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Leveraging three-dimensional craniofacial morphology for customized abutment design using facial scanning technology. 利用三维颅面形态,利用面部扫描技术定制基台设计。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-11 DOI: 10.1007/s00784-025-06701-x
Kaijin Lin, Yongqing Guo, Shuang Wu, Wencan Ning, Jin Yang, Dong Wu, Jianbin Guo

Objectives: This study aimed to investigate the correlation between the dental cervical morphology (DCM) of maxillary anterior teeth and facial parameters, with the goal of validating the predictive efficacy of these facial parameters for DCM of the maxillary anterior teeth in a Chinese population.

Materials and methods: This cross-sectional study was conducted at Stomatology Hospital of Fujian Medical University. Facial parameters of participants were obtained using a 3D facial scanner and subsequently imported into reverse engineering software for measurement. Cone beam computed tomography (CBCT) data were imported into imaging software, where specific landmarks were annotated. The distance between these landmarks at the cemento-enamel junction (CEJ) level was then quantified and defined as dental cervical morphology (DCM). Pearson correlation analysis was employed to identify relationships between facial and DCM measurements. Linear regression was performed on significantly correlated variables, while t-tests evaluated the difference of real value and predicted value (α = 0.05).

Results: A total of 147 volunteers participated in this study. Significant correlations for DCM were observed with interlateral canthus width (LCW) in males (P < 0.05) and with intermedial canthus width (MCW) in females (P < 0.05). Regression equations based on facial parameters showed no significant differences between predicted and actual values for DCM (P > 0.05), with LCW used for males and MCW for females (P > 0.05).

Conclusions: DCM of the maxillary anterior teeth was found to be associated with facial width, with LCW serving as a potential predictor for males and MCW for females. These findings suggested that facial morphology could be a valuable predictor for DCM.

Clinical relevance: Facial parameters offer a reliable basis for the precise design of customized abutments, enhancing the accuracy and efficiency of clinical prosthodontic treatments, particularly in implantology and aesthetic restoration.

Trial registration: This study was approved by the Biomedical Research Ethics Committee of Stomatology Hospital of Fujian Medical University (approval no. 2023-24).

目的:本研究旨在探讨上颌前牙牙颈形态(DCM)与面部参数的相关性,验证面部参数对中国人群上颌前牙DCM的预测效果。材料与方法:横断面研究在福建医科大学口腔医院进行。使用三维面部扫描仪获取参与者的面部参数,然后导入逆向工程软件进行测量。锥束计算机断层扫描(CBCT)数据被导入成像软件,其中特定的地标被注释。这些标记在牙骨质-牙釉质交界处(CEJ)水平之间的距离被量化并定义为牙颈形态(DCM)。采用Pearson相关分析来确定面部和DCM测量之间的关系。对显著相关变量进行线性回归,t检验评价真实值与预测值的差异(α = 0.05)。结果:共有147名志愿者参与了本研究。DCM与男性侧眦宽度(LCW)显著相关(P < 0.05),其中男性为LCW,女性为MCW (P < 0.05)。结论:上颌前牙DCM与面部宽度相关,男性LCW和女性MCW可作为潜在的预测因子。这些发现表明,面部形态可能是DCM的一个有价值的预测指标。临床意义:面部参数为精确设计定制基牙提供了可靠的依据,提高了临床修复治疗的准确性和效率,特别是在种植和美学修复方面。试验注册:本研究已获福建医科大学口腔医院生物医学研究伦理委员会批准(批准号:2023 - 24)。
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引用次数: 0
Association between oral diseases and oral Helicobacter pylori infection: A systematic review and meta-analysis. 口腔疾病与口腔幽门螺杆菌感染的关系:一项系统综述和荟萃分析。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-11 DOI: 10.1007/s00784-025-06691-w
Meng Wang, Pei-Hui Ding, Yun Qian, Li-Jie Fan

Objectives: Helicobacter pylori (H. pylori) is a prevalent gastric bacterium increasingly detected in the oral cavity and may contribute to the progression of oral diseases. This study aimed to assess the association between oral diseases and oral H. pylori infection.

Materials and methods: A systematic review and meta-analysis of observational studies was conducted to compare oral H. pylori prevalence between patients with oral diseases and healthy controls. Data were pooled to estimate overall associations, and subgroup analyses were performed by oral disease type, detection site, detection methods, and region to assess their potential impact on the observed relationships.

Results: Ten studies with 1166 participants met the inclusion criteria. Oral H. pylori infection was significantly associated with oral diseases (OR = 3.24, 95%CI:1.78-5.92, p = 0.0001), particularly periodontitis (OR = 4.28, 95%CI:2.46-7.44). The strongest associations were observed when H. pylori was detected in dental plaque (OR = 4.65, 95% CI: 2.60-8.33), using polymerase chain reaction (PCR)-based methods (OR = 4.09, 95% CI: 2.31-7.24), and in Asian populations. Sensitivity analyses confirmed the robustness of these results, and no publication bias was detected.

Conclusions: Oral H. pylori, particularly when detected in dental plaque by PCR, is strongly associated with periodontitis, suggesting that it may contribute to the progression of oral diseases. However, these findings are limited by potential confounding and the observational nature of the included studies, warranting cautious interpretation and further prospective research.

Clinical relevance: Oral H. pylori is associated with periodontitis, highlighting the need for standardized detection methods and further prospective studies to clarify causal mechanisms and guide integrated management of oral diseases and the risk of gastric reinfection.

目的:幽门螺杆菌(Helicobacter pylori, H. pylori)是一种在口腔中越来越常见的胃细菌,可能与口腔疾病的进展有关。本研究旨在评估口腔疾病与口腔幽门螺杆菌感染之间的关系。材料和方法:对观察性研究进行系统回顾和荟萃分析,比较口腔疾病患者和健康对照者的口腔幽门螺杆菌患病率。汇总数据以估计总体相关性,并按口腔疾病类型、检测部位、检测方法和地区进行亚组分析,以评估其对观察到的关系的潜在影响。结果:10项研究1166名受试者符合纳入标准。口腔幽门螺旋杆菌感染与口腔疾病有显著相关性(OR = 3.24, 95%CI:1.78 ~ 5.92, p = 0.0001),尤其是牙周炎(OR = 4.28, 95%CI:2.46 ~ 7.44)。当在牙菌斑中检测到幽门螺杆菌时(OR = 4.65, 95% CI: 2.60-8.33),使用基于聚合酶链反应(PCR)的方法(OR = 4.09, 95% CI: 2.31-7.24),以及在亚洲人群中观察到最强的相关性。敏感性分析证实了这些结果的稳健性,没有发现发表偏倚。结论:口腔幽门螺杆菌,特别是在牙菌斑中通过PCR检测到的幽门螺杆菌与牙周炎密切相关,表明它可能有助于口腔疾病的进展。然而,这些发现受到潜在的混淆和纳入研究的观察性质的限制,需要谨慎解释和进一步的前瞻性研究。临床意义:口腔幽门螺杆菌与牙周炎相关,需要标准化的检测方法和进一步的前瞻性研究来阐明因果机制,指导口腔疾病和胃再感染风险的综合管理。
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引用次数: 0
Salivary metabolite-based prediction of radiotherapy-induced oral mucositis and candidiasis. 基于唾液代谢物的放射治疗引起的口腔黏膜炎和念珠菌病预测。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-11 DOI: 10.1007/s00784-025-06690-x
Saga Ramsay, Eelis Hyvärinen, Jopi Mikkonen, Wilfredo Alejandro González-Arriagada, Tuula Salo, Márcio Ajudarte Lopes, Bina Kashyap, Arja M Kullaa

Objectives: Oral toxicities affect a high proportion of head and neck cancer (HNC) patients receiving radiotherapy, lacking reliable predictive biomarkers for incidence and severity. We investigated salivary metabolites and metabolic pathways as non-invasive predictors of radiotherapy-induced oral mucositis (OM) and candidiasis.

Material and methods: HNC patients undergoing radiotherapy were prospectively studied. Saliva samples of 45 HNC patients and 30 controls were analysed using NMR spectroscopy, and patients were assessed for oral complications during treatment.

Results: Significant metabolite differences were identified between patients with and without complications. An increased concentration of lactate (p < 0.000), and a reduced concentration of formate (p = 0.018) and pyruvate (p = 0.045), was found in HNC patients at risk for OM during RT. Comparison of salivary metabolites between patients at risk or not risk for candidiasis presented increases in acetate (p = 0.005), alanine (p = 0.009), proline (p = 0.002), tyrosine (p < 0.000), trimethylamine (p = 0.007) and fucose (p < 0.000), whereas the level of citrate (p = 0.008) was decreased. Of the metabolic pathways, glucose-alanine cycle and thyroid hormone synthesis, were significantly different in patients at risk for candidiasis.

Conclusions: Salivary metabolomics is a promising predictive tool for radiotherapy-induced oral complications, potentially enabling early intervention and personalized supportive care.

Clinical relevance: Elevated level of salivary lactate seems to predict the development of OM, while fucosis was a sign of candidiasis. Multicentre validation studies are needed for its clinical implementation.

目的:口服毒性影响高比例接受放疗的头颈癌(HNC)患者,缺乏可靠的预测发病率和严重程度的生物标志物。我们研究了唾液代谢物和代谢途径作为放疗引起的口腔黏膜炎(OM)和念珠菌病的非侵入性预测因子。材料与方法:前瞻性研究接受放疗的HNC患者。采用核磁共振波谱法分析45例HNC患者和30例对照者的唾液样本,并评估患者在治疗期间的口腔并发症。结果:在有和无并发症的患者之间发现了显著的代谢物差异。结论:唾液代谢组学是一种很有前景的预测放疗引起的口腔并发症的工具,有可能实现早期干预和个性化支持护理。临床相关性:唾液乳酸水平升高似乎预测OM的发展,而焦点是念珠菌病的征兆。临床应用需要多中心验证研究。
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引用次数: 0
Oral cancer in women: clinical profile, risk factors, treatment outcomes and survival predictors in 32 years of experience. 女性口腔癌:32年经验中的临床概况、危险因素、治疗结果和生存预测因素
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-10 DOI: 10.1007/s00784-025-06692-9
Diovana de Melo Cardoso, Regiane Mazzarioli Pereira Nogueira, Gabrielle Dias Duarte, Anne Cristina de Faria Cocato, Daniene Tesoni Cassavara Ribeiro, Patricia Gonçalves Barbosa, Sebastião Conrado-Neto, Francisco Urbano Collado, Everton Pontes Martins, Aline Satie Takamiya, Vitor Bonetti Valente, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Daniel Galera Bernabé

Objective: An increase in the incidence of oral cancer in women has been reported in some countries. This study investigated demographic, clinicopathological, risk factors, treatment outcomes and predictors for survival in female patients with oral cancer treated in a reference head and neck cancer center for the past 32 years.

Methods: This retrospective cohort study reviewed the clinical records of women patients with oral squamous cell carcinoma (OSCC). The proportion of OSCC cases in women relative to men over the last three decades was investigated. Clinicopathological data were correlated with treatment outcomes using logistic regression analysis. The 2 and 5-year overall survival (OS) and disease-specific survival (DSS) were assessed through the Kaplan-Meier and Cox regression analyses.

Results: In total, 133 women patients with OSCC were investigated. The ratio of oral cancer cases in women to men has almost doubled in the last decade. Most female patients were non-smokers (51.9%) and non-alcoholics (69.2%) and had early-stage disease at the time of diagnosis (51.9%). The most frequent tumor sites were tongue (46.6%) and alveolar ridge (18%). Advanced clinical stage was the independent predictor for worse 5-year OS (p < 0.001) and DSS (p < 0.001), while non-surgical treatment was associated with poor OS only at the 2-year cutoff (p = 0.003).

Conclusion: This study demonstrates an increase in the proportion of oral cancer cases in women in the last decade. Advanced-stage tumors remain the main predictor for women with oral cancer, denoting the need to strengthen policies to increase the rate of early diagnosis for this population.

Clinical relevance: The number of female patients with oral cancer without the classic risk factors for the disease has been increasing over the years. Clinicians should be alerted to ulcerated lesions in the oral mucosa of non-smoking and non-alcoholic women, favoring early diagnosis.

目的:据报道,一些国家的女性口腔癌发病率有所上升。本研究调查了过去32年在参考头颈癌中心治疗的女性口腔癌患者的人口学、临床病理、危险因素、治疗结果和生存预测因素。方法:回顾性队列研究回顾了女性口腔鳞状细胞癌(OSCC)患者的临床记录。调查了过去三十年中女性OSCC病例相对于男性的比例。采用logistic回归分析将临床病理资料与治疗结果相关联。通过Kaplan-Meier和Cox回归分析评估2年和5年总生存期(OS)和疾病特异性生存期(DSS)。结果:共调查133例女性OSCC患者。在过去十年中,女性口腔癌病例与男性口腔癌病例的比例几乎翻了一番。大多数女性患者不吸烟(51.9%)和不酗酒(69.2%),诊断时疾病处于早期(51.9%)。最常见的肿瘤部位为舌部(46.6%)和牙槽嵴(18%)。结论:该研究表明,在过去十年中,女性口腔癌病例的比例有所增加。晚期肿瘤仍然是女性口腔癌的主要预测指标,这表明需要加强政策以提高这一人群的早期诊断率。临床相关性:近年来,无典型口腔癌危险因素的女性口腔癌患者数量一直在增加。临床医生应警惕非吸烟和非酒精妇女口腔黏膜溃疡病变,有利于早期诊断。
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引用次数: 0
Periosteal-secured suture and fixation device in horizontal guided bone regeneration: a retrospective study. 骨膜固定缝合固定装置在水平引导骨再生中的回顾性研究。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-09 DOI: 10.1007/s00784-025-06670-1
Kaio Henrique Soares, Daniel Palkovics, Jairo Evangelista Nascimento, Júlia Gomes Lucio de Araujo, Christopher Dunlevy, Poliana Mendes Duarte

Objectives: The aim of this study was to compare volumetric and linear hard tissue changes, as well as the efficacy of augmentation using periosteal secured suture (PSS) and fixation devices (FD) for resorbable membrane stabilization in horizontal guided bone regeneration (GBR).

Materials and methods: A retrospective matched cohort study was conducted on 14 patients undergoing horizontal GBR, with 7 in each of the PSS and FD (screws/tacks) groups. Inclusion criteria included the availability of high-quality pre- and post-GBR cone beam computed tomography (CBCT) scans and complete documentation of patient- and GBR-related characteristics. Patient-related variables (medical history and demographics) and GBR-related variables (location, type of bone substitute and membrane, and complications) were extracted from dental records. Postoperative CBCT scans were obtained at least 5 months after GBR procedure. CBCT subtraction analysis was performed using spatial registration and semi-automatic segmentation. Outcome variables included volumetric hard tissue gain (primary outcome), volumetric hard tissue loss, efficacy of augmentation (i.e. volumetric gain relative to defect extent), and changes in linear vertical and horizontal hard tissue dimensions between pre- and post-operative scans, measured at the mesial, middle, and distal planes.

Results: Both PSS and FD groups demonstrated significant increases in the linear horizontal dimension from preoperative to postoperative (p < 0.05). The mean horizontal hard tissue gains at 3 mm from the crestal bone in the middle plane were 2.8 ± 1.6 mm for the PSS group and 3.8 ± 1.2 mm for the FD group. The mean volumetric gain and efficacy of augmentation were 0.8 ± 0.9 cm³ and 0.025 ± 0.018 cm³/mm for the PSS group, and 0.6 ± 0.3 cm³ and 0.024 ± 0.010 cm³/mm for the FD group, respectively. No significant differences were observed between groups in linear dimensions, volumetric changes, or efficacy (p > 0.05).

Conclusions: Stabilizing resorbable membranes using periosteal secured sutures or fixation devices in horizontal guided bone regeneration procedures results in comparable linear and volumetric hard tissue gains, demonstrating similar efficacy in hard tissue augmentation.

Clinical relevance: Periosteal secured sutures and fixation devices are both reliable methods for stabilizing resorbable membranes in horizontal guided bone regeneration, yielding comparable efficacy in hard tissue augmentation.

目的:本研究的目的是比较容量和线性硬组织变化,以及在水平引导骨再生(GBR)中使用骨膜固定缝合(PSS)和固定装置(FD)增强可吸收膜稳定的效果。材料和方法:对14例行水平GBR的患者进行回顾性匹配队列研究,PSS组和FD组各7例。纳入标准包括高质量的gbr术前和术后锥形束计算机断层扫描(CBCT)的可用性,以及患者和gbr相关特征的完整文档。从牙科记录中提取患者相关变量(病史和人口统计学)和gbr相关变量(位置、骨替代物和膜的类型以及并发症)。术后CBCT扫描在GBR手术后至少5个月进行。采用空间配准和半自动分割进行CBCT减法分析。结果变量包括体积硬组织增益(主要结果)、体积硬组织损失、增强效果(即相对于缺损程度的体积增益),以及术前和术后扫描中测量的近、中、远平面线性垂直和水平硬组织尺寸的变化。结果:术前与术后,PSS组和FD组的直线水平尺寸均显著增加(p < 0.05)。结论:在水平引导的骨再生手术中,使用骨膜固定缝合线或固定装置稳定可吸收膜,可获得相当的线性和体积硬组织增益,在硬组织增强方面显示出相似的功效。临床意义:骨膜安全缝合线和固定装置都是水平引导骨再生中稳定可吸收膜的可靠方法,在硬组织增强中也有相当的疗效。
{"title":"Periosteal-secured suture and fixation device in horizontal guided bone regeneration: a retrospective study.","authors":"Kaio Henrique Soares, Daniel Palkovics, Jairo Evangelista Nascimento, Júlia Gomes Lucio de Araujo, Christopher Dunlevy, Poliana Mendes Duarte","doi":"10.1007/s00784-025-06670-1","DOIUrl":"10.1007/s00784-025-06670-1","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to compare volumetric and linear hard tissue changes, as well as the efficacy of augmentation using periosteal secured suture (PSS) and fixation devices (FD) for resorbable membrane stabilization in horizontal guided bone regeneration (GBR).</p><p><strong>Materials and methods: </strong>A retrospective matched cohort study was conducted on 14 patients undergoing horizontal GBR, with 7 in each of the PSS and FD (screws/tacks) groups. Inclusion criteria included the availability of high-quality pre- and post-GBR cone beam computed tomography (CBCT) scans and complete documentation of patient- and GBR-related characteristics. Patient-related variables (medical history and demographics) and GBR-related variables (location, type of bone substitute and membrane, and complications) were extracted from dental records. Postoperative CBCT scans were obtained at least 5 months after GBR procedure. CBCT subtraction analysis was performed using spatial registration and semi-automatic segmentation. Outcome variables included volumetric hard tissue gain (primary outcome), volumetric hard tissue loss, efficacy of augmentation (i.e. volumetric gain relative to defect extent), and changes in linear vertical and horizontal hard tissue dimensions between pre- and post-operative scans, measured at the mesial, middle, and distal planes.</p><p><strong>Results: </strong>Both PSS and FD groups demonstrated significant increases in the linear horizontal dimension from preoperative to postoperative (p < 0.05). The mean horizontal hard tissue gains at 3 mm from the crestal bone in the middle plane were 2.8 ± 1.6 mm for the PSS group and 3.8 ± 1.2 mm for the FD group. The mean volumetric gain and efficacy of augmentation were 0.8 ± 0.9 cm³ and 0.025 ± 0.018 cm³/mm for the PSS group, and 0.6 ± 0.3 cm³ and 0.024 ± 0.010 cm³/mm for the FD group, respectively. No significant differences were observed between groups in linear dimensions, volumetric changes, or efficacy (p > 0.05).</p><p><strong>Conclusions: </strong>Stabilizing resorbable membranes using periosteal secured sutures or fixation devices in horizontal guided bone regeneration procedures results in comparable linear and volumetric hard tissue gains, demonstrating similar efficacy in hard tissue augmentation.</p><p><strong>Clinical relevance: </strong>Periosteal secured sutures and fixation devices are both reliable methods for stabilizing resorbable membranes in horizontal guided bone regeneration, yielding comparable efficacy in hard tissue augmentation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 1","pages":"3"},"PeriodicalIF":3.1,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital quantitative analysis of noncarious cervical Lesions, occlusal tooth Wear, and gingival recession: results from a 25-Year clinical Follow-Up study. 非龋齿性宫颈病变、咬合牙磨损和牙龈萎缩的数字定量分析:来自25年临床随访研究的结果。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-09 DOI: 10.1007/s00784-025-06686-7
Caroline Vieira Maluf, Ronaldo Hirata, Eduardo Jose Veras Lourenço, Luis Fernando Pegoraro, Ricardo Guimarães Fischer, Daniel de Moraes Telles

Objectives: To quantitatively evaluate the progression of non-carious cervical lesions (NCCLs), gingival recession (GR), and occlusal tooth wear (OTW) over 25 years.

Methods: This observational, retrospective study involved 33 dental students who completed a questionnaire regarding their oral habits, diet, and health information. Impressions from the baseline and the 25-year follow-up were used to create digital casts, which were analyzed with 3D software (Geomagic Control; 3D Systems) to measure the progression of NCCLs, GR, and OTW. Occlusal analysis from Phase I, using the T-Scan system (Tekscan), was also included to evaluate occlusal interferences.

Results: NCCL dimensions (area, height, and width) showed moderate associations with GR and only weak correlations with OTW. Multivariate regression analyses identified significant factors associated with NCCL progression. For NCCLs, visible plaque, vigorous toothbrushing, occlusal interferences, dentin hypersensitivity, alcohol consumption, smoking, and frequent exposure to acidic or cariogenic diets were associated with increased NCCL progression. For GR, was significantly associated with occlusal contact, dentin hypersensitivity, alcohol consumption, and smoking. For OTW, unilateral mastication, long-term orthodontic treatment, and smoking were positively correlated with wear progression.

Conclusions: Mechanical and behavioral factors-particularly vigorous toothbrushing, occlusal interferences, and lifestyle habits such as smoking and alcohol consumption-significantly influenced the long-term progression of NCCLs, GR, and OTW. Mandibular molars and premolars were the most frequently affected teeth.

Clinical significance: The use of digital three-dimensional analysis allows accurate monitoring of NCCLs, GR, and OTW. Preventive measures should prioritize controllable risk factors, including brushing habits, smoking, alcohol consumption, and occlusal imbalances.

目的:定量评价25年来非龋齿性宫颈病变(ncls)、龈退缩(GR)和咬合牙磨损(OTW)的进展情况。方法:这项观察性、回顾性研究涉及33名牙科学生,他们完成了关于他们的口腔习惯、饮食和健康信息的问卷调查。基线和25年随访的印象用于创建数字模型,并使用3D软件(Geomagic Control; 3D Systems)进行分析,以测量ncls、GR和OTW的进展。使用t扫描系统(Tekscan)进行一期咬合分析,也包括评估咬合干扰。结果:NCCL尺寸(面积、高度和宽度)与GR呈中等相关性,与OTW仅呈弱相关性。多变量回归分析确定了与NCCL进展相关的重要因素。对于NCCL,可见菌斑、强力刷牙、咬合干扰、牙本质过敏、饮酒、吸烟、频繁接触酸性或致龋饮食与NCCL进展增加有关。对于GR,与咬合接触、牙本质过敏、饮酒和吸烟显著相关。对于OTW,单侧咀嚼、长期正畸治疗和吸烟与磨损进展呈正相关。结论:机械和行为因素——尤其是用力刷牙、咬合干扰和生活习惯(如吸烟和饮酒)——显著影响ncls、GR和OTW的长期进展。下颌磨牙和前磨牙是最常受影响的牙齿。临床意义:使用数字三维分析可以准确监测ncls、GR和OTW。预防措施应优先考虑可控制的危险因素,包括刷牙习惯、吸烟、饮酒和咬合不平衡。
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引用次数: 0
Integrating genotype-phenotype correlations into the diagnostic workflow of odontogenic tumors and cysts: insights from a 69 lesion cohort. 将基因型-表型相关性整合到牙源性肿瘤和囊肿的诊断流程中:来自69个病变队列的见解。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-09 DOI: 10.1007/s00784-025-06642-5
Sibel Elif Gültekin, Burcu Toközlü, Carina Heydt, Reinhard Büttner
{"title":"Integrating genotype-phenotype correlations into the diagnostic workflow of odontogenic tumors and cysts: insights from a 69 lesion cohort.","authors":"Sibel Elif Gültekin, Burcu Toközlü, Carina Heydt, Reinhard Büttner","doi":"10.1007/s00784-025-06642-5","DOIUrl":"10.1007/s00784-025-06642-5","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 1","pages":"4"},"PeriodicalIF":3.1,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12689768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional assessment of tooth movements in clear aligner treatment of moderate and severe crowding. 牙齿运动的三维评估在明确对准治疗中度和重度拥挤。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-09 DOI: 10.1007/s00784-025-06657-y
Margaret Eason, Sandra Khong Tai, Charlene Tai Loh, Aron Aliaga Del Castillo, Rodrigo Teixeira, Nathan Hutin, Gaëlle Leroux, Marcela Lima Gurgel, Claudia Trindade Mattos, Antonio Carlos de Oliveira Ruellas, Mary Barkley, Eric Hannapel, Lucia Cevidanes

Objectives: To evaluate angular and linear tooth movements following orthodontic treatment for correction of moderate to severe crowding using clear aligner therapy (CAT).

Materials and methods: This retrospective study included 46 patients treated with clear aligners in permanent dentition for correction of moderate to severe crowding. Twenty-three patients (6 males, 17 females; mean age 20.0 years) were treated with premolar extractions and 23 patients (8 males, 15 females; mean age 17.3 years) were treated without premolar extractions. Three-dimensional tooth linear and angular displacements were quantified in the pre- and post-treatment digital dental models superimposed using the Slicer Automated Dental Tools module of 3D Slicer software ( www.slicer.org ). Generalized estimation equations were used for group comparisons (p < 0.05).

Results: CAT correction of moderate to severe crowding with premolar extraction led to significant retroclination of upper and lower incisors (upper: -6.71° ±7.79, P < 0.001 and lower: -5.11° ±8.49, P < 0.001). Anchorage control in extraction cases was limited, with approximately equal molar mesialization and incisor lingualization. In non-extraction cases, crowding was corrected through arch expansion with flaring of incisors. Vertical changes were similar between groups.

Conclusions: CAT of moderate to severe crowding without extraction led to arch expansion and proclination of incisors. In contrast, premolar extraction cases often presented incisor retroclination and molar mesial tipping, requiring careful biomechanical management.

Clinical relevance: These findings help clinicians plan treatments, manage patient expectations, and anticipate side effects, enabling the use of proper strategies and resources to optimize outcomes in both extraction and non-extraction cases.

目的:评价正畸治疗中至重度拥挤矫治后牙齿的角度和直线运动。材料和方法:本回顾性研究包括46例使用恒牙列透明矫正器矫正中至重度拥挤的患者。23例患者(男性6例,女性17例,平均年龄20.0岁)行前磨牙拔除术;23例患者(男性8例,女性15例,平均年龄17.3岁)不行前磨牙拔除术。使用3D切片器软件(www.slicer.org)的Slicer Automated dental Tools模块在处理前和处理后的数字牙齿模型中对三维牙齿线性和角位移进行量化。采用广义估计方程进行组间比较(p)结果:中度至重度拥挤与前磨牙拔牙的CAT矫正导致上、下门牙明显后倾(上门牙:-6.71°±7.79,p)结论:中度至重度拥挤而不拔牙的CAT导致门牙弓扩张和前倾。相比之下,前磨牙拔牙的病例通常表现为切牙后倾和磨牙中端倾,需要仔细的生物力学处理。临床相关性:这些发现有助于临床医生计划治疗,管理患者的期望,并预测副作用,从而能够使用适当的策略和资源来优化拔牙和非拔牙病例的结果。
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引用次数: 0
Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial. 臭氧治疗对下颌第三磨牙手术拔牙后疼痛的影响:一项裂口随机临床试验。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-09 DOI: 10.1007/s00784-025-06681-y
Luca Guaschino, Alessandro Vanzanelli, Piermarco Babando, Andrea Ricotti, Guglielmo Amedeo Ramieri, Andrea Roccuzzo, Paolo Appendino

Objectives: To evaluate the efficacy of ozone therapy on pain reduction, trisma and number of analgesic tablets taken following surgical removal of impacted mandibular third molar.

Methods: A split-mouth randomized clinical trial was conducted in 54 patients in need of bilateral impacted mandibular third molars (Pell-Gregory class II-B) extraction. Test sites were treated with adjunctive ozone therapy to the surgical extraction, while controls underwent surgical intervention only (time between surgeries: 3 weeks). Study primary outcome measure was the difference in perceived pain recorded using a Numerical Rating Scale (NRS) at 7 days after surgery. In addition, functional limitation in mouth opening (mm), number of analgesic tablets taken within one week after surgery as well as the patient's perceived quality of life (Oral Health Impact Profile (OHIP-14) were evaluated.

Results: Fifty patients (20 males and 30 females; median age: 21 years; all non-smokers) completed the study. Mean reported perceived pain decrease from 5.06 to 0.58 (test group) and from 5.62 to 1.08 (control group) between day 1 and 7. No statistically significant differences were detected between the two groups at any time points (p > 0.05). At day 7, mean mouth opening value was 40.8 vs. 36.6 mm in test and control group respectively (mean difference: 4.24 mm; p < 0.001; 95% CI: 6.55-1.93). The same trend was detected for the of number of analgesic tablets taken (median: 4 vs. 7; p = 0.01). Finally, OHIP-14 values did not differ between groups (p > 0.05).

Conclusion: Ozone therapy had a beneficial clinical effect in terms of mouth opening and in the number of analgesic tablets intake at 7 days after surgical removal of impacted mandibular third molar, despite the lack of adjunctive benefit on patients perceived pain reduction.

Clinical relevance: The clinical use of ozone therapy as adjunct to surgical removal of impacted mandibular third molar might be considered in light of the promising positive reported results in terms of mouth opening reduction and analgesic intake.

Clinical trial registration number: NCT05949476.

目的:评价臭氧治疗对下颌阻生第三磨牙拔除术后疼痛减轻、疼痛缓解及镇痛片用量的影响。方法:对54例双侧下颌阻生第三磨牙(pel - gregory II-B类)拔除患者进行裂口随机临床试验。试验部位在手术摘除后进行辅助臭氧治疗,而对照组仅进行手术干预(手术间隔时间:3周)。研究的主要结果测量是术后7天用数值评定量表(NRS)记录的感知疼痛的差异。此外,还评估了开口功能限制(mm)、术后一周内服用镇痛片的数量以及患者的感知生活质量(口腔健康影响概况(OHIP-14))。结果:50例患者(男性20例,女性30例,中位年龄21岁,均为非吸烟者)完成了研究。第1天至第7天,平均报告疼痛从5.06降至0.58(试验组),从5.62降至1.08(对照组)。两组在各时间点差异均无统计学意义(p < 0.05)。第7天,试验组和对照组的平均开口值分别为40.8 mm和36.6 mm(平均差4.24 mm, p 0.05)。结论:臭氧治疗在下颌阻生第三磨牙手术切除后7天的开口和镇痛片摄入量方面具有良好的临床效果,尽管在患者感知疼痛减轻方面缺乏辅助益处。临床相关性:鉴于在减少开口和镇痛摄入方面有希望的积极报道结果,可以考虑临床使用臭氧治疗作为手术切除下颌阻生第三磨牙的辅助手段。临床试验注册号:NCT05949476。
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引用次数: 0
Transdentinal effects of flavonoid-based primers applied to caries-affected dentin on pulp cells. 黄酮类引物对龋病牙本质对牙髓细胞的影响。
IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-08 DOI: 10.1007/s00784-025-06693-8
Beatriz Ometto Sahadi, Igor Paulino Mendes Soares, Chloe Gifford, Caroline Anselmi, Josimeri Hebling, Marcelo Giannini, Marco C Bottino

Objective: To examine the transdentinal response of odontoblast-like cells (MDPC-23), dental pulp stem cells (DPSC), and macrophages to flavonoid-based primers applied to caries-affected dentin.

Materials and methods: Primers were prepared from 20 mM of Naringin, Kaempferol, or Baicalein in 20% ethanol. Caries-affected dentin discs (N = 56) were produced using a microcosm biofilm model and mounted in artificial pulp chambers with MDPC-23 cells seeded on the pulp side. Occlusal surfaces (n = 8) were etched with 35% phosphoric acid, rinsed, and blot-dried, followed by application of ultrapure water (negative control, NC), 20% ethanol (solvent control, SC), flavonoid primers, or 29% hydrogen peroxide (positive control, PC). After 24 h, cell viability and morphology (scanning electron microscopy, SEM) were evaluated. Extracts obtained by transdentinal diffusion were applied to DPSC and MDPC-23 cells for up to 7 days to assess cell viability and mineralization, and to macrophages (RAW 264.7) for reactive oxygen species (ROS) production. Data were analyzed using ANOVA and Sidak's test (α = 5%).

Results: None of the flavonoid primers reduced MDPC-23 viability, while PC and phosphoric acid showed significant differences from NC. SEM images revealed altered cell morphology in acid-etched groups. After 7 days, primers slightly increased DPSC viability, maintained MDPC-23 viability, promoted mineralization, and reduced ROS.

Conclusions: Flavonoid-based primers applied to caries-affected dentin were non-cytotoxic, stimulated mineralization in pulp cells, and lowered oxidative stress in macrophages.

Clinical relevance: Flavonoid primers could support pulp health during dentin pretreatment, providing a conservative strategy for managing caries-affected dentin and reducing the risk of pulp irritation.

目的:观察成牙细胞样细胞(MDPC-23)、牙髓干细胞(DPSC)和巨噬细胞对黄酮类引物对龋损牙本质的反应。材料与方法:以柚皮苷、山奈酚、黄芩苷为原料,用20%乙醇溶液分别制备20 mM引物。采用微型生物膜模型制作受龋影响的牙本质盘(N = 56),并在牙髓侧植入MDPC-23细胞,安装在人工牙髓腔内。咬合表面(n = 8)用35%磷酸蚀刻、冲洗、斑点干燥,然后应用超纯水(阴性对照,NC)、20%乙醇(溶剂对照,SC)、类黄酮引物或29%过氧化氢(阳性对照,PC)。24 h后,观察细胞活力和形态(扫描电镜)。经牙髓扩散获得的提取物应用于DPSC和MDPC-23细胞长达7天,以评估细胞活力和矿化,并应用于巨噬细胞(RAW 264.7)以产生活性氧(ROS)。数据分析采用方差分析和Sidak检验(α = 5%)。结果:所有类黄酮引物均未降低MDPC-23活性,而PC和磷酸与NC差异显著。扫描电镜图像显示酸蚀组细胞形态改变。7天后,引物略微提高DPSC活力,维持MDPC-23活力,促进矿化,降低ROS。结论:黄酮类引物对龋损牙本质无细胞毒性,可刺激牙髓细胞矿化,降低巨噬细胞氧化应激。临床意义:黄酮类引物可以在牙本质预处理过程中支持牙本质健康,为治疗龋齿影响的牙本质提供了一种保守的策略,降低了牙本质刺激的风险。
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引用次数: 0
期刊
Clinical Oral Investigations
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