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Localization of Parathyroid Adenoma With 68 Ga-NODAGA-RGD PET/CT and Demonstration of "Metabolic Superscan" With Lincoln Sign and Costochondral Junction Beading : A Potential Clinical Application. 68Ga-NODAGA-RGD PET/CT定位甲状旁腺瘤及“代谢超扫描”显示林肯征及肋软骨连接处串珠:潜在的临床应用
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-06-05 DOI: 10.1097/RLU.0000000000006013
Priyanka Verma, Mali Madhava Reddy, Anurag Lila, Sandip Basu

In primary hyperparathyroidism (PHPT), exact preoperative localization of parathyroid adenomas is essential for best surgical planning. While new PET tracers like 18 F-fluorocholine and 68 Ga-Trivehexin show promise, traditional imaging consists of 99m Tc-Sestamibi scintigraphy, SPECT/CT, and 4DCT. Herein, we report the potential new application of another angiogenesis imaging agent, 68 Ga-NODAGA-RGD PET/CT, illustrated in a 12-year-old girl with PHPT. The scan revealed diffuse skeletal tracer uptake (superscan) in addition to localizing right inferior parathyroid adenoma, thereby indicating systemic effects. This case underscores 68 Ga-RGD PET/CT as a possible instrument for parathyroid imaging and systemic evaluation, justifying more research to define its diagnostic value and role in treatment response evaluation.

在原发性甲状旁腺功能亢进(PHPT),准确的术前定位甲状旁腺瘤是必不可少的最佳手术计划。虽然新的PET示踪剂如18f -氟胆碱和68Ga-Trivehexin显示出希望,但传统的成像包括99mTc-Sestamibi科学成像、SPECT/CT和4DCT。在此,我们报告了另一种血管生成显像剂的潜在新应用,68Ga-NODAGA-RGD PET/CT,显示了一名12岁的PHPT女孩。扫描显示弥漫性骨骼示踪剂摄取(超扫描),并定位右侧下甲状旁腺瘤,从而表明全身影响。本病例强调了68Ga-RGD PET/CT作为甲状旁腺成像和系统评估的可能工具,需要更多的研究来确定其诊断价值和在治疗反应评估中的作用。
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引用次数: 0
Hepatic Eosinophilic Granuloma Mimicking Liver Metastases of Unknown Primary Focus on 18 F-FDG and 68 Ga-FAPI PET/CT. 18F-FDG和68Ga-FAPI PET/CT显示肝脏嗜酸性肉芽肿模拟未知原发灶肝转移。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-05-13 DOI: 10.1097/RLU.0000000000005970
Meng Dai, Kai Yang, Xiujuan Zhao, Jingmian Zhang, Xinming Zhao

A 53-year-old man presented with right upper abdominal pain for more than 3 weeks without an apparent cause. Multiple sequences of MR imaging detected multiple liver nodules with irregular peripheral enhancement. 18 F-FDG and 68 Ga-FAPI PET showed multiple elevated tracer uptake, which mimicked multiple liver metastases of unknown primary focus. Finally, the pathology of ultrasound-guided biopsy confirmed the diagnosis of hepatic eosinophilic granuloma (HEG).

一个53岁的男人表现为右上腹部疼痛超过3周,没有明显的原因。多序列磁共振成像发现多发肝结节,周围增强不规则。18F-FDG和68Ga-FAPI PET显示多重示踪剂摄取升高,这模拟了原发性病灶未知的多重肝转移。超声引导下病理活检证实肝嗜酸性肉芽肿(HEG)。
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引用次数: 0
18 F-FDG PET/CT Findings in an Atypical Case of Glial Fibrillary Acidic Protein Meningomyelitis. 不典型胶质纤维酸性蛋白脑脊炎1例的18F-FDG PET/CT表现
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-11-07 DOI: 10.1097/RLU.0000000000005992
Yamini Dharmashaktu, Ritwik Nitin Wakankar, Akhil Venugopal, Rakesh Kumar

Gilal fibrillary acidic protein (GFAP) meningomyelitis is a rare autoimmune inflammatory disorder of the central nervous system, typically presenting with subacute encephalopathy, ataxia, optic neuritis, and cerebrospinal fluid (CSF) pleocytosis. It is characterized by the presence of GFAP-specific autoantibodies, which target astrocytes and cause widespread neuroinflammation. 18 F-FDG PET/CT plays a critical role in the early diagnosis of autoimmune encephalitides, particularly in cases where conventional MRI findings may be subtle or nonspecific. Here, we present a case of 21-year-old woman who presented with early morning occipital headache with fever, followed by progressive drowsiness and acute urinary retention. On clinical examination, meningeal signs were positive. MRI brain was suggestive of leptomeningeal enhancement involving the brain and spinal cord, and 18 F-FDG PET/CT was done for further evaluation.

Gilal fibrillary acid protein (GFAP) meningomyelitis是一种罕见的中枢神经系统自身免疫性炎症性疾病,典型表现为亚急性脑病、共济失调、视神经炎和脑脊液(CSF)多细胞症。它的特点是存在gfap特异性自身抗体,其目标是星形胶质细胞并引起广泛的神经炎症。18F-FDG PET/CT在自身免疫性脑肽的早期诊断中起着至关重要的作用,特别是在常规MRI发现可能不明显或非特异性的情况下。在这里,我们提出一个21岁的女性谁提出了清晨枕部头痛发烧,随后进行性嗜睡和急性尿潴留。临床检查,脑膜征为阳性。脑MRI提示轻脑膜增强累及脑和脊髓,并做18F-FDG PET/CT进一步评估。
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引用次数: 0
Pulmonary Air Leak SPECT/CT in a Mechanically Ventilated Intensive Care Patient. 机械通气重症监护患者肺漏气SPECT/CT分析。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1097/RLU.0000000000006281
Korbinian Krieger, Benedikt Florian Scherr, Hans Gelpke, Irene Janet Bosma, Bernd Klaeser

Technetium-99m Technegas SPECT/CT is a promising tool for the localization of postoperative air leaks in thoracic surgery patients. We report a case of successful leak detection in a mechanically ventilated patient following thoracoscopic surgery and revision. Radioventilation was performed by connecting the TechnegasPlus (Cyclomedica Pty Ltd.) generator's administration set to the patient's endotracheal tube and gently inflating the lungs with a disposable respirator through the generator's assist valve. Intense pleural Technegas accumulation was observed as a correlate of the air leak. Characteristic changes of ventilation distribution secondary to mechanical ventilation are discussed.

Technetium-99m tecnegas SPECT/CT是一种很有前途的胸外科术后漏气定位工具。我们报告一例成功的泄漏检测在机械通气患者后胸腔镜手术和修正。通过将TechnegasPlus (Cyclomedica Pty Ltd.)发生器的管理装置连接到患者的气管内管,并通过发生器的辅助阀使用一次性呼吸器轻轻地向肺部充气,进行放射通气。强烈的胸膜气体积聚被观察到与空气泄漏有关。讨论了机械通风后二次通风分布的特征变化。
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引用次数: 0
Complementary Role of [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT in Discriminating Non-Small Cell From Small Cell Lung Cancer. [68Ga]Ga-DOTA-3P-TATE-RGD PET/CT在鉴别非小细胞肺癌和小细胞肺癌中的互补作用
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1097/RLU.0000000000006258
Jialin Xiang, Yu Yan, Zhiwen Zhang, Li Zhang, Zhaohui Zhu

[ 18 F]FDG PET/CT is widely used in the diagnosis and treatment monitoring of lung cancer, yet its ability to differentiate histologic heterogeneity remains limited. In this case, a 75-year-old man presented with a large pulmonary mass adjacent to a small satellite lesion. Bronchoscopic biopsy of the main lesion revealed small-cell lung cancer (SCLC). After first-line chemotherapy, the primary lesion showed partial response, while the smaller nodule remained stable. Posttreatment [ 18 F]FDG and [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT demonstrated divergent uptake patterns. Rebiopsy of the nodule with discordant tracer uptake confirmed squamous cell carcinoma, indicating synchronous double primary lung cancers. The dual-targeted tracer PET/CT guided precise biopsy and individualized therapy.

[18F]FDG PET/CT广泛应用于肺癌的诊断和治疗监测,但其鉴别组织学异质性的能力仍然有限。在这个病例中,一位75岁的男性表现为一个大的肺肿块邻近一个小的卫星性病变。主要病变的支气管镜活检显示小细胞肺癌(SCLC)。一线化疗后,原发病灶部分缓解,小结节保持稳定。处理后[18F]FDG和[68Ga]Ga-DOTA-3P-TATE-RGD PET/CT显示不同的摄取模式。示踪剂摄取不一致的结节重新活检证实为鳞状细胞癌,提示同步双原发肺癌。双靶示踪PET/CT引导精确活检和个体化治疗。
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引用次数: 0
Novel 64 Cu-labeled Trimeric PSMA Ligand Unequivocally Identifies Local Recurrence of Prostate Cancer Ambiguously Imaged by 18 F-DCFPyL PSMA PET/CT. 新型64cu标记的三聚体PSMA配体明确识别18F-DCFPyL PSMA PET/CT模糊成像的前列腺癌局部复发。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-06-04 DOI: 10.1097/RLU.0000000000006010
Mark Bartholomä, Florian Rosar, Caroline Burgard, Stephan Maus, Moritz-Valentin Schreck, Samer Ezziddin

A 72-year-old man underwent 18 F-DCFPyL PSMA PET/CT imaging for the localization of biochemical recurrence (BCR) of prostate cancer. The scan revealed no definite findings, with only a vague uptake of uncertain significance in the bladder neck region. An additional PET/CT scan using a 64 Cu-labeled trimeric PSMA ligand demonstrated astonishing distinct uptake in the former prostate bed, unequivocally confirming the presence of a small local recurrence and allowing for targeted local therapy. This intriguing case highlights the potential of PET/CT using 64 Cu-labeled trimeric PSMA ligands, especially when conventional PSMA PET/CT scans yield ambiguous results.

1例72岁男性患者行18F-DCFPyL PSMA PET/CT显像定位前列腺癌生化复发(BCR)。扫描显示没有明确的发现,仅在膀胱颈部区域有不确定意义的模糊摄取。使用64cu标记的三聚体PSMA配体进行的额外PET/CT扫描显示,在前前列腺床中有惊人的明显摄取,明确确认存在小的局部复发,并允许靶向局部治疗。这个有趣的案例强调了使用64cu标记的三聚体PSMA配体的PET/CT的潜力,特别是当传统的PSMA PET/CT扫描结果不明确时。
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引用次数: 0
99m Tc-FAPI-46 Scintigraphy and Radioligand Therapy With 177 Lu-FAPI-2286 in Locally Advanced Epithelioid Sarcoma. 177Lu-FAPI-2286在局部晚期上皮样肉瘤中的显像和放射配位治疗。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-06-30 DOI: 10.1097/RLU.0000000000005979
Nasrin Raeisi, Amin Saber Tanha, Kamran Aryana, Soodabeh Shahid Sales, Somaye Barashki

Epithelioid sarcoma (ES) is an ultra-rare and aggressive soft tissue malignancy, predominantly affecting the extremities. Scalp involvement in ES is exceedingly uncommon. This case report describes a 25-year-old man diagnosed with a scalp mass confirmed to be ES. Despite undergoing surgical resection and adjuvant chemoradiation, the tumor recurred, causing significant pain and erosion of adjacent bony structures. A multidisciplinary team recommended 99m Tc-FAPI-46 scintigraphy, which demonstrated high uptake in the tumor masses. The patient was subsequently treated with 177 Lu-FAPI-2286 in 4 cycles. Initial cycles showed promising treatment responses; however, disease progression was observed in the final cycle.

上皮样肉瘤(ES)是一种极其罕见的侵袭性软组织恶性肿瘤,主要影响四肢。头皮受累是非常罕见的。本病例报告描述了一名25岁的男性,被诊断为头皮肿块,证实为ES。尽管接受了手术切除和辅助放化疗,但肿瘤复发,引起明显的疼痛和邻近骨结构的侵蚀。一个多学科团队推荐99mTc-FAPI-46显像,显示肿瘤肿块的高摄取。患者随后在4个周期内接受177Lu-FAPI-2286治疗。初始周期显示有希望的治疗反应;然而,在最后一个周期中观察到疾病进展。
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引用次数: 0
68 Ga-FAPI-04 PET/CT in Renal NUT Carcinoma. 68Ga-FAPI-04 PET/CT在肾癌诊断中的意义。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-10-23 DOI: 10.1097/RLU.0000000000006188
Wei Zhang, Liu Xiao, Yan Zhou, Shulei Pan, Wenjie Zhang

Primary renal NUT carcinoma is exceptionally rare. Herein, we report 68 Ga-FAPI-04 PET/CT findings in a 10-year-old girl with this malignancy. The 68 Ga-FAPI-04 PET/CT imaging revealed a right renal mass with intense FAPI uptake, accompanied by FAPI-avid retroperitoneal lymphadenopathy and pulmonary metastases. This case highlights the potential of 68 Ga-FAPI-04 PET/CT for precise staging of renal NUT carcinoma.

原发性肾NUT癌极为罕见。在此,我们报告一名10岁女孩的68Ga-FAPI-04 PET/CT表现。68Ga-FAPI-04 PET/CT成像显示右侧肾肿块伴FAPI强烈摄取,伴FAPI强烈腹膜后淋巴结病变及肺转移。本病例强调了68Ga-FAPI-04 PET/CT对肾NUT癌精确分期的潜力。
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引用次数: 0
18 F-FDG PET/CT Manifestation of Unilateral Breast Involvement in a Male Patient With T-Cell Acute Lymphoblastic Leukemia. 男性t细胞急性淋巴细胞白血病患者单侧乳腺受累的18F-FDG PET/CT表现
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1097/RLU.0000000000006272
Xilan Yao, Lijing Wei, Xiao Lei, Zheqin Wang, Jigang Yang

Unilateral breast infiltration caused by T-cell acute lymphoblastic leukemia (T-ALL) is a rare occurrence. This report presents the 18 F-FDG PET/CT findings of unilateral breast relapse in a male patient diagnosed with T-ALL. After systematic therapy, a follow-up PET/CT scan revealed no evidence of FDG-avid lesions. This case highlights the critical role of PET/CT in detecting and characterizing extramedullary disease involvement.

由t细胞急性淋巴细胞白血病(T-ALL)引起的单侧乳房浸润是一种罕见的疾病。本报告报告了一例诊断为T-ALL的男性患者单侧乳房复发的18F-FDG PET/CT表现。系统治疗后,随访PET/CT扫描未发现FDG-avid病变的证据。本病例强调了PET/CT在检测和表征髓外疾病累及方面的关键作用。
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引用次数: 0
Multimodal PET/MR Imaging in Early-onset Alzheimer's Disease With Parkinsonism due to a Novel Presenilin-1 (M233I) Mutation. 由新型早老素-1 (M233I)突变引起的早发性阿尔茨海默病伴帕金森病的多模态PET/MR成像
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1097/RLU.0000000000006238
Hanyi Fang, Anqi Tang, Cheng Tang, Xiaoli Lan, Xun Sun

We report the multimodal PET/MR imaging findings in a 31-year-old woman with a novel presenilin 1 (PSEN1) missense mutation (c.699G>A, p.M233I) who developed progressive cognitive decline and parkinsonian features. Multimodal imaging, including glucose metabolism, dopamine transporter function, amyloid-β pathology, and tau protein PET imaging, combined with structural MRI, revealed widespread abnormalities concordant with her clinical manifestations. Findings included glucose hypometabolism, dopaminergic dysfunction, amyloid and tau deposition, and cerebellar atrophy. This case highlights the diagnostic value of multiprobe PET/MR imaging in characterizing complex neurodegenerative phenotypes and expands the genotypic and phenotypic spectrum of PSEN1 -associated early-onset Alzheimer's disease (EOAD) with parkinsonism.

我们报告了一名31岁女性的多模态PET/MR成像结果,该女性患有新型早老素1 (PSEN1)错义突变(c.699G> a, p.M233I),并出现进行性认知能力下降和帕金森特征。多模式成像包括葡萄糖代谢、多巴胺转运蛋白功能、淀粉样蛋白-β病理、tau蛋白PET成像,并结合结构MRI显示广泛的异常与临床表现一致。结果包括葡萄糖代谢低下,多巴胺能功能障碍,淀粉样蛋白和tau沉积,以及小脑萎缩。本病例强调了多探针PET/MR成像在表征复杂神经退行性表型方面的诊断价值,并扩大了psen1相关早发性阿尔茨海默病(EOAD)伴帕金森病的基因型和表型谱。
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引用次数: 0
期刊
Clinical Nuclear Medicine
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