Pub Date : 2022-10-01Epub Date: 2022-11-11DOI: 10.4103/ccd.ccd_531_21
Trupti Vijay Gaikwad, Anuj Paul Maini, Sukanya Das, Sayali Lokhande, Shruti K Patil, Arunima Sarma
Mucocele is a common salivary gland lesion which most commonly occurs on the lower lip. Several treatment options are available for its elimination with surgery being the most commonly used method. A 49-year-old male presented with a small, round, painless swelling on the left buccal mucosa since 6 months. A clinical diagnosis of oral mucocele on the left buccal mucosa was made. Due to the inaccessibility of the posterior buccal mucosa region, sclerotherapy with sodium tetradecyl sulfate was planned. The patient did not show any obvious reduction in the size of swelling after 1 week of therapy. Therefore, a second injection was planned. After another 1 week, complete resolution of the lesion was seen with no complications. No recurrence of the lesion has been seen after 6 months of therapy. Due to the various drawbacks of surgical management of oral mucocele, sclerotherapy can be an effective alternative.
{"title":"Nonsurgical Management of Oral Mucocele Occurring on a Rare Site.","authors":"Trupti Vijay Gaikwad, Anuj Paul Maini, Sukanya Das, Sayali Lokhande, Shruti K Patil, Arunima Sarma","doi":"10.4103/ccd.ccd_531_21","DOIUrl":"10.4103/ccd.ccd_531_21","url":null,"abstract":"<p><p>Mucocele is a common salivary gland lesion which most commonly occurs on the lower lip. Several treatment options are available for its elimination with surgery being the most commonly used method. A 49-year-old male presented with a small, round, painless swelling on the left buccal mucosa since 6 months. A clinical diagnosis of oral mucocele on the left buccal mucosa was made. Due to the inaccessibility of the posterior buccal mucosa region, sclerotherapy with sodium tetradecyl sulfate was planned. The patient did not show any obvious reduction in the size of swelling after 1 week of therapy. Therefore, a second injection was planned. After another 1 week, complete resolution of the lesion was seen with no complications. No recurrence of the lesion has been seen after 6 months of therapy. Due to the various drawbacks of surgical management of oral mucocele, sclerotherapy can be an effective alternative.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/e9/CCD-13-389.PMC9855259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10582840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is a confusion regarding selection of unfilled or filled sealant and method of enamel preparation before sealant application. This study was carried out to compare three techniques of enamel preparation using both unfilled and filled type of sealants.
Objective: The objective of the study is to assess the penetrative and adaptive ability of filled and unfilled sealants in three techniques of enamel fissure preparations.
Materials and methods: Total 36 extracted teeth were divided into 3 groups, each containing 12 samples. The samples of Group A were prepared by conventional acid etching with 37% phosphoric acid, and the Group B was subjected to Er: YAG lasing, while in Group C, fissurotomy followed by acid etching was done. The sealant placement was carried out using split tooth design in all the samples. Assessment of penetration and adaptation was done under scanning electron microscope using the scoring criteria adopted by Kane B et al. and Dukic W et al.
Results: Group A and Group C showed better adaptation than Group B. Statistically, no significant difference was observed in the penetration property among three techniques. Similarly, the unfilled and filled sealant showed statistically nonsignificant results for the penetration and adaptation comparison.
Conclusion: Irrespective of the sealant material selected, the conventional method of acid etching alone or in conjunction with fissurotomy bur for better retentiveness seems to be an acceptable choice of treatment modality. The study will help the clinicians to choose the sealant material and technique of enamel preparation.
{"title":"Comparative Evaluation of Penetrative and Adaptive Properties of Unfilled and Filled Resin-Based Sealants When Placed using Conventional acid Etching, Lasing, and Fissurotomy Bur Technique of Enamel Preparation: An <i>in vitro</i> Scanning Electron Microscope Study.","authors":"Poonam Ramrao Shingare, Vishwas Chaugule, Neha Pankey, Pallavi Kakade","doi":"10.4103/ccd.ccd_227_21","DOIUrl":"10.4103/ccd.ccd_227_21","url":null,"abstract":"<p><strong>Background: </strong>There is a confusion regarding selection of unfilled or filled sealant and method of enamel preparation before sealant application. This study was carried out to compare three techniques of enamel preparation using both unfilled and filled type of sealants.</p><p><strong>Objective: </strong>The objective of the study is to assess the penetrative and adaptive ability of filled and unfilled sealants in three techniques of enamel fissure preparations.</p><p><strong>Materials and methods: </strong>Total 36 extracted teeth were divided into 3 groups, each containing 12 samples. The samples of Group A were prepared by conventional acid etching with 37% phosphoric acid, and the Group B was subjected to Er: YAG lasing, while in Group C, fissurotomy followed by acid etching was done. The sealant placement was carried out using split tooth design in all the samples. Assessment of penetration and adaptation was done under scanning electron microscope using the scoring criteria adopted by Kane B <i>et al</i>. and Dukic W <i>et al</i>.</p><p><strong>Results: </strong>Group A and Group C showed better adaptation than Group B. Statistically, no significant difference was observed in the penetration property among three techniques. Similarly, the unfilled and filled sealant showed statistically nonsignificant results for the penetration and adaptation comparison.</p><p><strong>Conclusion: </strong>Irrespective of the sealant material selected, the conventional method of acid etching alone or in conjunction with fissurotomy bur for better retentiveness seems to be an acceptable choice of treatment modality. The study will help the clinicians to choose the sealant material and technique of enamel preparation.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/76/CCD-13-349.PMC9855269.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10582842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01Epub Date: 2022-11-03DOI: 10.4103/ccd.ccd_408_21
Zaneta Ivy D'Souza, Shumail Sattar, Mukul Padhye, Rajiv S Desai
The term surgical ciliated cyst of the maxilla is a designation for cysts of the maxillary sinus conventionally associated with surgery and trauma. Surgical ciliated cysts with a noncontributory history of surgery or trauma can pose a diagnostic challenge. We report an interesting case of ciliated cyst of the maxilla in a 54-year-old male patient. The present case provides a plausible explanation for the occurrence of ciliated cyst of the maxilla lacking history of surgery or trauma.
{"title":"Non-Surgical Ciliated Cyst of the Maxilla - An Unconventional Variant.","authors":"Zaneta Ivy D'Souza, Shumail Sattar, Mukul Padhye, Rajiv S Desai","doi":"10.4103/ccd.ccd_408_21","DOIUrl":"10.4103/ccd.ccd_408_21","url":null,"abstract":"<p><p>The term surgical ciliated cyst of the maxilla is a designation for cysts of the maxillary sinus conventionally associated with surgery and trauma. Surgical ciliated cysts with a noncontributory history of surgery or trauma can pose a diagnostic challenge. We report an interesting case of ciliated cyst of the maxilla in a 54-year-old male patient. The present case provides a plausible explanation for the occurrence of ciliated cyst of the maxilla lacking history of surgery or trauma.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/20/CCD-13-392.PMC9855262.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01Epub Date: 2022-11-03DOI: 10.4103/ccd.ccd_432_21
Shraddha C Jugade, Supriya Bhalchim, Amey Karkhanis
Parathyroid hormone (PTH) plays a key role in the regulation of calcium homeostasis. It is secreted by a pair of parathyroid glands located behind the thyroid gland. Primary hyperparathyroidism is the disorder which is seen in 0.2%-0.3% of the population. It is the third most common endocrine disorder after Diabetes Mellitus and Thyroid disorders. There are several systemic manifestations of the disease including skeletal, Renal, abdominal, neurological ones. The following case report discusses some of the classic oral manifestations of the disease and signifies the role of an Oral physician in the diagnosis of underlying systemic disorder.
{"title":"Role of Oral Physician in Diagnosis of Occult Disease of Primary Hyperparathyroidism.","authors":"Shraddha C Jugade, Supriya Bhalchim, Amey Karkhanis","doi":"10.4103/ccd.ccd_432_21","DOIUrl":"10.4103/ccd.ccd_432_21","url":null,"abstract":"<p><p>Parathyroid hormone (PTH) plays a key role in the regulation of calcium homeostasis. It is secreted by a pair of parathyroid glands located behind the thyroid gland. Primary hyperparathyroidism is the disorder which is seen in 0.2%-0.3% of the population. It is the third most common endocrine disorder after Diabetes Mellitus and Thyroid disorders. There are several systemic manifestations of the disease including skeletal, Renal, abdominal, neurological ones. The following case report discusses some of the classic oral manifestations of the disease and signifies the role of an Oral physician in the diagnosis of underlying systemic disorder.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/cf/CCD-13-395.PMC9855267.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01Epub Date: 2022-12-01DOI: 10.4103/ccd.ccd_385_22
Himali Gupta, Arpit Gupta, Sanjeev Verma, Satinder Pal Singh
Objective: The objective of this study was to compare the effect of miniscrew-supported maxillary incisor intrusion and conventional intrusion mechanics on maxillary incisors and molar inclination.
Material and methods: Search databases (PubMed, Scopus, Web of Science, Embase, EBSCOhost, and the Cochrane Library) were searched for randomized trials on intrusion of maxillary incisors via miniscrew-supported and conventional mechanics. The revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0) was used. Five outcomes ([i] inclination change of upper incisors, [ii] inclination change of upper molars, [iii] intrusion of incisors, [iv] vertical change in upper first molars, and [v] overbite correction achieved) were statistically pooled using Review Manager 5.3. Subgroup analysis was conducted to receive sturdiness in meta-analysis. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation.
Results: Out of 1777 studies, 7 were finally subjected to quality assessment, and 6 were included in the meta-analysis. The incisor inclination following maxillary incisor intrusion increased in miniscrew-supported intrusion in comparison to Connecticut intrusion arch (CTA) subgroup with standard mean difference of 0.66 mm (95% confidence interval = 0.16, 1.03, I2 = 0%). All the included studies showed an increase in molar inclination (distal tipping) in the CTA subgroup compared to the micro-implant group. Of all the seven included studies, only one study was identified with some concerns for the risk of bias, and the other six were judged to have an overall high risk of bias.
Conclusion: The incisal proclination during deep-bite correction by miniscrew-supported incisal intrusion is more than that in the CTA subgroup; however, the difference may not be clinically very relevant. There is a very low quality of evidence in favor of miniscrew-supported intrusion as compared to conventional intrusion, necessitating the need for good-quality trials.
目的:本研究的目的是比较微型螺钉支撑的上颌切牙侵彻和传统的侵彻机制对上颌切牙和磨牙倾斜度的影响。材料和方法:检索数据库(PubMed、Scopus、Web of Science、Embase、EBSCOhost和Cochrane Library),通过迷你小组支持的和传统的力学方法进行上颌切牙侵入的随机试验。使用修订后的随机试验的Cochrane偏倚风险工具(RoB 2.0)。使用Review Manager 5.3对五种结果([i]上切牙倾斜变化,[i]上臼齿倾斜变化,[3i]切牙侵入,[iv]上第一臼齿垂直变化和[v]实现的覆牙矫正)进行统计汇总。进行亚组分析以获得荟萃分析中的稳健性。使用建议评估、发展和评估分级对证据质量进行评估。结果:在1777项研究中,7项最终进行了质量评估,6项纳入荟萃分析。与康涅狄格侵入弓(CTA)亚组相比,小螺钉支持的上颌切牙侵入后的切牙倾斜度增加,标准平均差为0.66mm(95%置信区间=0.16,1.03,I2=0%)。所有纳入的研究均显示,与微型植入物组相比,CTA亚组的磨牙倾斜度(远端倾斜度)增加。在所有七项纳入的研究中,只有一项研究对偏倚风险有一定的担忧,其他六项研究被判断为偏倚风险总体较高。结论:小螺钉支持的切迹侵犯在深部咬合矫正过程中切迹向顺位的发生率高于CTA亚组;然而,这种差异在临床上可能不是很相关。与传统入侵相比,支持迷你船员支持的入侵的证据质量非常低,因此需要进行高质量的试验。
{"title":"Comparing the Effect of Miniscrew-Supported and Conventional Maxillary Incisor Intrusion on the Inclination of Maxillary Incisors and Molars - A Systematic Review and Meta-Analysis.","authors":"Himali Gupta, Arpit Gupta, Sanjeev Verma, Satinder Pal Singh","doi":"10.4103/ccd.ccd_385_22","DOIUrl":"10.4103/ccd.ccd_385_22","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to compare the effect of miniscrew-supported maxillary incisor intrusion and conventional intrusion mechanics on maxillary incisors and molar inclination.</p><p><strong>Material and methods: </strong>Search databases (PubMed, Scopus, Web of Science, Embase, EBSCOhost, and the Cochrane Library) were searched for randomized trials on intrusion of maxillary incisors via miniscrew-supported and conventional mechanics. The revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0) was used. Five outcomes ([i] inclination change of upper incisors, [ii] inclination change of upper molars, [iii] intrusion of incisors, [iv] vertical change in upper first molars, and [v] overbite correction achieved) were statistically pooled using Review Manager 5.3. Subgroup analysis was conducted to receive sturdiness in meta-analysis. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation.</p><p><strong>Results: </strong>Out of 1777 studies, 7 were finally subjected to quality assessment, and 6 were included in the meta-analysis. The incisor inclination following maxillary incisor intrusion increased in miniscrew-supported intrusion in comparison to Connecticut intrusion arch (CTA) subgroup with standard mean difference of 0.66 mm (95% confidence interval = 0.16, 1.03, I<sup>2</sup> = 0%). All the included studies showed an increase in molar inclination (distal tipping) in the CTA subgroup compared to the micro-implant group. Of all the seven included studies, only one study was identified with some concerns for the risk of bias, and the other six were judged to have an overall high risk of bias.</p><p><strong>Conclusion: </strong>The incisal proclination during deep-bite correction by miniscrew-supported incisal intrusion is more than that in the CTA subgroup; however, the difference may not be clinically very relevant. There is a very low quality of evidence in favor of miniscrew-supported intrusion as compared to conventional intrusion, necessitating the need for good-quality trials.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/e9/CCD-13-307.PMC9855268.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01Epub Date: 2022-11-03DOI: 10.4103/ccd.ccd_782_21
M Jemima Judith, Nalini Aswath, Kesavaram Padmavathy
Context: Resistant pathogens to purulent odontogenic infections have evolved due to misuse of antibiotics. Hence, it is important to use a suitable antibacterial agent.
Aim: This study aimed to identify the common bacterial species causing odontogenic infections and to determine their antibiotic susceptibility profile to amoxicillin, amoxicillin and clavulanic acid, azithromycin, and linezolid.
Settings and design: This was an in vitro cross-sectional study.
Material and methods: Fifty pus samples from odontogenic abscess were cultured and antibiotic susceptibility tests were performed as per the standard microbiological procedures.
Statistical analysis used: Binomial test and Pearson's Chi-square test were used for statistical analysis.
Results: Out of the 50 samples cultured, 30 samples showed growth. The distribution of growth among the 30 samples was Gram-positive cocci (n = 23, 67.65%) and Gram-negative bacilli (n = 11, 32.35%). Gram-positive isolates that were grown were Enterococcus faecalis (38.24%) followed by Staphylococcus aureus (29.41%) and Gram-negative bacilli that were isolated were Klebsiella pneumoniae (14.71%), Pseudomonas aeruginosa (8.82%), Escherichia coli (5.88%), and Enterobacter (2.94%). Enterococcus isolates were highly susceptible to amoxicillin (76.92%). An increase in the zone of inhibition to amoxicillin-clavulanic acid was appreciated more for Staphylococcus (50%) than Enterococcus (30.76%). Enterococcus and Staphylococcus showed high susceptibility of 92.31% and 90% to linezolid, respectively. E. coli and Enterobacter were 100% susceptible to amoxicillin. All the Gram-negative bacteria except for P. aeruginosa were 100% highly susceptible to amoxicillin-clavulanic acid.
Conclusions: Culture-guided antibiotic prescriptions are necessary to prevent the emergence of antibiotic-resistant bacteria.
{"title":"Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy.","authors":"M Jemima Judith, Nalini Aswath, Kesavaram Padmavathy","doi":"10.4103/ccd.ccd_782_21","DOIUrl":"10.4103/ccd.ccd_782_21","url":null,"abstract":"<p><strong>Context: </strong>Resistant pathogens to purulent odontogenic infections have evolved due to misuse of antibiotics. Hence, it is important to use a suitable antibacterial agent.</p><p><strong>Aim: </strong>This study aimed to identify the common bacterial species causing odontogenic infections and to determine their antibiotic susceptibility profile to amoxicillin, amoxicillin and clavulanic acid, azithromycin, and linezolid.</p><p><strong>Settings and design: </strong>This was an <i>in vitro</i> cross-sectional study.</p><p><strong>Material and methods: </strong>Fifty pus samples from odontogenic abscess were cultured and antibiotic susceptibility tests were performed as per the standard microbiological procedures.</p><p><strong>Statistical analysis used: </strong>Binomial test and Pearson's Chi-square test were used for statistical analysis.</p><p><strong>Results: </strong>Out of the 50 samples cultured, 30 samples showed growth. The distribution of growth among the 30 samples was Gram-positive cocci (<i>n</i> = 23, 67.65%) and Gram-negative bacilli (<i>n</i> = 11, 32.35%). Gram-positive isolates that were grown were <i>Enterococcus faecalis</i> (38.24%) followed by <i>Staphylococcus aureus</i> (29.41%) and Gram-negative bacilli that were isolated were <i>Klebsiella pneumoniae</i> (14.71%), <i>Pseudomonas aeruginosa</i> (8.82%), <i>Escherichia coli</i> (5.88%), and <i>Enterobacter</i> (2.94%). <i>Enterococcus</i> isolates were highly susceptible to amoxicillin (76.92%). An increase in the zone of inhibition to amoxicillin-clavulanic acid was appreciated more for <i>Staphylococcus</i> (50%) than <i>Enterococcus</i> (30.76%). <i>Enterococcus</i> and <i>Staphylococcus</i> showed high susceptibility of 92.31% and 90% to linezolid, respectively. <i>E. coli</i> and <i>Enterobacter</i> were 100% susceptible to amoxicillin. All the Gram-negative bacteria except for <i>P. aeruginosa</i> were 100% highly susceptible to amoxicillin-clavulanic acid.</p><p><strong>Conclusions: </strong>Culture-guided antibiotic prescriptions are necessary to prevent the emergence of antibiotic-resistant bacteria.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/1e/CCD-13-369.PMC9855256.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10580637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Emerging evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Literature evidence have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium, but the peroxiredoxin-sulfiredoxin system is explored very minimally in periodontal disease. Thus, the present study was aimed to evaluate the genetic association of SRXN1 receptor gene polymorphism (rs6053666).
Materials and methods: A total of 100 subjects were recruited for this study, which included 50 Periodontitis patients (Stage II and above based on the criteria of American Association of Periodontology-2018) and 50 periodontally healthy or mild gingivitis. Genomic DNA was extracted from the whole blood collected from the subjects. DNA was amplified using specific primers flanking the BtgI region of the SRXN1 receptor gene. The amplicon was further subjected to genotyping using restriction fragment length using BtgI enzyme. The genotype obtained based on the restriction fragment length polymorphism pattern was recorded and used for statistical analysis. The distribution of genotypes and allele frequencies in the periodontitis and control groups were compared using the Chi-square test. The risk associated with individual alleles or genotypes was calculated as the odds ratio with 95% confidence intervals. Statistical significance in all tests was determined at P < 0.05.
Results: The genotype frequency and distributions of SRXN1 receptor BtgI polymorphism did not differ significantly at ꭕ2df (P = 0.557). Our study results showed that homozygous and heterozygous mutant genotypes had no significant difference (CC vs. CT + TT) between the periodontitis patients and control group with a P = 0.4266. The detected frequency of CT (38% vs. 34%) and TT (42% vs. 52%) genotype showed no significant difference between control and test group. There was no significant difference in C allele (39% vs. 31%) and T allele (61% vs. 69%) between the test and control group.
Conclusion: The present study denotes that SRXN1 receptor gene polymorphism is not associated with periodontitis in the study group analyzed.
{"title":"Association of SRXN1 Receptor Gene Polymorphism with Susceptibility to Periodontitis.","authors":"Karthikeyan Murthykumar, Sheeja Varghese, Vijayashree Priyadharsini Jayaseelan","doi":"10.4103/ccd.ccd_309_21","DOIUrl":"10.4103/ccd.ccd_309_21","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Literature evidence have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium, but the peroxiredoxin-sulfiredoxin system is explored very minimally in periodontal disease. Thus, the present study was aimed to evaluate the genetic association of SRXN1 receptor gene polymorphism (rs6053666).</p><p><strong>Materials and methods: </strong>A total of 100 subjects were recruited for this study, which included 50 Periodontitis patients (Stage II and above based on the criteria of American Association of Periodontology-2018) and 50 periodontally healthy or mild gingivitis. Genomic DNA was extracted from the whole blood collected from the subjects. DNA was amplified using specific primers flanking the BtgI region of the SRXN1 receptor gene. The amplicon was further subjected to genotyping using restriction fragment length using BtgI enzyme. The genotype obtained based on the restriction fragment length polymorphism pattern was recorded and used for statistical analysis. The distribution of genotypes and allele frequencies in the periodontitis and control groups were compared using the Chi-square test. The risk associated with individual alleles or genotypes was calculated as the odds ratio with 95% confidence intervals. Statistical significance in all tests was determined at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The genotype frequency and distributions of SRXN1 receptor BtgI polymorphism did not differ significantly at ꭕ2df (<i>P</i> = 0.557). Our study results showed that homozygous and heterozygous mutant genotypes had no significant difference (CC vs. CT + TT) between the periodontitis patients and control group with a <i>P</i> = 0.4266. The detected frequency of CT (38% vs. 34%) and TT (42% vs. 52%) genotype showed no significant difference between control and test group. There was no significant difference in C allele (39% vs. 31%) and T allele (61% vs. 69%) between the test and control group.</p><p><strong>Conclusion: </strong>The present study denotes that SRXN1 receptor gene polymorphism is not associated with periodontitis in the study group analyzed.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/f7/CCD-13-363.PMC9855261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10580640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Surface characteristics of resin-based composites (RBCs) can change with polishing and over time.
Aim: The aim of the study was to compare the surface roughness and wettability of three different posterior RBCs after polishing and the change in these surface characteristics over time, after aqueous aging.
Settings and design: Experimental in vitro study.
Materials and methods: Eleven disc-shaped RBC specimens were fabricated. The RBCs used were, alkasite composite, bulk-fill nanocomposite, conventional nanofilled composite. All the specimens underwent polishing with Soflex Diamond Polishing System and then analyzed for roughness and wettability at baseline and after aqueous aging for 3 months with the help of an atomic force microscope and a contact angle goniometer respectively.
Statistical analysis: One-way ANOVA and Tamhane test were used for the multiple comparisons.
Results: Alkasite composite showed significantly higher surface roughness (P = 0.028 and P < 0.001, respectively) and lower wettability (P = 0.023 and P = 0.020, respectively) than conventional nanofilled composite at baseline and 3 months. Surface roughness of alkasite composite was also significantly higher than bulk-fill nanocomposite (P = 0.009 and P < 0.001, respectively) at both the time points.
Conclusions: Alkasite has higher surface roughness in comparison to conventional nanocomposite and bulk-fill nanocomposite and lower wettability than conventional nanocomposite after polishing and aqueous aging over a 3-month period. In terms of surface characteristics, alkasite composite may be advantageous in preventing initial plaque adhesion to the material surface, but the lower surface roughness of nano-filled composites may be more advantageous in terms of plaque retention prevention.
{"title":"Comparative Evaluation of Surface Roughness and Wettability of an Alkasite with Nano Bulk-Fill and Nanofilled Resin Composite Restorative Materials: <i>In vitro</i> Study.","authors":"Shrehya Shekhar, Baranya Shrikrishna Suprabha, Ramya Shenoy, Srikant Natarajan, Arathi Rao","doi":"10.4103/ccd.ccd_95_21","DOIUrl":"10.4103/ccd.ccd_95_21","url":null,"abstract":"<p><strong>Context: </strong>Surface characteristics of resin-based composites (RBCs) can change with polishing and over time.</p><p><strong>Aim: </strong>The aim of the study was to compare the surface roughness and wettability of three different posterior RBCs after polishing and the change in these surface characteristics over time, after aqueous aging.</p><p><strong>Settings and design: </strong>Experimental <i>in vitro</i> study.</p><p><strong>Materials and methods: </strong>Eleven disc-shaped RBC specimens were fabricated. The RBCs used were, alkasite composite, bulk-fill nanocomposite, conventional nanofilled composite. All the specimens underwent polishing with Soflex Diamond Polishing System and then analyzed for roughness and wettability at baseline and after aqueous aging for 3 months with the help of an atomic force microscope and a contact angle goniometer respectively.</p><p><strong>Statistical analysis: </strong>One-way ANOVA and Tamhane test were used for the multiple comparisons.</p><p><strong>Results: </strong>Alkasite composite showed significantly higher surface roughness (<i>P</i> = 0.028 and <i>P</i> < 0.001, respectively) and lower wettability (<i>P</i> = 0.023 and <i>P</i> = 0.020, respectively) than conventional nanofilled composite at baseline and 3 months. Surface roughness of alkasite composite was also significantly higher than bulk-fill nanocomposite (<i>P</i> = 0.009 and <i>P</i> < 0.001, respectively) at both the time points.</p><p><strong>Conclusions: </strong>Alkasite has higher surface roughness in comparison to conventional nanocomposite and bulk-fill nanocomposite and lower wettability than conventional nanocomposite after polishing and aqueous aging over a 3-month period. In terms of surface characteristics, alkasite composite may be advantageous in preventing initial plaque adhesion to the material surface, but the lower surface roughness of nano-filled composites may be more advantageous in terms of plaque retention prevention.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/6f/CCD-13-337.PMC9855263.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10625325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Numerous studies have explored the correlation of periodontal disease (PD) with the risk of lung cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with the risk of incident lung cancer.
Methods: The authors searched relevant studies in databases (PubMed, Web of Science, Scopus, Embase, and MEDLINE) till November 2020. We registered the study at the International database of Prospectively Registered Systemic Reviews under the CRD42020198119. The summary relative risk (RR) along with a 95% confidence interval (CI) was calculated using fixed-effects models.
Results: Twelve studies were included in the qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of lung cancer (RR 1.71; 95%CI 1.61-1.81; P < 0.01). Subgroup analysis was performed based on gender distribution, geographic location, and type of studies.
Conclusion: From this current evidence, PD is a potential risk factor for the development of lung cancer. The risk for incidence of lung cancer is surged twice in the patients with PD, even though age and smoking are controlled in the studies.
背景:许多研究探讨了牙周病(PD)与肺癌风险的相关性,但研究结果并不一致。因此,我们进行了一项荟萃分析,以确定PD与癌症发病风险的相关性。方法:作者在数据库(PubMed、Web of Science、Scopus、Embase和MEDLINE)中搜索相关研究,直到2020年11月。我们在CRD42020198119下的前瞻性注册系统综述国际数据库中注册了这项研究。使用固定效应模型计算汇总相对风险(RR)和95%置信区间(CI)。结果:12项研究被纳入定性综合。汇总分析显示PD与癌症风险增加显著相关(RR 1.71;95%CI 1.61-1.81;P<0.01)。根据性别分布、地理位置和研究类型进行亚组分析。结论:根据目前的证据,PD是癌症发展的潜在危险因素。尽管研究中控制了年龄和吸烟,但帕金森病患者患癌症的风险增加了两倍。
{"title":"Is Periodontitis a Risk Factor for Lung Cancer? A Meta-Analysis and Detailed Review of Mechanisms of Association.","authors":"Pooja Kesharani, Payalben Kansara, Tikal Kansara, Arjun Kini, Raksha Bhat, Preethesh Shetty, Bapanaiah Penugonda","doi":"10.4103/ccd.ccd_117_22","DOIUrl":"10.4103/ccd.ccd_117_22","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have explored the correlation of periodontal disease (PD) with the risk of lung cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with the risk of incident lung cancer.</p><p><strong>Methods: </strong>The authors searched relevant studies in databases (PubMed, Web of Science, Scopus, Embase, and MEDLINE) till November 2020. We registered the study at the International database of Prospectively Registered Systemic Reviews under the CRD42020198119. The summary relative risk (RR) along with a 95% confidence interval (CI) was calculated using fixed-effects models.</p><p><strong>Results: </strong>Twelve studies were included in the qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of lung cancer (RR 1.71; 95%CI 1.61-1.81; <i>P</i> < 0.01). Subgroup analysis was performed based on gender distribution, geographic location, and type of studies.</p><p><strong>Conclusion: </strong>From this current evidence, PD is a potential risk factor for the development of lung cancer. The risk for incidence of lung cancer is surged twice in the patients with PD, even though age and smoking are controlled in the studies.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2e/6d/CCD-13-297.PMC9855255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10582841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01Epub Date: 2022-09-24DOI: 10.4103/ccd.ccd_723_20
Daniel Fernando Hergemöller, André Antonio Pelegrine, Paulo José Pasquali, Luis Guilherme Scavone de Macedo, Marcelo Lucchesi Teixeira, Peter Karyen Moy, Antonio Carlos Aloise
Background: It is known that a large number of mediators involved in osteogenesis can influence bone development and repair; however, whether these mediators could be used as markers of bone maturity has yet to be determined.
Aim: To evaluate the expression of osteocalcin (OC) and Runt-related transcription factor 2 (Runx2) in bone biopsies obtained during the reconstruction of atrophic anterior maxillae using particulate bone xenografts with or without association of autogenous bone marrow aspirate concentrate (BMAC).
Materials and methods: Ten patients were distributed into two groups (n = 5), according to the type of grafting material used: Control group (CG), particulate bone xenograft alone, and test group (TG), particulate bone xenograft combined with BMAC. A bone specimen was removed from the graft area 4 months after grafting, before implant placement. The specimens were processed and submitted to immunohistochemical analysis for detection of OC and Runx2. Histomorphometry was used to ascertain the percentage of stained areas in both groups. The Wilcoxon Mann-Whitney U-Test was used in the statistical analysis (P < 0.05).
Results: The immunohistochemical analysis revealed a significantly higher OC expression in the TG than in the CG, namely 27.40 ± 1.34% and 11.40 ± 2.70%, respectively (P < 0.05), and a significantly higher Runx2 expression in the TG than in the CG, namely 2.80 ± 0.84% and 0.40 ± 0.55%, respectively (P < 0.05).
Conclusion: The OC and Runx2 expression levels were higher when BMAC was associated with the bone xenograft than when it was not.
{"title":"Osteocalcin and Runx2 Expression in Anterior Maxillary Reconstructions Using Bone Xenografts Associated to Bone Marrow Aspirate Concentrate.","authors":"Daniel Fernando Hergemöller, André Antonio Pelegrine, Paulo José Pasquali, Luis Guilherme Scavone de Macedo, Marcelo Lucchesi Teixeira, Peter Karyen Moy, Antonio Carlos Aloise","doi":"10.4103/ccd.ccd_723_20","DOIUrl":"https://doi.org/10.4103/ccd.ccd_723_20","url":null,"abstract":"<p><strong>Background: </strong>It is known that a large number of mediators involved in osteogenesis can influence bone development and repair; however, whether these mediators could be used as markers of bone maturity has yet to be determined.</p><p><strong>Aim: </strong>To evaluate the expression of osteocalcin (OC) and Runt-related transcription factor 2 (Runx2) in bone biopsies obtained during the reconstruction of atrophic anterior maxillae using particulate bone xenografts with or without association of autogenous bone marrow aspirate concentrate (BMAC).</p><p><strong>Materials and methods: </strong>Ten patients were distributed into two groups (<i>n</i> = 5), according to the type of grafting material used: Control group (CG), particulate bone xenograft alone, and test group (TG), particulate bone xenograft combined with BMAC. A bone specimen was removed from the graft area 4 months after grafting, before implant placement. The specimens were processed and submitted to immunohistochemical analysis for detection of OC and Runx2. Histomorphometry was used to ascertain the percentage of stained areas in both groups. The Wilcoxon Mann-Whitney <i>U</i>-Test was used in the statistical analysis (<i>P</i> < 0.05).</p><p><strong>Results: </strong>The immunohistochemical analysis revealed a significantly higher OC expression in the TG than in the CG, namely 27.40 ± 1.34% and 11.40 ± 2.70%, respectively (<i>P</i> < 0.05), and a significantly higher Runx2 expression in the TG than in the CG, namely 2.80 ± 0.84% and 0.40 ± 0.55%, respectively (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The OC and Runx2 expression levels were higher when BMAC was associated with the bone xenograft than when it was not.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/fb/CCD-13-211.PMC9533378.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33498342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}