Contemporary Clinical Dentistry最新文献

Background: Loss of permanent teeth after tooth extraction without replacement of missing teeth can result in impaired masticatory, esthetic, phonetic functions, and impaired balance of the masticatory organ in the mouth. Therefore, a method is needed to inhibit the alveolar bone resorption process so that the dimensions of the tooth socket can be maintained vertically or horizontally until the time of implant placement, which is called the socket preservation procedure. α-mangostin is known to have a potential anti-inflammatory effect and most likely can be used as a potential therapeutic agent to inhibit bone resorption caused by posttooth extraction inflammatory processes.

Aims: The aim of the study was to determine the effect on the inflammatory process and osteogenesis on osteoblast cell line culture by induction with lipopolysaccharide (LPS) and α-mangostin.

Materials and methods: This was an in vitro laboratory experimental study on mouse osteoblast cell line culture. The treatment was given with LPS, α-mangostin, and combination on osteogenic medium, using the same concentration for all concentrates. The sample will then be processed and analyzed using the real-time polymerase chain reaction.

Results: The highest interleukin-11 (IL-11) gene expression was found in α-mangostin treatment, but there was no significant difference in IL-11 expression between the study groups. The highest runt-related transcription factor-2 (RUNX-2) gene expression was found in a group that received induction with LPS and α-mangostin, and from these results, it was found that there was a significant difference in RUNX-2 expression between the study groups.

Conclusions: LPS and α-mangostin can increase osteogenesis in osteoblast cell culture in the osteogenic medium.

Background: Mucormycosis is a rare opportunistic fungal infection, which has a rapidly progressive and fulminant course with fatal outcome. It is the need of the hour to diagnose and treat the increasing cases urgently.

Aim: The aim of this article is to study the common radiographic features of rhinomaxillary mucormycosis (RMM), find diagnostic criteria, and grade the disease according to the radiographic features.

Settings: This study was conducted at Face Three-Dimensional Cone-Beam Computed Tomography (CBCT) Center, Aurangabad, Maharashtra.

Materials and methods: CBCT scans of 30 patients who were referred for CBCT scanning of suspected RMM were retrospectively evaluated for relevant radiological data.

Results: The most common CBCT features of RMM were osteolytic lesions in alveolar bone, palate, nose and nasal cavity, and zygoma along with involvement of paranasal sinuses. About 76.66% of patients had a history of COVID-19 infection.

Conclusion: According to the collected data, the scans of probable rhinomaxillary mucormycosis were graded in three groups - mild, moderate, and severe. The goal of this article is to emphasize the most overlook diagnostic entity - CBCT and its significant importance in early diagnosis, treatment, and prognosis of RMM. Early diagnosis of RMM can save the patients from the extent of morbidity and mortality.

The use of digital smile designing simplifies the restoration of esthetics. In this article, a case of diastema and incisal notching in anterior teeth was rehabilitated with porcelain laminate veneers using combination of digital and analog workflow.

Parallelism to the ala-tragus line is commonly used as a guide for the orientation of the occlusal plane with the help of a fox plane. The accuracy of parallelism is affected by improper judgment or patient movement. This report describes a method with a modified fox plane that aids in occlusal plane determination. The device is placed in the patient's mouth with the maxillary occlusal rim to determine parallelism to the ala-tragus line and interpupillary line. The adjustments are made until the laser light on the device runs parallel to the ala-tragus line, and the spirit bubble is centered between the lines of the tube. This technique facilitates direct visualization of parallelism, thereby avoiding parallax errors.

Background: A reciprocal relationship is understood to exist between periodontal disease and type 2 diabetes mellitus (T2DM), and this intervention study aimed to evaluate the effects of nonsurgical periodontal therapy (NSPT) on metabolic control, systemic inflammation, and cytokines in patients of T2DM with Stage III periodontitis.

Materials and methods: Sixty patients of T2DM with Stage III periodontitis were divided equally into two groups: intervention group (IG) and control group. Clinical parameters such as bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and 3 and 6 months, and the serum samples were collected and processed at baseline and 6 months following NSPT to evaluate fasting plasma glucose, Glycosylated hemoglobin (HbA1c), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and high-sensitivity capsule-reactive protein (hs-CRP).

Results: The results indicated a significant improvement in clinical parameters of PPD and CAL 6 months after NSPT (P = 0.005) in both the groups. However, a significant decrease (P < 0.0001) in the TNF-α, hs-CRP, blood glucose, and HbA1c levels was seen after NSPT. On the other hand, an increase in anti-inflammatory cytokine IL-10 was observed after NSPT in the IG. The changes in the pretreatment and posttreatment levels of all clinical, biochemical, and metabolic parameters, were found to be significant in both the groups except BOP.

Conclusion: NSPT effectively improves periodontal condition, systemic inflammatory status, and glycemic control in patients of T2DM with Stage III periodontitis and decreases hs-CRP levels.

Background: Complete eradication of root canal pathogens cannot be predictably achieved by chemomechanical preparation and root canal disinfection. Therefore, an obturation material that has superior antimicrobial activity and sealing ability is required to inactivate residual microbes and prevent them from reentering the root canal system. Recently developed bioceramic root canal sealers are hydraulic cement which form calcium hydroxide during the hydration process. Like calcium hydroxide sealers, they exert an antimicrobial effect by releasing hydroxyl ions and increasing the pH.

Objective: The objective of this study was to evaluate and compare the antimicrobial activity of a calcium hydroxide-based sealer and two bioceramic sealers against Porphyromonas gingivalis, Enterococcus faecalis, and Candida albicans biofilms.

Materials and methods: The sealers were dissolved in sterile saline to obtain supernatants. Biofilm formation assays, colony counting, and real-time polymerase chain reaction (PCR) were performed to evaluate the antimicrobial activity of each supernatant. The data were analyzed using one-way analysis of variance.

Results: All sealers exerted effects against all three microbial biofilms. The biofilm formation assays showed that the bioceramic sealers were more effective against P. gingivalis and E. faecalis biofilms. In contrast, colony counting and real-time PCR showed that the calcium hydroxide sealer was significantly more effective than the bioceramic sealers. All tests showed that the calcium hydroxide sealer was more effective against C. albicans, with the colony count and real-time PCR results showing statistically significant differences.

Conclusion: The calcium hydroxide-based sealer was more effective than the bioceramic sealers in eradicating pathogenic root canal biofilms.

Objective: The objective of the study is to evaluate the orthodontic treatment effect on maxillary incisors' inclination relative to facial and growth axes in adult subjects.

Materials and methods: Hundred consecutive nongrowing orthodontic patients with an average age of 26.24 ± 9.29 years were selected, and their T1 (initial) and T2 (final) lateral cephalograms were digitized. Cephalometric maxillary incisors' (I) inclination was measured to SN, PP, NA, NBa, and true horizontal (H). Facial and growth axes' inclinations were measured relative to NBa and H. Associations were tested using Chi-square tests for categorical data. Paired sample t-tests and Pearson's correlation were computed for continuous data.

Results: Maxillary incisors' inclination, MP/SN, and ANB angle did not show statistically significant differences between T1 and T2, while mandibular incisors' inclination and interincisal angle increased significantly (P = 0.01 and P = 0.02, respectively). Facial and growth axes increased at T2 but changes were not statistically significant among the two groups. At T1, correlations between maxillary incisors' inclination and facial/growth axes were not statistically significant. Similarly, correlations between MP/SN and ANB angles on the one hand and facial/growth axes on the another hand were not statistically significant. At T2, I/PP correlated significantly with facial axis (FA)/NBa (r = 0.308; P = 0.002) and with FA/H (r = 0.268; P = 0.007). Similarly, I/SN and I/NBa correlated significantly with FA/NBa (r = 0.399; P < 0.0001 and r = 0.422; P < 0.0001 correspondingly) and with FA/H (r = 0.305; P = 0.002 and r = 0.325; P = 0.001 correspondingly). Statistically significant negative correlations existed between MP/SN angle and facial/growth axes at T2 (r values ranging -0.704 to -0.409 at P < 0.0001).

Conclusions: While there was no correlation between I and facial/growth axes at pretreatment, significant and higher correlations existed at the end of the orthodontic treatment. This association reflects the connection between the corrected posttreatment position of maxillary incisors relative to the corresponding vertical pattern. Therefore, orthodontists should evaluate the position of the maxillary incisors to FA and may consider it in their treatment objectives.