Pub Date : 2025-05-01Epub Date: 2025-04-18DOI: 10.1016/j.colcom.2025.100837
Shaveen Fernando, Surita R. Bhatia
This work explores stratification, a prescribed spatial variation of components in a multi-component film, in particle-polymer films prepared by a single-step evaporative drying technique. Our overall goal is to develop a more efficient and cost-effective way to create vertically structured multi-component polymer and colloid films. Films containing poly(acrylic acid) (PAA) chains and polystyrene (PS) colloidal nanoparticles were analyzed using microbeam small-angle X-ray scattering (SAXS) and atomic force microscopy (AFM) to probe the impact of evaporation rates and colloid sizes on stratification behavior. Under slow drying conditions, particle-on-top stratification was observed, consistent with a diffusive model of stratification behavior. Conversely, moderate evaporation rates resulted in non-stratified configurations for certain mixtures. Fast evaporation, achieved by drying at elevated temperatures, induced polymer-on-top stratification, which aligns with predictions from simulations. Overall, this study proposes a more efficient method for creating vertically structured films, with implications for various industries.
{"title":"Scalable manufacturing of layered nanoparticle-polymer composite films through evaporative assembly","authors":"Shaveen Fernando, Surita R. Bhatia","doi":"10.1016/j.colcom.2025.100837","DOIUrl":"10.1016/j.colcom.2025.100837","url":null,"abstract":"<div><div>This work explores stratification, a prescribed spatial variation of components in a multi-component film, in particle-polymer films prepared by a single-step evaporative drying technique. Our overall goal is to develop a more efficient and cost-effective way to create vertically structured multi-component polymer and colloid films. Films containing poly(acrylic acid) (PAA) chains and polystyrene (PS) colloidal nanoparticles were analyzed using microbeam small-angle X-ray scattering (SAXS) and atomic force microscopy (AFM) to probe the impact of evaporation rates and colloid sizes on stratification behavior. Under slow drying conditions, particle-on-top stratification was observed, consistent with a diffusive model of stratification behavior. Conversely, moderate evaporation rates resulted in non-stratified configurations for certain mixtures. Fast evaporation, achieved by drying at elevated temperatures, induced polymer-on-top stratification, which aligns with predictions from simulations. Overall, this study proposes a more efficient method for creating vertically structured films, with implications for various industries.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100837"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-09DOI: 10.1016/j.colcom.2025.100836
Rebeca Fortes Martín, Sibylle Rustig, Ilko Bald, Joachim Koetz
A simplified procedure for the surface assembly of oleyl-capped nanoparticles from water-in-oil microemulsions is presented. Changing the heptane-to-pentanol ratio in the oil phase resulted in different surface assemblies. Remarkably, a minor proportion of heptane in pentanol enabled the formation of filament networks, without the assistance of other additives for clustering effects.
{"title":"Tuning surface assembly of oleyl-capped nanoparticles in AOT microemulsion phase with optimal alkane-to-alkanol ratio","authors":"Rebeca Fortes Martín, Sibylle Rustig, Ilko Bald, Joachim Koetz","doi":"10.1016/j.colcom.2025.100836","DOIUrl":"10.1016/j.colcom.2025.100836","url":null,"abstract":"<div><div>A simplified procedure for the surface assembly of oleyl-capped nanoparticles from water-in-oil microemulsions is presented. Changing the heptane-to-pentanol ratio in the oil phase resulted in different surface assemblies. Remarkably, a minor proportion of heptane in pentanol enabled the formation of filament networks, without the assistance of other additives for clustering effects.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100836"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-10DOI: 10.1016/j.colcom.2025.100828
Hongwei Pan , Yue Qu , Feng Wang , Shengbing Zhao , Gaigai Chen
In clinical practice, addressing severe bone defects resulting from trauma, tumors, infections or congenital disorders remains a challenge in the surgical domain. Although bone tissue has a certain capacity for self-repair, artificial substitute materials of bone are still required to facilitate the repair, especially for large-scale bone defects. At present, tissue engineering-related materials that mimic the structure, mechanical properties, and biological characteristics of natural bone have been widely used for addressing bone defects and promoting in situ bone regeneration. Hydrogels that emulate the properties of the extracellular matrix are prevalent materials in bone tissue engineering, with a particular emphasis on those crosslinked through HRP-mediated, which have garnered considerable interest due to their high efficiency of preparation, mild reaction conditions, controllable properties, and excellent biocompatibility. However, the suboptimal osteogenic capability inherent in HRP-mediated crosslinked hydrogels necessitates the integration of additional osteogenic activity materials, such as biological calcium phosphates, biomimetic scaffolds, growth factors, synthetic peptides, and nanomaterials, to bolster the hydrogel scaffolds' osteogenic potential. This manuscript provides a concise overview of the standard methodologies for crafting injectable hydrogels, highlighting the HRP catalytic reaction mechanism, and strategies for modulating hydrogel attributes. Furthermore, this paper delves into the recent advancements in HRP-mediated crosslinked hydrogel scaffolds, highlighting their role in bone defect repair within the realm of bone tissue engineering. These insights establish a robust foundation for the innovation, development, and clinical application of bone tissue substitutes that prioritize biosafety.
{"title":"Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration","authors":"Hongwei Pan , Yue Qu , Feng Wang , Shengbing Zhao , Gaigai Chen","doi":"10.1016/j.colcom.2025.100828","DOIUrl":"10.1016/j.colcom.2025.100828","url":null,"abstract":"<div><div>In clinical practice, addressing severe bone defects resulting from trauma, tumors, infections or congenital disorders remains a challenge in the surgical domain. Although bone tissue has a certain capacity for self-repair, artificial substitute materials of bone are still required to facilitate the repair, especially for large-scale bone defects. At present, tissue engineering-related materials that mimic the structure, mechanical properties, and biological characteristics of natural bone have been widely used for addressing bone defects and promoting in situ bone regeneration. Hydrogels that emulate the properties of the extracellular matrix are prevalent materials in bone tissue engineering, with a particular emphasis on those crosslinked through HRP-mediated, which have garnered considerable interest due to their high efficiency of preparation, mild reaction conditions, controllable properties, and excellent biocompatibility. However, the suboptimal osteogenic capability inherent in HRP-mediated crosslinked hydrogels necessitates the integration of additional osteogenic activity materials, such as biological calcium phosphates, biomimetic scaffolds, growth factors, synthetic peptides, and nanomaterials, to bolster the hydrogel scaffolds' osteogenic potential. This manuscript provides a concise overview of the standard methodologies for crafting injectable hydrogels, highlighting the HRP catalytic reaction mechanism, and strategies for modulating hydrogel attributes. Furthermore, this paper delves into the recent advancements in HRP-mediated crosslinked hydrogel scaffolds, highlighting their role in bone defect repair within the realm of bone tissue engineering. These insights establish a robust foundation for the innovation, development, and clinical application of bone tissue substitutes that prioritize biosafety.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100828"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-09DOI: 10.1016/j.colcom.2025.100835
Huidan Wei , Jing Wen , Sai Yan , Han Zhang , Yuan Liu , Yuhan Xia , Jidong Li , Ran Cao , Meifang Zhu
Surface topography and mechanical properties of wound dressing significantly influence cell behavior and tissue regeneration process. Skin has unique textures, which are often overlooked in the preparation of wound dressings. Herein, we fabricated biomimetic wound dressings by transferring the surface textures of skin through electrospinning technology. Specifically, the top and bottom surface of pig skin employed as substrates for the collection of electrospinning nanofibers composed of polylactic acid and gelatin (PLLA/GL). Due to the existence of hair on the top surface of pig skin, the transferred nanofiber membrane (skin-top) exhibited scattered small pores (∼50 μm). In contrast, the transferred nanofiber membrane with aluminum foil (Al) as substrate displayed a smooth surface. Benefit from the unique surface properties of skin, the skin-based nanofiber membrane demonstrated improved roughness and enhanced air permeability. Specifically, skin-top based wound dressing showed the best performance in promoting wound healing, including enhanced epithelialization and collagen deposition.
{"title":"Adjusting morphologies of wound dressing by transferring skin textures through electrospinning technology","authors":"Huidan Wei , Jing Wen , Sai Yan , Han Zhang , Yuan Liu , Yuhan Xia , Jidong Li , Ran Cao , Meifang Zhu","doi":"10.1016/j.colcom.2025.100835","DOIUrl":"10.1016/j.colcom.2025.100835","url":null,"abstract":"<div><div>Surface topography and mechanical properties of wound dressing significantly influence cell behavior and tissue regeneration process. Skin has unique textures, which are often overlooked in the preparation of wound dressings. Herein, we fabricated biomimetic wound dressings by transferring the surface textures of skin through electrospinning technology. Specifically, the top and bottom surface of pig skin employed as substrates for the collection of electrospinning nanofibers composed of polylactic acid and gelatin (PLLA/GL). Due to the existence of hair on the top surface of pig skin, the transferred nanofiber membrane (skin-top) exhibited scattered small pores (∼50 μm). In contrast, the transferred nanofiber membrane with aluminum foil (Al) as substrate displayed a smooth surface. Benefit from the unique surface properties of skin, the skin-based nanofiber membrane demonstrated improved roughness and enhanced air permeability. Specifically, skin-top based wound dressing showed the best performance in promoting wound healing, including enhanced epithelialization and collagen deposition.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100835"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-25DOI: 10.1016/j.colcom.2025.100833
Jin Liu , Tianle Liu , Chi Zhang , Ziyou Wang , Xinyi Zhang , Chuanchuan Hao , Dan Wang , Guohui Cheng
By focusing on mitochondria as a therapeutic target, strategies can be devised to deplete ATP levels, thereby potentially circumventing the emergence of MDR. In this study, we developed a surface-modified hyaluronic acid (HA), mitochondrial targeted hollow mesoporous silicon nanomedicine (PB@HMSN-HA) co-loaded with berberine (BBR) and paclitaxel (PTX) for enhanced colorectal cancer therapy. The modified HA can selectively bind to tumor cells that overexpress the CD44 receptor, leading to the accumulation of PB@HMSN-HA at the tumor site and improving tumor targeting efficiency. After cellular internalization, the liberated positively charged BBR, which is specifically targeted to mitochondria, induces a reduction in ATP levels. Depletion of ATP subsequently results in a reduction of drug efflux, thereby amplifying the antitumor efficacy of PTX. Therefore, this combination therapy strategy targeting mitochondria serves as an important reference for clinical oncological chemotherapy.
{"title":"A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy","authors":"Jin Liu , Tianle Liu , Chi Zhang , Ziyou Wang , Xinyi Zhang , Chuanchuan Hao , Dan Wang , Guohui Cheng","doi":"10.1016/j.colcom.2025.100833","DOIUrl":"10.1016/j.colcom.2025.100833","url":null,"abstract":"<div><div>By focusing on mitochondria as a therapeutic target, strategies can be devised to deplete ATP levels, thereby potentially circumventing the emergence of MDR. In this study, we developed a surface-modified hyaluronic acid (HA), mitochondrial targeted hollow mesoporous silicon nanomedicine (PB@HMSN-HA) co-loaded with berberine (BBR) and paclitaxel (PTX) for enhanced colorectal cancer therapy. The modified HA can selectively bind to tumor cells that overexpress the CD44 receptor, leading to the accumulation of PB@HMSN-HA at the tumor site and improving tumor targeting efficiency. After cellular internalization, the liberated positively charged BBR, which is specifically targeted to mitochondria, induces a reduction in ATP levels. Depletion of ATP subsequently results in a reduction of drug efflux, thereby amplifying the antitumor efficacy of PTX. Therefore, this combination therapy strategy targeting mitochondria serves as an important reference for clinical oncological chemotherapy.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100833"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-28DOI: 10.1016/j.colcom.2025.100832
Yinggang Liu , Zunqing Liu , Guofei Chen , Xingzhong Fang
The development of transparent hydrophobic coatings with durability is crucial required both optical transparency and hydrophobic properties for application. In this study, a series of durable, transparent and hydrophobic coatings were prepared by dispersing hydrophobic fumed silica (SiO2) in the fluorinated polysilazanes (FPSZ) matrix and then spraying the mixture onto microscope slides. The coating FPC-1 achieved excellent comprehensive performances showing a water contact angle of 125°, a transmittance of 88.9 % at 400 nm, a pencil hardness of 6H, and an adhesion class of 5B. In addition, the coating of FPC-1 could withstand chemical corrosion for 7 days and 100 cycles of abrasion without significant degradation. These coatings show has great potential for applications in transparent optical devices.
{"title":"Synthesis and characterization of enhanced hydrophobic polysilazane coatings with high transparency and durability","authors":"Yinggang Liu , Zunqing Liu , Guofei Chen , Xingzhong Fang","doi":"10.1016/j.colcom.2025.100832","DOIUrl":"10.1016/j.colcom.2025.100832","url":null,"abstract":"<div><div>The development of transparent hydrophobic coatings with durability is crucial required both optical transparency and hydrophobic properties for application. In this study, a series of durable, transparent and hydrophobic coatings were prepared by dispersing hydrophobic fumed silica (SiO<sub>2</sub>) in the fluorinated polysilazanes (FPSZ) matrix and then spraying the mixture onto microscope slides. The coating FPC-1 achieved excellent comprehensive performances showing a water contact angle of 125°, a transmittance of 88.9 % at 400 nm, a pencil hardness of 6H, and an adhesion class of 5B. In addition, the coating of FPC-1 could withstand chemical corrosion for 7 days and 100 cycles of abrasion without significant degradation. These coatings show has great potential for applications in transparent optical devices.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100832"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-03DOI: 10.1016/j.colcom.2025.100834
Maria Auriemma , Maria Isabella Maremonti , Edmondo Battista , Filippo Causa
A simulation tool to predict the morphological features and dynamics of polymeric microdroplets in a microfluidic T-junction is presented. A phase-diagram of regimes is created moving from dripping to squeezing within ranges of 10−2–10−4 and 10−1–10−3 for Reynolds and Capillary numbers, respectively. The simulations show the strong influence of the continuous phase over the droplet size, which changes two orders of magnitude -increasing from 101 to 102 μm- as the flowrate becomes higher.
The phase-diagram allows to choose the optimal fluid-flow conditions to have a precise and stable dripping production of spherical drops. Indeed, a successful down-scaling of drop size up to ∼101 μm with a drop rate production of ∼40 drops/s is obtained, with a great accordance between simulative and experimental results (error < 1 %), at high monodispersity (polydispersity index<0.05). Therefore, our tool has proved to be a powerful approach to predict and regulate polymeric microdroplet production in microfluidics.
{"title":"A CFD simulation tool for experimental prediction of inflow polymeric microdroplet formation in a T-junction configuration","authors":"Maria Auriemma , Maria Isabella Maremonti , Edmondo Battista , Filippo Causa","doi":"10.1016/j.colcom.2025.100834","DOIUrl":"10.1016/j.colcom.2025.100834","url":null,"abstract":"<div><div>A simulation tool to predict the morphological features and dynamics of polymeric microdroplets in a microfluidic T-junction is presented. A phase-diagram of regimes is created moving from dripping to squeezing within ranges of 10<sup>−2</sup>–10<sup>−4</sup> and 10<sup>−1</sup>–10<sup>−3</sup> for Reynolds and Capillary numbers, respectively. The simulations show the strong influence of the continuous phase over the droplet size, which changes two orders of magnitude -increasing from 10<sup>1</sup> to 10<sup>2</sup> μm- as the flowrate becomes higher.</div><div>The phase-diagram allows to choose the optimal fluid-flow conditions to have a precise and stable dripping production of spherical drops. Indeed, a successful down-scaling of drop size up to ∼10<sup>1</sup> μm with a drop rate production of ∼40 drops/s is obtained, with a great accordance between simulative and experimental results (error < 1 %), at high monodispersity (polydispersity index<0.05). Therefore, our tool has proved to be a powerful approach to predict and regulate polymeric microdroplet production in microfluidics.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100834"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.
{"title":"Smart self-assembled nanomedicine for ferroptotic tumor therapy","authors":"Chen Liang , Tian Zhang , Qingming Zhang , Xiaozhou Mou","doi":"10.1016/j.colcom.2025.100829","DOIUrl":"10.1016/j.colcom.2025.100829","url":null,"abstract":"<div><div>Featured by iron-dependent lipid peroxidation, ferroptosis is increasingly recognized as a prominent route for programmed tumor therapy. However, the adaptivity, complexity, and heterogeneity of tumors hamper the performance of ferroptotic tumor therapies. Recent advances in molecularly self-assembled nanomedicine show promise in rejuvenating ferroptotic tumor therapies by leveraging the principles of molecular self-assembly (MSA). This review first sketches the basis of ferroptosis and MSA. Subsequently, representative nanoplatforms are discussed to elucidate how MSA can be devised, either in vitro or in vivo, to improve the precision, efficacy, and biosafety of ferroptotic tumor therapies. Finally, considerations and future perspectives toward clinical translation of molecularly self-assembled ferroptosis nanomedicine are addressed.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100829"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study explores the stabilization mechanisms of concentrated emulsions with tunable morphology using amphiphilic polymer-grafted nanoparticles (PGNPs). We employ coarse-grained molecular simulations to investigate concentrated oil-in-water emulsions stabilized by partially hydrolyzed poly(vinyl alcohol)-grafted poly(methyl methacrylate) (PMMA) particles. Two grafting architectures were examined: hydrophilic-hydrophobic (AB-type) diblock PGNPs and reverse BA-type diblock PGNPs. Our findings reveal that AB-type diblock PGNPs tend to aggregate, leading to droplet-droplet coalescence. In contrast, BA-type diblock PGNPs disperse effectively in the water phase, stabilizing robust emulsion through a space-filling mechanism. The study further demonstrates that the stability and morphology of the emulsions can be tuned by varying the number of PGNPs. Our results suggest that BA-type diblock PGNPs are more effective in stabilizing concentrated emulsions, offering insights for the design of novel emulsifiers in industrial applications.
{"title":"Effects of grafting architecture of amphiphilic polymer-grafted nanoparticles on stabilization mechanisms of concentrated emulsions","authors":"Kojiro Suzuki , Yusei Kobayashi , Takashi Yamazaki , Toshikazu Tsuji , Noriyoshi Arai","doi":"10.1016/j.colcom.2025.100822","DOIUrl":"10.1016/j.colcom.2025.100822","url":null,"abstract":"<div><div>This study explores the stabilization mechanisms of concentrated emulsions with tunable morphology using amphiphilic polymer-grafted nanoparticles (PGNPs). We employ coarse-grained molecular simulations to investigate concentrated oil-in-water emulsions stabilized by partially hydrolyzed poly(vinyl alcohol)-grafted poly(methyl methacrylate) (PMMA) particles. Two grafting architectures were examined: hydrophilic-hydrophobic (AB-type) diblock PGNPs and reverse BA-type diblock PGNPs. Our findings reveal that AB-type diblock PGNPs tend to aggregate, leading to droplet-droplet coalescence. In contrast, BA-type diblock PGNPs disperse effectively in the water phase, stabilizing robust emulsion through a space-filling mechanism. The study further demonstrates that the stability and morphology of the emulsions can be tuned by varying the number of PGNPs. Our results suggest that BA-type diblock PGNPs are more effective in stabilizing concentrated emulsions, offering insights for the design of novel emulsifiers in industrial applications.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100822"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-02-27DOI: 10.1016/j.colcom.2025.100824
Vladimir Rosenov Koynarev , Thomas Daniel Vogelaar , Mahmoud Moqadam , Nathalie Reuter , Reidar Lund
Antimicrobial peptides (AMPs) have shown great potential against the ongoing rise of multi-drug resistant bacteria because of their high potency and effectiveness. Their clinical utility has, however, remained limited due to their severe side effects. As an exception, colistin (polymyxin E) is currently utilized as a last-resort option against severe gram-negative infections despite being cyto- and nephrotoxic. The ongoing efforts to reduce these side effects are hampered by the generally poor understanding of its mode of action and behavior in solution. A key question that has been debated is whether colistin self-assembles into micelles or remains as unimers in solution. Herein, we used synchrotron small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and molecular dynamics (MD) to show that colistin does not self-assemble in a wide range of physiologically relevant conditions. These contrasting findings, compared to previously reported results, provide important new insights into the behavior of colistin, aiding the understanding and potential improvement of this relevant AMP-based antibiotic.
{"title":"Colistin does not self-assemble at physiologically relevant conditions","authors":"Vladimir Rosenov Koynarev , Thomas Daniel Vogelaar , Mahmoud Moqadam , Nathalie Reuter , Reidar Lund","doi":"10.1016/j.colcom.2025.100824","DOIUrl":"10.1016/j.colcom.2025.100824","url":null,"abstract":"<div><div>Antimicrobial peptides (AMPs) have shown great potential against the ongoing rise of multi-drug resistant bacteria because of their high potency and effectiveness. Their clinical utility has, however, remained limited due to their severe side effects. As an exception, colistin (polymyxin E) is currently utilized as a last-resort option against severe gram-negative infections despite being cyto- and nephrotoxic. The ongoing efforts to reduce these side effects are hampered by the generally poor understanding of its mode of action and behavior in solution. A key question that has been debated is whether colistin self-assembles into micelles or remains as unimers in solution. Herein, we used synchrotron small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and molecular dynamics (MD) to show that colistin <em>does not</em> self-assemble in a wide range of physiologically relevant conditions. These contrasting findings, compared to previously reported results, provide important new insights into the behavior of colistin, aiding the understanding and potential improvement of this relevant AMP-based antibiotic.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"65 ","pages":"Article 100824"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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