Pub Date : 2025-03-25DOI: 10.1016/j.colcom.2025.100833
Jin Liu , Tianle Liu , Chi Zhang , Ziyou Wang , Xinyi Zhang , Chuanchuan Hao , Dan Wang , Guohui Cheng
By focusing on mitochondria as a therapeutic target, strategies can be devised to deplete ATP levels, thereby potentially circumventing the emergence of MDR. In this study, we developed a surface-modified hyaluronic acid (HA), mitochondrial targeted hollow mesoporous silicon nanomedicine (PB@HMSN-HA) co-loaded with berberine (BBR) and paclitaxel (PTX) for enhanced colorectal cancer therapy. The modified HA can selectively bind to tumor cells that overexpress the CD44 receptor, leading to the accumulation of PB@HMSN-HA at the tumor site and improving tumor targeting efficiency. After cellular internalization, the liberated positively charged BBR, which is specifically targeted to mitochondria, induces a reduction in ATP levels. Depletion of ATP subsequently results in a reduction of drug efflux, thereby amplifying the antitumor efficacy of PTX. Therefore, this combination therapy strategy targeting mitochondria serves as an important reference for clinical oncological chemotherapy.
{"title":"A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy","authors":"Jin Liu , Tianle Liu , Chi Zhang , Ziyou Wang , Xinyi Zhang , Chuanchuan Hao , Dan Wang , Guohui Cheng","doi":"10.1016/j.colcom.2025.100833","DOIUrl":"10.1016/j.colcom.2025.100833","url":null,"abstract":"<div><div>By focusing on mitochondria as a therapeutic target, strategies can be devised to deplete ATP levels, thereby potentially circumventing the emergence of MDR. In this study, we developed a surface-modified hyaluronic acid (HA), mitochondrial targeted hollow mesoporous silicon nanomedicine (PB@HMSN-HA) co-loaded with berberine (BBR) and paclitaxel (PTX) for enhanced colorectal cancer therapy. The modified HA can selectively bind to tumor cells that overexpress the CD44 receptor, leading to the accumulation of PB@HMSN-HA at the tumor site and improving tumor targeting efficiency. After cellular internalization, the liberated positively charged BBR, which is specifically targeted to mitochondria, induces a reduction in ATP levels. Depletion of ATP subsequently results in a reduction of drug efflux, thereby amplifying the antitumor efficacy of PTX. Therefore, this combination therapy strategy targeting mitochondria serves as an important reference for clinical oncological chemotherapy.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100833"},"PeriodicalIF":4.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.
{"title":"Smart self-assembled nanomedicine for ferroptotic tumor therapy","authors":"Chen Liang , Tian Zhang , Qingming Zhang , Xiaozhou Mou","doi":"10.1016/j.colcom.2025.100829","DOIUrl":"10.1016/j.colcom.2025.100829","url":null,"abstract":"<div><div>Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100829"},"PeriodicalIF":4.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-15DOI: 10.1016/j.colcom.2025.100827
Teodora Despotovski , Slavica Mitrović , Nikola Knežević , Milan Vraneš , Lidija Petrović , Marko Pavlović
Argentometric titrations are traditional and widely recognized methods for detecting halide ions. However, their practical application is often constrained by challenges such as pH control and reliance on specific indicators. In this study, we introduce a novel optical indicator for argentometric titration, based on previously reported Janus droplet systems and employing cetyltrimethylammonium bromide (CTAB) and Zonyl as surfactants. Furthermore, Janus droplets were utilized to explore the impact of various cations on the efficiency of the CTAB surfactant, revealing that contact angle values are influenced by the cations' positions within the Hofmeister series.
{"title":"Responsive Janus emulsion as an unconventional indicator for a traditional argentometric titration","authors":"Teodora Despotovski , Slavica Mitrović , Nikola Knežević , Milan Vraneš , Lidija Petrović , Marko Pavlović","doi":"10.1016/j.colcom.2025.100827","DOIUrl":"10.1016/j.colcom.2025.100827","url":null,"abstract":"<div><div>Argentometric titrations are traditional and widely recognized methods for detecting halide ions. However, their practical application is often constrained by challenges such as pH control and reliance on specific indicators. In this study, we introduce a novel optical indicator for argentometric titration, based on previously reported Janus droplet systems and employing cetyltrimethylammonium bromide (CTAB) and Zonyl as surfactants. Furthermore, Janus droplets were utilized to explore the impact of various cations on the efficiency of the CTAB surfactant, revealing that contact angle values are influenced by the cations' positions within the Hofmeister series.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100827"},"PeriodicalIF":4.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-10DOI: 10.1016/j.colcom.2025.100828
Hongwei Pan , Yue Qu , Feng Wang , Shengbing Zhao , Gaigai Chen
In clinical practice, addressing severe bone defects resulting from trauma, tumors, infections or congenital disorders remains a challenge in the surgical domain. Although bone tissue has a certain capacity for self-repair, artificial substitute materials of bone are still required to facilitate the repair, especially for large-scale bone defects. At present, tissue engineering-related materials that mimic the structure, mechanical properties, and biological characteristics of natural bone have been widely used for addressing bone defects and promoting in situ bone regeneration. Hydrogels that emulate the properties of the extracellular matrix are prevalent materials in bone tissue engineering, with a particular emphasis on those crosslinked through HRP-mediated, which have garnered considerable interest due to their high efficiency of preparation, mild reaction conditions, controllable properties, and excellent biocompatibility. However, the suboptimal osteogenic capability inherent in HRP-mediated crosslinked hydrogels necessitates the integration of additional osteogenic activity materials, such as biological calcium phosphates, biomimetic scaffolds, growth factors, synthetic peptides, and nanomaterials, to bolster the hydrogel scaffolds' osteogenic potential. This manuscript provides a concise overview of the standard methodologies for crafting injectable hydrogels, highlighting the HRP catalytic reaction mechanism, and strategies for modulating hydrogel attributes. Furthermore, this paper delves into the recent advancements in HRP-mediated crosslinked hydrogel scaffolds, highlighting their role in bone defect repair within the realm of bone tissue engineering. These insights establish a robust foundation for the innovation, development, and clinical application of bone tissue substitutes that prioritize biosafety.
{"title":"Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration","authors":"Hongwei Pan , Yue Qu , Feng Wang , Shengbing Zhao , Gaigai Chen","doi":"10.1016/j.colcom.2025.100828","DOIUrl":"10.1016/j.colcom.2025.100828","url":null,"abstract":"<div><div>In clinical practice, addressing severe bone defects resulting from trauma, tumors, infections or congenital disorders remains a challenge in the surgical domain. Although bone tissue has a certain capacity for self-repair, artificial substitute materials of bone are still required to facilitate the repair, especially for large-scale bone defects. At present, tissue engineering-related materials that mimic the structure, mechanical properties, and biological characteristics of natural bone have been widely used for addressing bone defects and promoting in situ bone regeneration. Hydrogels that emulate the properties of the extracellular matrix are prevalent materials in bone tissue engineering, with a particular emphasis on those crosslinked through HRP-mediated, which have garnered considerable interest due to their high efficiency of preparation, mild reaction conditions, controllable properties, and excellent biocompatibility. However, the suboptimal osteogenic capability inherent in HRP-mediated crosslinked hydrogels necessitates the integration of additional osteogenic activity materials, such as biological calcium phosphates, biomimetic scaffolds, growth factors, synthetic peptides, and nanomaterials, to bolster the hydrogel scaffolds' osteogenic potential. This manuscript provides a concise overview of the standard methodologies for crafting injectable hydrogels, highlighting the HRP catalytic reaction mechanism, and strategies for modulating hydrogel attributes. Furthermore, this paper delves into the recent advancements in HRP-mediated crosslinked hydrogel scaffolds, highlighting their role in bone defect repair within the realm of bone tissue engineering. These insights establish a robust foundation for the innovation, development, and clinical application of bone tissue substitutes that prioritize biosafety.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100828"},"PeriodicalIF":4.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.colcom.2025.100824
Vladimir Rosenov Koynarev , Thomas Daniel Vogelaar , Mahmoud Moqadam , Nathalie Reuter , Reidar Lund
Antimicrobial peptides (AMPs) have shown great potential against the ongoing rise of multi-drug resistant bacteria because of their high potency and effectiveness. Their clinical utility has, however, remained limited due to their severe side effects. As an exception, colistin (polymyxin E) is currently utilized as a last-resort option against severe gram-negative infections despite being cyto- and nephrotoxic. The ongoing efforts to reduce these side effects are hampered by the generally poor understanding of its mode of action and behavior in solution. A key question that has been debated is whether colistin self-assembles into micelles or remains as unimers in solution. Herein, we used synchrotron small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and molecular dynamics (MD) to show that colistin does not self-assemble in a wide range of physiologically relevant conditions. These contrasting findings, compared to previously reported results, provide important new insights into the behavior of colistin, aiding the understanding and potential improvement of this relevant AMP-based antibiotic.
{"title":"Colistin does not self-assemble at physiologically relevant conditions","authors":"Vladimir Rosenov Koynarev , Thomas Daniel Vogelaar , Mahmoud Moqadam , Nathalie Reuter , Reidar Lund","doi":"10.1016/j.colcom.2025.100824","DOIUrl":"10.1016/j.colcom.2025.100824","url":null,"abstract":"<div><div>Antimicrobial peptides (AMPs) have shown great potential against the ongoing rise of multi-drug resistant bacteria because of their high potency and effectiveness. Their clinical utility has, however, remained limited due to their severe side effects. As an exception, colistin (polymyxin E) is currently utilized as a last-resort option against severe gram-negative infections despite being cyto- and nephrotoxic. The ongoing efforts to reduce these side effects are hampered by the generally poor understanding of its mode of action and behavior in solution. A key question that has been debated is whether colistin self-assembles into micelles or remains as unimers in solution. Herein, we used synchrotron small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and molecular dynamics (MD) to show that colistin <em>does not</em> self-assemble in a wide range of physiologically relevant conditions. These contrasting findings, compared to previously reported results, provide important new insights into the behavior of colistin, aiding the understanding and potential improvement of this relevant AMP-based antibiotic.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100824"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interaction between macroscopic fluid flow and nanoscale forces has resulted in the formation of long-range assemblies through evaporation-induced self-assembly. Anisotropic gold nanorods (AuNR) can form disordered, smectic, or vertically ordered long-range structures, but controlling their assembly remains a challenge and requires a deeper understanding of fundamental interaction mechanisms. In this work, we established a correlation between the in situ drying profiles, measured using an optical tensiometer, and deposit pattern, imaged ex situ using electron microscopy. Increasing particle concentration induced a transition from coffee-ring to uniform deposition at the microscale, while nanoscale structures shifted from isotropic/smectic to vertically aligned crystalline AuNRs. The interplay of capillary and Marangoni flow influences assembly at both macro and nanoscales, with the deposition process and nanoparticle ordering being highly sensitive to interparticle and nanoparticle-substrate interactions. By systematically studying key parameters, we aim to develop a comprehensive framework for the rational design and fabrication of nanomaterials with precisely controlled structure and properties.
{"title":"Role of fluid forces and depletion interactions in directing assembly of aqueous gold nanorods on hydrophobic surfaces","authors":"N.P. Vaisakh , Suman Bhattacharjee , Sunita Srivastava","doi":"10.1016/j.colcom.2025.100825","DOIUrl":"10.1016/j.colcom.2025.100825","url":null,"abstract":"<div><div>The interaction between macroscopic fluid flow and nanoscale forces has resulted in the formation of long-range assemblies through evaporation-induced self-assembly. Anisotropic gold nanorods (AuNR) can form disordered, smectic, or vertically ordered long-range structures, but controlling their assembly remains a challenge and requires a deeper understanding of fundamental interaction mechanisms. In this work, we established a correlation between the <em>in situ</em> drying profiles, measured using an optical tensiometer, and deposit pattern, imaged <em>ex situ</em> using electron microscopy. Increasing particle concentration induced a transition from coffee-ring to uniform deposition at the microscale, while nanoscale structures shifted from isotropic/smectic to vertically aligned crystalline AuNRs. The interplay of capillary and Marangoni flow influences assembly at both macro and nanoscales, with the deposition process and nanoparticle ordering being highly sensitive to interparticle and nanoparticle-substrate interactions. By systematically studying key parameters, we aim to develop a comprehensive framework for the rational design and fabrication of nanomaterials with precisely controlled structure and properties.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100825"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study explores the stabilization mechanisms of concentrated emulsions with tunable morphology using amphiphilic polymer-grafted nanoparticles (PGNPs). We employ coarse-grained molecular simulations to investigate concentrated oil-in-water emulsions stabilized by partially hydrolyzed poly(vinyl alcohol)-grafted poly(methyl methacrylate) (PMMA) particles. Two grafting architectures were examined: hydrophilic-hydrophobic (AB-type) diblock PGNPs and reverse BA-type diblock PGNPs. Our findings reveal that AB-type diblock PGNPs tend to aggregate, leading to droplet-droplet coalescence. In contrast, BA-type diblock PGNPs disperse effectively in the water phase, stabilizing robust emulsion through a space-filling mechanism. The study further demonstrates that the stability and morphology of the emulsions can be tuned by varying the number of PGNPs. Our results suggest that BA-type diblock PGNPs are more effective in stabilizing concentrated emulsions, offering insights for the design of novel emulsifiers in industrial applications.
{"title":"Effects of grafting architecture of amphiphilic polymer-grafted nanoparticles on stabilization mechanisms of concentrated emulsions","authors":"Kojiro Suzuki , Yusei Kobayashi , Takashi Yamazaki , Toshikazu Tsuji , Noriyoshi Arai","doi":"10.1016/j.colcom.2025.100822","DOIUrl":"10.1016/j.colcom.2025.100822","url":null,"abstract":"<div><div>This study explores the stabilization mechanisms of concentrated emulsions with tunable morphology using amphiphilic polymer-grafted nanoparticles (PGNPs). We employ coarse-grained molecular simulations to investigate concentrated oil-in-water emulsions stabilized by partially hydrolyzed poly(vinyl alcohol)-grafted poly(methyl methacrylate) (PMMA) particles. Two grafting architectures were examined: hydrophilic-hydrophobic (AB-type) diblock PGNPs and reverse BA-type diblock PGNPs. Our findings reveal that AB-type diblock PGNPs tend to aggregate, leading to droplet-droplet coalescence. In contrast, BA-type diblock PGNPs disperse effectively in the water phase, stabilizing robust emulsion through a space-filling mechanism. The study further demonstrates that the stability and morphology of the emulsions can be tuned by varying the number of PGNPs. Our results suggest that BA-type diblock PGNPs are more effective in stabilizing concentrated emulsions, offering insights for the design of novel emulsifiers in industrial applications.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100822"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-25DOI: 10.1016/j.colcom.2025.100826
Radhika Joshi , Swapnil Sharma , Nemat Ali , Ghazala Muteeb , Mohammad Fareed , Prawez Alam , Devesh U. Kapoor , Bhupendra G. Prajapati
Nanoprisms, a distinctive class of nanostructures, have garnered significant attention in nanomedicine due to their exceptional optical, electronic, and physicochemical properties. This review highlights the diagnostic and therapeutic potential of nanoprisms, emphasizing their transformative role in modern healthcare. First, it provides an overview of current diagnostic and therapeutic strategies within nanomedicine and underscores the unique attributes of nanoprisms. The synthesis and functionalization of nanoprisms, including seed-mediated growth and surface modification techniques like PEGylation and ligand conjugation, are discussed, showcasing how size, shape, and material composition influence their applications. Their diagnostic capabilities span bioimaging techniques, such as plasmonic and photoacoustic imaging, molecular diagnostics, and pathogen detection. In therapeutics, nanoprisms excel in photothermal cancer therapy, targeted drug delivery, and antimicrobial applications, including combating multidrug-resistant strains. Finally, the review addresses existing challenges and future opportunities in advancing nanoprism-based technologies, paving the way for innovative solutions in diagnostics and therapy.
{"title":"Harnessing the potential of nanoprisms for diagnostic and therapeutic applications","authors":"Radhika Joshi , Swapnil Sharma , Nemat Ali , Ghazala Muteeb , Mohammad Fareed , Prawez Alam , Devesh U. Kapoor , Bhupendra G. Prajapati","doi":"10.1016/j.colcom.2025.100826","DOIUrl":"10.1016/j.colcom.2025.100826","url":null,"abstract":"<div><div>Nanoprisms, a distinctive class of nanostructures, have garnered significant attention in nanomedicine due to their exceptional optical, electronic, and physicochemical properties. This review highlights the diagnostic and therapeutic potential of nanoprisms, emphasizing their transformative role in modern healthcare. First, it provides an overview of current diagnostic and therapeutic strategies within nanomedicine and underscores the unique attributes of nanoprisms. The synthesis and functionalization of nanoprisms, including seed-mediated growth and surface modification techniques like PEGylation and ligand conjugation, are discussed, showcasing how size, shape, and material composition influence their applications. Their diagnostic capabilities span bioimaging techniques, such as plasmonic and photoacoustic imaging, molecular diagnostics, and pathogen detection. In therapeutics, nanoprisms excel in photothermal cancer therapy, targeted drug delivery, and antimicrobial applications, including combating multidrug-resistant strains. Finally, the review addresses existing challenges and future opportunities in advancing nanoprism-based technologies, paving the way for innovative solutions in diagnostics and therapy.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100826"},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/j.colcom.2025.100823
Iaan Cho , Jiho Yang , Shimeles Shumi Raya , Bonggeun Shong
Two-dimensional (2D) materials, such as molybdenum disulfide (MoS2), have gained considerable attention for future electronic applications because of their exceptional characteristics with atomic-scale thickness. However, uniform deposition of dielectric materials such as aluminum oxide (Al2O3) on 2D materials remains challenging because of the chemically inert nature of these surfaces. In this study, the adsorption behaviors of aluminum ALD precursors on MoS2 substrates were investigated using density functional theory (DFT) calculations. The results show that the physisorption of the popular trimethylaluminum (TMA) precursor shows low thermodynamic stability, whereas larger molecules such as aluminum triisopropoxide (ATIP) and triisobutylaluminum (TIBA) display greater stability for physisorption, suggesting better nucleation in ALD. While physisorption of these precursors is more stable on the basal plane than on the edge sites of MoS2, edge sites may be preferred for dissociative chemisorption.
{"title":"Adsorption of aluminum precursors on MoS2 toward nucleation of atomic layer deposition","authors":"Iaan Cho , Jiho Yang , Shimeles Shumi Raya , Bonggeun Shong","doi":"10.1016/j.colcom.2025.100823","DOIUrl":"10.1016/j.colcom.2025.100823","url":null,"abstract":"<div><div>Two-dimensional (2D) materials, such as molybdenum disulfide (MoS<sub>2</sub>), have gained considerable attention for future electronic applications because of their exceptional characteristics with atomic-scale thickness. However, uniform deposition of dielectric materials such as aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) on 2D materials remains challenging because of the chemically inert nature of these surfaces. In this study, the adsorption behaviors of aluminum ALD precursors on MoS<sub>2</sub> substrates were investigated using density functional theory (DFT) calculations. The results show that the physisorption of the popular trimethylaluminum (TMA) precursor shows low thermodynamic stability, whereas larger molecules such as aluminum triisopropoxide (ATIP) and triisobutylaluminum (TIBA) display greater stability for physisorption, suggesting better nucleation in ALD. While physisorption of these precursors is more stable on the basal plane than on the edge sites of MoS<sub>2</sub>, edge sites may be preferred for dissociative chemisorption.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100823"},"PeriodicalIF":4.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-11DOI: 10.1016/j.colcom.2025.100820
Jing Ma , Yu Tian , Yibiao Chen , Xiaodan Zhang , Chenyu Ding , Zhangya Lin
Ischemia-reperfusion injury is a major threat in ischemic stroke, with limited treatment options. Edaravone, a first-line drug, has multiple limitations, and the narrow time window for reperfusion therapy complicates treatment. This study reports a nanoparticle drug designed to mitigate ischemia-reperfusion injury by targeting inflammation. The drug is made of mesoporous silica (SiO2) loaded with the CO-releasing molecule CORM-401 and coated with a macrophage membrane (MM) shell. The nanoparticles effectively cross the blood-brain barrier and target ischemic brain lesions. In vitro and in vivo studies show that SiO2@MM@CORM-401 scavenges reactive oxygen species (ROS), promotes anti-inflammatory factor release, and inhibits pro-inflammatory factors. Additionally, CO helps prevent ferroptosis in the ischemic penumbra, offering a potential mechanism for alleviating ischemic stroke and providing a novel therapeutic approach.
{"title":"Loaded endogenous CO mimetic nanomedicine mitigates ischemic stroke ischemia-reperfusion injury","authors":"Jing Ma , Yu Tian , Yibiao Chen , Xiaodan Zhang , Chenyu Ding , Zhangya Lin","doi":"10.1016/j.colcom.2025.100820","DOIUrl":"10.1016/j.colcom.2025.100820","url":null,"abstract":"<div><div>Ischemia-reperfusion injury is a major threat in ischemic stroke, with limited treatment options. Edaravone, a first-line drug, has multiple limitations, and the narrow time window for reperfusion therapy complicates treatment. This study reports a nanoparticle drug designed to mitigate ischemia-reperfusion injury by targeting inflammation. The drug is made of mesoporous silica (SiO2) loaded with the CO-releasing molecule CORM-401 and coated with a macrophage membrane (MM) shell. The nanoparticles effectively cross the blood-brain barrier and target ischemic brain lesions. In vitro and in vivo studies show that SiO2@MM@CORM-401 scavenges reactive oxygen species (ROS), promotes anti-inflammatory factor release, and inhibits pro-inflammatory factors. Additionally, CO helps prevent ferroptosis in the ischemic penumbra, offering a potential mechanism for alleviating ischemic stroke and providing a novel therapeutic approach.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100820"},"PeriodicalIF":4.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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