Colloid and Interface Science Communications最新文献

英文中文

Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks 工程壳聚糖纳米平台用于多靶点疾病治疗的生物治疗多重递送的最新进展：前景与展望

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-10-30 DOI: 10.1016/j.colcom.2025.100861

Mohammad Ali Khorasani , Seyed Morteza Naghib , Taha Jafari , Ghasem Takdehghan

A novel cancer treatment that overcomes drug resistance, bioavailability, and systemic toxicity using nanocarrier technologies to deliver chemotherapeutic drugs and nucleic acids, is a multi-delivery strategy. In recent preclinical trials of multidrug-resistant malignancies, chitosan-based nanoparticles reduced tumors (doxorubicin (DOX) + survivin siRNA and curcumin + siRNA). Folate-chitosan-paclitaxel/miR-200c co-delivery trials have increased ovarian cancer patients' disease-free survival up to ∼5 months. Researchers have developed liposomes, polymeric nanoparticles, dendrimers, micelles, and inorganic nanoparticles to secure cargo, ensure proper release, and improve tumor targeting. The absorption of ligands and pH- or redox-responsive components in HepG2 cells has increased. Fluorescence spectroscopy and flow cytometry are applied to quantify cellular uptake and monitor intracellular drug release, while inductively coupled plasma mass spectrometry (ICP-MS) can be used for precise quantification of inorganic nanoparticle content within cells. Chitosan-based intelligent systems like TAT-C-SS-P significantly reduce IL-6 levels and tumor incidence by 80 % (p < 0.001). Despite these advances, clinical translation still struggles to obtain regulatory approval, ensure consistent results, and scale. Over 23 clinical trials using chitosan nanoparticles are underway or completed. Their initial studies reveal low toxicity and long-term medication delivery. Tailored nanomedicines that can accurately control the release of multiple drugs over time and space are essential for co-delivery systems.

利用纳米载体技术递送化疗药物和核酸，一种克服耐药性、生物利用度和全身毒性的新型癌症治疗方法是一种多重递送策略。在最近的多药耐药恶性肿瘤的临床前试验中，壳聚糖基纳米颗粒减少了肿瘤（多柔比星(DOX) +生存素siRNA和姜黄素+ siRNA）。叶酸-壳聚糖-紫杉醇/miR-200c联合递送试验将卵巢癌患者的无病生存期延长至5个月。研究人员已经开发了脂质体、聚合纳米颗粒、树突状大分子、胶束和无机纳米颗粒来保护货物，确保适当的释放，并改善肿瘤靶向性。HepG2细胞对配体和pH或氧化还原反应成分的吸收增加。荧光光谱和流式细胞术可用于定量细胞摄取和监测细胞内药物释放，而电感耦合等离子体质谱（ICP-MS）可用于精确定量细胞内无机纳米颗粒含量。基于壳聚糖的智能系统，如TAT-C-SS-P，可显著降低80%的IL-6水平和肿瘤发病率（p < 0.001）。尽管取得了这些进展，但临床翻译仍在努力获得监管部门的批准，确保一致的结果和规模。超过23个使用壳聚糖纳米颗粒的临床试验正在进行或完成。他们的初步研究显示低毒性和长期给药。定制的纳米药物可以精确地控制多种药物随时间和空间的释放，这对于共同递送系统至关重要。

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引用次数: 0

Tumor-targeted hybrid micelles enable ROS-responsive CO release and synergistic chemo–gas antitumor therapy 肿瘤靶向杂交胶束可实现ros响应的CO释放和协同化学气体抗肿瘤治疗

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-10-30 DOI: 10.1016/j.colcom.2025.100862

Zhanglong Huang , Shiwei Ding , Lili Zhong, Chenxi Liu, Xiaofei Li, Dan He

Combination therapy holds great promise for enhancing antitumor efficacy by achieving tumor-targeted and sequentially synergistic cytotoxicity. We developed a tumor-targeted hybrid micellar nanoplatform that co-delivers the chemotherapeutic agent pemetrexed (PEM) and carbon monoxide (CO) for synergistic chemo-gas therapy. PEM and Fe₃(CO)₁₂ were covalently conjugated to D-α-tocopheryl polyethylene glycol succinate (TPGS), yielding two amphiphilic prodrugs—TPGS-PEM and TPGS-CO—which were co-assembled into hybrid micelles. The presence of PEM enabled folate receptor-mediated active targeting, resulting in efficient uptake by 4T1 breast cancer cells. Intracellular esterase-catalyzed cleavage of the ester bond released PEM, which elevated reactive oxygen species (ROS) levels. The increase in ROS triggered site-specific CO release from the Fe–CO complex. This sequential mechanism enabled a cascade of tumor-selective chemotherapy and gas therapy, leading to enhanced apoptosis and reduced tumor proliferation. The hybrid micelles exhibited superior tumor suppression, reduced systemic toxicity, and prolonged survival in tumor-bearing mice.

联合治疗通过实现肿瘤靶向和顺序协同细胞毒性来增强抗肿瘤疗效。我们开发了一种肿瘤靶向的混合胶束纳米平台，该平台共同递送化疗药物培美曲塞（PEM）和一氧化碳（CO），用于协同化疗-气体治疗。PEM和Fe₃（CO）₁₂与D-α-生育酚基聚乙二醇琥珀酸酯（TPGS）共价偶联，得到两种两亲性前药TPGS-PEM和TPGS-CO，并将其共组装成杂化胶束。PEM的存在使叶酸受体介导的活性靶向，导致4T1乳腺癌细胞的有效摄取。细胞内酯酶催化的酯键裂解释放PEM，从而提高活性氧（ROS）水平。ROS的增加触发了Fe-CO络合物中特定位点的CO释放。这种顺序机制使肿瘤选择性化疗和气体治疗级联，导致细胞凋亡增强和肿瘤增殖减少。杂交胶束在荷瘤小鼠中表现出良好的肿瘤抑制作用，降低了全身毒性，延长了存活时间。

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引用次数: 0

A sugar-responsive dynamic biointerface for the regulation of cell adhesion and macrophage polarization behavior 调节细胞粘附和巨噬细胞极化行为的糖响应动态生物界面

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-10-16 DOI: 10.1016/j.colcom.2025.100860

Pengjia Yan , Wenbo He , Xin Du , Wenxiu Hou , Miao Luo , Changwei Tan , Jinling Luo , Xiaoqian Jiang , Ji Qiu , Ling Bai , Guoqing Pan

Here we report a new strategy for the functionalization of soft polyacrylamide (PAM) hydrogels with a sugar-responsive dynamic biointerface, offering a more accurate mimicry of the cellular microenvironment for cell dynamic adhesion and macrophage polarization. This dynamic platform shows the potential for recapitulating the physiological stiffness of various human tissues, enabling the modulation of cell behaviors through a natural biofeedback mechanism.

在这里，我们报道了一种具有糖响应动态生物界面的软聚丙烯酰胺（PAM）水凝胶功能化的新策略，为细胞动态粘附和巨噬细胞极化提供了更准确的细胞微环境模拟。这个动态平台显示了再现各种人体组织生理刚度的潜力，使细胞行为能够通过自然生物反馈机制进行调节。

引用次数: 0

Corrigendum to ‘Photo-Sono activated fluorine-doped titanium-based bone implants for rapid osteosarcoma eradication and bacterial infection elimination’ [Colloid and Interface Science Communications 60 (2024) 100783/COLCOM-D-23-00244] “用于快速根除骨肉瘤和消除细菌感染的光声激活氟掺杂钛基骨植入物”的更正[胶体和界面科学通讯60 (2024)100783/COLCOM-D-23-00244]

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-10-14 DOI: 10.1016/j.colcom.2025.100859

Guannan Zhang , Hailiang Zhang , Rong Li , Ying Lu , Qinying Shi , Xin Yang , Jianbo Song

引用次数: 0

Green preparation of nanoemulsion of Cinnamomum burmanni (Nees et T.Nees) blume essential oil loaded with cinnamaldehyde and evaluation of its antibacterial, anti-inflammatory, antioxidant and wound healing activities 载肉桂醛的肉桂蓝精油纳米乳的制备及其抗菌、抗炎、抗氧化和伤口愈合活性的评价

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-09-24 DOI: 10.1016/j.colcom.2025.100858

Wei Liu , Yue Zhu , Teng Chen , Zuhua Wang , Shuang Yan , Yuxin Pang

Cinnamomum burmanni (Nees & T. Nees) Blume oil (CBO) and cinnamaldehyde (CA) are natural compounds with promising wound healing. However, their application is limited by volatility. In this study, a tea saponin (TS)-stabilized nanoemulsion (CBO-TS NEs) was developed under conditions: 1 % CBO, 3 mg/mL TS, and 2 min of ultrasonication at 260 W. The CBO-TS NEs exhibited a particle size of 140.27 ± 3.11 nm and good stability under various conditions. After loading CA (10 μL) into CBO-TS NEs, the particle size becomes 156 ± 2.66 nm, and the transdermal delivery efficiency of CA was enhanced. The CACBO-TS NEs demonstrated notable anti-inflammatory and antioxidant activities, promoted the migration of L929 cells, and exhibited broad-spectrum antimicrobial efficacy. In vivo experimental results indicated that the CACBO-TS NEs achieved superior wound healing outcomes, underscoring a synergistic therapeutic effect between CBO and CA, highlighting the considerable application potential of CACBO-TS NEs for wound healing.

肉桂油（CBO）和肉桂醛（CA）是具有良好创面愈合作用的天然化合物。然而，它们的应用受到波动性的限制。以茶皂素（TS）稳定纳米乳（CBO-TS NEs）为原料，在1% CBO、3 mg/mL TS、260 W超声作用2 min的条件下制备。CBO-TS NEs的粒径为140.27±3.11 nm，在各种条件下均具有良好的稳定性。在CBO-TS NEs中加入CA （10 μL）后，CA的粒径变为156±2.66 nm， CA的透皮递送效率提高。caco - ts NEs具有显著的抗炎和抗氧化活性，促进L929细胞的迁移，并具有广谱的抗菌作用。体内实验结果表明，CBO- ts NEs具有较好的创面愈合效果，表明CBO与CA具有协同治疗作用，CBO- ts NEs在创面愈合方面具有较大的应用潜力。

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引用次数: 0

Synthesis and characterization of structurally variable bola type crown ether-ferrocene surfactant vesicles 结构可变波拉型冠醚-二茂铁表面活性剂囊泡的合成与表征

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-09-19 DOI: 10.1016/j.colcom.2025.100857

Wei Li, Yuji Jinbo, Tatsuro Kijima

Bola-type ferrocene surfactants with terminal 18-crown-6-ether groups were synthesized. Despite showing no improvement in activity over the monosubstituted analog, they exhibited a very low critical aggregation concentration (0.06 mM). Glucose encapsulation and SAXS confirmed vesicle formation with an internal aqueous phase, enabling controlled release via potassium ion complexation.

合成了末端具有18冠-6醚基团的bola型二茂铁表面活性剂。尽管与单取代类似物相比，活性没有改善，但它们表现出非常低的临界聚集浓度（0.06 mM）。葡萄糖包封和SAXS证实了内部水相的囊泡形成，通过钾离子络合控制释放。

引用次数: 0

Applications of elastic and conductive hydrogels in myocardial infarction repair 弹性和导电水凝胶在心肌梗死修复中的应用

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-09-15 DOI: 10.1016/j.colcom.2025.100856

Haien Guan, Yuehan Zhang

Myocardial infarction (MI) is one of the leading causes of death worldwide, posing a serious threat to global human health. The heart failure that often follows MI remains a major contributor to mortality. Therefore, the development of more effective treatment approaches or intervention strategies aimed at improving patients' quality of life is of great clinical significance. The emergence and advancement of cardiac tissue engineering have opened new avenues and have demonstrated promising results in practical applications. Among various biomaterials, elastic and conductive hydrogels (ECHs) have attracted extensive attention due to their excellent biocompatibility, tunable elasticity, and the potential for electrical integration with human myocardium. By virtue of their unique properties, ECHs synergize with functional cells, bioactive molecules, and therapeutic agents to markedly improve outcomes in MI repair, effectively serving as a valuable adjunct to these therapies. Rooted in the practical needs of MI therapy, this review systematically discusses the design principles of ECHs, strategies for enhancing their mechanical and electrical properties, and their synergistic applications with therapeutic cells and bioactive molecules. It further outlines recent advances and persistent challenges, offering theoretical insights and strategic directions for future innovation and clinical translation.

心肌梗死（MI）是世界范围内导致死亡的主要原因之一，对全球人类健康构成严重威胁。心肌梗死后的心力衰竭仍然是死亡率的主要原因。因此，开发更有效的治疗方法或干预策略以提高患者的生活质量具有重要的临床意义。心脏组织工程的出现和发展开辟了新的途径，并在实际应用中显示出良好的结果。在各种生物材料中，弹性和导电水凝胶（ECHs）因其优异的生物相容性、可调节的弹性以及与人体心肌电整合的潜力而受到广泛关注。由于其独特的特性，ECHs与功能细胞、生物活性分子和治疗剂协同作用，显著改善心肌梗死修复的结果，有效地作为这些治疗的有价值的辅助手段。基于心肌梗死治疗的实际需要，本文系统地讨论了ECHs的设计原则，增强其机械和电学性能的策略，以及它们与治疗细胞和生物活性分子的协同应用。它进一步概述了最近的进展和持续的挑战，为未来的创新和临床翻译提供了理论见解和战略方向。

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引用次数: 0

Fabrication of antifouling coatings through 4-benzoylbenzoic acid-mediated dextran grafting 4-苯甲酰苯甲酸介导右旋糖酐接枝制备防污涂料

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-09-04 DOI: 10.1016/j.colcom.2025.100855

Shuhou Yang , Jiacheng Lei , Shuxiang Zhang , Yizhou Xu , Dongdong Tong , Qiang Wei , Changsheng Zhao

Antifouling coatings based on natural polymers demonstrate significant advantages in biocompatibility over traditional chemical coatings, showing broad application prospects for biomedical device surface modifications. In this work, a hydrogel coating was fabricated by grafting 4-benzoylbenzoic acid onto dextran to mediate its embedding into the substrate surface, thereby immobilizing the hydroxyl groups of dextran on the substrate to form a dense hydrophilic layer. We systematically characterized the protein adsorption resistance and cell adhesion resistance of this coating strategy, and utilized these properties to achieve tumor malignancy screening of cancer cells. The coating with the most stable antifouling performance (benzophenone-dextran, 8.3–11.6 % grafting rate) was subsequently applied to PES membrane surfaces, demonstrating excellent anticoagulant properties and hemocompatibility.

天然高分子防污涂料在生物相容性方面优于传统化学涂料，在生物医学器件表面改性方面具有广阔的应用前景。本研究通过将4-苯甲酰苯甲酸接枝到右旋糖酐上，介导其在底物表面的嵌入，从而将右旋糖酐的羟基固定在底物上，形成致密的亲水层。我们系统地表征了该涂层策略的蛋白质吸附抗性和细胞粘附抗性，并利用这些特性实现了癌细胞的肿瘤恶性筛选。将具有最稳定防污性能的涂层（二苯甲酮-葡聚糖，接枝率8.3 - 11.6%）应用于PES膜表面，表现出优异的抗凝血性能和血液相容性。

引用次数: 0

Mn2+-coordinated hyaluronic acid modified nanoparticles for phloretin delivery: Breast cancer treatment Mn2+配位透明质酸修饰纳米颗粒用于输送根皮素：乳腺癌治疗

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-08-05 DOI: 10.1016/j.colcom.2025.100854

Shouguang Wang , Xiaofei Zhang , Dunmin Zhuang , Lina Dong , Bo Li

Objective

Breast cancer remains a global health challenge due to limitations of conventional therapies, such as drug resistance and systemic toxicity. This study aimed to develop a novel synergistic chemo-immunotherapy platform by constructing Mn²⁺-coordinated oxidized hyaluronic acid (OHA)-based nanoparticles co-loaded with phloretin (PHL) (OHA@Lys/PHL Mn²⁺).

Methods

A nanosystem was engineered using oxidized hyaluronic acid (OHA) modified with lysine (Lys) to co-encapsulate PHL and Mn²⁺ ions. The anti-tumor efficacy was evaluated in vitro (4 T-1 breast cancer cells) and in vivo (4 T-1 tumor-bearing mice), including assessments of proliferation inhibition, apoptosis induction, reactive oxygen species (ROS) accumulation, DNA damage, cGAS-STING pathway activation, and dendritic cell (DC) maturation. Combination therapy with cisplatin (CDDP) was also investigated.

Results

OHA@Lys/PHL Mn²⁺ achieved 80.3 % cell viability inhibition on 4 T-1 cells. Combined with CDDP, it further suppressed proliferation, induced apoptosis, and enhanced ROS accumulation. Mechanistically, the nanosystem induced DNA double-strand damage and activated the cGAS-STING pathway. In vivo, OHA@Lys/PHL Mn²⁺ monotherapy showed significant tumor inhibition (46.4 %, p < 0.001). Combination with CDDP achieved near-complete tumor suppression (86.7 % inhibition) and reduced lung metastasis. The in vivo mechanism results indicated that nanosystem triggered DNA damage, activated cGAS-STING signaling, and significantly promoted DC maturation (48.5 % vs. 28.2 % in controls).

Conclusion

This strategy offers a promising and clinically translatable approach for advanced breast cancer treatment.

由于传统治疗方法的局限性，如耐药和全身毒性，乳腺癌仍然是一个全球性的健康挑战。本研究旨在通过构建氧化透明质酸（OHA）纳米粒子（OHA@Lys/PHL Mn2+）与根皮素（PHL）共载，开发一种新的协同化学免疫治疗平台。方法采用赖氨酸修饰的氧化透明质酸（OHA）包封PHL和Mn2+离子，构建纳米体系。在体外（4只T-1乳腺癌细胞）和体内（4只T-1荷瘤小鼠）评估其抗肿瘤效果，包括增殖抑制、诱导凋亡、活性氧（ROS）积累、DNA损伤、cGAS-STING通路激活和树突状细胞（DC）成熟。与顺铂（CDDP）联合治疗也进行了研究。ResultsOHA@Lys/PHL Mn2+对4个T-1细胞的细胞活力抑制率达到80.3%。与CDDP联合，进一步抑制细胞增殖，诱导细胞凋亡，增强ROS积累。在机制上，纳米系统诱导DNA双链损伤并激活cGAS-STING通路。在体内，OHA@Lys/PHL Mn2+单药治疗显示出显著的肿瘤抑制作用(46.4%,p <；0.001)。CDDP联合治疗达到了几乎完全的肿瘤抑制（抑制率为86.7%），并减少了肺转移。体内机制结果表明，纳米系统触发DNA损伤，激活cGAS-STING信号，显著促进DC成熟（对照组为48.5%比28.2%）。结论该策略为晚期乳腺癌的治疗提供了一种有前景的、可临床推广的方法。

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引用次数: 0

Denaturation and graphitization of albumin molecules induced by mechanical shear stress via in-situ point contact 原位点接触机械剪切应力诱导白蛋白分子的变性和石墨化

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications

Pub Date : 2025-07-28 DOI: 10.1016/j.colcom.2025.100853

Jiachen Chen, Heng Liu, Xiangdong Tian, Yu Yan

Many well functioned explants have shown that a gaphitized tribofilm formed on the bearing surfaces providing excellent lubrication effects, greatly improves the longevity and service safety of the joint prosthesis. Tribofilms are generally believed to be generated from protein molecules in the pseudo-synovial fluid. In this study, a modified atomic force microscopy with an alumina microsphere tip was used to articulate against low-carbon wrought CoCrMo alloy pins in protein solution. We successfully studied the process of tribofilm formation in-situ, with the results demonstrating that a critical compressive stress (>136 MPa) was required for tribofilm formation. Increasing compressive stress reduced tribofilm thickness but expanded its area and increased its modulus. In addition, with prolonged friction, the proteins gradually shifted toward graphitization. This in-situ study revealed that tribofilm growth in the articular prostheses is manifested as the expansion of the coverage area, rather than the continuous increase of thickness.

许多功能良好的外植体研究表明，在关节假体的承载表面形成的石墨化摩擦膜具有良好的润滑效果，大大提高了关节假体的使用寿命和使用安全性。一般认为摩擦膜是由伪滑液中的蛋白质分子产生的。在这项研究中，使用了一种带有氧化铝微球尖端的改进原子力显微镜，在蛋白质溶液中对低碳变形的CoCrMo合金引脚进行了清晰的表达。我们成功地在现场研究了摩擦膜的形成过程，结果表明，摩擦膜的形成需要临界压应力（>136 MPa）。增大压应力可减小摩擦膜厚度，扩大摩擦膜面积，增大摩擦膜模量。此外，随着摩擦时间的延长，蛋白质逐渐转向石墨化。本原位研究表明，关节假体中摩擦膜的生长表现为覆盖面积的扩大，而不是厚度的持续增加。

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