Pub Date : 2026-04-01Epub Date: 2025-07-08DOI: 10.1097/RLU.0000000000006045
Yuhu Lv, Mengting Li, Xiaoli Lan, Chunxia Qin
An 80-year-old man underwent 68 Ga-FAPI and 18 F-FDG PET scans to determine the nature of a liver mass that exhibited high FDG uptake unexpectedly but was FAPI-negative. Postoperative pathology confirmed atypical hepatocellular carcinoma (HCC) with extensive steatosis. Intratumoral steatosis is uncommon in large lesions, and extensive steatosis may mask tumor characteristics, which increases diagnostic complexity. This unusual case provides novel insights into the clinical application of FDG and FAPI PET and highlights the importance of recognizing FAPI false-negatives, thereby contributing to clinical practice.
{"title":"FAPI-Negative but FDG-Avid Hepatocellular Carcinoma With Extensive Steatosis.","authors":"Yuhu Lv, Mengting Li, Xiaoli Lan, Chunxia Qin","doi":"10.1097/RLU.0000000000006045","DOIUrl":"10.1097/RLU.0000000000006045","url":null,"abstract":"<p><p>An 80-year-old man underwent 68 Ga-FAPI and 18 F-FDG PET scans to determine the nature of a liver mass that exhibited high FDG uptake unexpectedly but was FAPI-negative. Postoperative pathology confirmed atypical hepatocellular carcinoma (HCC) with extensive steatosis. Intratumoral steatosis is uncommon in large lesions, and extensive steatosis may mask tumor characteristics, which increases diagnostic complexity. This unusual case provides novel insights into the clinical application of FDG and FAPI PET and highlights the importance of recognizing FAPI false-negatives, thereby contributing to clinical practice.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e274-e275"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-07-24DOI: 10.1097/RLU.0000000000006071
Tingting Yuan, Xueqi Chen, Qian Li, Zhanli Fu
A 21-year-old woman presented with left iliac pain for 1 week. Pelvic radiograph and MRI revealed a large osteolytic lesion involving the left ilium and sacrum. PET/CT showed the lesion having a heterogeneous rim 18 F-FDG avidity with a photopenic center. No additional abnormalities were detected on the body and brain PET/CT scans. The subsequent operative pathology confirmed the diagnosis of intraosseous meningiomas.
{"title":"18 F-FDG PET/CT Findings in a Patient With Primary Intraosseous Meningiomas Involving the Ilium and Sacrum.","authors":"Tingting Yuan, Xueqi Chen, Qian Li, Zhanli Fu","doi":"10.1097/RLU.0000000000006071","DOIUrl":"10.1097/RLU.0000000000006071","url":null,"abstract":"<p><p>A 21-year-old woman presented with left iliac pain for 1 week. Pelvic radiograph and MRI revealed a large osteolytic lesion involving the left ilium and sacrum. PET/CT showed the lesion having a heterogeneous rim 18 F-FDG avidity with a photopenic center. No additional abnormalities were detected on the body and brain PET/CT scans. The subsequent operative pathology confirmed the diagnosis of intraosseous meningiomas.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e269-e271"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a 73-year-old man with de novo metastatic prostate cancer who had received chemotherapy and androgen deprivation therapy (ADT). An increase in his serum prostate-specific antigen (PSA) level during ADT prompted a referral for restaging. A 99m Tc-HYNIC-PSMA-11 scintigraphy was conducted, which revealed uptake in the peritoneal cavity that was initially interpreted as normal intestinal excretion on the whole body scan but was later clarified through SPECT/CT imaging. This case underscores the potential of functional imaging, even conventional methods, to surpass anatomical imaging techniques such as CT scans, which have limited soft tissue resolution, in assessing peritoneal involvement.
{"title":"Detection of Peritoneal Carcinomatosis in Prostate Cancer via 99m Tc-HYNIC-PSMA-11 Scintigraphy.","authors":"Nasrin Raeisi, Amin Saber Tanha, Atena Aghaee, Emran Askari, Vahid Reza Dabbagh Kakhki, Ramin Sadeghi","doi":"10.1097/RLU.0000000000005996","DOIUrl":"10.1097/RLU.0000000000005996","url":null,"abstract":"<p><p>We present a 73-year-old man with de novo metastatic prostate cancer who had received chemotherapy and androgen deprivation therapy (ADT). An increase in his serum prostate-specific antigen (PSA) level during ADT prompted a referral for restaging. A 99m Tc-HYNIC-PSMA-11 scintigraphy was conducted, which revealed uptake in the peritoneal cavity that was initially interpreted as normal intestinal excretion on the whole body scan but was later clarified through SPECT/CT imaging. This case underscores the potential of functional imaging, even conventional methods, to surpass anatomical imaging techniques such as CT scans, which have limited soft tissue resolution, in assessing peritoneal involvement.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e239-e240"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-09-10DOI: 10.1097/RLU.0000000000006112
Khulood Al Riyami, Anjali Jain, Asiya Al Busaidi, Anas Al Balushi, Rashid Rasheed, Sharjeel Usmani
PSMA-targeted radioligand therapies with 177 Lu-PSMA-617 have shown promising response rates with favorable toxicity in patients with metastasized castration-resistant prostate cancer. We report a case of a 72-year-old man with metastatic castration-resistant prostate cancer having comorbidities of DM, HTN, and end-stage renal disease (ESRD) on regular hemodialysis. The patient received 2 doses of 7.4GBq of 177 Lu-PSMA-617, 6 weeks apart. There was complete resolution of prior 68 Ga-PSMA avid lesions, a significant decrease in serum PSA level, and symptomatic response after therapy. We suggest that patients with ESRD on dialysis can be safely treated with 177 Lu-PSMA radionuclide therapy.
{"title":"Super Responder of 177 Lu-PSMA-617 PSMA Therapy in Patient With End-Stage Renal Disease on Hemodialysis.","authors":"Khulood Al Riyami, Anjali Jain, Asiya Al Busaidi, Anas Al Balushi, Rashid Rasheed, Sharjeel Usmani","doi":"10.1097/RLU.0000000000006112","DOIUrl":"10.1097/RLU.0000000000006112","url":null,"abstract":"<p><p>PSMA-targeted radioligand therapies with 177 Lu-PSMA-617 have shown promising response rates with favorable toxicity in patients with metastasized castration-resistant prostate cancer. We report a case of a 72-year-old man with metastatic castration-resistant prostate cancer having comorbidities of DM, HTN, and end-stage renal disease (ESRD) on regular hemodialysis. The patient received 2 doses of 7.4GBq of 177 Lu-PSMA-617, 6 weeks apart. There was complete resolution of prior 68 Ga-PSMA avid lesions, a significant decrease in serum PSA level, and symptomatic response after therapy. We suggest that patients with ESRD on dialysis can be safely treated with 177 Lu-PSMA radionuclide therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e276-e277"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-07-21DOI: 10.1097/RLU.0000000000006072
Saiteja Reddy Mallu, Keerti Sitani, Sandip Basu
A comparative evaluation using both 18 F-FDG-PET/CT and 68 Ga-FAPI-04 PET/CT in primary staging of a treatment-naïve anterior mediastinal seminoma is illustrated in this report. A 30-year-old man presented with elevated human chorionic gonadotropin levels and biopsy-proven seminoma of the anterior mediastinum. The investigation was performed for primary staging, considering that both tracers may show uptake in the germ cell tumors in the anterior mediastinum, and the potential role of 68 Ga-FAPI-04 PET/CT in treatment-naïve mediastinal seminoma would be examined. The germ cell tumors comprise 1%-4% of mediastinal tumors, and seminomas are less frequent than non-seminomatous tumors.
{"title":"Comparative Evaluation of 68 Ga-FAPI-04 PET/CT and 18 F-FDG-PET/CT in Primary Staging of Treatment-naïve Anterior Mediastinal Seminoma.","authors":"Saiteja Reddy Mallu, Keerti Sitani, Sandip Basu","doi":"10.1097/RLU.0000000000006072","DOIUrl":"10.1097/RLU.0000000000006072","url":null,"abstract":"<p><p>A comparative evaluation using both 18 F-FDG-PET/CT and 68 Ga-FAPI-04 PET/CT in primary staging of a treatment-naïve anterior mediastinal seminoma is illustrated in this report. A 30-year-old man presented with elevated human chorionic gonadotropin levels and biopsy-proven seminoma of the anterior mediastinum. The investigation was performed for primary staging, considering that both tracers may show uptake in the germ cell tumors in the anterior mediastinum, and the potential role of 68 Ga-FAPI-04 PET/CT in treatment-naïve mediastinal seminoma would be examined. The germ cell tumors comprise 1%-4% of mediastinal tumors, and seminomas are less frequent than non-seminomatous tumors.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e255-e256"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pheochromocytomas are rare catecholamine-secreting tumors arising from the adrenal medulla, often presenting with episodic hypertension, palpitations, and diaphoresis. Meanwhile, undifferentiated carcinoma of the uterine corpus is an aggressive and poorly differentiated endometrial malignancy with a high propensity for metastasis and poor prognosis. The incidental detection of such an aggressive malignancy in a patient undergoing evaluation for pheochromocytoma is exceedingly rare and poses significant diagnostic and therapeutic challenges. Here, we present a case of a 63-year-old woman who was being evaluated for right pheochromocytoma and underwent 131 I-MIBG scan for the same, which led to incidental detection of synchronous uterine carcinoma.
{"title":"131 I-MIBG and 18 F-FDG PET/CT in a Case of Synchronous Right Pheochromocytoma and Undifferentiated Uterine Carcinoma.","authors":"Yamini Dharmashaktu, Ritwik Wakankar, Shamim A Shamim, Akhil Venugopal, Seema Singhal","doi":"10.1097/RLU.0000000000006115","DOIUrl":"10.1097/RLU.0000000000006115","url":null,"abstract":"<p><p>Pheochromocytomas are rare catecholamine-secreting tumors arising from the adrenal medulla, often presenting with episodic hypertension, palpitations, and diaphoresis. Meanwhile, undifferentiated carcinoma of the uterine corpus is an aggressive and poorly differentiated endometrial malignancy with a high propensity for metastasis and poor prognosis. The incidental detection of such an aggressive malignancy in a patient undergoing evaluation for pheochromocytoma is exceedingly rare and poses significant diagnostic and therapeutic challenges. Here, we present a case of a 63-year-old woman who was being evaluated for right pheochromocytoma and underwent 131 I-MIBG scan for the same, which led to incidental detection of synchronous uterine carcinoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e281-e282"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2025-10-07DOI: 10.1097/RLU.0000000000006156
Merve Nida Calderon Tobar, Hasan Önner, Ahmet Görgel
Von Hippel-Lindau (VHL) disease is a rare, autosomal dominant, multisystem cancer syndrome. A variety of benign and malignant tumors can develop in VHL, including cranial and spinal hemangioblastomas, retinoblastoma, endolymphatic sac tumor, pheochromocytoma, renal cell carcinoma, pancreatic neuroendocrine tumors, and renal, pancreatic, and genital cysts. Here we present a 57-year-old woman who was diagnosed with VHL and, in the same 68 Ga-DOTATATE PET/CT, exhibits all these components of the syndrome: pheochromocytoma, pancreatic neuroendocrine tumor, pancreatic cysts, renal cysts, liver hemangioma, and hemangioblastoma in the medulla oblongata.
Von Hippel-Lindau (VHL)病是一种罕见的常染色体显性多系统癌症综合征。VHL可发生多种良性和恶性肿瘤,包括颅内和脊髓血管母细胞瘤、视网膜母细胞瘤、内淋巴囊瘤、嗜铬细胞瘤、肾细胞癌、胰腺神经内分泌肿瘤以及肾、胰腺和生殖器囊肿。在这里,我们报告了一位57岁的女性,她被诊断为VHL,并在相同的68Ga-DOTATATE PET/CT上显示出该综合征的所有组成部分:嗜铬细胞瘤,胰腺神经内分泌肿瘤,胰腺囊肿,肾囊肿,肝脏血管瘤和延髓内的血管母细胞瘤。
{"title":"All-in-One Case: Comprehensive Detection of VHL Syndrome With 68 Ga-DOTATATE PET/CT.","authors":"Merve Nida Calderon Tobar, Hasan Önner, Ahmet Görgel","doi":"10.1097/RLU.0000000000006156","DOIUrl":"10.1097/RLU.0000000000006156","url":null,"abstract":"<p><p>Von Hippel-Lindau (VHL) disease is a rare, autosomal dominant, multisystem cancer syndrome. A variety of benign and malignant tumors can develop in VHL, including cranial and spinal hemangioblastomas, retinoblastoma, endolymphatic sac tumor, pheochromocytoma, renal cell carcinoma, pancreatic neuroendocrine tumors, and renal, pancreatic, and genital cysts. Here we present a 57-year-old woman who was diagnosed with VHL and, in the same 68 Ga-DOTATATE PET/CT, exhibits all these components of the syndrome: pheochromocytoma, pancreatic neuroendocrine tumor, pancreatic cysts, renal cysts, liver hemangioma, and hemangioblastoma in the medulla oblongata.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e262-e263"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-15DOI: 10.1097/RLU.0000000000006305
Lei Yang, Dongling Zhu, Shuang Song, Sijuan Zou, Xiaohua Zhu
We presented the imaging findings of 18 F-FDG and 68 Ga-HER2 affibody PET/CT in a 52-year-old woman with HER2-positive accessory breast cancer in the right axilla. 18 F-FDG and HER2 PET/CT showed avid uptake of multiple axillary lesions. HER2 PET/CT identified extensive bone metastases with intense uptake, while the ⁹⁹ᵐTc-MDP whole bone scan was negative, and only a few bone lesions with mild tracer uptake were detected by 18 F-FDG PET/CT. Following 6 cycles of the TCbHP regimen, the axillary lesions markedly reduced. This case demonstrates that HER2 PET/CT enables more sensitive detection of HER2-positive lesions, thereby allowing for precise staging and guiding HER2-targeted therapy.
{"title":"Ultra-Sensitive Detection of Bone Metastasis From Accessory Breast Cancer Using HER2 PET/CT: A Case Report.","authors":"Lei Yang, Dongling Zhu, Shuang Song, Sijuan Zou, Xiaohua Zhu","doi":"10.1097/RLU.0000000000006305","DOIUrl":"10.1097/RLU.0000000000006305","url":null,"abstract":"<p><p>We presented the imaging findings of 18 F-FDG and 68 Ga-HER2 affibody PET/CT in a 52-year-old woman with HER2-positive accessory breast cancer in the right axilla. 18 F-FDG and HER2 PET/CT showed avid uptake of multiple axillary lesions. HER2 PET/CT identified extensive bone metastases with intense uptake, while the ⁹⁹ᵐTc-MDP whole bone scan was negative, and only a few bone lesions with mild tracer uptake were detected by 18 F-FDG PET/CT. Following 6 cycles of the TCbHP regimen, the axillary lesions markedly reduced. This case demonstrates that HER2 PET/CT enables more sensitive detection of HER2-positive lesions, thereby allowing for precise staging and guiding HER2-targeted therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"362-364"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-03-02DOI: 10.1097/RLU.0000000000006336
Jian Geng, Jie Luo, Fang Huang, Jianjun Qian, Xiaoyuan Chu
Follicular dendritic cell sarcoma (FDCS) of the duodenum is extremely rare. We describe the contrast-enhanced CT and FDG PET/CT findings in a case of duodenal FDCS. Contrast-enhanced CT revealed a large, irregular mass originating from the horizontal portion of the duodenum. The mass demonstrated heterogeneous enhancement, with internal areas of low-attenuation necrosis and coarse calcifications. The mass showed significantly increased FDG uptake. The patient underwent surgical resection, and histopathologic examination revealed a spindle cell tumor positive for CD21 and CD35, confirming the diagnosis of FDCS.
{"title":"FDG PET/CT in Duodenal Follicular Dendritic Cell Sarcoma.","authors":"Jian Geng, Jie Luo, Fang Huang, Jianjun Qian, Xiaoyuan Chu","doi":"10.1097/RLU.0000000000006336","DOIUrl":"10.1097/RLU.0000000000006336","url":null,"abstract":"<p><p>Follicular dendritic cell sarcoma (FDCS) of the duodenum is extremely rare. We describe the contrast-enhanced CT and FDG PET/CT findings in a case of duodenal FDCS. Contrast-enhanced CT revealed a large, irregular mass originating from the horizontal portion of the duodenum. The mass demonstrated heterogeneous enhancement, with internal areas of low-attenuation necrosis and coarse calcifications. The mass showed significantly increased FDG uptake. The patient underwent surgical resection, and histopathologic examination revealed a spindle cell tumor positive for CD21 and CD35, confirming the diagnosis of FDCS.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"51 4","pages":"346-348"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 58-year-old woman presented with disabling bone pain and muscle weakness. Laboratory tests were unremarkable, except for decreased serum phosphate and elevated urine phosphate levels. A 99m Tc-MDP scan revealed multiple sites of bone fractures. Both 18 F-FDG PET/CT and 99m Tc-FAPI-46 scans identified a lesion in the left heel, which was later resected and diagnosed as phosphaturic mesenchymal tumor on pathologic evaluation. This case represents a pioneering experience in utilizing FAPI for detecting the origin of tumor-induced osteomalacia. It underscores the potential utility of various radiopharmaceuticals in the diagnostic workup of these patients.
{"title":"Phosphaturic Mesenchymal Tumor in the Foot Detected by 99m Tc-FAPI-46 SPECT/CT and 18 F-FDG PET/CT.","authors":"Nasrin Raeisi, Amin Saber Tanha, Zohreh Mosavi, Alireza Mousavian, Ramin Sadeghi","doi":"10.1097/RLU.0000000000006016","DOIUrl":"10.1097/RLU.0000000000006016","url":null,"abstract":"<p><p>A 58-year-old woman presented with disabling bone pain and muscle weakness. Laboratory tests were unremarkable, except for decreased serum phosphate and elevated urine phosphate levels. A 99m Tc-MDP scan revealed multiple sites of bone fractures. Both 18 F-FDG PET/CT and 99m Tc-FAPI-46 scans identified a lesion in the left heel, which was later resected and diagnosed as phosphaturic mesenchymal tumor on pathologic evaluation. This case represents a pioneering experience in utilizing FAPI for detecting the origin of tumor-induced osteomalacia. It underscores the potential utility of various radiopharmaceuticals in the diagnostic workup of these patients.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e241-e243"},"PeriodicalIF":9.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}