Colloid and Interface Science Communications最新文献

Intraocular cancers such as retinoblastoma and uveal melanoma will induce severe vision loss or even death. Herein, a versatile nanocomposite thermogel based on hexanoyl glycol chitosan (HGC) and mesoporous polydopamine nanoparticles (MPDA NPs) was designed for potential use as an intraocular “drug depot” for the treatment of intraocular tumors. The integrated HGC-MPDA thermogel showed reversible sol-gel transition property as well as injectable and in-situ gelation abilities. The incorporated MPDA NPs endowed the thermogel with outstanding NIR laser-based photothermal conversion ability and enabled NIR light-controlled drug release. Moreover, in vitro study revealed that drug-loaded thermogel (HGC-MPDA@DOX) with the aid of 808 nm laser irradiation possessed superior anticancer effect than any single treatment via synergistic chemo-photothermal therapy. The present study demonstrated that HGC-MPDA could serve as a multifunctional platform for sustained and NIR light-responsive intravitreal drug delivery, avoiding repetitive injection, and the localized chemo-photothermal therapy provides a promising strategy against intraocular tumors.

In this paper, a new cross-linked chitosan by G1 dendrimer from melamine terminated by citric acid groups to support Cu(II) nanoparticles (CS@CA-Me-CA@Cu) was designed and prepared. Subsequently, the prepared nanocomposite was characterized using different spectroscopic, microscopic and analytical techniques such as FTIR, XRD, FESEM, TGA and EDX. The supramolecular CS@CA-Me-CA@Cu demonstrates higher thermal and chemical stability than its components. In addition, in order to investigate the catalytic performance of the CS@CA-Me-CA@Cu bio-based nanocomposite it was used, as a Lewis acidic and green heterogeneous catalyst, for the preparation of 2-aminobenzothiazole derivatives under green conditions. Also, other advantages of this new bio-based nanocomposite include easy preparation, high catalytic activity, recyclability, and reuse with a gradual decreasing in its catalytic activity.

New mixed-matrix ultrafiltration membranes (MMMs) made of polyethersulfone (PES) and microcrystalline cellulose (MCC) were created utilizing a nonsolvent induced phase separation (NIPS) approach for the remediation of bromate (BrO₃⁻) from aqueous medium. The influence of MCC integrated on the contact angle, porosity, water flux, and BrO₃⁻ adsorption performance was also examined. The addition of MCC, up to 5 wt%, resulted in a significant decline in the contact angle from 60.1° of neat PES to 43.1°, indicating an increase in membrane hydrophilicity. Moreover, MCC incorporation at 1, 3, and 5 wt% concentrations led to an enhancement in the water flux to 169, 178, and 180 L m⁻² h⁻¹, respectively, indicating the improved membrane permeability. MCC-integrated PES membranes exhibited enhanced antifouling properties, as demonstrated by the achieved high flux recovery ratio (99%) of the 5% MCC-containing membrane. Furthermore, all MCC-integrated PES membranes exhibited superior performance in the removal of bromate ions (BrO₃⁻), with rejection rates of 60.8%, 80.2%, and 92% for 1%, 3%, and 5% MCC, respectively, which was much greater than that of the virgin PES membrane.

Gold nanorods (AuNRs) have an increasing presence in biomedical research, but it remains unclear how aspect ratio (AR) influences their subcellular distribution. Here, we quantified the cellular adsorption and internalization kinetics and correlated them with the subcellular distribution of AuNRs. It is found that the distribution ratio between internalized and surface-adsorbed AuNRs decreases with increasing AR, with modest AR of 3.2 being most favorable for long-efficient delivery into cells. Long edge and blunt tip, critical to the adsorption and internalization, are simultaneously satisfied by this modest AR. Other ARs cause obvious barriers in the intermediate steps, contributing to uneven subcellular AuNR accumulation. Additionally, internalization shifts from spontaneous wrapping to clathrin-mediated ATP-dependent endocytosis with increasing AR. Inhibition of the endocytic pathways can reduce the distribution ratio, with the magnitude of effect depending on their importance to the internalization. These findings extend our knowledge of the subcellular distribution mechanisms of non-spherical nanoparticles.

Acetylenic diol surfactants, named after the carbon–carbon triple bond known as the acetylene bond, exhibit good dynamic surface tension and foam-free properties. They are widely used as wetting agents and molecular defoamers in industry and research. Although the role of the hydrophilic and hydrophobic moieties of these surfactants are well characterized, the effect of the acetylene bond on their surface activity has not yet been elucidated. To this end, herein, the chemical structure, equilibrium surface tension, dynamic surface tension, and foam properties of an alkyne free diol, SC14 diol, were analyzed and compared with those of an acetylenic diol, Surfynol 104. An increase in the rate of diffusion of the surfactant from water–air surfaces was observed when the acetylene bond existed. The performance of both diols as surfactants was discussed. The unique performance of SC14 diol surfactant enhances its potential applicability value in the field of ink and paint manufacturing.

Tantalum (Ta) and its alloys have attracted extensive attention in orthopedic field, while the underlying mechanism of abrasive debris effects on bone remains unveiled. Therefore, it is essential to explore the effects of Ta wear particle characteristics on macrophage, osteoblast and osteoclast response. In this study, spherical Ti and Ta particles with similar sizes were employed as material models to mimic wear debris. It was found that Ti or Ta particle surfaces were covered by a naturally formed oxide layer, with Ta particle surfaces possessing more hydroxyls and lower zeta potential. The in vitro results showed that Ta particles exhibited much milder modulatory effects on osteoblast, macrophage and osteoclast response than Ti particles. Moreover, the in vivo osteolytic effect of Ta particles was much weaker than that of Ti particles after the injection of these particles into the cranial sites of mice for 2 weeks.

Manufacturing lipid nanoparticles through microfluidic mixing can be approached from a Quality by Design perspective. Research involving critical process parameters seems to focus on the total flow and flow rate ratio, thus other process variables, such as dialysis, are underestimated. This study used a Design of Experiments to identify the influence of critical process parameters on particle size, polydispersity index, and zeta potential. A response surface Design of Experiments modeled the influence of: total flow (400 to 4000 μL min-1); flow rate ratio (3 to 9) and dialysis (yes/no). Results suggest that dialysis is a crucial parameter that strongly influences particle size and zeta potential and moderately affects polydispersity index. The flow rate ratio's relevance decreases when dialysis is performed. As the purification method can change the influence of other process parameters, it should be an integrated part of the microfluidic manufacturing of lipid nanoparticles instead of an extra step.

The construction of hydroxyapatite (HA) antibacterial coating on titanium surface is one of the current research hot topics. Natural antimicrobial agents can promote bone production while sterilizing. In this paper, Polypyrrole (PPy) is driven in situ by pulsed electrochemical deposition. Under the oxidation potential, the amino group of Pyrrole (Py) monomer interacts with PO₄³⁻ and Dexamethasone root ion(Dex⁻) in the electrolyte through electrostatic interaction. The phenolic hydroxyl group chitosan quaternary ammonium salt (2-hydroxypropyltrimethyl ammonium chloride chitosan, HTCC) interacts with N atom of the amino group on Py and forms hydrogen bonds to assist Py in regulating Dexamethasone (Dex) the drug. While under the reduction potential, OH⁻ is produced near the working electrode to promote the generation of HA, and finally forms the PPy@HA/Dex/HTCC composite coating. The study show that the composite coating is spherical nanoparticles with uniform distribution, and the regulation effect of PPy reduces the release rate of Ca²⁺ and Dex⁻ from the coating, making it release smoothly and slowly. The antibacterial ratio of the composite coating against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) reaches 100%, the osteoblasts and vascular endothelial cells proliferate well on the surface of the composite coating in vitro. Besides, the composite coating can induce the growth of apatite, proving that it has good bioactivity.

In this study, MgAl layered double hydroxides (Mg-Al/LDH)-decorated invasive plant (Praxelis clematidea)-derived biochar (MgAl/LDH-PBC) were prepared by the co-precipitation method. The characterization results revealed that the modified biochar surface offered more active adsorption sites, facilitating the Cr (VI) adsorption. MgAl/LDH-PBC showed an excellent adsorption capacity of 177.88 mg/g in a monolayer, with a rapid uptake equilibrium within 180 min. In addition, even after five cycles, the desorption rates remained at about 85%, and the Cr (VI) adsorption was quite stable despite the presence of a number of other ions. Moreover, MgAl/LDH-PBC bonded efficiently with Cr (VI) via electrostatic interaction, oxidation-reduction reaction, ion-exchange reaction, complexation, and co-precipitation. Based on these findings, MgAl/LDH-PBC may be used as an adsorbent for the removal of Cr (VI) from sewage and the management of invasive plant species.

The cinnamaldehyde has the enormous potential in the antibacterial fields, but the inherent volatility is the major weaknesses in practical application. Herein, a novel strategy of which to encapsulate cinnamaldehyde into Pickering emulsion was adopted. The Pickering emulsion was stabilized with particles of Sapindus mukorossi modified palygorskite (Sm-Pal), and exhibited good pH and ionic strength resistance and storage stability, even in high salt environments. More importantly, the Pickering emulsion stabilized possessed enhanced antibacterial activities, the reduction (%) of Pickering emulsion toward Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and drug resistance bacteria-extended spectra of β-lactamases producing Escherichia coli (ESBL) and methicillin-resistant Staphylococcus aureus (MRSA) were 69.8%, 99.6%, 100% and 99.8%, respectively. This strategy could inspire novel designs for functional Pickering emulsions with efficient protective effect.