2378-3656/1410406","url":null,"abstract":"Epidermolysis bullosa (EB) is a mucocutaneous disorder characterized by fragility of skin and mucosal membranes to the mechanical stress resulting formation of blisters, erosions and scarring. Their vulnerability needs certain attention and anesthetic management plan to perform anesthesia requiring procedures and surgeries without complications. In our case, a patient with EB had undergone an esophageal dilatation procedure. We present an anesthetic management strategy for these patients.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75806778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.23937/2378-3656/1410405
Erdir Batuhan, Fikri Burcu Ileri, Demirhisar Irem Ezgi, Turan Guldem
Tuberculous meningitis (TBM) is the most fatal form of the Mycobacterium tuberculosis infection. Its diagnosis remains difficult due to poor suspicion of the disease especially in the case of pregnancy. We bring to your attention a 27-year-old pregnant woman who came to the emergency department with headache and nausea. With high clinical suspicion and early treatment with Meropenem 3x2 gram, Levofloxacin 2 x 500 mg, Amoxicillin Clavulanate 3 x 1 gram, Ethambutol 1 x 25 mg/kg body weight, Pyrazinamide 1 x 15 mg/kg body weight and 0.4 mg/kg body weight Dexamethasone resulted in patient’s recovery. The immune tolerant state of pregnancy and its relationship with the M. tuberculosis infections needs further research. Clinicians need to think about the TBM and other tuberculosis infections for prompt diagnosis and early treatment.
{"title":"Multi-Drug Resistant Tuberculous Meningitis in a Pregnant Woman","authors":"Erdir Batuhan, Fikri Burcu Ileri, Demirhisar Irem Ezgi, Turan Guldem","doi":"10.23937/2378-3656/1410405","DOIUrl":"https://doi.org/10.23937/2378-3656/1410405","url":null,"abstract":"Tuberculous meningitis (TBM) is the most fatal form of the Mycobacterium tuberculosis infection. Its diagnosis remains difficult due to poor suspicion of the disease especially in the case of pregnancy. We bring to your attention a 27-year-old pregnant woman who came to the emergency department with headache and nausea. With high clinical suspicion and early treatment with Meropenem 3x2 gram, Levofloxacin 2 x 500 mg, Amoxicillin Clavulanate 3 x 1 gram, Ethambutol 1 x 25 mg/kg body weight, Pyrazinamide 1 x 15 mg/kg body weight and 0.4 mg/kg body weight Dexamethasone resulted in patient’s recovery. The immune tolerant state of pregnancy and its relationship with the M. tuberculosis infections needs further research. Clinicians need to think about the TBM and other tuberculosis infections for prompt diagnosis and early treatment.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74368976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mgazzen F, H. M, Baccouche S, Osmane R, S. A, G. L., Mestiri H, B. S, Bacha D
{"title":"Small Intestine Metastasis From Colic Adenocarcinoma","authors":"Mgazzen F, H. M, Baccouche S, Osmane R, S. A, G. L., Mestiri H, B. S, Bacha D","doi":"10.33425/2768-6647.1023","DOIUrl":"https://doi.org/10.33425/2768-6647.1023","url":null,"abstract":"","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86928939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zuccarino, V. Prada, Genovese, A. Gray, A. Schenone, D. Pareyson, M. Shy
CMT and other neuromuscular diseases are at an increased risk for severe presentations of COVID-19. We investigated how many participants in our online cohort were diagnosed with COVID-19, the symptoms they presented with, the presence of risk factors, and how the COVID-19 impacted the progression of their CMT. Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a pandemic and public health emergency caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Our study evaluated the impact of the COVID-19 on patients with Charcot-Marie-Tooth (CMT), the most common genetic neuromuscular disorder. Methods: A simple online questionnaire for CMT patients diagnosed with COVID-19 was developed to investigate how much the COVID-19 impacted the community of CMT patients and its consequences on the progression of CMT. With the support of the Italian CMT patient Association (ACMT-Rete) and the American CMT Association (CMTA), the survey was distributed electronically through the INC Contact Registry and the web-based Contact Registry in the US, and in Italy through the Italian CMT Registry, ACMT-Rete members newsletter and social networks. Results: 152 individuals completed the survey. Approximately 59% of completers were female, and the average age was 49.96 (SD 12,65, range 22-76 years). 13.8% of the respondents had a COVID diagnosis and 2% (n=3) of them were health workers. Symptoms of COVID-19 were typically mild and none went to the ICU. Discussion: These results do not show a clear increased risk of COVID in people with CMT.
{"title":"CMT-COVID Survey","authors":"Zuccarino, V. Prada, Genovese, A. Gray, A. Schenone, D. Pareyson, M. Shy","doi":"10.31038/cmcrr.2022211","DOIUrl":"https://doi.org/10.31038/cmcrr.2022211","url":null,"abstract":"CMT and other neuromuscular diseases are at an increased risk for severe presentations of COVID-19. We investigated how many participants in our online cohort were diagnosed with COVID-19, the symptoms they presented with, the presence of risk factors, and how the COVID-19 impacted the progression of their CMT. Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a pandemic and public health emergency caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Our study evaluated the impact of the COVID-19 on patients with Charcot-Marie-Tooth (CMT), the most common genetic neuromuscular disorder. Methods: A simple online questionnaire for CMT patients diagnosed with COVID-19 was developed to investigate how much the COVID-19 impacted the community of CMT patients and its consequences on the progression of CMT. With the support of the Italian CMT patient Association (ACMT-Rete) and the American CMT Association (CMTA), the survey was distributed electronically through the INC Contact Registry and the web-based Contact Registry in the US, and in Italy through the Italian CMT Registry, ACMT-Rete members newsletter and social networks. Results: 152 individuals completed the survey. Approximately 59% of completers were female, and the average age was 49.96 (SD 12,65, range 22-76 years). 13.8% of the respondents had a COVID diagnosis and 2% (n=3) of them were health workers. Symptoms of COVID-19 were typically mild and none went to the ICU. Discussion: These results do not show a clear increased risk of COVID in people with CMT.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85151445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sternocostoclavicular hyperostosis (SCCH) is a chronic osssifying diathesis affecting mostly juxtasternal structures and the inflammatory osteitis is mostly part of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. we presented a case of 62-year-old woman with polyarthritis in bilateral hands, who had experienced swelling of anterior chest wall sinse she was 30 years old. we decided to treat her with an anti-TNF α antibody biologics, golimumab, after failure of conventional disease-modifying antirheumatic drugs (Cs DMARDs). Although clinical remisson had been successfuly induced, rapid progression of SCCH and skin menifestation were confirmed without recurrence of the peripheral arthritis. Results of the bone biopsy and the culture study indicated the relapse of SCCH was not caused by infection or neoplasma and, postoperatively, the chest pain was gradually decreased and along with an improvement of the skin erruption.
{"title":"Rapid Progression of Sternocostoclavicular Hyperostosis (SCCH) Observed after Anti-TNF-a Therapy for Polyarthritis: A Case Report","authors":"Kitagawa Atsushi, Takahashi Mitsuhiko, Nakamura Tomoko, Hashimoto Yasushi","doi":"10.23937/2378-3656/1410402","DOIUrl":"https://doi.org/10.23937/2378-3656/1410402","url":null,"abstract":"Sternocostoclavicular hyperostosis (SCCH) is a chronic osssifying diathesis affecting mostly juxtasternal structures and the inflammatory osteitis is mostly part of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. we presented a case of 62-year-old woman with polyarthritis in bilateral hands, who had experienced swelling of anterior chest wall sinse she was 30 years old. we decided to treat her with an anti-TNF α antibody biologics, golimumab, after failure of conventional disease-modifying antirheumatic drugs (Cs DMARDs). Although clinical remisson had been successfuly induced, rapid progression of SCCH and skin menifestation were confirmed without recurrence of the peripheral arthritis. Results of the bone biopsy and the culture study indicated the relapse of SCCH was not caused by infection or neoplasma and, postoperatively, the chest pain was gradually decreased and along with an improvement of the skin erruption.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87002141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Crohn’s disease is a rare disease with a chronic relapsing course. Usually begins at a young age influenced by environmental, genetic, and immunological factors. Patients mostly have only intestinal changes. In addition to the gut, other organs, such as skin, joints, liver, and kidneys can be affected. The type of treatment and choice of drugs depends on the type and severity of the disease. Objective: Managing a patient with Crohn’s disease requires an individual and holistic approach to treatment by a family physician complemented with good cooperation with gastroenterologists and other clinical specialists. In the process of long-term care family physician provides psychosocial support to the patient in overcoming the disease. Discussion: Here we describe the details of a case with a review of the literature. Based on history taking, physical examination, and investigation, the patient was diagnosed with Crohn’s disease.
{"title":"Perspectives in the Treatment of Crohn's Disease by a Physician of Family Medicine: A Clinical Case Presentation","authors":"Vučkič Luka, Zadravec Eva, Rakuša Igor, Rakuša Mateja","doi":"10.23937/2378-3656/1410401","DOIUrl":"https://doi.org/10.23937/2378-3656/1410401","url":null,"abstract":"Background: Crohn’s disease is a rare disease with a chronic relapsing course. Usually begins at a young age influenced by environmental, genetic, and immunological factors. Patients mostly have only intestinal changes. In addition to the gut, other organs, such as skin, joints, liver, and kidneys can be affected. The type of treatment and choice of drugs depends on the type and severity of the disease. Objective: Managing a patient with Crohn’s disease requires an individual and holistic approach to treatment by a family physician complemented with good cooperation with gastroenterologists and other clinical specialists. In the process of long-term care family physician provides psychosocial support to the patient in overcoming the disease. Discussion: Here we describe the details of a case with a review of the literature. Based on history taking, physical examination, and investigation, the patient was diagnosed with Crohn’s disease.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87687646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Colorectal cancer is very rare in children. Therefore, the diagnosis is generally established at advanced disease. This is a presentation of two cases of colorectal treated at Habib Bourguiba Hospital University. Case presentation Two adolescents, 14-year-old and 16-year-old were treated for CRC between 2006 and 2022 in our department. Both complained about abdominal and pelvic pain few months ago. The first patient, with no personal or family history of digestive pathology, was admitted for peritonitis. The exploration noted advanced rectal tumor, peritoneal carcinomatosis and bone metastasis. She had one cycle of palliative FOLFIRI chemotherapy and died. The other one was admitted for complicated appendicitis. Per operative exploration noted localized sigmoid tumor which was resected. She had 12 cycles of adjuvant FOLFOX chemotherapy and she was alive and free failure for 13 years. Her paternal uncle had yet rectal cancer at 40 years and her father developed later metastatic colon cancer. Lynch syndrome was established.
{"title":"Colorectal Cancer in Adolescence: A Report of Two Cases","authors":"Masmoudi Ines AYADI, Souissi Basma, Kallel Rim, Ameur Hazem BEN, K. Afef","doi":"10.23937/2378-3656/1410398","DOIUrl":"https://doi.org/10.23937/2378-3656/1410398","url":null,"abstract":"Background Colorectal cancer is very rare in children. Therefore, the diagnosis is generally established at advanced disease. This is a presentation of two cases of colorectal treated at Habib Bourguiba Hospital University. Case presentation Two adolescents, 14-year-old and 16-year-old were treated for CRC between 2006 and 2022 in our department. Both complained about abdominal and pelvic pain few months ago. The first patient, with no personal or family history of digestive pathology, was admitted for peritonitis. The exploration noted advanced rectal tumor, peritoneal carcinomatosis and bone metastasis. She had one cycle of palliative FOLFIRI chemotherapy and died. The other one was admitted for complicated appendicitis. Per operative exploration noted localized sigmoid tumor which was resected. She had 12 cycles of adjuvant FOLFOX chemotherapy and she was alive and free failure for 13 years. Her paternal uncle had yet rectal cancer at 40 years and her father developed later metastatic colon cancer. Lynch syndrome was established.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76355873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-31DOI: 10.23937/2378-3656/1410399
Cham B E
cells and normal skin cells. Furthermore, Curaderm is highly specific and is capable of causing cancer cell death by the orderly process of apoptosis. The clinical aspects of Curaderm pharmacotherapy have amply been described in the literature. Recently, a thought-provoking article “Curaderm, the long-awaited breakthrough for basal cell carcinoma” was published. Although the article is awe-inspiring, it does not address the mechanisms and mode of actions of Curaderm that achieve such remarkable clinical outcomes. This communication centres on the pharmacological mechanisms, which establish that Curaderm is indeed both selective and specific in eliminating basal cell carcinoma from the skin.
{"title":"The Pharmacology of Curaderm in the Treatment of Basal Cell Carcinoma","authors":"Cham B E","doi":"10.23937/2378-3656/1410399","DOIUrl":"https://doi.org/10.23937/2378-3656/1410399","url":null,"abstract":"cells and normal skin cells. Furthermore, Curaderm is highly specific and is capable of causing cancer cell death by the orderly process of apoptosis. The clinical aspects of Curaderm pharmacotherapy have amply been described in the literature. Recently, a thought-provoking article “Curaderm, the long-awaited breakthrough for basal cell carcinoma” was published. Although the article is awe-inspiring, it does not address the mechanisms and mode of actions of Curaderm that achieve such remarkable clinical outcomes. This communication centres on the pharmacological mechanisms, which establish that Curaderm is indeed both selective and specific in eliminating basal cell carcinoma from the skin.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77774729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-31DOI: 10.23937/2378-3656/1410400
Wei-hua Li, Zou Zehui, Xuqiang Liu, Xiaofeng Li
Background: Long-term hemodialysis treatment of chronic kidney disease (CKD) can lead to disorder of calcium and phosphorus regulation and abnormal parathyroid function. Most patients with renal failure often have secondary hyperparathyroidism, at which time the parathyroid glands can release large amounts of parathyroid hormone (PTH), which activate osteoclast activity to increase serum calcium levels, resulting in severe skeletal diseases, including osteoporosis, pathological fractures, bone pain. Case presentation: We report a case of a 62-year-old woman with bilateral femoral neck pathological fractures who was diagnosed with tertiary hyperparathyroidism and severe osteoporosis due to long-term hemodialysis treatment for renal failure. On the 1st day after bilateral total hip arthroplasty (THA), sudden seizure resulted in periprosthetic fractures and acetabular loosening. After the patient’s condition stabilized, bilateral revision total hip arthroplasty was performed respectively. There are no similar reports in the previous literature. Conclusions: Perioperative anti-osteoporotic therapy and close monitoring of serum calcium levels are beneficial in long-term hemodialysis patients with hip fractures. At the same time, more attention should be paid to refractures caused by severe osteoporosis and hypocalcemic seizure after THA.
{"title":"Periprosthetic Fractures and Acetabular Loosening after Surgical Treatment of Bilateral Femoral Neck Pathological Fractures Secondary to Hypocalcemic Seizure with Chronic Renal Failure：A Case Report and Review of the Literature","authors":"Wei-hua Li, Zou Zehui, Xuqiang Liu, Xiaofeng Li","doi":"10.23937/2378-3656/1410400","DOIUrl":"https://doi.org/10.23937/2378-3656/1410400","url":null,"abstract":"Background: Long-term hemodialysis treatment of chronic kidney disease (CKD) can lead to disorder of calcium and phosphorus regulation and abnormal parathyroid function. Most patients with renal failure often have secondary hyperparathyroidism, at which time the parathyroid glands can release large amounts of parathyroid hormone (PTH), which activate osteoclast activity to increase serum calcium levels, resulting in severe skeletal diseases, including osteoporosis, pathological fractures, bone pain. Case presentation: We report a case of a 62-year-old woman with bilateral femoral neck pathological fractures who was diagnosed with tertiary hyperparathyroidism and severe osteoporosis due to long-term hemodialysis treatment for renal failure. On the 1st day after bilateral total hip arthroplasty (THA), sudden seizure resulted in periprosthetic fractures and acetabular loosening. After the patient’s condition stabilized, bilateral revision total hip arthroplasty was performed respectively. There are no similar reports in the previous literature. Conclusions: Perioperative anti-osteoporotic therapy and close monitoring of serum calcium levels are beneficial in long-term hemodialysis patients with hip fractures. At the same time, more attention should be paid to refractures caused by severe osteoporosis and hypocalcemic seizure after THA.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89591663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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