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IEEE Nuclear Science Symposium Conference Record, 2005最新文献

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Study of light output and response function of liquid organic scintillator for high-energy neutron spectrometry 高能中子光谱分析中液体有机闪烁体的光输出和响应函数研究
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596555
D. Satoh, T. Sato, A. Endo, N. Matsufuji, S. Sato, M. Takada, K. Ishibashi
In order to investigate the relationship between kinetic energy of charged particles and light output of liquid organic scintillator, response functions for proton, deuteron, triton, /sup 3/He nucleus and alpha particle have been measured at heavy-ion medical accelerator in Chiba (HIMAC) of National Institute of Radiological Sciences (NIRS). The charged particles were generated by 400 MeV/u C ion bombardment with a thick graphite target. Kinetic energies were determined by time-of-flight (TOF) technique. Energy loss during their flight was calculated by PHITS code and taken into account at energy-correction. Light output for proton was also measured using mono-energy proton beam of 100 and 160 MeV supplied by accelerator. Kinetic energy of proton beam was changed by inserting Al plates onto beam axis as an energy absorber. The experimental results gave a new database of light output.
为了研究带电粒子的动能与液体有机闪烁体光输出的关系,在国立放射科学研究所(NIRS)千叶重离子医用加速器上测量了质子、氘核、triton、/sup 3/He核和α粒子的响应函数。用400 MeV/u的碳离子轰击厚石墨靶产生带电粒子。动能由飞行时间(TOF)技术测定。飞行过程中的能量损失由PHITS代码计算,并在能量校正时考虑。利用加速器提供的100 MeV和160 MeV单能质子束,测量了质子的光输出。通过在质子束轴上插入铝板作为能量吸收体,改变了质子束的动能。实验结果给出了一个新的光输出数据库。
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引用次数: 1
Exact ROI image reconstruction with perturbed source trajectories in C-arm CT 基于干扰源轨迹的c臂CT精确感兴趣图像重建
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596712
D. Xia, E. Sidky, Lifeng Yu, Y. Zou, Xiaochuan Pan
In C-arm CT, the actual trajectory executed by the X-ray source may deviate from the designed scan due to mechanical error. Without taking into account this deviation, artifacts will appear in the reconstructed image. In this work, we propose to use the recently developed backprojection filtration (BPF) algorithm, which can accommodate general trajectories, to incorporate the deviation of the source trajectory. The preliminary studies demonstrate that this algorithm provides the exact image reconstruction in the case that the deviation of the source trajectory from the ideal trajectory can be measured.
在c臂CT中,由于机械误差,x射线源执行的实际轨迹可能会偏离设计的扫描。如果不考虑这种偏差,重建图像中就会出现伪影。在这项工作中,我们建议使用最近开发的反向投影滤波(BPF)算法,该算法可以容纳一般轨迹,以合并源轨迹的偏差。初步研究表明,该算法在能测量到源轨迹与理想轨迹偏差的情况下,能提供精确的图像重建。
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引用次数: 4
Influence of sensor arrangements and scintillator crystal properties on the 3D precision of monolithic scintillation detectors in PET 传感器布置和闪烁体晶体性质对PET单片闪烁探测器三维精度的影响
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596966
P. Ojala, A. Bousselham, L. Eriksson, A. Brahme, C. Bohm
This paper reports the characterization and comparison of different sensor configurations for monolithic scintillation crystals via the calculation of a figure of a merit based on statistical (Fischer) information. The optimal precision of maximum likelihood determinations of interaction positions, i.e. where annihilation photons are absorbed in a monolithic (LSO) crystal, is approximated throughout a crystal block via Fischer information (related to the width of the maximum likelihood distribution) evaluated at a grid of points. Realistic positions and thus realistic distributions of points of interaction are estimated by applying a maximum likelihood algorithm to Monte Carlo data. The algorithm was based on pattern recognition using a Monte Carlo generated lookup table and the least square method. The precision of this method is compared with the optimal (Cramer-Rao) limit for selected points
本文通过计算基于统计(菲舍尔)信息的值,报道了单片闪烁晶体的不同传感器配置的特性和比较。相互作用位置的最大似然确定的最佳精度,即湮灭光子在单片(LSO)晶体中被吸收的位置,通过在点网格上评估的Fischer信息(与最大似然分布的宽度相关)在整个晶体块中近似。通过对蒙特卡罗数据应用最大似然算法来估计相互作用点的实际位置和实际分布。该算法基于模式识别,采用蒙特卡罗生成查找表和最小二乘法。将该方法的精度与所选点的最优(Cramer-Rao)极限进行了比较
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引用次数: 4
ROI reconstruction of motion-contaminated data with a backprojection filtration algorithm 用反投影滤波算法重建运动污染数据的ROI
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596786
M. King, Lifeng Yu, D. Xia, Xiaochuan Pan, M. Giger
In order to evaluate the potential of using the backprojection filtration (BPF) algorithm for reconstructing images from motion-contaminated data, simulation studies were conducted with three virtual phantoms. The first was a uniform elliptical phantom, which underwent rotational motion during half of its temporal cycle. The second was a normal-sized modified FORBILD phantom with a dynamic insert undergoing contractile motion during 65% of its temporal cycle. This phantom was expanded to form a third phantom, whose portions extended beyond the field-of-view (FOV). For the elliptical phantom, the BPF algorithm was able to obtain an exact reconstruction of a region-of-interest (ROI) covering a portion of the ellipse, whereas the fanbeam filtered backprojection (FFBP) algorithm could not. For the normal-sized phantom, nine full-scan data sets were acquired with percents of motion-contaminated data PMCDs ranging from 17.5% to 100%. For each data set, the mean absolute difference MAD, root mean square error RMS, and correlation CORR metrics were used to assess the differences between a defined ROI reconstructed from motion-contaminated data from the same ROI reconstructed from motion-free data. The BPF algorithm using a reduced-scan interval was able to produce better MAD, RMS, and CORR metrics than both FFBP and BPF algorithms using the same short-scan interval over all PMCDs. For the expanded phantom, the presence of truncations in the data sets did not affect the overall trends of the three metrics in BPF reconstructions of eight data sets with PMCDs ranging from 15% to 100%.
为了评估使用反向投影滤波(BPF)算法从运动污染数据中重建图像的潜力,使用三个虚拟幻影进行了仿真研究。第一个是均匀的椭圆幻像,它在一半的时间周期内进行旋转运动。第二个是一个正常大小的改良FORBILD假体,在其65%的时间周期内进行动态插入运动。这个幻像被扩展成第三个幻像,其部分延伸到视野之外。对于椭圆幻影,BPF算法能够获得覆盖部分椭圆的感兴趣区域(ROI)的精确重建,而扇束滤波反投影(FFBP)算法则不能。对于正常大小的幻影,获得了9个全扫描数据集,运动污染数据pmcd的百分比从17.5%到100%不等。对于每个数据集,使用平均绝对差MAD、均方根误差RMS和相关CORR指标来评估从运动污染数据重建的定义ROI与从无运动数据重建的相同ROI之间的差异。使用缩短扫描间隔的BPF算法比使用相同短扫描间隔的FFBP和BPF算法能够在所有pmcd上产生更好的MAD、RMS和CORR指标。对于扩展幻影,数据集中截断的存在并不影响pmcd范围为15%至100%的8个数据集的BPF重建中三个指标的总体趋势。
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引用次数: 0
Hydrogenated amorphous silicon sensors based on thin film on ASIC technology 基于ASIC技术的氢化非晶硅薄膜传感器
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596579
M. Despeisse, D. Moraes, G. Anelli, P. Jarron, J. Kapłon, R. Rusack, S. Saramad, N. Wyrsch
The performance and limitations of a novel detector technology based on the deposition of a thin-film sensor on top of processed integrated circuits have been studied. Hydrogenated amorphous silicon (a-Si:H) films have been deposited on top of CMOS circuits developed for these studies and the resulting "thin-film on ASIC" (TFA) detectors are presented. The leakage current of the a-Si:H sensor at high reverse biases turns out to be an important parameter limiting the performance of a TFA detector. Its detailed study and the pixel segmentation of the detector are presented. High internal electric fields (in the order of 10/sup 4/-10/sup 5/ V/cm) can be built in the a-Si:H sensor and overcome the low mobility of electrons and holes in a-Si:H. Signal induction by generated carrier motion and speed in the a-Si:H sensor have been studied with a 660 nm pulsed laser on a TFA detector based on an ASIC integrating 5 ns peaking time pre-amplifiers. The measurement set-up also permits to study the depletion of the sensor and results are presented. Finally, direct detection of 5.9 keV X-rays with TFA detectors based on an ASIC integrating low noise pre-amplifiers (27 e/sup -/ r.m.s.) are shown.
研究了一种基于在加工集成电路上沉积薄膜传感器的新型探测器技术的性能和局限性。氢化非晶硅(a-Si:H)薄膜沉积在为这些研究开发的CMOS电路上,并提出了由此产生的“ASIC上的薄膜”(TFA)探测器。高反向偏置下a- si:H传感器的漏电流是限制TFA检测器性能的一个重要参数。对其进行了详细的研究,并对探测器进行了像素分割。高内部电场(10/sup 4/-10/sup 5/ V/cm)可以在a-Si:H传感器中建立,并克服了a-Si:H中电子和空穴的低迁移率。利用660nm脉冲激光在集成5ns峰值时间前置放大器的ASIC TFA探测器上研究了a- si:H传感器中产生的载流子运动和速度对信号的感应。测量装置还允许研究传感器的损耗,并给出了结果。最后,展示了基于集成低噪声前置放大器(27 e/sup -/ r.m.s)的ASIC的TFA探测器对5.9 keV x射线的直接探测。
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引用次数: 7
A rebinning-type backprojection-filtration algorithm for region of interest reconstruction in fan-beam CT with improved noise properties 一种改进噪声特性的扇形波束CT感兴趣区域重建反投影滤波算法
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596893
Lifeng Yu, D. Xia, Y. Zou, E. Sidky, Xiaochuan Pan, C. Pelizzari
We propose an alternative backprojection-filtration(BPF)-based reconstruction algorithm for fan-beam CT, which reconstructs images by first converting the fan-beam data to fan-parallel-beam data and then using a modified parallel-beam BPF algorithm to obtain the reconstruction. This proposed algorithm retains the properties of the original fan-beam BPF algorithm in that it can reconstruct exact region of interest (ROI) images from truncated data and/or super-short-scan data. The major advantage of this algorithm is its improved noise properties because of the elimination of the spatially-variant weighting factor. In addition, the proposed algorithm is computationally more efficient
本文提出了一种基于反投影滤波(BPF)的扇形波束CT重建算法,该算法首先将扇形波束数据转换为扇形平行波束数据,然后使用改进的平行波束BPF算法进行重建。该算法保留了原扇形波束BPF算法的特性,可以从截断的数据和/或超短扫描数据中重建精确的感兴趣区域(ROI)图像。该算法的主要优点是由于消除了空间变化的加权因子而改善了噪声特性。此外,该算法的计算效率更高
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引用次数: 0
Continuous bed motion data processing for a resolution LSO PET/CT scanner 用于分辨率LSO PET/CT扫描仪的连续床运动数据处理
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596735
Z. Burbar, C. Michel, D. Towsend, B. Jakoby, M. Sibomana, F. Kehren, S. Tolbert, J. Reed, K. Hubner, M. Abidi
Continuous whole-body PET scanning, continuous bed motion (CBM) acquisition has a number of advantages over the traditional step-and-shoot (SS) mode. Strengths of CBM include a uniform axial signal-to-noise ratio, continuous sampling in the axial direction that reduces resolution artifacts, reduction of noise from detector normalization, and reduction of sensitivity to small patient movements. This work highlights the acquisition and data handling methodology that was implemented for a series of phantoms and over 40 patient studies acquired on a high resolution, 16-slice LSO combined PET/CT scanner (CPS Innovations, Knoxville, TN). CBM data were acquired in 32-bit listmode with the bed moving at a constant speed of typically 0.6 mm/s to match the acquisition time per plane of the SS mode. CBM data were processed using the novel, virtual scanner concept that can be applied to a scanner of any axial length. For the high resolution scanner, the LSO PET detectors are arranged in a truncated spherical geometry and therefore normalization and geometrical corrections are applied on an event-by-event basis during histogramming of the 32-bit listmode data. Scatter correction is calculated on the entire image volume, in contrast to the SS mode where scatter is estimated for each bed position. The final 3D data set was reconstructed using ordinary Poisson OSEM3D. This paper will present results from phantom studies and compare clinical patient scans acquired in both SS and CBM modes
连续全身PET扫描,连续床上运动(CBM)采集与传统的步进射击(SS)模式相比具有许多优点。CBM的优点包括均匀的轴向信噪比,在轴向连续采样,减少分辨率伪影,减少检测器归一化产生的噪声,以及降低对患者微小运动的敏感性。这项工作强调了在高分辨率16层LSO组合PET/CT扫描仪(CPS Innovations, Knoxville, TN)上对一系列幻影和40多例患者研究实施的采集和数据处理方法。CBM数据是在32位的listmode下获取的,床层以通常为0.6 mm/s的恒定速度移动,以匹配SS模式的每平面采集时间。CBM数据的处理使用新颖的虚拟扫描仪概念,可以应用于任何轴向长度的扫描仪。对于高分辨率扫描仪,LSO PET探测器被安排在截断的球形几何结构中,因此在32位列表模式数据的直方图绘制过程中,标准化和几何校正是基于事件的。散射校正是在整个图像体积上计算的,而SS模式是在每个床的位置估计散射。使用普通泊松OSEM3D重建最终的三维数据集。本文将介绍幻影研究的结果,并比较在SS和CBM模式下获得的临床患者扫描
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引用次数: 17
High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: the role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout 用于放射性核素功能分子成像的高分辨率和高灵敏度探测器:闪烁体像素大小、光电探测器阳极间距、准直技术和读数的作用
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596919
F. Garibaldi, R. Accorsi, M. Cinti, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Giuliani, M. Gricia, R. Lanza, S. Meo, M. Lucentini, S. Majewski, R. Pani, R. Pellegrini, F. Santavenere, B. M. W. Tsui
Good spatial resolution and high sensitivity are required for detectors to be used for most of the bio-medical research and application (small animal imaging, detection of small tumors). In this paper we report on parameter optimization of single photon gamma rays detectors. Simulations and measurements were performed for designing and building detectors for early detection of small tumors in breast and in small animal imaging. Critical parameters are: contrast and signal to noise ratio (SNR). Intrinsic performances (spatial resolution, pixel identification etc.) were optimized first. Arrays of scintillators (NaI(Tl)) of different pixel pitch (down to the present technological limits for NaI(Tl) arrays fabrication (pitch of 2times2 mm2, 1.5times1.5 mm2 and 1.2times1.2 mm2 )) were coupled to arrays of PSPMTs with two anode readout element dimensions (6times6 mm2 and 3times3 mm2). Detectors having field of view of 100times100 mm2 and 150times200 mm2 were designed and built. An electronics system for reading out all the anode pad signals has been designed and constructed. Finally the collimation technique was considered. The limits of the coded aperture option have been studied. Preliminary results of these studies are presented
大多数生物医学研究和应用(小动物成像、小肿瘤检测)都要求探测器具有良好的空间分辨率和高灵敏度。本文报道了单光子伽马射线探测器的参数优化。模拟和测量进行了设计和构建探测器早期检测乳腺小肿瘤和小动物成像。关键参数是:对比度和信噪比(SNR)。首先对其内在性能(空间分辨率、像素识别等)进行优化。不同像素间距的闪烁体(NaI(Tl))阵列(降低到目前NaI(Tl)阵列制造的技术极限(间距为2times2 mm2, 1.5times1.5 mm2和1.2times1.2 mm2))与具有两个阳极读出元件尺寸(6times6 mm2和3times3 mm2)的pspmt阵列耦合。设计并制造了视场为100 × 100 mm2和150 × 200 mm2的探测器。设计并构建了一个读取所有阳极衬垫信号的电子系统。最后考虑了准直技术。研究了编码孔径选择的局限性。本文给出了这些研究的初步结果
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引用次数: 1
Reconstruction algorithm for wide cone beam helical CT 宽锥束螺旋CT重建算法
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596789
A. Zamyatin, K. Taguchi, M. Silver
In practice cone beam CT reconstruction is often done using the approximate Feldkamp-type algorithms because of their flexibility and simplicity; however, when it comes to a 64- and higher detector row CT, they produce cone beam artifacts, and for 256+ detector-row CT image quality becomes unacceptable. The exact algorithms, on the other hand, produce artifact-free images but are much more computationally demanding and not very flexible in controlling noise/resolution trade-off. We propose a cone beam algorithm that can be easily adjusted depending on the cone angle. We tested it on 64-slice real data and 320-slice simulated data. For 64-slice CT it outperforms helical Feldkamp in both image quality and volume reconstruction speed; using the same redundancy weighting it reduces the cone beam artifact and improves noise uniformity. Because weighting is done after the convolution step, we can use the n-PI Tam-Danielson window, an exact cone beam weighting. We show that the weighting is more important than the filtering direction for image quality. The proposed method has good image quality without rebinning to tangential filtering lines. In evaluation we compare the proposed algorithm to helical Feldkamp and the 1-PI and 3-PI Katsevich algorithms.
在实践中,锥形束CT重建通常使用近似feldkamp型算法,因为它们的灵活性和简单性;然而,当涉及到64排及更高的检测器行CT时,它们会产生锥束伪影,并且对于256排以上的检测器行CT图像质量变得不可接受。另一方面,精确的算法产生无伪影的图像,但计算要求更高,并且在控制噪声/分辨率权衡方面不是很灵活。我们提出了一种可以根据锥角轻松调整的锥光束算法。我们在64层真实数据和320层模拟数据上进行了测试。对于64层CT,它在图像质量和体积重建速度上都优于螺旋Feldkamp;采用相同的冗余加权减少了锥波束伪影,提高了噪声均匀性。因为加权是在卷积步骤之后完成的,我们可以使用n-PI Tam-Danielson窗口,一个精确的锥束加权。结果表明,对于图像质量,加权比滤波方向更重要。该方法具有良好的图像质量,不需要对切向滤波线进行重跳。在评估中,我们将所提出的算法与螺旋Feldkamp和1-PI和3-PI Katsevich算法进行了比较。
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引用次数: 1
Backprojection-filtration reconstruction for helical cone-beam CT with curved detectors 弯曲探测器螺旋锥束CT的反投影滤波重建
Pub Date : 2005-12-01 DOI: 10.1109/NSSMIC.2005.1596795
Nianming Zuo, D. Xia, E. Sidky, Lifeng Yu, Y. Zou, Xiaochuan Pan, T. Jiang
Helical CT scanners with multi-row detectors have gained wide popularity in clinics. With increasing interest in extending the number of detector rows, the cone angle must be accounted for in image reconstruction algorithms. As the cone angle increases, artifacts in reconstructed images caused by approximate algorithms, such as the widely used FDK-based algorithms, become more of a factor that degrades the image quality. Recently, a novel reconstruction algorithm for helical cone-beam CT (CB-CT) has been proposed, which is referred to as the backprojection-filtration algorithm. This algorithm requires theoretically minimum data to reconstruct a volume image. The original BPF algorithm was presented by assuming a flat-panel detector. However, most current multi-row detectors employed in clinic CT scanners are curved detectors. In this work, we modify the backprojection-filtration (BPF) algorithm to allow for reconstruction from data collected with a curved detector. We perform simulation studies using the Shepp-Logan phantom to evaluate the modified BPF algorithm.
螺旋CT多排检波器在临床上得到了广泛的应用。随着人们对扩展检测器行数越来越感兴趣,在图像重建算法中必须考虑到锥角。随着锥角的增大,近似算法(如广泛使用的基于fdk的算法)在重构图像中产生的伪影越来越多地成为降低图像质量的因素。近年来,提出了一种新的螺旋锥束CT (CB-CT)重建算法,即反投影滤波算法。该算法理论上需要最少的数据来重建一个体图像。最初的BPF算法是在假设平板检测器的情况下提出的。然而,目前临床CT扫描仪中使用的多行探测器大多是弯曲探测器。在这项工作中,我们修改了反向投影滤波(BPF)算法,以允许从弯曲检测器收集的数据进行重建。我们使用Shepp-Logan幻影进行仿真研究,以评估改进的BPF算法。
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引用次数: 0
期刊
IEEE Nuclear Science Symposium Conference Record, 2005
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