首页 > 最新文献

Contemporary Clinical Dentistry最新文献

英文 中文
Space Closure with Different Appointment Intervals: A Split-mouth Randomized Controlled Trial. 不同预约时间间隔的空间封闭:分口随机对照试验。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_617_21
Hend Salah ElSayed, Amr Ragab El-Beialy, Juan Martin Palomo, Yehya Ahmad Mostafa

Background: Canine retraction has been successful with various force systems and retraction techniques. The appointment interval for force reactivation in canine retraction along the archwire is 4-8 weeks.

Aims: The aim was to evaluate the effect of different reactivation intervals on the rate of space closure.

Settings and design: This split-mouth randomized clinical trial recruited 38 patients indicated for the first premolar extraction.

Methods: Monthly digital models were acquired for 6 months. The first premolars were extracted, and temporary anchorage devices were placed for maximum anchorage control. The canines were retracted using elastomeric chains which were replaced every 2, 4, 6, or 8 weeks. The monthly rate of canine retraction was measured. The time to space closure was calculated. The secondary outcome was the mesial drift of the first molars.

Statistical analysis: The Kaplan-Meier survival analysis and the Friedman test evaluated and compared the groups.

Results: There was no significant difference between the monthly canine retraction rate or the first molar mesial drift between the groups. The mean time to space closure was 5.74 months in the 2-week reactivation group, which was statistically less than the other groups.

Conclusions: The 2-week reactivation interval may reduce time to space closure. Direct anchorage control with miniscrews limited anchorage loss significantly.

背景:使用不同的力量系统和牵引技术已经成功地牵引了犬齿。目的:该研究旨在评估不同重新激活间隔对间隙关闭率的影响:这项分口随机临床试验招募了38名第一前磨牙拔除患者:方法:每月采集数字模型,为期 6 个月。第一前磨牙拔除后,放置临时锚定装置以实现最大程度的锚定控制。使用弹性链牵引犬齿,弹性链每 2、4、6 或 8 周更换一次。测量每月的犬齿回缩率。计算空间关闭的时间。统计分析:卡普兰-梅耶生存分析和弗里德曼检验对各组进行了评估和比较:结果:各组间的每月犬齿退缩率和第一磨牙中位偏移无明显差异。2周重新激活组的空间闭合平均时间为5.74个月,在统计学上少于其他组:结论:间隔两周重新激活可缩短间隙关闭时间。结论:2周的再激活间隔可缩短空间闭合时间。使用微型螺钉进行直接锚固控制可显著限制锚固丧失。
{"title":"Space Closure with Different Appointment Intervals: A Split-mouth Randomized Controlled Trial.","authors":"Hend Salah ElSayed, Amr Ragab El-Beialy, Juan Martin Palomo, Yehya Ahmad Mostafa","doi":"10.4103/ccd.ccd_617_21","DOIUrl":"10.4103/ccd.ccd_617_21","url":null,"abstract":"<p><strong>Background: </strong>Canine retraction has been successful with various force systems and retraction techniques. The appointment interval for force reactivation in canine retraction along the archwire is 4-8 weeks.</p><p><strong>Aims: </strong>The aim was to evaluate the effect of different reactivation intervals on the rate of space closure.</p><p><strong>Settings and design: </strong>This split-mouth randomized clinical trial recruited 38 patients indicated for the first premolar extraction.</p><p><strong>Methods: </strong>Monthly digital models were acquired for 6 months. The first premolars were extracted, and temporary anchorage devices were placed for maximum anchorage control. The canines were retracted using elastomeric chains which were replaced every 2, 4, 6, or 8 weeks. The monthly rate of canine retraction was measured. The time to space closure was calculated. The secondary outcome was the mesial drift of the first molars.</p><p><strong>Statistical analysis: </strong>The Kaplan-Meier survival analysis and the Friedman test evaluated and compared the groups.</p><p><strong>Results: </strong>There was no significant difference between the monthly canine retraction rate or the first molar mesial drift between the groups. The mean time to space closure was 5.74 months in the 2-week reactivation group, which was statistically less than the other groups.</p><p><strong>Conclusions: </strong>The 2-week reactivation interval may reduce time to space closure. Direct anchorage control with miniscrews limited anchorage loss significantly.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"129-134"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Performance of Zirconia Reinforced versus Conventional Viscous Glass Ionomer in Class I Cavities of Geriatric Patients: A 1-year Randomized Controlled Clinical Trial. 氧化锆增强型与传统粘性玻璃离子黏合剂在老年患者 I 类龋洞中的临床表现:为期一年的随机对照临床试验。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_440_23
Doaa Abdou, Mai Akah, Rania Sayed Mosallam, Omaima Mohamed Safwat

Background: For the elderly population, efforts are made to simplify the restorative procedure while maintaining good clinical performance. Glass ionomer (GI) cements are showing signs to fulfill many of these qualities. With their new properties and ease of use, they can be developed further to become a useful group of materials to overcome the problems of elderly patients.

Aim: The aim of the study was to evaluate the clinical performance of zirconia-reinforced versus conventional viscous GI restorations in Class I cavities of geriatric patients.

Setting and design: The study design was in vivo randomized clinical trial, parallel-arms, allocation ratio: 1:1.

Subjects and methods: A total of 28 Class I carious lesions in 21 geriatric patients were restored randomly either by zirconomer-improved or Ketac Molar Quick Aplicap (n = 14) each. Restorations were evaluated for 1 year by modified USPHS criteria.

Statistical analysis: Data were analyzed with the Chi-square test and Cochran's Q-test. Survival rate was analyzed using the Kaplan-Meier and log-rank test.

Results: Twenty-four restorations were evaluated in 19 patients with a recall rate of 85.7% at 12 months. Significant differences were found in marginal integrity and marginal discoloration within both restorative materials between different time intervals (P < 0.05). However, none of the materials were superior to another regarding all assessed criteria.

Conclusions: Both zirconia-reinforced GI and conventional highly viscous GI have acceptable clinical performance.

背景:对于老年人群来说,如何在保持良好临床表现的同时简化修复程序是一项艰巨的任务。玻璃离聚体(GI)水门汀正显示出满足上述许多质量要求的迹象。目的:该研究旨在评估氧化锆增强型与传统粘性玻璃离子水门汀修复体在老年患者I类牙洞中的临床表现:研究设计为体内随机临床试验,平行臂,分配比例:1:1:21名老年病患者的28个I类龋洞被随机修复,每种修复体均采用zirconomer-improved或Ketac Molar Quick Aplicap(n = 14)。根据修改后的 USPHS 标准对修复体进行为期 1 年的评估:数据分析采用Chi-square检验和Cochran's Q检验。采用 Kaplan-Meier 和对数秩检验分析存活率:对 19 名患者的 24 个修复体进行了评估,12 个月后的回收率为 85.7%。两种修复材料的边缘完整性和边缘变色在不同时间间隔内存在显著差异(P < 0.05)。然而,就所有评估标准而言,没有一种材料优于另一种材料:结论:氧化锆增强 GI 和传统高粘度 GI 的临床表现均可接受。
{"title":"Clinical Performance of Zirconia Reinforced versus Conventional Viscous Glass Ionomer in Class I Cavities of Geriatric Patients: A 1-year Randomized Controlled Clinical Trial.","authors":"Doaa Abdou, Mai Akah, Rania Sayed Mosallam, Omaima Mohamed Safwat","doi":"10.4103/ccd.ccd_440_23","DOIUrl":"10.4103/ccd.ccd_440_23","url":null,"abstract":"<p><strong>Background: </strong>For the elderly population, efforts are made to simplify the restorative procedure while maintaining good clinical performance. Glass ionomer (GI) cements are showing signs to fulfill many of these qualities. With their new properties and ease of use, they can be developed further to become a useful group of materials to overcome the problems of elderly patients.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the clinical performance of zirconia-reinforced versus conventional viscous GI restorations in Class I cavities of geriatric patients.</p><p><strong>Setting and design: </strong>The study design was <i>in vivo</i> randomized clinical trial, parallel-arms, allocation ratio: 1:1.</p><p><strong>Subjects and methods: </strong>A total of 28 Class I carious lesions in 21 geriatric patients were restored randomly either by zirconomer-improved or Ketac Molar Quick Aplicap (<i>n</i> = 14) each. Restorations were evaluated for 1 year by modified USPHS criteria.</p><p><strong>Statistical analysis: </strong>Data were analyzed with the Chi-square test and Cochran's Q-test. Survival rate was analyzed using the Kaplan-Meier and log-rank test.</p><p><strong>Results: </strong>Twenty-four restorations were evaluated in 19 patients with a recall rate of 85.7% at 12 months. Significant differences were found in marginal integrity and marginal discoloration within both restorative materials between different time intervals (<i>P</i> < 0.05). However, none of the materials were superior to another regarding all assessed criteria.</p><p><strong>Conclusions: </strong>Both zirconia-reinforced GI and conventional highly viscous GI have acceptable clinical performance.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"98-104"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Ulcerative Lesions with Low-level Laser Therapy in a Patient with SARS-CoV-2. 用低强度激光疗法治疗一名 SARS-CoV-2 患者的溃疡性病变。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_399_23
Evllen do Vale Castro, Joao Victor de Paula Freitas, Francisco Artur Forte Oliveira, Lucas Alexandre Maia, Thinali Sousa Dantas, Clarissa Pessoa Fernandes Forte

Ulcerated lesions have been observed in SARS-CoV-2 patients and their treatment is a challenge. We aim to report the treatment of oral lesions with low-level laser therapy (LLLT) in a patient with SARS-CoV-2. The patient diagnosed with COVID-19 was admitted to the intensive care unit, on mechanical ventilation, and on a nasogastric tube diet that persisted due to oral lesions. Painful ulcerated lesions, clinically diagnosed as viral ulcer, were found on the tongue, palate, labial commissure, and oropharynx during the oral evaluation. An antimicrobial photodynamic therapy with methylene blue and red laser (high energy) was performed, followed by treatment with LLLT with red laser. Significant clinical improvement of the lesions was observed after seven sessions of LLLT, with the oral diet being reestablished. Oral mucosal lesions in patients with COVID-19 are usually symptomatic and with onset after systemic symptoms. LLLT has been used in the management of these lesions, with promising results.

在 SARS-CoV-2 患者中发现了溃疡性病变,其治疗是一项挑战。我们旨在报告用低强度激光疗法(LLLT)治疗一名 SARS-CoV-2 患者口腔病变的情况。这名被确诊为 COVID-19 的患者被送入重症监护室,接受机械通气和鼻胃管饮食,由于口腔病变,患者的饮食一直没有得到改善。在口腔检查中发现,患者的舌头、上颚、唇交界处和口咽部出现疼痛性溃疡,临床诊断为病毒性溃疡。患者接受了亚甲蓝和红色激光(高能量)的抗菌光动力疗法,随后又接受了红色激光的 LLLT 治疗。经过七个疗程的 LLLT 治疗后,病变有了明显的临床改善,并恢复了口腔饮食。COVID-19 患者的口腔黏膜病变通常是无症状的,在全身症状出现后发病。LLLT 已被用于治疗这些病变,并取得了良好的效果。
{"title":"Treatment of Ulcerative Lesions with Low-level Laser Therapy in a Patient with SARS-CoV-2.","authors":"Evllen do Vale Castro, Joao Victor de Paula Freitas, Francisco Artur Forte Oliveira, Lucas Alexandre Maia, Thinali Sousa Dantas, Clarissa Pessoa Fernandes Forte","doi":"10.4103/ccd.ccd_399_23","DOIUrl":"10.4103/ccd.ccd_399_23","url":null,"abstract":"<p><p>Ulcerated lesions have been observed in SARS-CoV-2 patients and their treatment is a challenge. We aim to report the treatment of oral lesions with low-level laser therapy (LLLT) in a patient with SARS-CoV-2. The patient diagnosed with COVID-19 was admitted to the intensive care unit, on mechanical ventilation, and on a nasogastric tube diet that persisted due to oral lesions. Painful ulcerated lesions, clinically diagnosed as viral ulcer, were found on the tongue, palate, labial commissure, and oropharynx during the oral evaluation. An antimicrobial photodynamic therapy with methylene blue and red laser (high energy) was performed, followed by treatment with LLLT with red laser. Significant clinical improvement of the lesions was observed after seven sessions of LLLT, with the oral diet being reestablished. Oral mucosal lesions in patients with COVID-19 are usually symptomatic and with onset after systemic symptoms. LLLT has been used in the management of these lesions, with promising results.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"138-142"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immediate Implant Placement in Conjunction with Maxillary Sinus Lifting and Grafting. 即刻植入种植体与上颌窦提升和植骨术的结合
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_216_23
Salah Sakka

Bone deficiency in the posterior maxillary bone can be associated with a large sinus cavity and this dilemma can limit implant placement for dental rehabilitation in this area. The maxillary sinus lifting technique can be the solution for many clinical situations with minimal bone height, allowing the placement of longer implants. Autogenous bone graft is a safe and reliable material for reconstructive surgery. In this article, a case of an elderly male patient with inadequate maxillary bone height is presented. Simultaneous maxillary sinus elevation and implant placement with autogenous parietal bone graft were performed.

上颌骨后部的骨缺损可能与较大的上颌窦腔有关,这一难题会限制在这一区域植入种植体进行牙齿修复。上颌窦提升技术可以解决许多骨高度极低的临床情况,允许植入较长的种植体。自体骨移植是一种安全可靠的重建手术材料。本文介绍了一例上颌骨高度不足的老年男性患者。患者同时进行了上颌窦抬高手术和自体顶骨移植种植体植入手术。
{"title":"Immediate Implant Placement in Conjunction with Maxillary Sinus Lifting and Grafting.","authors":"Salah Sakka","doi":"10.4103/ccd.ccd_216_23","DOIUrl":"10.4103/ccd.ccd_216_23","url":null,"abstract":"<p><p>Bone deficiency in the posterior maxillary bone can be associated with a large sinus cavity and this dilemma can limit implant placement for dental rehabilitation in this area. The maxillary sinus lifting technique can be the solution for many clinical situations with minimal bone height, allowing the placement of longer implants. Autogenous bone graft is a safe and reliable material for reconstructive surgery. In this article, a case of an elderly male patient with inadequate maxillary bone height is presented. Simultaneous maxillary sinus elevation and implant placement with autogenous parietal bone graft were performed.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"135-137"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Conventional and Microsurgical Access Flap Procedure in Managing Chronic Periodontitis: A Randomized Controlled Trial. 在治疗慢性牙周炎中比较传统和显微外科入路皮瓣术:随机对照试验
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_151_23
A B Archana, Roshni Ramesh, Jacob Varghese, S Anoop

Aim: The aim of the study was to evaluate and compare the periodontal treatment outcomes in patients with periodontitis treated using conventional and microsurgical access flap procedure.

Materials and methods: Fifty chronic periodontitis patients were randomly assigned to conventional (Group I) and microsurgical (Group II) open flap debridement procedure. The parameters measured were probing pocket depth, clinical attachment loss (CAL), gingival recession (GR), bleeding on probing (BOP), wound healing, and postoperative pain. PD, CAL, GR, and BOP were assessed at pretreatment (baseline) and 3 months postoperatively. Wound healing was assessed using Landrey et al. healing index at 7th day and 3 months postoperatively and postoperative pain was assessed using number of analgesics taken for 7 days following surgery.

Results: Healing Index score of 4 (very good healing) was found in 40% of sites of Group I and 95% of sites of Group II. Comparison of number of analgesics taken between groups on day 7 showed a statistically significant difference (P < 0.01), indicating that pain was significantly reduced in Group II compared to Group I. At 3 months postoperatively, there was no significant reduction in PD, CAL, GR, and BOP between the groups.

Conclusions: In open flap debridement procedure, a microsurgical approach can substantially improve the early healing and induce less postoperative pain when compared to a conventional macroscopic approach.

目的:该研究旨在评估和比较使用传统和显微外科手术入路翻瓣术治疗牙周炎患者的牙周治疗效果:将 50 名慢性牙周炎患者随机分配到传统(I 组)和显微外科(II 组)开放式翻瓣清创术中。测量参数包括探诊袋深度、临床附着丧失(CAL)、牙龈退缩(GR)、探诊出血(BOP)、伤口愈合和术后疼痛。PD、CAL、GR和BOP分别在治疗前(基线)和术后3个月进行评估。伤口愈合情况采用 Landrey 等人的愈合指数在术后第 7 天和 3 个月进行评估,术后疼痛情况采用术后 7 天内服用镇痛药的次数进行评估:结果:愈合指数为 4 分(愈合非常好)的占第一组的 40%,占第二组的 95%。术后 3 个月,各组间的 PD、CAL、GR 和 BOP 均无明显下降:结论:在开放性皮瓣清创术中,与传统的大切口方法相比,显微外科方法可大大改善早期愈合,并减轻术后疼痛。
{"title":"Comparison of Conventional and Microsurgical Access Flap Procedure in Managing Chronic Periodontitis: A Randomized Controlled Trial.","authors":"A B Archana, Roshni Ramesh, Jacob Varghese, S Anoop","doi":"10.4103/ccd.ccd_151_23","DOIUrl":"10.4103/ccd.ccd_151_23","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to evaluate and compare the periodontal treatment outcomes in patients with periodontitis treated using conventional and microsurgical access flap procedure.</p><p><strong>Materials and methods: </strong>Fifty chronic periodontitis patients were randomly assigned to conventional (Group I) and microsurgical (Group II) open flap debridement procedure. The parameters measured were probing pocket depth, clinical attachment loss (CAL), gingival recession (GR), bleeding on probing (BOP), wound healing, and postoperative pain. PD, CAL, GR, and BOP were assessed at pretreatment (baseline) and 3 months postoperatively. Wound healing was assessed using Landrey et al. healing index at 7th day and 3 months postoperatively and postoperative pain was assessed using number of analgesics taken for 7 days following surgery.</p><p><strong>Results: </strong>Healing Index score of 4 (very good healing) was found in 40% of sites of Group I and 95% of sites of Group II. Comparison of number of analgesics taken between groups on day 7 showed a statistically significant difference (<i>P</i> < 0.01), indicating that pain was significantly reduced in Group II compared to Group I. At 3 months postoperatively, there was no significant reduction in PD, CAL, GR, and BOP between the groups.</p><p><strong>Conclusions: </strong>In open flap debridement procedure, a microsurgical approach can substantially improve the early healing and induce less postoperative pain when compared to a conventional macroscopic approach.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"118-123"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Combination of Beta-tricalcium Phosphate, Plasmogel, and Platelet-rich Plasma Improves Long-term Bone Tissue Restoration after Complicated Lower Third Molar Surgery: A Nonrandomized Controlled Trial. β-磷酸三钙、Plasmogel 和富血小板血浆的组合可改善并发症下第三磨牙手术后的长期骨组织修复:非随机对照试验。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_544_23
Madina Amanzholovna Mugalbayeva, Ulmeken Rakhimovna Mirzakulova, Gulbaran Baigazinovna Zaitenova, Zharkinbek Shertajuly Uglanov

Background: A surgical removal of the lower third molars can lead to a number of complications, and bone restoration typically takes a large amount of time. The aim of the study was to investigate the effect of the combination of beta-tricalcium phosphate (β-TCP), plasmogel, and platelet-rich plasma on postsurgery bone tissue restoration by means of X-ray.

Subjects and methods: A total of 200 patients who underwent a complicated removal of the lower third molars were nonrandomly assigned to the experimental (EXP, n = 100) or control (CTR, n = 100) group. In the EXP group patients, sockets were filled with a combination of β-TCP, plasmogel, and platelet-rich plasma. In the CTR group, sockets were not treated. X-ray examinations were performed 3, 6, and 9 months (T1, T2, and T3) postsurgery to define bone quality on the Misch scale. The Mann-Whitney U-test was used for between-group comparison.

Results: Aside from the overconsumption of sugars (more frequently in CTR) and marginally significant sex ratio difference (more females in CTR), the groups were equivalent. Although both groups improved on bone density with time, the EXP group demonstrated greater restoration at T1 (U = 3431, P < 0.001), T2 (U = 3190, P < 0.001), and T3 (U = 3505, P < 0.001) related to a greater percentage of D2 (dense thick porous cortical bone on the ridge and a coarse underlying trabecular bone).

Conclusion: A combination of β-TCP, plasmogel, and platelet-rich plasma, compared to no treatment, facilitates bone tissue restoration after complicated surgical removal of the lower third molars.

背景:手术拔除下第三磨牙会导致一系列并发症,而骨修复通常需要大量时间。本研究旨在通过 X 射线研究β-磷酸三钙(β-TCP)、血浆凝胶和富血小板血浆的组合对术后骨组织修复的影响:共有 200 名接受复杂下第三磨牙拔除术的患者被非随机分配到实验组(EXP,n = 100)或对照组(CTR,n = 100)。在 EXP 组患者中,牙槽窝由 β-TCP、血浆凝胶和富血小板血浆组合填充。CTR 组患者的牙槽窝未进行处理。术后 3、6 和 9 个月(T1、T2 和 T3)进行 X 光检查,根据 Misch 标度确定骨质情况。组间比较采用 Mann-Whitney U 检验:除了糖类摄入过多(CTR 组更经常摄入糖类)和性别比例差异略微显著(CTR 组女性更多)之外,两组患者的情况相当。虽然随着时间的推移,两组的骨密度都有所提高,但 EXP 组在 T1(U = 3431,P < 0.001)、T2(U = 3190,P < 0.001)和 T3(U = 3505,P < 0.001)时的骨密度恢复程度更高,这与 D2(嵴上致密的厚多孔皮质骨和底层粗小梁骨)的比例更高有关:结论:与不采取任何治疗措施相比,β-TCP、血浆凝胶和富血小板血浆联合疗法有助于下第三磨牙复杂手术切除后的骨组织恢复。
{"title":"A Combination of Beta-tricalcium Phosphate, Plasmogel, and Platelet-rich Plasma Improves Long-term Bone Tissue Restoration after Complicated Lower Third Molar Surgery: A Nonrandomized Controlled Trial.","authors":"Madina Amanzholovna Mugalbayeva, Ulmeken Rakhimovna Mirzakulova, Gulbaran Baigazinovna Zaitenova, Zharkinbek Shertajuly Uglanov","doi":"10.4103/ccd.ccd_544_23","DOIUrl":"10.4103/ccd.ccd_544_23","url":null,"abstract":"<p><strong>Background: </strong>A surgical removal of the lower third molars can lead to a number of complications, and bone restoration typically takes a large amount of time. The aim of the study was to investigate the effect of the combination of beta-tricalcium phosphate (β-TCP), plasmogel, and platelet-rich plasma on postsurgery bone tissue restoration by means of X-ray.</p><p><strong>Subjects and methods: </strong>A total of 200 patients who underwent a complicated removal of the lower third molars were nonrandomly assigned to the experimental (EXP, <i>n</i> = 100) or control (CTR, <i>n</i> = 100) group. In the EXP group patients, sockets were filled with a combination of β-TCP, plasmogel, and platelet-rich plasma. In the CTR group, sockets were not treated. X-ray examinations were performed 3, 6, and 9 months (T1, T2, and T3) postsurgery to define bone quality on the Misch scale. The Mann-Whitney <i>U</i>-test was used for between-group comparison.</p><p><strong>Results: </strong>Aside from the overconsumption of sugars (more frequently in CTR) and marginally significant sex ratio difference (more females in CTR), the groups were equivalent. Although both groups improved on bone density with time, the EXP group demonstrated greater restoration at T1 (<i>U</i> = 3431, <i>P</i> < 0.001), T2 (<i>U</i> = 3190, <i>P</i> < 0.001), and T3 (<i>U</i> = 3505, <i>P</i> < 0.001) related to a greater percentage of D2 (dense thick porous cortical bone on the ridge and a coarse underlying trabecular bone).</p><p><strong>Conclusion: </strong>A combination of β-TCP, plasmogel, and platelet-rich plasma, compared to no treatment, facilitates bone tissue restoration after complicated surgical removal of the lower third molars.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"84-88"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Sagittal Condylar Guidance Angle Obtained by Radiographic Methods and Manual Programming of Articulators in Dentate Patients - A Clinico-radiographic Study. 牙病患者髁突矢状面引导角度的放射学方法与手动编程关节器的比较--一项临床放射学研究。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_268_23
Nikita Agrawal, Shobha Janette Rodrigues, M Mahesh, Thilak B Shetty, Umesh Y Pai, Sharon Saldanha, Puneeth Hegde, Junaid Ahmed, N Srikant

Background: The ultimate goal of advanced procedures in prosthetic dentistry is to construct a prosthesis based on the accurate reproduction of condylar guidance.

Aim: To compare the sagittal condylar inclination obtained using the cone-beam computed tomography (CBCT), panoramic image, and two articulator systems.

Settings and design: A cross-sectional study was carried out in 20 dentate patients in the age group of 20-40 years.

Materials and methods: Sagittal condylar guidance angles (SCGAs) were measured on two semi-adjustable articulators (Hanau Wide Vue and Denar Mark 320) using protrusive interocclusal record. SCGAs were also measured on the CBCT scans (CBCT reconstructed panoramic image and CBCT sagittal cross section) and the panoramic images obtained from the patients. The angles were determined on the radiographs by joining two lines: Frankfort's horizontal plane and the other plane were drawn by connecting the superior-most point on the glenoid fossa and the inferior-most point on the articular eminence. All the measurements were done twice by two operators independently.

Statistical analysis used: The data were analyzed using the paired t-test and Pearson's correlation coefficient with a P ≤ 0.05.

Results: There was no significant difference between the right and the left side in any of the groups (P ≥ 0.05). In addition, there was no significant difference between the clinical methods (P ≥ 0.05). However, there was a significant difference between the clinical and the radiographic methods (P ≤ 0.05). Furthermore, there was a strong correlation between the clinical and radiographic methods with Pearson's Correlation coefficient above 0.67.

Conclusion: There is a strong correlation between the clinical and radiographic methods. Thus, CBCT and OPG can be used an adjunct to clinical methods to record sagittal condylar guidance.

背景:目的:比较使用锥束计算机断层扫描(CBCT)、全景图像和两种铰接系统获得的髁状突矢状倾角:材料与方法:对 20 名 20-40 岁年龄组的牙病患者进行横断面研究:使用突出咬合间记录,在两个半可调发音器(Hanau Wide Vue 和 Denar Mark 320)上测量髁状突引导角(SCGA)。此外,还在 CBCT 扫描(CBCT 重建全景图像和 CBCT 矢状横截面图像)和从患者处获得的全景图像上测量了 SCGA。角度是通过连接两条线在 X 光片上确定的:法兰克福水平面和另一个平面是通过连接盂窝的最上点和关节突的最下点绘制的。所有测量均由两名操作员独立完成两次:数据采用配对 t 检验和皮尔逊相关系数进行分析,P ≤ 0.05:结果:各组的左右侧均无明显差异(P≥0.05)。此外,临床方法之间也无明显差异(P≥0.05)。但是,临床方法与放射学方法之间存在明显差异(P≤0.05)。此外,临床方法与放射学方法之间存在很强的相关性,皮尔逊相关系数高于 0.67:结论:临床方法和放射学方法之间有很强的相关性。因此,CBCT 和 OPG 可作为临床方法的辅助工具,用于记录髁状突矢状面引导。
{"title":"Comparison of Sagittal Condylar Guidance Angle Obtained by Radiographic Methods and Manual Programming of Articulators in Dentate Patients - A Clinico-radiographic Study.","authors":"Nikita Agrawal, Shobha Janette Rodrigues, M Mahesh, Thilak B Shetty, Umesh Y Pai, Sharon Saldanha, Puneeth Hegde, Junaid Ahmed, N Srikant","doi":"10.4103/ccd.ccd_268_23","DOIUrl":"10.4103/ccd.ccd_268_23","url":null,"abstract":"<p><strong>Background: </strong>The ultimate goal of advanced procedures in prosthetic dentistry is to construct a prosthesis based on the accurate reproduction of condylar guidance.</p><p><strong>Aim: </strong>To compare the sagittal condylar inclination obtained using the cone-beam computed tomography (CBCT), panoramic image, and two articulator systems.</p><p><strong>Settings and design: </strong>A cross-sectional study was carried out in 20 dentate patients in the age group of 20-40 years.</p><p><strong>Materials and methods: </strong>Sagittal condylar guidance angles (SCGAs) were measured on two semi-adjustable articulators (Hanau Wide Vue and Denar Mark 320) using protrusive interocclusal record. SCGAs were also measured on the CBCT scans (CBCT reconstructed panoramic image and CBCT sagittal cross section) and the panoramic images obtained from the patients. The angles were determined on the radiographs by joining two lines: Frankfort's horizontal plane and the other plane were drawn by connecting the superior-most point on the glenoid fossa and the inferior-most point on the articular eminence. All the measurements were done twice by two operators independently.</p><p><strong>Statistical analysis used: </strong>The data were analyzed using the paired <i>t</i>-test and Pearson's correlation coefficient with a <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>There was no significant difference between the right and the left side in any of the groups (<i>P</i> ≥ 0.05). In addition, there was no significant difference between the clinical methods (<i>P</i> ≥ 0.05). However, there was a significant difference between the clinical and the radiographic methods (<i>P</i> ≤ 0.05). Furthermore, there was a strong correlation between the clinical and radiographic methods with Pearson's Correlation coefficient above 0.67.</p><p><strong>Conclusion: </strong>There is a strong correlation between the clinical and radiographic methods. Thus, CBCT and OPG can be used an adjunct to clinical methods to record sagittal condylar guidance.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"105-112"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Evaluation of Periodontal Ligament-associated Protein-1/Asporin Levels in Periodontal Tissue in Health and Disease. 健康和疾病牙周组织中牙周韧带相关蛋白-1/孢子蛋白水平的比较评估
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_114_23
Madhu Priya Manohar, R Saravana Kumar, Pratebha Balu

Background: Periodontal ligament-associated protein-1 (PLAP-1)/asporin is an extracellular matrix protein that plays a protective role in the pathogenesis of periodontitis. There is a paucity of information about the association between PLAP-1/asporin and periodontitis in human PDL. Thus, in this study, PLAP-1/asporin levels between participants with healthy periodontium and chronic periodontitis were compared and correlated with periodontal parameters.

Materials and methods: Fifty participants were recruited and divided into 25 in each group: Group 1 (control) and Group 2 (test). Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded. Periodontal ligament (PDL) samples were collected from extracted teeth for estimating PLAP-1/asporin levels using the Human Asporin Enzyme-Linked Immunoassay Kit.

Results: A statistically significant difference (P = 0.001) in the PLAP-1/asporin levels was observed between Group 1 and Group 2. A weak negative correlation was observed between PLAP-1/asporin levels and periodontal parameters (PPD and CAL) in both groups.

Conclusion: In this study, higher PLAP-1/asporin levels in participants with healthy periodontium highlight the protective role of PLAP-1/asporin in maintaining periodontal homeostasis.

背景:牙周韧带相关蛋白-1(PLAP-1)/asporin是一种细胞外基质蛋白,在牙周炎的发病机制中起保护作用。关于 PLAP-1/asporin 与人类牙周韧带中牙周炎的关系的信息还很少。因此,本研究比较了健康牙周和慢性牙周炎参与者的 PLAP-1/asporin 水平,并将其与牙周参数相关联:招募 50 名参与者,每组 25 人:第一组(对照组)和第二组(测试组)。记录探诊袋深度(PPD)和临床附着水平(CAL)。从拔出的牙齿中采集牙周韧带(PDL)样本,使用人类阿斯匹林酶联免疫测定试剂盒估算 PLAP-1/asporin 水平:第 1 组和第 2 组的 PLAP-1/asporin 水平差异有统计学意义(P = 0.001)。两组的 PLAP-1/asporin 水平与牙周参数(PPD 和 CAL)之间呈弱负相关:结论:在本研究中,牙周健康者的 PLAP-1/asporin 水平较高,这凸显了 PLAP-1/asporin 在维持牙周平衡方面的保护作用。
{"title":"Comparative Evaluation of Periodontal Ligament-associated Protein-1/Asporin Levels in Periodontal Tissue in Health and Disease.","authors":"Madhu Priya Manohar, R Saravana Kumar, Pratebha Balu","doi":"10.4103/ccd.ccd_114_23","DOIUrl":"10.4103/ccd.ccd_114_23","url":null,"abstract":"<p><strong>Background: </strong>Periodontal ligament-associated protein-1 (PLAP-1)/asporin is an extracellular matrix protein that plays a protective role in the pathogenesis of periodontitis. There is a paucity of information about the association between PLAP-1/asporin and periodontitis in human PDL. Thus, in this study, PLAP-1/asporin levels between participants with healthy periodontium and chronic periodontitis were compared and correlated with periodontal parameters.</p><p><strong>Materials and methods: </strong>Fifty participants were recruited and divided into 25 in each group: Group 1 (control) and Group 2 (test). Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded. Periodontal ligament (PDL) samples were collected from extracted teeth for estimating PLAP-1/asporin levels using the Human Asporin Enzyme-Linked Immunoassay Kit.</p><p><strong>Results: </strong>A statistically significant difference (<i>P</i> = 0.001) in the PLAP-1/asporin levels was observed between Group 1 and Group 2. A weak negative correlation was observed between PLAP-1/asporin levels and periodontal parameters (PPD and CAL) in both groups.</p><p><strong>Conclusion: </strong>In this study, higher PLAP-1/asporin levels in participants with healthy periodontium highlight the protective role of PLAP-1/asporin in maintaining periodontal homeostasis.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"143-146"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Character Strength Profile Related to Courage as Virtue among Dental Professionals. 与牙科专业人员的勇气美德相关的品格力量概况。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_35_24
Supriya, Rajbir Singh, Amra Ahsan

Background: In the background of reported high distress among medical students and health professionals, character building at the level of health institutions may be helpful for augmenting academic performance and nurturing well-being during the training period of budding health professionals.

Aim: This study aims to assess non-cognitive positive traits, particularly Values in Action-character strengths related to the virtue of courage among trainees and doctors. It may reveal the association of challenging situations being faced in health profession with inculcation of the virtue of courage.

Materials and methods: Data regarding character strengths profile with reference to the psychological virtue of courage among students and residents of dental institution (n = 54) were collected and analyzed.

Results: Participants of all the three groups were found to display at least a minimum of each of the character strengths included in the virtue of courage. Perseverance was significantly higher in postgraduate students than undergraduate students and senior residents. Recurrent physician burnout has been reported to be associated with distress symptoms during their medical education at least once.

Conclusion: Positive institutions may play an important role to reduce the intensity and incidence of distress sequelae among medical students by taking initiatives for character building, with reference to augmenting character strengths of virtue of courage.

背景:目的:本研究旨在评估受训者和医生的非认知积极特质,尤其是与勇气美德相关的行动价值--性格优势。材料与方法:收集并分析了牙科院校学生和住院医师(54 人)与勇气心理美德相关的性格优势概况数据:结果:发现所有三组参与者都至少表现出勇气美德所包含的每一种性格优势。研究生的毅力明显高于本科生和资深住院医师。据报道,反复出现的医生职业倦怠至少与一次医学教育期间的痛苦症状有关:结论:积极的教育机构可以发挥重要作用,通过加强勇气美德中的品格力量来培养医学生的品格,从而降低医学生痛苦后遗症的强度和发生率。
{"title":"Character Strength Profile Related to Courage as Virtue among Dental Professionals.","authors":"Supriya, Rajbir Singh, Amra Ahsan","doi":"10.4103/ccd.ccd_35_24","DOIUrl":"10.4103/ccd.ccd_35_24","url":null,"abstract":"<p><strong>Background: </strong>In the background of reported high distress among medical students and health professionals, character building at the level of health institutions may be helpful for augmenting academic performance and nurturing well-being during the training period of budding health professionals.</p><p><strong>Aim: </strong>This study aims to assess non-cognitive positive traits, particularly Values in Action-character strengths related to the virtue of courage among trainees and doctors. It may reveal the association of challenging situations being faced in health profession with inculcation of the virtue of courage.</p><p><strong>Materials and methods: </strong>Data regarding character strengths profile with reference to the psychological virtue of courage among students and residents of dental institution (<i>n</i> = 54) were collected and analyzed.</p><p><strong>Results: </strong>Participants of all the three groups were found to display at least a minimum of each of the character strengths included in the virtue of courage. Perseverance was significantly higher in postgraduate students than undergraduate students and senior residents. Recurrent physician burnout has been reported to be associated with distress symptoms during their medical education at least once.</p><p><strong>Conclusion: </strong>Positive institutions may play an important role to reduce the intensity and incidence of distress sequelae among medical students by taking initiatives for character building, with reference to augmenting character strengths of virtue of courage.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"89-97"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Topical Application of Chum Salmon (Oncorhynchus keta) Skin-derived Collagen Extracts in Improving Oral Traumatic Ulcer Healing. 局部应用大马哈鱼(Oncorhynchus keta)皮肤胶原提取物改善口腔创伤溃疡愈合的功效
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI: 10.4103/ccd.ccd_544_22
Dian Mulawarmanti, Syamsulina Revianti, Endah Wahjuningsih

Background: Traumatic ulcer is a wound on the oral mucosa that often causes pain and impaired eating function. Healing of these wounds takes a long time and can interfere with an individual's daily activities. One therapeutic approach that is being developed is the use of topical application of chum salmon skin-derived collagen extract. Collagen is the main component of the extracellular matrix and plays a major role in wound healing. The skin of chum salmon (Oncorhynchus keta) contains collagen that is effective for the treatment of wounds.

Aim: The aim of this study was to evaluate the effectiveness of topical applications of chum salmon (O. keta) skin-derived collagen extracts in improving the healing of traumatic ulcers through analysis of neutrophil and macrophage numbers and collagen density.

Materials and methods: Twenty-four male Wistar rats were randomly divided into four groups consisting of six rats each. The labial mucosa of the lower lips of the rats was injured with heated amalgam stoppers to create oral traumatic ulcers. Group 1 was a control group; in Groups 2, 3, and 4, 25%, 50%, and 75% of collagen extracts from chum salmon (O. keta) skin were applied topically once a day for 7 days, respectively. The neutrophil and macrophage numbers were observed by hematoxylin and eosin staining. Masson's Trichrome staining was used to analyze the collagen density. Data were analyzed using one-way analysis of variance and continued with post hoc least significant difference tests. Significance is considered if P < 0.05.

Results: The oral traumatic ulcers gradually healed until day 7. The number of neutrophils and macrophages was significantly decreased in the treatment groups, and collagen density was increased, compared to the control group (P < 0.05). The decrease of neutrophil and macrophage numbers occurred significantly with the increased collagen extract concentrations (P < 0.05). Collagen density also increased significantly with the increased collagen extract concentrations (P < 0.05).

Conclusion: Topical applications of chum salmon (O. keta) skin-derived collagen extracts accelerate the healing process of oral traumatic ulcers by decreasing neutrophil and macrophage numbers and increasing collagen density.

背景:外伤性溃疡是口腔黏膜上的伤口,通常会引起疼痛并影响进食功能。这些伤口的愈合需要很长时间,会影响个人的日常活动。目前正在开发的一种治疗方法是局部使用大马哈鱼皮提取的胶原蛋白。胶原蛋白是细胞外基质的主要成分,在伤口愈合中发挥着重要作用。目的:本研究旨在通过分析中性粒细胞和巨噬细胞数量以及胶原蛋白密度,评估局部应用大马哈鱼(O. keta)皮源胶原蛋白提取物在改善创伤性溃疡愈合方面的效果:将 24 只雄性 Wistar 大鼠随机分为 4 组,每组 6 只。用加热的汞合金塞子损伤大鼠下唇的唇粘膜,形成口腔创伤性溃疡。第 1 组为对照组;第 2、3 和 4 组分别局部涂抹 25%、50% 和 75% 的大马哈鱼(O. keta)皮肤胶原提取物,每天一次,连续 7 天。用苏木精和伊红染色法观察中性粒细胞和巨噬细胞的数量。Masson 三色染色用于分析胶原蛋白密度。数据采用单因素方差分析,并继续进行事后最小显著性差异检验。P<0.05为差异有显著性:口腔创伤溃疡在第 7 天前逐渐愈合。与对照组相比,治疗组的中性粒细胞和巨噬细胞数量明显减少,胶原蛋白密度增加(P < 0.05)。随着胶原蛋白提取物浓度的增加,中性粒细胞和巨噬细胞的数量明显减少(P < 0.05)。胶原蛋白密度也随着胶原蛋白提取物浓度的增加而明显增加(P < 0.05):大马哈鱼(O. keta)皮肤胶原蛋白提取物的局部应用可减少中性粒细胞和巨噬细胞的数量并增加胶原蛋白密度,从而加速口腔创伤性溃疡的愈合过程。
{"title":"Efficacy of Topical Application of Chum Salmon (<i>Oncorhynchus keta</i>) Skin-derived Collagen Extracts in Improving Oral Traumatic Ulcer Healing.","authors":"Dian Mulawarmanti, Syamsulina Revianti, Endah Wahjuningsih","doi":"10.4103/ccd.ccd_544_22","DOIUrl":"10.4103/ccd.ccd_544_22","url":null,"abstract":"<p><strong>Background: </strong>Traumatic ulcer is a wound on the oral mucosa that often causes pain and impaired eating function. Healing of these wounds takes a long time and can interfere with an individual's daily activities. One therapeutic approach that is being developed is the use of topical application of chum salmon skin-derived collagen extract. Collagen is the main component of the extracellular matrix and plays a major role in wound healing. The skin of chum salmon (<i>Oncorhynchus</i> <i>keta</i>) contains collagen that is effective for the treatment of wounds.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the effectiveness of topical applications of chum salmon (<i>O.</i> <i>keta</i>) skin-derived collagen extracts in improving the healing of traumatic ulcers through analysis of neutrophil and macrophage numbers and collagen density.</p><p><strong>Materials and methods: </strong>Twenty-four male Wistar rats were randomly divided into four groups consisting of six rats each. The labial mucosa of the lower lips of the rats was injured with heated amalgam stoppers to create oral traumatic ulcers. Group 1 was a control group; in Groups 2, 3, and 4, 25%, 50%, and 75% of collagen extracts from chum salmon (<i>O.</i> <i>keta</i>) skin were applied topically once a day for 7 days, respectively. The neutrophil and macrophage numbers were observed by hematoxylin and eosin staining. Masson's Trichrome staining was used to analyze the collagen density. Data were analyzed using one-way analysis of variance and continued with <i>post hoc</i> least significant difference tests. Significance is considered if <i>P</i> < 0.05.</p><p><strong>Results: </strong>The oral traumatic ulcers gradually healed until day 7. The number of neutrophils and macrophages was significantly decreased in the treatment groups, and collagen density was increased, compared to the control group (<i>P</i> < 0.05). The decrease of neutrophil and macrophage numbers occurred significantly with the increased collagen extract concentrations (<i>P</i> < 0.05). Collagen density also increased significantly with the increased collagen extract concentrations (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Topical applications of chum salmon (<i>O.</i> <i>keta</i>) skin-derived collagen extracts accelerate the healing process of oral traumatic ulcers by decreasing neutrophil and macrophage numbers and increasing collagen density.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"124-128"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Contemporary Clinical Dentistry
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1